CN116270322A - Mosquito repellent product containing menthanediol and preparation and application methods thereof - Google Patents
Mosquito repellent product containing menthanediol and preparation and application methods thereof Download PDFInfo
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- CN116270322A CN116270322A CN202310274819.6A CN202310274819A CN116270322A CN 116270322 A CN116270322 A CN 116270322A CN 202310274819 A CN202310274819 A CN 202310274819A CN 116270322 A CN116270322 A CN 116270322A
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- menthanediol
- mosquito repellent
- repellent product
- alcohol
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- 239000000077 insect repellent Substances 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 claims abstract description 14
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 9
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 9
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 239000003906 humectant Substances 0.000 claims abstract description 9
- 239000003381 stabilizer Substances 0.000 claims abstract description 9
- 239000004094 surface-active agent Substances 0.000 claims abstract description 9
- -1 menthane diol Chemical class 0.000 claims abstract description 8
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 7
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 7
- 244000166675 Cymbopogon nardus Species 0.000 claims abstract description 7
- 235000018791 Cymbopogon nardus Nutrition 0.000 claims abstract description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 7
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 7
- 229940036350 bisabolol Drugs 0.000 claims abstract description 7
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940041616 menthol Drugs 0.000 claims abstract description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 7
- 239000000341 volatile oil Substances 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 6
- 239000000796 flavoring agent Substances 0.000 claims abstract description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 6
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims abstract description 5
- 239000004359 castor oil Substances 0.000 claims abstract description 5
- 235000019438 castor oil Nutrition 0.000 claims abstract description 5
- 229940073499 decyl glucoside Drugs 0.000 claims abstract description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 5
- 239000010642 eucalyptus oil Substances 0.000 claims abstract description 4
- 229940044949 eucalyptus oil Drugs 0.000 claims abstract description 4
- 239000003755 preservative agent Substances 0.000 claims abstract description 4
- 230000002335 preservative effect Effects 0.000 claims abstract description 4
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 3
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 244000165852 Eucalyptus citriodora Species 0.000 claims description 4
- 235000004722 Eucalyptus citriodora Nutrition 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical group CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical group OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 3
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 102100035784 Decorin Human genes 0.000 claims description 2
- 108090000738 Decorin Proteins 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract description 2
- 239000005871 repellent Substances 0.000 description 18
- 230000002940 repellent Effects 0.000 description 18
- 241000255925 Diptera Species 0.000 description 12
- 241000282414 Homo sapiens Species 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 5
- 229960001673 diethyltoluamide Drugs 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 4
- 239000000575 pesticide Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000361 pesticidal effect Effects 0.000 description 3
- 241000256173 Aedes albopictus Species 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 241000256118 Aedes aegypti Species 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241000256059 Culex pipiens Species 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 208000003152 Yellow Fever Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000152 carbamate pesticide Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 230000032669 eclosion Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of mosquito repellents, and discloses a mosquito repellent product containing menthanediol, which comprises the following components in percentage by mass: 3.0 to 15.0 percent of menthane diol, 8.0 to 12.0 percent of 95 percent alcohol, 0.1 to 0.6 percent of emulsifying agent, 0.1 to 0.8 percent of humectant, 0.1 to 1.0 percent of preservative, 1.0 to 5.0 percent of surfactant, 0.1 to 0.6 percent of stabilizer, 1.0 to 5.0 percent of flavoring agent decanol, 0.001 to 0.005 percent of antioxidant, 0.1 to 1.0 percent of bisabolol, 0.2 to 1.5 percent of salicylic acid, 0.001 to 0.005 percent of menthol, 0.1 to 1.0 percent of citronella essential oil, 0.1 to 3.0 percent of eucalyptus oil of lemon and 70 to 80 percent of deionized water. The mosquito repellent containing the menthanediol is a water-based milky white product, contains 10% of the menthanediol, has remarkable mosquito repellent effect, solubilizes the menthanediol by the joint coordination of hydrogenated castor oil, decyl glucoside, octyl glycol and alcohol, greatly reduces the alcohol content and improves the safety.
Description
Technical Field
The invention relates to the technical field of mosquito repellents, in particular to a mosquito repellent product containing menthanediol and a preparation method and an application method thereof.
