CN116270382A - Scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching - Google Patents
Scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching Download PDFInfo
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- CN116270382A CN116270382A CN202310143452.4A CN202310143452A CN116270382A CN 116270382 A CN116270382 A CN 116270382A CN 202310143452 A CN202310143452 A CN 202310143452A CN 116270382 A CN116270382 A CN 116270382A
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- scalp care
- root extract
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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Abstract
The invention belongs to the technical field of washing and caring products, and particularly relates to a scalp care composition with effects of preventing desquamation, controlling oil and relieving itching, and a preparation method and application thereof. The composition comprises the following components: the natural plant extract composition comprises ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract. The composition has the advantages that the moisture retention, the repair function and the inhibition on inflammatory factors of the scalp are improved obviously by the synergistic effect of the components, and the irritation of the shampoo to the scalp can be reduced obviously when the composition is applied to the shampoo. Therefore, the scalp care composition has the composite effects of preventing desquamation, controlling oil and relieving itching, and the preparation method is simple and easy to industrialize.
Description
Technical Field
The invention belongs to the technical field of washing and caring products, and particularly relates to a scalp care composition with effects of preventing desquamation, controlling oil and relieving itching, and a preparation method and application thereof.
Background
The hair has the effects of defending, protecting, increasing information communication and improving the appearance. Hair is produced by hair follicles, a structurally complex skin accessory, which continuously undergo periodic and cyclic growth in anagen, catagen and telogen phases. Once the follicular cycle is deregulated, it will affect the normal growth of the hair follicle and thus lead to the occurrence of alopecia. In addition, whether the scalp is healthy is closely related to the health of hair follicles and hair attached thereto. However, the scalp is exposed to the environment every day, and many potential factors such as ultraviolet rays, air pollutants and the like may cause damage to the skin barrier by damaging the horny layer, and cause irritation of the scalp to cause inflammation reactions or cell damage such as redness, itching, stinging and the like.
The most common pathological alopecia is seborrheic alopecia, also called androgenic alopecia, which accounts for more than 95% of the occurrence rate of the pathological alopecia, and is usually accompanied by the problem of excessive secretion of scalp grease. In recent years, as social competition increases, survival pressure increases, high fat diet, sleep decreases, environmental impact, hair dyeing, hair waving and other hair styling products are used, and hair loss patients show signs of rejuvenation, so that young and middle-aged people become the dominant force of hair loss. The existing scalp care products for cleaning the scalp generally contain a large amount of components such as surfactant, essence, preservative and the like, so that the damage of scalp barriers is increased.
Hair loss, which appears to be intact and elegant, often places an inconceivable mental and psychological burden on the patient. Such baldness individuals often have a very strong desire to care or treat. Therefore, hair loss preventing and hair growing medicines and scalp care washing and caring products are attracting attention. At present, various hair growth shampoos and traditional Chinese medicine health products are mainly used as common hair growth agents in the market of China. The common hair-growing shampoo in the market mainly reduces seborrheic alopecia through the effect of removing scalp grease, but obviously has the problems of poor effect, temporary treatment and temporary treatment, and the hair-growing traditional Chinese medicine health care product mainly achieves the effect of promoting hair growth through improving microcirculation, but also has the problems of poor effect, relatively troublesome use and the like. Therefore, there is a great market demand for scalp care products (especially shampoos) with strong anti-desquamation, oil control and itching relieving composite functions, good use experience for consumers and convenient use.
In view of the urgent need for hair care and hair growth effects and multiple functions such as good use experience for consumers, there is a great need to develop a scalp care composition which has multiple functions such as hair loss prevention, dandruff removal, oil control, itching relief and the like and has good use experience for consumers.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a scalp care composition with the effects of preventing desquamation, controlling oil and relieving itching, and a preparation method and application thereof.
Specifically, the invention is realized through the following technical schemes:
in a first aspect, the present invention provides a scalp care composition having anti-desquamation, oil control and antipruritic effects, the composition comprising, in parts by weight: 0.5-20 parts of natural plant extract composition, 0.5-10 parts of natural amino acid, 0.5-3 parts of hydroxyapatite, 0.5-3 parts of allantoin, 0.5-3 parts of thioglycopeptide and 0.5-20 parts of water.
