CN101491491B - Long-acting mosquito-driving condensation dew - Google Patents
Long-acting mosquito-driving condensation dew Download PDFInfo
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- CN101491491B CN101491491B CN2009101188375A CN200910118837A CN101491491B CN 101491491 B CN101491491 B CN 101491491B CN 2009101188375 A CN2009101188375 A CN 2009101188375A CN 200910118837 A CN200910118837 A CN 200910118837A CN 101491491 B CN101491491 B CN 101491491B
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Abstract
The invention relates to a long-acting mosquito expelling gel and belongs to the field of daily chemical goods. The long-acting gel comprises an A phase, a B phase and a C phase in percentage by weight: the A phase: 40.00 to 60.00 percent of deionized water, 0.20 to 1.20 percent of carbomer resin, 0.05 to 1.00 percent of hydroxypropylmethyl cellulose and 0.01 to 1.00 percent of disodium EDTA; theB phase: 10.00 to 30.00 percent of alcohol, 10.00 to 25.00 percent of dimethyl phthalate, 0 to 10.00 percent of geranium extract and 0.01 to 1.00 percent of menthyl lactate; and the C phase: 0.10 to 1.00 percent of diisopropylamine. The long-acting mosquito expelling gel has a mild formulation, comfortable coating feel, is fresh and not sticky, has safe use and remarkable mosquito expelling effect which reaches over 10 hours and meets requirement of medicine specially needed for military.
Description
Technical field
The present invention relates to the daily chemical product field, particularly relate to a kind of long-acting mosquito-driving condensation dew.
Background technology
Common in the market mosquito-proof product mainly contains four big classes: the first kind is that kill mosquito aerosol, second class are that mosquito incense, the 3rd class are that repellant, the 4th class are the propellants that needs dilution to use.The most frequently used mainly is first three class.
Aerosol: mainly be divided into two kinds according to the solvent difference.The one, do the oil type of solvent with kerosene, the 2nd, do the aqua type of solvent with water.On the whole, the aerosol of oil type is owing to can be attached to the mosquito body surface more enduringly, and insecticidal effect is better than aqua type; But the aerosol of oil type has a kind of penetrating odor, is difficult for being accepted by the people.Therefore, the aqua type and the scentless oil type product of little, the no environment influence of abnormal smells from the patient are better selections.Aerosol belongs to the contact killing type mosquito repellent product, is mainly used in emergency processing.That is to say, when we find mosquito, as long as a small amount of sprinkling that aim at the mark just can reach the effect killed fully.A large amount of ways of spraying aerosols in airtight bedroom were worthless one or two hour before the somebody slept, because aerosol can be deposited to ground after spraying very soon, did like this and can only smoke the people and can not mosquito killing.
Mosquito incense: comprise incense coil, electric mosquito repellent tablet and vaporizer mosquito liquid, its common characteristic is that repelling effect is comparatively lasting, has 8 to 12 hours defencive function usually.The smog that incense coil is distributed when lighting can stimulate nasal cavity and oral mucosa, causes the respiratory tract discomfort, and family uses fewer and feweri at present; Electric mosquito repellent and vaporizer mosquito liquid are smokeless, clean, moderate, up to the present do not find toxic and side effects as yet, thereby family preferably uses.The suggestion using method: sleep and door and window was closed in preceding 1 to 2 hour, igniting mosquito-repellent incense is treated door and window to be opened in bed in the inlet chamber again, to maintain the circulation of air.The benefit of doing like this is, evaporate in the air from the igniting mosquito-repellent incense to the insecticide and keeps finite concentration to need a process, and 1 to 2 hours igniting mosquito-repellent incenses can kill indoor existing mosquito in advance; After opening wide door and window, though indoor insecticide concentration reduces, be not enough to the mosquito that causes death, but still can play the effect of driveing, its concentration can not be detrimental to health again.
