CN116326689A - 一种母子协同预防犊牛腹泻的饲料添加物及其应用 - Google Patents
一种母子协同预防犊牛腹泻的饲料添加物及其应用 Download PDFInfo
- Publication number
- CN116326689A CN116326689A CN202310304376.0A CN202310304376A CN116326689A CN 116326689 A CN116326689 A CN 116326689A CN 202310304376 A CN202310304376 A CN 202310304376A CN 116326689 A CN116326689 A CN 116326689A
- Authority
- CN
- China
- Prior art keywords
- feed additive
- parts
- calf
- cow
- portions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000309466 calf Species 0.000 title claims abstract description 121
- 239000003674 animal food additive Substances 0.000 title claims abstract description 86
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 46
- 241000283690 Bos taurus Species 0.000 claims abstract description 52
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 235000005911 diet Nutrition 0.000 claims abstract description 16
- 230000037213 diet Effects 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 16
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 15
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 15
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 15
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 13
- 235000011477 liquorice Nutrition 0.000 claims abstract description 13
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 9
- 229930006000 Sucrose Natural products 0.000 claims abstract description 9
- 239000005862 Whey Substances 0.000 claims abstract description 9
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 9
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 9
- 229920001277 pectin Polymers 0.000 claims abstract description 9
- 235000010987 pectin Nutrition 0.000 claims abstract description 9
- 239000001814 pectin Substances 0.000 claims abstract description 9
- 239000005720 sucrose Substances 0.000 claims abstract description 9
- 240000000724 Berberis vulgaris Species 0.000 claims abstract description 8
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 8
- 244000237330 gutta percha tree Species 0.000 claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims abstract description 8
- 235000013379 molasses Nutrition 0.000 claims abstract description 7
- 230000009984 peri-natal effect Effects 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 241000756943 Codonopsis Species 0.000 claims abstract description 3
- 240000001949 Taraxacum officinale Species 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 13
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 8
