JP6960471B2 - Gel-type pest repellent for humans - Google Patents

Description

The present invention relates to a water-soluble gel-type pest repellent for humans.

Conventionally, the aerosol type, which is easy to use, has been the mainstream as a pest repellent for the human body, but since the pest repellent component is made into fine particles and sprayed on the skin surface, some users may feel irritation to the nasal mucosa. .. In addition, with aerosol-type pest repellents for humans, there are cases where uneven coating occurs on the coated surface and there are areas where the pest repellent component does not adhere, and mosquitoes and other biting pests sensitively detect these small areas. Causes blood-sucking behavior. Therefore, a gel-type pest repellent that has no uneven coating and does not easily scatter pest repellent components is used.

For example, a gel-like pest repellent composition for the human body containing a pest repellent component, a gel base, and water has been developed (see, for example, Patent Document 1). The gel-like pest repellent composition for human body of Patent Document 1 contains glycol together with a brightener as a skin adhesion indicator of a pest repellent component.

Japanese Unexamined Patent Publication No. 2007-39342

When applying a gel-type pest repellent for humans to the skin, the contents should be applied to the skin such as arms and legs after the contents are placed on the palm, or after the contents are discharged to a part of the skin such as arms and legs. It should be spread over the entire surface of the skin with the palm of your hand. Therefore, at the time of use, the pest repellent for human body adheres not only to the arms and legs but also to the palm. The gel-type pest repellent for humans is expected to be used outdoors where the hands cannot be washed immediately after application, but the user feels inconvenienced by the feeling of stickiness on the palm during outdoor activities, and the user is a gel-type pest repellent. There is a risk of hesitating to apply a pest repellent for the human body. In this regard, the gel-like pest repellent composition for human body of Patent Document 1 improves the visibility of the applied state by blending a skin adhesion indicator, and does not take into consideration the sticky feeling of the palm due to the application. No.

The present invention has been made in view of the above problems, and an object of the present invention is to provide a gel-type pest repellent for humans that can reduce inconvenience caused by the sticky feeling of the palm associated with application. do.

The characteristic composition of the gel type pest repellent for human body according to the present invention for solving the above problems is as follows.
A water-soluble gel-type pest repellent for humans
Contains a gel base, a gelling agent, a pest repellent component, an ultraviolet deterioration suppressing component, and water.
The pest repellent components are 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-. At least one selected from the group consisting of 3,8-diols
The ultraviolet deterioration inhibitory component is ethylhexyl paramethoxycinnamate.

According to the gel-type human pest repellent having this configuration, the sustainability of the pest repellent effect is superior to that of DEET, which has been used as a pest repellent component in the conventional gel-type human pest repellent 2- (2). -Hydroxyethyl) -1-piperidin Carboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-3,8-diol selected from the group Since at least one of the esters is used, it is possible to reduce the number of recoatings in order to maintain the pest repellent effect, and after the coating, it dries in a short time and the sticky feeling can be quickly eliminated. Furthermore, since it contains ethylhexyl paramethoxycinnamate, which has high ultraviolet absorption, as an ultraviolet deterioration suppressing component, it suppresses the deterioration of the pest repellent component due to exposure to ultraviolet rays even when used in the summer when the amount of ultraviolet rays is large. Therefore, the sustainability of the repellent effect can be improved, and frequent repainting can be prevented. As a result, the non-sticky state of the palm can be maintained for a long time, and the inconvenience caused by the sticky feeling of the palm can be reduced. Therefore, the user hesitates to use the gel-type pest repellent for humans in this configuration. Can be used without.

In the gel-type pest repellent for humans according to the present invention,
The content of the pest repellent component is preferably 3 to 20% by weight.

According to the gel-type pest repellent for humans having this composition, by containing the pest repellent component in the above range, the pest repellent effect can be sufficiently maintained, but the pest repellent is dried in a short time after application. , The sticky feeling of the palm can be quickly eliminated.

In the gel-type pest repellent for humans according to the present invention,
The content of the ultraviolet deterioration suppressing component is preferably 0.1 to 1.0% by weight.

