CN108771640A - It is a kind of to be promoted to menthyl -3,8- glycol effects without the mosquito-proof composition of ethyl alcohol - Google Patents
It is a kind of to be promoted to menthyl -3,8- glycol effects without the mosquito-proof composition of ethyl alcohol Download PDFInfo
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- CN108771640A CN108771640A CN201811042218.8A CN201811042218A CN108771640A CN 108771640 A CN108771640 A CN 108771640A CN 201811042218 A CN201811042218 A CN 201811042218A CN 108771640 A CN108771640 A CN 108771640A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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Abstract
The present invention relates to the mosquito-repellent technical field that daily chemical products class may be used at human skin surface, specially one kind can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol.The present invention is by selecting the grease, it can preferably dissolve to menthyl -3 at normal temperatures, 8- glycol, also has certain solvability under cryogenic simultaneously, make it that can uniformly be sprawled in skin surface, and the water resistant film forming agent described in adding can play the role of collaboration and sprawl and improve to menthyl -3,8- glycol is in the skin surface residence time, reduce the influence that outside moisture is formed by skin surface with moisture in itself sweat mosquito-proof film, promote mosquito-proof effect, it can help, to menthyl -3,8- glycol solubilising, crystallization to be prevented to be precipitated additionally by addition butanediol.By coordinating the proportioning of grease and other components in composition, the product that acquisition stable system and skin sense have been experienced.
Description
Technical field
The present invention relates to the mosquito-repellent technical fields that daily chemical products class may be used at human skin surface, more particularly to
It can prevent from crystallizing menthyl -3,8- glycol and be precipitated, can uniformly sprawl film forming on a skin surface, to be promoted to peppermint
The mosquito-proof effect of base -3,8- glycol and without ethyl alcohol without the mosquito-proof composition of ethyl alcohol.
Background technology
To menthyl -3,8- glycol, abbreviation PMD is a kind of active constituent of repellant, is from lemon eucalyptus oil at first
It was found that and gained after being modified to lemon eucalyptus oil, being a kind of unique US and European to menthyl -3,8- glycol allows to make
The natural activity component of insect repellent.Not only there is preferable repelling effect to menthyl -3,8- glycol, to tick worm
It is same effective, while its antibacterial and refrigerant performance makes it be widely used in daily use chemicals and field of food.But to menthyl -3,8-
Crystal habit is presented in glycol at normal temperatures, and fusing point is mostly to make compared with skin temperature height, current mosquito repellent product or related patents technology
Its solubilising is used with high level alcohol or polyalcohol.It is used on domestic market to menthyl -3,8- glycol as main anti-
The product of mosquito ingredient is with surfactant compound solubilising using ethyl alcohol or ethyl alcohol to menthyl -3,8- glycol, such combination
Although form can ensure, to menthyl -3,8- glycol uniform dissolution in formula or stably dispersing, to be applied to skin
Surface can be precipitated menthyl -3,8- glycol after ethyl alcohol volatilization in the form of crystal, and mosquito-proof efficiency can be reduced largely.State
Interior 105816362 A of patent CN disclose a kind of infant's mosquito-repellent liquid, which is the polyalcohol using high-content and fits
Cremophor RH40 is measured by Meng's glycol (to menthyl -3,8- glycol) solubilising in water-based system, although not needing alcohol increasing
It is molten, but after the problem of such formula system is used in skin surface, do not tolerate washing away for skin sweat, it is a large amount of it is water-soluble at
Point use so that mosquito-proof ingredient setup is worse on the skin, this is why using high level to menthyl -3,8-
The still undesirable reason of the mosquito-proof effect of glycol, why many products effect under laboratory test condition can receive still in fact
The reason of border using effect is deteriorated.
The technical issues of natural mosquito-proof ingredient is to menthyl -3,8- glycol is used based on existing, needs one kind that can ensure
Skin surface can be uniformly sprawled while can rested on the long period in skin surface to menthyl -3,8- glycol, is played anti-
Mosquito efficiency, and have certain water repelling property, it prevents sweat or its moisture from being washed away to active ingredient, promotes mosquito-proof performance.
