TWI662895B - Insect pest repellent composition in powder form, and method for producing same - Google Patents

Abstract

The form of the pest repellent product is powder-based, and it provides a non-alcoholic powdery pest repellent composition, which is of course excellent in pest repellent effect and excellent in safety to humans or animals. .

A powdery pest repellent composition comprising: a member selected from the group consisting of insecticide decamethoxamine, 3- (N-n-butyl-N-ethylamido) aminopropionate, and ecaridine At least one pest repellent as an active ingredient; a stimulus mitigating agent using an ethylene glycol-based solvent as an active ingredient; a moisture retaining agent using talc as an active ingredient; and an oil content absorbent containing a silicic acid compound as an active ingredient; the aforementioned moisture The ratio (a: b) of the blending amount (a) of the retaining agent to the blending amount (b) of the oil component absorbent is 15: 1 to 19: 1 in a weight ratio.

Description

Use of powdery insect repellent composition and its manufacturing method

The invention relates to a powdery pest repellent composition for protecting a human body or an animal from pests such as mosquitoes, maggots, fly maggots, house dust mites, bed bugs, and the like, and a manufacturing method thereof.

Conventional pest repellent products are aerosol-type products using alcohol as a base. For example, Patent Literature 1 and Patent Literature 2 are known as conventional spray can type insect repellent products. The pest repellent composition of Patent Document 1 mixes inorganic powder or organic powder with anhydrous silicic acid at a specific ratio, and fills the spray can container with the pest repellent component, alcohol, and propellant. In the repellent composition of Patent Document 2, a pest repellent is supported on porous fine particles of anhydrous silicic acid, and the spray can container is filled with the synthetic resin fine particles, alcohol, and a propellant. Further, as a pest repellent product other than the spray tank type, a wet tissue type product such as Patent Document 3 has been developed. In the pest repellent of Patent Document 3, a non-woven fabric is impregnated with a silicic acid compound, a pest repellent component, and alcohol.

[Patent Document 1]: Japanese Unexamined Patent Publication No. 11-302102

[Patent Document 2]: Japanese Patent Laid-Open No. 2000-63201

[Patent Document 3]: Japanese Patent Laid-Open No. 2001-270802

However, spray can-type pest repellent products such as those in Patent Documents 1 and 2 have a micronization of the pest repellent component and sprayed it to the skin surface, so that uneven coating on the coated surface is likely to occur. As a result, a slight portion where the medicine is not adhered to the skin may be generated, and there is a possibility that a mosquito bite or blood sucking action may be caused in the small portion. In addition, the nasal mucosa is often irritated by the scattering of a pest repellent composition (medicine) containing alcohol or a pest repellent component, and improvement in use is required in this regard. Since the pest repellent of Patent Document 3 is not a spray tank type, there are few problems of scattering of the medicine. However, since alcohol is used in the same manner as the pest repellent products of Patent Documents 1 and 2, it is suitable for people who are allergic to the irritation of alcohol or the like. Language is still difficult to use.

For this reason, recently, it has been required that the medicine should not be scattered easily, and the demand for pest repellent products of the type not using alcohol is increasing. The present invention has been made in view of the above-mentioned problems. The product form of the pest repellent composition is focused on the powder form, and its purpose is to provide a natural pest repellent effect and excellent safety to humans or animals. The alcohol-free powdery pest repellent composition and its production method are also satisfactory in this respect.

The powdery pest repellent composition related to the present invention for solving the above-mentioned problems is characterized in that the use of the powdery pest repellent composition is to obtain a moist touch and contains: Amine (DEET), 3- (N-n-butyl-N-ethylfluorenyl) amine At least one of the group consisting of 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester and icaridin as a pest repellent as an active ingredient; ethylene glycol (glycol) is a stimulus mitigating agent with a solvent as an active ingredient; a moisture retention agent with talc as an active ingredient; and an oil content absorbent with anhydrous silicic acid as an active ingredient. A ratio (a: b) of the blending amount (b) of the oil component absorbent is 15: 1 to 19: 1 in a weight ratio.

