JP6960471B2 - Gel-type pest repellent for humans - Google Patents
Gel-type pest repellent for humans Download PDFInfo
- Publication number
- JP6960471B2 JP6960471B2 JP2019563971A JP2019563971A JP6960471B2 JP 6960471 B2 JP6960471 B2 JP 6960471B2 JP 2019563971 A JP2019563971 A JP 2019563971A JP 2019563971 A JP2019563971 A JP 2019563971A JP 6960471 B2 JP6960471 B2 JP 6960471B2
- Authority
- JP
- Japan
- Prior art keywords
- pest repellent
- gel
- humans
- type
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002940 repellent Effects 0.000 title claims description 203
- 239000005871 repellent Substances 0.000 title claims description 203
- 241000607479 Yersinia pestis Species 0.000 title claims description 201
- 241000282412 Homo Species 0.000 claims description 79
- 230000006866 deterioration Effects 0.000 claims description 49
- -1 Ethylhexyl Chemical group 0.000 claims description 25
- 238000001035 drying Methods 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 19
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical group CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 16
- QLHULAHOXSSASE-UHFFFAOYSA-N butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate Chemical compound CCC(C)OC(=O)N1CCCCC1CCO QLHULAHOXSSASE-UHFFFAOYSA-N 0.000 claims description 16
- 239000004909 Moisturizer Substances 0.000 claims description 14
- 230000001333 moisturizer Effects 0.000 claims description 14
- 239000002270 dispersing agent Substances 0.000 claims description 13
- 239000003349 gelling agent Substances 0.000 claims description 13
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 8
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 241001474374 Blennius Species 0.000 claims description 7
- ROBXZHNBBCHEIQ-UHFFFAOYSA-N ethyl 2-aminopropanoate Chemical compound CCOC(=O)C(C)N ROBXZHNBBCHEIQ-UHFFFAOYSA-N 0.000 claims description 5
- 238000010998 test method Methods 0.000 claims description 5
- 238000012812 general test Methods 0.000 claims description 4
- 230000000007 visual effect Effects 0.000 claims description 4
- CFJYNSNXFXLKNS-UHFFFAOYSA-N p-menthane Chemical compound CC(C)C1CCC(C)CC1 CFJYNSNXFXLKNS-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 35
- 230000000052 comparative effect Effects 0.000 description 22
- 230000000694 effects Effects 0.000 description 21
- 239000007788 liquid Substances 0.000 description 13
- 229950011440 icaridin Drugs 0.000 description 11
- 239000004480 active ingredient Substances 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- 239000011521 glass Substances 0.000 description 9
- LMXFTMYMHGYJEI-UHFFFAOYSA-N p-menthane-3,8-diol Chemical compound CC1CCC(C(C)(C)O)C(O)C1 LMXFTMYMHGYJEI-UHFFFAOYSA-N 0.000 description 8
- 229930006948 p-menthane-3,8-diol Natural products 0.000 description 8
- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 description 6
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229960001673 diethyltoluamide Drugs 0.000 description 6
- 241000255925 Diptera Species 0.000 description 5
- 229920002125 Sokalan® Polymers 0.000 description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 241000238876 Acari Species 0.000 description 3
- 206010004194 Bed bug infestation Diseases 0.000 description 3
- 241001414835 Cimicidae Species 0.000 description 3
- 241000258937 Hemiptera Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920006328 Styrofoam Polymers 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000008261 styrofoam Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000257226 Muscidae Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- WTWBUQJHJGUZCY-UHFFFAOYSA-N cuminaldehyde Chemical compound CC(C)C1=CC=C(C=O)C=C1 WTWBUQJHJGUZCY-UHFFFAOYSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- MBDOYVRWFFCFHM-SNAWJCMRSA-N (2E)-hexenal Chemical compound CCC\C=C\C=O MBDOYVRWFFCFHM-SNAWJCMRSA-N 0.000 description 1
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 description 1
- CUZKCNWZBXLAJX-UHFFFAOYSA-N 2-phenylmethoxyethanol Chemical compound OCCOCC1=CC=CC=C1 CUZKCNWZBXLAJX-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241000951471 Citrus junos Species 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- HMKKIXGYKWDQSV-KAMYIIQDSA-N alpha-Amylcinnamaldehyde Chemical compound CCCCC\C(C=O)=C\C1=CC=CC=C1 HMKKIXGYKWDQSV-KAMYIIQDSA-N 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- 229910000420 cerium oxide Inorganic materials 0.000 description 1
- 150000001851 cinnamic acid derivatives Chemical class 0.000 description 1
- 239000010632 citronella oil Substances 0.000 description 1
- 239000001279 citrus aurantifolia swingle expressed oil Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000010639 cypress oil Substances 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000010656 jasmine oil Substances 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- OMNKZBIFPJNNIO-UHFFFAOYSA-N n-(2-methyl-4-oxopentan-2-yl)prop-2-enamide Chemical compound CC(=O)CC(C)(C)NC(=O)C=C OMNKZBIFPJNNIO-UHFFFAOYSA-N 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/06—Oxygen or sulfur directly attached to a cycloaliphatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Description
本発明は、水溶性のジェルタイプの人体用害虫忌避剤に関する。 The present invention relates to a water-soluble gel-type pest repellent for humans.
従来、人体用害虫忌避剤としては、使用法が簡便なエアゾールタイプが主流であるが、害虫忌避成分を微粒子にして皮膚面に噴霧するため、使用者によっては鼻粘膜に刺激を感じる場合がある。また、エアゾールタイプの人体用害虫忌避剤では、塗布面に塗りむらが生じて害虫忌避成分の付着していない部分ができる場合があり、蚊等の刺咬害虫はこの僅かな部分を敏感に感知し吸血行動を起こす。そこで、塗りむらがなく、害虫忌避成分が飛散しにくいジェルタイプの害虫忌避剤が利用されている。 Conventionally, the aerosol type, which is easy to use, has been the mainstream as a pest repellent for the human body, but since the pest repellent component is made into fine particles and sprayed on the skin surface, some users may feel irritation to the nasal mucosa. .. In addition, with aerosol-type pest repellents for humans, there are cases where uneven coating occurs on the coated surface and there are areas where the pest repellent component does not adhere, and mosquitoes and other biting pests sensitively detect these small areas. Causes blood-sucking behavior. Therefore, a gel-type pest repellent that has no uneven coating and does not easily scatter pest repellent components is used.
例えば、害虫忌避成分とゲル基剤と水とを含有する人体用ゲル状害虫忌避組成物が開発されている(例えば、特許文献1を参照)。特許文献1の人体用ゲル状害虫忌避組成物は、害虫忌避成分の皮膚付着表示剤として、光沢剤とともにグリコールを配合している。 For example, a gel-like pest repellent composition for the human body containing a pest repellent component, a gel base, and water has been developed (see, for example, Patent Document 1). The gel-like pest repellent composition for human body of Patent Document 1 contains glycol together with a brightener as a skin adhesion indicator of a pest repellent component.
ジェルタイプの人体用害虫忌避剤を皮膚に塗布するにあたっては、内容物を手の平にとってから腕や脚等の皮膚に塗り延ばすか、又は腕や脚等の皮膚の一部に内容物を吐出後、手の平で皮膚の全面に塗り延ばす必要がある。そのため、使用時には、腕、脚等だけではなく、手の平にも人体用害虫忌避剤が付着する。ジェルタイプの人体用害虫忌避剤は、塗布後直ぐに手を洗えない野外での使用も想定されるが、野外活動中に手の平にべたつき感が生じることに不便さを感じ、使用者がジェルタイプの人体用害虫忌避剤の塗布をためらう虞がある。この点に関し、特許文献1の人体用ゲル状害虫忌避組成物は、皮膚付着表示剤の配合により塗布状態の視認性を向上するものであり、塗布に伴う手の平のべたつき感について考慮されたものではない。 When applying a gel-type pest repellent for humans to the skin, the contents should be applied to the skin such as arms and legs after the contents are placed on the palm, or after the contents are discharged to a part of the skin such as arms and legs. It should be spread over the entire surface of the skin with the palm of your hand. Therefore, at the time of use, the pest repellent for human body adheres not only to the arms and legs but also to the palm. The gel-type pest repellent for humans is expected to be used outdoors where the hands cannot be washed immediately after application, but the user feels inconvenienced by the feeling of stickiness on the palm during outdoor activities, and the user is a gel-type pest repellent. There is a risk of hesitating to apply a pest repellent for the human body. In this regard, the gel-like pest repellent composition for human body of Patent Document 1 improves the visibility of the applied state by blending a skin adhesion indicator, and does not take into consideration the sticky feeling of the palm due to the application. No.
本発明は、上記問題点に鑑みてなされたものであり、塗布に伴う手の平のべたつき感により不便さが生じることを低減することができるジェルタイプの人体用害虫忌避剤を提供することを目的とする。 The present invention has been made in view of the above problems, and an object of the present invention is to provide a gel-type pest repellent for humans that can reduce inconvenience caused by the sticky feeling of the palm associated with application. do.