Invention content
The present invention is led to for the above problem existing for the existing anophelifuge with to menthyl -3,8- glycol for active constituent
Cooperation after using specific grease and water resistant film forming agent according to a certain ratio and with other components, provides a kind of to menthyl -3,8-
Glycol can uniformly sprawl film forming in skin surface while the long period can rest on skin surface, promote the nothing of mosquito-proof effect
The mosquito-proof composition of ethyl alcohol.
To achieve the above object, the present invention uses following technical scheme.
One kind can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, contain following mass percent
Each component：
2-10% to menthyl -3,8- glycol,
The grease of 4-40%,
The emulsifier of 0.5-10%,
The rheology modifier of 0.15-3%,
The water resistant film forming agent of 0.3-3%,
The 1,3-BDO of 5-10%,
Surplus is water.
Preferably, the grease is the polarity grease that fusing point is less than 0 DEG C.
It is furthermore preferred that the grease is selected from carbonic acid ethylhexanoate, hexyl decyl alcohol, octyl dodecanol, isooctadecanol, meat
At least one of isopropyl myristate, sad Propylheptyl, Dermol 105.
It is furthermore preferred that the grease is (2-4) with the mass ratio to menthyl -3,8- glycol:1.
The present invention can preferably be dissolved at normal temperatures by selecting above-mentioned fusing point to be less than 0 DEG C and having polar grease
To menthyl -3,8- glycol, while also having certain solvability under cryogenic.Above-mentioned grease containing in the composition
It is better to measure the higher solute effect to menthyl -3,8- glycol, but stability and skin sense because that need to consider composition, oil need to be coordinated
The proportioning of other components is to obtain the product that system stabilizers skin sense has been experienced in fat and composition.
Preferably, the emulsifier be selected from polysorbate esters, alkyl glucosides glycoside, alkyl sucrose esters, glyceride type,
Alkanol polyethenoxy ether class, polyoxyethylated alkyl esters, the smooth alkyl esters of sorb, polyglycereol alkyl esters, alkanol phosphate
At least one of class and their salt.
For the mentioned emulsifier that the present invention selects to skin safe, emulsifying capacity is stronger.
Preferably, it is total to be selected from alkyl vinyl pyrrolidinone copolymer, polyesters, acrylic acid (ester) class for the water resistant film forming agent
One kind in polymers, acrylic acid (ester)/octylacrylamido.
It is furthermore preferred that the water resistant film forming agent is selected from VP/ hexadecene copolymers, VP/ eicosene copolymers, polyester-
7, one kind in acrylic acid (ester) analog copolymer, acrylic acid (ester)/octylacrylamido.
Preferably, the rheology modifier is selected from least one of hydrophilic gel, hydrophilic and oleophilic gelling agent.
It is furthermore preferred that the rheology modifier is selected from xanthans, aluminum magnesium silicate, lithium metasilicate magnesium, microcrystalline cellulose, cellulose
Glue, montmorillonite, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, ammonium acryloyldime-thyltaurate/VP copolymerization
Object, ammonium acryloyldime-thyltaurate/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers, polyacrylate crosslinking are poly-
Close object -6, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, acrylic acid (ester) class/- 25 first of docosyl alcohol polyethers
At least one of base acrylate copolymer.
The above-mentioned rheology modifier that the present invention selects in aqueous environments its in the water phase of composition, can disperse, stablize,
Emulsification or suspension oil-phase component so that oil-phase component more stabilization will not be precipitated.Rheology modifier selects above-mentioned hydrophily solidifying
Jelly and hydrophilic and oleophilic gelling agent all have the performance of shear shinning, can be selected to be appropriate to different doses according to the difference of yield value
The viscosity of the gelling agent of type, composition is 500mPas to 100Pas etc., can be selective according to viscosity and yield value
It is combined into sprayable type, the dosage form of flow model or not flow-type ones appearance.
Preferably, the above can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, be sprayable
Dosage form, flowable dosage form or not flowable formulation.
