CN116326778B - Dendrobium granule and preparation method thereof - Google Patents
Dendrobium granule and preparation method thereof Download PDFInfo
- Publication number
- CN116326778B CN116326778B CN202310281383.3A CN202310281383A CN116326778B CN 116326778 B CN116326778 B CN 116326778B CN 202310281383 A CN202310281383 A CN 202310281383A CN 116326778 B CN116326778 B CN 116326778B
- Authority
- CN
- China
- Prior art keywords
- dendrobium
- granule
- powder
- donkey
- hide gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 74
- 241001523681 Dendrobium Species 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims description 63
- 108010010803 Gelatin Proteins 0.000 claims description 53
- 229920000159 gelatin Polymers 0.000 claims description 53
- 239000008273 gelatin Substances 0.000 claims description 53
- 235000019322 gelatine Nutrition 0.000 claims description 53
- 235000011852 gelatine desserts Nutrition 0.000 claims description 53
- 239000007788 liquid Substances 0.000 claims description 38
- 238000007873 sieving Methods 0.000 claims description 23
- 235000000346 sugar Nutrition 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000002386 leaching Methods 0.000 claims description 18
- 241001076416 Dendrobium tosaense Species 0.000 claims description 17
- 238000005550 wet granulation Methods 0.000 claims description 15
- 238000004537 pulping Methods 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 238000000227 grinding Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 12
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 10
- 238000005520 cutting process Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000010025 steaming Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 abstract description 12
- 150000004676 glycans Chemical class 0.000 abstract description 10
- 229920001282 polysaccharide Polymers 0.000 abstract description 10
- 239000005017 polysaccharide Substances 0.000 abstract description 10
- 239000000654 additive Substances 0.000 abstract description 7
- 239000002244 precipitate Substances 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 239000003960 organic solvent Substances 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 241000026010 Dendrobium candidum Species 0.000 description 35
- 230000000052 comparative effect Effects 0.000 description 27
- 238000000605 extraction Methods 0.000 description 21
- 239000006228 supernatant Substances 0.000 description 17
- 238000000643 oven drying Methods 0.000 description 16
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 14
- 240000004638 Dendrobium nobile Species 0.000 description 13
- 239000011435 rock Substances 0.000 description 13
- 238000002390 rotary evaporation Methods 0.000 description 12
- 238000004140 cleaning Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- 230000001476 alcoholic effect Effects 0.000 description 6
- 108010052008 colla corii asini Proteins 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 235000021551 crystal sugar Nutrition 0.000 description 6
- RYAHJFGVOCZDEI-CZKZLRAZSA-N dendrobine Natural products O=C1O[C@@H]2[C@H](C(C)C)[C@H]1[C@H]1[C@@]3(C)[C@@H]2N(C)C[C@H]3CC1 RYAHJFGVOCZDEI-CZKZLRAZSA-N 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- RYAHJFGVOCZDEI-UFFNCVEVSA-N Dendrobine Chemical compound C([C@H]1CC[C@@H]2[C@@]31C)N(C)[C@@H]3[C@H]1[C@@H](C(C)C)[C@@H]2C(=O)O1 RYAHJFGVOCZDEI-UFFNCVEVSA-N 0.000 description 3
- -1 dendrobine compound Chemical class 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- QWUWMCYKGHVNAV-UHFFFAOYSA-N 1,2-dihydrostilbene Chemical group C=1C=CC=CC=1CCC1=CC=CC=C1 QWUWMCYKGHVNAV-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 description 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 description 1
- 235000009685 Crataegus X maligna Nutrition 0.000 description 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 description 1
- 235000009486 Crataegus bullatus Nutrition 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000009682 Crataegus limnophila Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 235000002313 Crataegus paludosa Nutrition 0.000 description 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- 244000150195 Cyperus longus Species 0.000 description 1
- 235000018109 Cyperus longus Nutrition 0.000 description 1
- 244000075634 Cyperus rotundus Species 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 235000005010 Scirpus paludosus Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 230000036996 cardiovascular health Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to dendrobium medicinal granules and a preparation method thereof, and belongs to the technical field of food processing of nutritional medicinal granules. Aiming at the technical problems that the dendrobium granule has low content of active ingredients and is unfavorable for long-term eating due to poor solubility of the dendrobium granule, or excessive auxiliary materials are added, or excessive additives are added, or the dendrobium granule is extracted by an organic solvent for many times in a process in the prior art, the dendrobium granule is not beneficial to long-term eating, and the organic solvent is remained. The dendrobium polysaccharide in the dendrobium medicinal granules prepared by the method has high effective content, can be drunk for a long time, has good solubility, improves the brewing property, and has no obvious precipitate.