According to the gel-type pest repellent for human body of this composition, since the ultraviolet deterioration suppressing component is contained in the above range, the viscosity of the ultraviolet deterioration suppressing component is relaxed, and the pest caused by ultraviolet rays does not cause a sticky feeling at the time of application. Deterioration of the repellent component can be sufficiently suppressed.

In the gel-type pest repellent for humans according to the present invention,
It is preferable to further contain the dispersant of the ultraviolet deterioration suppressing component.

According to the gel-type pest repellent for humans having this configuration, by containing the dispersant of the ultraviolet deterioration suppressing component, even when the ultraviolet deterioration suppressing component is oil-soluble, it can be dispersed in a uniform state.

In the gel-type pest repellent for humans according to the present invention,
The dispersant is preferably ethanol.

According to the gel-type pest repellent for humans having this configuration, by using ethanol as a dispersant, it is possible to impart a refreshing feeling at the time of application and reduce the sticky feeling of the palm.

In the gel-type pest repellent for humans according to the present invention,
It is preferable to further contain a moisturizer.

According to the gel-type pest repellent for humans having this configuration, the inclusion of a moisturizer prevents the pest repellent for humans from drying excessively after application and enhances the adhesion of the pest repellent component to the skin. At the same time, it is possible to give a moist feeling at the time of application and reduce the sticky feeling of the palm.

In the gel-type pest repellent for humans according to the present invention,
The moisturizer is preferably 1,3-butylene glycol and / or seaweed extract.

According to the gel-type pest repellent for humans having the present constitution, by using the above-mentioned substance as a moisturizer, the pest repellent component adheres to the skin and the moist feeling at the time of application becomes excellent.

In the gel-type pest repellent for humans according to the present invention,
It is preferable that the drying time is adjusted to be 10 minutes or less as measured in accordance with JIS K 5600, Part 3, Section 2.

According to the gel-type pest repellent for humans having this configuration, the drying time is adjusted to 10 minutes or less, so that the time from applying the pest repellent for humans to the skin to drying is sufficient. It can be shortened to, and the sticky feeling of the palm can be quickly eliminated.

In the gel-type pest repellent for humans according to the present invention,
It is preferable that the turbidity determined in accordance with the visual method of the 17th revised Japanese Pharmacopoeia / General Test Method 2.61 Turbidity Test Method is adjusted to be less than or equal to the turbidity comparison solution IV.

According to the gel-type pest repellent for humans having this configuration, the turbidity determined according to the visual method of the turbidity test method is adjusted to be equal to or less than the turbidity comparison liquid IV. When applied to the skin, it does not appear white and gives a fresh appearance.

In the gel-type pest repellent for humans according to the present invention,
It is preferable that the viscosity measured according to JIS Z 8803 is adjusted to be 0.5 to 100 Pa · s.

According to the gel-type pest repellent for humans having this composition, it is easy to spread on the skin because the viscosity is adjusted to 0.5 to 100 Pa · s, and the pest repellent component is excellent on the skin. Adhesiveness and malleability can be obtained.

In the gel-type pest repellent for humans according to the present invention,
The viscosity measured in accordance with JIS Z 8803 is adjusted so that the viscosity attenuation rate obtained from the initial viscosity and the final viscosity measured after being left outdoors for one week without shading is 10% or less. Is preferable.

According to the gel-type pest repellent for humans having this configuration, the viscosity attenuation rate is adjusted to 10% or less, so that stable properties are maintained from the initial stage of use to the end of use, which makes it easy to use. It can be an excellent product.

In the gel type pest repellent for human body according to the present invention, it is preferably used for application to the head, face or neck of the human body.

According to the gel-type pest repellent for human body of this composition, the pest repellent component is a gel type that does not easily scatter, and the pest repellent component and the ultraviolet deterioration suppressing component each have relatively mild irritation to the skin 2- A group consisting of (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-3,8-diol. By using at least one selected from and ethylhexyl paramethoxycinnamate, it can be applied not only to the arms and legs of the human body, but also to the head, face, or neck, which are particularly delicate areas. It will be suitable for.

