CN116211949A - Aloe pearl capsule and preparation method thereof - Google Patents
Aloe pearl capsule and preparation method thereof Download PDFInfo
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- CN116211949A CN116211949A CN202210515270.0A CN202210515270A CN116211949A CN 116211949 A CN116211949 A CN 116211949A CN 202210515270 A CN202210515270 A CN 202210515270A CN 116211949 A CN116211949 A CN 116211949A
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- aloe
- pearl
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- 235000011399 aloe vera Nutrition 0.000 title claims abstract description 104
- 241001116389 Aloe Species 0.000 title claims abstract description 92
- 239000002775 capsule Substances 0.000 title claims abstract description 86
- 238000002360 preparation method Methods 0.000 title claims abstract description 61
- 239000012530 fluid Substances 0.000 claims description 54
- 239000000341 volatile oil Substances 0.000 claims description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000843 powder Substances 0.000 claims description 32
- 238000001256 steam distillation Methods 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 28
- 229920000858 Cyclodextrin Polymers 0.000 claims description 27
- 239000001116 FEMA 4028 Substances 0.000 claims description 27
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 27
- 229960004853 betadex Drugs 0.000 claims description 27
- 238000010298 pulverizing process Methods 0.000 claims description 24
- -1 sulfobutyl beta-cyclodextrin Chemical compound 0.000 claims description 23
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 22
- 229920002261 Corn starch Polymers 0.000 claims description 19
- 239000008120 corn starch Substances 0.000 claims description 19
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 14
- 244000293323 Cosmos caudatus Species 0.000 claims description 14
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 14
- 108010007119 flavourzyme Proteins 0.000 claims description 14
- 235000010445 lecithin Nutrition 0.000 claims description 14
- 229940067606 lecithin Drugs 0.000 claims description 14
- 239000000787 lecithin Substances 0.000 claims description 14
- 108091005658 Basic proteases Proteins 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 12
- 238000002791 soaking Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 11
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 11
- 229940069521 aloe extract Drugs 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 229940099112 cornstarch Drugs 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 241001647745 Banksia Species 0.000 claims 3
- 241000220317 Rosa Species 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 16
- 210000000936 intestine Anatomy 0.000 abstract description 5
- 230000008855 peristalsis Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 2
- 230000029087 digestion Effects 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 208000026435 phlegm Diseases 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 26
- 230000013872 defecation Effects 0.000 description 13
- 244000144927 Aloe barbadensis Species 0.000 description 12
- 235000002961 Aloe barbadensis Nutrition 0.000 description 12
- 239000003814 drug Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 3
- 230000002550 fecal effect Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- OHVLMTFVQDZYHP-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CN1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O OHVLMTFVQDZYHP-UHFFFAOYSA-N 0.000 description 2
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 2
- JQMFQLVAJGZSQS-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-N-(2-oxo-3H-1,3-benzoxazol-6-yl)acetamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)NC1=CC2=C(NC(O2)=O)C=C1 JQMFQLVAJGZSQS-UHFFFAOYSA-N 0.000 description 2
- CONKBQPVFMXDOV-QHCPKHFHSA-N 6-[(5S)-5-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-2-oxo-1,3-oxazolidin-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C[C@H]1CN(C(O1)=O)C1=CC2=C(NC(O2)=O)C=C1 CONKBQPVFMXDOV-QHCPKHFHSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000008141 laxative Substances 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 244000116484 Inula helenium Species 0.000 description 1
- 235000002598 Inula helenium Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 229960002983 loperamide hydrochloride Drugs 0.000 description 1
- PGYPOBZJRVSMDS-UHFFFAOYSA-N loperamide hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 PGYPOBZJRVSMDS-UHFFFAOYSA-N 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 210000003903 pelvic floor Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000580 secretagogue effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention provides an aloe pearl capsule and a preparation method thereof, wherein the aloe pearl capsule comprises the following components: 100 parts of aloe, 450-550 parts of costustoot and 45-55 parts of pearl; the aloe pearl capsules provided by the invention are prepared in a reasonable relationship and have a specific proportion, and are beneficial to the effects of clearing the intestines and defecating, improving the intestinal tracts and promoting the peristalsis of the intestines and the stomach. The aloe, the costustoot and the pearl are mixed according to the ratio of 2:10:1, so that the health care effect can be achieved when the patient has the effects of promoting digestion, resolving food stagnation, resolving phlegm and heat, clearing heat and detoxicating, and treating constipation.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an aloe pearl capsule and a preparation method thereof
Background
Constipation refers to the reduction of defecation times, difficulty in defecation and dry feces; the defecation times per week are less than 3 times, and the disease course is more than 6 months. The prevalence rate of chronic constipation for adults in China is 4-6%, and the prevalence rate of chronic constipation for people over 60 years old is 22%. The causes of chronic constipation are numerous, including: reduced daily activity, increased mental stress, insufficient fiber or fluid intake due to unbalanced diet, reduced intestinal peristalsis due to reduced body function, atrophy of intestinal mucosa and intestinal wall fibers, etc. The prevalence rate of constipation of the elderly is obviously increased in younger and older people, mainly because with the increase of age, the food intake and physical activity of the elderly are obviously reduced, gastrointestinal secretion digestive juice is reduced, tension and peristalsis of intestinal tracts are weakened, abdominal cavity and pelvic floor muscles are weakened, internal and external sphincter anus is weakened, gastric colon reflection is weakened, rectal sensitivity is reduced, food stays in the intestines for too long, and excessive moisture absorption causes constipation.