Alternatively, in the above scalp care composition, the composition comprises the following components in parts by weight: 5-15 parts of natural plant extract composition, 1-8 parts of natural amino acid, 1-2 parts of hydroxyapatite, 1-2 parts of allantoin, 1-2 parts of thioglycopeptide and 10-20 parts of water.
Alternatively, in the above scalp care composition, the composition comprises the following components in parts by weight: 12 parts of natural plant extract composition, 6 parts of natural amino acid, 1 part of hydroxyapatite, 2 parts of allantoin, 1 part of thioglycopeptide and 18 parts of water.
Alternatively, in the above scalp care composition, the composition is made of a natural plant extract composition, natural amino acids, hydroxyapatite, allantoin, thioglycopeptides, and water.
Alternatively, in the above scalp care composition, the natural plant extract composition comprises one or more of the following: ginger (ZINGIBER OFFICINALE) root extract, angelica (ANGELICA POLYMORPHA SINENSIS) root extract, BIOTA ORIENTALIS (BIOTA ORIENTALIS) leaf extract, polygonum multiflorum (POLYGONUM MULTIFLORUM) root extract, notoginseng (PANAX NOTOGINSENG) root extract and lithospermum (LITHOSPERMUM ERYTHRORHIZON) root extract.
Alternatively, in the above scalp care composition, the natural plant extract composition comprises: ginger root extract, angelica root extract, biota orientalis leaf extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract.
Alternatively, in the above scalp care composition, the natural plant extract composition is made of the following components: ginger root extract, angelica root extract, biota orientalis leaf extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract.
Preferably, the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1.
alternatively, in the above scalp care composition, the natural amino acid comprises one or more of the following: glycine, alanine, serine, valine, proline, threonine, isoleucine, phenylalanine, histidine, arginine or aspartic acid.
Preferably, the natural amino acid is made of the following components: glycine, serine, valine and arginine.
More preferably, glycine, in weight proportions: serine: valine: arginine is 2:2:1:1.
alternatively, in the scalp care composition, the thio glycopeptide is a glycopeptide substance, and the thio glycopeptide is obtained by sulfonation of a glycopeptide extracted from the duodenum or gastric mucosa of a pig.
Preferably, the thioglycopeptide has a CAS number of 54182-59-1, which is commercially available.
Alternatively, in the above scalp care composition, the hydroxyapatite is a hydroxyapatite micropowder.
Preferably, the hydroxyapatite micropowder has an average particle size of 1 to 8 μm, more preferably 3 to 6 μm, most preferably 3.5 μm.
In a second aspect, the present invention provides a method of preparing the scalp care composition of the first aspect described above, comprising the steps of: and uniformly mixing the components to obtain the scalp care composition.
Preferably, the preparation method comprises the following steps: mixing natural plant extract composition and hydroxyapatite at room temperature, adding half amount of water, stirring while adding water, heating to 50deg.C, stopping heating, maintaining the temperature, and stirring until mixing is uniform. The mixture was cooled to room temperature under stirring, and then natural amino acids, allantoin and thioglycopeptides and the remaining water were added, and gentle stirring was continued at room temperature for 10 minutes, to obtain the scalp care composition.
In a third aspect, the present invention provides the use of a scalp care composition as described in the first aspect above in the manufacture of a scalp care shampoo.
Alternatively, in the above use, the scalp care shampoo is selected from the group consisting of: shampoo, conditioner, essence, hair mask or scalp care solution.
Preferably, the scalp care shampoo or shampoo is used.
Alternatively, in the above use, the scalp care shampoo contains from 8% to 20% by weight of the scalp care composition of the first aspect.
Preferably, the scalp care shampoo contains from 8% to 15% by weight of the scalp care composition of the first aspect.
More preferably, the scalp care shampoo contains from 8% to 10% by weight of the scalp care composition of the first aspect.
In a fourth aspect, as a representative example, the present invention provides a shampoo comprising, in weight percent, from 8% to 15% of the scalp care composition of the first aspect described above.
Preferably, the shampoo comprises 10% by weight of the scalp care composition of the first aspect described above.
It is understood that within the scope of the present invention, the above-described technical features of the present invention and technical features specifically described below (e.g., in the examples) may be combined with each other to constitute new or preferred technical solutions. Is limited to a space and will not be described in detail herein.
Compared with the prior art, the invention has the following beneficial effects:
(1) The scalp care composition provided by the invention has the advantages that the moisture retention, the repair function and the inhibition on inflammatory factors of the scalp are all obviously improved through the synergistic effect of the components, and the irritation of the shampoo to the scalp can be obviously reduced when the scalp care composition is applied to the shampoo.