- 229910000278 bentonite Inorganic materials 0.000 claims description 8
- 239000000440 bentonite Substances 0.000 claims description 8
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 8
- 235000008397 ginger Nutrition 0.000 claims description 8
- 239000008188 pellet Substances 0.000 claims description 8
- 210000005253 yeast cell Anatomy 0.000 claims description 8
- 241000205585 Aquilegia canadensis Species 0.000 claims description 7
- 241001061264 Astragalus Species 0.000 claims description 7
- 235000006533 astragalus Nutrition 0.000 claims description 7
- 239000008159 sesame oil Substances 0.000 claims description 7
- 235000011803 sesame oil Nutrition 0.000 claims description 7
- 238000007873 sieving Methods 0.000 claims description 7
- 210000004233 talus Anatomy 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- 241000132012 Atractylodes Species 0.000 claims description 6
- 244000062241 Kaempferia galanga Species 0.000 claims description 6
- 235000013421 Kaempferia galanga Nutrition 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- 241000123887 Pulsatilla chinensis Species 0.000 claims description 5
- 235000014590 basal diet Nutrition 0.000 claims description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 claims description 2
- 239000000944 linseed oil Substances 0.000 claims description 2
- 235000021388 linseed oil Nutrition 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 239000006052 feed supplement Substances 0.000 claims 6
- 240000002045 Guettarda speciosa Species 0.000 claims 1
- 244000116484 Inula helenium Species 0.000 claims 1
- 235000002598 Inula helenium Nutrition 0.000 claims 1
- 244000273928 Zingiber officinale Species 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 210000003022 colostrum Anatomy 0.000 abstract description 12
- 235000021277 colostrum Nutrition 0.000 abstract description 12
- 230000036039 immunity Effects 0.000 abstract description 8
- 244000061520 Angelica archangelica Species 0.000 abstract description 7
- 241000972672 Phellodendron Species 0.000 abstract description 5
- 230000029087 digestion Effects 0.000 abstract description 5
- 235000020247 cow milk Nutrition 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 239000011885 synergistic combination Substances 0.000 abstract description 2
- 239000009636 Huang Qi Substances 0.000 abstract 1
- -1 premix Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 14
- 241000245665 Taraxacum Species 0.000 description 12
- 241000234314 Zingiber Species 0.000 description 7