In terms of treatment, at present, most Western medicine adopts permeability, irritation and lubricating laxatives (such as lactulose, enema, polyethylene glycol and the like) and secretagogues and prokinetic medicines, but the adverse effects of medicine treatment are more, and long-term administration is easy to generate dependence and influence the absorption of calcium, phosphorus and fat-soluble vitamins, and the long-term administration of the irritation laxative can cause irreversible enteric nerve damage.
Disclosure of Invention
The invention aims to overcome the defects and provide the traditional Chinese medicine composition aloe pearl capsules with good curative effect and small side effect and the preparation method thereof.
In a first aspect of the invention, there is provided an aloe pearl capsule comprising the following components by weight:
component (A) | Parts by weight |
Aloe vera | 100 parts of |
Radix aucklandiae | 450-550 parts |
Pearl | 45-55 parts |
Preferably, the composition comprises the following components in weight:
component (A) | Parts by weight |
Aloe vera | 100 parts of |
Radix aucklandiae | 490-505 |
Pearl | 49-51 parts |
More preferably, the composition comprises the following components in weight:
component (A) | Parts by weight |
Aloe vera | 100 parts of |
Radix aucklandiae | 500 parts of |
Pearl | 50 parts of |
Furthermore, the aloe pearl capsule also comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials are preferably corn starch, lecithin and beta-cyclodextrin; the beta-cyclodextrin is preferably sulfobutyl beta-cyclodextrin.
Further, the weight of the sulfobutylcyclodextrin is 0.2-0.3 times, preferably 0.26-0.28 times of the weight of the costustoot.
The second aspect of the invention provides a preparation method of the aloe pearl capsule.
A preparation method of aloe pearl capsule comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: crushing radix aucklandiae, soaking in 7-10 times of water for 3-5 hr, adding lecithin, extracting volatile oil by steam distillation for 1-2 hr, adding sodium bicarbonate to adjust pH to 8.0-8.5, adding alkaline protease, steam distilling for 1-2 hr, adding flavourzyme, steam distilling for 1-2 hr, collecting volatile oil, clathrating with sulfobutyl betacyclodextrin, and collecting clathrate. Filtering the extracting solution, and concentrating to obtain fluid extract (called costustoot fluid extract for short) with the relative density of 1.2-1.3.
Preparation of aloe extract: pulverizing aloe, reflux extracting with 3 times of 75-85% ethanol for 0.2-1.0 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.15-1.20 (aloe fluid extract for short).
Preparing pearl powder: pulverizing Margarita to obtain Margarita powder with D90 of not more than 28 μm.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the content of the capsule prepared in the step (2) to obtain the aloe pearl capsule.
Wherein, the liquid crystal display device comprises a liquid crystal display device,
the weight of lecithin is 0.01-0.1 times, preferably 0.06 times of the weight of radix aucklandiae.
The alkaline protease is 0.02-0.06 times, preferably 0.04 times of the weight of radix aucklandiae.
The weight of the flavourzyme is 0.08-0.15 times of the weight of the costustoot, preferably 0.12 times.
Compared with the prior art, the invention has the following beneficial effects:
(1) The raw materials are safer; the aloe, the costustoot, the pearl and the like are used as components for treating constipation, so that the raw materials are safe to use; animal tests and crowd trial prove that the aloe pearl capsules can treat constipation, promote defecation of patients and have no toxic or side effect.