The powdery insect repellent composition according to the present composition includes the moisture retaining agent containing talc as an active ingredient and the oil absorbent containing silicic acid compound as an active ingredient at the appropriate mixing ratio. Therefore, the user will use the powdery pest Avoid applying the composition to the skin, because oil such as sebum is moderately absorbed by the silicic acid compound, and at the same time, talc moderately retains moisture while suppressing stickiness while obtaining a moist touch. In addition, because talc and silicic acid compounds are stable substances, there is no risk of reducing the effect of the pest repellent, and it can be supplemented with the effect of the stimulant depressant to become a product with a low irritation and repellent effect.

In the use of the powdery pest repellent composition related to the present invention, the ethylene glycol-based solvent is preferably 1,3-butylene glycol.

The powdery pest repellent composition according to the present structure, by using 1,3-butanediol as an ethylene glycol-based solvent, can achieve an excellent feeling of use, and can particularly improve the irritation-reducing effect.

In powdery insect repellent composition related to the present invention In applications, the apparent specific gravity of the talc measured in accordance with JIS K5101 is preferably 0.4 to 0.6 g / cc.

The powdery pest repellent composition according to the present configuration has a specific gravity of talc in the above-mentioned appropriate range, so that the water is moderately held by the talc and a more moist feeling can be obtained.

In the use of the powdery pest repellent composition according to the present invention, it is preferable that the talc has an average particle diameter of 20 μm or more.

The powdery insect repellent composition according to the present composition has an average particle diameter of talc of 20 μm or more, so that the talc can be reliably adhered to the skin, and a more moist feeling can be obtained.

In the use of the powdery insect repellent composition related to the present invention, the aforementioned silicic acid compound is preferably anhydrous silicic acid.

The powdery insect repellent composition according to the present structure, by using anhydrous silicic acid as a silicic acid compound, makes oil absorption particularly good, and it is an effective product that can reduce stickiness for people with a lot of sebum .

In the use of the powdery pest repellent composition related to the present invention, the specific surface area of the silicic acid compound is preferably 5 to 100 m ² / g.

The powdery pest repellent composition according to the present configuration has a specific surface area of the silicic acid compound in the above-mentioned appropriate range, and can efficiently absorb oil such as sebum.

In the use of the powdery pest repellent composition related to the present invention, it is preferable not to include alcohol.

The powdery pest repellent composition according to this constitution does not contain alcohol, so that it can be used safely even by people who are allergic to irritation.

The method for producing a powdery pest repellent composition related to the present invention for solving the above-mentioned problems is characterized in that a method for producing a powdery pest repellent composition is used to obtain the wetness of the powdery pest repellent composition. Tactile sensation, comprising: using at least one selected from the group consisting of decalin, 3- (N-n-butyl-N-ethylamido) aminopropionate, and ecaridine Pest repellent of active ingredients, and a mixing procedure for mixing a stimulus mitigating agent using an ethylene glycol-based solvent as an active ingredient; absorption of the mixture obtained by the foregoing mixing procedure into an oil component absorbent containing a silicic acid compound as an active ingredient Procedures; adding a water retaining agent with talc as an active ingredient to the oil component absorbent adding procedure after the absorption procedure is completed; and a stirring procedure for stirring the mixture of each component obtained by the foregoing adding procedure; The ratio (a: b) of the added amount (a) of the moisture retaining agent to the used amount (b) of the oil component absorbent in the absorption procedure is a weight ratio of 15: 1 to 19: 1.

According to the manufacturing method of the powdery pest repellent composition of this structure, the same excellent effect as the above-mentioned powdery pest repellent composition can be achieved. In other words, the amount of the water-retaining agent using talc as an active ingredient in the adding process and the amount of the oil-absorbing agent using the silicic acid compound as an active ingredient in the absorption process are set to be appropriate as described above. Weight ratio, so as soon as the user applies the powdery pest repellent composition obtained after the subsequent stirring procedure to the skin, the oil content such as sebum is moderately absorbed by the silicic acid compound, while talc moderately retains moisture while suppressing hair Sticky while getting a moist touch. In addition, because talc and silicic acid compounds are stable substances, there is no risk of reducing the effect of the insect repellent, and it can be supplemented with the effect of the stimulus mitigant to produce a product with a low irritation and repellent effect.