- 230000001737 promoting effect Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- 231100000517 death Toxicity 0.000 description 5
- 210000003608 fece Anatomy 0.000 description 5
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 5
- 229940107187 fructooligosaccharide Drugs 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 241000007126 Codonopsis pilosula Species 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 235000019621 digestibility Nutrition 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 239000010871 livestock manure Substances 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 239000011265 semifinished product Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 230000006651 lactation Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 235000019750 Crude protein Nutrition 0.000 description 2
- 208000035240 Disease Resistance Diseases 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 241000206469 Pulsatilla Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 208000010643 digestive system disease Diseases 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 235000021049 nutrient content Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 240000004510 Agastache rugosa Species 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 206010004016 Bacterial diarrhoea Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 206010012742 Diarrhoea infectious Diseases 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 241000576429 Forsythia suspensa Species 0.000 description 1
- 241000212322 Levisticum officinale Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000003805 Musa ABB Group Nutrition 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241001522129 Pinellia Species 0.000 description 1
- 235000015266 Plantago major Nutrition 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 240000003152 Rhus chinensis Species 0.000 description 1
- 235000014220 Rhus chinensis Nutrition 0.000 description 1
- 241001180876 Saposhnikovia Species 0.000 description 1
- 241000915604 Scutellaria barbata Species 0.000 description 1
- 206010051511 Viral diarrhoea Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000004913 chyme Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000023011 digestive tract development Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000001645 levisticum officinale Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 201000003102 mental depression Diseases 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000003170 nutritional factors Nutrition 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
