CN112043612A - Low-sensitivity mosquito-proof composition without organic solvent - Google Patents
Low-sensitivity mosquito-proof composition without organic solvent Download PDFInfo
- Publication number
- CN112043612A CN112043612A CN202010837939.9A CN202010837939A CN112043612A CN 112043612 A CN112043612 A CN 112043612A CN 202010837939 A CN202010837939 A CN 202010837939A CN 112043612 A CN112043612 A CN 112043612A
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- Prior art keywords
- mosquito
- emulsifier
- low
- sensitivity
- oil
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 239000003960 organic solvent Substances 0.000 title claims abstract description 18
- 239000000077 insect repellent Substances 0.000 claims abstract description 39
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 28
- LMXFTMYMHGYJEI-UHFFFAOYSA-N Menthoglycol Natural products CC1CCC(C(C)(C)O)C(O)C1 LMXFTMYMHGYJEI-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000007957 coemulsifier Substances 0.000 claims abstract description 16
- 239000006254 rheological additive Substances 0.000 claims abstract description 11
- 239000004519 grease Substances 0.000 claims abstract description 10
- 230000001442 anti-mosquito Effects 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 125000005456 glyceride group Chemical group 0.000 claims description 21
- 239000003921 oil Substances 0.000 claims description 18
- 235000019198 oils Nutrition 0.000 claims description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000341 volatile oil Substances 0.000 claims description 15
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 12
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid ester group Chemical group C(CCCCCCCCCCC)(=O)O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 12
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims description 12
- 241000196324 Embryophyta Species 0.000 claims description 9
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 claims description 6
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 235000021357 Behenic acid Nutrition 0.000 claims description 6
- 239000005639 Lauric acid Substances 0.000 claims description 6
- 229940116226 behenic acid Drugs 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims description 5
- 229940078812 myristyl myristate Drugs 0.000 claims description 5
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 claims description 5
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000010642 eucalyptus oil Substances 0.000 claims description 4
- 229940044949 eucalyptus oil Drugs 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 3
- MWEOKSUOWKDVIK-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCCOCCOCCOCCOCCOCCOCCO MWEOKSUOWKDVIK-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 3
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 3
- 244000178870 Lavandula angustifolia Species 0.000 claims description 3
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 3
- 240000003553 Leptospermum scoparium Species 0.000 claims description 3
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 3
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 3
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 claims description 3
- FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 claims description 3
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 229940073639 ceteareth-6 Drugs 0.000 claims description 3
- 229940056318 ceteth-20 Drugs 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- 239000001941 cymbopogon citratus dc and cymbopogon flexuosus oil Substances 0.000 claims description 3
- 239000001102 lavandula vera Substances 0.000 claims description 3
- 235000018219 lavender Nutrition 0.000 claims description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 3
- 229940077414 peg-12 stearate Drugs 0.000 claims description 3
- 229940032067 peg-20 stearate Drugs 0.000 claims description 3
- 229940032041 peg-8 laurate Drugs 0.000 claims description 3
- 235000019477 peppermint oil Nutrition 0.000 claims description 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 3
- 229940113124 polysorbate 60 Drugs 0.000 claims description 3
- 229940057429 sorbitan isostearate Drugs 0.000 claims description 3
- 229950011392 sorbitan stearate Drugs 0.000 claims description 3
- 229940098760 steareth-2 Drugs 0.000 claims description 3
- 229940100459 steareth-20 Drugs 0.000 claims description 3
- 229940100458 steareth-21 Drugs 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 claims 3
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims 2
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 229940110830 beheneth-25 methacrylate Drugs 0.000 claims 1
- 229940049290 hydrogenated coco-glycerides Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 24
- 229930006948 p-menthane-3,8-diol Natural products 0.000 abstract description 15
