CN116239695A - 特异性结合pv-1蛋白的抗体或其抗原结合片段hlpv-p11及其应用 - Google Patents
特异性结合pv-1蛋白的抗体或其抗原结合片段hlpv-p11及其应用 Download PDFInfo
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Abstract
Description
抗体 | 重链可变区 | 轻链可变区 | 备注 |
HLPV-P00 | SEQ ID NO:01 | SEQ ID NO:02 | 原始抗体 |
HLPV-P01 | SEQ ID NO:03 | SEQ ID NO:04 | 中间抗体 |
HLPV-P02 | SEQ ID NO:05 | SEQ ID NO:15 | |
HLPV-P03 | SEQ ID NO:06 | SEQ ID NO:16 | |
HLPV-P04 | SEQ ID NO:07 | SEQ ID NO:17 | |
HLPV-P05 | SEQ ID NO:08 | SEQ ID NO:18 | |
HLPV-P06 | SEQ ID NO:09 | SEQ ID NO:16 | |
HLPV-P07 | SEQ ID NO:10 | SEQ ID NO:19 | |
HLPV-P08 | SEQ ID NO:11 | SEQ ID NO:20 | |
HLPV-P09 | SEQ ID NO:11 | SEQ ID NO:21 | |
HLPV-P10 | SEQ ID NO:08 | SEQ ID NO:22 | |
HLPV-P11 | SEQ ID NO:11 | SEQ ID NO:23 | |
HLPV-P12 | SEQ ID NO:12 | SEQ ID NO:24 | |
HLPV-P13 | SEQ ID NO:13 | SEQ ID NO:25 | |
HLPV-P14 | SEQ ID NO:14 | SEQ ID NO:25 |
抗体 | 抗体类型 | 亲和力常数 | 倍数 | 备注 |
HLPV-P00 | IgG1-Fc | 3.002×10-8 | 1.00 | 原始抗体 |
HLPV-P01 | IgG1-Fc | 4.107×10-9 | 7.31 | 中间抗体 |
HLPV-P02 | IgG1-Fc | 2.477×10-9 | 6.29 | |
HLPV-P03 | IgG1-Fc | 2.239×10-9 | 13.41 | |
HLPV-P04 | IgG1-Fc | 2.141×10-9 | 14.02 | |
HLPV-P05 | IgG1-Fc | 1.163×10-9 | 25.81 | |
HLPV-P06 | IgG1-Fc | 3.353×10-9 | 8.95 | |
HLPV-P07 | IgG1-Fc | 2.636×10-9 | 11.39 | |
HLPV-P08 | IgG1-Fc | 7.823×10-10 | 38.37 | |
HLPV-P09 | IgG1-Fc | 8.149×10-10 | 36.84 | |
HLPV-P10 | IgG1-Fc | 1.284×10-9 | 23.38 | |
HLPV-P11 | IgG1-Fc | 7.414×10-10 | 40.49 | |
HLPV-P12 | IgG1-Fc | 7.317×10-9 | 4.10 | |
HLPV-P13 | IgG1-Fc | 3.230×10-9 | 9.29 | |
HLPV-P14 | IgG1-Fc | 3.499×10-9 | 8.58 |
Claims (10)
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Citations (2)
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WO2010033913A1 (en) * | 2008-09-22 | 2010-03-25 | Icb International, Inc. | Antibodies, analogs and uses thereof |
CN108997497A (zh) * | 2018-03-30 | 2018-12-14 | 苏州思坦维生物技术股份有限公司 | 特异结合人质膜膜泡关联蛋白pv-1的单克隆抗体及其制备方法与应用 |
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CN102153647B (zh) * | 2011-01-27 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗egfr人源化抗体l3-h3及其编码基因与应用 |
US9493552B2 (en) * | 2013-11-15 | 2016-11-15 | China Synthetic Rubber Corporation | Therapeutic biologic for treatment of hepatocellular carcinoma |
WO2017075173A2 (en) * | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibodies and conjugates |
AU2016344146A1 (en) * | 2015-10-30 | 2018-05-10 | Genentech, Inc. | Methods of measuring Factor D activity and potency of Factor D inhibitors |
CN105924524A (zh) * | 2016-04-23 | 2016-09-07 | 同济大学苏州研究院 | 抗c-Met嵌合抗体及应用 |
JP2022550832A (ja) * | 2019-09-30 | 2022-12-05 | 和▲ハク▼医▲薬▼(▲蘇▼州)有限公司 | Cd3を標的とする抗体、二重特異性抗体及びその使用 |
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WO2010033913A1 (en) * | 2008-09-22 | 2010-03-25 | Icb International, Inc. | Antibodies, analogs and uses thereof |
CN108997497A (zh) * | 2018-03-30 | 2018-12-14 | 苏州思坦维生物技术股份有限公司 | 特异结合人质膜膜泡关联蛋白pv-1的单克隆抗体及其制备方法与应用 |
US20210000969A1 (en) * | 2018-03-30 | 2021-01-07 | Hualan Genetic Engineering Co., Ltd. | Monoclonal antibody specifically binding to human plasmalemma vesicle-associated protein pv-1, preparation and use thereof |
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