(2) The aloe pearl capsules provided by the invention are prepared in a reasonable relationship and have a specific proportion, and are beneficial to the effects of clearing the intestines and defecating, improving the intestinal tracts and promoting the peristalsis of the intestines and the stomach. The aloe, the costustoot and the pearl are mixed according to the ratio of 2:10:1, so that the health care effect can be achieved when the patient has the effects of promoting digestion, resolving food stagnation, resolving phlegm and heat, clearing heat and detoxicating, and treating constipation.
(3) According to the preparation method provided by the invention, the components in the raw materials are processed respectively, so that mutual interference among the raw materials is avoided, the drug effect of the raw materials is brought into play, particularly the elecampane is extracted by adopting a specific method, the obtained volatile oil and the extracting solution are utilized, the effects of the volatile oil and the extracting solution are fully brought into play, and unexpected technical effects are achieved.
Detailed Description
The invention discloses an aloe pearl capsule and a preparation method thereof, and the aloe pearl capsule can be realized by combining the related principles of medicine extraction and medicine preparation by combining the content of the invention with proper improvement of technological parameters by a person skilled in the art. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and are deemed to be included within the scope of the present invention. While the invention has been described with reference to preferred embodiments, it will be apparent to those skilled in the relevant art that variations and modifications can be made in the methods and applications described herein, or in appropriate changes and combinations, without departing from the spirit and scope of the invention.
For a better understanding of the present invention, and not to limit its scope, all numbers expressing quantities, percentages, and other values used in the present application are to be understood as being modified in all instances by the term "about". Each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
The invention is further illustrated by the following examples, which are not intended to limit the invention in any way.
Example 1: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 500 parts of | 500 |
Pearl | 50 parts of | 50 |
Sulfobutyl betacyclodextrin | 130 parts of | 130 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.5 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.18 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 15 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 2: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 500 parts of | 500 |
Pearl | 50 parts of | 50 |
Sulfobutyl betacyclodextrin | 140 parts | 140 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: crushing radix aucklandiae, adding 9 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.2, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1-2 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.27 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.6 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.17 (aloe fluid extract for short).
Preparing pearl powder: pulverizing Margarita to obtain Margarita powder with D90 of 18 μm.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 3: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 490 parts of | 490 |
Pearl | 49 parts of | 49 |
Sulfobutyl betacyclodextrin | 120 parts of | 120 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 25g (25 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.1, adding 25g (25 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 65g (65 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.22 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.4 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.18 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 20.5 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 4: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 505 parts | 505 |
Pearl | 51 parts of | 51 |
Sulfobutyl betacyclodextrin | 110 parts of | 110 |
Corn starch | 200 parts of | 200 |
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the costustoot, adding 9 times of water, soaking for 4 hours, adding 35g (35 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.4, adding 15g (15 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 55g (55 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting the volatile oil, clathrating the volatile oil by sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.28 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 80% ethanol for 0.7 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.19 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 21 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 5: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 450 parts of | 450 |
Pearl | 55 parts of | 55 |
Sulfobutyl betacyclodextrin | 100 parts of | 100 |
Corn starch | 200 parts of | 200 |
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the costustoot, adding 7 times of water, soaking for 5 hours, adding 45g (45 parts) of lecithin, extracting volatile oil by a steam distillation method for 1 hour, adding sodium bicarbonate to adjust the pH to be 8, adding 11g (11 parts) of alkaline protease, continuing steam distillation for 1 hour, adding 67g (67 parts) of flavourzyme, continuing steam distillation for 1 hour, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.21 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 75% ethanol for 0.3 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.2 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 26 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Example 6: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 550 parts | 550 |
Pearl | 45 parts of | 45 |
Sulfobutyl betacyclodextrin | 100 parts of | 100 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps:
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 10 times of water, soaking for 3 hours, adding 22g (22 parts) of lecithin, extracting volatile oil by a steam distillation method for 2 hours, adding sodium bicarbonate to adjust the pH to 8.5, adding 27g (27 parts) of alkaline protease, continuing steam distillation for 2 hours, adding 44g (44 parts) of flavourzyme, continuing steam distillation for 2 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.26 (radix aucklandiae fluid extract for short).
Preparation of aloe extract: pulverizing Aloe, reflux-extracting with 3 times of 85% ethanol for 1 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.15 (aloe fluid extract for short).
Preparing pearl powder: the pearl powder with D90 of 27.1 μm is obtained by pulverizing the pearl.
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring.
(3) Preparation of aloe pearl capsules: and (3) subpackaging the capsule content prepared in the step (2) to obtain aloe pearl capsules (1000 capsules).
Comparative example 1: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 300 parts of | 300 |
Radix aucklandiae | 300 parts of | 300 |
Pearl | 50 parts of | 50 |
Sulfobutyl betacyclodextrin | 130 parts of | 130 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps: as in example 1.