Description
Technical Field
The invention belongs to the technical field of processing of nutritional granule foods, and particularly relates to a dendrobium granule and a preparation method thereof.
Background
Dendrobium officinale (Dendrobium officinale Kimura et Migo) is a rare Chinese herbal medicine in China, is a plant of Dendrobium in Orchidaceae, is named because the epidermis is iron green, and has the effects of promoting fluid production, nourishing yin, improving eyesight, nourishing stomach, tonifying kidney, strengthening body and the like. The main medicinal components in dendrobium plants are polysaccharide, alkaloid, glycoside, phenanthrene, bibenzyl, amino acid and the like reported in literature. The polysaccharide has high content in Dendrobium officinale, and has good effects of regulating blood sugar, resisting tumor, resisting oxidation, enhancing immunity, etc. The dendrobium candidum has high polysaccharide content and high viscosity, and is poor in solubility when being prepared into medicinal granules. Therefore, in order to improve the solubility of the granule and reduce the cost, the traditional dendrobium candidum granule on the market is mainly compound granule, and the dendrobium candidum content is low, for example, the publication number of Chinese patent application is CN108741055A, and the application date is 31 days of 2018 and 05 months, and the name is: a composite granule for coordinating intestines and stomach is disclosed, which comprises the following raw materials: dendrobium officinale, cinnamon, chinese yam, hawthorn, lotus seeds, dangshen, spina date seeds, green tea powder, nutgrass galingale rhizome, chrysanthemum, borneol, pseudo-ginseng, coix seeds and auxiliary materials.
In addition to the mode of compounding various edible and medicinal homologous plants, in the prior art, an additive mode is adopted in order to solve the problem that dendrobe is not easy to dissolve. For example, chinese patent application publication No. CN108478608A, application date 2018, month 05, 21, and name: a nanometer dendrobine health granule. The disclosed raw materials comprise: nano dendrobine compound particles, auxiliary materials, a disintegrating agent and a lubricant. The nanometer dendrobine compound granule is prepared by adopting the following process: adding dendrobine, arecoline, anoectoine and chitosan into an aqueous solution of acetic acid, uniformly mixing, and carrying out heat preservation and standing to obtain a prefabricated material A; dissolving sodium tripolyphosphate and polysorbate in water, adding into the prefabricated material, and stirring to obtain a prefabricated material B; and (3) carrying out vacuum freeze-drying on the prefabricated material B to obtain the nano dendrobine compound particles. The nanometer dendrobine health-care granule has high re-dissolution speed, but is added with various additives such as disintegrating agent, lubricant and the like. Herba Dendrobii granule is served as a health food granule for the elderly, and the elderly is especially three-high key people, and excessive additives can cause cardiovascular health problem.
In order to reduce excessive compound raw materials and reduce the use of additives or not, the prior art has been explored in technology, such as chinese patent application publication No. CN113142582a, application date 2021, month 03 and 10, and named: an instant dendrobium candidum powder and a preparation method thereof, wherein the disclosed method comprises the following steps: firstly peeling cleaned fresh dendrobium candidum strips, adding a color fixative and water, pulping by adopting an anaerobic wet superfine grinding mode, transferring the slurry to an anaerobic condition for low-temperature ultrasonic auxiliary extraction, centrifuging at low temperature to obtain a supernatant A and a precipitate A, adding the precipitate A into a 90-100% ethanol aqueous solution for low-temperature ultrasonic auxiliary extraction again, centrifuging at low temperature to obtain a supernatant B and a precipitate B, merging the supernatant A and the supernatant B, concentrating the supernatant, freeze-drying, and preparing the dendrobium candidum instant powder by adopting the superfine grinding mode. However, the method has the advantages that the nutrient elements of the dendrobium are destroyed by repeated soaking in the organic solvent in the preparation process, and the dendrobium can be remained in the subsequent processing process, so that the dendrobium is not beneficial to the health of the body due to repeated drinking.