(2) The scalp care composition has the composite effects of preventing desquamation, controlling oil and relieving itching, and has good use experience for consumers.
(3) The scalp care composition has wide sources of raw materials, can be purchased and obtained, adopts active ingredients of natural sources, has high safety, no irritation, simple preparation method and easy industrialization.
Detailed Description
For the convenience of understanding of those skilled in the art, various major active ingredients involved in the present invention are described below.
The Hydroxyapatite (HAP) is a main component of human bones and teeth, has good biocompatibility, no toxicity, no irritation, no human rejection reaction, no aging sensitization and cancerogenesis, can be chemically combined with bone tissues, and has been widely used as bone substitute materials, plastic and cosmetic surgical materials, dental materials, chromatographic purification materials, calcium supplements, hemostatic materials and the like at present. However, there is no report in the prior art that a superfine hydroxyapatite powder having a specific particle size range is used for scalp care.
The allantoin is a substance for softening the skin cuticle, is beneficial to the shedding of dead skin cells, helps the skin to keep more moisture, and makes the skin smooth; allantoin easily reaches deep skin, and promotes fibroblasts to produce more collagen, elastin and mucopolysaccharide, thereby effectively reducing and preventing the formation of wrinkles. Allantoin can inhibit the production of 1L-1 alpha, and has tranquilizing, astringent and antiinflammatory effects. Allantoin can reduce adhesion of keratinocytes and accelerate epidermal cell regeneration.
"Sulfur glycopeptide" sulfur glycopeptide is a sulfate polyester obtained by sulfating the extractive glycopeptide of pig duodenum, is a semisynthetic glycopeptide polysulfate, and belongs to mucopolysaccharide. Has various biological activities of mucopolysaccharide, such as anti-tumor, antiviral, anti-atherosclerosis, anti-inflammatory, and blood lipid reducing. The thioglycopeptides have a CAS number of 54182-59-1, which are commercially available.
The ginger (ZINGIBER OFFICINALE) root extract has the main functions of an antioxidant, an anti-inflammatory agent and a skin conditioner in the skin care product, is safe and can be used safely without influence on pregnant women. The ginger root extract has a certain inhibition effect on dermatophytes, streptococci albicans and oral cavity bacteria, but has poor inhibition effect on common mould and the like; can enhance skin activity, activate skin, and has antioxidant and antiaging effects; can also promote hair growth, and can be used as hair promoter; it also has effects in keeping moisture and inhibiting odor.
The angelica (ANGELICA POLYMORPHA SINENSIS) root extract has the main functions of an antioxidant and a skin conditioner in cosmetics and skin care products, is safe and can be used safely, and has no influence on pregnant women. Based on the effects of Chinese angelica on promoting blood circulation by removing blood stasis and improving skin microcirculation, the Chinese angelica can be used for a plurality of cosmetics for promoting blood circulation, such as hair growth, regulating skin secretion, supplementing nutrition, resolving dark circles and the like; proliferation of angelica to vascular endothelial cells shows that the angelica has the effect of solidifying capillary vessels while activating blood; the angelica sinensis has good SOD-like activity, inhibits membrane lipid peroxidation and free radical reaction caused by superoxide radicals, antagonizes damage of the free radicals to tissues by combining with various mechanisms such as biological membrane phospholipid for protecting membrane lipid, and has special effects on dark complexion or sore swelling caused by free radical retardation; has an anti-aging effect on the activation rate of the fluorescent enzyme and the proliferation effect on stem cells.
The extract of the arborvitae (BIOTA ORIENTALIS) leaves has the main functions of preventing alopecia and nourishing hair in cosmetics and skin care products, is safe and can be used with ease, and has no influence on pregnant women. The cacumen Platycladi extract is a pure natural plant extract product derived from cacumen Platycladi, and can smooth scalp to make nutrient components better absorbed by hair roots, stimulate and care hair stems, prevent falling off, promote hair growth, and achieve hair loss preventing and hair growth promoting effects.
The polygonum multiflorum (POLYGONUM MULTIFLORUM) root extract has the main functions of an antibacterial agent, an antioxidant and a humectant in cosmetics and skin care products, is safe and can be used safely, and has no influence on pregnant women generally. The Polygonum multiflorum root extract is extract of dry root tuber of Polygonum multiflorum of Polygonaceae, and its main functional components are lecithin (good moisturizing effect), emodin, rhein and other components. Polygonum multiflorum has been widely used as a cosmetic by oral or topical administration because of its ability to blacken hair.