Comparative example 2: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 500 parts of | 500 |
Radix aucklandiae | 100 parts of | 100 |
Pearl | 50 parts of | 50 |
Sulfobutyl betacyclodextrin | 130 parts of | 130 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps: as in example 1.
Comparative example 3: aloe pearl capsule
Component (A) | Parts by weight | Weight (g) |
Aloe vera | 100 parts of | 100 |
Radix aucklandiae | 500 parts of | 500 |
Pearl | 50 parts of | 50 |
Sulfobutyl betacyclodextrin | 50 parts of | 50 |
Corn starch | 200 parts of | 200 |
The preparation method comprises the following steps: same as in example 1
Comparative example 4: aloe pearl capsule
The components are as follows: as in example 1.
Comparative example 4-1: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 188 g (30 parts) of poloxamer, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to be 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Comparative example 4-2: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
(1) Pretreatment:
preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to be 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 1.5 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting the volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Comparative example 5: aloe pearl capsule
The components are as follows: as in example 1.
Comparative example 5-1: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
Preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 3.0 hours, adding 60g (60 parts) of flavourzyme, continuously steam distilling for 1.5 hours, collecting the volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and keeping the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Comparative example 5-2: the preparation method comprises the following steps: the preparation of the costustoot extract in the step (1) is as follows, with the remainder being as in example 1.
Preparation of the costustoot extract: the method comprises the steps of crushing the radix aucklandiae, adding 8 times of water, soaking for 4 hours, adding 30g (30 parts) of lecithin, extracting volatile oil by a steam distillation method for 1.5 hours, adding sodium bicarbonate to adjust the pH to 8.3, adding 20g (20 parts) of alkaline protease, continuing steam distillation for 3.0 hours, adding 60g (60 parts) of flavourzyme, continuing steam distillation for 1.5 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and standing the clathrate for later use. Filtering the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 (radix aucklandiae fluid extract for short).
Example 7: effect evaluation:
1. test design
Male C57BL/6 mice, weighing 20-30g, 10 in each group, 150 in total. Divided into 15 groups
Wherein 140 mice are filled with the stomach molding drug loperamide hydrochloride with the dosage of 50mg/Kg, and the stomach is continuously filled for 7 days, so as to establish a mouse intestinal constipation model. Another 10 blank groups;
test article: 13 groups of aloe pearl capsules prepared in examples 1-6 and comparative examples 1-5 are prepared, and the model control group does not take any medicine; the doses were 2.5g (aloe pearl capsule content)/kg (mice), respectively, and the administration was performed once daily for 5 days.
Observing the first defecation time (min) and the weight (g) of the excrement
2. Test results
Group of | First defecation time (min) | Fecal weight (g) |
Blank control group | 208.4±31.59## | 0.87±0.17## |
Model control group | 295.8±44.87** | 0.50±0.24** |
Example 1 | 212.8±32.39## | 0.83±0.23## |
Example 2 | 217.7±33.32## | 0.72±0.23## |
Example 3 | 206.4±30.31## | 0.71±0.21## |
Example 4 | 221.2±33.11## | 0.62±0.25## |
Example 5 | 243.7±36.83#★ | 0.61±0.17# |
Example 6 | 244.5±37.53#★ | 0.44±0.07# |
Comparative example 1 | 210.4±32.15## | 0.49±0.13★★ |
Comparative example 2 | 230.0±34.04## | 0.50±0.07★★ |
Comparative example 3 | 268.0±41.02★★ | 0.51±0.07★★ |
Comparative example 4-1 | 280.7±42.64★★ | 0.54±0.16★★ |
Comparative example 4-2 | 270.3±40.11★★ | 0.55±0.15★★ |
Comparative example 5-1 | 279.0±41.49★★ | 0.52±0.09★★ |
Comparative example 5-2 | 274.3±40.72★★ | 0.52±0.22★★ |
Note that: #p <0.05; # P <0.01; compared with the model group
* P <0.05; * P <0.01; compared with the blank control group
P <0.05; p <0.01; compared with the group of the embodiment 1
(1) Compared with the blank control group, the first defecation time of the model group is obviously increased, the weight of excrement is obviously reduced, and the two have very obvious difference (P is less than 0.01), which indicates that the model is successful.
(2) Compared with a model control group, the aloe pearl capsules prepared in examples 1-6 can remarkably reduce the first defecation time and improve the weight of excrement, and have remarkable differences (P is less than 0.01 or P is less than 0.05), which indicates that the aloe pearl capsules prepared in examples 1-6 treat constipation.
(3) Compared with a model control group, the aloe pearl capsules prepared in the comparative examples 1-2 can remarkably reduce the first defecation time, and the difference is very remarkable (P is less than 0.01), and the weight of excrement is improved but not remarkable (P is more than 0.05), so that the aloe pearl capsules prepared in the comparative examples 1-2 cannot be used for treating constipation.
(4) Compared with the model control group, the aloe pearl capsules prepared in the comparative examples 3-5 can reduce the first defecation time and improve the fecal weight, but have no significant difference (P > 0.05), which indicates that the aloe pearl capsules prepared in the comparative examples 3-5 can not be used for treating constipation.
(4) Compared with the group of the example 1, the aloe pearl capsules prepared in the comparative examples 1-2 can reduce the first defecation time without significant difference (P is more than 0.05), which shows that the aloe pearl capsules are convenient to reduce the first defecation time and are similar to the group of the example 1; however, the aloe pearl capsules prepared in comparative examples 1-2 have very significant differences in increasing the weight of feces (P < 0.01), which indicates that the aloe pearl capsules prepared in comparative examples 1-2 have significantly poorer constipation treating effect than the aloe pearl capsules prepared in example 1, and have very significant differences (P < 0.01).
(4) Compared with the group of the example 1, the aloe pearl capsules prepared in the comparative examples 3-5 can reduce the first defecation time and improve the fecal weight, but all have very significant differences (P < 0.01), which indicates that the aloe pearl capsules prepared in the comparative examples 3-5 have significantly worse constipation treating effect than the group of the example 1 and very significant differences (P < 0.01)
Therefore, only the aloe, the costustoot and the pearl are extracted according to a specific proportion in a proportion mode of 2:10:1 by adopting a specific method, particularly the costustoot, the volatile oil and the extracting solution are both utilized, and the prepared aloe pearl capsule can effectively treat constipation.
Claims (9)
4. the aloe pearl capsule according to claim 3, further comprising pharmaceutically acceptable excipients, preferably corn starch, lecithin, betacyclodextrin; the beta-cyclodextrin is preferably sulfobutyl beta-cyclodextrin.
5. The aloe pearl capsule according to claim 4, wherein said sulfobutylcyclodextrin is 0.2 to 0.3 times, preferably 0.26 to 0.28 times the weight of banksia rose.
6. A method of preparing the aloe pearl capsule according to claim 5, comprising the steps of:
(1) Pretreatment:
preparation of the costustoot extract: crushing radix aucklandiae, adding 7-10 times of water, soaking for 3-5 hours, adding lecithin, extracting volatile oil by a steam distillation method for 1-2 hours, adding sodium bicarbonate to adjust the pH to 8.0-8.5, adding alkaline protease, continuing steam distillation for 1-2 hours, adding flavourzyme, continuing steam distillation for 1-2 hours, collecting volatile oil, clathrating the volatile oil with sulfobutyl betacyclodextrin, and keeping the clathrate for later use; filtering the extracting solution, and concentrating to obtain clear paste with the relative density of 1.2-1.3;
preparation of aloe extract: pulverizing aloe, reflux extracting with 3 times of 75-85% ethanol for 0.2-1.0 hr, centrifuging the extractive solution, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract with relative density of 1.15-1.20;
preparing pearl powder: pulverizing Margarita to obtain Margarita powder with D90 of not more than 28 μm;
(2) Preparation of the capsule contents:
mixing radix aucklandiae fluid extract, aloe fluid extract and Margarita powder, drying under reduced pressure, pulverizing into fine powder, adding clathrate and corn starch, and stirring;
(3) Preparation of aloe pearl capsules: and (3) subpackaging the content of the capsule prepared in the step (2) to obtain the aloe pearl capsule.
7. The method according to claim 6, wherein the weight of lecithin is 0.01 to 0.1 times the weight of banksia rose; preferably 0.06 times.
8. The method according to claim 6, wherein the alkaline protease is 0.02 to 0.06 times by weight of the costustoot; preferably 0.04 times.
9. The method of claim 6, wherein the flavourzyme is 0.08-0.15 times the weight of banksia rose; preferably 0.12 times.
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CN116763872A (en) * | 2023-07-20 | 2023-09-19 | 河北君临药业有限公司 | Aloe pearl capsule and preparation method thereof |
CN117338869A (en) * | 2023-11-22 | 2024-01-05 | 河北医科大学 | A Chinese medicinal capsule and its preparation method |
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