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 230000000172 allergic effect Effects 0.000 abstract description 5
- 208000030961 allergic reaction Diseases 0.000 abstract description 5
- 208000010668 atopic eczema Diseases 0.000 abstract description 5
- 150000005846 sugar alcohols Polymers 0.000 abstract description 4
- 235000013373 food additive Nutrition 0.000 abstract description 3
- 239000002778 food additive Substances 0.000 abstract description 3
- 230000003266 anti-allergic effect Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 20
- 241000255925 Diptera Species 0.000 description 17
- 235000013350 formula milk Nutrition 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 241000238631 Hexapoda Species 0.000 description 6
- 230000001846 repelling effect Effects 0.000 description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 4
- -1 glyceryl myristate citrate Chemical compound 0.000 description 4
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 4
- 229940104261 taurate Drugs 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000575 pesticide Substances 0.000 description 3
- 244000165852 Eucalyptus citriodora Species 0.000 description 2
- 235000004722 Eucalyptus citriodora Nutrition 0.000 description 2
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229960001673 diethyltoluamide Drugs 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000005871 repellent Substances 0.000 description 2
- 230000002940 repellent Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- UTZAAOLGAKMJTB-UHFFFAOYSA-N 2,3-dihydroxypropyl docosanoate 2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound C(CCCCCCCCCCCCCCCCCCCCC)(=O)OCC(O)CO.C(CC(O)(C(=O)O)CC(=O)O)(=O)O UTZAAOLGAKMJTB-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 241000256173 Aedes albopictus Species 0.000 description 1
- DXTYUKURIDYPBL-UHFFFAOYSA-N C(C(O)C)(=O)O.C(CCCCCCCCCCCCC)(=O)OCC(O)CO Chemical compound C(C(O)C)(=O)O.C(CCCCCCCCCCCCC)(=O)OCC(O)CO DXTYUKURIDYPBL-UHFFFAOYSA-N 0.000 description 1
- YRJNQMXQXYPHFY-UHFFFAOYSA-N CC(O)C(O)=O.CCCCCCCCCCCC(=O)OCC(O)CO Chemical compound CC(O)C(O)=O.CCCCCCCCCCCC(=O)OCC(O)CO YRJNQMXQXYPHFY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 241000258963 Diplopoda Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 241001674048 Phthiraptera Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- HFJHNGKIVAKCIW-UHFFFAOYSA-N Stearyl monoglyceridyl citrate Chemical compound OCC(O)CO.OC(=O)CC(O)(CC(O)=O)CC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O HFJHNGKIVAKCIW-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a low-sensitivity mosquito-proof composition without an organic solvent, which comprises the following components in percentage by mass: 4-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water. The anti-allergy raw material adopted by the invention is a food additive, so that the safety of the formula is greatly improved, and the stability of the p-menthane-3,8-diol can be improved. The composition does not contain ethanol, can avoid the damage to skin caused by excessive ethanol, and can greatly reduce the allergic reaction of allergic people to the menthane-3, 8-diol. The anti-mosquito composition solves the dependence of p-menthane-3,8-diol on ethanol or polyalcohol when a formula is used, and simultaneously solves the problems that the p-menthane-3,8-diol is not uniformly spread on the surface of skin and is easily interfered by moisture. Therefore, the mosquito-repellent composition can improve the mosquito-repellent effect and prolong the mosquito-repellent duration.
Description
Technical Field
The invention relates to the technical field of daily chemical industry, in particular to a low-sensitivity mosquito-proof composition without organic solvent.
Background
Insect repellents are a revolution in the use of insecticides. The repellent can be applied to the skin to protect the skin from the biting of mosquitoes, mites, lice, and insects. With the increasing problem of resistance to insecticides and the increasing demand for safety of pesticides, the market needs new, safer active ingredients to replace existing compounds.
P-menthane-3,8-diol, also known as p
-3,8-diol or Menthanediol, known by the english name p-Menthane-3,8-diol, Menthanediol, PMD for short. PMD is an active ingredient for mosquito repellents, specifically with a parellel odor similar to that of menthol, which makes people feel cool, and consists of 8 isomers, generally regarded as a mixture of isomers. PMD is the only natural active ingredient of insect repellents permitted in the united states and european union, and is useful as an insect repellent for mosquitoes, rhinorrhea, millipedes, and the like, with long effective times. When the compound is used as a mosquito repellent, the PMD and the DEET have the same mosquito repelling effect when used in the same amount, and the toxicity is only one sixth of that of the DEET.