The Notoginseng radix (PANAX NOTOGINSENG) root extract has the main functions of anti-inflammatory agent, antioxidant and antibacterial agent in cosmetics and skin care products. Notoginseng radix extract has effects of inhibiting edema and nuclear factor receptor activation, which is an index reflecting antiinflammatory ability, and can be used as antiinflammatory agent; the pseudo-ginseng extract can eliminate oxygen free radicals, enhance the activity of endogenous superoxide dismutase, strengthen the scavenging capacity of an organism on the oxygen free radicals, lighten the chain reaction caused by the oxygen free radicals and reduce the peroxidation of lipid in blood; the Notoginseng radix extract has antibacterial effect, and Notoginseng radix total saponin has strong inhibiting effect on certain fungi, and has certain inhibiting effect on Staphylococcus aureus and Escherichia coli.
The radix arnebiae (LITHOSPERMUM ERYTHRORHIZON) root extract has the main functions of antioxidation and anti-aging in cosmetics and skin care products, is safe and can be used safely, and has no influence on pregnant women. The radix Arnebiae extract has effect in promoting cathepsin activity, and has antifungal and antiviral effects. It has effects of enhancing metabolism of skin cells, and resisting aging in combination with its antioxidant effect.
The above-mentioned natural plant extracts and other raw materials of natural origin used in the scalp care composition having the effects of preventing desquamation, controlling oil and relieving itching of the present invention are all commercially available cosmetic raw materials which can be obtained by purchase.
The invention will be further illustrated with reference to specific examples. It should be understood that the detailed description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products. Preparation examples:
example 1:
scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching is prepared from the following components in parts by weight: 12 parts of a natural plant extract composition, 6 parts of natural amino acid, 1 part of hydroxyapatite, 2 parts of allantoin, 1 part of thioglycopeptide and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1, a step of; the natural amino acid is prepared from the following components: glycine, serine, valine and arginine, glycine in weight proportions: serine: valine: arginine is 2:2:1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 3.5 mu m,
the preparation method comprises the following steps: mixing natural plant extract composition and hydroxyapatite at room temperature, adding half amount of water, stirring while adding water, heating to 50deg.C, stopping heating, maintaining the temperature, and stirring until mixing is uniform. The mixture was cooled to room temperature under stirring, and then natural amino acids, allantoin and thioglycopeptides and the remaining water were added, and gentle stirring was continued at room temperature for 10 minutes, to obtain the scalp care composition.
Example 2:
scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching is prepared from the following components in parts by weight: 10 parts of a natural plant extract composition, 8 parts of natural amino acid, 2 parts of hydroxyapatite, 1 part of allantoin, 1 part of thioglycopeptide and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1, a step of; the natural amino acid is prepared from the following components: glycine, serine, valine and arginine, glycine in weight proportions: serine: valine: arginine is 2:2:1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 4 mu m,
the preparation method is the same as in example 1.
Example 3:
scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching is prepared from the following components in parts by weight: 8 parts of a natural plant extract composition, 8 parts of natural amino acid, 2 parts of hydroxyapatite, 2 parts of allantoin, 2 parts of thioglycopeptide and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1, a step of; the natural amino acid is prepared from the following components: glycine, serine, valine and arginine, glycine in weight proportions: serine: valine: arginine is 2:2:1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 3 mu m,
the preparation method is the same as in example 1.
Comparative example 1:
a scalp care composition, which is prepared from the following components in parts by weight: 12 parts of a natural plant extract composition, 6 parts of natural amino acid, 1 part of hydroxyapatite, 2 parts of allantoin, 1 part of thioglycopeptide and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract and polygonum multiflorum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: the polygonum multiflorum root extract is 2:2:1:1, a step of; the natural amino acid is prepared from the following components: glycine, serine, valine and arginine, glycine in weight proportions: serine: valine: arginine is 2:2:1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 3.5 mu m,
the preparation method is the same as in example 1.
Comparative example 2:
scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching is prepared from the following components in parts by weight: 12 parts of a natural plant extract composition, 6 parts of natural amino acid, 1 part of hydroxyapatite, 2 parts of allantoin, 1 part of thioglycopeptide and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1, a step of; the natural amino acid is prepared from the following components: glycine and serine, glycine in weight ratio: serine is 1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 3.5 mu m,
the preparation method is the same as in example 1.