Hereinafter, the gel-type pest repellent for humans of the present invention will be described. However, the present invention is not intended to be limited to the configurations described in the embodiments described below.

[Pest repellent for human body]
The gel-type pest repellent for humans of the present invention is a water-soluble gel-type pest repellent for humans, and contains a gel base, a gelling agent, a pest repellent component, and an ultraviolet deterioration suppressing component. .. The pest repellent component, which is one of the main components of the gel-type pest repellent for humans of the present invention, is 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester [hereinafter referred to as icaridin]. , 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester [hereinafter referred to as IR3535], or p-menthane-3,8-diol. These pest repellent components may be used alone or in combination of two or more. Icaridin, IR3535, and p-menthane-3,8-diol have a longer lasting pest repellent effect than DEET, which is widely used as a pest repellent component in conventional gel-type human pest repellents. .. Therefore, the gel-type pest repellent for humans of the present invention can reduce the number of recoatings in order to maintain the pest repellent effect as compared with the conventional one containing DEET, and it takes a short time after application. To dry. The content of the pest repellent component in the pest repellent for human body of the present invention is preferably 3 to 20% by weight. When the content of the pest repellent component is within such a range, the pest repellent effect can be sufficiently maintained, but the time until drying after application can be sufficiently shortened, and the palm feels sticky. Can be resolved promptly. When the content of the pest repellent component is less than 3% by weight, the pest repellent component adhering to the skin is lost early due to volatilization, and the duration of the pest repellent effect is short. Therefore, it is necessary to frequently reapply the pest repellent for the human body, and each time, a sticky feeling of the palm is generated. If the content of the pest repellent component exceeds 20% by weight, it may take time to dry after application.

Gel-type pest repellents for humans are expected to be used outdoors in the summer when biting pests are likely to appear, but the amount of ultraviolet rays is large in the outdoor environment in the summer. Assuming that the pest repellent component is deteriorated by ultraviolet rays during use, if the pest repellent component for human body is prepared by increasing the content of the pest repellent component, it may take time to dry after application. In addition, it is economically disadvantageous to excessively increase the content of the pest repellent component. Therefore, the gel-type pest repellent for humans of the present invention contains an ultraviolet deterioration suppressing component in order to suppress deterioration of the pest repellent component due to exposure to ultraviolet rays after application. The ultraviolet deterioration suppressing component used in the present invention is ethylhexyl paramethoxycinnamate. Since ethylhexyl paramethoxycinnamate has excellent absorption of ultraviolet rays, it is possible to suppress deterioration of the pest repellent component due to ultraviolet rays and improve the sustainability of the repellent effect by adding it to a pest repellent for humans. Therefore, it is not necessary to excessively increase the content of the pest repellent component, and the number of times of reapplying the human pest repellent to maintain the pest repellent effect in summer use can be reduced. It is possible to prevent repeated sticky feelings on the palm. Further, ethylhexyl paramethoxycinnamate is a transparent liquid, and even if it is blended with a pest repellent for humans, the clarity of the pest repellent for humans is not significantly impaired. As the ultraviolet deterioration suppressing component, it is also possible to use an organic compound having excellent ultraviolet absorption such as a benzophenone derivative such as oxybenzone or a cinnamic acid derivative. Further, not only the organic compound but also inorganic powders such as titanium oxide, zinc oxide, and cerium oxide, which are ultraviolet scattering agents, may be appropriately blended to the extent that the clarity of the pest repellent for human bodies is not impaired.

The content of the ultraviolet deterioration suppressing component in the pest repellent for human body of the present invention is preferably 0.1 to 1.0% by weight. When the content of the ultraviolet deterioration suppressing component is within such a range, the deterioration of the pest repellent component due to ultraviolet rays can be suppressed, and the sustainability of the repellent effect can be sufficiently maintained. As a result, the sustainability of the pest repellent effect and the dryness are well balanced. When the content of the ultraviolet deterioration suppressing component is less than 0.1% by weight, the deterioration of the pest repellent component due to ultraviolet rays cannot be sufficiently suppressed, and the duration of the pest repellent effect becomes short, so that it is frequently performed. It is necessary to reapply the pest repellent for human body, and each time it becomes sticky. When the content of the ultraviolet deterioration suppressing component exceeds 1.0% by weight, the pest repellent component ethylhexyl paramethoxycinnamic acid is oil-soluble and has a viscosity, so that there is a possibility that the sticky feeling at the time of application becomes strong. In addition, the amount of the ultraviolet deterioration suppressing component that is practically necessary is exceeded, which is economically disadvantageous.