- A23K10/28—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin from waste dairy products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/33—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from molasses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
本发明公开了一种母子协同预防犊牛腹泻的饲料添加物及其应用，在母牛围产期期间将母牛饲料添加物添加到母牛基础饲粮中，添加量为0.2~0.8%，一日一次；在犊牛0~30日龄期间将犊牛饲料添加物添加到犊牛基础饲粮中，添加量为1.5~2.5%，一日一次；所述母牛饲料添加物由以下组分制成：党参、黄芪、当归、川芍药、王不留行、小檗、黄柏、连翘、半枝莲、蒲公英、杜仲、甘草、糖蜜；所述犊牛饲料添加物由以下组分制成：中药组合物、预混物、果胶、蔗糖、乳清粉、胡麻油；其中母牛饲料添加物能够减少母牛牛乳中有害菌含量，并提高初乳产量和质量；犊牛饲料添加物能够提高犊牛免疫力、消化能力，二者协同配合能够显著降低犊牛腹泻率。
Description
技术领域
本发明涉及犊牛养殖技术领域，具体涉及一种母子协同预防犊牛腹泻的饲料添加物及其应用。
背景技术
犊牛断奶前死亡主要集中于消化系统和呼吸系统疾病，消化系统疾病占62.1％、呼吸系统疾病占21.3％、其他疾病仅占16.6％，这些疾病大多在犊牛21日龄以内出现。
犊牛腹泻是犊牛发生的以消化不良、腹泻为主要症状的消化道疾病综合征；多发于断奶前犊牛，以1月龄内犊牛最为常见，临床症状为排稀粪、水样粪或血粪等，常伴随采食减少、精神沉郁、脱水和体型消瘦等全身性症状；犊牛腹泻会造成后备母牛生长缓慢、生产性能下降和免疫力低下等，增加饲养和治疗成本，严重制约牧场良种选育和牛群扩繁，给奶牛和肉牛养殖业带来巨大的经济损失。
犊牛腹泻发病率很高，尤其在出生后的前三周，尽管大多数养殖场都会采取一定的预防措施，但犊牛腹泻依然是断奶前犊牛死亡的主要原因之一；世界范围内犊牛腹泻的发病率为20～100％，部分养殖场可达90～100％；犊牛腹泻是断奶前犊牛死亡的主要原因，据美国乳业国家动物健康监测系统报告称，美国39％的犊牛死亡是犊牛腹泻引起的，韩国为53.4％；可引起犊牛腹泻的原因较多，包括感染性因素、营养性因素和环境因素等，其中感染性因素是引起犊牛腹泻的主要原因；根据病原种类可将感染性腹泻分为三类：病毒性腹泻、细菌性腹泻和寄生虫性腹泻。
中国专利文献CN104799110A公开了一种缓解犊牛腹泻率的饲料添加剂，车前草、葛根、黄连、干姜、木香、山药、当归、白芍、川穹、防风、藿香和半夏组成，具有清热解毒，燥湿止泻，升阳理气之功效，能够显著缓解犊牛腹泻的症状，按重量百分比为1％的比例添加到犊牛精料中，搅拌均匀后即可直接饲喂。但实际应用过程中发现该饲料添加剂对犊牛腹泻的治疗效果欠佳。
犊牛健康及高效生长依赖于良好的初乳管理，初乳是影响犊牛健康及成活率的最重要因素，初乳不仅含有抗体，还是犊牛出生后首次充足的营养来源。犊牛刚出生时大肠感染很容易通过母乳垂直传递给犊牛，初生犊牛抵抗力较差，大肠杆菌会形成较多有毒性的有害物质，对犊牛胃肠道产生刺激，从而导致犊牛出现不良反应，致使犊牛消化和利用乳汁、饲料的能力明显降低，最终导致犊牛腹泻；因此急需提供一种能够降低母牛乳汁中致病菌含量，减少母乳对犊牛的垂直感染，并能够提高犊牛免疫力、有效预防犊牛腹泻的母子协同饲料添加物。
发明内容
为了解决现有技术存在的不足，本发明的目的在于提供一种母子协同预防犊牛腹泻的饲料添加物及其应用，能够降低母牛乳汁中致病菌含量，并增加初乳产量和质量，帮助提高犊牛免疫力，从而有效预防犊牛腹泻。
为了实现上述目的，本发明采用如下技术方案：
一种母子协同预防犊牛腹泻的饲料添加物，包括母牛饲料添加物和犊牛饲料添加物。
优选的，所述母牛饲料添加物的制备方法如下：按重量份称取党参20～30份、黄芪20～30份、当归15～25份、川芍药15～25份、王不留行15～25份、小檗10～20份、黄柏10～20份、连翘8～15份、半枝莲8～15份、蒲公英8～15份、杜仲8～15份、甘草5～10份，在50～70℃下烘干，粉碎、过20～40目筛，得到中药粉，然后加入糖蜜20～50份，混合均匀，得到母牛饲料添加物。
优选的，以重量份数计，所述犊牛饲料添加物由以下组分制成：中药组合物100份、预混物80～100份、果胶40～60份、蔗糖15～30份、乳清粉15～30份、胡麻油5～10份。
优选的，所述中药组合物的制备方法如下：按重量份称取蒲公英10～20份、白头翁5～10份、金银花15～25份、白术15～25份、陈皮15～25份、木香15～25份、山奈10～20份、乌梅10～20份、五倍子10～20份、泽泻8～15份、生姜8～15份、甘草5～10份，在50～70℃下烘干，粉碎、过20～40目筛，混合均匀，得到中药组合物。
优选的，所述预混物由膨润土、酵母细胞壁、博维康、果寡糖按重量比1：1：2～3：1～2混合均匀制成。
优选的，所述犊牛饲料添加物的制备方法如下：
将中药组合物加入到65wt％乙醇中煎煮三次，每次40～60min，过滤并浓缩，得到浸膏；将浸膏与预混物混合均匀，然后加入果胶、蔗糖、乳清粉、胡麻油，制成软材，投入挤条机中挤条，将条状半成品投入滚圆机中制成微丸，干燥，得到犊牛饲料添加物。
优选的，中药组合物与65wt％乙醇的重量体积比为1：8～10；将微丸干燥至水分为0.5～1％。
本发明还要求保护一种所述饲料添加物在预防犊牛腹泻中的应用，在母牛围产期期间将母牛饲料添加物添加到母牛基础饲粮中，一日一次；在犊牛0～30日龄期间将犊牛饲料添加物添加到犊牛基础饲粮中，一日一次。