Comparative example 3:
scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching is prepared from the following components in parts by weight: 12 parts of a natural plant extract composition, 6 parts of natural amino acid, 1 part of hydroxyapatite, 3 parts of allantoin and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1, a step of; the natural amino acid is prepared from the following components: glycine, serine, valine and arginine, glycine in weight proportions: serine: valine: arginine is 2:2:1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 3.5 mu m,
the preparation method is the same as in example 1.
Comparative example 4:
scalp care composition with effects of preventing alopecia, removing dandruff, controlling oil and relieving itching is prepared from the following components in parts by weight: 12 parts of a natural plant extract composition, 6 parts of natural amino acid, 1 part of hydroxyapatite, 2 parts of allantoin, 1 part of thioglycopeptide and 18 parts of water; the natural plant extract composition is prepared from the following components: ginger root extract, angelica root extract, biota orientalis extract, polygonum multiflorum root extract, pseudo-ginseng root extract and lithospermum root extract, wherein the ginger root extract is prepared from the following components in percentage by weight: angelica sinensis root extract: extract of biota orientalis: polygonum multiflorum root extract: notoginseng radix root extract: the radix Arnebiae extract is 1:1:1:1:1:1, a step of; the natural amino acid is prepared from the following components: glycine, serine, valine and arginine, glycine in weight proportions: serine: valine: arginine is 2:2:1:1, the hydroxyapatite is superfine hydroxyapatite powder, the average grain diameter of the superfine hydroxyapatite powder is 350nm,
the preparation method is the same as in example 1.
Effect examples:
effect example 1: foam experience and in-use comfort sensory feel for shampoos containing the scalp care compositions of the present invention
Evaluation test
The compositions of examples 1-3 and comparative examples 1-4 were made into 10% by weight shampoo using a conventional shampoo base. With the same hair quality population as experimental subjects, 20 persons in each group, after each group of subjects used the shampoo prepared in examples 1 to 3 and comparative examples 1 to 4 described above and the blank shampoo base, sensory evaluation of foam experience was performed based on foaming power and foam texture, and sensory evaluation was performed based on use comfort.
Specifically, the score of the sensory evaluation mode is 1-5, wherein 1 score represents easy broken and loose foam with weak foaming power, and 5 score represents soft, dense and strong foaming power foam, and the higher the score, the better the experience of the foam of the subject. For the evaluation of the comfort level of the shampoo, the score is also 1-5, wherein the score of 1 represents obvious irritation, and the score of 5 represents no irritation when the shampoo is used, wherein the larger the score is, the higher the comfort level of the shampoo is. The scores of each group of subjects were counted after scoring, and the average value of the scores of each group was counted, and the results are shown in table 1 below.
Table 1: foam experience and in-use comfort sensory evaluation results for shampoos containing the scalp care compositions of the present invention
| Group of | Foam sensory experience average score | Comfort level in use |
| Example 1 | 4.9 | 4.9 |
| Example 2 | 4.9 | 4.8 |
| Example 3 | 4.9 | 4.9 |
| Comparative example 1 | 4.8 | 4.8 |
| Comparative example 2 | 3.5 | 4.4 |
| Comparative example 3 | 3.2 | 4.1 |
| Comparative example 4 | 4.7 | 4.8 |
| Blank matrix | 3.1 | 3.5 |
As shown in table 1, the experimental results demonstrate that the blank matrix is relatively poor in both the foam sensory experience and the use comfort. The shampoos containing examples 1-3 were better experienced at both foaming and foam feel than comparative examples 1-4 and the blank matrix. From the experimental results of the shampoo containing comparative examples 1 to 4, it can be seen that the variation in the kind of natural plant extract in the composition and the variation in the particle size of hydroxyapatite have less influence on the foaming experience and the use comfort of the shampoo. However, whether or not the composition contains a glycopeptide or not and the kind of amino acid contained therein have a great influence on the foam experience and the comfort of use. It can be seen that the shampoo comprising the scalp care composition of the present invention significantly improves the foam performance of the shampoo by comprising the sulfur glycopeptide and the amino acid having a specific composition and dosage ratio, can effectively achieve thickening and generate foam having excellent characteristics, and at the same time the shampoo comprising the scalp care composition of the present invention has no irritation and is highly comfortable to use.