The p-menthane-3,8-diol is in crystal form at normal temperature, and the melting point is higher than the skin temperature. At present, mosquito repellent products using p-menthane-3,8-diol as a main component in the market are prepared by using ethanol, polyhydric alcohol and other organic solvents to compound surfactants to solubilize the p-menthane-3,8-diol, and although the stable products of the p-menthane-3,8-diol can be obtained in the combination form, the ethanol is used as a solvent, the mosquito repellent effect is reduced and the effective time is shortened after the ethanol is volatilized; the polyhydric alcohol is used as a solvent, and a large amount of organic solvent is introduced into the formula, so that the formula cost is increased. Part of people have sensitization to mosquito repellent containing p-menthane-3,8-diol when the dosage is large.
Disclosure of Invention
In order to solve the disadvantages and shortcomings of the prior art, the invention provides a low-sensitivity mosquito-repellent composition without organic solvent.
The technical scheme adopted by the invention is as follows:
the low-sensitivity mosquito-repellent composition does not contain an organic solvent, and comprises the following components in percentage by mass: 4-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water.
Preferably, the mosquito-proof composition comprises the following components in percentage by mass: 8-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water.
Further, the oil is synthetic oil or a mixture of synthetic oil and plant essential oil.
Further, the synthetic oil is at least one of caprylic/capric glyceride, dioctyl carbonate, hydrogenated coconut oil glyceride, hydrogenated polydecene, myristyl myristate and C12-15 alcohol benzoate.
The caprylic/capric acid Glyceride (GTCC), the dicaprylyl carbonate (CC), the hydrogenated coconut oil glyceride (Sofitisan100), the hydrogenated polydecene, the Myristyl Myristate (MM) and the C12-15 Alcohol Benzoate (AB) are all easy-spreading and refreshing grease, and are suitable for being used in summer.
Further, the plant essential oil is at least one of eucalyptus citriodora oil, peppermint oil, tea tree essential oil, lemongrass oil, eucalyptus oil and lavender essential oil, and the addition amount of the plant essential oil is less than 50% of the total mass of the oil.
Further, the emulsifier is a high HLB and low HLB compounded emulsifier.
Specifically, the low HLB emulsifier is an emulsifier with HLB of 2.0-10.0, and comprises at least one of steareth-2, sucrose distearate, sorbitan stearate, sorbitan isostearate and ceteareth-6.
Specifically, the high HLB emulsifier is an emulsifier with HLB of 12.0-17.0, and comprises at least one of polysorbate-60, sucrose stearate, steareth-20, steareth-21, ceteth-20, ceteth-25, PEG-8 laurate, PEG-12 stearate, PEG-20 stearate and polyglycerol-3-methylglucose distearate.
Furthermore, the ratio of the high HLB emulsifier to the low HLB emulsifier is 2: 1-1: 2.
Further, the coemulsifier is glyceride, and the structural formula is as follows:
wherein one of R1, R2 and R3 is lactic acid or citric acid, the other is lauric acid, myristic acid, arachidic acid or behenic acid, and the third group is H, citric acid, lactic acid, lauric acid, myristic acid, arachidic acid or behenic acid; the coemulsifier is a mixture of one or more glycerides.
The lactic acid fatty glyceride and the citric acid fatty glyceride are common food additives, wherein the maximum dosage of the lactic acid fatty glyceride in the cream is 5g/kg, and the maximum dosage of the citric acid fatty glyceride in the infant formula food is 24g/kg, so that the glyceride for the co-emulsifier is safe in dosage of 0.1-0.5%, and does not cause risks to users. Cosmetically acceptable similar glycerides are hydrogenated vegetable oil glycerides citrate, hydrogenated palm oil glycerides citrate, hydrogenated tallow glycerides citrate, glycerol stearate citrate, glycerol oleate citrate, which are not cosmetically acceptable glycerides in the present invention. The addition of a co-emulsifier has an unexpected effect on reducing the allergic reaction to menthane-3, 8-diol.