Background
Mosquitoes are one of the main vector pests and have the risk of transmitting malaria, epidemic encephalitis, dengue fever, yellow fever and other diseases. In daily life, application of a repellent is one of the common methods for preventing mosquito bites, and the repellent can be classified into a chemically synthesized repellent and a plant-derived repellent.
The repellent is a chemical substance capable of volatilizing special odor, and can prevent insects from being close after being smelled so as to achieve the repellent effect. The repellent has no insecticidal effect, and can prevent the population in field activity from being bitten and attacked by insects within a certain period of time. The most widely used chemical repellents at present are deet, mosquito repellent ester, pacific et al. The synthetic repellent has the advantages of good effect, long mosquito repelling time and the like, and is favored by people. However, the mosquito prevention and control agent also brings people's attention to the toxic and side effects of the mosquito prevention and control agent on human bodies. The DEET of the mosquito repellent is continuously reported in recent years to have side effects on human bodies and certain harm to the environment. The French research shows that DEET has an inhibitory effect on the activity of mammalian CNS acetylcholinesterase. In the actual use of the DEET, the problems of excessive absorption of skin and the like exist, in addition, the symptoms of urticaria syndrome, anaphylactic reaction, heartbeat reduction and the like of children have a dense and indispensible relationship with the excessive use of the DEET, and the report shows that the DEET has enhanced toxicity and has a certain threat to the life health of human beings when being mixed with the carbamate pesticide for use. With the increasing interest of people in health and environmental protection, especially, the sanitary insecticide is used in the living and living environment of people, and has direct contact with human bodies, so the requirements on the safety of the sanitary insecticide are higher and stricter.
As can be seen, research and development of new safe, natural mosquito repellents has become urgent, and plant-derived repellent, menthanediol, extracted from natural eucalyptus oil is receiving increasing attention from researchers.
Disclosure of Invention
Technical problem to be solved
The invention aims to provide the mosquito repellent containing the menthanediol, which is environment-friendly, harmless to human bodies, fresh in smell and environment-friendly.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the mosquito repellent product containing the menthanediol comprises the following components in percentage by mass:
3.0 to 15.0 percent of menthane diol, 8.0 to 12.0 percent of 95 percent alcohol, 0.1 to 0.6 percent of emulsifying agent, 0.1 to 0.8 percent of humectant, 0.1 to 1.0 percent of preservative, 1.0 to 5.0 percent of surfactant, 0.1 to 0.6 percent of stabilizer, 1.0 to 5.0 percent of flavoring agent decanol, 0.001 to 0.005 percent of antioxidant, 0.1 to 1.0 percent of bisabolol, 0.2 to 1.5 percent of salicylic acid, 0.001 to 0.005 percent of menthol, 0.1 to 1.0 percent of citronella essential oil, 0.1 to 3.0 percent of eucalyptus oil of lemon and 70 to 80 percent of deionized water.
As a further scheme of the invention: the emulsifier is PG40 hydrogenated castor oil.
As a further scheme of the invention: the humectant is ethylhexyl glycerol.
As a further scheme of the invention: the surfactant is octyl/decyl glucoside.
As a further scheme of the invention: the stabilizer is octanediol.
As a further scheme of the invention: the antioxidant is citric acid.
As a further scheme of the invention: the deionized water content is 75%;
as a further scheme of the invention: the Ph of the mosquito repellent product is 6.0.
The invention also provides a preparation method of the mosquito repellent product containing the menthanediol, which comprises the following steps:
1) Putting the menthanediol and the alcohol into a clean container according to the mass ratio, completely dissolving the menthanediol and the alcohol by water bath at 50 ℃, and uniformly stirring the materials;
2) Adding emulsifier, humectant, antiseptic, surfactant, stabilizer, flavoring agent decanol, antioxidant, bisabolol, salicylic acid, menthol, citronella essential oil, and Eucalyptus citriodora oil into quantitative ionized water;
3) The solution of 1) was added to 2) and the solution was stirred to milky.