Effect example 2: oil control anti-dandruff and hair care and hair growth effect test for shampoo containing scalp care composition
Test on test
The compositions of example 1 and comparative examples 1-4 were made into 10% by weight shampoo using a conventional shampoo base. 120 volunteers with abundant dandruff and oily hair quality were randomly selected and aged between 25-60 years. Volunteers have no disease causing a large amount of alopecia, only the scalp is easy to itch and oil, the amount of alopecia is more than 100 per day on average, and the alopecia lasts for more than 2 months. The volunteers were randomly divided into 6 groups of 20 persons each, and hair oiliness and dandruff effects were observed in the morning after 30 days of continuous shampooing once a day in the morning using the shampoo and blank shampoo bases prepared in the above examples 1 and comparative examples 1 to 4, respectively.
The tester uses a grease tester, namely a Sebumeter SM815 to test the grease content of the scalp respectively, records the data as D0, adopts the product to shampoo once a day, tests the grease content on the 20 th day and the 30 th day, and records the data;
oil content change Rate (%) = { (oil content after use of product-oil content before use of product)/oil content before use of product } ×100%
In addition, at the end of the study, volunteers were observed and counted for hair volume, hair density.
Table 2: results of oil control test for shampoos containing the scalp care compositions of the present invention
| Group of | 20-day oil change Rate (%) | 30-day oil change Rate (%) |
| Example 1 | -23.4 | -34.2 |
| Comparative example 1 | -21.5 | -33.8 |
| Comparative example 2 | -22.9 | -34.3 |
| Comparative example 3 | -23.5 | -33.9 |
| Comparative example 4 | -18.7 | -28.5 |
| Blank matrix | -6.1 | -6.7 |
As shown in table 2, the experimental results indicate that the substance that mainly plays a role in controlling oil in the shampoo containing the scalp care composition of the present invention is the hydroxyapatite micropowder. However, when the results of the group of example 1 and the group of comparative example 4 were compared, it was found that the lower the particle size of the ultra-fine hydroxyapatite powder was, the better the oil control effect was, but the less the oil control effect was, than the micro-scale.
In addition, during the experiment, the anti-dandruff effect of the shampoo containing the scalp care composition of the invention is observed at the same time, and as a result, the shampoo containing the scalp care composition of the invention is found to have better oil control and anti-dandruff effect in the example 1 group, the total anti-dandruff effective rate can reach more than 98%, and the anti-dandruff effect in the comparative examples 1-4 groups is reduced to different degrees, wherein the variety change of the natural plant extract and the thioglycopeptides have great influence on the anti-dandruff effect, and the shampoo containing the scalp care composition of the invention has good oil control and anti-dandruff effect.
Table 3: hair care and hair growth test results for shampoos containing the scalp care compositions of the present invention
As shown in Table 3, the results of the experiment show that the shampoo comprising the scalp care composition of the present invention (example 1 group) has the best effect of hair care and hair growth, and the proportion of hair loss and regrowth in the area of hair loss of the volunteer group is significantly reduced up to 97% and 93%, respectively. As can also be seen from the above experimental results, both the natural plant extract species and the thioglycopeptides in the scalp care composition of the present invention have a significant effect on hair care and hair growth, and when the species of the natural plant extract in the composition is changed and the thioglycopeptides component is deleted from the composition, the hair care and hair growth of the composition is significantly reduced (see experimental results of comparative example 1 and comparative example 3, respectively). It can be seen that the natural plant extracts and thioglycopeptides in the composition of the present invention have a synergistic effect in hair care and hair growth.
Effect example 3: effect of the scalp care compositions of the present invention on the condition of mouse hair growth
Male C57BL/6J mice of 6-8 weeks of age were randomly grouped into 4 groups of 10 mice each. Group 1 is a blank control group using only water, and groups 2 to 4 use the compositions prepared in example 1 and comparative examples 1 and 3, respectively. Each group was given to the test object after shaving (3×3 cm) on the backs of the mice for 24 hours, 1 time/day, and the test object was given continuously for 21 days, and after the end of the experiment, the experimental animals were euthanized, the newly grown hair length was measured and the test area was counted for hair follicles. Statistical data are expressed as mean ± standard error. Statistical analysis was performed using repeated-assay analysis of variance and the differences between groups were compared using Fisher LSD test. Experimental data are shown in table 4 below.