In general, two kinds of measures only are applicable to the confined spaces such as indoor more than.Outdoor, because cross-ventilation constantly enters the diluting effect of insecticide and the mosquito outside the effective range, these two kinds of measures are difficult to the effective protective effect of performance, so the anophelifuge product of direct use on skin just occurred.
Anophelifuge: be high-tech mosquito repellent product of new generation, derived multiple dosage form in the market.As, mosquito-repellent perfume, mosquito-repellent water, anophelifuge balsam, mosquito-dispelling cream or the like.Anophelifuge has easy to use, is not subjected to the characteristics of the restriction of time and service condition, directly be applied on the exposed skin and can play repelling effect, as essential balm, mosquito do not sting, mosquito-dispelling cream etc.Be particularly suitable for camping, field work personnel such as army, oil field, geology, forestry and the night attendant of factory use.
It is multiple that anophelifuge effective ingredient on the domestic and international market has pyrethrin mosquitofugal oil, dimethyl phthalate (BAAPE), dihydropyrone, octylene glycol, diethyltoluamide (DETA or title DEET) etc. at present, and can reach long-acting mosquito-driving and toxic and side effects less mainly contain two kinds, diethyltoluamide and up-to-date succedaneum dimethyl phthalate.
Diethyltoluamide (DEET) is the practical application effect of generally acknowledging a wide spectrum mosquito repellent agent preferably always for a long time.The various insects of sucking blood such as it can repellent such as mosquito, flea, flat louse, black fly, thorn fly, deerfly, horse botfly, sand fly, stable fly, midge, demodicid mite, buffalo gnat, Ticks.Have that repellent effect is good, advantage such as applied range, toxicity are little.
The army of developed countries such as present U.S. Germany all selects for use has equipped mosquito-repellent.U.S. army's mosqito repellent of research at present mainly contains two kinds, the promptly common solution-type repellant and the long-acting type repellant of new equipment.There is following problem in use in regular solution type repellant: (1) is because the quick volatilization of diethyltoluamide, can not be satisfied the requirement of army's field training at the repellent persistent period short (0.5-2 hour); (2) be coated with greasy feeling, comfort is poor.(3) because the regular solution type is absorbed by the body easily, might cause untoward reaction.
Summary of the invention
A kind of long-acting mosquito-driving condensation dew comprises A, B, the C phase of following weight percentage.
A phase: deionized water 40.00～60.00%, carbomer 0.20～1.20%, hydroxypropyl methylcellulose 0.05～1.00%, EDTA disodium 0.01～1.00%.
B phase: ethanol 10.00～30.00%, dimethyl phthalate 10.00～25.00%, menthyl lactate 0.01～1.00%, Flos Pelargonii Hortori 0～10.0%.
C phase: diisopropylamine 0.10～1.00%.
Preferably:
A phase: deionized water 50.00～60.00%, carbomer 0.50～1.00%, hydroxypropyl methylcellulose 0.1～0.50%, EDTA disodium 0.1～0.50%.
B phase: ethanol 10.00～20.00%, dimethyl phthalate 20.00～25.00%, menthyl lactate 0.05～0.50%, Flos Pelargonii Hortori 2～8%.
C phase: diisopropylamine 0.2～0.50%.
The preparation method of long-acting mosquito-driving condensation dew comprises the steps:
1, A is divided by, and the EDTA disodium is outer respectively expects to be heated to 85 ℃, stir to add the EDTA disodium down, and homogenizing 5 minutes, insulated and stirred 20 minutes is guaranteed to dissolve complete.
2, B each material in is mutually mixed, stirred 5 minutes.
3, A is cooled to mutually and adds the good B phase of dissolving after 40 ℃, stirs vacuum homogenizing 5 minutes 10 minutes.
4, add the C phase, stirred 10 minutes, and continue to be cooled to below 35 ℃ discharging.