The above can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, can also include being used for
The component for improving skin sense experience, the component for improving skin sense experience can be selected from dimethyl silicone polymer or hydrophilic modifying poly- two
Methylsiloxane, dimethiconol, ring five dimethyl silicone polymer, six dimethyl silicone polymer of ring and isononanoic acid
Different nonyl ester, different tridecanol isononoate, isomery dodecane, isomery hexadecane, saualane, silica, nylon, polymethyl
Sour methyl esters hollow ball etc. has at least one of the grease for improving skin sense.
The above can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, can also include auxiliary
Class emulsifier, assisted class emulsifier are selected from stearoyl-glutamic acid sodium, C20-22 alcohol, cetanol, stearyl alcohol, C14-22 alcohol, poly- sweet
At least one of oily -3 diisopstearates, -3 decylate of polyglycereol.
The above can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, can also include neutralizing
Agent, to neutralize alkyl phosphoric acid esters emulsifier and acrylic acid (ester) Type of Collective object；The neutralizer is selected from sodium hydroxide, hydroxide
One kind in potassium, triethanolamine, aminomethyl propanol, arginine.
The above can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, can also include anti-corrosion
Agent component prevents the growth of microorganism.
The above can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, can also include other
Annexing ingredient, other annexing ingredients are at least one in antioxidant, free radical scavenger, anti-inflammatory agent, chelating agent, essence
Kind, the specific choice of other annexing ingredients is depending on the characteristic of product design needs.
It is of the present invention promoted to menthyl -3,8- glycol effects without the mosquito-proof composition of ethyl alcohol be oil-in-water type
Composition.
Compared with prior art, the beneficial effects of the invention are as follows：
The inventive concept of the present invention is by selecting suitable grease and water resistant film forming agent and coordinating other components, form one
Kind mosquito-proof active constituent therein can uniformly sprawl film forming in skin surface and be retained in the mosquito-proof combination of skin surface for a long time
Object, mosquito-proof composition to skin protect mosquito-proof, the mosquito-proof mode of the existing mosquito-proof product of change in a manner of film, especially existing
Active ingredient is the mosquito-proof mode to the mosquito-proof product of menthyl -3,8- glycol, to menthyl -3,8- glycol in skin surface
Mosquito-proof barrier is formed in a manner of film, can effectively promote mosquito-proof effect to menthyl -3,8- glycol.
The present invention can preferably be dissolved to menthyl -3,8- glycol, simultaneously at normal temperatures by selecting suitable grease
Also have certain solvability under cryogenic, make it that can uniformly be sprawled in skin surface, and add the water resistant at
Film can play the role of collaboration and sprawl and improve to menthyl -3,8- glycol in the skin surface residence time, reduce outside water
Divide the influence for being formed by mosquito-proof film to skin surface with moisture in itself sweat, promote mosquito-proof effect, additionally by addition fourth
Glycol can help, to menthyl -3,8- glycol solubilising, crystallization to be prevented to be precipitated.By coordinating grease and other components in composition
The product that proportioning, acquisition stable system and skin sense have been experienced.
The present invention by use by a certain percentage specific grease, water resistant film forming agent and other components with to menthyl -3,
The natural mosquito proof active constituent in this source can preferably be applied in repellant product, plays most by 8- glycol compatibilities
Big efficiency solves the dependence when being formulated use to ethyl alcohol or high content poly-component alcohol to menthyl -3,8- glycol, solves simultaneously
Having determined to menthyl -3,8- glycol, it is uneven to be sprawled in skin surface, the problem of being easy by moisture interference.
The present composition is free of ethyl alcohol, can avoid excess ethyl alcohol use and is injured caused by skin, can also be achieved and avoid
Menthyl -3,8- glycol is crystallized and is precipitated and influences mosquito-proof effect, while the present composition helps to stablize and improve to thin
The mosquito-proof time of He Ji -3,8- glycol can reduce the use to menthyl -3,8- glycol within identical mosquito-proof effective time
Amount is reduced because to skin irritatin caused by menthyl -3,8- glycol.