Disclosure of Invention
1. Problems to be solved
Aiming at the technical problems that the dendrobium medicinal granules are low in active ingredient content and unfavorable for long-term eating due to poor solubility of the dendrobium medicinal granules, excessive auxiliary materials are added, excessive additives are added, or the dendrobium medicinal granules are extracted by an organic solvent for many times in a process in the prior art, the dendrobium medicinal granules have high active ingredient content, can be drunk for a long time, are good in solubility, and have no obvious precipitate when the brewing property is improved.
2. Technical proposal
In order to achieve the above purpose, the technical scheme provided is as follows:
the preparation method of the dendrobium medicinal granules comprises the following components in parts by weight: 80-170 parts of donkey-hide gelatin powder, 10-90 parts of dendrobium extract, 5-65 parts of ice sugar powder and 8-45 parts of yellow wine with the alcohol content of 10-20%;
the dendrobium medicinal granules are prepared by wet granulation.
Besides seasoning, the rock candy can play a good role in assisting dissolution, and the adding amount of the dendrobium extract can be increased by adding the rock candy.
Further, the method comprises the following steps:
comprises the steps of preparing dendrobium extract to obtain dendrobium extract;
comprises the steps of superfine grinding donkey-hide gelatin and rock candy, and sieving to obtain donkey-hide gelatin powder and rock candy powder;
comprises the step of adding yellow wine with the alcohol content of 10-20% into the dendrobium extract, donkey-hide gelatin powder and rock candy powder, and carrying out wet granulation to obtain the dendrobium medicinal granules.
Preferably, the method further comprises the steps of drying and sieving after wet granulation: drying at 40 ℃; sieving with 40 mesh sieve.
The donkey-hide gelatin is compounded and is added with yellow wine for granulation, so that the problem of poor solubility of the dendrobium medicinal granules is well solved.
Further, the preparation of the dendrobium extract comprises the following steps: pulping fresh dendrobium, adding water, filtering, and steaming until the feed-liquid ratio is 1:4.5-5.5.
In the range of the feed-liquid ratio, the viscosity of the dendrobium polysaccharide is in the subsequent treatment, and the prepared medicinal granules have optimal solubility.
Preferably, 200 mesh gauze is used for filtration.
Further, after the water adding step, the initial feed-liquid ratio is 1:25-35.
Preferably, the initial feed-to-liquid ratio is 1:30.
The ratio of the initial feed liquid is too high, the longer the processing time is, the higher the energy consumption is, the longer the extraction time is, the dendrobium polysaccharide and the like are easy to produce side reaction, the solubility is reduced, the nutrition components are lost, and harmful substances are produced. The initial feed-liquid ratio is too low to extract the active ingredients such as dendrobium polysaccharide.
Further, the leaching temperature is 75-85 ℃ and the time is 2.5-3.5 h.
Preferably, the leaching temperature is 80 ℃ and the time is 3 hours.
The extraction temperature is too low, the longer the processing time is, the higher the energy consumption is, the longer the extraction time is, and the effective components such as dendrobium polysaccharide cannot be extracted. The leaching temperature is too high, which is easy to cause side reaction of dendrobium polysaccharide and the like, and reduces the solubility, and simultaneously, the nutrient components are lost to generate harmful substances.
Further, the mesh number of the donkey-hide gelatin powder and the ice sugar powder is 100 mesh.
The donkey-hide gelatin powder and the ice sugar powder have excessively high mesh number, are too fine, increase viscosity and have poor solubility. The donkey-hide gelatin powder and the ice sugar powder have low mesh number, large particles and increased granule precipitation when the donkey-hide gelatin powder and the ice sugar powder cannot be well granulated.
Further, the dendrobium is dendrobium candidum.
Further, the technological parameters of the wet granulation are as follows:
mixing materials: stirring knife 200r/min, cutting knife 300r/min, and time 3min;
adding a material liquid: stirring knife 160r/min, cutting knife 300r/min, and time 3min;
granulating: stirring knife 400r/min, cutting knife 2400r/min, time 2min.
A herba Dendrobii granule is prepared by the preparation method.
Further, the composition comprises the following components in percentage by weight: 112 parts of donkey-hide gelatin powder, 56 parts of dendrobium extract, 48 parts of rock candy powder and 12 parts of yellow wine with the alcohol content of 15 percent.