The present invention adopts safer dimethyl phthalate as mosquito-repellent, change common water preparation or cream cream type into skin sense salubrious gel dosage form simultaneously, can form a thin film at skin surface after smearing health, reduce dispersing of dimethyl phthalate, make anophelifuge timeliness of the present invention reach more than 10 hours, be fit to very much field worker and use; The gel dosage form is smeared the no greasy feeling in back, and also is added with ethanol in this prescription, and the volatilization of ethanol has increased the refrigerant sense of skin after use, also is added with menthyl lactate simultaneously in prescription, can keep long refrigerant impression.
Adopt the organic amine diisopropylamine as nertralizer among the present invention, solved the problem that to add more amount ethanol in the prescription.
The present invention also is added with Flos Pelargonii Hortori as the dimethyl phthalate composite synergist, thereby repellent effect was brought up to more than 10 hours.
This product effect:
◆ use more convenient, more comfortable, safer, more efficient.
This product is designed to gel, and product does not have the high fluidity of water preparation, so can adopt the plastic flexible pipe packing, sealing, good stability are easy to carry.
The gel dosage form of hose packing, the easier control of product taking-up amount rests on hand and can not trickle, and uses more convenient.
This prescription does not have emulsion process, does not use emulsifying agent, and it is clearly not sticky to smear the back dermal sensation, pollution clothes not.Also be applicable to child's tender skin of children and sensitivity skin matter, use more comfortable.
This product adopts safe mosquito dispersing technology, does not contain harmful DEET, and product safety is non-stimulated, and skin and mucosa are had no side effect, do not have anaphylaxis, uses safer.This product contains 15% dimethyl phthalate raw material, adopts advanced prescription, and the production technology of strict control efficiently prevents the mosquito invasion, and lastingly effectively bring into play protective effect more than 10 hours effective acting time.
◆ the scope of application is wide, and product efficacy is complete.Adopt the advanced technology of thin polymer film slow release in the prescription; sweating, still having lasting effectiveness under the situation such as friction; use in the area that is particularly suitable for army's field work, countryside travelling, jungle is movable and takes a trip to the vector disease to threaten, no matter the same efficient protection in indoor and outdoor.Simultaneously, except that mosquito is had the repellent action, various insects such as flat louse, fly, louse, wasp, Apis also there is very strong repellent effect.
At the special development of the characteristics of outdoor activities, for the soldier that is engaged in field operations, the personnel that carry out the scientist of field study exploration and be engaged in plantation, tourism and night duty provide long-lasting protection to mosquito.
The specific embodiment
Embodiment
Technology:
1, A is divided by, and the EDTA disodium is outer respectively expects to be heated to 85 ℃, stir to add the EDTA disodium down, and homogenizing 5 minutes, insulated and stirred 20 minutes is guaranteed to dissolve complete.
2, B each material in is mutually mixed, stirred 5 minutes.
3, A is cooled to mutually and adds the good B phase of dissolving after 40 ℃, stirs vacuum homogenizing 5 minutes 10 minutes.
4, add the C phase, stirred 10 minutes, and continue to be cooled to below 35 ℃, detects qualified after, the filtration of 200 order filter clothes below 30 ℃ discharging.
Remarks: this product is volatile, will seal tight during storage.
Experimental example (adopt and implement 1 product)
One, effect evaluation
(1) laboratory repellent experiment effect:
Method of testing is carried out the test of pesticide effectiveness according to the indoor harmacological effect evaluation methodology of GB/T17322.10-1998 agriculture chemical registration hygienic insecticide.Do one group of blank experiment before the experimenter tests, the observation mosquito has no significant difference to different experiments personnel's attack, and selects 8 of the qualified experimenters of attack experiment.The experimenter who selects wears the altex glove that the back of the hand exposes 4cm * 5cm skin, smear long-acting mosquito-driving condensation dew by 8ul/cm2 dosage in right-hand man's exposure portion, hands is stretched into stop 3min in the cage, every 1h test 1 time, till having 1 mosquito to begin to attack, write down effective repellent time.The result shows that the effective repellent of long-acting mosquito-driving frost laboratory was for up to 10.5 hours.