The gel base used in the present invention includes a carboxyvinyl polymer, a water-soluble polymer such as polyvinyl alcohol and polyvinylpyrrolidone, an acrylate copolymer, an acrylate / alkyl methacrylate copolymer, and an alkyl acrylate / diacetone acrylamide. Examples thereof include acrylic acid-based polymer compounds such as copolymers, polysaccharides such as alginic acid and salts thereof, and carboxyvinyl polymers are particularly preferable. These gel bases have thixotropy in an aqueous solution and exhibit a sufficient thickening effect even in a small amount. The content of the gel base is preferably 0.05 to 0.5% by weight. When the content of the gel base is within such a range, the pest repellent for humans can be sufficiently viscous, and the pest repellent component can be excellently adhered to the skin and spreadable. If the content of the gel base is less than 0.05% by weight, the viscosity of the pest repellent for humans may be insufficient and it may become difficult to handle. If the content of the gel base exceeds 0.5% by weight, there is a risk that ductility and skin compatibility will deteriorate due to excessive viscosity.

The gelling agent enhances the viscosity of the gel base by adjusting the pH. Examples of the gelling agent used in the present invention include amines such as triethanolamine and tetrahydroxypropylethylenediamine, sodium hydroxide, aminomethylpropanol and the like, and triethanolamine is particularly preferable. The content of the gelling agent in the human pest repellent is adjusted according to the content of the gel base, but is preferably 0.01 to 0.6% by weight. If the content of the gelling agent is less than 0.01% by weight, it may not be possible to sufficiently increase the viscosity of the gel base. If the content of the gelling agent exceeds 0.6% by weight, the thickening of the gel base may be excessively increased, resulting in poor ductility and skin compatibility.

In the present invention, in addition to the above-mentioned components, a dispersant, a moisturizer, an aroma component, etc., which are components for suppressing ultraviolet deterioration, may be appropriately blended. Examples of the dispersant of the ultraviolet deterioration suppressing component include alcohols such as ethanol and isopropanol, and ethanol is particularly preferable. The content of the dispersant is preferably 10 to 50% by weight. When the content of the dispersant is within such a range, the oil-soluble ethylhexyl paramethoxycinnamate can be uniformly dispersed in the pest repellent for humans, and a refreshing feeling at the time of application can be imparted. .. If the content of the dispersant is less than 10% by weight, ethylhexyl paramethoxycinnamate may not be sufficiently dispersed. If the content of the dispersant exceeds 50% by weight, the irritation to the skin may become strong.

Examples of the moisturizing agent include glycols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, diethylene glycol, triethylene glycol, hexylene glycol, and benzyl glycol, seaweed extract, and the like. 1,3-butylene glycol and seaweed extract are preferred. The content of the moisturizer is preferably 0.1 to 10% by weight. When the content of the moisturizer is within such a range, the pest repellent for humans can be prevented from becoming too dry after application, thereby enhancing the adhesion of the pest repellent component to the skin and giving a moist feeling. You can also. If the content of the moisturizer is less than 0.1% by weight, the human pest repellent may be excessively dried after application. If the content of the moisturizer exceeds 10% by weight, it takes time to dry after application, and the sticky feeling of the palm may not be quickly eliminated.

Aroma components include orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, cypress oil, green tea essential oil, limonene, α-pinene, linalol, geraniol, phenylethyl. Examples include aromatic components such as alcohol, amylcinnamic aldehyde, cumin aldehyde, and benzyl acetate, and fragrance components containing green leaf alcohol and green leaf aldehyde called "green scent".