3. Advantageous effects
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
(1) The invention relates to a preparation method of dendrobium medicinal granules, which is prepared from raw materials including donkey-hide gelatin powder, sugar powder, dendrobium extract and yellow wine by wet granulation. Donkey-hide gelatin is introduced into the raw materials, and yellow wine is adopted for granulation, so that the solubility of the dendrobium medicinal granules is improved. The obtained herba Dendrobii granule contains no other adjuvants, has high effective content of herba Dendrobii polysaccharide, no additive, and can be drunk for a long time, with good solubility and improved brewing property, without obvious precipitation.
(2) The dendrobium medicinal granules are prepared by the method. The donkey-hide gelatin is added, the main component is collagen, the dissolution assisting effect is achieved, the fishy smell of the donkey-hide gelatin can be well covered by dendrobium nobile, and the granule flavor is improved. The granule is light brown powder, slightly sweet, has lighter donkey-hide gelatin smell, has stronger donkey-hide gelatin fragrance, has lighter dendrobium candidum smell, is immediately soluble in water, and has yellow brown color and obvious dendrobium candidum flavor after being brewed, and the solution is uniform.
Drawings
Fig. 1 is a photograph of dendrobe granule prepared in example 1.
Detailed Description
For a further understanding of the present invention, the present invention will be described in detail with reference to examples.
Example 1
(1) The dendrobium candidum used in the embodiment is pulped after being cleaned, hot water extraction (the liquid-to-liquid ratio is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifugation (5000 rpm,10 min) is carried out to obtain supernatant, and rotary evaporation and concentration are carried out by using a rotary evaporator until the liquid-to-liquid ratio is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder: dendrobium officinale extract, rock sugar and yellow wine (alcohol content is 15%) =28:14:12:3 (mass ratio).
(4) Heating colla Corii Asini powder, herba Dendrobii extract and crystal sugar powder (120deg.C), mixing, oven drying (55deg.C), micronizing, sieving with 100 mesh sieve, and oven drying (55deg.C).
Wet granulation, the process parameters are as follows:
mixing materials: stirring knife 200r/min, cutting knife 300r/min, and time 3min;
adding a material liquid: stirring knife 160r/min, cutting knife 300r/min, and time 3min;
granulating: stirring knife 400r/min, cutting knife 2400r/min, time 2min.
Yellow wine (15%) was added as binder.
Oven-drying (55deg.C), and sieving with 40 mesh sieve to obtain sample.
The dendrobium nobile granule prepared by the embodiment is light brown powder, slightly sweet, lighter in donkey-hide gelatin smell, stronger in donkey-hide gelatin smell, lighter in dendrobium candidum smell, instant in water, yellow-brown after brewing, obvious in dendrobium candidum flavor, uniform in solution and free of obvious precipitation.
Example 2
(1) Cleaning Dendrobium officinale, pulping, leaching with hot water (the material-liquid ratio is 1:25, the leaching temperature is 75 ℃, the leaching time is 3.5 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the material-liquid ratio is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder, dendrobium candidum extract, rock sugar and yellow wine (the alcoholic strength is 15%) =36:6:12:3 (mass ratio).
(4) Heating colla Corii Asini powder, herba Dendrobii extract and crystal sugar (120deg.C), mixing, oven drying (55deg.C), micronizing, sieving with 100 mesh sieve, and oven drying (55deg.C).
(5) Wet granulation, the process parameters were the same as in example 1, with yellow wine (15% alcoholicity) added as binder.
Oven-drying (55deg.C), and sieving with 40 mesh sieve to obtain sample.
The dendrobium nobile granule prepared by the embodiment is light brown powder, slightly sweet, lighter in donkey-hide gelatin smell, stronger in donkey-hide gelatin smell, unobvious in dendrobium candidum smell, instant in water, yellowish-brown after brewing, unobvious in dendrobium candidum flavor, uniform in solution and free of obvious sediment.
Example 3
(1) Cleaning Dendrobium officinale, pulping, leaching with hot water (the material-liquid ratio is 1:35, the leaching temperature is 85 ℃, the leaching time is 2.5 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the material-liquid ratio is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder, dendrobium candidum extract, rock sugar and yellow wine (the alcoholic strength is 15%) =20:22:12:3 (mass ratio).