(2) outdoor on-the-spot repellent experiment effect:
At dusk, select other two the representative areas in outdoor grove and lawn behind the rain in August of Beijing, the volunteer carries out field experimentation as study subject.The experimenter all wears the long sleeves BDU, the left side lower limb bottom of s trouser leg has been drawn, get the about 4g of long-acting mosquito-driving gel respectively, evenly be applied to the following ankle joint of left lower limb knee joint with the upper part, keep the coating position exposed always, every half an hour or 1 hour the intensive place of mosquito in the outdoor grove stood 15 minutes, observe the mosquito bite situation at any time, notify the time of biting and record at once.Establish totally 3 groups of blank and commercially available prod (six refreshing mosquito-repellent perfumes) matched groups simultaneously, every group 4 people.
Effective percentage=experiment number-bite number/experiment number * 100%
Easy hydrops after raining, there was dampness in the air, and weather is sultry, and mosquito is more in the grove of meadow.Mosquito belongs to anopheles, ant mosquito, and attack is stronger.Requirement to medicament against mosquitoes mainly is long-acting nontoxic.
At the beginning of Beijing 9 months, rainy weather, by river course, rural area, suburb, korneforos sewage mosquito fly is rampant unusually.The volunteer carries out field experimentation as study subject.The experimenter all wears the long sleeves BDU, the left side lower limb bottom of s trouser leg has been drawn, get the about 4g of long-acting mosquito-driving condensation dew respectively, evenly be applied to the following ankle joint of left lower limb knee joint with the upper part, keep the coating position exposed always, other the standing half an hour in the river course observed the mosquito bite situation in car, and then to the river course other standing returned in the car in 20 minutes, observe mosquito bite situation and record according to requirement of experiment.Establish totally 3 groups of blank and commercially available (six refreshing mosquito-repellent perfumes) matched groups simultaneously, every group 4 people.
Outdoor field study result shows that the repellent effect of long-acting mosquito-driving condensation dew obviously is better than the commercially available prod; Because of from different places, the density of mosquito, attack etc. are variant, cause repellent effect also to produce difference in addition.Effective repellent time that the outdoor grove length of side is imitated mosquito-driving condensation dew is approximately 8～9 hours, and effective repellent time that the river course length of side is imitated mosquito-driving condensation dew is greatly about about 7 hours, and effective repellent time of six refreshing mosquito-repellent perfumes has only 3 hours.
Two, safety evaluatio
(1) skin irritation test: according to the pertinent regulations of state, adopt human trial, the result shows: long-acting mosquito-driving condensation dew is to the basic nonirritant of human body skin.
(2) skin anaphylactic test: select healthy volunteer 10 people, test after smearing this product in accordance with regulations, the cycle is 14 days, and the result proves that long-acting mosquito-driving condensation dew does not have sensitization substantially to human body skin.
(3) acute eye irritation test: carry out tame white mice animal experiment according to the pertinent regulations of state, the result proves that the long-acting mosquito-driving frost is to the eyes nonirritant.
(4) other untoward reaction: observe about 30 people of open-air experimenter person, not seeing has whole body or local untoward reaction.
Three, stability test
According to the relevant new drug estimation of stability index of country, the quality of long-acting mosquito-driving condensation dew the test of anti-height (low) temperature, strong illumination test have been carried out, accelerated stability test and long-term stable experiment, the result shows this controllable product quality, and stable in properties determines that tentatively its effect duration is 36 months.
In sum, prove that long-acting mosquito-driving condensation dew is safe in utilization, effect is remarkable, and steady quality meets field work guarantor person's medicine requirement.
