CN116251141A - Traditional Chinese medicine composition for dispelling wind-cold and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for dispelling wind-cold and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for dispelling wind-cold, which comprises the following main active components in parts by mass: 5-10 parts of ephedra herb, 10-15 parts of divaricate saposhnikovia root, 15-20 parts of notopterygium root, 15-20 parts of perilla leaf, 5-10 parts of dahurian angelica root, 5-10 parts of bitter apricot seed, 10-15 parts of platycodon root, 15-20 parts of aster and 15-20 parts of peucedanum root. The traditional Chinese medicine composition for dispelling wind-cold provided by the invention has the effects of dispelling wind-cold, eliminating phlegm and relieving cough, and can be effectively used for treating symptoms such as aversion to cold, fever, headache, body pain, nasal obstruction, clear nasal discharge, hyposmia, cough with thin white sputum, thin and white tongue fur, floating and tense pulse and the like after novel coronavirus infection.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for dispelling wind-cold and application thereof.
Background
In the prevention and treatment process of the novel coronavirus, the traditional Chinese medicine shows remarkable advantages. In the current diagnosis and treatment scheme of novel coronavirus infection, the prescription for treating patients with novel coronavirus infection is mostly focused on treating the novel coronavirus infection with symptoms of epidemic toxin exterior syndrome, cold-dampness depressed lung syndrome and damp-heat accumulated lung syndrome, and the prescription for targeted treatment of patients with symptoms of aversion to cold, fever, headache, body pain, nasal obstruction, nasal discharge, hypoolfaction, cough, thin and white sputum, thin and white tongue fur, floating and tight pulse and the like, which are caused by wind-cold epidemic toxin and the lung syndrome after the infection of the novel coronavirus, is still lacking at present. In clinical treatment, even if the patients are heat-relieved, symptoms such as nasal obstruction, nasal discharge, cough, expectoration and the like are often left, and the existing treatment scheme can not thoroughly solve the suffering of the patients.
Therefore, a need still exists for a novel Chinese medicinal composition for treating coronavirus infection with pertinence to the syndrome of wind-cold epidemic toxin attacking lung.
Disclosure of Invention
The first object of the present invention is to provide a traditional Chinese medicine composition for dispelling wind-cold, so as to solve at least one of the above technical problems.
The second object of the present invention is to provide a preparation method of the traditional Chinese medicine composition, so as to solve at least one of the above technical problems.
The third object of the present invention is to provide an application of the traditional Chinese medicine composition, so as to solve at least one of the above technical problems.
According to one aspect of the invention, there is provided a traditional Chinese medicine composition for dispelling wind-cold, comprising the following main active ingredients in parts by mass: 5-10 parts of ephedra herb, 10-15 parts of divaricate saposhnikovia root, 15-20 parts of notopterygium root, 15-20 parts of perilla leaf, 5-10 parts of dahurian angelica root, 5-10 parts of bitter apricot seed, 10-15 parts of platycodon root, 15-20 parts of aster and 15-20 parts of peucedanum root.
In the formula of the invention, ephedra is bitter and pungent in nature, can reach the muscle surface, walk the channels and collaterals, can greatly dispel wind evil and dispel cold toxin (the body resistance of materia medica); wind-proof and exterior-relieving are long in treating wind, wind-proof and wind-treating general purpose, ascending and dispersing in the theory of "Ben Cao Jing Shu", and both of them disperse wind-cold to relieve exterior-heat, so that pathogenic wind-cold is relieved from sweat, which is a monarch drug. Notopterygium root, rhizoma Et radix Notopterygii, as a bitter flavor Wen Jineng, has the effects of dispelling pathogenic wind and relieving pain, and is effective in treating pain of all joints of the body and the body, and expelling pathogenic wind and evil from the muscles and the superficies (the essence of the product is collected); perilla leaf is a "smart medicine" for treating wind-cold type common cold, and has effects of opening fur, relieving lung qi and dredging striae; the upper part of the medicine is used for relieving stuffy nose and clearing head and eyes (Ben Cao Zheng Yi), and the two are ministerial medicines and monarch medicines, so that the medicine can strengthen the effects of dispelling wind and cold and relieving exterior syndrome, and also can remove head and body pain and nasal obstruction and nasal discharge. The platycodon grandiflorum can ascend and descend, and the "platycodon grandiflorum can carry both medicines upwards and qi downwards according to books", mainly ascend, can ventilate lung qi, ascend, clear and descend turbidity and clear sources and promote diuresis; almond is pungent, bitter and bitter in flavor and falls, and "the recipe is specially used for lowering qi, qi lowering then phlegm eliminating and cough stopping" is pointed out in "Ben Cao Di Ji Shen", and the two are mutually combined, and the recipe is lifted and regulated. The front Hu Guxin is slightly cold, which not only assists the monarch drug to disperse the exterior lightly, but also helps the almond to reduce the qi and phlegm; aster root, radix Asteris is pungent and bitter in taste and warm in nature and has the effects of moistening lung and descending qi, resolving phlegm and relieving cough, and both are mutually compatible, warm but not dry, cool but not moist. Radix Platycodi, semen Armeniacae amarum, radix Peucedani, and radix Asteris are all adjuvant drugs and have effects of eliminating phlegm and relieving cough. Radix Angelicae Dahuricae is a guiding drug, and in Ben Cao Zheng Yi, dahurian angelica is pungent and warm in nature, aromatic and dry and drastic, wind-dispelling and cold-dispelling, ascending head and eyes and clearing orifices, also can dry dampness and raise yang, reach skin externally, extract qi internally, not only strengthen the effect of all drugs on exterior, but also unblock orifices and relieve pain. The medicines are combined together to play the roles of dispelling wind-cold, eliminating phlegm and relieving cough.
The traditional Chinese medicine composition provided by the invention can effectively relieve symptoms such as aversion to cold, fever, headache, body pain, nasal obstruction, clear nasal discharge, hyposmia, cough, thin white phlegm, thin white tongue fur, floating pulse and the like which are shown by a novel coronavirus infected patient with wind-cold epidemic toxin attacking lung syndrome, especially has obvious curative effects on symptoms such as fever, nasal obstruction, nasal discharge, cough, chill or chills, abnormal taste and the like, and can be used for preparing medicaments for treating novel coronavirus infection, especially medicaments for preparing novel coronavirus infected patient with wind-cold epidemic toxin attacking lung syndrome.
In some embodiments, the traditional Chinese medicine composition for dispelling wind-cold comprises the following main active ingredients in parts by mass: 5 parts of ephedra herb, 10 parts of divaricate saposhnikovia root, 15 parts of notopterygium root, 15 parts of perilla leaf, 10 parts of dahurian angelica root, 10 parts of bitter apricot seed, 10 parts of platycodon root, 15 parts of aster and 15 parts of radix peucedani.
The traditional Chinese medicine composition for dispelling wind-cold is mainly used for treating symptoms such as aversion to cold, fever, headache, body pain, nasal obstruction, clear nasal discharge, hyposmia, cough, thin white sputum, thin white tongue fur, floating pulse and the like after novel coronavirus infection, in the practical application process, the dosage and the type of raw medicinal materials can be modified according to the specific symptoms of patients and the light and heavy degree of the symptoms, and if the pharyngalgia is obvious, 10-20 parts of blackberry lily and 5-15 parts of burdock can be added; if cough is obvious, 5-15 parts of loquat leaf can be added.
The sources of the raw materials of the method are as follows:
herba Ephedrae: is the grass stem of herba Ephedrae Ephedra sinica Stapf, herba Ephedrae Ephedra intermedia Schrenk et C.A.Mey or herba Equiseti hiemalis Ephedra equisetina Bge of Ephedraceae genus herba Ephedrae. Pungent and slightly bitter in taste and warm in nature; enter lung and bladder meridians.
Wind prevention: is root of Ledebouriella plant of Ledebouriella of Umbelliferae Saposhnikovia divaricata (Turcz.) Schischk. Pungent and sweet in taste and slightly warm in nature; it enters the urinary bladder, lung, spleen and liver meridians.
Notopterygium root: is root and stem of Notopterygium incisum Notopterygium incisum Ting ex H.T.Chang or Notopterygium forbesii Notopterygium forbesii Boiss. Pungent and bitter in taste and warm in nature; enter bladder and kidney meridians.
Perilla leaf: leaves or tender branch leaves of the plant Perilla Perilla frutescens (L.) Britt.var arguta (benth.) hand (-Mazz.) and Perilla frutescens (L.) Britt.var.purplaservice (Hayata) H.W.Li [ P.frexecens (L.) Britt.var.acuta (thunder.) Kudo ] of the genus Perilla of the family Labiatae. Pungent taste and warm nature; enter lung, spleen and stomach meridians.
Radix angelicae: is root of Angelica dahurica Angelica dahurica (Fisch. Ex Hoffm) and Angelica dahurica Angelica dahurica (Fisch ex Hoffm.) belonging to Angelica genus of Umbelliferae. Pungent taste and warm nature; enter stomach, large intestine and lung meridian.
Bitter apricot kernel: is the mature fruit of the plant Prunus armeniaca L.var. Ansu Maxim. Siberian apricot P.sibirica L.northeast apricot P.mandshurica (Maxim) Koehne or apricot P.armeniaca L. Bitter taste and slightly warm nature; enter lung and large intestine meridians.
Radix Platycodi: is dry root of radix Platycodi Platycodon grandiflorus (Jacq.) A.DC. Bitter and pungent taste and neutral nature; enter lung meridian.
Radix Asteris: is root and rhizome of Aster asteris L.F. Bitter, pungent and sweet in taste and slightly warm in nature; enter lung meridian.
Radix peucedani: is root of Peucedanum praeruptorum or Peucedanum praeruptorum maxin of Peucedanum of Umbelliferae Peucedanum praeruptorum Dunn. Bitter and pungent taste and slightly cold nature; enter lung meridian.
Blackberry lily: is dried rhizome of Belamcanda chinensis Belamcanda chinensis (L.) DC. Bitter taste and cold nature; enter lung meridian.
Fructus Arctii: is dried mature fruit of Arctium lappa L. Pungent and bitter in flavor and cold in nature; enter lung and stomach meridians.
Loquat leaves: is leaf of Eriobotrya japonica Eriobotrya japonica (thunder.) Lindl. Bitter taste and slightly cold nature; enter lung and stomach meridians.
In some embodiments, the dosage form of the traditional Chinese medicine composition can be decoction, tablets, capsules, granules, oral liquid or powder.
In some embodiments, pharmaceutically acceptable excipients, such as sustained release agents, excipients, fillers, binders, wetting agents, disintegrants, absorption enhancers, adsorption carriers, surfactants, lubricants, and the like, are also included.
When the Chinese medicinal composition is decoction, the preparation method can comprise the following steps:
mixing the raw materials according to a proportion, adding 8-12 times of water by weight for soaking for 20-40 minutes, then decocting for 1-2 hours, filtering, repeatedly decocting filter residues for 1-2 times, and combining the filtrates to obtain the traditional Chinese medicine. The filtrate can be packaged after cooling, thereby being convenient to carry and distribute.
When in powder form, the preparation method can comprise the following steps:
respectively pulverizing or shredding the raw materials, sieving the pulverized or shredded raw materials with 10 mesh and 50 mesh sieve, continuously pulverizing or shredding coarse particles which cannot pass through the 10 mesh sieve, taking powder between the 10 mesh sieve and the 50 mesh sieve, uniformly mixing the raw material powder according to a proportion, filling into a sealing bag, and sealing.
In the case of other dosage forms such as tablets, capsules, granules and the like, the preparation method can comprise the following steps:
mixing the raw materials according to a proportion to prepare extract (each 1g of extract is equivalent to 2-5g of the raw materials), adding auxiliary materials, and preparing corresponding dosage forms according to a traditional Chinese medicine conventional preparation process.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The raw materials and reagents used in the present invention are commercially available unless otherwise specified.
Example 1
The traditional Chinese medicine decoction for dispelling wind-cold of the embodiment is prepared from the following raw materials: 5g of ephedra herb, 10g of divaricate saposhnikovia root, 15g of notopterygium root, 15g of perilla leaf, 10g of dahurian angelica root, 10g of apricot, 10g of platycodon root, 15g of aster and 15g of radix peucedani.
The preparation method comprises the following steps:
mixing the raw materials according to a certain proportion, soaking in 10 times of water for 30 min, heating to boil, keeping micro boiling for 1 hr, and filtering to obtain a first decoction and residue; adding water 8 times of the total weight of the raw materials into the residue obtained after the first decoction, heating to boil, keeping micro-boiling for 1 hour, and separating to obtain a second decoction and residue; and combining the first decoction and the second decoction.
In order to verify the treatment effect of the traditional Chinese medicine composition, the invention develops clinical researches by taking the wind-cold dispelling prescription decoction prepared in the embodiment 1 of the invention as a test medicine, and the research process and the result are as follows:
1. correlation standard
1.1 diagnostic criteria
1.1.1 Western medicine disease diagnosis
Referring to the novel diagnosis and treatment scheme of coronavirus infection (tenth edition of trial), epidemiological history and clinical manifestation are shown, and etiology evidence (positive detection of novel coronavirus or positive detection of antigen) is met.
Disease typing refers to the diagnosis and treatment scheme (tenth edition of trial) of novel coronavirus infection, and is classified into light, common, heavy and dangerous.
1.1.2 criteria for diagnosis of waiting for Chinese medical Condition
Syndrome of exogenous wind-cold: aversion to cold, fever, headache, body pain, nasal obstruction, clear nasal discharge, hyposmia, cough, thin white sputum and thin white tongue fur. The pulse is superficial and tight.
1.2 inclusion criteria
(1) Detecting positive for the novel coronal nucleic acid or antigen;
(2) The model is based on the typing standard of the novel coronavirus infection diagnosis and treatment scheme (tenth edition of trial) and belongs to light people.
(3) Age 18-65 years (including boundary values);
(4) Signing the informed consent.
Exclusion criteria:
(1) Acute origins of severe basal diseases or chronic diseases, such as acute heart failure, are combined.
(2) Female subjects during pregnancy, lactation or lactation;
(3) The disease affecting the duration of symptoms such as bronchopneumonia, chronic lung abscess, chronic cough for more than 8 weeks, chronic pharyngolaryngitis and cough.
3. Case withdrawal and shedding
Case withdrawal and abscission refers to cases where patients are not willing to continue to participate in clinical trials during the course of the study after entering the group or are unable to complete the full course of treatment as prescribed.
Treatment of withdrawn and exfoliated cases: the researcher should contact the subject by home visit, telephone, letter and the like, record the last treatment time and complete the completed evaluation project. And knows the reason for its exit, as recorded in the case report form. The observation data of all the withdrawn and fallen cases are reserved.
2. Case origin: a new light case of coronavirus infection diagnosed at the febrile clinic in the middle of Guangdong province during the study period.
3. Intervention and grouping:
all patients taking the wind-cold dispelling prescription are taken 200mL of the wind-cold dispelling prescription decoction prepared in the embodiment 1, 1 dose per day, 2 times a day and 100mL of the wind-cold dispelling prescription are taken each time, and the median treatment course is 5 days.
All patients are treated according to the novel pneumonia diagnosis and treatment scheme (trial ninth edition) of coronavirus infection after entering the group, so that the basic treatment of the patients is ensured, but the antiviral treatment is not carried out.
4. Statistical methods:
the measurement data is subjected to normal test, and accords with normal average number +/-standard deviation description, normal distribution using median and quarter bit description, curative effect is successively compared, normal distribution data is subjected to paired t test, and non-normal distribution data is subjected to non-parameter test. The counting data is checked by using a chi-square.
5. Test results
1. Baseline analysis
Baseline data for the patients are shown in table 1:
table 1 baseline profile for patients
As shown in table 1, the two groups of sex distribution are balanced, and compared with the control group which does not take the wind-cold dispelling decoction, the patients in the wind-cold dispelling decoction are older; the prescription for dispelling wind-cold is obviously longer than the control group in the time from onset to follow-up, and the control group uses more combined medicines, in particular to cough relieving and phlegm reducing medicines.
2. The symptoms of the patient at the time of onset are shown in Table 2
TABLE 2 patient's onset symptoms form
| Symptoms (n,%) | Control group (n=47) | Square group for dispelling wind-cold (n=78) |
| Heating up | 38(80.8) | 66(84.6) |
| Cough with cough | 44(93.6) | 61(78.2) |
| Nasal obstruction or runny nose | 33(70.2) | 42(53.8) |
| Sore throat | 36(76.5) | 40(51.2) |
| Muscle pain | 29(61.7) | 26(33.3) |
| Headache pain | 24(51.0) | 22(28.2) |
| Tired | 36(76.5) | 20(25.6) |
| Aversion to cold or chills | 27(57.4) | 22(28.2) |
| Dysgeusia | 14(29.7) | 18(23.0) |
| Abnormal smell sense | 11(23.4) | 8(10.2) |
| Shortness of breath or dyspnea | 23(48.9) | 8(10.2) |
| Diarrhea (diarrhea) | 13(27.6) | 5(6.41) |
| Nausea of | 13(27.6) | 4(5.12) |
| Vomiting of vomiting | 5(10.6) | 5(6.41) |
As shown in table 2, the top four symptoms of the recipe for dispelling wind-cold were fever, cough, nasal obstruction/running nose and sore throat; the highest symptom of the formula for dispelling wind-cold is fever, the proportion is 84.6%, and the symptom advantage is taken of cough (78.2%) with the second symptom.
3. Symptom disappearance condition table after patient uses medicine
Table 3 patient symptom disappearance evaluation scale
As shown in Table 3, compared with the control group, the wind-cold dispelling prescription has better effects on fever, nasal obstruction/nasal discharge, cough, chill/chills, and abnormal taste, and the difference has statistical significance.
4. Symptom disappearance schedule after administration of the drug to the patient
TABLE 4 evaluation of time to disappearance of symptoms in patients
| Symptom vanishing time (day, IQR) | Control group (n=47) | Square group for dispelling wind-cold (n=78) | P value |
| Heating up | 4(3-5) | 2(2-3.25) | 0.017 |
| Nasal obstruction or runny nose | 5.5(3.25-8.5) | 5(3-7) | 0.622 |
| Sore throat | 4.5(3.75-7.75) | 4(2-6) | 0.291 |
| Shortness of breath or dyspnea | 6(6-6) | 1(1-1) | 0.317 |
| Cough with cough | 4(2.5-10.5) | 7(6-10) | 0.383 |
| Tired | 7.5(3.75-10.5) | 5(2.25-9.25) | 0.468 |
| Muscle pain | 5(2-6.5) | 4(2-6.25) | 0.682 |
| Headache pain | 4.5(2.75-5.25) | 2(2-4) | 0.134 |
| Aversion to cold or chills | 5(1-6) | 2(2-4.5) | 0.66 |
| Nausea of | - | 2(1-3) | - |
| Vomiting of vomiting | 3(3-3) | 3(2-4) | >0.999 |
| Diarrhea (diarrhea) | 3(2.25-7.5) | 4(2-6) | 0.812 |
| Abnormal smell sense | - | 3.5(1.25-8.75) | - |
| Dysgeusia | - | 5(4-8) | - |
As shown in table 4, the formula for dispelling wind-cold significantly shortens the fever time of the patients relative to the control group.
5. Residual symptom table after treatment of patient
Table 5 table of residual symptoms after patient treatment
| Symptoms (n,%) | Control group (n=47) | Square group for dispelling wind-cold (n=78) |
| Cough with cough | 37(78.7) | 38(48.7) |
| Nasal obstruction or runny nose | 23(48.9) | 13(16.6) |
| Sore throat | 11(23.4) | 10(12.8) |
| Tired | 23(48.9) | 16(20.5) |
| Dysgeusia | 16(34.0) | 4(5.1) |
| Headache pain | 7(14.8) | 4(5.1) |
| Abnormal smell sense | 13(27.6) | 3(3.8) |
| Shortness of breath or dyspnea | 15(31.9) | 5(6.4) |
| Muscle pain | 11(23.4) | 1(1.3) |
| Diarrhea (diarrhea) | 3(6.4) | 3(3.8) |
| Heating up | 6(12.7) | 1(1.3) |
| Aversion to cold or chills | 15(31.9) | 4(5.1) |
| Nausea of | 5(10.6) | 0(0) |
| Vomiting of vomiting | 0(0) | 1(1.3) |
As shown in Table 5, the main residual symptoms after treatment of the wind-cold dispelling prescription are cough, the control group accounts for 78.7%, the wind-cold dispelling prescription accounts for 48.7%, and the symptoms except nasal obstruction/nasal discharge, sore throat and tiredness after treatment of each group are less than 10%.
6. Conclusion:
(1) After 5 days of treatment by taking the wind-cold dispelling prescription, the symptoms of patients are obviously improved, and the difference has statistical significance.
(2) The formula for dispelling wind-cold can obviously relieve cough and other symptoms of patients, and obviously shorten the disappearance time of various symptoms.
According to the traditional Chinese medicine composition for dispelling wind-cold, in the actual application process, the dosage and the types of the raw medicinal materials can be subjected to temporary modification according to the specific symptoms of patients and the degree of the symptoms, such as: on the basis of the example 1, 15g of blackberry lily and 10g of burdock can be added if the pharyngalgia is obvious; if cough is obvious, 10g of loquat leaf can be added.
What has been described above is merely some embodiments of the present invention. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit of the invention.
Claims (9)
1. The traditional Chinese medicine composition for dispelling wind-cold is characterized by comprising the following main active components in parts by mass: 5-10 parts of ephedra herb, 10-15 parts of divaricate saposhnikovia root, 15-20 parts of notopterygium root, 15-20 parts of perilla leaf, 5-10 parts of dahurian angelica root, 5-10 parts of bitter apricot seed, 10-15 parts of platycodon root, 15-20 parts of aster and 15-20 parts of peucedanum root.
2. The wind-cold dispelling traditional Chinese medicine composition according to claim 1, wherein the main active ingredients of the composition comprise, in parts by mass: 5 parts of ephedra herb, 10 parts of divaricate saposhnikovia root, 15 parts of notopterygium root, 15 parts of perilla leaf, 10 parts of dahurian angelica root, 10 parts of bitter apricot seed, 10 parts of platycodon root, 15 parts of aster and 15 parts of radix peucedani.
3. The wind-cold dispelling Chinese medicinal composition according to claim 1 or 2, wherein the main active ingredients further comprise one or more selected from the group consisting of 10-20 parts of blackberry lily, 5-15 parts of burdock and 5-15 parts of loquat leaf, by mass.
4. The wind-cold dispelling Chinese medicinal composition according to claim 3, wherein the Chinese medicinal composition is in the form of decoction, tablet, capsule, granule, oral liquid or powder.
5. The wind-cold dispelling Chinese medicinal composition according to claim 4, further comprising pharmaceutically acceptable excipients.
6. The wind-cold dispelling Chinese medicinal composition according to claim 5, wherein the pharmaceutically acceptable adjuvant is at least one selected from a sustained release agent, an excipient, a filler, an adhesive, a wetting agent, a disintegrating agent, an absorption enhancer, an adsorption carrier, a surfactant, and a lubricant.
7. The method for preparing the traditional Chinese medicine composition for dispelling wind-cold according to claim 4, wherein when the traditional Chinese medicine composition is a decoction, the method for preparing the traditional Chinese medicine composition comprises the following steps:
mixing the raw materials according to a proportion, adding 8-12 times of water by weight for soaking for 20-40 minutes, then decocting for 1-2 hours, filtering, repeatedly decocting filter residues for 1-2 times, and combining the filtrates to obtain the traditional Chinese medicine.
8. Use of a traditional Chinese medicine composition for dispelling wind-cold according to any one of claims 1-6 for preparing a medicament for treating novel coronavirus infection.
9. The use according to claim 8, wherein the novel coronavirus infection is a wind-cold epidemic lung syndrome type novel coronavirus infection.
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| CN103054973A (en) * | 2012-12-23 | 2013-04-24 | 徐化利 | Traditional Chinese medicine prescription for treating cold |
| CN103877184A (en) * | 2012-12-21 | 2014-06-25 | 于骞 | Medicine for treating children cough and asthma |
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| CN103054973A (en) * | 2012-12-23 | 2013-04-24 | 徐化利 | Traditional Chinese medicine prescription for treating cold |
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| Title |
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| 倪萍；等: "十神汤治疗早期新型冠状病毒肺炎探析", 《河南中医》, vol. 40, no. 6, pages 824 - 826 * |
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