Further, the rheology modifier is at least one of carbomer, acryloyl dimethyl ammonium taurate/VP copolymer (trade name AristofolexAVC), acryloyl dimethyl ammonium taurate/behenyl alcohol polyether-25-methacrylate copolymer (trade name AristofolxBLV) and acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer (trade name carbopol Ultrez 21, carbopol Ultrez 20, Pemulen TR-1, Pemulen TR-2, Pemulen EZ-4U).
The water phase of the rheology modifier in the composition in an aqueous environment can disperse, stabilize, emulsify or suspend oil phase components, so that the oil phase components are more stable and can not be separated out.
Compared with the prior art, the invention has the advantages that:
1. the anti-allergy raw material adopted by the invention is a food additive, so that the safety of the formula is greatly improved, and the stability of the p-menthane-3,8-diol can be improved.
2. The composition does not contain ethanol, can avoid the damage to skin caused by excessive ethanol, can also avoid the influence on the mosquito-proof effect caused by the crystallization and precipitation of p-menthane-3,8-diol, and can greatly reduce the allergic reaction of allergic people to the p-menthane-3,8-diol by the formula of the mosquito-proof composition.
3. According to the invention, through adding other components such as oil and fat in a certain proportion and matching with the p-menthane-3,8-diol, the anti-mosquito active component can be better applied to an anti-mosquito product, the maximum effect is exerted, the dependence of the p-menthane-3,8-diol on ethanol or polyhydric alcohol during formula use is solved, and the problems that the p-menthane-3,8-diol is uneven in spreading on the surface of the skin and is easily interfered by moisture are solved. Therefore, the mosquito-repellent composition can improve the mosquito-repellent effect and prolong the mosquito-repellent duration.
Detailed Description
All materials, reagents and equipment selected for use in the present invention are well known in the art, but do not limit the practice of the invention, and other reagents and equipment well known in the art may be suitable for use in the practice of the following embodiments of the invention.
Examples
The low-sensitivity mosquito-repellent composition does not contain an organic solvent, and comprises the following components in percentage by mass: 4-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water.
Preferably, the mosquito-proof composition comprises the following components in percentage by mass: 8-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water.
Specifically, the oil is synthetic oil or a mixture of synthetic oil and plant essential oil; the synthetic grease is at least one of caprylic/capric glyceride, dioctyl carbonate, hydrogenated coconut oil glyceride, hydrogenated polydecene, myristyl myristate and C12-15 alcohol benzoate; the plant essential oil is at least one of eucalyptus citriodora oil, peppermint oil, tea tree essential oil, lemongrass oil, eucalyptus oil and lavender essential oil, and the addition amount of the plant essential oil is less than 50% of the total mass of the grease.
Specifically, the emulsifier is a high HLB and low HLB compounded emulsifier, and the ratio of the high HLB to the low HLB is 2: 1-1: 2; the low HLB emulsifier is an emulsifier with HLB of 2.0-10.0, and comprises at least one of steareth-2, sucrose distearate, sorbitan stearate, sorbitan isostearate and ceteareth-6; the high HLB emulsifier is an emulsifier with HLB of 12.0-17.0, and comprises at least one of polysorbate-60, sucrose stearate, steareth-20, steareth-21, ceteth-20, ceteth-25, PEG-8 laurate, PEG-12 stearate, PEG-20 stearate and polyglycerol-3-methylglucdistearate.
Specifically, the coemulsifier is glyceride, and the structural formula is as follows:
wherein one of R1, R2 and R3 is lactic acid or citric acid, the other is lauric acid, myristic acid, arachidic acid or behenic acid, and the third group is H, citric acid, lactic acid, lauric acid, myristic acid, arachidic acid or behenic acid; the coemulsifier is a mixture of one or more glycerides.