上記課題を解決するための本発明に係るジェルタイプの人体用害虫忌避剤の特徴構成は、
水溶性のジェルタイプの人体用害虫忌避剤であって、
ゲル基剤と、ゲル化剤と、害虫忌避成分と、紫外線劣化抑制成分と、水とを含み、
前記害虫忌避成分は、2−(2−ヒドロキシエチル)−1−ピペリジンカルボン酸1−メチルプロピルエステル、3−(N−n−ブチル−N−アセチル)アミノプロピオン酸エチルエステル、及びp−メンタン−3,8−ジオールからなる群から選択される少なくとも一つであり、
前記紫外線劣化抑制成分は、パラメトキシ桂皮酸エチルヘキシルであることにある。The characteristic composition of the gel type pest repellent for human body according to the present invention for solving the above problems is as follows.
A water-soluble gel-type pest repellent for humans
Contains a gel base, a gelling agent, a pest repellent component, an ultraviolet deterioration suppressing component, and water.
The pest repellent components are 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-. At least one selected from the group consisting of 3,8-diols
The ultraviolet deterioration inhibitory component is ethylhexyl paramethoxycinnamate.
本構成のジェルタイプの人体用害虫忌避剤によれば、従来のジェルタイプの人体用害虫忌避剤において害虫忌避成分として用いられていたディートよりも害虫忌避効力の持続性に優れた2−(2−ヒドロキシエチル)−1−ピペリジンカルボン酸1−メチルプロピルエステル、3−(N−n−ブチル−N−アセチル)アミノプロピオン酸エチルエステル、及びp−メンタン−3,8−ジオールからなる群から選択される少なくとも一つを用いるため、害虫忌避効力を維持するために塗りなおす回数を減らすことが可能となり、塗布後においては短い時間で乾燥してべたつき感を速やかに解消することができる。さらに、紫外線劣化抑制成分として、紫外線吸収性の高いパラメトキシ桂皮酸エチルヘキシルを含有するため、紫外線量の多い夏季の使用であっても、塗布後に紫外線の暴露によって害虫忌避成分が劣化することを抑制して忌避効力の持続性を向上させることができ、頻繁な塗り直しが必要になることを防ぐことができる。これらの結果、手の平にべたつき感のない状態が長く維持され、手の平のべたつき感により不便さが生じることを低減することができるため、使用者は本構成のジェルタイプの人体用害虫忌避剤をためらうことなく使用することができる。 According to the gel-type human pest repellent having this configuration, the sustainability of the pest repellent effect is superior to that of DEET, which has been used as a pest repellent component in the conventional gel-type human pest repellent 2- (2). -Hydroxyethyl) -1-piperidin Carboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-3,8-diol selected from the group Since at least one of the esters is used, it is possible to reduce the number of recoatings in order to maintain the pest repellent effect, and after the coating, it dries in a short time and the sticky feeling can be quickly eliminated. Furthermore, since it contains ethylhexyl paramethoxycinnamate, which has high ultraviolet absorption, as an ultraviolet deterioration suppressing component, it suppresses the deterioration of the pest repellent component due to exposure to ultraviolet rays even when used in the summer when the amount of ultraviolet rays is large. Therefore, the sustainability of the repellent effect can be improved, and frequent repainting can be prevented. As a result, the non-sticky state of the palm can be maintained for a long time, and the inconvenience caused by the sticky feeling of the palm can be reduced. Therefore, the user hesitates to use the gel-type pest repellent for humans in this configuration. Can be used without.
本発明に係るジェルタイプの人体用害虫忌避剤において、
前記害虫忌避成分の含有量は、3〜20重量%であることが好ましい。In the gel-type pest repellent for humans according to the present invention,
The content of the pest repellent component is preferably 3 to 20% by weight.
本構成のジェルタイプの人体用害虫忌避剤によれば、害虫忌避成分を上記の範囲で含有することによって、害虫忌避効力を十分に持続させることが可能でありながら、塗布後に短い時間で乾燥し、手の平のべたつき感を速やかに解消することができる。 According to the gel-type pest repellent for humans having this composition, by containing the pest repellent component in the above range, the pest repellent effect can be sufficiently maintained, but the pest repellent is dried in a short time after application. , The sticky feeling of the palm can be quickly eliminated.
本発明に係るジェルタイプの人体用害虫忌避剤において、
前記紫外線劣化抑制成分の含有量は、0.1〜1.0重量%であることが好ましい。In the gel-type pest repellent for humans according to the present invention,
The content of the ultraviolet deterioration suppressing component is preferably 0.1 to 1.0% by weight.
本構成のジェルタイプの人体用害虫忌避剤によれば、紫外線劣化抑制成分を上記の範囲で含有するため、紫外線劣化抑制成分の粘性が緩和され、塗布時にべたつき感を引き起こすことなく、紫外線による害虫忌避成分の劣化を十分に抑制することができる。 According to the gel-type pest repellent for human body of this composition, since the ultraviolet deterioration suppressing component is contained in the above range, the viscosity of the ultraviolet deterioration suppressing component is relaxed, and the pest caused by ultraviolet rays does not cause a sticky feeling at the time of application. Deterioration of the repellent component can be sufficiently suppressed.
本発明に係るジェルタイプの人体用害虫忌避剤において、
前記紫外線劣化抑制成分の分散剤をさらに含有することが好ましい。In the gel-type pest repellent for humans according to the present invention,
It is preferable to further contain the dispersant of the ultraviolet deterioration suppressing component.
本構成のジェルタイプの人体用害虫忌避剤によれば、紫外線劣化抑制成分の分散剤を含有することによって、紫外線劣化抑制成分が油溶性である場合でも均一な状態で分散させることができる。 According to the gel-type pest repellent for humans having this configuration, by containing the dispersant of the ultraviolet deterioration suppressing component, even when the ultraviolet deterioration suppressing component is oil-soluble, it can be dispersed in a uniform state.
本発明に係るジェルタイプの人体用害虫忌避剤において、
前記分散剤は、エタノールであることが好ましい。In the gel-type pest repellent for humans according to the present invention,
The dispersant is preferably ethanol.
本構成のジェルタイプの人体用害虫忌避剤によれば、分散剤としてエタノールを用いることによって、塗布時に清涼感を付与して、手の平のべたつき感を軽減することができる。 According to the gel-type pest repellent for humans having this configuration, by using ethanol as a dispersant, it is possible to impart a refreshing feeling at the time of application and reduce the sticky feeling of the palm.
本発明に係るジェルタイプの人体用害虫忌避剤において、
保湿剤をさらに含有することが好ましい。In the gel-type pest repellent for humans according to the present invention,
It is preferable to further contain a moisturizer.
本構成のジェルタイプの人体用害虫忌避剤によれば、保湿剤を含有することによって、塗布後に人体用害虫忌避剤が過度に乾燥することを防いで害虫忌避成分の皮膚への付着性を高めるとともに、塗布時にしっとり感を付与して、手の平のべたつき感を軽減することができる。 According to the gel-type pest repellent for humans having this configuration, the inclusion of a moisturizer prevents the pest repellent for humans from drying excessively after application and enhances the adhesion of the pest repellent component to the skin. At the same time, it is possible to give a moist feeling at the time of application and reduce the sticky feeling of the palm.
本発明に係るジェルタイプの人体用害虫忌避剤において、
前記保湿剤は、1,3−ブチレングリコール、及び/又は海藻エキスであることが好ましい。In the gel-type pest repellent for humans according to the present invention,
The moisturizer is preferably 1,3-butylene glycol and / or seaweed extract.
本構成のジェルタイプの人体用害虫忌避剤によれば、保湿剤として上記の物質を用いることによって、害虫忌避成分の皮膚への付着性、及び塗布時のしっとり感が優れたものとなる。 According to the gel-type pest repellent for humans having the present constitution, by using the above-mentioned substance as a moisturizer, the pest repellent component adheres to the skin and the moist feeling at the time of application becomes excellent.
本発明に係るジェルタイプの人体用害虫忌避剤において、
JIS K 5600の第3部第2節に準拠して測定される乾燥時間が10分以下となるように調製されていることが好ましい。In the gel-type pest repellent for humans according to the present invention,
It is preferable that the drying time is adjusted to be 10 minutes or less as measured in accordance with JIS K 5600, Part 3, Section 2.
本構成のジェルタイプの人体用害虫忌避剤によれば、乾燥時間が10分以下となるように調製されていることによって、人体用害虫忌避剤を皮膚に塗布した後に乾燥するまでの時間を十分に短くすることができ、手の平のべたつき感を速やかに解消することができる。 According to the gel-type pest repellent for humans having this configuration, the drying time is adjusted to 10 minutes or less, so that the time from applying the pest repellent for humans to the skin to drying is sufficient. It can be shortened to, and the sticky feeling of the palm can be quickly eliminated.
本発明に係るジェルタイプの人体用害虫忌避剤において、
第17改正日本薬局方・一般試験法 2.61濁度試験法の目視法に準拠して判定される濁度が、濁りの比較液IV以下となるように調製されていることが好ましい。In the gel-type pest repellent for humans according to the present invention,
It is preferable that the turbidity determined in accordance with the visual method of the 17th revised Japanese Pharmacopoeia / General Test Method 2.61 Turbidity Test Method is adjusted to be less than or equal to the turbidity comparison solution IV.