The powdery pest repellent composition of the present invention contains (1), a pest repellent, (2), a stimulus mitigating agent, (3), a moisture retaining agent, and (4), an oil content absorbent as basic components. On the other hand, the powdery pest repellent composition of the present invention does not contain alcohols such as ethanol, isopropanol, and propanol. Hereinafter, each component of the powdery pest repellent composition of this invention is demonstrated in detail.

(1) Pest repellent

A pest repellent is a substance that has a repellent effect or a blood sucking inhibitory effect on pests. Examples of the insect repellent include deuterantamine, ethyl 3- (N-n-butyl-N-ethylammonium) aminopropionate, ecaride, picaridin, and fragrance. Citronellal, citronellol, citral, linalool, terpineol, menthol, p-menthane-3,8-diol (p -menthane-3,8-diol), α-pinene, camphor, geraniol, carane-3,4-diol ) And other synthetic compounds. Also, cinnamon, citronella, lemongrass, clover can be used (clover), bergamot, laurel, eucalyptus and other natural products. Natural products can be used in the form of essential oils or extracts. Among the pest repellents listed above, decalin, ethyl 3- (N-n-butyl-N-ethylamido) aminopropionate, and ecaride are suitable for use. DEET has been used for many years. Ethyl 3- (N-n-butyl-N-ethylammonium) aminopropionate has a repellent effect approximately equal to that of DEET, and at the same time, it is safer than DEET. Ecaridine has high pest repellent effect and high safety. In addition, each of the pest repellents listed above may be used alone or as a mixture of two or more. The compounding amount of the pest repellent is 1 to 15% by weight, preferably 3 to 14% by weight, and more preferably 6 to 12% by weight based on the entire amount of the powdery insect repellent composition. When the compounding amount is less than 1% by weight, a sufficient pest repellent effect may not be obtained. When the compounding amount is more than 15% by weight, there is a possibility that the stimulation may be excessive.

(2) Stimulant

A stimulant is a substance added to alleviate skin irritation caused by a pest repellent. An ethylene glycol-based solvent was used as a stimulant. The ethylene glycol solvent is preferably C ₃ to C ₆ ethylene glycol, and examples thereof include diethylene glycol, propylene glycol, dipropylene glycol, and 1,3-butane. Diol (1,3-butylene glycol) and the like. Of these, 1,3-butanediol, which has a high stimulating and alleviating effect, is more suitable for use. Incidentally, ethylene glycol of C ₃ to C ₆ including 1,3-butanediol is difficult to be absorbed from the skin by itself, so it is also effective for reducing the percutaneous absorption of insect repellents. The ethylene glycol solvents listed above may be used alone or as a mixture of two or more. The blending amount of the stimulus mitigating agent is 1 to 15% by weight, preferably 5 to 10% by weight, and more preferably 6 to 8% by weight, based on the total amount of the powdery insect repellent composition. When the blending amount is less than 1% by weight, the irritation of the insect repellent may not be sufficiently mitigated. When the compounding amount is more than 15% by weight, a large amount of the ethylene glycol-based solvent may increase the sticky feeling, and the use feeling may deteriorate.

(3) Moisture retaining agent

The moisture retaining agent is a substance added to give a moist touch (so-called moist feeling). Use talc as a moisture retention agent. The apparent specific gravity of talc measured in accordance with JIS K5101 is preferably 0.4 to 0.6 g / cc. When the specific gravity is less than 0.4 g / cc, the sticky feeling is more strongly felt than the wet feeling, and the feeling of use tends to deteriorate. When the specific gravity exceeds 0.6 g / cc, the dry feeling becomes stronger, and there is a possibility of powder falling. The average particle diameter of the talc is preferably 20 μm or more. With an average particle diameter of 20 μm or more, talc can be reliably adhered to the skin, and a more moist feeling can be obtained. When the average particle diameter is less than 20 μm, the pest avoids the composition from being white when applied to the skin, and it is remarkable, and a so-called white residue may be generated. In addition, talc can also be used in a state of being mixed with other inorganic powders such as kaolin and bentonite. The amount of the water retaining agent is 50 to 90% by weight, preferably 55 to 85% by weight, and more preferably 63 to 83.5% by weight, based on the total amount of the powdery insect repellent composition. When the blending amount is less than 50% by weight, moisture may not be sufficiently retained, and powder fall may occur. When the blending amount is more than 90% by weight, the sticky feeling is more strongly felt than the moist feeling, and the use feeling tends to deteriorate.