Specifically, the rheology modifier is at least one of carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, acryloyl dimethyl ammonium taurate/behenyl polyether-25-methacrylate copolymer and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer.
The invention will be illustrated by examples 1 to 14, while the mosquito repellent composition of each example is subjected to a mosquito repellent effect test, a freeze-thaw stability test and an allergy test.
Specifically, the mosquito repellent effect test method comprises the following steps: selecting 8 or more qualified testers (half of male and female, no need for drinking wine, tea or coffee before and during the test, no need for essence-containing product), and drawing skin area of 50mm × 50mm on back of each hand, wherein one hand is pressed at a rate of 1.5mg/cm2The dosage of the mosquito repellent is uniformly smeared on a mosquito repellent to be detected, the skin with the thickness of 40mm multiplied by 40mm is exposed, the rest part is closely shielded, and the other hand is used as a blank control. Smearing mosquito repellent for 2h, putting hands into mosquito cage with qualified attack power for 2min, and observing whether there is mosquito coming and falling before and sucking blood. And then testing every 1h, and judging that the mosquito repellent is invalid as long as one mosquito sucks blood in front of the mosquito.The effective protection time (h) of the mosquito repellent was recorded. The contrast test is firstly carried out by the contrast hand each time, the test insects with qualified attack force can be continuously tested, and the test insects with qualified attack force need to be replaced for testing if the attack force is unqualified.
The specific method of the attack force test comprises the following steps: 300 Aedes albopictus (female mosquito) were placed in a 400mm x 300mm mosquito cage, and the back of the hand was exposed to 40mm x 40mm skin, with the remainder tightly covered. The hands are put into the mosquito cage for 2min, the mosquitoes are closely observed to stay, the hands shake the arms to drive the mosquitoes away before the mouth organ pierces the skin, and the number of the tested insects is recorded as 1. More than 30 test persons who stop before and have the test insects fall off before and the test insects have qualified offensive power, and the persons and the mosquitoes in the cage can be subjected to repellent tests.
And (3) testing the freeze-thaw stability: the anti-mosquito composition of each embodiment is frozen for 24 hours at-15 to-25 ℃, then placed at room temperature for unfreezing, and the product is observed whether the phenomena of unevenness, delamination, thinning and the like exist, and then the processes are carried out for 7 cycles.
And (3) allergic reaction test: the anti-mosquito composition is directly smeared on the arms of volunteers to observe whether allergic phenomena such as redness, swelling (spots), pruritus and the like occur, each embodiment needs 20 people for skin test, and the number of allergic people is counted.
The concrete components and the added mass percentages of the examples 1 to 14 are shown in the following table:
table continuation:
the test results show that the mosquito-repellent composition samples in examples 1-14 are all stable after repeated freeze thawing; except for the individual examples, the mosquito repellent has good mosquito repellent effect; none of the samples tested exhibited symptoms of allergy.
Comparative example
An anti-mosquito composition having similar composition to the above examples except that no co-emulsifier (glyceryl laurate lactate, glyceryl myristate citrate, glyceryl myristate lactate, glyceryl arachinate lactate, glyceryl behenate citrate, glyceryl laurate myristate lactate and/or glyceryl arachinate citrate) is added.
The following will be illustrated by comparative examples 1 to 11, and the mosquito-repellent composition of each example was subjected to the mosquito-repellent effect test, the freeze-thaw stability test and the allergy test in the same manner as in the above examples.
The specific components and the addition mass percentages of the comparative examples 1 to 11 are shown in the following table:
table continuation:
according to the test results, only individual samples of the mosquito-proof composition samples in the comparative examples 1 to 11 are stable after repeated freeze thawing; under the condition of the same content of active ingredients (p-menthane-3, 8-diol), the mosquito repelling time of the comparative example samples is lower than that of the examples, which indicates that the mosquito repelling effect is not as good as that of the examples; when the content of the active ingredient (p-menthane-3, 8-diol) was 8%, some of the comparative examples exhibited allergic reactions, when the content of the active ingredient (p-menthane-3, 8-diol) reached 10%, all of the comparative examples exhibited allergic reactions, and when the content of the active ingredient (p-menthane-3, 8-diol) reached 10%, all of the examples exhibited no allergic reactions.