优选的，所述母牛饲料添加物在母牛基础饲粮中的添加量为0.2～0.8％。
优选的，所述犊牛饲料添加物在犊牛基础饲粮中的添加量为1.5～2.5％。
与现有技术相比，本发明具有如下有益效果：
1)本发明提供了一种母子协同预防犊牛腹泻的饲料添加物及其应用，其中母牛饲料添加物能够减少母牛牛乳中有害菌含量，并提高初乳产量，增加初乳免疫蛋白含量；犊牛饲料添加物能够提高犊牛免疫力、提高犊牛采食量和消化能力，二者协同配合能够提高犊牛抗病能力，显著降低犊牛腹泻率。
2)本发明提供了一种母子协同预防犊牛腹泻的饲料添加物及其应用，母牛饲料添加物中，党参、黄芪、当归，甘温补润、补血益气，能够增强机体免疫功能，抗病毒、抗氧化、消炎镇痛；川芍药，活血通经，凉血散瘀；小檗、黄柏、连翘、半枝莲，清热解毒、抗毒消炎，有效抗病原微生物，增强免疫功能；蒲公英、杜仲，消炎镇痛，增强抗氧化应激和抗病能力；王不留行，活血通经，下乳消肿，能够增加母牛泌乳量；甘草，补脾益气，清热解毒，调和百药；本发明提供的母牛饲料添加物，一方面能使生产后母牛迅速恢复、增加泌乳量，同时还起到抗菌消炎作用，能够抑制或灭杀牛乳中的大肠杆菌等致病菌，提升初乳中IgG含量，能够帮助建立提升犊牛免疫能力。
3)本发明提供了一种母子协同预防犊牛腹泻的饲料添加物及其应用，犊牛饲料添加物中，各草药互相调和发挥协同作用，蒲公英、白头翁、金银花，清热燥湿、泻火解毒、凉血止痢，具有抗病原微生物、增强免疫功能、抗炎等作用；白术、陈皮、木香、山奈，健脾益气、行气止痛，具有促进消化系统、增强免疫功能、抗氧化等功能；乌梅，生津止渴、涩肠止泻；五倍子，敛肺降火、涩肠止泻；泽泻，利水渗湿、泄热通淋；生姜，解表散寒、醒脾和胃、温中止呕；甘草，补脾益气、和中缓急、调和百药；整方起到调整阴阳、补虚健脾、利水渗湿、祛积消食、行气止痛与温中止泻之效。
4)本发明提供了一种母子协同预防犊牛腹泻的饲料添加物及其应用，预混物由膨润土、酵母细胞壁、博维康、果寡糖制成，通过合理复配，可延长食糜在消化道内的滞留时间、降低胃肠道消化道pH，促进肠道内有益菌增殖，改变肠道微生态环境，促进犊牛肠道发育、修复胃黏膜，提高犊牛的消化吸收能力、机体免疫力、抗应激能力，不仅能显著提高犊牛对日粮的消化利用，还能降低犊牛腹泻的发生。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚，以下结合实施例，对本发明作进一步的详细说明。当然，此处所描述的具体实施例仅仅用于解释本发明，并不用于限定本发明。
如无特殊说明外，本发明中的化学试剂和材料均通过市场途径购买或通过市场途径购买的原料合成。
膨润土购自石家庄林诚矿产品贸易有限公司，目数200目；
酵母细胞壁、博维康由长春博瑞科技股份有限公司提供；
胡麻油购自内蒙古益善园生物科技有限责任公司；
果寡糖购自山东富禾生物科技有限公司，含量>95％，CAS：57-48-7；
各味中药均购自国药大药房。
实施例1
一种饲料添加物在预防犊牛腹泻中的应用，母牛饲料添加物在母牛围产期期间添加到母牛基础饲粮中，添加量为0.8％，一日一次；犊牛饲料添加物在犊牛0～30日龄期间添加到犊牛基础饲粮中，添加量为2.5％，一日一次。
母牛饲料添加物的制备方法如下：按重量份称取党参300g、黄芪300g、当归250g、川芍药250g、王不留行250g、小檗200g、黄柏200g、连翘150g、半枝莲150g、蒲公英150g、杜仲150g、甘草100g，在70℃下烘干，粉碎、过40目筛，得到中药粉，然后加入糖蜜500g，混合均匀，得到母牛饲料添加物。
所述犊牛饲料添加物的制备方法如下：
(1)按重量份称取蒲公英200g、白头翁100g、金银花250g、白术250g、陈皮250g、木香250g、山奈200g、乌梅200g、五倍子200g、泽泻150g、生姜150g、甘草100g，在70℃下烘干，粉碎、过40目筛，混合均匀，得到中药组合物；
(2)将膨润土、酵母细胞壁、博维康、果寡糖按重量比1：1：2：1混合均匀，得到预混物，备用；
(3)将1000g中药组合物加入到10000mL 65wt％乙醇中煎煮三次，每次60min，过滤并浓缩，得到相对密度1.13的浸膏；将浸膏与1000g预混物混合均匀，然后加入600g果胶、300g蔗糖、300g乳清粉、100g胡麻油，制成软材，投入挤条机中挤条，将条状半成品投入滚圆机中制成微丸，干燥至水分为1％，得到犊牛饲料添加物。
实施例2
一种饲料添加物在预防犊牛腹泻中的应用，母牛饲料添加物在母牛围产期期间添加到母牛基础饲粮中，添加量为0.2％，一日一次；犊牛饲料添加物在犊牛0～30日龄期间添加到犊牛基础饲粮中，添加量为1.5％，一日一次。
母牛饲料添加物的制备方法如下：按重量份称取党参200g、黄芪200g、当归150g、川芍药150g、王不留行150g、小檗100g、黄柏100g、连翘80g、半枝莲80g、蒲公英80g、杜仲80g、甘草50g，在50℃下烘干，粉碎、过20目筛，得到中药粉，然后加入糖蜜200g，混合均匀，得到母牛饲料添加物。
所述犊牛饲料添加物的制备方法如下：
(1)按重量份称取蒲公英100g、白头翁50g、金银花150g、白术150g、陈皮150g、木香150g、山奈100g、乌梅100g、五倍子100g、泽泻80g、生姜80g、甘草50g，在50℃下烘干，粉碎、过20目筛，混合均匀，得到中药组合物；
(2)将膨润土、酵母细胞壁、博维康、果寡糖按重量比1：1：2：1混合均匀，得到预混物，备用；
(3)将1000g中药组合物加入到8000mL 65wt％乙醇中煎煮三次，每次40min，过滤并浓缩，得到相对密度1.13的浸膏；将浸膏与800g预混物混合均匀，然后加入400g果胶、150g蔗糖、150g乳清粉、50g胡麻油，制成软材，投入挤条机中挤条，将条状半成品投入滚圆机中制成微丸，干燥至水分为0.5％，得到犊牛饲料添加物。
实施例3