(4) Heating colla Corii Asini powder, herba Dendrobii extract and crystal sugar (120deg.C), mixing, oven drying (55deg.C), micronizing, sieving with 100 mesh sieve, and oven drying (55deg.C).
(5) Wet granulation, the process parameters were the same as in example 1, with yellow wine (15% alcoholicity) added as binder.
(6) Oven-drying (55deg.C), and sieving with 40 mesh sieve to obtain sample.
The dendrobium nobile granule prepared by the embodiment is light brown powder, slightly sweet, lighter in donkey-hide gelatin fishy smell, stronger in donkey-hide gelatin fragrance, and general in solubility, and has yellowish-brown color after brewing, obvious dendrobium nobile flavor, uniform in solution and no obvious precipitate.
Comparative example 1
The dendrobium granule of the comparative example is basically the same as that of the example 1, except that the raw materials only comprise dendrobium and donkey-hide gelatin, and the process uses pulverization instead of wet granulation, and the method specifically comprises the following steps:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder, and dendrobium candidum extract=2:1 (mass ratio).
(4) Fully and uniformly mixing donkey-hide gelatin powder and dendrobium candidum extract, drying (55 ℃), ultrafine grinding, sieving with a 80-mesh sieve, and drying (55 ℃) again.
The dendrobium nobile granule prepared by the comparative example is yellow-brown powder, has large fishy smell of donkey-hide gelatin, lighter smell of dendrobium candidum, is difficult to dissolve, has yellow-brown color after brewing, has lighter flavor of dendrobium candidum, is uniform in solution and has a small amount of sediment.
Comparative example 2
The dendrobium granule of the comparative example is basically the same as that of example 1, except that the wet granulation is replaced by crushing in the process, and the method specifically comprises the following steps:
(1) Cleaning Dendrobium officinale, pulping, leaching with hot water (the material-liquid ratio is 1:20, the leaching temperature is 80 ℃, the leaching time is 4 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the material-liquid ratio is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder, dendrobium candidum extract, rock sugar and yellow wine (the alcoholic strength is 15%) =28:14:12:3 (mass ratio).
(4) Fully and uniformly mixing donkey-hide gelatin powder and dendrobium candidum extract, drying (55 ℃), ultrafine grinding, sieving with a 80-mesh sieve, and drying (55 ℃) again.
The dendrobium nobile granule prepared by the comparative example is yellow-brown powder, has large fishy smell of donkey-hide gelatin, lighter smell of dendrobium candidum, is easy to dissolve, takes yellow-brown color after brewing, has lighter flavor of dendrobium candidum, is uniform in solution and has a small amount of sediment.
Comparative example 3
The dendrobium granule of the comparative example is basically the same as that of example 1, except that the wet granulation is replaced by crushing in the process, and the method specifically comprises the following steps:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:5.
(2) The formula is dendrobium candidum extract liquid, wherein maltodextrin=25:1.
(3) The powder is prepared by a spray dryer, the air inlet temperature is 150 ℃, the air outlet temperature is 80-90 ℃, the air flow rate is 90% and the pump speed is 20%.
The dendrobium nobile granule prepared in the comparative example is yellow green, has a strong dendrobium candidum flavor and is difficult to dissolve.
Comparative example 4
The dendrobium medicinal granules of the comparative example are basically the same as the embodiment 1, except that common alcohol is used for replacing yellow wine in the process for granulating, and the dendrobium medicinal granules are specifically as follows:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula comprises donkey-hide gelatin powder, dendrobium candidum extract and rock sugar, wherein the mass fraction of the donkey-hide gelatin powder is 15% alcohol=28:14:12:3 (mass ratio).
(4) Heating colla Corii Asini powder, herba Dendrobii extract and crystal sugar (120deg.C), mixing, oven drying (55deg.C), micronizing, sieving with 100 mesh sieve, and oven drying (55deg.C).
(5) Wet granulation, the parameters are the same as above, and 15% alcohol is added as adhesive.
(6) Oven-drying (55deg.C), and sieving with 40 mesh sieve to obtain sample.