[Dryness]
The drying property of the gel-type pest repellent for humans of the present invention is determined by the surface drying time (hereinafter, simply referred to as "drying time") measured in accordance with Part 3, Section 2 of JIS K 5600. It is preferably prepared so as to take 10 minutes or less. When the drying time is 10 minutes or less, the time from applying the pest repellent for human body to the skin to drying can be sufficiently shortened, and the sticky feeling of the palm can be quickly eliminated. If the drying time exceeds 10 minutes, it takes time to dry after application, and there is a possibility that the sticky feeling of the palm cannot be quickly eliminated.

[Turbidity]
The turbidity of the gel-type pest repellent for humans of the present invention was determined to be "turbidity comparison solution IV or less" in the judgment based on the visual method of the 17th revised Japanese Pharmacopoeia General Test Method 2.61 Turbidity Test Method. It is preferable that the content is 30 NTU or less). If the turbidity is turbidity comparative liquid IV or less (30 NTU or less), whitening does not occur when applied to the skin, and the appearance is fresh. If the turbidity exceeds 30 NTU, there is a risk of whitening when applied to the skin.

[Thixotropy (viscosity)]
The gel-type pest repellent for humans of the present invention is prepared so that the viscosity measured in accordance with JIS Z 8803 (hereinafter, simply referred to as "viscosity") is 0.5 to 100 Pa · s. Is preferable. When the viscosity is in such a range, it is easy to spread on the skin, and excellent adhesion and ductility of the pest repellent component to the skin can be obtained. In particular, the gel-type pest repellent for humans of the present invention has thixotropy property, and the measured value at the time of use after applying the shear stress is higher than the measured value at the time of not using before applying the shear stress. It is preferably prepared to be small. If the measured value in use is smaller than the measured value in use, it can be stored in a stable state in a tube container due to the relatively large viscosity when not in use, and the skin due to the relatively small viscosity when used. It becomes easy to spread on the skin, and excellent adhesion and spreadability of the pest repellent component to the skin can be obtained, so that the balance between good storage stability and ease of spreading during use is excellent.

[Use of pest repellent for human body]
The pest repellent for the human body of the present invention is a gel type in which the pest repellent component is hard to scatter, and the content of the pest repellent component and the ultraviolet deterioration suppressing component is suppressed within the above range, so that the arm of the human body, It can be used not only on the legs, but also on the head, face, or neck, which are particularly delicate areas. In addition, the gel-type pest repellent for humans of the present invention shows a high pest repellent effect against biting pests such as mosquitoes, gnats, abs, ticks, stable flies, bedbugs, bed bugs, biting bugs, and yamabils, and these pests It can be used to prevent bite damage.

[Preparation method]
In the gel-type pest repellent for humans of the present invention, the gel base is dispersed in purified water, and the pest repellent components icaridin, IR3535, and / or p-menthane-3,8-diol are contained in this solution. It is prepared by adding ethylhexyl paramethoxycinnamate, which is an ultraviolet deterioration suppressing component, and mixing, then adding a gelling agent (pH adjuster) and stirring. Further, after adding a dispersant such as ethanol and a moisturizing agent such as 1,3-butylene glycol to a liquid in which a gel base is dispersed in purified water and uniformly dissolving the gel base, a pest repellent component and an ultraviolet deterioration suppressing component are added. By adding a gelling agent, the gel-type pest repellent for humans of the present invention can be easily prepared even when a low-water-soluble organic compound such as ethylhexyl paramethoxycinnamate is used as an ultraviolet deterioration inhibitory component. Can be done.

Since the gel-type pest repellent for humans of the present invention thus obtained contains icaridin, IR3535, and / or p-menthane-3,8-diol as pest repellent components, conventional gel-type pests for humans It has a longer lasting pest repellent effect than DEET, which has been used as a pest repellent component in repellents, and can quickly eliminate the sticky feeling of the palm spread during application. Furthermore, since it contains ethylhexyl paramethoxycinnamate, which has high ultraviolet absorption, as an ultraviolet deterioration suppressing component, it suppresses the deterioration of the pest repellent component due to exposure to ultraviolet rays even when used in the summer when the amount of ultraviolet rays is large. Therefore, the sustainability of the repellent effect can be improved, and frequent repainting can be prevented. As a result, the non-sticky state of the palm can be maintained for a long time, and the inconvenience caused by the sticky feeling of the palm can be reduced. Therefore, the user hesitates to use the gel-type pest repellent for humans of the present invention. Can be used without.