一种饲料添加物在预防犊牛腹泻中的应用，母牛饲料添加物在母牛围产期期间添加到母牛基础饲粮中，添加量为0.5％，一日一次；犊牛饲料添加物在犊牛0～30日龄期间添加到犊牛基础饲粮中，添加量为2％，一日一次。
母牛饲料添加物的制备方法如下：按重量份称取党参250g、黄芪250g、当归200g、川芍药200g、王不留行200g、小檗150g、黄柏150g、连翘100g、半枝莲100g、蒲公英100g、杜仲100g、甘草80g，在60℃下烘干，粉碎、过40目筛，得到中药粉，然后加入糖蜜400g，混合均匀，得到母牛饲料添加物。
所述犊牛饲料添加物的制备方法如下：
(1)按重量份称取蒲公英150g、白头翁70g、金银花200g、白术200g、陈皮200g、木香200g、山奈150g、乌梅150g、五倍子150g、泽泻100g、生姜100g、甘草80g，在60℃下烘干，粉碎、过40目筛，混合均匀，得到中药组合物；
(2)将膨润土、酵母细胞壁、博维康、果寡糖按重量比1：1：2：1混合均匀，得到预混物，备用；
(3)将1000g中药组合物加入到9000mL 65wt％乙醇中煎煮三次，每次50min，过滤并浓缩，得到相对密度1.13的浸膏；将浸膏与900g预混物混合均匀，然后加入500g果胶、200g蔗糖、200g乳清粉、80g胡麻油，制成软材，投入挤条机中挤条，将条状半成品投入滚圆机中制成微丸，干燥至水分为0.8％，得到犊牛饲料添加物。
对比例1
一种饲料添加物在预防犊牛腹泻中的应用，犊牛饲料添加物在犊牛1～60日龄期间添加到犊牛基础饲粮中，添加量为2.5％，一日一次。
犊牛饲料添加物的制备方法如下：
(1)按重量份称取蒲公英200g、白头翁100g、金银花250g、白术250g、陈皮250g、木香250g、山奈200g、乌梅200g、五倍子200g、泽泻150g、生姜150g、甘草100g，在70℃下烘干，粉碎、过40目筛，混合均匀，得到中药组合物；
(2)将膨润土、酵母细胞壁、博维康、果寡糖按重量比1：1：2：1混合均匀，得到预混物，备用；
(3)将1000g中药组合物加入到10000mL 65wt％乙醇中煎煮三次，每次60min，过滤并浓缩，得到相对密度1.13的浸膏；将浸膏与1000g预混物混合均匀，然后加入600g果胶、300g蔗糖、300g乳清粉、100g胡麻油，制成软材，投入挤条机中挤条，将条状半成品投入滚圆机中制成微丸，干燥至水分为1％，得到犊牛饲料添加物。
对比例2
一种饲料添加物在预防犊牛腹泻中的应用，母牛饲料添加物在围产期期间添加到母牛基础饲粮中，添加量为0.8％，一日一次。
母牛饲料添加物的制备方法如下：按重量份称取党参300g、黄芪300g、当归250g、川芍药250g、王不留行250g、小檗200g、黄柏200g、连翘150g、半枝莲150g、蒲公英150g、杜仲150g、甘草100g，在70℃下烘干，粉碎、过40目筛，得到中药粉，然后加入糖蜜500g，混合均匀，得到母牛饲料添加物。
选择50头健康状况相近、胎次为2的围产期母牛，从母牛分娩前30天开始实验，实验持续至犊牛30日龄当天，实验期间，母牛分娩前30天每天向母牛基础饲粮中添加母牛饲料添加物，犊牛生产后向0～30日龄期间向犊牛基础饲粮中添加犊牛饲料添加物。
记录实验期间不同组中试验犊牛腹泻发病次数以及死亡头数，具体数据见表1。
表1饲料添加物对犊牛腹泻的影响
母牛产后0～3h内收集初乳，并测定初乳的各指标参数，初乳IgG采用IgG ELISA试剂盒检测，大肠埃希氏菌数的测定参照GB 4789.38-2012《食品安全国家标准食品微生物学检验大肠埃希氏菌计数》，具体数据见表2。
表2初乳指标参数
| 实施例1 | 实施例2 | 实施例3 | 对比例1 | |
| 产量/L | 6.2 | 5.8 | 6.0 | 4.9 |
| IgG含量/(mg/mL) | 85 | 76 | 86 | 47 |
| 大肠杆菌/(×104CFU/mL) | 5.6±1.1 | 6.3±0.9 | 5.4±0.7 | 13.2±2.1 |
试验结束前3天，每组随机选取5头犊牛，收集犊牛粪便，每日收集10％；利用内源指示剂法测定营养物质表观消化率，以酸不溶灰分(AIA)为指示剂，计算干物质(DM)、粗蛋白(CP)、中性洗涤纤维(NDF)、酸性洗涤纤维(ADF)、钙(Ca)、磷(P)的表观消化率。
营养物质表观消化率(％)＝1－100×[(饲料中养分含量/饲料中AIA含量－粪中养分含量/粪中AIA含量)/(饲料中养分含量/饲料中AIA含量)]
表3饲料添加物对犊牛营养物质表观消化率的影响(单位：％)
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (10)
1.一种母子协同预防犊牛腹泻的饲料添加物，其特征在于，包括母牛饲料添加物和犊牛饲料添加物。
2.根据权利要求1所述的饲料添加物，其特征在于，所述母牛饲料添加物的制备方法如下：按重量份称取党参20~30份、黄芪20~30份、当归15~25份、川芍药15~25份、王不留行15~25份、小檗10~20份、黄柏10~20份、连翘8~15份、半枝莲8~15份、蒲公英8~15份、杜仲8~15份、甘草5~10份，在50~70℃下烘干，粉碎、过20~40目筛，得到中药粉，然后加入糖蜜20~50份，混合均匀，得到母牛饲料添加物。
3.根据权利要求1所述的饲料添加物，其特征在于，以重量份数计，所述犊牛饲料添加物由以下组分制成：中药组合物100份、预混物80~100份、果胶40~60份、蔗糖15~30份、乳清粉15~30份、胡麻油5~10份。
4.根据权利要求3所述的饲料添加物，其特征在于，所述中药组合物的制备方法如下：按重量份称取蒲公英10~20份、白头翁5~10份、金银花15~25份、白术15~25份、陈皮15~25份、木香15~25份、山奈10~20份、乌梅10~20份、五倍子10~20份、泽泻8~15份、生姜8~15份、甘草5~10份，在50~70℃下烘干，粉碎、过20~40目筛，混合均匀，得到中药组合物。