The present composition changes dosage form by selecting suitable emulsifier with rheology modifier, is such as preparing with spray
Appropriate emulsifier can be selected to make entire composition system with relatively low with rheology modifier in the composition of mist ability
Viscosity, while have higher yield value and with shear shinning performance, for another example prepare with flowing or can not
It can achieve the goal by adjusting the dosage of rheology modifier when the composition of flowing.
In addition, contained in the present composition make to prevent without additional addition in composition to the amount of menthyl -3,8- glycol
Rotten agent has good from anti-corrosion ability.
Specific implementation mode
In order to more fully understand the technology contents of the present invention, with reference to specific embodiment to technical scheme of the present invention
Be described further and illustrate, following embodiment is only the section Example of the technology of the present invention, the technology of the present invention it is other specific
The mode that case study on implementation can refer to following embodiment is realized.
What the present invention used derives from from the extract of lemon eucalyptus leaf oil extract, or by lemon menthyl -3,8- glycol
Eucalyptus oil or citronellal obtain for Material synthesis.
Rheology modifier for the present invention can be following commercial goods, but be not limited to following commercial goods：
Xanthans includes but not limited to：Trade name KELTROL CG-T, KELTROL CG-SFT, KELTROL CG-F.
Aluminum magnesium silicate：Trade name VEEGUM R, VEEGUM Ultra.
Lithium metasilicate magnesium and montmorillonite：Trade name BENTONE EW, BENTONE LT.
Microcrystalline cellulose and cellulose gum：Trade name Avicel PC 611, MOISPRAY C.
Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers：Trade name SEPINOV EMT10,
SIMULGEL INS 100、SIMULGEL FL、SIMULGEL NS。
Ammonium acryloyl taurate/VP copolymer：Trade name Aristoflex AVC, Aristoflex AVC.
Polyacrylate cross-linked polymer -6：Trade name SEPIMAX ZEN.
Ammonium acryloyldime-thyltaurate/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers：Trade name
Aristoflex BLV、Aristoflex HMB。
Acrylic acid (ester) class/- 25 methacrylate copolymer of docosyl alcohol polyethers：Trade name Aculyn 28, Volarest
FL。
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers：Trade name CarbopolUltrez 21,
CarbopolUltrez 20、Carbopol ETD 2020、Pemulen TR-1、Pemulen TR-2、Pemulen EZ-4U。
Water resistant film forming agent for the present invention can be following commercial goods, but be not limited to following commercial goods：
VP/ eicosene copolymers：Trade name Antaron V-220.
Polyester -7：Trade name Lexfilm sun.
Acrylic acid (ester) analog copolymer：Trade name ERMACRYL AQF polymer.
Acrylic acid (ester)/octylacrylamido：Trade name DEMACRYL 79Polymer.
Embodiment 1-6
Embodiment 1-6 provides one kind and can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, respectively respectively
Contained component is as shown in table 1 below in the composition of embodiment.The composition of each embodiment each component shown in table 1 is made.
Preparation method can be that hydrophilic component in raw material and water are first mixed to form water phase, and lipophilic ingredients are mixed to form oil phase, so
Water phase is obtained into mixture i.e. composition with oil phase mixing homogeneous uniform afterwards, includes the formula of neutralizer for raw material, then also needs
Then neutralizer is added into mixture and is uniformly mixed and obtains composition.