本構成のジェルタイプの人体用害虫忌避剤によれば、濁度試験法の目視法に準拠して判定される濁度が、濁りの比較液IV以下となるように調製されていることによって、皮膚に塗布した場合に白浮きすることがなく、みずみずしい見た目が得られる。 According to the gel-type pest repellent for humans having this configuration, the turbidity determined according to the visual method of the turbidity test method is adjusted to be equal to or less than the turbidity comparison liquid IV. When applied to the skin, it does not appear white and gives a fresh appearance.
本発明に係るジェルタイプの人体用害虫忌避剤において、
JIS Z 8803に準拠して測定される粘度が0.5〜100Pa・sとなるように調製されていることが好ましい。In the gel-type pest repellent for humans according to the present invention,
It is preferable that the viscosity measured according to JIS Z 8803 is adjusted to be 0.5 to 100 Pa · s.
本構成のジェルタイプの人体用害虫忌避剤によれば、粘度が0.5〜100Pa・sとなるように調製されていることによって、皮膚に塗り延ばしやすく、害虫忌避成分の皮膚への優れた付着性、展延性が得られる。 According to the gel-type pest repellent for humans having this composition, it is easy to spread on the skin because the viscosity is adjusted to 0.5 to 100 Pa · s, and the pest repellent component is excellent on the skin. Adhesiveness and malleability can be obtained.
本発明に係るジェルタイプの人体用害虫忌避剤において、
JIS Z 8803に準拠して測定される粘度について、初期粘度と、遮光しない状態で屋外に一週間放置した後に測定される終期粘度とから求められる粘度減衰率が10%以下となるように調製されていることが好ましい。In the gel-type pest repellent for humans according to the present invention,
The viscosity measured in accordance with JIS Z 8803 is adjusted so that the viscosity attenuation rate obtained from the initial viscosity and the final viscosity measured after being left outdoors for one week without shading is 10% or less. Is preferable.
本構成のジェルタイプの人体用害虫忌避剤によれば、粘度減衰率が10%以下となるように調製されていることによって、使用初期から使用終期まで安定した性状を維持するものとなり、使い勝手に優れた製品とすることができる。 According to the gel-type pest repellent for humans having this configuration, the viscosity attenuation rate is adjusted to 10% or less, so that stable properties are maintained from the initial stage of use to the end of use, which makes it easy to use. It can be an excellent product.
本発明に係るジェルタイプの人体用害虫忌避剤において、人体の頭部、顔面、又は首に塗布するために用いられることが好ましい。 In the gel type pest repellent for human body according to the present invention, it is preferably used for application to the head, face or neck of the human body.
本構成のジェルタイプの人体用害虫忌避剤によれば、害虫忌避成分が飛散しにくいジェルタイプであり、害虫忌避成分、及び紫外線劣化抑制成分の夫々に皮膚への刺激が比較的穏やかな2−(2−ヒドロキシエチル)−1−ピペリジンカルボン酸1−メチルプロピルエステル、3−(N−n−ブチル−N−アセチル)アミノプロピオン酸エチルエステル、及びp−メンタン−3,8−ジオールからなる群から選択される少なくとも一つと、パラメトキシ桂皮酸エチルヘキシルとを使用していることで、人体の腕、脚だけではなく、特にデリケートな部位である頭部、顔面、又は首に塗布するために用いることに適したものとなる。 According to the gel-type pest repellent for human body of this composition, the pest repellent component is a gel type that does not easily scatter, and the pest repellent component and the ultraviolet deterioration suppressing component each have relatively mild irritation to the skin 2- A group consisting of (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-3,8-diol. By using at least one selected from and ethylhexyl paramethoxycinnamate, it can be applied not only to the arms and legs of the human body, but also to the head, face, or neck, which are particularly delicate areas. It will be suitable for.
以下、本発明のジェルタイプの人体用害虫忌避剤について説明する。ただし、本発明は、以下に説明する実施形態に記載される構成に限定されることを意図しない。 Hereinafter, the gel-type pest repellent for humans of the present invention will be described. However, the present invention is not intended to be limited to the configurations described in the embodiments described below.
[人体用害虫忌避剤]
本発明のジェルタイプの人体用害虫忌避剤は、水溶性のジェルタイプの人体用害虫忌避剤であり、ゲル基剤と、ゲル化剤と、害虫忌避成分と、紫外線劣化抑制成分とを含有する。本発明のジェルタイプの人体用害虫忌避剤の主成分の一つである害虫忌避成分は、2−(2−ヒドロキシエチル)−1−ピペリジンカルボン酸1−メチルプロピルエステル[以下、イカリジンと称する]、3−(N−n−ブチル−N−アセチル)アミノプロピオン酸エチルエステル[以下、IR3535と称する]、又はp−メンタン−3,8−ジオールである。これらの害虫忌避成分は、単独で使用してもよいし、複数種を組み合わせて使用してもよい。イカリジン、IR3535、及びp−メンタン−3,8−ジオールは、従来のジェルタイプの人体用害虫忌避剤において害虫忌避成分として広く使用されているディートと比較して、害虫忌避効力の持続性に優れる。そのため、本発明のジェルタイプの人体用害虫忌避剤は、ディートを配合した従来のものと比較して、害虫忌避効力を維持するために塗りなおす回数を減らすことが可能であり、塗布後に短い時間で乾燥する。本発明の人体用害虫忌避剤における害虫忌避成分の含有量は、3〜20重量%が好ましい。害虫忌避成分の含有量がこのような範囲であれば、害虫忌避効力を十分に持続させることが可能でありながら、塗布後に乾燥するまでの時間を十分に短くすることができ、手の平のべたつき感を速やかに解消することができる。害虫忌避成分の含有量が3重量%未満である場合、皮膚に付着した害虫忌避成分が揮散により早期に失われ害虫忌避効力の持続時間が短いものとなる。そのため、頻繁な人体用害虫忌避剤の塗り直しが必要となり、その度に手の平のべたつき感が生じることになる。害虫忌避成分の含有量が20重量%を超える場合、塗布後の乾燥に時間がかかる場合がある。[Pest repellent for human body]
The gel-type pest repellent for humans of the present invention is a water-soluble gel-type pest repellent for humans, and contains a gel base, a gelling agent, a pest repellent component, and an ultraviolet deterioration suppressing component. .. The pest repellent component, which is one of the main components of the gel-type pest repellent for humans of the present invention, is 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester [hereinafter referred to as icaridin]. , 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester [hereinafter referred to as IR3535], or p-menthane-3,8-diol. These pest repellent components may be used alone or in combination of two or more. Icaridin, IR3535, and p-menthane-3,8-diol have a longer lasting pest repellent effect than DEET, which is widely used as a pest repellent component in conventional gel-type human pest repellents. .. Therefore, the gel-type pest repellent for humans of the present invention can reduce the number of recoatings in order to maintain the pest repellent effect as compared with the conventional one containing DEET, and it takes a short time after application. To dry. The content of the pest repellent component in the pest repellent for human body of the present invention is preferably 3 to 20% by weight. When the content of the pest repellent component is within such a range, the pest repellent effect can be sufficiently maintained, but the time until drying after application can be sufficiently shortened, and the palm feels sticky. Can be resolved promptly. When the content of the pest repellent component is less than 3% by weight, the pest repellent component adhering to the skin is lost early due to volatilization, and the duration of the pest repellent effect is short. Therefore, it is necessary to frequently reapply the pest repellent for the human body, and each time, a sticky feeling of the palm is generated. If the content of the pest repellent component exceeds 20% by weight, it may take time to dry after application.