The invention also provides an application method of the mosquito repellent product containing the menthanediol, which is characterized in that: the mosquito repellent is coated on the protection part with the coating dose of 3mg/cm 2 。
Compared with the prior art, the invention provides a mosquito repellent product containing the menthanediol and a preparation and application method thereof, and the mosquito repellent product has the following beneficial effects:
the mosquito repellent containing the menthanediol is a water-based milky white product, contains 10% of the menthanediol, has remarkable mosquito repellent effect, solubilizes the menthanediol by the joint coordination of hydrogenated castor oil, decyl glucoside, octyl glycol and alcohol, greatly reduces the alcohol content and improves the safety.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Embodiment one:
the raw material components and the proportions of the mosquito repellent product containing the menthanediol are shown in the first proportion (shown in the table 1), the second proportion (shown in the table 2) and the third proportion (shown in the table 3).
First match of
Table 1 two proportions
Table 2 three proportions
| Composition of the components | Proportioning of |
| Monenediol | 15％ |
| Hydrogenated castor oil (emulsifier) | 0.5％ |
| Phenoxyethanol (preservative) | 0.5％ |
| Ethyl hexyl glycerol (humectant) | 0.5％ |
| Octyl/decyl glucoside (surfactant) | 3％ |
| Alcohol with concentration of 95% | 10％ |
| Octanediol (stabilizer) | 0.2％ |
| Citric acid (antioxidant) | 0.2％ |
| Perfume mixing agent decyl alcohol | 0.3％ |
| Bisabolol | 0.3％ |
| Salicylic acid | 0.5％ |
| Menthol crystal | 0.1％ |
| Citronella essential oil | 0.5％ |
| Eucalyptus citriodora leaf oil | 1％ |
| Deionized water | 67.4％ |
Table 3 method of preparing mosquito repellent products containing menthanediol:
1) Putting the menthanediol and the alcohol into a clean container according to the mass ratio, completely dissolving the menthanediol and the alcohol by water bath at 50 ℃, and uniformly stirring the materials;
2) Adding emulsifier, humectant, antiseptic, surfactant, stabilizer, flavoring agent decanol, antioxidant, bisabolol, salicylic acid, menthol, citronella essential oil, and Eucalyptus citriodora oil into quantitative ionized water;
3) The solution of 1) was added to 2) and the solution was stirred to milky.
Among them, the role of the menthanediol: the menthanediol has insect repellent property, and the biting probability of mosquitoes can be greatly reduced by coating; the combination of the menthanediol and other insect repellents has a synergistic effect, and can greatly increase the insect repellent efficiency.
Compared with the traditional mosquito repellent product, namely the deet, the technology has the following advantages: firstly, the plant-derived repellent has better safety and environmental protection, small toxic and side effects on human bodies and fresh smell; secondly, the insect repellent mechanism is unique, and the insects are not easy to generate drug resistance; thirdly, the corrosion to plastics and leather does not exist.
Aedes aegypti and aedes albopictus belong to the order of the sheath diptera and are important sanitary pests for transmitting diseases, the average protection time provided by the menthanediol with the concentration of more than 10% exceeds 4 hours, and the higher the content of the menthanediol in the repellent is, the longer the protection time can be provided.
Embodiment two:
examples: the indoor efficacy effect experiment is carried out on the menthanediol product of our company and the similar mosquito repellent product on the market, and the repellent effect is tested by referring to the national standard of the people's republic of China, namely the indoor efficacy evaluation/repellent GB/T13917.9-2-9 of pesticide registration sanitary pesticide.
Under laboratory conditions (laboratory room 4m x 3m, temperature 26 ℃ ± 1 ℃ and humidity 65% ± 5%), the test was performed in a mosquito cage (30 cm x 25 cm) containing 100 aedes albopictus 3 days after eclosion, 4 volunteers (two men and two women) were washed clean with their hands and dried, and were put on medical latex gloves with a 4cm x 4cm notch cut in the back of their hands, after which their hands were put in the mosquito cage for 2min to test the aggressiveness of mosquitoes (stop number was 20 or more, as acceptable). In the experiment, one hand is used as a blank control, and the other hand is directly sprayed with the first, second, third and two common mosquito repellent products A and B in the market at the exposed part of the back of the hand, wherein the dosage is 3mg/cm 2 . After natural air drying, putting the hands into a mosquito cage for 2min for testing, and testing once every 1h, wherein the test is continued until the first mosquito is observed to stop or try to bite, and the test is regarded as complete protection failure. Experiments were repeated 3 times, and the results of the experiments were averaged for each experiment. The measured results are shown in Table 4:
TABLE 4 effective protection time of different repellent spray on mosquitoes
| Grouping | Repeat 1 | Repeat 2 | Repeat 3 | Average value (h) |
| First match of | 1.3 | 1.2 | 1.5 | 1.33 |
| Second proportion | 4.0 | 4.3 | 4.5 | 4.26 |
| Three proportions | 6.3 | 6.5 | 6.1 | 6.3 |
| Product A | 4.2 | 4.4 | 4.1 | 4.23 |
| Product B | 4.2 | 4.5 | 4.5 | 4.4 |
The final result refers to the national standard of the people's republic of China, namely, the indoor pesticide effect evaluation/repellent GB/T13917.9-2-9 evaluation of pesticides for registering sanitary pesticides, and the pesticide effect evaluation is carried out according to the effective protection time (h) of the repellent to the testers, wherein the pesticide effect result is divided into A, B two stages, and unqualified products are obtained when the B-stage standard is not met (the A-stage effective protection time is more than or equal to 6.0h, and the B-stage effective protection time is more than or equal to 4.0 h.)