In conclusion, the anti-mosquito composition disclosed by the invention is high in stability, greatly reduces the allergic reaction of allergic people to the menthane-3,8-diol, and is good in mosquito repelling effect and long in mosquito repelling time; the invention is a non-pesticide mosquito repellent, but part of samples even reach the standard of pesticides.
The present invention is not limited to the above-described embodiments, and various modifications and variations of the present invention are intended to be included within the scope of the claims and the equivalent technology of the present invention if they do not depart from the spirit and scope of the present invention.
Claims (10)
1. The low-sensitivity mosquito-repellent composition without organic solvent is characterized by comprising the following components in percentage by mass: 4-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water.
2. The low-sensitivity mosquito-repellent composition free of organic solvent according to claim 1, characterized by comprising the following components in percentage by mass: 8-10% of p-menthane-3,8-diol, 10-16% of grease, 2-5% of an emulsifier, 0.1-0.5% of a co-emulsifier, 0.2-0.5% of a rheology modifier, 0-0.1% of a pH regulator and the balance of water.
3. The low-sensitivity and mosquito-repellent composition free of organic solvent according to claim 1 or 2, wherein the oil is synthetic oil or a mixture of synthetic oil and plant essential oil.
4. An organic solvent-free low sensitivity anti-mosquito composition according to claim 3, wherein the synthetic oil is at least one of caprylic/capric acid glyceride, dicaprylyl carbonate, hydrogenated cocoglycerides, hydrogenated polydecene, myristyl myristate and C12-15 alcohol benzoate.
5. The low-sensitivity and mosquito-repellent composition free of organic solvents according to claim 3, wherein the plant essential oil is at least one of lemon eucalyptus oil, peppermint oil, tea tree essential oil, lemongrass oil, eucalyptus oil and lavender essential oil, and the amount of the plant essential oil added is less than 50% of the total mass of the oil.
6. The low-sensitivity and mosquito-repellent composition free of organic solvents according to claim 1 or 2, wherein the emulsifier is a high HLB and low HLB compounded emulsifier.
7. An organic solvent free low sensitivity anti-mosquito composition according to claim 6 wherein the low HLB emulsifier is an emulsifier having an HLB of 2.0 to 10.0 and comprises at least one of steareth-2, sucrose distearate, sorbitan stearate, sorbitan isostearate and ceteareth-6; the high HLB emulsifier is an emulsifier with HLB of 12.0-17.0, and comprises at least one of polysorbate-60, sucrose stearate, steareth-20, steareth-21, ceteth-20, ceteth-25, PEG-8 laurate, PEG-12 stearate, PEG-20 stearate and polyglycerol-3-methylglucdistearate.
8. The low-sensitivity and mosquito-repellent composition free of organic solvents according to claim 6, wherein the ratio of the emulsifier compounded with high HLB and low HLB is 2: 1-1: 2.
9. The low-sensitivity and mosquito-repellent composition free of organic solvent according to claim 1 or 2, wherein the co-emulsifier is a glyceride having a structural formula:
wherein one of R1, R2 and R3 is lactic acid or citric acid, the other is lauric acid, myristic acid, arachidic acid or behenic acid, and the third group is H, citric acid, lactic acid, lauric acid, myristic acid, arachidic acid or behenic acid; the coemulsifier is a mixture of one or more glycerides.
10. The low sensitivity, mosquito repellent composition without organic solvent according to claim 1 or 2, wherein said rheology modifier is at least one of carbomer, ammonium acryloyldimethyltaurate/VP copolymer, ammonium acryloyldimethyltaurate/beheneth-25-methacrylate copolymer and acrylic acid/C10-30 alkanol acrylate crosspolymer.
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