5.根据权利要求3所述的饲料添加物，其特征在于，所述预混物由膨润土、酵母细胞壁、博维康、果寡糖按重量比1：1：2~3：1~2混合均匀制成。
6.根据权利要求3所述的饲料添加物，其特征在于，所述犊牛饲料添加物的制备方法如下：
将中药组合物加入到65wt%乙醇中煎煮三次，每次40~60min，过滤并浓缩，得到浸膏；将浸膏与预混物混合均匀，然后加入果胶、蔗糖、乳清粉、胡麻油，制成软材，投入挤条机中挤条，将条状半成品投入滚圆机中制成微丸，干燥，得到犊牛饲料添加物。
7.根据权利要求6所述的饲料添加物，其特征在于，中药组合物与65wt%乙醇的重量体积比为1：8~10；将微丸干燥至水分为0.5~1%。
8.一种利用权利要求1~7任一项所述饲料添加物在预防犊牛腹泻中的应用，其特征在于，在母牛围产期期间将母牛饲料添加物添加到母牛基础饲粮中，一日一次；在犊牛0~30日龄期间将犊牛饲料添加物添加到犊牛基础饲粮中，一日一次。
9.根据权利要求8所述的应用，其特征在于，所述母牛饲料添加物在母牛基础饲粮中的添加量为0.2~0.8%。
10.根据权利要求8所述的应用，其特征在于，所述犊牛饲料添加物在犊牛基础饲粮中的添加量为1.5~2.5%。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310304376.0A CN116326689A (zh) | 2023-03-27 | 2023-03-27 | 一种母子协同预防犊牛腹泻的饲料添加物及其应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310304376.0A CN116326689A (zh) | 2023-03-27 | 2023-03-27 | 一种母子协同预防犊牛腹泻的饲料添加物及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116326689A true CN116326689A (zh) | 2023-06-27 |
Family
ID=86881872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310304376.0A Pending CN116326689A (zh) | 2023-03-27 | 2023-03-27 | 一种母子协同预防犊牛腹泻的饲料添加物及其应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116326689A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117244037A (zh) * | 2023-10-11 | 2023-12-19 | 宁夏大学 | 一种防治犊牛转场运输应激组合物及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109770078A (zh) * | 2019-02-21 | 2019-05-21 | 山东省农业科学院畜牧兽医研究所 | 一种预防哺乳期犊牛腹泻的饲料添加剂及其使用方法 |
| AU2020104015A4 (en) * | 2020-11-03 | 2021-02-18 | Guizhou Institute Of Animal Husbandry And Veterinary Medicine | A green functional feed for improving growth performance and immunity of calves and its preparation method |
-
2023
- 2023-03-27 CN CN202310304376.0A patent/CN116326689A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109770078A (zh) * | 2019-02-21 | 2019-05-21 | 山东省农业科学院畜牧兽医研究所 | 一种预防哺乳期犊牛腹泻的饲料添加剂及其使用方法 |
| AU2020104015A4 (en) * | 2020-11-03 | 2021-02-18 | Guizhou Institute Of Animal Husbandry And Veterinary Medicine | A green functional feed for improving growth performance and immunity of calves and its preparation method |
Non-Patent Citations (3)
| Title |
|---|
| 孔雪旺: "怎样提高母牛繁殖效益", vol. 1, 31 May 2021, 机械工业出版社, pages: 117 - 118 * |
| 王正芳: "实用中医保健", vol. 1, 28 February 1990, 中国医药科技出版社, pages: 103 * |
| 郑虎占，等: "中药合理应用二十讲", vol. 1, 30 June 2014, 中国中医药出版社, pages: 89 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117244037A (zh) * | 2023-10-11 | 2023-12-19 | 宁夏大学 | 一种防治犊牛转场运输应激组合物及其制备方法 |
| CN117244037B (zh) * | 2023-10-11 | 2024-04-09 | 宁夏大学 | 一种防治犊牛转场运输应激组合物及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102669496B (zh) | 一种含蒙脱石肉鸡1-21日龄配合饲料及其制备方法 | |
