CN116211949A - Aloe pearl capsule and preparation method thereof - Google Patents

Aloe pearl capsule and preparation method thereof Download PDF

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Publication number
CN116211949A
CN116211949A CN202210515270.0A CN202210515270A CN116211949A CN 116211949 A CN116211949 A CN 116211949A CN 202210515270 A CN202210515270 A CN 202210515270A CN 116211949 A CN116211949 A CN 116211949A
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Prior art keywords
aloe
pearl
parts
preparation
weight
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冯胜军
冯朝
尉杰
李伟
鲁延清
郭峰
王红杰
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Hebei Junlin Pharmaceutical Co ltd
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Hebei Junlin Pharmaceutical Co ltd
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    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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Abstract

The invention provides an aloe pearl capsule and a preparation method thereof, wherein the aloe pearl capsule comprises the following components: 100 parts of aloe, 450-550 parts of costustoot and 45-55 parts of pearl; the aloe pearl capsules provided by the invention are prepared in a reasonable relationship and have a specific proportion, and are beneficial to the effects of clearing the intestines and defecating, improving the intestinal tracts and promoting the peristalsis of the intestines and the stomach. The aloe, the costustoot and the pearl are mixed according to the ratio of 2:10:1, so that the health care effect can be achieved when the patient has the effects of promoting digestion, resolving food stagnation, resolving phlegm and heat, clearing heat and detoxicating, and treating constipation.