The mass percent (wt.%) of each component in the composition of 1 embodiment 1-6 of table
Component definition in table 1：
1：- 6 behenate of -6 stearate of polyglycereol and polyglycereol, trade name TEGO Care PBS 6 create moral by winning
Gu Sai companies provide；
2：The smooth stearate of sorb and the smooth laurate of sorb, trade name Arlacel LC, by standing grain, major company provides；
3：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers, trade name PemulenTR-2, by road
Bo Run companies provide；
4:Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers, trade name CarbopolUltrez
21, it is provided by Lubrizol Corp.；
5：Xanthans, trade name KELTROL CG-SFT can company's offer by Si Bikai；
6:Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate and saualane and polysorbate -60, trade name
SIMULGEL NS are provided by matching BIC Corp；
7：Microcrystalline cellulose and cellulose gum, trade name MOISPRAY C, are provided by DAITO KASEI；
8：Ammonium acryloyldime-thyltaurate/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers, trade name
Aristoflex BLV, are provided by Clariant Corporation；
9：Ammonium acryloyldime-thyltaurate/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers, trade name
Aristoflex HMB, are provided by Clariant Corporation；
10：Acrylic acid (ester) analog copolymer (45% aqueous solution), trade name ERMACRYL AQFPolymer, by Acker
Nobel company of Soviet Union provides；
11：VP/ hexadecene copolymers, trade name Antaron V-216, are provided by Ya Shilan companies；
12：VP/ eicosene copolymers, trade name Antaron V-220, are provided by Ya Shilan companies；
13：Two heptanoate of polyester -7 and neopentyl glycol, trade name LEXFILM SUN are provided by INOLEX companies.
Comparative example 1-6
Comparative example 1-6 provides a kind of composition for mosquito repellent respectively, the composition of comparative example 1-6 respectively with embodiment 1-
6 composition one-to-one correspondence compares, i.e. comparative example 1 compared with embodiment 1, comparative example 2 compared with embodiment 2, and so on.It is right
Each component and dosage are become compared with the composition of corresponding embodiment in the dosage of grease in the composition of ratio 1-6
Change, other components and dosage are consistent with corresponding embodiment composition.It is as follows as the component of grease and dosage in comparative example 1-6
Shown in table 2.
As the component and dosage (wt.%) of grease in the composition of 2 comparative example 1-6 of table
| Comparative example | 1 | 2 | 3 | 4 | 5 | 6 |
| Corresponding embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
| Isopropyl palmitate | 0 | 0 | 0 | 6 | 0 | 10 |
| Hexyl decyl alcohol | 0 | 2 | 0 | 0 | 0 | 0 |
| Isooctadecanol | 0 | 2 | 0 | 0 | 0 | 5 |
| Octyl dodecanol | 0 | 0 | 0 | 0 | 0 | 5 |
| Sad Propylheptyl | 0 | 0 | 0 | 0 | 6 | 0 |
| Carbonic acid ethylhexanoate | 0 | 0 | 5 | 6 | 0 | 0 |
Comparative example 7-12
Comparative example 7-12 provides a kind of composition for mosquito repellent respectively, the composition of comparative example 7-12 respectively with embodiment
1-6 composition one-to-one correspondence compares, i.e. comparative example 7 compared with embodiment 1, comparative example 8 compared with embodiment 2, and so on.
Each component and dosage are compared with the composition of corresponding embodiment in the composition of comparative example 7-12, in the composition of comparative example 7-12
Corresponding water resistant film forming agent is not used, other components and dosage are consistent with corresponding embodiment composition.
Comparative example 13
Comparative example 13 provides a kind of composition for mosquito repellent, and contained component and dosage are as follows in composition, combination
Object is mixed by following each components and is uniformly dispersed and is made：Butanediol 5wt.%, ethyl alcohol 20wt.%, to menthyl -3,8- glycol
6wt.%, Cremophor RH40 10wt.%, Preservative qs, EDETATE SODIUM 0.05wt.%, surplus be deionized water (extremely
100wt.%).The state of the composition of this comparative example is colourless transparent liquid.
Above-described embodiment and appearance, effective protecting time and the water repelling property of comparative example are tested, it is specific as follows.
1, appearance compares
The state of the composition of embodiment 1-6 and comparative example 1-6 at normal temperatures is compared, as shown in table 3 below, with embodiment 1-
6 combination is compared, and the composition of comparative example 1-6 occurs quickly to menthyl -3,8- glycol crystal.