ジェルタイプの人体用害虫忌避剤は、刺咬害虫が出現しやすい夏季に野外で使用することが想定されるが、夏季の野外環境では紫外線量も多い。使用時に紫外線によって害虫忌避成分が劣化することを想定して、害虫忌避成分の含有量を増やして人体用害虫忌避剤を調製すると、塗布後の乾燥に時間がかかる場合がある。また、害虫忌避成分の含有量を過剰に増やすことは、経済的にも不利である。そこで、本発明のジェルタイプの人体用害虫忌避剤には、塗布後に紫外線の暴露によって害虫忌避成分が劣化することを抑制するために、紫外線劣化抑制成分を配合している。本発明で用いる紫外線劣化抑制成分は、パラメトキシ桂皮酸エチルヘキシルである。パラメトキシ桂皮酸エチルヘキシルは、紫外線の吸収性に優れるため、人体用害虫忌避剤に配合することで、紫外線による害虫忌避成分の劣化を抑制して、忌避効力の持続性を向上させることができる。そのため、害虫忌避成分の含有量を過剰に増やす必要がなく、また、夏季の使用において害虫忌避効力を維持するために人体用害虫忌避剤を塗りなおす回数を減らすことができ、頻繁な塗り直しにより手の平にべたつき感が繰り返し生じることを防ぐことができる。また、パラメトキシ桂皮酸エチルヘキシルは、透明の液体であり人体用害虫忌避剤に配合しても人体用害虫忌避剤の澄明性を大きく損なうことがない。紫外線劣化抑制成分としては、オキシベンゾン等のベンゾフェノン誘導体や桂皮酸誘導体等の紫外線吸収性に優れた有機化合物を用いることも可能である。また、有機化合物だけではなく、紫外線散乱剤である酸化チタン、酸化亜鉛、酸化セリウム等の無機粉体を、人体用害虫忌避剤の澄明性を損なわない程度に適宜配合してもよい。 Gel-type pest repellents for humans are expected to be used outdoors in the summer when biting pests are likely to appear, but the amount of ultraviolet rays is large in the outdoor environment in the summer. Assuming that the pest repellent component is deteriorated by ultraviolet rays during use, if the pest repellent component for human body is prepared by increasing the content of the pest repellent component, it may take time to dry after application. In addition, it is economically disadvantageous to excessively increase the content of the pest repellent component. Therefore, the gel-type pest repellent for humans of the present invention contains an ultraviolet deterioration suppressing component in order to suppress deterioration of the pest repellent component due to exposure to ultraviolet rays after application. The ultraviolet deterioration suppressing component used in the present invention is ethylhexyl paramethoxycinnamate. Since ethylhexyl paramethoxycinnamate has excellent absorption of ultraviolet rays, it is possible to suppress deterioration of the pest repellent component due to ultraviolet rays and improve the sustainability of the repellent effect by adding it to a pest repellent for humans. Therefore, it is not necessary to excessively increase the content of the pest repellent component, and the number of times of reapplying the human pest repellent to maintain the pest repellent effect in summer use can be reduced. It is possible to prevent repeated sticky feelings on the palm. Further, ethylhexyl paramethoxycinnamate is a transparent liquid, and even if it is blended with a pest repellent for humans, the clarity of the pest repellent for humans is not significantly impaired. As the ultraviolet deterioration suppressing component, it is also possible to use an organic compound having excellent ultraviolet absorption such as a benzophenone derivative such as oxybenzone or a cinnamic acid derivative. Further, not only the organic compound but also inorganic powders such as titanium oxide, zinc oxide, and cerium oxide, which are ultraviolet scattering agents, may be appropriately blended to the extent that the clarity of the pest repellent for human bodies is not impaired.
本発明の人体用害虫忌避剤における紫外線劣化抑制成分の含有量は、0.1〜1.0重量%が好ましい。紫外線劣化抑制成分の含有量がこのような範囲であれば、紫外線による害虫忌避成分の劣化を抑制して、忌避効力の持続性を十分に維持することができる。その結果、害虫忌避効力の持続性と、乾燥性とのバランスが良いものとなる。紫外線劣化抑制成分の含有量が0.1重量%未満である場合、紫外線による害虫忌避成分の劣化を十分に抑制することができず、害虫忌避効力の持続時間が短いものとなるため、頻繁に人体用害虫忌避剤を塗りなおす必要があり、その度にべたつき感が生じることになる。紫外線劣化抑制成分の含有量が1.0重量%を超える場合、害虫忌避成分であるパラメトキシ桂皮酸エチルヘキシルは、油溶性で粘性を有するため、塗布時のべたつき感が強くなる虞がある。また、実用上必要な紫外線劣化抑制効力が得られる量を超えて紫外線劣化抑制成分を配合することになり、経済的にも不利である。 The content of the ultraviolet deterioration suppressing component in the pest repellent for human body of the present invention is preferably 0.1 to 1.0% by weight. When the content of the ultraviolet deterioration suppressing component is within such a range, the deterioration of the pest repellent component due to ultraviolet rays can be suppressed, and the sustainability of the repellent effect can be sufficiently maintained. As a result, the sustainability of the pest repellent effect and the dryness are well balanced. When the content of the ultraviolet deterioration suppressing component is less than 0.1% by weight, the deterioration of the pest repellent component due to ultraviolet rays cannot be sufficiently suppressed, and the duration of the pest repellent effect becomes short, so that it is frequently performed. It is necessary to reapply the pest repellent for human body, and each time it becomes sticky. When the content of the ultraviolet deterioration suppressing component exceeds 1.0% by weight, the pest repellent component ethylhexyl paramethoxycinnamic acid is oil-soluble and has a viscosity, so that there is a possibility that the sticky feeling at the time of application becomes strong. In addition, the amount of the ultraviolet deterioration suppressing component that is practically necessary is exceeded, which is economically disadvantageous.
本発明で用いるゲル基剤としては、カルボキシビニルポリマーや、ポリビニルアルコール、ポリビニルピロリドン等の水溶性高分子、アクリル酸共重合体、アクリル酸/メタクリル酸アルキル共重合体、アクリル酸アルキル/ジアセトンアクリルアミド共重合体等のアクリル酸系高分子化合物、アルギン酸及びその塩類等の多糖類等が挙げられ、特に、カルボキシビニルポリマーが好ましい。これらのゲル基剤は、水溶液中でチキソトロピー性を有し、少量で十分な増粘効果を示す。ゲル基剤の含有量は、0.05〜0.5重量%が好ましい。ゲル基剤の含有量がこのような範囲であれば、人体用害虫忌避剤に十分な粘性を与えることができ、害虫忌避成分の皮膚への優れた付着性、展延性が得られる。ゲル基剤の含有量が0.05重量%未満である場合、人体用害虫忌避剤の粘性が不足し、扱いにくいものとなる虞がある。ゲル基剤の含有量が0.5重量%を超える場合、過剰な粘性により展延性、肌なじみが悪くなる虞がある。 The gel base used in the present invention includes a carboxyvinyl polymer, a water-soluble polymer such as polyvinyl alcohol and polyvinylpyrrolidone, an acrylate copolymer, an acrylate / alkyl methacrylate copolymer, and an alkyl acrylate / diacetone acrylamide. Examples thereof include acrylic acid-based polymer compounds such as copolymers, polysaccharides such as alginic acid and salts thereof, and carboxyvinyl polymers are particularly preferable. These gel bases have thixotropy in an aqueous solution and exhibit a sufficient thickening effect even in a small amount. The content of the gel base is preferably 0.05 to 0.5% by weight. When the content of the gel base is within such a range, the pest repellent for humans can be sufficiently viscous, and the pest repellent component can be excellently adhered to the skin and spreadable. If the content of the gel base is less than 0.05% by weight, the viscosity of the pest repellent for humans may be insufficient and it may become difficult to handle. If the content of the gel base exceeds 0.5% by weight, there is a risk that ductility and skin compatibility will deteriorate due to excessive viscosity.
ゲル化剤は、pHの調整によりゲル基剤の増粘性を高めるものである。本発明で用いるゲル化剤としては、トリエタノールアミン、テトラヒドロキシプロピルエチレンジアミン等のアミン類、水酸化ナトリウム、アミノメチルプロパノール等が挙げられ、特に、トリエタノールアミンが好ましい。人体用害虫忌避剤においてゲル化剤の含有量は、ゲル基剤の含有量に応じて調整されるが、0.01〜0.6重量%が好ましい。ゲル化剤の含有量が0.01重量%未満である場合、ゲル基剤の増粘性を十分に高めることができない場合がある。ゲル化剤の含有量が0.6重量%を超える場合、ゲル基剤の増粘性を過剰に高め、展延性、肌なじみが悪くなる虞がある。 The gelling agent enhances the viscosity of the gel base by adjusting the pH. Examples of the gelling agent used in the present invention include amines such as triethanolamine and tetrahydroxypropylethylenediamine, sodium hydroxide, aminomethylpropanol and the like, and triethanolamine is particularly preferable. The content of the gelling agent in the human pest repellent is adjusted according to the content of the gel base, but is preferably 0.01 to 0.6% by weight. If the content of the gelling agent is less than 0.01% by weight, it may not be possible to sufficiently increase the viscosity of the gel base. If the content of the gelling agent exceeds 0.6% by weight, the thickening of the gel base may be excessively increased, resulting in poor ductility and skin compatibility.
本発明では、前記各成分に加え、紫外線劣化抑制成分の分散剤、保湿剤、芳香成分等を適宜配合してもよい。紫外線劣化抑制成分の分散剤としては、エタノール、イソプロパノール等のアルコール類が挙げられ、特に、エタノールが好ましい。分散剤の含有量は、10〜50重量%が好ましい。分散剤の含有量がこのような範囲であれば、人体用害虫忌避剤において油溶性のパラメトキシ桂皮酸エチルヘキシルを均一な状態で分散させることができるとともに、塗布時の清涼感を付与することもできる。分散剤の含有量が10重量%未満である場合、パラメトキシ桂皮酸エチルヘキシルを十分に分散させることができない虞がある。分散剤の含有量が50重量%を超える場合、皮膚への刺激が強くなる虞がある。 In the present invention, in addition to the above-mentioned components, a dispersant, a moisturizer, an aroma component, etc., which are components for suppressing ultraviolet deterioration, may be appropriately blended. Examples of the dispersant of the ultraviolet deterioration suppressing component include alcohols such as ethanol and isopropanol, and ethanol is particularly preferable. The content of the dispersant is preferably 10 to 50% by weight. When the content of the dispersant is within such a range, the oil-soluble ethylhexyl paramethoxycinnamate can be uniformly dispersed in the pest repellent for humans, and a refreshing feeling at the time of application can be imparted. .. If the content of the dispersant is less than 10% by weight, ethylhexyl paramethoxycinnamate may not be sufficiently dispersed. If the content of the dispersant exceeds 50% by weight, the irritation to the skin may become strong.
