CN101861988B - Preparation method of fruity Rubus suavissimus flavone lozenge - Google Patents

Preparation method of fruity Rubus suavissimus flavone lozenge Download PDF

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CN101861988B
CN101861988B CN2010101584986A CN201010158498A CN101861988B CN 101861988 B CN101861988 B CN 101861988B CN 2010101584986 A CN2010101584986 A CN 2010101584986A CN 201010158498 A CN201010158498 A CN 201010158498A CN 101861988 B CN101861988 B CN 101861988B
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sweet tea
powder
dry
extract
mesh sieves
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CN101861988A (en
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杨洋
程雅芳
温富雄
韦银凤
袁经权
缪剑华
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Guangxi Botanical Garden of Medicinal Plants
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Guangxi Botanical Garden of Medicinal Plants
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Abstract

The invention relates to a preparation method of a Rubus suavissimus flavone lozenge. The method comprises the following steps: adding auxiliary materials, preparing soft material, pelletizing, drying, straightening granule, adding lubricant, mixing with essence and tabletting. The method is to dry Rubus suavissimus flavone extract at 60-70 DEG C, grind the extract, sieve the obtained product with a 60-100 meshes of sieve and prepare the Rubus suavissimus flavone extract powder. By using the method, a great deal of rubusoside can be maintained and used as the natural sweetener, and the Rubus suavissimus flavone extract can be used to prepare the lozenge which is convenient to take.