The appearance of table 3 embodiment 1-6 and comparative example 1-6
| Room temperature sample appearance (25 DEG C) | Room temperature sample appearance (25 DEG C) | ||
| Embodiment 1 | Flowable emulsion | Comparative example 1 | Flowable emulsion has crystallization to be precipitated |
| Embodiment 2 | Sprayable emulsion | Comparative example 2 | Sprayable emulsion has crystallization to be precipitated |
| Embodiment 3 | Flowable emulsion | Comparative example 3 | Flowable emulsion has crystallization to be precipitated |
| Embodiment 4 | Do not flow frost | Comparative example 4 | Frost is not flowed, has crystallization to be precipitated |
| Embodiment 5 | Sprayable emulsion | Comparative example 5 | Sprayable emulsion has crystallization to be precipitated |
| Embodiment 6 | Do not flow frost | Comparative example 6 | Frost is not flowed, has crystallization to be precipitated |
2, effective protecting time compares
Comparative example 7-12 eliminates water resistant film forming agent compared with embodiment 1-6, and other components are constant.Comparative example 13 is existing
Use the technology to menthyl -3,8- glycol.According to GB/T 13917.9-2009 agriculture chemical registrations hygienic insecticide indoor harmacological effect
Experiment and the composition progress effective protecting time test for evaluating the composition and comparative example 7-13 to embodiment 1-6.Test side
The material used in method, test method, calculates according to national standard equipment.
Test interval in test method carries out as described below：To menthyl -3,8- glycol in composition
Content is less than or equal to 3%, is once tested every 0.5h；3% is more than to the content of menthyl -3,8- glycol and is less than
It is once tested every 1h between 6%；6% is more than to the content of menthyl -3,8- glycol, 2h is smeared and carries out first time survey
Examination, is once tested every 1h later.
Test result is as follows shown in table 4, and the effective protecting time of the composition of embodiment 1-6 is longer than as can be seen from the table
The composition of comparative example 7-13 illustrates active ingredient can be made to menthyl -3,8- bis- using water resistant film forming agent of the present invention
The residence time of alcohol on the skin is elongated, and the mosquito-proof time is promoted.Identical to menthyl 3, under the concentration of 8- glycol, embodiment
Guard time of the composition of 4-5 and comparative example 10-11 than the composition of comparative example 13 is long, illustrates the guarantor of this compound composition
The existing formula technique of comparative example 13 will be significantly better than by protecting effect, and the present composition can make to menthyl -3,8- glycol
Effect plays more preferably.
The effective protecting time of the composition of 4 embodiment 1-6 of table and the composition of comparative example 7-13
| Effective protecting time (h) | |
| Embodiment 1 | 1 |
| Embodiment 2 | 1.5 |
| Embodiment 3 | 3.25 |
| Embodiment 4 | 3.75 |
| Embodiment 5 | 4 |
| Embodiment 6 | 6 |
| Comparative example 7 | 0.875 |
| Comparative example 8 | 1.25 |
| Comparative example 9 | 2.75 |
| Comparative example 10 | 3 |
| Comparative example 11 | 3 |
| Comparative example 12 | 5.25 |
| Comparative example 13 | 2 |
3, water repelling property compares
Comparative example 13 and identical to the content of menthyl -3,8- glycol in the composition of embodiment 4, formula system difference,
It is traditional technology and inventive formulation technology respectively.It is tester that test, which starts the preceding method according to GB/T 13917.9-2009,
Member's spread compositions, start timing after smearing, after object to be combined rests on skin surface 15 minutes, subject's both hands are put into
5 minutes (noticing that the back of the hand is upward, water floods the back of the hand) is impregnated in water, is discharged to wait for for 20 minutes and is dried and (do not wiped with towel), from
Timing starts to be tested according to GB/T 13917.9-2009 every 1h.Test result is as follows shown in table 5, in terms of test result,
Protection efficiency of the composition of the comparative example 13 of traditional technology after meeting water is greatly reduced, but the implementation of inventive formulation technology
The composition of example 4 remains to be kept for the longer mosquito-proof time after aqueous workup.Thus illustrate that composition of the present invention can be more preferable
Performance to the mosquito-proof effect of menthyl -3,8- glycol, and have the ability for resisting moisture interference.