The dendrobium nobile granule prepared by the comparative example is light brown powder, has larger partial particles, is slightly sweet, has lighter donkey-hide gelatin fishy smell, has the donkey-hide gelatin flavor but has larger alcohol smell, has lighter dendrobium candidum flavor, is difficult to dissolve, is yellow brown after being brewed, has the dendrobium candidum flavor, and has uniform solution and no obvious precipitation.
Comparative example 5
The dendrobium nobile granule of the comparative example is basically the same as that of the example 1, except that the alcoholic strength of the yellow wine is different, and the following is concrete:
(1) Cleaning Dendrobium officinale, pulping, leaching with hot water (the material-liquid ratio is 1:30, the leaching temperature is 80 ℃, leaching is carried out for 3 hours), centrifuging (5000 rpm,10 minutes) to obtain supernatant, and carrying out rotary evaporation and concentration by using a rotary evaporator until the material-liquid ratio is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder, dendrobium candidum extract, rock sugar and yellow wine (the alcoholic strength is 8%) =28:14:12:3 (mass ratio).
(4) Heating colla Corii Asini powder, herba Dendrobii extract and crystal sugar (120deg.C), mixing, oven drying (55deg.C), micronizing, sieving with 100 mesh sieve, and oven drying (55deg.C).
(5) Wet granulation, the process parameters were the same as in example 1, with yellow wine (8% alcoholicity) added as binder.
(6) Oven-drying (55deg.C), and sieving with 40 mesh sieve to obtain sample.
The dendrobium nobile granule prepared by the comparative example is light brown powder, slightly large in particle size, slightly sweet, slightly Xu Ajiao fishy, has donkey-hide gelatin fragrance, is lighter in dendrobium candidum flavor, is soluble in water, is yellowish brown after brewing, is obvious in dendrobium candidum flavor, is uniform in solution and has no obvious precipitation.
Comparative example 6
The dendrobium medicinal granules of the comparative example are basically the same as the embodiment 1, except that the raw materials have different composition ratios, and the dendrobium medicinal granules are specifically as follows:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:5.
(2) The donkey-hide gelatin blocks are crushed in an ultrafine way and then are sieved by a 100-mesh sieve. And (5) ultrafine grinding the rock sugar and sieving with a 100-mesh sieve.
(3) The formula is donkey-hide gelatin powder, dendrobium candidum extract, ice sugar powder and yellow wine (the alcoholic strength is 15%) =7:35:12:3 (mass ratio).
(4) Heating colla Corii Asini powder, herba Dendrobii extract and crystal sugar powder (120deg.C), mixing, oven drying (55deg.C), and pulverizing to obtain sample with high humidity and viscosity.
The granule prepared in this comparative example could not be dried, and the final product could not be obtained.
Comparative example 7
The dendrobium medicinal granules of the comparative example are basically the same as the embodiment 1, except that the production process is as follows:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:5.
(2) The powder is prepared by a spray dryer, the air inlet temperature is 150 ℃, the air outlet temperature is 80-90 ℃, the air flow rate is 90% and the pump speed is 20%.
The granule prepared in this comparative example could not be obtained in the collector, and was mostly stuck in the wall of the spray dryer.
Comparative example 8
The dendrobium medicinal granules of the comparative example are basically the same as the embodiment 1, except that the production process is as follows:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:3.
The powder is prepared by a spray dryer, the air inlet temperature is 150 ℃, the air outlet temperature is 80-90 ℃, the air flow rate is 90% and the pump speed is 20%.
The granule prepared in this comparative example could not be obtained in the collector, and most of the granule was adhered to the wall of the spray dryer, and the viscosity of the feed liquid was high, so that the nozzle was easily blocked.
Comparative example 9
The dendrobium nobile granule of the comparative example is basically the same as that of the example 1, except that maltitol is adopted as an auxiliary material, and the dendrobium nobile granule is specifically as follows:
(1) Cleaning Dendrobium officinale, pulping, extracting with hot water (the ratio of feed to liquid is 1:30, the extraction temperature is 80 ℃, the extraction time is 3 h), centrifuging (5000 rpm,10 min) to obtain supernatant, and performing rotary evaporation and concentration by using a rotary evaporator until the ratio of feed to liquid is 1:5.
(2) The formula is dendrobium candidum extract liquid, wherein maltitol=25:1.