Description

The preparation method of fruity Rubus suavissimus flavone lozenge
Technical field
The present invention relates to a kind of preparation method of fruity Rubus suavissimus flavone lozenge, particularly adopt the dual-purpose famous and precious plant resources of Guangxi natural medicine-food, with biological and chemical, organically combine extracting method.
Background technology
The sweet tea of the rose family (formal name used at school Rubus Suavissimus S.Lee, English name Sweet tea), have another name called the sweetleaf raspberry, for outstanding ditch belongs to perennial wait-a-bit.This sweet tea main product in Liuzhou, the area such as Guilin, Wuzhou, because its leaf is hidden sweet, with health role, Guangxi Chang Yiye among the people is when tea-drinking use, therefore named sweet tea, also claim refreshing tea, is Guangxi distinctive nontoxic, low calorie, high sugariness and the wild rare sweet taste plant with health care.Flavones wherein, medical circle research confirmation, flavones is the good merchantable brand of control cardiovascular and cerebrovascular disease and cancer-resisting.Sweet theine is the diterpene glycosides that steviol and glucose are combined into.The sugariness of sweet theine is 300 times of sucrose, is a kind of low-calorie non-sugar sweetener.
Think that at present sweet tea has distinguishing feature: (1) sweet tea nature and flavor are sweet, flat, nontoxic, in Guangxi among the people with leaf when tea-drinking with long, be used as medicine clearing heat and detoxicating, moistening lung is arranged, the effect of expelling phlegm and arresting coughing; Normal drink has the effect of nourishing liver and kidney, relieve sore throat, can prevent and treat the diseases such as heat is coughed, sphagitis, hoarseness; (2) Japan medical science circle is found, sweet tea, except above-mentioned medicinal function, also has anti-inflammatory, antianaphylaxis effect, can effectively improve pollen hypersensitivity, abscess of throat, rhinitis patient's symptom all the year round.(3) people favor three kinds of most valuable compositions that contain in sweet tea most: flavones, polyphenol and sweetener.Flavones has control cardiovascular and cerebrovascular disease, senile peripheral circulation disfunction etc.; Tea Polyphenols can suppress atherosclerotic formation, prevents and treats coronary heart disease; (4) sweet theine can be dissolved in tea with various active ingredient naturally, makes tea have a sugar-free naturally sweet, the good to eat unique function of health care again.The auxiliary curing that can be used for the diseases such as diabetes, hypertension.(5) to hyperhydrochloria person, have stomach invigorating dispel stagnant, the appetizing digestion-aid effect; (6) after the person of drinking beyond one's capacity drinks, can refresh oneself and sober up: (7) also have numerous health cares such as improving body immunity, cancer-resisting, anti-ageing, beauty treatment simultaneously.All-ages, be low heat value, sweet taste, the Trinitarian functional health tea of drug effect.
Summary of the invention
The preparation method who the purpose of this invention is to provide a kind of fruity Rubus suavissimus flavone lozenge, the method can retain a large amount of sweet theine as natural sweetener, and sweet tea extractive of general flavone is made to lozenge, instant edible.
The present invention is achieved in that
A kind of preparation method of fruity Rubus suavissimus flavone lozenge, comprise and add auxiliary material, and softwood processed is granulated, drying, whole grain, add lubricant and essence and mix and the compressing tablet step, the method be by sweet tea chromocor extract 60~70 ℃ of oven dry, cross the 60-100 mesh sieve after pulverizing, obtain sweet tea chromocor extract powder.
Described sweet tea chromocor extract is made by the following method:
First 40 purpose sweet tea powders are adopted 70% ethanol percolation to extract, or use the alcohol extracting circumfluence method, or ultrasonic extraction, or microbial enzyme extraction method and, after the medicinal extract that obtains, 60 ℃ of oven dry, obtain containing the sweet tea chromocor extract powder of flavones 6.33~11.1%.
Described sweet tea chromocor extract is extracted and is made as follows by ethanol percolation:
Pulverize dry sweet tea, cross 40 mesh sieves, add 70% alcohol immersion 2 hours of 1 times of amount of dry powder quality, then add 70% ethanol percolation of 10 times of dry powder quality to extract, the speed of diafiltration is 3 ml/min.The Vacuum Concentration percolate, air drying obtains sweet tea chromocor extract powder.
Described sweet tea chromocor extract is made as follows by the alcohol extracting circumfluence method:
Pulverize dry sweet tea and cross 40 mesh sieves, add 65% ethanol of 25 times of dry powder quality under the condition of 70 ℃, refluxing extraction 80 minutes, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim supernatant, residue uses 65% ethanol of equal in quality again under the condition of 70 ℃, refluxing extraction 80 minutes, repeat above operation, merge extract.The Vacuum Concentration extract, air drying obtains sweet tea chromocor extract powder.
Described sweet tea chromocor extract extracts and makes as follows with ultrasonic extraction:
Pulverize dry sweet tea and cross 40 mesh sieves, add 60% ethanol of 35 times of dry powder quality at room temperature to soak 2 hours, extract 30 minutes in ultrasonoscope 40 ℃ of waters of power with 60% under the 130W condition, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim supernatant, residue uses 60% ethanol of equal in quality again under the condition of 40 ℃, ultrasonic extraction 80 minutes, repeat above operation, merge extract.The Vacuum Concentration extract, air drying obtains sweet tea chromocor extract powder.
Described sweet tea chromocor extract is made as follows by the microbial enzyme extraction method:
Pulverize sweet tea and cross 40 mesh sieves, the cushioning liquid that the pH that adds 20 times of dry powder quality is 4.5, the cellulase effect that the sweet tea powder mass ratio of take under 45 ℃ is 0.8% 45 minutes, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim extract, the sweet tea of solid adds 70% ethanol that mass ratio is 28 times again, then 70 ℃ of lower lixiviates 80 minutes, filter, merge extract.Use the Vacuum Concentration extract, air drying obtains sweet tea chromocor extract powder.
Described auxiliary material is medical starch, citric acid, sweet mellow wine, vitamin C.
Described lubricant is talcum powder and dolomol, and essence is "Hami" melon essence and Mint Essence.
The sweet tea flavone lozenge that adopts the preparation method of sweet tea flavone lozenge of the present invention to make, the composition of this lozenge and quality percentage composition are:
Sweet tea chromocor extract powder 30~50%
Supplementary product starch 20~40%
Vitamin C 3~9%
Sweet mellow wine 20%
Citric acid 0.4%
Dolomol 0.5%
Talcum powder 1%
"Hami" melon essence 0.1%
Mint Essence 0.05%.
Compared with prior art, its substantive distinguishing features and marked improvement part are in the present invention:
1, adopt respectively Alcohol percolation, ethanol refluxing process, ultrasonic extraction, microbial enzyme extraction method to extract sweet tea chromocor extract, and retained a large amount of sweet theine as natural sweetener.
2, sweet tea chromocor extract is made to lozenge, instant edible.
The specific embodiment
Embodiment 1
Dry sweet tea is without pulverizing, adds 70% alcohol immersion 2 hours of 1 times of amount of its quality, then adds 70% ethanol percolation of 10 times of dry powder quality to extract, and the speed of diafiltration is 3 ml/min.The Vacuum Concentration percolate, air drying obtains medicinal extract.Then the baking oven of putting into 60~70 ℃ dry, pulverize, and crosses 60 mesh sieves, standby.Each auxiliary material was pulverized 100 mesh sieves, standby.Add sweet tea chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
Embodiment 2
Pulverize dry sweet tea and cross 40 mesh sieves, add 65% ethanol of 25 times of amounts of dry powder quality under the condition of 70 ℃, refluxing extraction 80 minutes, under the condition of 5000 rev/mins centrifugal 10 minutes, reclaim supernatant, residue uses 65% ethanol of equal in quality again under the condition of 70 ℃, refluxing extraction 80 minutes, repeat above operation, merge extract.The Vacuum Concentration extract, the baking oven of then putting into 50~60 ℃ dry, pulverize, and crosses 80 mesh sieves, standby.It is standby that each auxiliary material was pulverized 100 mesh sieves.Add chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, medicinal powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
Embodiment 3
Pulverize dry sweet tea and cross 50 mesh sieves, add 60% ethanol of 35 times of dry powder quality at room temperature to soak 2 hours, extract 30 minutes in ultrasonoscope 40 ℃ of waters of power with 60% under the 130W condition, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim supernatant, residue uses 60% ethanol of equal in quality again under the condition of 40 ℃, ultrasonic extraction 80 minutes, repeat above operation, merge extract.The Vacuum Concentration extract, the baking oven of then putting into 50~60 ℃ dry, pulverize, and crosses 80 mesh sieves, standby.It is standby that each auxiliary material was pulverized 100 mesh sieves.According to the film-making formula, add sweet tea chromocor extract powder and other auxiliary materials to be: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, sweet tea chromocor extract powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
Embodiment 4
Pulverize sweet tea and cross 60 mesh sieves, add 50% ethanol of 30 times of amounts of dry powder quality at room temperature to soak 1 hour, micro-wave oven general power 800W room temperature under 60% power condition is extracted 3 minutes, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim supernatant, residue uses 50% ethanol of equal in quality again under the condition of room temperature, Microwave Extraction 4 minutes, repeat above operation, merge extract.The Vacuum Concentration extract, air drying obtains medicinal extract.Then the baking oven of putting into 50~60 ℃ dry, pulverize, and crosses 80 mesh sieves, standby.It is standby that each auxiliary material was pulverized 100 mesh sieves.Add sweet tea chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea flavones chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, sweet tea chromocor extract powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
Embodiment 5
Pulverize sweet tea and cross 40 mesh sieves, the cushioning liquid that the pH that adds 20 times of amounts of dry powder quality is 4.5, the cellulase effect that the sweet tea powder mass ratio of take under 45 ℃ is 0.8% 45 minutes, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim extract, the sweet tea of solid adds 70% ethanol that mass ratio is 28 times again, then 70 ℃ of lower lixiviates 80 minutes, filter, merge extract.Use the Vacuum Concentration extract, the baking oven of then putting into 50~60 ℃ dry, pulverize, and crosses 80 mesh sieves, standby.It is standby that each auxiliary material was pulverized 100 mesh sieves.Add sweet tea chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, sweet tea chromocor extract powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
The fruity Rubus suavissimus flavone lozenge be prepared into by the method for the invention, its composition and quality percentage composition scope:
Sweet tea chromocor extract powder 30~50%
Supplementary product starch 20~40%
Vitamin C 3~9%
Sweet mellow wine 20%
Citric acid 0.4%
Dolomol 0.5%
Talcum powder 1%
"Hami" melon essence 0.1%
Mint Essence 0.05%.