The water repelling property test result of the composition of 5 embodiment 4 of table and comparative example 13
It is described above only with embodiment come the technology contents that further illustrate the present invention, in order to which reader is easier to understand,
But embodiments of the present invention are not represented and are only limitted to this, any technology done according to the present invention extends or recreation, is sent out by this
Bright protection.
Claims (10)
1. one kind can be promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, which is characterized in that contain following matter
Measure each component of percentage：
2-10% to menthyl -3,8- glycol,
The grease of 4-40%,
The emulsifier of 0.5-10%,
The rheology modifier of 0.15-3%,
The water resistant film forming agent of 0.3-3%,
The 1,3-BDO of 5-10%,
Surplus is water.
2. according to claim 1 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the grease is (2-4) with the mass ratio to menthyl -3,8- glycol:1.
3. according to claim 1 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the grease is the polarity grease that fusing point is less than 0 DEG C.
4. according to claim 3 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the grease is selected from carbonic acid ethylhexanoate, hexyl decyl alcohol, octyl dodecanol, isooctadecanol, myristic acid isopropyl
At least one of ester, sad Propylheptyl, Dermol 105.
5. according to claim 1 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the emulsifier is selected from polysorbate esters, alkyl glucosides glycoside, alkyl sucrose esters, glyceride type, alkanol polyoxy second
Alkene ethers, polyoxyethylated alkyl esters, the smooth alkyl esters of sorb, polyglycereol alkyl esters, alkanol phosphoric acid ester and they
At least one of salt.
6. according to claim 1 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the rheology modifier is selected from least one of hydrophilic gel, hydrophilic and oleophilic gelling agent.
7. according to claim 6 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the rheology modifier is selected from xanthans, aluminum magnesium silicate, lithium metasilicate magnesium, microcrystalline cellulose, cellulose gum, montmorillonite, third
Olefin(e) acid hydroxyl ethyl ester/sodium acryloyldimethyl taurate copolymers, ammonium acryloyl taurate/VP copolymer, acryloyl two
N-methyltaurine ammonium/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers, polyacrylate cross-linked polymer -6, propylene
Sour (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, acrylic acid (ester) class/- 25 methacrylate of docosyl alcohol polyethers
At least one of copolymer.
8. according to claim 1 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the water resistant film forming agent is selected from alkyl vinyl pyrrolidinone copolymer, polyesters, acrylic acid (ester) analog copolymer, propylene
One kind in sour (ester)/octylacrylamido.
9. according to claim 8 promoted to menthyl -3,8- glycol effect without the mosquito-proof composition of ethyl alcohol, feature
It is, the water resistant film forming agent is selected from VP/ hexadecene copolymers, VP/ eicosene copolymers, polyester -7, acrylic acid (ester)
One kind in analog copolymer, acrylic acid (ester)/octylacrylamido.
10. can be promoted to menthyl -3,8- glycol effects without the mosquito-proof combination of ethyl alcohol according to claim 1-9 any one of them
Object, which is characterized in that composition is sprayable dosage form, flowable dosage form or not flowable formulation.
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| CN111264570A (en) * | 2020-03-10 | 2020-06-12 | 中山榄菊日化实业有限公司 | Plant mosquito-repellent incense and preparation method thereof |
| CN112043612A (en) * | 2020-08-19 | 2020-12-08 | 广州市浪奇实业股份有限公司 | Low-sensitivity mosquito-proof composition without organic solvent |
| CN112089635A (en) * | 2020-08-19 | 2020-12-18 | 广州市浪奇实业股份有限公司 | Organic solvent-free anti-mosquito composition from food additive source |
| CN112618438A (en) * | 2020-12-31 | 2021-04-09 | 乐比(广州)健康产业有限公司 | Mosquito repelling composition suitable for children and preparation method and application thereof |
| CN116270322A (en) * | 2023-03-21 | 2023-06-23 | 常州胜杰生命科技股份有限公司 | Mosquito repellent product containing menthanediol and preparation and application methods thereof |
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