(3) The powder is prepared by a spray dryer, the air inlet temperature is 150 ℃, the air outlet temperature is 80-90 ℃, the air flow rate is 90% and the pump speed is 20%.
The granule prepared in the comparative example is yellow green, has intense dendrobium candidum flavor, is soluble in water, and requires longer time.
The foregoing examples have shown only the preferred embodiments of the invention, which are described in more detail and are not to be construed as limiting the scope of the invention. It should be noted that modifications, improvements and substitutions can be made by those skilled in the art without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (8)
1. A preparation method of dendrobium medicinal granules is characterized by comprising the following steps of: the composition comprises the following components in percentage by weight: 80-170 parts of donkey-hide gelatin powder, 10-90 parts of dendrobium extract, 5-65 parts of rock candy powder and 8-45 parts of yellow wine with the alcohol content of 10-20%; the dendrobium medicinal granules are prepared by wet granulation; the method comprises the following steps:
comprises the steps of preparing dendrobium extract to obtain dendrobium extract;
comprises the steps of superfine grinding donkey-hide gelatin and rock candy, and sieving to obtain donkey-hide gelatin powder and rock candy powder;
adding yellow wine with the alcohol content of 10-20% into the dendrobium extract, donkey-hide gelatin powder and rock candy powder, and granulating by a wet method to obtain dendrobium medicinal granules;
the preparation method of the dendrobium extract comprises the following steps: pulping fresh dendrobium, adding water, leaching, filtering, and steaming until the feed-liquid ratio is 1:4.5-5.5.
2. The method for preparing dendrobium granule according to claim 1, wherein: after the water adding step, the initial feed-liquid ratio is 1:25-35.
3. The method for preparing dendrobium granule according to claim 1, wherein: the leaching temperature is 75-85 ℃ and the leaching time is 2.5-3.5 h.
4. The method for preparing dendrobium granule according to claim 1, wherein: the mesh number of the donkey-hide gelatin powder and the ice sugar powder is 100 meshes.
5. The method for preparing dendrobium granule according to any one of claims 1 to 4, wherein: the herba Dendrobii is Dendrobium officinale.
6. The method for preparing dendrobium granule according to claim 5, wherein: the technological parameters of the wet granulation are as follows:
mixing materials: stirring knife 200r/min, cutting knife 300r/min, and time 3min;
adding a material liquid: stirring knife 160r/min, cutting knife 300r/min, and time 3min;
granulating: stirring knife 400r/min, cutting knife 2400r/min, time 2min.
7. A dendrobium granule is characterized in that: is prepared by the preparation method according to any one of claims 1 to 6.
8. The dendrobium granule of claim 7, wherein: the composition comprises the following components in percentage by weight: 112 parts of donkey-hide gelatin powder, 56 parts of dendrobium extract, 48 parts of rock candy powder and 12 parts of yellow wine with the alcohol content of 15 percent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310281383.3A CN116326778B (en) | 2023-03-20 | 2023-03-20 | Dendrobium granule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310281383.3A CN116326778B (en) | 2023-03-20 | 2023-03-20 | Dendrobium granule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116326778A CN116326778A (en) | 2023-06-27 |
| CN116326778B true CN116326778B (en) | 2024-03-08 |
Family
ID=86875724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310281383.3A Active CN116326778B (en) | 2023-03-20 | 2023-03-20 | Dendrobium granule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116326778B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526106A (en) * | 2010-12-31 | 2012-07-04 | 山东东阿阿胶股份有限公司 | Donkey-hide gelatine raw powder and preparation method thereof |
| CN103751561A (en) * | 2014-02-18 | 2014-04-30 | 云南众爱生物科技有限公司 | Dendrobium officinale pure powder tablet and preparation method thereof |
| CN107019761A (en) * | 2016-01-29 | 2017-08-08 | 林东昊 | A kind of instant stem of noble dendrobium fine grained and preparation method thereof |