保湿剤としては、1,3−ブチレングリコール、プロピレングリコール、ジプロピレングリコール、トリプロピレングリコール、ジエチレングリコール、トリエチレングリコール、ヘキシレングリコール、及びベンジルグリコール等のグリコール類、海藻エキス等が挙げられ、特に、1,3−ブチレングリコール、及び海藻エキスが好ましい。保湿剤の含有量は、0.1〜10重量%であることが好ましい。保湿剤の含有量がこのような範囲であれば、塗布後に人体用害虫忌避剤が乾燥し過ぎることを防ぐことで、害虫忌避成分の皮膚への付着性を高めるとともに、しっとり感を付与することもできる。保湿剤の含有量が0.1重量%未満である場合、塗布後に人体用害虫忌避剤が過度に乾燥する虞がある。保湿剤の含有量が10重量%を超える場合、塗布後の乾燥に時間がかかり、手の平のべたつき感が速やかに解消されない虞がある。 Examples of the moisturizing agent include glycols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, diethylene glycol, triethylene glycol, hexylene glycol, and benzyl glycol, seaweed extract, and the like. 1,3-butylene glycol and seaweed extract are preferred. The content of the moisturizer is preferably 0.1 to 10% by weight. When the content of the moisturizer is within such a range, the pest repellent for humans can be prevented from becoming too dry after application, thereby enhancing the adhesion of the pest repellent component to the skin and giving a moist feeling. You can also. If the content of the moisturizer is less than 0.1% by weight, the human pest repellent may be excessively dried after application. If the content of the moisturizer exceeds 10% by weight, it takes time to dry after application, and the sticky feeling of the palm may not be quickly eliminated.
芳香成分としては、オレンジ油、レモン油、ラベンダー油、ペパーミント油、ユーカリ油、シトロネラ油、ライム油、ユズ油、ジャスミン油、檜油、緑茶精油、リモネン、α−ピネン、リナロール、ゲラニオール、フェニルエチルアルコール、アミルシンナミックアルデヒド、クミンアルデヒド、ベンジルアセテート等の芳香成分、「緑の香り」と呼ばれる青葉アルコールや青葉アルデヒド配合の香料成分などが挙げられる。 Aroma components include orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, cypress oil, green tea essential oil, limonene, α-pinene, linalol, geraniol, phenylethyl. Examples include aromatic components such as alcohol, amylcinnamic aldehyde, cumin aldehyde, and benzyl acetate, and fragrance components containing green leaf alcohol and green leaf aldehyde called "green scent".
[乾燥性]
本発明のジェルタイプの人体用害虫忌避剤の乾燥性は、JIS K 5600の第3部第2節に準拠して測定される表面の乾燥時間(以下、単に「乾燥時間」と称する。)が、10分以下となるように調製されていることが好ましい。乾燥時間が10分以下であれば、人体用害虫忌避剤を皮膚に塗布した後に乾燥するまでの時間を十分に短くすることができ、手の平のべたつき感を速やかに解消することができる。乾燥時間が10分を超える場合、塗布後の乾燥に時間がかかり、手の平のべたつき感を速やかに解消できない虞がある。[Dryness]
The drying property of the gel-type pest repellent for humans of the present invention is determined by the surface drying time (hereinafter, simply referred to as "drying time") measured in accordance with Part 3, Section 2 of JIS K 5600. It is preferably prepared so as to take 10 minutes or less. When the drying time is 10 minutes or less, the time from applying the pest repellent for human body to the skin to drying can be sufficiently shortened, and the sticky feeling of the palm can be quickly eliminated. If the drying time exceeds 10 minutes, it takes time to dry after application, and there is a possibility that the sticky feeling of the palm cannot be quickly eliminated.
[濁度]
本発明のジェルタイプの人体用害虫忌避剤の濁度は、第17改正日本薬局方・一般試験法 2.61濁度試験法の目視法に準拠した判定において「濁りの比較液IV以下」(30NTU以下)となるように調製されていることが好ましい。濁度が濁りの比較液IV以下(30NTU以下)であれば、皮膚に塗布した場合に白浮きすることがなく、みずみずしい見た目となる。濁度が30NTUを超える場合、皮膚に塗布した場合に白浮きする虞がある。[Turbidity]
The turbidity of the gel-type pest repellent for humans of the present invention was determined to be "turbidity comparison solution IV or less" in the judgment based on the visual method of the 17th revised Japanese Pharmacopoeia General Test Method 2.61 Turbidity Test Method. It is preferable that the content is 30 NTU or less). If the turbidity is turbidity comparative liquid IV or less (30 NTU or less), whitening does not occur when applied to the skin, and the appearance is fresh. If the turbidity exceeds 30 NTU, there is a risk of whitening when applied to the skin.
[チキソトロピー性(粘度)]
本発明のジェルタイプの人体用害虫忌避剤は、JIS Z 8803に準拠して測定される粘度(以下、単に「粘度」と称する。)が、0.5〜100Pa・sとなるように調製されていることが好ましい。粘度がこのような範囲であれば、皮膚に塗り延ばしやすく、害虫忌避成分の皮膚への優れた付着性、展延性が得られる。特に、本発明のジェルタイプの人体用害虫忌避剤は、チキソトロピー性を有し、せん断応力を与えた後である使用時の測定値がせん断応力を与える前である未使用時の測定値よりも小さくなるように調製されていることが好ましい。使用時の測定値が未使用時の測定値よりも小さければ、未使用時の比較的大きな粘度によって、チューブ容器に安定した状態で保存することができ、使用時の比較的小さな粘度によって、皮膚に塗り延ばしやすくなり、害虫忌避成分の皮膚への優れた付着性、展延性が得られるため、保存性の良さと使用時の塗り延ばしやすさとのバランスが優れたものとなる。[Thixotropy (viscosity)]
The gel-type pest repellent for humans of the present invention is prepared so that the viscosity measured in accordance with JIS Z 8803 (hereinafter, simply referred to as "viscosity") is 0.5 to 100 Pa · s. Is preferable. When the viscosity is in such a range, it is easy to spread on the skin, and excellent adhesion and ductility of the pest repellent component to the skin can be obtained. In particular, the gel-type pest repellent for humans of the present invention has thixotropy property, and the measured value at the time of use after applying the shear stress is higher than the measured value at the time of not using before applying the shear stress. It is preferably prepared to be small. If the measured value in use is smaller than the measured value in use, it can be stored in a stable state in a tube container due to the relatively large viscosity when not in use, and the skin due to the relatively small viscosity when used. It becomes easy to spread on the skin, and excellent adhesion and spreadability of the pest repellent component to the skin can be obtained, so that the balance between good storage stability and ease of spreading during use is excellent.
[人体用害虫忌避剤の用途]
本発明の人体用害虫忌避剤は、害虫忌避成分が飛散しにくいジェルタイプであり、害虫忌避成分、及び紫外線劣化抑制成分の含有量が上述の範囲に抑えられていることで、人体の腕、脚だけではなく、特にデリケートな部位である頭部、顔面、又は首に塗布するために用いることができる。また、本発明のジェルタイプの人体用害虫忌避剤は、蚊、ブヨ、アブ、マダニ、サシバエ、イエダニ、ナンキンムシ、ヌカカ、ヤマビル等の刺咬害虫に対して高い害虫忌避効果を示し、これらの刺咬被害を防ぐために用いることができる。[Use of pest repellent for human body]
The pest repellent for the human body of the present invention is a gel type in which the pest repellent component is hard to scatter, and the content of the pest repellent component and the ultraviolet deterioration suppressing component is suppressed within the above range, so that the arm of the human body, It can be used not only on the legs, but also on the head, face, or neck, which are particularly delicate areas. In addition, the gel-type pest repellent for humans of the present invention shows a high pest repellent effect against biting pests such as mosquitoes, gnats, abs, ticks, stable flies, bedbugs, bed bugs, biting bugs, and yamabils, and these pests It can be used to prevent bite damage.
[調製方法]
本発明のジェルタイプの人体用害虫忌避剤は、精製水にゲル基剤を分散させ、この液中に害虫忌避成分であるイカリジン、IR3535、及び/又はp−メンタン−3,8−ジオールと、紫外線劣化抑制成分であるパラメトキシ桂皮酸エチルヘキシルとを添加し、混合した後に、ゲル化剤(pH調整剤)を添加し、撹拌することで調製される。また、精製水にゲル基剤を分散させた液中に、エタノール等の分散剤、1,3−ブチレングリコール等の保湿剤を加え、均一に溶解させた後に、害虫忌避成分、紫外線劣化抑制成分、ゲル化剤を添加することで、パラメトキシ桂皮酸エチルヘキシル等の水溶性の低い有機化合物を紫外線劣化抑制成分として用いる場合にも、本発明のジェルタイプの人体用害虫忌避剤を容易に調製することができる。[Preparation method]
In the gel-type pest repellent for humans of the present invention, the gel base is dispersed in purified water, and the pest repellent components icaridin, IR3535, and / or p-menthane-3,8-diol are contained in this solution. It is prepared by adding ethylhexyl paramethoxycinnamate, which is an ultraviolet deterioration suppressing component, and mixing, then adding a gelling agent (pH adjuster) and stirring. Further, after adding a dispersant such as ethanol and a moisturizing agent such as 1,3-butylene glycol to a liquid in which a gel base is dispersed in purified water and uniformly dissolving the gel base, a pest repellent component and an ultraviolet deterioration suppressing component are added. By adding a gelling agent, the gel-type pest repellent for humans of the present invention can be easily prepared even when a low-water-soluble organic compound such as ethylhexyl paramethoxycinnamate is used as an ultraviolet deterioration inhibitory component. Can be done.