| CN103478496B (zh) | 一种犬猫用泌尿道健康维护营养保健粮及其制作方法 | |
| CN109770078B (zh) | 一种预防哺乳期犊牛腹泻的饲料添加剂及其使用方法 | |
| CN103431228B (zh) | 一种仔猪饲料添加剂及其应用 | |
| CN102526525B (zh) | 一种用于治疗猪传染性胃肠炎的中药组合物 | |
| CN104886345A (zh) | 一种预防断奶仔猪腹泻的中药制剂及其制备方法 | |
| CN103230574B (zh) | 一种治疗猪流行性腹泻的中药组合物及其应用 | |
| CN105394385A (zh) | 一种预防断奶仔猪应激综合症的中药制剂及其制备方法 | |
| CN109527260B (zh) | 一种禽用复合型生物活性饲料添加剂及其制备方法 | |
| CN116326689A (zh) | 一种母子协同预防犊牛腹泻的饲料添加物及其应用 | |
| CN111789190A (zh) | 一种提高动物机体免疫力的中药饲料添加剂、饲料及制备方法 | |
| CN102895355B (zh) | 一种治疗家畜腹泻中药注射剂及其制备方法 | |
| CN102973702B (zh) | 一种用于治疗仔猪黄白痢的复方中药组合物及其制备方法 | |
| CN105816563B (zh) | 一种中药组合物在制备提高母猪繁殖性能药物中的应用 | |
| CN103191400B (zh) | 一种防治猪传染性胃肠炎的中药复方药物 | |
| CN112057517A (zh) | 一种用于提高断奶后仔猪成活率的中药组合物、制备方法以及饲喂方法 | |
| CN105902760B (zh) | 一种治疗兔胃肠炎的中药 | |
| CN110812389A (zh) | 一种提高猪免疫力的可溶性颗粒剂及其制备方法 | |
| CN115845004B (zh) | 一种用于治疗猪腹泻的中药微囊及其制备方法 | |
| CN107960535A (zh) | 一种防治肉牛胃肠炎的饲料添加剂及其生产方法 | |
| CN114191510B (zh) | 用于防治仔猪腹泻的中药复方制剂及其制备方法 | |
| CN115006488B (zh) | 一种防治家禽腺、肌胃炎的药物组合物及其制备方法与应用 | |
| CN110420301B (zh) | 一种用于治疗仔猪断奶腹泻的中药组合物及其制备方法 | |
| CN106822715A (zh) | 一种预防山羊布鲁氏杆菌病的组合物及其制备方法 | |
| CN106552035A (zh) | 一种医治大家畜冷肠泄泻方剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20230916 Address after: 750001 South side of Hanguan Road and east side of Hanhai Street, Suyin Industrial Park, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region Applicant after: Ningxia Borui Feed Co.,Ltd. Applicant after: Ningxia Borui Ruminant Nutrition Research Center Co.,Ltd. Address before: 750001 South side of Hanguan Road and east side of Hanhai Street, Suyin Industrial Park, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region Applicant before: Ningxia Borui Feed Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| CB02 | Change of applicant information |
Country or region after: China Address after: 750001 South side of Hanguan Road and east side of Hanhai Street, Suyin Industrial Park, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region Applicant after: Ningxia Borui Technology Co.,Ltd. Applicant after: Ningxia Ruminant Seed Research Technology Co.,Ltd. Address before: 750001 South side of Hanguan Road and east side of Hanhai Street, Suyin Industrial Park, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region Applicant before: Ningxia Borui Feed Co.,Ltd. Country or region before: China Applicant before: Ningxia Borui Ruminant Nutrition Research Center Co.,Ltd. |
|
| CB02 | Change of applicant information |