Claims (5)

1. the preparation method of a fruity Rubus suavissimus flavone lozenge, comprise and add auxiliary material, softwood processed, granulate, dry, whole grain, then adding lubricant and essence mixes and the compressing tablet step, it is characterized in that: the method is that dry sweet tea is through pulverizing, 70% alcohol immersion 2 hours that adds 1 times of amount of its quality, add again 70% ethanol percolation of 10 times of dry powder quality to extract, the speed of diafiltration is 3 ml/min, the Vacuum Concentration percolate, air drying obtains medicinal extract, then the baking oven of putting into 60~70 ℃ is dry, pulverize, cross 60 mesh sieves, obtain sweet tea chromocor extract powder, standby, each auxiliary material was pulverized 100 mesh sieves, standby, add sweet tea chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
2. the preparation method of a fruity Rubus suavissimus flavone lozenge, comprise and add auxiliary material, softwood processed, granulate, dry, whole grain, then adding lubricant and essence mixes and the compressing tablet step, it is characterized in that: the method is to pulverize dry sweet tea to cross 40 mesh sieves, add 65% ethanol of 25 times of amounts of dry powder quality under the condition of 70 ℃, refluxing extraction 80 minutes, under the condition of 5000 rev/mins centrifugal 10 minutes, reclaim supernatant, residue uses 65% ethanol of equal in quality again under the condition of 70 ℃, refluxing extraction 80 minutes, repeat above operation, merge extract, the Vacuum Concentration extract, then the baking oven of putting into 50~60 ℃ is dry, pulverize, cross 80 mesh sieves, obtain sweet tea chromocor extract powder, standby, it is standby that each auxiliary material was pulverized 100 mesh sieves, add chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, medicinal powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
3. the preparation method of a fruity Rubus suavissimus flavone lozenge, comprise and add auxiliary material, softwood processed, granulate, dry, whole grain, then adding lubricant and essence mixes and the compressing tablet step, it is characterized in that: the method is to pulverize dry sweet tea to cross 50 mesh sieves, add 60% ethanol of 35 times of dry powder quality at room temperature to soak 2 hours, extract 30 minutes in ultrasonoscope 40 ℃ of waters of power with 60% under the 130W condition, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim supernatant, residue uses 60% ethanol of equal in quality again under the condition of 40 ℃, ultrasonic extraction 80 minutes, repeat above operation, merge extract, the Vacuum Concentration extract, then the baking oven of putting into 50~60 ℃ is dry, pulverize, cross 80 mesh sieves, obtain sweet tea chromocor extract powder, standby, it is standby that each auxiliary material was pulverized 100 mesh sieves, according to the film-making formula, add sweet tea chromocor extract powder and other auxiliary materials to be: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, sweet tea chromocor extract powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
4. the preparation method of a fruity Rubus suavissimus flavone lozenge, comprise and add auxiliary material, softwood processed, granulate, dry, whole grain, then adding lubricant and essence mixes and the compressing tablet step, it is characterized in that: the method is to pulverize sweet tea to cross 60 mesh sieves, add 50% ethanol of 30 times of amounts of dry powder quality at room temperature to soak 1 hour, micro-wave oven general power 800W room temperature under 60% power condition is extracted 3 minutes, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim supernatant, residue uses 50% ethanol of equal in quality again under the condition of room temperature, Microwave Extraction 4 minutes, repeat above operation, merge extract, the Vacuum Concentration extract, air drying obtains medicinal extract, then the baking oven of putting into 50~60 ℃ is dry, pulverize, cross 80 mesh sieves, obtain sweet tea chromocor extract powder, standby, it is standby that each auxiliary material was pulverized 100 mesh sieves, add sweet tea chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, sweet tea chromocor extract powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
5. the preparation method of a fruity Rubus suavissimus flavone lozenge, comprise and add auxiliary material, softwood processed, granulate, dry, whole grain, then adding lubricant and essence mixes and the compressing tablet step, it is characterized in that: the method is to pulverize sweet tea to cross 40 mesh sieves, the cushioning liquid that the pH that adds 20 times of amounts of dry powder quality is 4.5, the cellulase effect that the sweet tea powder mass ratio of take under 45 ℃ is 0.8% 45 minutes, under 5000 rev/mins of conditions centrifugal 10 minutes, reclaim extract, the sweet tea of solid adds 70% ethanol that mass ratio is 28 times again, again 70 ℃ of lower lixiviates 80 minutes, filter, merge extract, use the Vacuum Concentration extract, then the baking oven of putting into 50~60 ℃ is dry, pulverize, cross 80 mesh sieves, obtain sweet tea chromocor extract powder, standby, it is standby that each auxiliary material was pulverized 100 mesh sieves, add sweet tea chromocor extract powder and other auxiliary materials according to the film-making formula: sweet tea chromocor extract powder 40%, supplementary product starch 38.75%, vitamin C 5%, sweet mellow wine 14.7%, citric acid 0.4%, dolomol 0.5%, talcum powder 1%, "Hami" melon essence 0.1%, Mint Essence 0.05%, sweet tea chromocor extract powder is mixed with auxiliary material, make according to a conventional method fruity Rubus suavissimus flavone lozenge.
CN2010101584986A 2010-04-28 2010-04-28 Preparation method of fruity Rubus suavissimus flavone lozenge Expired - Fee Related CN101861988B (en)

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CN102860386A (en) * 2012-09-11 2013-01-09 南昌大学 Preparation method of tea extractive lozenge
CN103416754B (en) * 2013-08-26 2015-09-16 贵州省健康茶科技有限公司 A kind of Sweet-tea tooth protection lozenge
CN105412168A (en) * 2015-12-22 2016-03-23 桂林双象生物科技有限公司 Preparation method of sweet tea and gingko composite original tea
CN106804816A (en) * 2017-01-16 2017-06-09 广州大浦金医药科技有限公司 Tea buccal tablet and preparation method thereof
CN108936668A (en) * 2018-09-14 2018-12-07 楚雄师范学院 A kind of open country embankment buccal tablet and preparation method thereof
CN110904081B (en) * 2019-11-20 2021-07-30 江苏省中国科学院植物研究所 Endo-glucanase RuEG6 and coding gene and application thereof

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Publication number Priority date Publication date Assignee Title
CN101669641A (en) * 2009-09-23 2010-03-17 上海应用技术学院 Fruit flavored sweet tea chewable tablets and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101669641A (en) * 2009-09-23 2010-03-17 上海应用技术学院 Fruit flavored sweet tea chewable tablets and preparation method thereof

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