Gel-type pest repellents for humans (Examples 1 to 7) of the present invention were prepared, and their characteristics were measured and evaluated. In addition, gel-type pest repellents for human bodies (Comparative Examples 1 to 4), which are outside the scope of the present invention, were also prepared, and their characteristics were measured and evaluated in the same manner as in Examples.

<Example 1>
According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) was added to purified water as a gel base material, and this was stirred to make a dispersed state, and ethanol (35 parts by weight) was added as a moisturizer. 1,3-butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added, and the mixture was stirred until the liquid became uniform. Then, in this liquid, icaridine (5 parts by weight) as a pest repellent component, ethylhexyl paramethoxycinnamate (0.15 parts by weight) as an ultraviolet deterioration suppressing component, and triethanolamine (0.15 parts by weight) as a gelling agent were added. The mixture was added and stirred until the liquid became a gel to obtain a gel-type pest repellent for humans (100 parts by weight) of Example 1.

<Example 2>
According to the composition of Table 1, the gel type pest repellent for human body of Example 2 was prepared according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (0.9 parts by weight) was added as an ultraviolet deterioration suppressing component. The agent (100 parts by weight) was obtained.

<Example 3>
According to the composition of Table 1, IR3535 (5 parts by weight) was added as a pest repellent component, and ethylhexyl paramethoxycinnamate (0.3 parts by weight) was added as an ultraviolet deterioration suppressing component, according to the same formulation and procedure as in Example 1. A gel-type pest repellent for humans (100 parts by weight) of Example 3 was obtained.

<Example 4>
Example 1 except that p-menthane-3,8-diol (5 parts by weight) was added as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) was added as an ultraviolet deterioration suppressing component according to the composition shown in Table 1. The gel type pest repellent for human body (100 parts by weight) of Example 4 was obtained by the same formulation and procedure as in the above.

<Example 5>
According to the composition of Table 1, the gel type pest repellent for human body of Example 5 was prepared according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (0.05 parts by weight) was added as an ultraviolet deterioration suppressing component. The agent (100 parts by weight) was obtained.

<Example 6>
According to the composition of Table 1, the gel type pest repellent for human body of Example 6 was prepared according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (2.0 parts by weight) was added as an ultraviolet deterioration suppressing component. The agent (100 parts by weight) was obtained.

<Example 7>
According to the composition of Table 1, according to the same formulation and procedure as in Example 1 except that icaridin (20 parts by weight) was added as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) was added as an ultraviolet deterioration suppressing component. A gel-type pest repellent for humans (100 parts by weight) of Example 7 was obtained.

<Comparative example 1>
According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) was added to purified water as a gel base material, and this was stirred to make a dispersed state, and ethanol (35 parts by weight) was added as a moisturizer. 1,3-butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added, and the mixture was stirred until the liquid became uniform. Then, icaridin (5 parts by weight) as a pest repellent component and triethanolamine (0.15 parts by weight) as a gelling agent were added to this liquid, and the mixture was stirred until the liquid became a gel, and compared with Comparative Example 1. A gel-type pest repellent for humans (100 parts by weight) was obtained. The gel-type pest repellent for humans of Comparative Example 1 is a formulation that does not contain an ultraviolet deterioration suppressing component.

<Comparative example 2>
According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) was added to purified water as a gel base material, and this was stirred to make a dispersed state, and ethanol (35 parts by weight) was added as a moisturizer. 1,3-butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added, and the mixture was stirred until the liquid became uniform. Then, in this liquid, Diet (5 parts by weight) as a pest repellent component, ethylhexyl paramethoxycinnamate (0.2 parts by weight) as an ultraviolet deterioration suppressing component, and triethanolamine (0.15 parts by weight) as a gelling agent were added. The mixture was added and stirred until the liquid became a gel to obtain a gel-type pest repellent for humans (100 parts by weight) of Comparative Example 2. The gel-type pest repellent for humans of Comparative Example 2 is a formulation containing the conventionally used DEET as a pest repellent component instead of icaridin, IR3535, or p-menthane-3,8-diol.

