CN116322741A - 具有改善的胰淀素受体(hAMY3R)效力的hAM15-52类似物 - Google Patents

具有改善的胰淀素受体(hAMY3R)效力的hAM15-52类似物 Download PDF

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Publication number
CN116322741A
CN116322741A CN202180056599.9A CN202180056599A CN116322741A CN 116322741 A CN116322741 A CN 116322741A CN 202180056599 A CN202180056599 A CN 202180056599A CN 116322741 A CN116322741 A CN 116322741A
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China
Prior art keywords
thr
ham
asn
artificial sequence
gly
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CN202180056599.9A
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English (en)
Chinese (zh)
Inventor
J·C·F·尼尔森
K·T·G·里格波尔特
E·M·贝克
M·伦德
P·马高迪
B·巴拉林-冈萨雷斯
S·L·佩德森
N·弗朗
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Gubra ApS
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Gubra ApS
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=72659001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN116322741(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gubra ApS filed Critical Gubra ApS
Publication of CN116322741A publication Critical patent/CN116322741A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202180056599.9A 2020-09-24 2021-09-23 具有改善的胰淀素受体(hAMY3R)效力的hAM15-52类似物 Pending CN116322741A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20198117 2020-09-24
EP20198117.2 2020-09-24
PCT/EP2021/076250 WO2022063925A1 (en) 2020-09-24 2021-09-23 Ham15-52 analogues with improved amylin receptor (hamy3r) potency

Publications (1)

Publication Number Publication Date
CN116322741A true CN116322741A (zh) 2023-06-23

Family

ID=72659001

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180056599.9A Pending CN116322741A (zh) 2020-09-24 2021-09-23 具有改善的胰淀素受体(hAMY3R)效力的hAM15-52类似物

Country Status (21)

Country Link
US (2) US12139520B2 (https=)
EP (1) EP4021929B1 (https=)
JP (1) JP2023544959A (https=)
KR (1) KR20230073176A (https=)
CN (1) CN116322741A (https=)
AU (1) AU2021350396A1 (https=)
BR (1) BR112023002525A2 (https=)
CA (1) CA3189267A1 (https=)
DK (1) DK4021929T5 (https=)
ES (1) ES2950137T3 (https=)
FI (1) FI4021929T3 (https=)
HR (1) HRP20230534T1 (https=)
HU (1) HUE062560T2 (https=)
IL (1) IL300620B2 (https=)
MX (1) MX2023002182A (https=)
PL (1) PL4021929T3 (https=)
PT (1) PT4021929T (https=)
RS (1) RS64256B1 (https=)
SI (1) SI4021929T1 (https=)
WO (1) WO2022063925A1 (https=)
ZA (1) ZA202301635B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI815327B (zh) 2021-03-03 2023-09-11 美商美國禮來大藥廠 長效澱粉素受體促效劑及其用途
IL317600B2 (en) 2022-07-01 2026-03-01 Gubra As Amylin receptor (HAMY3R) agonists with improved chemical stability
TW202540155A (zh) 2023-11-30 2025-10-16 丹麥商諾佛 儂迪克股份有限公司 Glp-1、gip及澱粉素受體之三重促效劑

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007022123A2 (en) * 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
WO2015040182A2 (en) * 2013-09-19 2015-03-26 Zealand Pharma A/S Amylin analogues
US20200115430A1 (en) * 2018-10-11 2020-04-16 Intarcia Therapeutics, Inc. Human amylin analog polypeptides and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
GB9912350D0 (en) * 1999-05-26 1999-07-28 European Molecular Biology Lab Embl Modified cytokine
FI117667B (fi) * 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
NZ579621A (en) * 2004-02-11 2011-03-31 Amylin Pharmaceuticals Inc Hybrid polypeptides with selectable properties
AU2012212047A1 (en) * 2011-02-03 2013-08-22 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
JP6121992B2 (ja) 2011-06-10 2017-04-26 ノヴォ ノルディスク アー／エス ポリペプチド
BR112017019378A2 (pt) 2015-03-18 2019-02-19 Zealand Pharma A/S análogos de amilina
WO2019005623A1 (en) 2017-06-30 2019-01-03 Adepthera Llc PEPTIDE ANALOGS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007022123A2 (en) * 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
WO2015040182A2 (en) * 2013-09-19 2015-03-26 Zealand Pharma A/S Amylin analogues
US20200115430A1 (en) * 2018-10-11 2020-04-16 Intarcia Therapeutics, Inc. Human amylin analog polypeptides and methods of use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DALBOEGE LOUISE S., MAGOTTI PAOLA, BUCH-MÅNSON NINA, BECH ESBEN M., FINK LISBETH N., PEDERSEN SØREN LJUNGBERG, FOSGERAU KELD: "2037-P: Characterization of Novel Unimolecular Amylin-Adrenomedullin Dual Agonists", DIABETES, AMERICAN DIABETES ASSOCIATION :, vol. 68, no. Supplement 1, 4 June 2019 (2019-06-04), pages 2037 - P, XP055863394, ISSN: 0012-1797, DOI: 10.2337/db19-2037-P *
JAN-PATRICK FISCHER等: "The Impact of Adrenomedullin Thr22 on Selectivity within the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein System", CHEMMEDCHEM, vol. 13, pages 1797 - 1805, XP055777098, DOI: 10.1002/cmdc.201800329 *
S. D. ROBINSON等: "Novel peptide antagonists of adrenomedullin and calcitonin gene-realted peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3", J. PHARMACOL. EXP. THER., vol. 339, no. 1, pages 321 *

Also Published As

Publication number Publication date
CA3189267A1 (en) 2022-03-31
AU2021350396A1 (en) 2023-03-16
IL300620B2 (en) 2025-12-01
IL300620A (en) 2023-04-01
JP2023544959A (ja) 2023-10-26
ZA202301635B (en) 2024-03-27
HRP20230534T1 (hr) 2023-08-04
BR112023002525A2 (pt) 2023-04-04
WO2022063925A1 (en) 2022-03-31
KR20230073176A (ko) 2023-05-25
HUE062560T2 (hu) 2023-11-28
RS64256B1 (sr) 2023-07-31
IL300620B1 (en) 2025-08-01
US20240101634A1 (en) 2024-03-28
PL4021929T3 (pl) 2023-07-31
FI4021929T3 (fi) 2023-06-14
PT4021929T (pt) 2023-06-21
SI4021929T1 (sl) 2023-09-29
ES2950137T3 (es) 2023-10-05
DK4021929T5 (da) 2024-07-29
MX2023002182A (es) 2023-11-16
DK4021929T3 (da) 2023-07-10
US12139520B2 (en) 2024-11-12
EP4021929B1 (en) 2023-04-26
US20250129134A1 (en) 2025-04-24
EP4021929A1 (en) 2022-07-06

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