こうして得られた本発明のジェルタイプの人体用害虫忌避剤は、害虫忌避成分としてイカリジン、IR3535、及び/又はp−メンタン−3,8−ジオールを含有するため、従来のジェルタイプの人体用害虫忌避剤において害虫忌避成分として用いられていたディートよりも害虫忌避効力の持続性に優れ、さらに、塗布時に塗り延ばした手の平のべたつき感を素早く解消することができる。さらに、紫外線劣化抑制成分として、紫外線吸収性の高いパラメトキシ桂皮酸エチルヘキシルを含有するため、紫外線量の多い夏季の使用であっても、塗布後に紫外線の暴露によって害虫忌避成分が劣化することを抑制して忌避効力の持続性を向上させることができ、頻繁な塗り直しが必要になることを防ぐことができる。これらの結果、手の平にべたつき感のない状態が長く維持され、手の平のべたつき感により不便さが生じることを低減することができるため、使用者は本発明のジェルタイプの人体用害虫忌避剤をためらうことなく使用することができる。 Since the gel-type pest repellent for humans of the present invention thus obtained contains icaridin, IR3535, and / or p-menthane-3,8-diol as pest repellent components, conventional gel-type pests for humans It has a longer lasting pest repellent effect than DEET, which has been used as a pest repellent component in repellents, and can quickly eliminate the sticky feeling of the palm spread during application. Furthermore, since it contains ethylhexyl paramethoxycinnamate, which has high ultraviolet absorption, as an ultraviolet deterioration suppressing component, it suppresses the deterioration of the pest repellent component due to exposure to ultraviolet rays even when used in the summer when the amount of ultraviolet rays is large. Therefore, the sustainability of the repellent effect can be improved, and frequent repainting can be prevented. As a result, the non-sticky state of the palm can be maintained for a long time, and the inconvenience caused by the sticky feeling of the palm can be reduced. Therefore, the user hesitates to use the gel-type pest repellent for humans of the present invention. Can be used without.
本発明のジェルタイプの人体用害虫忌避剤(実施例1〜7)を調製し、これらの特性を測定及び評価した。また、本発明の範囲外となるジェルタイプの人体用害虫忌避剤(比較例1〜4)についても調製し、実施例と同様に特性の測定及び評価を行った。 Gel-type pest repellents for humans (Examples 1 to 7) of the present invention were prepared, and their characteristics were measured and evaluated. In addition, gel-type pest repellents for human bodies (Comparative Examples 1 to 4), which are outside the scope of the present invention, were also prepared, and their characteristics were measured and evaluated in the same manner as in Examples.
<実施例1>
表1の組成に従って、精製水にゲル基材としてカルボキシビニルポリマー(0.15重量部)を添加し、これを攪拌して分散状態とした液中に、エタノール(35重量部)、保湿剤として1,3−ブチレングリコール(5重量部)及び海藻エキス(1重量部)を添加し、液が均一になるまで攪拌した。その後、この液中に、害虫忌避成分としてイカリジン(5重量部)、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.15重量部)、ゲル化剤としてトリエタノールアミン(0.15重量部)を添加し、液がゲル状になるまで攪拌し、実施例1のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 1>
According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) was added to purified water as a gel base material, and this was stirred to make a dispersed state, and ethanol (35 parts by weight) was added as a moisturizer. 1,3-butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added, and the mixture was stirred until the liquid became uniform. Then, in this liquid, icaridine (5 parts by weight) as a pest repellent component, ethylhexyl paramethoxycinnamate (0.15 parts by weight) as an ultraviolet deterioration suppressing component, and triethanolamine (0.15 parts by weight) as a gelling agent were added. The mixture was added and stirred until the liquid became a gel to obtain a gel-type pest repellent for humans (100 parts by weight) of Example 1.
<実施例2>
表1の組成に従って、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.9重量部)を添加したこと以外は実施例1と同様の処方及び手順により、実施例2のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 2>
According to the composition of Table 1, the gel type pest repellent for human body of Example 2 was prepared according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (0.9 parts by weight) was added as an ultraviolet deterioration suppressing component. The agent (100 parts by weight) was obtained.
<実施例3>
表1の組成に従って、害虫忌避成分としてIR3535(5重量部)、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.3重量部)を添加したこと以外は実施例1と同様の処方及び手順により、実施例3のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 3>
According to the composition of Table 1, IR3535 (5 parts by weight) was added as a pest repellent component, and ethylhexyl paramethoxycinnamate (0.3 parts by weight) was added as an ultraviolet deterioration suppressing component, according to the same formulation and procedure as in Example 1. A gel-type pest repellent for humans (100 parts by weight) of Example 3 was obtained.
<実施例4>
表1の組成に従って、害虫忌避成分としてp−メンタン−3,8−ジオール(5重量部)、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.3重量部)を添加したこと以外は実施例1と同様の処方及び手順により、実施例4のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 4>
Example 1 except that p-menthane-3,8-diol (5 parts by weight) was added as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) was added as an ultraviolet deterioration suppressing component according to the composition shown in Table 1. The gel type pest repellent for human body (100 parts by weight) of Example 4 was obtained by the same formulation and procedure as in the above.
<実施例5>
表1の組成に従って、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.05重量部)を添加したこと以外は実施例1と同様の処方及び手順により、実施例5のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 5>
According to the composition of Table 1, the gel type pest repellent for human body of Example 5 was prepared according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (0.05 parts by weight) was added as an ultraviolet deterioration suppressing component. The agent (100 parts by weight) was obtained.
<実施例6>
表1の組成に従って、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(2.0重量部)を添加したこと以外は実施例1と同様の処方及び手順により、実施例6のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 6>
According to the composition of Table 1, the gel type pest repellent for human body of Example 6 was prepared according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (2.0 parts by weight) was added as an ultraviolet deterioration suppressing component. The agent (100 parts by weight) was obtained.
<実施例7>
表1の組成に従って、害虫忌避成分としてイカリジン(20重量部)、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.3重量部)を添加したこと以外は実施例1と同様の処方及び手順により、実施例7のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Example 7>
According to the composition of Table 1, according to the same formulation and procedure as in Example 1 except that icaridin (20 parts by weight) was added as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) was added as an ultraviolet deterioration suppressing component. A gel-type pest repellent for humans (100 parts by weight) of Example 7 was obtained.
<比較例1>
表1の組成に従って、精製水にゲル基材としてカルボキシビニルポリマー(0.15重量部)を添加し、これを攪拌して分散状態とした液中に、エタノール(35重量部)、保湿剤として1,3−ブチレングリコール(5重量部)及び海藻エキス(1重量部)を添加し、液が均一になるまで攪拌した。その後、この液中に、害虫忌避成分としてイカリジン(5重量部)、ゲル化剤としてトリエタノールアミン(0.15重量部)を添加し、液がゲル状になるまで攪拌し、比較例1のジェルタイプの人体用害虫忌避剤(100重量部)を得た。比較例1のジェルタイプの人体用害虫忌避剤は、紫外線劣化抑制成分を含まない処方である。<Comparative example 1>
According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) was added to purified water as a gel base material, and this was stirred to make a dispersed state, and ethanol (35 parts by weight) was added as a moisturizer. 1,3-butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added, and the mixture was stirred until the liquid became uniform. Then, icaridin (5 parts by weight) as a pest repellent component and triethanolamine (0.15 parts by weight) as a gelling agent were added to this liquid, and the mixture was stirred until the liquid became a gel, and compared with Comparative Example 1. A gel-type pest repellent for humans (100 parts by weight) was obtained. The gel-type pest repellent for humans of Comparative Example 1 is a formulation that does not contain an ultraviolet deterioration suppressing component.
<比較例2>
表1の組成に従って、精製水にゲル基材としてカルボキシビニルポリマー(0.15重量部)を添加し、これを攪拌して分散状態とした液中に、エタノール(35重量部)、保湿剤として1,3−ブチレングリコール(5重量部)及び海藻エキス(1重量部)を添加し、液が均一になるまで攪拌した。その後、この液中に、害虫忌避成分としてディート(5重量部)、紫外線劣化抑制成分としてパラメトキシ桂皮酸エチルヘキシル(0.2重量部)、ゲル化剤としてトリエタノールアミン(0.15重量部)を添加し、液がゲル状になるまで攪拌し、比較例2のジェルタイプの人体用害虫忌避剤(100重量部)を得た。比較例2のジェルタイプの人体用害虫忌避剤は、害虫忌避成分としてイカリジン、IR3535、又はp−メンタン−3,8−ジオールではなく、従来用いられていたディートを含む処方である。<Comparative example 2>
According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) was added to purified water as a gel base material, and this was stirred to make a dispersed state, and ethanol (35 parts by weight) was added as a moisturizer. 1,3-butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added, and the mixture was stirred until the liquid became uniform. Then, in this liquid, Diet (5 parts by weight) as a pest repellent component, ethylhexyl paramethoxycinnamate (0.2 parts by weight) as an ultraviolet deterioration suppressing component, and triethanolamine (0.15 parts by weight) as a gelling agent were added. The mixture was added and stirred until the liquid became a gel to obtain a gel-type pest repellent for humans (100 parts by weight) of Comparative Example 2. The gel-type pest repellent for humans of Comparative Example 2 is a formulation containing the conventionally used DEET as a pest repellent component instead of icaridin, IR3535, or p-menthane-3,8-diol.