<Comparative example 3>
A gel-type pest repellent for humans (100 parts by weight) of Comparative Example 3 according to the same formulation and procedure as in Comparative Example 1 except that icaridin (20 parts by weight) was added as a pest repellent component according to the composition of Table 1. Got

<Comparative example 4>
Gel-type pest repellent for humans (100 parts by weight) of Comparative Example 4 according to the same formulation and procedure as in Comparative Example 1 except that icaridin (30 parts by weight) was added as a pest repellent component according to the composition of Table 1. Got

Samples for the gel-type pest repellents for humans of Examples 1 to 7 and Comparative Examples 1 to 4 were prepared, and the characteristics of the gel-type pest repellents for humans were (1) viscosity attenuation rate and (2). ) Active ingredient recovery rate, (3) drying time, and (4) turbidity were measured. The measuring method of each characteristic will be described below. Table 2 shows the measurement results of each sample.

(1) Viscosity Damping Factor The sample to be measured was filled in a glass container, and the viscosity of the sample was measured in that state, and this was taken as the initial viscosity (A1). Then, after leaving this container outdoors for one week without shading, the viscosity of the sample was measured again, and this was taken as the final viscosity (A2). The viscosity of the sample was measured by a method according to JIS Z 8803. Then, the viscosity attenuation rate of the sample was obtained from the following formula (I).
Viscosity decay rate (%) = | A2-A1 | / A1 x 100 ... (I)
Further, the viscosity attenuation rate of the gel-type pest repellent for human body of Example 1 was set to 1, and the relative ratio of the viscosity attenuation rates of each material was calculated.

(2) Active ingredient recovery rate The sample to be measured was filled in a glass container, and the content of the pest repellent component (active ingredient) of the sample was measured in that state, and this was taken as the initial content (B1). Then, after leaving this container outdoors for one week without shading, the content of the pest repellent component of the sample was measured again, and this was defined as the final content (B2). The content of the pest repellent component was measured by gas chromatography (manufactured by Shimadzu Corporation, model: GC14B). Then, the active ingredient recovery rate of the sample was determined from the following formula (II).
Active ingredient recovery rate (%) = B2 / B1 x 100 ... (II)

(3) Drying time The drying time of the sample was measured according to the following procedure in accordance with Section 2 of Part 3 of JIS K 5600. First, prepare two square glass plates (20 cm x 20 cm), place the sample (0.1 g) to be measured on one glass plate, spread it over the entire glass surface (test plot), and spread the other glass. The board is left untreated (control plot). 10 pieces of Styrofoam pieces (5 mm × 5 mm × 5 mm) are sprayed on the glass plates of the test group and the control group, and the number of Styrofoam pieces dropped by standing the glass plates vertically is counted. This operation was carried out every minute, and the time when the number of Styrofoam pieces dropped from the glass plates of the test group and the control group became the same was defined as the drying time.

(4) Turbidity The turbidity of the sample was measured in accordance with the 17th revision of the Japanese Pharmacopoeia / General Test Method 2.61 Turbidity Test Method.

As shown in Table 2, the gel-type pest repellents for human bodies of Examples 1 to 4, 6 and 7 have a viscosity attenuation rate of 5% or less, and have stable properties from the initial stage of use to the final stage of use. Since it was maintained, it was easy to use. In addition, no decrease in the active ingredient was observed, and it was confirmed that the repellent effect was maintained for a long period of time. Furthermore, the drying time was 11 minutes or less, and it was possible to quickly eliminate the sticky feeling after application to the skin. Regarding the gel-type pest repellent for human body of Example 5, the viscosity was attenuated and the active ingredient was slightly decreased, but the drying time was 11 minutes, which was not a problem in practical use. rice field.