(4) Oil absorbent

The oil component absorbent is a substance added to absorb oil components such as sebum. Use silicic acid compound as oil absorbent. Examples of the silicic acid compound include anhydrous silicic acid, calcium silicate, hydrophobic silica, and diatomaceous earth. Among them, anhydrous silicic acid with high oil absorption effect is more suitable for use. The specific surface area of the silicic acid compound is preferably 5 to 100 m ² / g. When the specific surface area is less than 5 m ² / g, the oil absorption capacity is insufficient to cause stickiness. When the specific surface area exceeds 100 m ² / g, the dry feeling becomes stronger, and there is a possibility of powder falling. In addition, the above-mentioned silicic acid compounds may be used alone or in a mixture of two or more. The amount of the oil component absorbent is 1 to 50% by weight, preferably 3 to 30% by weight, and more preferably 4.5 to 21% by weight, based on the total amount of the powdery insect repellent composition. When the blending amount is less than 1% by weight, the oil absorption capacity is insufficient, and stickiness is liable to occur. When the blending amount is more than 50% by weight, the oil content absorption capacity becomes excessive, and the feeling of heavyness and useability tend to deteriorate.

The powdery pest repellent composition of the present invention uses (1), a pest repellent, (2), a stimulus mitigator, (3), a moisture retaining agent, (4), and an oil content absorbent as raw materials. It is manufactured by the following procedure.

First, a pest repellent and a stimulus mitigating agent are mixed (mixing procedure). Next, the mixture obtained by the mixing procedure is absorbed in an oil content absorbent (absorption procedure). Furthermore, a water-retaining agent is added to the oil-absorbent which has completed the absorption process (addition process). Finally, the mixture of each component obtained by the addition procedure is stirred (stirring procedure). This completes the powdery pest repellent composition of the present invention.

Here, the mixing amount of each component of the powdery pest repellent composition was determined by the present inventors through trial and error. In order to ensure the pest repellent effect and the safety to humans or animals, it was considered as a feeling of use. For products with excellent durability, it is important to set the blending amount of the moisture retaining agent and the blending amount of the oil component absorbent among the above-mentioned components to an appropriate ratio. Specifically, let the compounding amount (addition amount) of the moisture retaining agent be a, and let the compounding amount (use amount) of the oil absorbent be b, then the ratio of the blending amount of the moisture retaining agent to the blending amount of the oil absorbent (a: b ) Is set to a weight ratio of 3: 1 to 20: 1, preferably 3: 1 to 19: 1. When the compounding ratio is smaller than 3: 1, that is, when the compounding amount of the moisture retaining agent is much smaller than the compounding amount of the oil component absorbent, the powder may fall due to insufficient moisture retention. When the compounding ratio is larger than 20: 1, that is, when the compounding amount of the moisture retaining agent is far greater than the compounding amount of the oil content absorbent, the sticky feeling is more strongly felt than the moist feeling, and the use feeling tends to deteriorate. If the compounding ratio is set to the above-mentioned appropriate range, as soon as the user applies the powdery insect repellent composition to the skin, the oil content such as sebum is moderately absorbed by the silicic acid compound, while talc moderately retains moisture and suppresses hair development. Sticky while getting a moist touch. In addition, because talc and silicic acid compounds are stable substances, there is no risk of reducing the effect of the pest repellent, and it can be supplemented with the effect of the stimulant depressant to become a product with a low irritation and repellent effect.

The powdery pest repellent composition of the present invention may include other components as long as it does not inhibit the effects of the pest repellent, the stimulant depressant, the moisture retaining agent, and the oil absorbent. Examples of such components include ultraviolet absorbers, ultraviolet scattering agents, gloss agents, other powders, anti-inflammatory agents, antiperspirants, humectants, surfactants, dispersants, perfumes, and the like.