The proportion of the three is more than or equal to 6.0h, which is a class A product; the ratio of the second to the third is more than or equal to 6.0h and more than or equal to 4.0h, and the product is the B-class product; the first proportion is less than or equal to 4.0, and is an unqualified product, so the second proportion and the third proportion are recommended.
And the third proportion is more excellent in insect repellent effect and long in lasting effect compared with the repellent in the market.
The above description is only of the preferred embodiments of the present invention; the scope of the invention is not limited in this respect. Any person skilled in the art, within the technical scope of the present disclosure, may apply to the present invention, and the technical solution and the improvement thereof are all covered by the protection scope of the present invention.
Claims (10)
1. A mosquito repellent product comprising menthanediol, characterized in that: comprises the following components in percentage by mass:
3.0 to 15.0 percent of menthane diol, 8.0 to 12.0 percent of 95 percent alcohol, 0.1 to 0.6 percent of emulsifying agent, 0.1 to 0.8 percent of humectant, 0.1 to 1.0 percent of preservative, 1.0 to 5.0 percent of surfactant, 0.1 to 0.6 percent of stabilizer, 1.0 to 5.0 percent of flavoring agent decanol, 0.001 to 0.005 percent of antioxidant, 0.1 to 1.0 percent of bisabolol, 0.2 to 1.5 percent of salicylic acid, 0.001 to 0.005 percent of menthol, 0.1 to 1.0 percent of citronella essential oil, 0.1 to 3.0 percent of eucalyptus oil of lemon and 70 to 80 percent of deionized water.
2. A mosquito repellent product according to claim 1 comprising a menthanediol, wherein: the emulsifier is PG40 hydrogenated castor oil.
3. The mosquito repellent product comprising menthanediol according to claim 1, and the preparation and application methods thereof, characterized in that: the humectant is ethylhexyl glycerol.
4. A mosquito repellent product according to claim 1 comprising a menthanediol, wherein: the surfactant is octyl/decyl glucoside.
5. A mosquito repellent product according to claim 1 comprising a menthanediol, wherein: the stabilizer is octanediol.
6. A mosquito repellent product according to claim 1 comprising a menthanediol, wherein: the antioxidant is citric acid.
7. A mosquito repellent product according to claim 1 comprising a menthanediol, wherein: the deionized water content is 75%.
8. A mosquito repellent product according to claim 1 comprising a menthanediol, wherein: the Ph of the mosquito repellent product is 6.0.
9. A method of preparing a mosquito repellent product comprising menthanediol according to any one of claims 1-8 comprising the steps of:
1) Putting the menthanediol and the alcohol into a clean container according to the mass ratio, completely dissolving the menthanediol and the alcohol by water bath at 50 ℃, and uniformly stirring the materials;
2) Adding emulsifier, humectant, antiseptic, surfactant, stabilizer, flavoring agent decanol, antioxidant, bisabolol, salicylic acid, menthol, citronella essential oil, and Eucalyptus citriodora oil into quantitative ionized water;
3) The solution of 1) was added to 2) and the solution was stirred to milky.
10. A method of using a mosquito repellent product comprising menthanediol according to any one of claims 1-8, wherein: the mosquito repellent is coated on the protection part with the coating dose of 3mg/cm 2 。
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