Description

Aloe pearl capsule and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an aloe pearl capsule and a preparation method thereof
Background
Constipation refers to the reduction of defecation times, difficulty in defecation and dry feces; the defecation times per week are less than 3 times, and the disease course is more than 6 months. The prevalence rate of chronic constipation for adults in China is 4-6%, and the prevalence rate of chronic constipation for people over 60 years old is 22%. The causes of chronic constipation are numerous, including: reduced daily activity, increased mental stress, insufficient fiber or fluid intake due to unbalanced diet, reduced intestinal peristalsis due to reduced body function, atrophy of intestinal mucosa and intestinal wall fibers, etc. The prevalence rate of constipation of the elderly is obviously increased in younger and older people, mainly because with the increase of age, the food intake and physical activity of the elderly are obviously reduced, gastrointestinal secretion digestive juice is reduced, tension and peristalsis of intestinal tracts are weakened, abdominal cavity and pelvic floor muscles are weakened, internal and external sphincter anus is weakened, gastric colon reflection is weakened, rectal sensitivity is reduced, food stays in the intestines for too long, and excessive moisture absorption causes constipation.
In terms of treatment, at present, most Western medicine adopts permeability, irritation and lubricating laxatives (such as lactulose, enema, polyethylene glycol and the like) and secretagogues and prokinetic medicines, but the adverse effects of medicine treatment are more, and long-term administration is easy to generate dependence and influence the absorption of calcium, phosphorus and fat-soluble vitamins, and the long-term administration of the irritation laxative can cause irreversible enteric nerve damage.
Disclosure of Invention
The invention aims to overcome the defects and provide the traditional Chinese medicine composition aloe pearl capsules with good curative effect and small side effect and the preparation method thereof.
In a first aspect of the invention, there is provided an aloe pearl capsule comprising the following components by weight:
component (A) Parts by weight
Aloe vera 100 parts of
Radix aucklandiae 450-550 parts
Pearl 45-55 parts
Preferably, the composition comprises the following components in weight:
component (A) Parts by weight
Aloe vera 100 parts of
Radix aucklandiae 490-505
Pearl 49-51 parts
More preferably, the composition comprises the following components in weight:
component (A) Parts by weight
Aloe vera 100 parts of
Radix aucklandiae 500 parts of
Pearl 50 parts of
Furthermore, the aloe pearl capsule also comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials are preferably corn starch, lecithin and beta-cyclodextrin; the beta-cyclodextrin is preferably sulfobutyl beta-cyclodextrin.
Further, the weight of the sulfobutylcyclodextrin is 0.2-0.3 times, preferably 0.26-0.28 times of the weight of the costustoot.
The second aspect of the invention provides a preparation method of the aloe pearl capsule.
A preparation method of aloe pearl capsule comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: crushing radix aucklandiae, soaking in 7-10 times of water for 3-5 hr, adding lecithin, extracting volatile oil by steam distillation for 1-2 hr, adding sodium bicarbonate to adjust pH to 8.0-8.5, adding alkaline protease, steam distilling for 1-2 hr, adding flavourzyme, steam distilling for 1-2 hr, collecting volatile oil, clathrating with sulfobutyl betacyclodextrin, and collecting clathrate. Filtering the extracting solution, and concentrating to obtain fluid extract (called costustoot fluid extract for short) with the relative density of 1.2-1.3.
Preparation of aloe extract: pulverizing aloe, reflux extracting with 3 times of 75-85% ethanol for 0.2-1.0 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.15-1.20 (aloe fluid extract for short).
Preparing pearl powder: pulverizing Margarita to obtain Margarita powder with D90 of not more than 28 μm.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the content of the capsule prepared in the step (2) to obtain the aloe pearl capsule.
Wherein, the liquid crystal display device comprises a liquid crystal display device,
the weight of lecithin is 0.01-0.1 times, preferably 0.06 times of the weight of radix aucklandiae.
The alkaline protease is 0.02-0.06 times, preferably 0.04 times of the weight of radix aucklandiae.
The weight of the flavourzyme is 0.08-0.15 times of the weight of the costustoot, preferably 0.12 times.
Compared with the prior art, the invention has the following beneficial effects:
(1) The raw materials are safer; the aloe, the costustoot, the pearl and the like are used as components for treating constipation, so that the raw materials are safe to use; animal tests and crowd trial prove that the aloe pearl capsules can treat constipation, promote defecation of patients and have no toxic or side effect.
(2) The aloe pearl capsules provided by the invention are prepared in a reasonable relationship and have a specific proportion, and are beneficial to the effects of clearing the intestines and defecating, improving the intestinal tracts and promoting the peristalsis of the intestines and the stomach. The aloe, the costustoot and the pearl are mixed according to the ratio of 2:10:1, so that the health care effect can be achieved when the patient has the effects of promoting digestion, resolving food stagnation, resolving phlegm and heat, clearing heat and detoxicating, and treating constipation.
(3) According to the preparation method provided by the invention, the components in the raw materials are processed respectively, so that mutual interference among the raw materials is avoided, the drug effect of the raw materials is brought into play, particularly the elecampane is extracted by adopting a specific method, the obtained volatile oil and the extracting solution are utilized, the effects of the volatile oil and the extracting solution are fully brought into play, and unexpected technical effects are achieved.
Detailed Description
The invention discloses an aloe pearl capsule and a preparation method thereof, and the aloe pearl capsule can be realized by combining the related principles of medicine extraction and medicine preparation by combining the content of the invention with proper improvement of technological parameters by a person skilled in the art. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and are deemed to be included within the scope of the present invention. While the invention has been described with reference to preferred embodiments, it will be apparent to those skilled in the relevant art that variations and modifications can be made in the methods and applications described herein, or in appropriate changes and combinations, without departing from the spirit and scope of the invention.
For a better understanding of the present invention, and not to limit its scope, all numbers expressing quantities, percentages, and other values used in the present application are to be understood as being modified in all instances by the term "about". Each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
The invention is further illustrated by the following examples, which are not intended to limit the invention in any way.
Example 1: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 500 parts of 500
Pearl 50 parts of 50
Sulfobutyl betacyclodextrin 130 parts of 130
Corn starch 200 parts of 200
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.5 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.18 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 15 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 2: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 500 parts of 500
Pearl 50 parts of 50
Sulfobutyl betacyclodextrin 140 parts 140
Corn starch 200 parts of 200
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: crushing radix aucklandiae, adding 9 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.2, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1-2 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.27 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.6 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.17 (aloe fluid extract for short).
Preparing pearl powder: pulverizing Margarita to obtain Margarita powder with D90 of 18 μm.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 3: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 490 parts of 490
Pearl 49 parts of 49
Sulfobutyl betacyclodextrin 120 parts of 120
Corn starch 200 parts of 200
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 25g (25 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.1, adding 25g (25 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 65g (65 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.22 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.4 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.18 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 20.5 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 4: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 505 parts 505