| CN108112991A (en) * | 2018-02-06 | 2018-06-05 | 张艳飞 | A kind of health food and preparation method and application |
| CN108452199A (en) * | 2018-04-27 | 2018-08-28 | 安徽皖斛堂生物科技有限公司 | One kind refreshes the mind the compound electuary of the stem of noble dendrobium |
| CN109497203A (en) * | 2018-11-30 | 2019-03-22 | 黄绪明 | A kind of preparation method of donkey-hide gelatin dark green tea |
| CN112587551A (en) * | 2020-12-16 | 2021-04-02 | 北京同仁堂（唐山）营养保健品有限公司 | Donkey-hide gelatin brewing decoction pieces and preparation process thereof |
| CN115644437A (en) * | 2022-10-28 | 2023-01-31 | 东阿阿胶保健品有限公司 | Portable donkey-hide gelatin-containing fruit and vegetable instant composite particle and preparation method thereof |
-
2023
- 2023-03-20 CN CN202310281383.3A patent/CN116326778B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526106A (en) * | 2010-12-31 | 2012-07-04 | 山东东阿阿胶股份有限公司 | Donkey-hide gelatine raw powder and preparation method thereof |
| CN103751561A (en) * | 2014-02-18 | 2014-04-30 | 云南众爱生物科技有限公司 | Dendrobium officinale pure powder tablet and preparation method thereof |
| CN107019761A (en) * | 2016-01-29 | 2017-08-08 | 林东昊 | A kind of instant stem of noble dendrobium fine grained and preparation method thereof |
| CN108112991A (en) * | 2018-02-06 | 2018-06-05 | 张艳飞 | A kind of health food and preparation method and application |
| CN108452199A (en) * | 2018-04-27 | 2018-08-28 | 安徽皖斛堂生物科技有限公司 | One kind refreshes the mind the compound electuary of the stem of noble dendrobium |
| CN109497203A (en) * | 2018-11-30 | 2019-03-22 | 黄绪明 | A kind of preparation method of donkey-hide gelatin dark green tea |
| CN112587551A (en) * | 2020-12-16 | 2021-04-02 | 北京同仁堂（唐山）营养保健品有限公司 | Donkey-hide gelatin brewing decoction pieces and preparation process thereof |
| CN115644437A (en) * | 2022-10-28 | 2023-01-31 | 东阿阿胶保健品有限公司 | Portable donkey-hide gelatin-containing fruit and vegetable instant composite particle and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116326778A (en) | 2023-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103493930B (en) | A kind of momordica grosvenori ginger tea and preparation method thereof | |
| CN104623312B (en) | A kind of stem of noble dendrobium instant powder, preparation method and the usage | |
| CN103734741B (en) | A kind of preparation method and application of wolfberry fruit extract | |
| CN104232385A (en) | Preparation method for lotus leaf health-care beer | |
| KR102332053B1 (en) | Method for producing functional salt | |
| CN101829209B (en) | Preparation method of fruit-flavored sweet tea polyphenols | |
| KR101140156B1 (en) | Method for manufacturing functional salt using mulberry leaves | |
| CN102423049B (en) | Instant fern powder and production method thereof | |
| KR101051519B1 (en) | Method for manufacturing ginseng-berry extract | |
| CN107319054A (en) | A kind of lotus leaf black tea and preparation method thereof | |
| CN105961983A (en) | Solid beverage and preparation method thereof | |
| CN101861988B (en) | Preparation method of fruity Rubus suavissimus flavone lozenge | |
| CN106832021A (en) | A kind of preparation method of Chinese cassia tree slag Thick many candies | |
| CN116326778B (en) | Dendrobium granule and preparation method thereof | |
| CN112851722B (en) | Preparation method of geniposide and gardenia yellow pigment | |
| CN104725218A (en) | Method for extracting and purifying hydroxycitric acid from garcinia cambogia | |
| CN105876209A (en) | Pigfeed additive for promoting digestive juice secretion | |
| CN1268231C (en) | Preparation method of instant powdered coriander microcapsule flavouring | |
| CN112717009B (en) | Preparation method of gardenia extract | |
| CN104783133A (en) | Health-care sauce with bamboo fragrance and preparation method of sauce | |
| CN108719718A (en) | A kind of solid beverage and preparation method thereof improving functions of intestines and stomach | |
| CN111280365A (en) | Garlic polysaccharide microcapsule and preparation method and application thereof | |
| CN101095538A (en) | Waxberry beverage particles and preparing process thereof | |
| CN103598583A (en) | Mallotus oblongifolius buccal tablets and preparation method thereof | |
| CN108157914A (en) | Plant salt with digestion-aid effect and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |