CN115486487A - Tea drink composition based on medicinal and edible traditional Chinese medicinal materials and application thereof - Google Patents

Tea drink composition based on medicinal and edible traditional Chinese medicinal materials and application thereof Download PDF

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Publication number
CN115486487A
CN115486487A CN202210684964.7A CN202210684964A CN115486487A CN 115486487 A CN115486487 A CN 115486487A CN 202210684964 A CN202210684964 A CN 202210684964A CN 115486487 A CN115486487 A CN 115486487A
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traditional chinese
medicinal
drink composition
tea
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张均倡
何杜朋
羊燕群
肖烈辉
杨西晓
郑泽娜
王子威
汪东涛
黄敏娜
何怡芊
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Shenzhen Hospital of Southern Medical University
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Shenzhen Hospital of Southern Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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Abstract

The invention belongs to the technical field of functional foods, and particularly relates to a tea drink composition based on medicinal and edible traditional Chinese medicinal materials and application thereof. The tea drink composition disclosed by the invention comprises the following main active ingredients in parts by mass: 10-20 parts of astragalus membranaceus, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of perilla leaf, 5-15 parts of mint, 5-15 parts of platycodon grandiflorum, 5-15 parts of houttuynia cordata, 5-15 parts of lophatherum gracile and 5-15 parts of reed rhizome. The invention also provides application of the tea drink composition. The tea beverage composition provided by the invention takes 'strengthening body resistance and eliminating evil' as a method, completely adopts medicinal and edible traditional Chinese medicinal materials or traditional Chinese medicinal materials for health care products, has the effects of tonifying qi, strengthening exterior, clearing heat and removing toxicity, and can be beneficial to preventing epidemic and/or non-epidemic respiratory infectious diseases (such as novel coronary viral pneumonia and influenza A). The tea drink composition has obvious advantages on applicable people as a health food, can be widely applied to susceptible people not infected with epidemic diseases in the epidemic disease prevention stage, and has the advantages of good safety, reasonable formula, pertinence and strong practicability.

Description

Tea drink composition based on medicinal and edible traditional Chinese medicinal materials and application thereof
Technical Field
The invention belongs to the technical field of functional foods, and particularly relates to a tea drink composition based on medicinal and edible traditional Chinese medicinal materials and application thereof.
Background
In recent years, a wide range of viral infectious respiratory diseases, particularly novel coronavirus pneumonia (hereinafter referred to as new coronavirus pneumonia) occur worldwide, the novel coronavirus has many variations, strong infectivity and quick transmission, and the public health is seriously threatened, so that the social burden is greatly increased. Because the new coronary pneumonia does not have a specific medicine at present, prevention and prevention of epidemic spread are key points of epidemic prevention work. At present, the prevention measure of the western medicine aiming at the viral pneumonia such as the new coronary pneumonia is the injection vaccine. However, the novel coronavirus has high mutation speed, the novel variant strain can become a main global epidemic strain from an early alpha and delta strain to a newly-appeared Oncken strain within about 3-6 months, a preventive specific immune vaccine always tracks the development of the variant virus, and the novel coronavirus is passive and has unsatisfactory effect, so that the epidemic situation is difficult to prevent from spreading fundamentally.
The traditional Chinese medicine considers that: respiratory viral infectious diseases such as new coronary pneumonia, influenza and the like belong to the category of epidemic diseases and pestilence of the traditional Chinese medicine. The idea of epidemic disease prevention and treatment from Huangdi's Canon of medicine includes the disease prevention concept of ' healthy qi exists in the interior and the pathogens cannot be dried ' and ' the disease is not treated but is not treated yet ', then the theory of typhoid fever and the theory of epidemic disease gradually form the pestilence system of infectious disease prevention and treatment, and the concept of epidemic disease prevention is deep into civilian mind and traditional Chinese medicine theory.
In order to fully exert the function of traditional Chinese medicines in prevention and control of epidemic diseases such as new coronary pneumonia, a traditional Chinese medicine prevention and treatment scheme for new coronary pneumonia is published in a plurality of provinces and cities in China, however, the traditional Chinese medicine prevention and treatment scheme for susceptible people not infected with new coronary pneumonia viruses disclosed in the prior new coronary pneumonia all contains one or more traditional Chinese medicines which do not belong to medicinal materials in a list of articles which are foods and medicines (or a list of substances which are foods and traditional Chinese medicines according to the tradition (food and medicine substance), or a list of articles which can be used for health foods (or a list of health food raw materials), and the traditional Chinese medicine prevention prescription belongs to a prescription (namely a traditional Chinese medicine prescription containing non-edible traditional Chinese medicines except the two lists). As a measure in the prevention stage, the popularization of adopting a medicinal prescription as a prevention means aiming at susceptible people (including normal people in a non-disease state or people suffering from other diseases) not infected with the current infectious diseases does not meet the safety or medicine supervision requirements of medical ethics, and has certain potential safety hazard, so that a plurality of traditional Chinese medicine prevention prescriptions are not suitable for being taken by the susceptible people at present. In addition, the drug prescription needs to be strictly subjected to drug registration management before the product is marketed, the marketing period is long, and quick emergency response cannot be performed when the related epidemic situation comes, so that the range and the effect of epidemic situation prevention and control can be influenced to a certain extent.
Because the prevention scheme of the new coronary pneumonia is usually formulated together with the prevention and treatment scheme, the formulators mostly adopt clinical medical experts which generally think that the related traditional Chinese medicinal materials have small side effect and are commonly used in clinic, and therefore, the change of the drug administration objects in the prevention stage is not concerned. In fact, the susceptible population is significantly different from the clinically diagnosed patient, and the related regulatory requirements and measures of the drugs used by the susceptible population are completely different. Therefore, there is a need to develop a non-medicinal prescription for effectively preventing the occurrence of epidemic diseases such as new coronary pneumonia, etc., so as to satisfy the epidemic prevention requirements of a large number of susceptible people (including normal people in non-disease state or people suffering from other diseases) not infected with the current infectious diseases.
Disclosure of Invention
The invention provides a tea composition based on medicinal and edible traditional Chinese medicinal materials. The invention also provides application of the tea beverage composition based on medicinal and edible traditional Chinese medicinal materials.
According to the first object of the invention, the tea drink composition based on medicinal and edible traditional Chinese medicinal materials is provided, and the main active ingredients comprise the following components in parts by mass: 10-20 parts of astragalus membranaceus, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of perilla leaf, 5-15 parts of mint, 5-15 parts of platycodon grandiflorum, 5-15 parts of houttuynia cordata, 5-15 parts of lophatherum gracile and 5-15 parts of reed rhizome.
The sources of the raw material medicines of the invention are as follows:
astragalus root: dried root of Astragalus membranaceus (Fisch.) bge of Leguminosae family such as Astragalus membranaceus (bge.) Astragalus membranaceus (var. Mongholicus (bge.) Hsiao or Astragalus membranaceus (Fisch.) bge.
White atractylodes rhizome: dried rhizome of Atractylodes macrocephala Koidz of Compositae.
Perilla leaf: dried leaves (or with shoots) of Perilla frutescens (L.) Britt, a Labiatae plant.
Mint: dried aerial parts of Mentha haplocalyx Briq. Of Mentha of Labiatae.
And (3) platycodon root: dried root of Platycodon grandiflorum (jacq.) a.dc.
Houttuynia cordata: dried aerial parts of Houttuynia cordata Thunb of Saururaceae.
Herba lophatheri: dried stems and leaves of Lophatherum gracile Brongn of Gramineae.
Reed rhizome: fresh or dried rhizome of Phragmitis communis Trin, poaceae.
In some embodiments, the tea composition may be in a solid dosage form or a liquid dosage form, wherein the solid dosage form may be a granule, a powder, a tablet, an effervescent tablet, a capsule, a pill, a drop pill or a tea bag, and the liquid dosage form may be a decoction, a mixture, an oral liquid or an ointment.
In some embodiments, the tea drink composition further comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials comprise one or more of a filler, a binder, a disintegrating agent and a lubricant, and one or more of a flavoring agent, a coloring agent, a preservative and a medicinal surfactant.
The tea composition can be prepared into corresponding dosage forms according to the preparation method of the traditional Chinese medicine.
In the preparation process, according to actual needs, one part of medicinal materials in the raw material formula of the tea composition can be directly crushed, the other part of medicinal materials are prepared into extract powder, then the crushed medicinal materials and the extract powder are uniformly mixed to form intermediate raw materials, and a final preparation form is formed according to the requirements of different solid or liquid preparation forms, for example, the intermediate raw materials are filled into a tea bag according to the requirements of the tea bag to obtain the tea bag; or crushing all the medicinal materials in the raw material formula of the tea composition or preparing all the medicinal materials into extract powder, then uniformly mixing the crushed medicinal materials or the extract powder to form intermediate raw materials, and then forming a final preparation according to the requirements of different solid or liquid preparation formulations, for example, filling the intermediate raw materials into a tea bag according to the requirements of the tea bag to obtain the tea bag.
In addition, the single medicine formula granules purchased from the market can be mixed according to the proportion to obtain the formula granule electuary; or taking the formula granules as intermediate raw materials, and forming final dosage forms according to the requirements of different solid or liquid dosage forms, for example, filling the intermediate raw materials into tea bags according to the requirements of the tea bags to obtain the tea bags.
It should be noted that when the tea composition of the present invention is decocted, the mint needs to be treated according to the principle of "back-to-back", i.e. the raw materials except the mint are decocted first, and the mint is added about five minutes before the decoction is completed, so as to prevent the active substances in the mint from being excessively volatilized.
The tea composition of the invention can be prepared by boiling ginger and fistular onion stalk in water or taken together in cold seasons or under cold conditions for a long time.
According to the second purpose of the invention, the application of the tea beverage composition based on medicinal and edible traditional Chinese medicinal materials in preparing health-care food for preventing respiratory tract exogenous diseases is provided.
Exogenous disease refers to the disease of the body caused by invasion of exogenous pathogenic factors. The respiratory tract exogenous disease is particularly the respiratory tract exogenous disease called as 'wind pathogen is suffered and first invades lung' in traditional Chinese medicine, and belongs to the category of 'epidemic disease' and 'pestilence' in traditional Chinese medicine. The Chinese medicine considers that the basic characteristics of wind evil are as follows: the Chinese medicinal composition is easy to spread and popular, has uncertainty of multiple change ends and no pore and no input; and its manifestations are also varied after feeling wind evil. Wind pathogen belongs to yang pathogen, and according to the principle of competing with qi, it firstly invades the upper jiao, and then it invades the heart and lung, and the lung is the delicate organ, and it is most vulnerable to pathogenic factors, so the first manifestation of lung qi damage occurs. The epidemic and/or non-epidemic respiratory tract (upper respiratory tract and lower respiratory tract) infectious diseases in modern medicine belong to the category of respiratory tract external infection diseases, wherein the respiratory tract infectious diseases comprise viral cold and viral pneumonia, the viral cold comprises influenza A, and the viral pneumonia comprises novel coronary viral pneumonia.
The tea drink composition is used as a health food, is suitable for preventing respiratory tract exogenous diseases of wide susceptible people, and is mainly characterized in that:
the tea beverage composition provided by the invention is prepared according to the following three principles: (1) the composition is completely composed of medicinal and edible traditional Chinese medicinal materials, (2) strengthening body resistance and (3) eliminating evil, so that the tea beverage composition has good edible safety, outstanding compatibility pertinence and feasible emergency practicability, and specifically:
(1) Good edible safety
The raw medicinal materials used in the invention belong to traditional Chinese medicinal materials in a list of articles which are both food and medicine (perilla leaf, mint, platycodon root, houttuynia cordata, lophatherum gracile and reed rhizome) and a list of articles which can be used for health food (astragalus mongholicus and bighead atractylodes rhizome), and the safety and effectiveness of the traditional Chinese medicinal materials in the two lists (or catalogues) are approved by the national food and drug administration, so that the traditional Chinese medicinal materials are allowed to be recorded and managed as health food without additional approval. Therefore, the raw materials used in the invention have the characteristics of homology of medicine and food and safe medication, the edible safety is fully guaranteed, the health food is convenient to be used by people without epidemic diseases in a prevention stage, the health food has obvious advantages in applicable people, and the prevention scheme can meet the application requirements in a large range.
(2) Outstanding compatibility pertinence
The invention considers that the prevention of epidemic diseases needs to play a role in strengthening body resistance and eliminating evil. The healthy qi is the adaptive capacity, defense capacity and health recovery capacity of the organism to the external environment, and is basically consistent with the immune function; pathogenic qi refers to pestilence (various toxins, pathogenic microorganisms, etc.). The dominant status of healthy qi and the external condition of pathogenic qi determine the development of disease.
Strengthening body resistance (improving immunity or resistance): the Qing Dynasty doctor who inherits the book of 'Ready to read' for the Jade Screen powder has an exquisitely reading: the middle warmer is established first for all cases with exterior deficiency failing to defend the body, so the spleen-tonifying middle warmer is the monarch drug for Atractylodis rhizoma, while the spleen-tonifying middle warmer is the dominant drug for the four zang organs, and the exterior is self-consolidating without pathogenic dryness; moreover, the astragalus root can strengthen the exterior and strengthen the defense, so that the people who walk well and get the wind-proof are afraid of each other, and the functions of the people are out of the middle, the astragalus root can not worry about the strengthening of the pathogens, and the wind-proof can not worry about the dispersing of the exterior, so that the dispersing can tonify the interior and dredge the interior.
However, the ledebouriella seseloides contained in the jade screen powder does not belong to the traditional Chinese medicinal materials in the article list of food and medicine or the article list of health food, and has certain limitations in the aspects of edible safety and medication management, so that the jade screen powder or other traditional Chinese medicine compositions containing ledebouriella seseloides cannot be directly and completely popularized and used in susceptible people as a traditional Chinese medicine prevention prescription.
According to the clinical experience advocated by the inventor and named as Guangdong famous traditional Chinese medicine, the invention takes Yupingfengsan as a main prescription, adopts mint and perilla leaf to replace divaricate saposhnikovia root, has the effects of dispelling stasis and relieving stuffiness, disperses the lung and exterior syndrome, and promotes qi circulation to reduce phlegm, has the effects of opening and ventilating lung qi, facilitating movement, specially attacking exterior syndrome and dispelling evil (exogenous evil) and successfully replacing the divaricate saposhnikovia root, and is particularly suitable for the exogenous disease of the respiratory tract caused by wind evil.
Eliminating pathogenic factors: the invention aims at the characteristic that the upper-suffered evil is mostly warm evil or enters the interior to dissipate heat and the theory of traditional Chinese medicine warm disease, adopts heat-clearing and detoxifying medicine which is good at clearing lung heat and relieving sore throat, clearing heat and promoting fluid and diuresis and is suitable for warm disease treatment of traditional Chinese medicine according to the clinical experience of the inventor: the platycodon root, the heartleaf houttuynia herb, the lophatherum gracile and the reed rhizome are used together, and the monarch drug of the main formula is used together to play the aim of eliminating pathogenic factors.
Therefore, the invention takes 'strengthening body resistance and eliminating evil' as a principle, eliminates evil on the basis of strengthening body resistance, improves human immunity, simultaneously eliminates pestilence and toxicity evil, and accords with the compatibility principle of disease prevention and treatment in traditional Chinese medicine.
The whole formula of the tea beverage composition has the effects of tonifying qi, strengthening the exterior, clearing heat and removing toxicity, strengthening the body resistance and eliminating pathogenic factors synchronously, and has the maximum prevention effect on viral pneumonia such as novel coronavirus and viral cold such as influenza A (the novel coronavirus pneumonia which is abused in recent years still belongs to the category of Chinese medical epidemic diseases or epidemic diseases).
(3) Feasible emergency practicability
The raw medicinal materials used in the tea beverage composition belong to traditional Chinese medicinal materials in a list of articles which are food and medicine and a list of articles which can be used for health-care food, so that the safety and effectiveness of the traditional Chinese medicinal materials in the two lists are approved by the national food and drug administration, and the traditional Chinese medicinal materials can be put into production for record management according to the requirements of the food safety law and the requirements of health-care food (functional food), and do not need to be registered and managed. Compared with the existing traditional Chinese medicine prevention prescription for respiratory tract exogenous diseases, the tea drink composition can avoid registration supervision on health-care food or medicines in the aspect of preventing and controlling sudden large-scale epidemic caused by the respiratory tract exogenous diseases and related diseases, so that quick emergency response can be carried out, and feasible emergency practicability of the tea drink composition is fully embodied.
In conclusion, the tea drink composition provided by the invention is used as a health food, has good edible safety, outstanding compatibility pertinence and feasible emergency practicability, is suitable for susceptible people to prevent respiratory tract external infection, particularly can avoid registration supervision on health food or medicines when large-scale epidemic situations caused by related diseases occur suddenly, and can be put into production quickly and respond to epidemic situation prevention and control needs quickly. Therefore, the method has obvious benefits or remarkable progress compared with the existing novel traditional Chinese medicine preventive prescription or preventive scheme for the coronary pneumonia.
Detailed Description
The present invention will be described in further detail with reference to the following embodiments.
Example 1
The tea beverage composition formula granule based on medicinal and edible traditional Chinese medicinal materials is prepared from the following components: 15g of raw astragalus, 10g of bran-fried bighead atractylodes rhizome, 9g of mint, 12g of perilla leaf, 9g of platycodon root, 12g of reed rhizome, 15g of cordate houttuynia and 10g of lophatherum gracile.
The preparation method comprises the following steps: mixing the single medicine formula granules purchased from the market according to the proportion to obtain the formula granule electuary.
From 3 months and 18 days in 2022, the tea drink composition formula granule prepared in the embodiment 1 of the invention is distributed to 62 medical personnel taking part in the nucleic acid detection of the novel coronavirus or the work of fever outpatient service, and no adverse reaction and respiratory tract exogenous diseases (including viral cold (including influenza A) and viral pneumonia (including novel coronavirus)) are found to occur to the medical personnel taking the tea drink composition. The concrete conditions are as follows:
1. data of subjects
62 medical staff who did not suffer from respiratory tract exogenous diseases and have negative new coronavirus detection and participated in nucleic acid detection or in fever clinics in about 1 week, wherein 21 men and 41 women have the age of 23-54. The subjects did not take other antiviral or anti-cold drugs during the period of taking the tea beverage composition formula granule of the present invention.
2. Method of administration
The tea drink composition prepared in the embodiment 1 is prepared into granules, a proper amount of hot water is added, and the mixture is stirred and melted to be taken, wherein the tea drink composition is taken for 2 times in 1 day and 1 dose in 1 time for 7 days continuously. If the patient is in cold condition for a long time, it can be blended with rhizoma Zingiberis recens and Bulbus Allii Fistulosi decoction or administered together with the decoction.
3. Criteria for therapeutic effect
The method has the following advantages: the subjects did not suffer from respiratory tract external infection (including viral cold (including influenza) and viral pneumonia (including novel coronavirus pneumonia)) within 1 month after taking the medicine.
And (4) invalidation: the subject can be administered with respiratory tract external infection (including viral cold (including influenza) and viral pneumonia (including novel coronavirus pneumonia) 1 or more times within 1 month.
4. Results
All subjects have no respiratory tract exogenous diseases (including viral cold (including influenza) and viral pneumonia (including novel coronavirus pneumonia)) within 1 month after taking the tea beverage composition formula granule, the effective rate is 62 cases, and the effective rate is 100%.

Claims (7)

1. A tea drink composition based on medicinal and edible traditional Chinese medicinal materials is characterized by comprising the following main active ingredients in parts by mass: 10-20 parts of astragalus membranaceus, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of perilla leaf, 5-15 parts of mint, 5-15 parts of platycodon grandiflorum, 5-15 parts of houttuynia cordata, 5-15 parts of lophatherum gracile and 5-15 parts of reed rhizome.
2. The tea drink composition based on medicinal and edible traditional Chinese medicinal materials as claimed in claim 1, wherein the dosage form of the tea drink composition comprises a solid dosage form and a liquid dosage form, the solid dosage form comprises a formula granule, a powder, a tablet, an effervescent tablet, a capsule, a pill, a dropping pill or a tea bag, and the liquid dosage form comprises a decoction, a mixture, an oral liquid or an ointment.
3. The tea drink composition based on medicinal and edible traditional Chinese medicinal materials as claimed in claim 2, which is characterized by further comprising pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials are one or more of a filling agent, an adhesive, a disintegrating agent and a lubricant, and one or more of a flavoring agent, a coloring agent, a preservative and a medicinal surfactant.
4. Use of the medicinal and edible traditional Chinese medicinal material-based tea composition according to any one of claims 1-3 in preparation of health food for preventing respiratory tract exogenous diseases.
5. The use of claim 4, wherein the respiratory tract external infection comprises a modern-medicine epidemic and/or non-epidemic respiratory tract infectious disease.
6. The use of claim 5, wherein the respiratory infectious disease comprises viral influenza and viral pneumonia.
7. The use of claim 6, wherein the viral cold comprises influenza and the viral pneumonia comprises novel coronary viral pneumonia.
CN202210684964.7A 2022-06-16 2022-06-16 Tea drink composition based on medicinal and edible traditional Chinese medicinal materials and application thereof Pending CN115486487A (en)

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