Table 4: effect of the scalp care compositions of the present invention on the Hair growth Length and the number of hair follicles in mice (average.+ -. SE)
| Group of | Hair length (mm) | Number of hair follicles (number) |
| Blank control group | 8.22±0.19 | 78±2.46 |
| Example 1 group | 12.05±0.37 **，# | 118±3.94 **，# |
| Comparative example 1 group | 10.23±0.39 * | 102±3.15 * |
| Comparative example 3 group | 9.15±0.25 | 89±2.73 |
Note that: * P <0.05, p <0.01, compared to the blank group; # p <0.05, compared to comparative example 3 group.
As can be seen from the experimental data in table 4, the compositions of example 1 and the compositions of comparative example 1 and comparative example 3 each were able to increase the hair growth length and the number of hair follicles in mice to varying degrees. Wherein the hair length and hair follicle count of the mice of example 1 group (p < 0.01) and comparative example 1 group (p < 0.05) were significantly higher than the placebo group. In addition, the hair length and number of hair follicles were also significantly higher in the mice of example 1 than in the mice of comparative example 3 (p < 0.05).
Consistent with the hair growth and hair care results in effect example 2, it can also be seen from the above experimental results that both the nature of the plant extract and the thioglycopeptides in the scalp care composition of the present invention have a significant effect on hair care and hair growth, and that the effects of the composition in promoting hair growth and increasing hair follicle effect are significantly reduced when the nature of the plant extract in the composition is changed and the thioglycopeptides component is deleted from the composition. In contrast, whether or not a thioglycopeptide is included in the composition has a greater impact on the above-described effects of the composition.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. A scalp care composition with the effects of preventing alopecia, removing dandruff, controlling oil and relieving itching, which is characterized in that: the composition comprises the following components in parts by weight: 0.5-20 parts of natural plant extract composition, 0.5-10 parts of natural amino acid, 0.5-3 parts of hydroxyapatite, 0.5-3 parts of allantoin, 0.5-3 parts of thioglycopeptide and 0.5-20 parts of water.
2. A scalp care composition according to claim 1 characterized in that: the composition comprises the following components in parts by weight: 5-15 parts of natural plant extract composition, 1-8 parts of natural amino acid, 1-2 parts of hydroxyapatite, 1-2 parts of allantoin, 1-2 parts of thioglycopeptide and 10-20 parts of water.
3. A scalp care composition according to claim 1 or claim 2, characterized in that: the natural plant extract composition comprises one or more of the following: ginger (ZINGIBER OFFICINALE) root extract, angelica (ANGELICA POLYMORPHA SINENSIS) root extract, BIOTA ORIENTALIS (BIOTA ORIENTALIS) leaf extract, polygonum multiflorum (POLYGONUM MULTIFLORUM) root extract, notoginseng (PANAX NOTOGINSENG) root extract and lithospermum (LITHOSPERMUM ERYTHRORHIZON) root extract.
4. A scalp care composition according to any one of claims 1 to 3 characterized in that: the natural amino acids comprise one or more of the following: glycine, alanine, serine, valine, proline, threonine, isoleucine, phenylalanine, histidine, arginine or aspartic acid; the thio glycopeptides are glycopeptides, and are obtained by extracting glycopeptides from the duodenum or gastric mucosa of pigs and performing sulfonation treatment.
5. A scalp care composition according to any one of claims 1 to 4 characterized in that: the hydroxyapatite is a superfine hydroxyapatite powder, preferably, the superfine hydroxyapatite powder has an average particle diameter of 1-8 μm, more preferably, the average particle diameter is 3-6 μm.
6. A method of preparing a scalp care composition according to any one of claims 1 to 5 characterized in that: the method comprises the following steps: and uniformly mixing the components to obtain the scalp care composition.
7. Use of a scalp care composition as claimed in any one of claims 1 to 5 in the manufacture of a scalp care shampoo.
8. Use according to claim 7, characterized in that: the scalp care cleansing article is selected from the group consisting of: shampoo, conditioner, essence, hair mask or scalp care solution.
9. Use according to claim 7 or claim 8, characterized in that: the scalp care shampoo comprising from 8% to 20% by weight of the scalp care composition of any one of claims 1 to 5.
10. A shampoo, characterized in that: the shampoo comprising, in weight percent, from 8% to 15% of the scalp care composition of any one of claims 1 to 5.
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