Examples of the ultraviolet absorber and ultraviolet scattering agent include: P-aminobenzoic acid, amyl salicylate, octyl cinnamate, octyl methoxycinnamate, 2,4-dihydroxybenzophenone ( 2,4-dihydroxybenzophenone), titanium oxide, zinc oxide, etc. Examples of the anti-inflammatory agent include dipotassium glycyrrhizinate, allantoin, alkyl trimethyl ammonium chloride, tocopherol acetate, and camphor )Wait. Examples of the antiperspirant include aluminum sulfate, chlorohydroxy aluminum, zinc phenolsulfonate, and the like. Examples of the gloss agent include a film (for example, a film in which aluminum is vapor-deposited on polyethylene terephthalate, a film in which gold is vapor-deposited on polyethylene terephthalate, and polyterephthalate Laminated film of ethylene acid and polyolefin, laminated film of polyethylene terephthalate and polymethyl methacrylate, polyethylene terephthalate and polyethylene (polyethylene laminated film) thin sections; natural mica powder such as muscovite powder, phlogopite powder; synthetic mica powder obtained by melting natural mica powder to remove impurities; titanium dioxide mixed with mica powder Minerals; Polyethylene glycol esters such as ethylene glycol monostearate, ethylene glycol distearate, triethylene glycol distearate, etc. Category; pigmented arugula capsules, etc. Furthermore, organic powders such as modified starch and silk fiber powder can also be added to the powdery pest repellent composition.

The powdery pest repellent composition of the present invention thus obtained becomes a bite to pests (especially mosquitoes, maggots, midges, house dust mites, bed bugs, etc.) Pests) have a high repellent effect, and at the same time, they have excellent safety to humans or animals. Pest repellent products are also satisfactory in terms of feeling of use or persistence. In addition, since the powdery pest repellent composition of the present invention does not use alcohol at all, it can be used safely even by people who are allergic to alcohol or the like.

[Example]

In order to confirm the effectiveness of the powdery pest repellent composition of the present invention, the blending of various pest repellents, stimulants, moisture retaining agents, and oil absorbents was changed to prepare powdery pest repellent compositions (Examples 1 to 11, Comparative Examples) 1 to 3), each composition was used to carry out a pest repellent effect confirmation test (initial period, after a certain period of time has elapsed) and a functional test (tacky feeling, moist feeling).

<Preparation of powdery pest repellent composition>

First, a mixture of a pest repellent and a stimulant is prepared, and the mixture is absorbed in an oil content absorbent. Then, a moisture retaining agent was further added and the mixture was sufficiently mixed to obtain powdery pest repellent compositions related to Examples 1 to 11 and Comparative Examples 1 to 3. Table 1 shows the compounding (part by weight) of the insect repellent, stimulus mitigating agent, moisture retaining agent, and oil absorbent in each Example and Comparative Example.

[Table 1]

Use insect repellent, ecaridine, or 3- (N-n-butyl-N-ethylamido) aminopropionate as a pest repellent.

As a stimulant, 1,3-butanediol was used.

Use talc as a moisture retention agent.

Anhydrous silicic acid (trade name: CARPLEX (registered trademark) 80, manufactured by Degussa Japan Co., Ltd.) was used as an oil content absorbent.

<Verification Test of Pest Repellent Effect>

Twenty female adults of Culex pipiens pallens were released into a box having a closable opening, and powdered pest repellent compositions related to Examples 1 to 11 and Comparative Examples 1 to 3 (2 g each) were applied through the openings. ) One arm of the subject was inserted into the box, and the number of Culex pipiens pallens attached to one arm of the subject was counted (n ₁ ). In addition, one arm of the subject who was not coated with the powdery pest repellent composition was inserted into a box of the same conditions as a blank, and the Culex pipiens pallens attached to one arm of the subject was similarly calculated. Number (n ₀ ). Then the avoidance rate of Culex pipiens pallens was calculated as (n ₀ -n ₁ ) / n ₀ [%]. The calculation of the repellent rate was performed immediately after the powdered insect repellent composition was used (just after the test was started) and after 4 hours from the start of use. Table 2 shows the results of the insect repellent effect confirmation test.