Pearl 51 parts of 51
Sulfobutyl betacyclodextrin 110 parts of 110
Corn starch 200 parts of 200
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the costustoot, adding 9 times of water, soaking for 4 hours, adding 35g (35 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.4, adding 15g (15 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 55g (55 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting the volatile oil, clathrating the volatile oil by sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.28 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.7 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.19 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 21 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 5: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 450 parts of 450
Pearl 55 parts of 55
Sulfobutyl betacyclodextrin 100 parts of 100
Corn starch 200 parts of 200
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the costustoot, adding 7 times of water, soaking for 5 hours, adding 45g (45 parts) of lecithin, extracting volatile oil by a steam distillation method for 1 hour, adding sodium bicarbonate to adjust the pH to be 8, adding 11g (11 parts) of alkaline protease, continuing steam distillation for 1 hour, adding 67g (67 parts) of flavourzyme, continuing steam distillation for 1 hour, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.21 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 75% ethanol for 0.3 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.2 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 26 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 6: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 550 parts 550
Pearl 45 parts of 45
Sulfobutyl betacyclodextrin 100 parts of 100
Corn starch 200 parts of 200
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 10 times of water, soaking for 3 hours, adding 22g (22 parts) of lecithin, extracting volatile oil by a steam distillation method for 2 hours, adding sodium bicarbonate to adjust the pH to 8.5, adding 27g (27 parts) of alkaline protease, continuing steam distillation for 2 hours, adding 44g (44 parts) of flavourzyme, continuing steam distillation for 2 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.26 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 85% ethanol for 1 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.15 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 27.1 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Comparative example 1: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 300 parts of 300
Radix aucklandiae 300 parts of 300
Pearl 50 parts of 50
Sulfobutyl betacyclodextrin 130 parts of 130
Corn starch 200 parts of 200
The preparation method comprises the following steps: as in example 1.
Comparative example 2: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 500 parts of 500
Radix aucklandiae 100 parts of 100
Pearl 50 parts of 50
Sulfobutyl betacyclodextrin 130 parts of 130
Corn starch 200 parts of 200
The preparation method comprises the following steps: as in example 1.
Comparative example 3: aloe pearl capsule
Component (A) Parts by weight Weight (g)
Aloe vera 100 parts of 100
Radix aucklandiae 500 parts of 500
Pearl 50 parts of 50
Sulfobutyl betacyclodextrin 50 parts of 50
Corn starch 200 parts of 200
The preparation method comprises the following steps: same as in example 1
Comparative example 4: aloe pearl capsule
The components are as follows: as in example 1.
Comparative example 4-1: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 188 g (30 parts) of poloxamer, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to be 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Comparative example 4-2: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to be 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting the volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Comparative example 5: aloe pearl capsule
The components are as follows: as in example 1.
Comparative example 5-1: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
Preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 3.0 hours, adding 60g (60 parts) of flavourzyme, continuously steam distilling for 1.5 hours, collecting the volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and keeping the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Comparative example 5-2: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
Preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 3.0 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Example 7: effect evaluation:
1. test design
Male C57BL/6 mice, weighing 20-30g, 10 in each group, 150 in total. Divided into 15 groups
Wherein 140 mice are filled with the stomach molding drug loperamide hydrochloride with the dosage of 50mg/Kg, and the stomach is continuously filled for 7 days, so as to establish a mouse intestinal constipation model. Another 10 blank groups;
test article: 13 groups of aloe pearl capsules prepared in examples 1-6 and comparative examples 1-5 are prepared, and the model control group does not take any medicine; the doses were 2.5g (aloe pearl capsule content)/kg (mice), respectively, and the administration was performed once daily for 5 days.
Observing the first defecation time (min) and the weight (g) of the excrement
2. Test results
Group of First defecation time (min) Fecal weight (g)
Blank control group 208.4±31.59## 0.87±0.17##
Model control group 295.8±44.87** 0.50±0.24**
Example 1 212.8±32.39## 0.83±0.23##
Example 2 217.7±33.32## 0.72±0.23##
Example 3 206.4±30.31## 0.71±0.21##
Example 4 221.2±33.11## 0.62±0.25##
Example 5 243.7±36.83#★ 0.61±0.17#
Example 6 244.5±37.53#★ 0.44±0.07#
Comparative example 1 210.4±32.15## 0.49±0.13★★
Comparative example 2 230.0±34.04## 0.50±0.07★★
Comparative example 3 268.0±41.02★★ 0.51±0.07★★
Comparative example 4-1 280.7±42.64★★ 0.54±0.16★★
Comparative example 4-2 270.3±40.11★★ 0.55±0.15★★
Comparative example 5-1 279.0±41.49★★ 0.52±0.09★★
Comparative example 5-2 274.3±40.72★★ 0.52±0.22★★
Note that: #p <0.05; # P <0.01; compared with the model group
* P <0.05; * P <0.01; compared with the blank control group
P <0.05; p <0.01; compared with the group of the embodiment 1
(1) Compared with the blank control group, the first defecation time of the model group is obviously increased, the weight of excrement is obviously reduced, and the two have very obvious difference (P is less than 0.01), which indicates that the model is successful.
(2) Compared with a model control group, the aloe pearl capsules prepared in examples 1-6 can remarkably reduce the first defecation time and improve the weight of excrement, and have remarkable differences (P is less than 0.01 or P is less than 0.05), which indicates that the aloe pearl capsules prepared in examples 1-6 treat constipation.
(3) Compared with a model control group, the aloe pearl capsules prepared in the comparative examples 1-2 can remarkably reduce the first defecation time, and the difference is very remarkable (P is less than 0.01), and the weight of excrement is improved but not remarkable (P is more than 0.05), so that the aloe pearl capsules prepared in the comparative examples 1-2 cannot be used for treating constipation.
(4) Compared with the model control group, the aloe pearl capsules prepared in the comparative examples 3-5 can reduce the first defecation time and improve the fecal weight, but have no significant difference (P > 0.05), which indicates that the aloe pearl capsules prepared in the comparative examples 3-5 can not be used for treating constipation.
(4) Compared with the group of the example 1, the aloe pearl capsules prepared in the comparative examples 1-2 can reduce the first defecation time without significant difference (P is more than 0.05), which shows that the aloe pearl capsules are convenient to reduce the first defecation time and are similar to the group of the example 1; however, the aloe pearl capsules prepared in comparative examples 1-2 have very significant differences in increasing the weight of feces (P < 0.01), which indicates that the aloe pearl capsules prepared in comparative examples 1-2 have significantly poorer constipation treating effect than the aloe pearl capsules prepared in example 1, and have very significant differences (P < 0.01).
(4) Compared with the group of the example 1, the aloe pearl capsules prepared in the comparative examples 3-5 can reduce the first defecation time and improve the fecal weight, but all have very significant differences (P < 0.01), which indicates that the aloe pearl capsules prepared in the comparative examples 3-5 have significantly worse constipation treating effect than the group of the example 1 and very significant differences (P < 0.01)
Therefore, only the aloe, the costustoot and the pearl are extracted according to a specific proportion in a proportion mode of 2:10:1 by adopting a specific method, particularly the costustoot, the volatile oil and the extracting solution are both utilized, and the prepared aloe pearl capsule can effectively treat constipation.

Claims (9)

1. An aloe pearl capsule comprises the following components in parts by weight:
Figure FDA0003639262310000011
2. the aloe pearl capsule according to claim 1, which comprises the following components
Figure FDA0003639262310000012
3. The aloe pearl capsule according to claim 2, which comprises the following components:
Figure FDA0003639262310000013
4. the aloe pearl capsule according to claim 3, further comprising pharmaceutically acceptable excipients, preferably corn starch, lecithin, betacyclodextrin; the beta-cyclodextrin is preferably sulfobutyl beta-cyclodextrin.
5. The aloe pearl capsule according to claim 4, wherein said sulfobutylcyclodextrin is 0.2 to 0.3 times, preferably 0.26 to 0.28 times the weight of banksia rose.
6. A method of preparing the aloe pearl capsule according to claim 5, comprising the steps of:
(1) Pretreatment:
preparation of the costustoot extract: crushing radix aucklandiae, adding 7-10 times of water, soaking for 3-5 hours, adding lecithin, extracting volatile oil by a steam distillation method for 1-2 hours, adding sodium bicarbonate to adjust the pH to 8.0-8.5, adding alkaline protease, continuing steam distillation for 1-2 hours, adding flavourzyme, continuing steam distillation for 1-2 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and keeping the clathrate for later use; filtering the extracting solution, and concentrating to obtain clear paste with the relative density of 1.2-1.3;
preparation of aloe extract: pulverizing aloe, reflux extracting with 3 times of 75-85% ethanol for 0.2-1.0 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.15-1.20;
preparing pearl powder: pulverizing Margarita to obtain Margarita powder with D90 of not more than 28 μm;
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring;
(3) Preparation of aloe pearl capsules: and (3) subpackaging the content of the capsule prepared in the step (2) to obtain the aloe pearl capsule.
7. The method according to claim 6, wherein the weight of lecithin is 0.01 to 0.1 times the weight of banksia rose; preferably 0.06 times.
8. The method according to claim 6, wherein the alkaline protease is 0.02 to 0.06 times by weight of the costustoot; preferably 0.04 times.
9. The method of claim 6, wherein the flavourzyme is 0.08-0.15 times the weight of banksia rose; preferably 0.12 times.
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