<比較例3>
表1の組成に従って、害虫忌避成分としてイカリジン(20重量部)を添加したこと以外は比較例1と同様の処方及び手順により、比較例3のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Comparative example 3>
A gel-type pest repellent for humans (100 parts by weight) of Comparative Example 3 according to the same formulation and procedure as in Comparative Example 1 except that icaridin (20 parts by weight) was added as a pest repellent component according to the composition of Table 1. Got
<比較例4>
表1の組成に従って、害虫忌避成分としてイカリジン(30重量部)を添加したこと以外は比較例1と同様の処方及び手順により、比較例4のジェルタイプの人体用害虫忌避剤(100重量部)を得た。<Comparative example 4>
Gel-type pest repellent for humans (100 parts by weight) of Comparative Example 4 according to the same formulation and procedure as in Comparative Example 1 except that icaridin (30 parts by weight) was added as a pest repellent component according to the composition of Table 1. Got
実施例1〜7及び比較例1〜4のジェルタイプの人体用害虫忌避剤にかかる試料を調製し、夫々のジェルタイプの人体用害虫忌避剤の特性として、(1)粘度減衰率、(2)有効成分回収率、(3)乾燥時間、(4)濁度を測定した。各特性の測定方法について、以下に説明する。また、各試料の測定結果を表2に示す。 Samples for the gel-type pest repellents for humans of Examples 1 to 7 and Comparative Examples 1 to 4 were prepared, and the characteristics of the gel-type pest repellents for humans were (1) viscosity attenuation rate and (2). ) Active ingredient recovery rate, (3) drying time, and (4) turbidity were measured. The measuring method of each characteristic will be described below. Table 2 shows the measurement results of each sample.
(1)粘度減衰率
測定対象の試料をガラス製の容器に充填し、その状態で試料の粘度を測定し、これを初期粘度(A1)とした。次いで、この容器を遮光しない状態で屋外に一週間放置した後、再び試料の粘度を測定し、これを終期粘度(A2)とした。試料の粘度は、JIS Z 8803に準拠した方法により測定した。そして、以下の式(I)より、試料の粘度減衰率を求めた。
粘度減衰率(%) = |A2−A1|/A1 × 100 ・・・ (I)
また、実施例1のジェルタイプの人体用害虫忌避剤の粘度減衰率を1とし、各資料の粘度減衰率の相対比を算出した。(1) Viscosity Damping Factor The sample to be measured was filled in a glass container, and the viscosity of the sample was measured in that state, and this was taken as the initial viscosity (A1). Then, after leaving this container outdoors for one week without shading, the viscosity of the sample was measured again, and this was taken as the final viscosity (A2). The viscosity of the sample was measured by a method according to JIS Z 8803. Then, the viscosity attenuation rate of the sample was obtained from the following formula (I).
Viscosity decay rate (%) = | A2-A1 | / A1 x 100 ... (I)
Further, the viscosity attenuation rate of the gel-type pest repellent for human body of Example 1 was set to 1, and the relative ratio of the viscosity attenuation rates of each material was calculated.
(2)有効成分回収率
測定対象の試料をガラス製の容器に充填し、その状態で試料の害虫忌避成分(有効成分)の含有量を測定し、これを初期含有量(B1)とした。次いで、この容器を遮光しない状態で屋外に一週間放置した後、再び試料の害虫忌避成分の含有量を測定し、これを終期含有量(B2)とした。害虫忌避成分の含有量は、ガスクロマトグラフィー(株式会社島津製作所製、型式:GC14B)により測定した。そして、以下の式(II)より、試料の有効成分回収率を求めた。
有効成分回収率(%) = B2/B1 × 100 ・・・ (II)(2) Active ingredient recovery rate The sample to be measured was filled in a glass container, and the content of the pest repellent component (active ingredient) of the sample was measured in that state, and this was taken as the initial content (B1). Then, after leaving this container outdoors for one week without shading, the content of the pest repellent component of the sample was measured again, and this was defined as the final content (B2). The content of the pest repellent component was measured by gas chromatography (manufactured by Shimadzu Corporation, model: GC14B). Then, the active ingredient recovery rate of the sample was determined from the following formula (II).
Active ingredient recovery rate (%) = B2 / B1 x 100 ... (II)
(3)乾燥時間
JIS K 5600の第3部第2節に準拠し、以下の手順により試料の乾燥時間を測定した。初めに、正方形のガラス板(20cm×20cm)を2枚用意し、一方のガラス板には測定対象の試料(0.1g)を載せてガラス面全体に塗り伸ばし(試験区)、他方のガラス板は未処理のまま(対照区)としておく。試験区及び対照区のガラス板に発泡スチロール片(5mm×5mm×5mm)をそれぞれ10個ずつ散布し、ガラス板を垂直に立てて落下した発泡スチロール片の数をカウントする。この操作を1分毎に実施し、試験区及び対照区のガラス板から落下した発泡スチロール片の数が同じとなった時点を乾燥時間とした。(3) Drying time The drying time of the sample was measured according to the following procedure in accordance with Section 2 of Part 3 of JIS K 5600. First, prepare two square glass plates (20 cm x 20 cm), place the sample (0.1 g) to be measured on one glass plate, spread it over the entire glass surface (test plot), and spread the other glass. The board is left untreated (control plot). 10 pieces of Styrofoam pieces (5 mm × 5 mm × 5 mm) are sprayed on the glass plates of the test group and the control group, and the number of Styrofoam pieces dropped by standing the glass plates vertically is counted. This operation was carried out every minute, and the time when the number of Styrofoam pieces dropped from the glass plates of the test group and the control group became the same was defined as the drying time.
(4)濁度
第17改正日本薬局方・一般試験法 2.61濁度試験法の目視法に準拠し、試料の濁度を測定した。(4) Turbidity The turbidity of the sample was measured in accordance with the 17th revision of the Japanese Pharmacopoeia / General Test Method 2.61 Turbidity Test Method.
表2に示すように、実施例1〜4、6、7のジェルタイプの人体用害虫忌避剤は、粘度減衰率が5%以下に抑えられており、使用初期から使用終期まで安定した性状を維持するものであることから、使い勝手に優れるものであった。また、有効成分の減少も見られず、長期に亘って忌避効果を持続することが確認された。さらに、乾燥時間が11分以下であり、皮膚への塗布後、べたつき感を速やかに解消することが可能であった。実施例5のジェルタイプの人体用害虫忌避剤については、粘度の減衰が見られ、有効成分の若干の減少も見られたが、乾燥時間は11分であり、実用上問題の無いものであった。 As shown in Table 2, the gel-type pest repellents for human bodies of Examples 1 to 4, 6 and 7 have a viscosity attenuation rate of 5% or less, and have stable properties from the initial stage of use to the final stage of use. Since it was maintained, it was easy to use. In addition, no decrease in the active ingredient was observed, and it was confirmed that the repellent effect was maintained for a long period of time. Furthermore, the drying time was 11 minutes or less, and it was possible to quickly eliminate the sticky feeling after application to the skin. Regarding the gel-type pest repellent for human body of Example 5, the viscosity was attenuated and the active ingredient was slightly decreased, but the drying time was 11 minutes, which was not a problem in practical use. rice field.
これに対し、比較例1のジェルタイプの人体用害虫忌避剤は、粘度減衰率が約90%と非常に大きな値となり、安定した性状を維持することができなかった。これは、紫外線劣化抑制成分であるパラメトキシ桂皮酸エチルヘキシルを含んでいないため、人体用害虫忌避剤のゲル分子構造が紫外線により劣化し、破壊されたことに起因すると考えられる。また、パラメトキシ桂皮酸エチルヘキシルを含まない比較例1では、有効成分も若干減少する結果となり、忌避効果の持続性が懸念されるものであった。さらに、乾燥時間についても実施例1〜7より長くなっており、皮膚への塗布後、べたつき感を速やかに解消することができず使い勝手が悪いものであった。 On the other hand, the gel-type pest repellent for human body of Comparative Example 1 had a very large viscosity attenuation rate of about 90%, and could not maintain stable properties. It is considered that this is because the gel molecular structure of the pest repellent for humans is deteriorated and destroyed by ultraviolet rays because it does not contain ethylhexyl paramethoxycinnamate, which is an ultraviolet deterioration suppressing component. Further, in Comparative Example 1 containing no ethylhexyl paramethoxycinnamate, the active ingredient was also slightly reduced, and there was concern about the persistence of the repellent effect. Further, the drying time was longer than that of Examples 1 to 7, and after application to the skin, the sticky feeling could not be promptly eliminated, resulting in poor usability.