Claims (2)
1. long-acting mosquito-driving condensation dew, A, the B, the C phase that comprise following weight percentage, A phase: deionized water 40.00～60.00%, carbomer 0.20～1.20%, hydroxypropyl methylcellulose 0.05～1.00%, EDTA disodium 0.01～1.00%, B phase: ethanol 10.00～30.00%, dimethyl phthalate 10.00～25.00%, Flos Pelargonii Hortori 0～10.00%, menthyl lactate 0.01～1.00%, C phase: diisopropylamine 0.10～1.00%; Its preparation method comprises the steps: 1, A is divided by, and the EDTA disodium is outer respectively expects to be heated to 85 ℃, stirs to add EDTA disodium, homogenizing 5 minutes down, insulated and stirred 20 minutes is guaranteed dissolving fully, 2, B each material in is mutually mixed, stirred 5 minutes, 3, A is cooled to mutually and adds the good B phase of dissolving after 40 ℃, stirs vacuum homogenizing 5 minutes 10 minutes, 4, add the C phase, stirred 10 minutes, and continue to be cooled to below 35 ℃, 200 order filter clothes below 30 ℃ filter discharging.
2. long-acting mosquito-driving condensation dew according to claim 1, A phase: deionized water 50.00～60.00%, carbomer 0.50～1.00%, hydroxypropyl methylcellulose 0.1～0.50%, EDTA disodium 0.1～0.50%, B phase: ethanol 10.00～20.00%, dimethyl phthalate 15.00～20.00%, Flos Pelargonii Hortori 2.00～8.00%, menthyl lactate 0.02～0.50%, C phase: diisopropylamine 0.2～0.50%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101188375A CN101491491B (en) | 2009-02-04 | 2009-03-03 | Long-acting mosquito-driving condensation dew |
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| CN200910077932 | 2009-02-04 | ||
| CN200910077932.5 | 2009-02-04 | ||
| CN2009101188375A CN101491491B (en) | 2009-02-04 | 2009-03-03 | Long-acting mosquito-driving condensation dew |
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| CN101491491B true CN101491491B (en) | 2011-01-05 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101843566B (en) * | 2010-03-31 | 2012-10-17 | 北京日蒙生物科技有限公司 | Mosquito repellent and preparation method thereof |
| CN102007943B (en) * | 2010-11-03 | 2013-04-24 | 华南理工大学 | Aqueous tick repellent aerosol |
| CN102551580B (en) * | 2012-01-12 | 2014-09-10 | 杭州国光旅游用品有限公司 | Multifunctional moist towelette |
| CN102987869B (en) * | 2012-12-19 | 2015-06-03 | 深圳市利勇安硅橡胶制品有限公司 | Method for fabricating silica gel pad capable of being used as pad and bag and silica gel pad |
| CN103356440B (en) * | 2013-07-26 | 2015-02-18 | 付永旭 | Centella acne-cleaning speckle-removing gel and preparation method thereof |
| CN105726416A (en) * | 2016-04-09 | 2016-07-06 | 福建省金鹿日化股份有限公司 | Gel with mosquito repelling, swelling subsiding and itching relieving functions |
| CN110547292A (en) * | 2019-09-06 | 2019-12-10 | 上海中华药业有限公司 | Mosquito-repellent gel and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186604A (en) * | 1997-12-23 | 1998-07-08 | 许水利 | Mosquito-repellent liquid and its compounding technology |
| US6451844B1 (en) * | 1998-09-18 | 2002-09-17 | Quest International Bv | Use of menthyl-2 pyrrolidone-5-carboxylate as an insect repellent |
| CN1548028A (en) * | 2003-05-13 | 2004-11-24 | 上海家化联合股份有限公司 | Mosquito-repellent toilet water |
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2009
- 2009-03-03 CN CN2009101188375A patent/CN101491491B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186604A (en) * | 1997-12-23 | 1998-07-08 | 许水利 | Mosquito-repellent liquid and its compounding technology |
| US6451844B1 (en) * | 1998-09-18 | 2002-09-17 | Quest International Bv | Use of menthyl-2 pyrrolidone-5-carboxylate as an insect repellent |
| CN1548028A (en) * | 2003-05-13 | 2004-11-24 | 上海家化联合股份有限公司 | Mosquito-repellent toilet water |
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| CN101491491A (en) | 2009-07-29 |
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