On the other hand, the gel-type pest repellent for human body of Comparative Example 1 had a very large viscosity attenuation rate of about 90%, and could not maintain stable properties. It is considered that this is because the gel molecular structure of the pest repellent for humans is deteriorated and destroyed by ultraviolet rays because it does not contain ethylhexyl paramethoxycinnamate, which is an ultraviolet deterioration suppressing component. Further, in Comparative Example 1 containing no ethylhexyl paramethoxycinnamate, the active ingredient was also slightly reduced, and there was concern about the persistence of the repellent effect. Further, the drying time was longer than that of Examples 1 to 7, and after application to the skin, the sticky feeling could not be promptly eliminated, resulting in poor usability.

Regarding the gel-type pest repellent for humans of Comparative Example 2 containing DEET as a pest repellent component, the viscosity attenuation rate exceeded 10%, and it was difficult to maintain stable properties. In addition, it took 13 minutes to dry, and after application to the skin, the sticky feeling could not be quickly eliminated, resulting in poor usability.

The gel-type pest repellent for humans of Comparative Example 3 contains 20% by weight of icaridin as a pest repellent component, but does not contain ethylhexyl paramethoxycinnamate, which is an ultraviolet deterioration suppressing component, and therefore has the same viscosity as Comparative Example 1. The attenuation rate became a very large value (about 80%), and stable properties could not be maintained. In addition, since the active ingredient was reduced, there was concern about the sustainability of the repellent effect. Further, it took 14 minutes to dry, and after application to the skin, the sticky feeling could not be quickly eliminated, which was not easy to use.

The gel-type pest repellent for human body of Comparative Example 4 contained an excessive amount (30% by weight) of icaridin as a pest repellent component, so that a remarkable decrease in the active ingredient and a prolongation of the drying time were observed. In addition, since it does not contain ethylhexyl paramethoxycinnamic acid, which is an ultraviolet deterioration suppressing component, the viscosity attenuation rate becomes a very large value (about 80%) as in Comparative Example 1, and stable properties could not be maintained. ..

The gel-type pest repellent for humans of the present invention can be used for preventing bite damage caused by biting pests such as mosquitoes, gnats, bugs, ticks, stable flies, house mites, bed bugs, biting bugs, and yamabil.

Claims (11)

A water-soluble gel-type pest repellent for humans
Contains a gel base, a gelling agent, a pest repellent component, an ultraviolet deterioration suppressing component, and water.
The pest repellent components are 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-. At least one selected from the group consisting of 3,8-diols
The ultraviolet deterioration suppressing component, Ri paramethoxy Ethylhexyl der,
The content of the ultraviolet deterioration suppressing component is 0.1 to 1.0% by weight.
A gel-type pest repellent for humans in which the content of the gel base is 0.05 to 0.5% by weight. The gel-type pest repellent for humans according to claim 1, wherein the content of the pest repellent component is 3 to 20% by weight. The gel-type pest repellent for humans according to claim 1 or 2 , further containing the dispersant of the ultraviolet deterioration suppressing component. The gel-type pest repellent for humans according to claim 3 , wherein the dispersant is ethanol. The gel-type pest repellent for humans according to any one of claims 1 to 4 , further containing a moisturizer. The gel-type pest repellent for humans according to claim 5 , wherein the moisturizer is 1,3-butylene glycol and / or a seaweed extract. The gel-type human pest according to any one of claims 1 to 6, which is prepared so that the drying time measured in accordance with JIS K 5600, Part 3, Section 2 is 10 minutes or less. Repellent. 17th Amendment Japanese Pharmacopoeia General Test Method 2.61 Turbidity determined in accordance with the visual method of the turbidity test method is adjusted so that the turbidity is less than or equal to the turbidity comparison solution IV. Claims 1 to 7. The gel-type pest repellent for humans according to any one of the above. The gel-type pest repellent for humans according to any one of claims 1 to 8, which is prepared so that the viscosity measured according to JIS Z 8803 is 0.5 to 100 Pa · s. The viscosity measured in accordance with JIS Z 8803 is adjusted so that the viscosity attenuation rate obtained from the initial viscosity and the final viscosity measured after being left outdoors for one week without shading is 10% or less. The gel-type pest repellent for humans according to any one of claims 1 to 9. The gel-type pest repellent for humans according to any one of claims 1 to 10, which is applied to the head, face, or neck of the human body.