<Functional test>

The powdery pest repellent compositions related to Examples 1 to 11 and Comparative Examples 1 to 3 were applied to the skin of a panelist of 10 people, and the usability was evaluated in five stages. The evaluation criteria are as follows, and the average value of the evaluation points of a group of 10 members is used.

[Sticky]

5: No stickiness was felt at all.

4: Tackiness is slightly felt.

3: Slight stickiness is felt.

2: Feeling sticky.

1: Very sticky.

[Wet feeling]

5: Very moist.

4: Moist.

3: Slightly moist.

2: Slightly moist.

1: No wet feeling at all.

The results of the functional test are shown in Table 3.

From the results of the insect repellent effect confirmation test, the powdery insect repellent compositions related to Examples 1 to 11 and Comparative Examples 1 to 3 were confirmed to have sufficient repellent effects immediately after use. However, if After 4 hours, the powdery pest repellent composition related to Examples 1 to 11 showed almost no reduction in the repellent effect. It is a powdery pest repellent composition having a persistent powdery composition, and the powders related to Comparative Examples 1 to 3 The reduction of the repellent effect was confirmed by the pest-like repellent composition. In addition, the reduction in the repellent effect becomes significant over time (data omitted).

Regarding the results of the functional test, the powdery pest repellent composition related to Examples 1 to 11 had a high evaluation of both [sticky feeling] and [wet feeling] (that is, less sticky feeling, (Wet feeling), but the powdery pest repellent composition related to Comparative Examples 1 to 3 cannot coexist [sticky feeling] and [wet feeling], and the evaluation point itself is also low.

From the above results, the powdery pest repellent composition of the present invention is excellent in the feeling of use and durability, and does not contain alcohol at all, so it is obviously useful as a pest repellent product that is easy to use even for people who are allergic to irritation.

The powdery pest repellent composition of the present invention can be used as a pest repellent product for humans or pets, and other uses can also be used in applications such as insecticidal, acaricidal, bactericidal, antibacterial, deodorant, and deodorant.

Claims (7)

The utility model relates to a powdery insect repellent composition, which is used for obtaining a moist touch, and contains: selected from the group consisting of DEET, 3- (N-n-butyl-N-ethylamido) amine group At least one of the group consisting of ethyl propionate and icaridin as a pest repellent as an active ingredient; a stimulus mitigating agent using an ethylene glycol-based solvent as an active ingredient; and moisture retention using talc as an active ingredient And an oil content absorbent using anhydrous silicic acid as an active ingredient, and the ratio (a: b) of the blending amount (a) of the moisture retaining agent to the blending amount (b) of the oil content absorbent is 15: 1 by weight ~ 19: 1. For example, the application of the powdery insect repellent composition in the scope of the patent application item 1, wherein the ethylene glycol solvent is 1,3-butanediol. For example, the application of the powdery insect repellent composition in the first or second scope of the patent application, wherein the apparent specific gravity of the talc measured in accordance with JIS K5101 is 0.4 to 0.6 g / cc. For example, the application of the powdery pest repellent composition in the first or second scope of the patent application, wherein the talc has an average particle size of 20 μm or more. For example, the use of the powdery insect repellent composition in the first or second scope of the patent application, wherein the silicic acid compound has a specific surface area of 5 to 100 m ² / g. For example, the application of the powdery pest repellent composition of the first or second scope of the patent application does not include alcohol. A method for manufacturing a powdery insect repellent composition, which is used to obtain the wet feel of the powdery insect repellent composition. The method includes: selecting from the group consisting of DEET, 3- (N-n-butyl) -N-ethenyl) amino propionate and ecaridine are used as a pest repellent with at least one active ingredient, and a stimulant mitigating agent using an ethylene glycol-based solvent as an active ingredient. A mixing procedure; an absorption procedure in which the mixture obtained by the mixing procedure is absorbed in an oil component absorbent containing a silicic acid compound as an active ingredient; a moisture retaining agent with talc as an active component is added to the oil component absorbent after the absorption procedure is completed An adding program; and a stirring program for stirring the mixture of the components obtained by the adding program, the amount of the water-retaining agent added in the adding program (a), and the amount of the oil-absorbing agent used in the absorption program. The ratio (b) (a: b) is 15: 1 to 19: 1 by weight.