害虫忌避成分としてディートを含む比較例2のジェルタイプの人体用害虫忌避剤に関しては、粘度減衰率が10%を超えており、安定した性状を維持することは困難であった。また、乾燥時間に13分を要しており、皮膚への塗布後、べたつき感を速やかに解消することができず使い勝手が悪いものであった。 Regarding the gel-type pest repellent for humans of Comparative Example 2 containing DEET as a pest repellent component, the viscosity attenuation rate exceeded 10%, and it was difficult to maintain stable properties. In addition, it took 13 minutes to dry, and after application to the skin, the sticky feeling could not be quickly eliminated, resulting in poor usability.
比較例3のジェルタイプの人体用害虫忌避剤は、害虫忌避成分としてイカリジンを20重量%含むものであるが、紫外線劣化抑制成分であるパラメトキシ桂皮酸エチルヘキシルを含んでいないため、比較例1と同様に粘度減衰率が非常に大きな値(約80%)となり、安定した性状を維持することができなかった。また、有効成分が減少していることから、忌避効果の持続性が懸念されるものであった。さらに、乾燥時間についても14分を要しており、皮膚への塗布後、べたつき感を速やかに解消することができず使い勝手が悪いものであった。 The gel-type pest repellent for humans of Comparative Example 3 contains 20% by weight of icaridin as a pest repellent component, but does not contain ethylhexyl paramethoxycinnamate, which is an ultraviolet deterioration suppressing component, and therefore has the same viscosity as Comparative Example 1. The attenuation rate became a very large value (about 80%), and stable properties could not be maintained. In addition, since the active ingredient was reduced, there was concern about the sustainability of the repellent effect. Further, it took 14 minutes to dry, and after application to the skin, the sticky feeling could not be quickly eliminated, which was not easy to use.
比較例4のジェルタイプの人体用害虫忌避剤は、害虫忌避成分としてイカリジンを過剰量(30重量%)含むことで、有効成分の顕著な減少や、乾燥時間の長期化が見られた。また、紫外線劣化抑制成分であるパラメトキシ桂皮酸エチルヘキシルを含んでいないため、比較例1と同様に粘度減衰率が非常に大きな値(約80%)となり、安定した性状を維持することができなかった。 The gel-type pest repellent for human body of Comparative Example 4 contained an excessive amount (30% by weight) of icaridin as a pest repellent component, so that a remarkable decrease in the active ingredient and a prolongation of the drying time were observed. In addition, since it does not contain ethylhexyl paramethoxycinnamic acid, which is an ultraviolet deterioration suppressing component, the viscosity attenuation rate becomes a very large value (about 80%) as in Comparative Example 1, and stable properties could not be maintained. ..
本発明のジェルタイプの人体用害虫忌避剤は、蚊、ブヨ、アブ、マダニ、サシバエ、イエダニ、ナンキンムシ、ヌカカ、ヤマビル等の刺咬害虫による刺咬被害を防ぐ用途に利用可能である。 The gel-type pest repellent for humans of the present invention can be used for preventing bite damage caused by biting pests such as mosquitoes, gnats, bugs, ticks, stable flies, house mites, bed bugs, biting bugs, and yamabil.
Claims (11)
ゲル基剤と、ゲル化剤と、害虫忌避成分と、紫外線劣化抑制成分と、水とを含み、
前記害虫忌避成分は、2−(2−ヒドロキシエチル)−1−ピペリジンカルボン酸1−メチルプロピルエステル、3−(N−n−ブチル−N−アセチル)アミノプロピオン酸エチルエステル、及びp−メンタン−3,8−ジオールからなる群から選択される少なくとも一つであり、
前記紫外線劣化抑制成分は、パラメトキシ桂皮酸エチルヘキシルであり、
前記紫外線劣化抑制成分の含有量は、0.1〜1.0重量%であり、
前記ゲル基剤の含有量は、0.05〜0.5重量%であるジェルタイプの人体用害虫忌避剤。 A water-soluble gel-type pest repellent for humans
Contains a gel base, a gelling agent, a pest repellent component, an ultraviolet deterioration suppressing component, and water.
The pest repellent components are 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionate ethyl ester, and p-menthane-. At least one selected from the group consisting of 3,8-diols
The ultraviolet deterioration suppressing component, Ri paramethoxy Ethylhexyl der,
The content of the ultraviolet deterioration suppressing component is 0.1 to 1.0% by weight.
A gel-type pest repellent for humans in which the content of the gel base is 0.05 to 0.5% by weight.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018000473 | 2018-01-05 | ||
JP2018000473 | 2018-01-05 | ||
PCT/JP2018/048049 WO2019135382A1 (en) | 2018-01-05 | 2018-12-27 | Gel-type pest repellent for use on human body |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2019135382A1 JPWO2019135382A1 (en) | 2020-11-26 |
JP6960471B2 true JP6960471B2 (en) | 2021-11-05 |
Family
ID=67144162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019563971A Active JP6960471B2 (en) | 2018-01-05 | 2018-12-27 | Gel-type pest repellent for humans |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP6960471B2 (en) |
CN (1) | CN111479468B (en) |
AU (1) | AU2018400018A1 (en) |
TW (1) | TWI724358B (en) |
WO (1) | WO2019135382A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3763212B1 (en) | 2019-07-11 | 2021-08-18 | SanderStrothmann GmbH | Arthropoda repellent composition |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05331033A (en) * | 1992-05-25 | 1993-12-14 | Osaka Seiyaku:Kk | Gelatinous insect repellent |
JP2003171204A (en) * | 2001-12-04 | 2003-06-17 | Kowa Co | Gel-like insect repellent formulation |
JP2003171205A (en) * | 2001-12-04 | 2003-06-17 | Kowa Co | Gel-like insect repellent formulation |
JP4836169B2 (en) * | 2005-08-01 | 2011-12-14 | 大日本除蟲菊株式会社 | Gel pest repellent composition for human body |
US20070264294A1 (en) * | 2006-05-10 | 2007-11-15 | Lance-Gomez Edward T | Insect control compositions |
JP2009126804A (en) * | 2007-11-21 | 2009-06-11 | Dainippon Jochugiku Co Ltd | Noxious insect repellent for human body |
PT3056192T (en) * | 2015-02-16 | 2019-02-27 | Frezyderm S A | Complete anhydrous sunscreen composition with under water technology |
-
2018
- 2018-12-27 AU AU2018400018A patent/AU2018400018A1/en not_active Abandoned
- 2018-12-27 WO PCT/JP2018/048049 patent/WO2019135382A1/en active Application Filing
- 2018-12-27 JP JP2019563971A patent/JP6960471B2/en active Active
- 2018-12-27 CN CN201880080972.2A patent/CN111479468B/en active Active
-
2019
- 2019-01-03 TW TW108100142A patent/TWI724358B/en active
Also Published As
Publication number | Publication date |
---|---|
WO2019135382A1 (en) | 2019-07-11 |
TW201929664A (en) | 2019-08-01 |
TWI724358B (en) | 2021-04-11 |
CN111479468B (en) | 2022-06-17 |
JPWO2019135382A1 (en) | 2020-11-26 |
AU2018400018A1 (en) | 2020-07-02 |
CN111479468A (en) | 2020-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU1317299A (en) | Alcohol based anti-microbial compositions with cosmetic appearance | |
JP2011042680A (en) | Hydroalcoholic composition thickened using polymer | |
JP5057856B2 (en) | Pest repellent for human body | |
JP2006513194A (en) | Self-adhesive polymer matrix containing seaweed extract and glycerin | |
TWI662895B (en) | Insect pest repellent composition in powder form, and method for producing same | |
TWI705763B (en) | Insect pest repellent and insect pest repellent product | |
JP2009126804A (en) | Noxious insect repellent for human body | |
JP4836169B2 (en) | Gel pest repellent composition for human body | |
JP6960471B2 (en) | Gel-type pest repellent for humans | |
JP6814048B2 (en) | Flying pest repellent adhesive sticker | |
US8114386B2 (en) | Topical insect repellent composition and method of application | |
CN110583715A (en) | Mosquito repellent containing synergist | |
US11123282B2 (en) | Formulations with a controlled release of perfumes for dermal application | |
US6210688B1 (en) | Use of polymers as film-forming barrier materials | |
JPH10182304A (en) | Mothproofing agent | |
TWI845581B (en) | Pest repellent composition | |
JP2023103650A (en) | Insect pest repellent for human body | |
JP4846300B2 (en) | Pest repellent for human body | |
KR20110059060A (en) | Rodent repellent composition | |
JP4460261B2 (en) | Pest repellent composition for human body | |
JP2007063185A (en) | Powdery pest-repelling composition | |
DE102005012473A1 (en) | Composition, useful for preparing cosmetic agents/medicament to treat discoloration of nails, comprises active agent against microorganisms, alpha-cyanoacrylate and usual additives for cyanoacrylate adhesives | |
JP2021116304A (en) | Pest repellent and method for improving feel of pest repellent component | |
JP2005008832A (en) | Transparent gel-like composition and transparent gel-like fragrance composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200605 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210803 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20210901 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210907 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211005 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211011 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6960471 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |