CN113170848A - Accurate medicated diet food therapy product for preventing and treating senile functional constipation and preparation method thereof - Google Patents
Accurate medicated diet food therapy product for preventing and treating senile functional constipation and preparation method thereof Download PDFInfo
- Publication number
- CN113170848A CN113170848A CN202110497923.2A CN202110497923A CN113170848A CN 113170848 A CN113170848 A CN 113170848A CN 202110497923 A CN202110497923 A CN 202110497923A CN 113170848 A CN113170848 A CN 113170848A
- Authority
- CN
- China
- Prior art keywords
- parts
- preventing
- functional constipation
- treating senile
- medicated diet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010010774 Constipation Diseases 0.000 title claims abstract description 83
- 235000005911 diet Nutrition 0.000 title claims abstract description 68
- 230000037213 diet Effects 0.000 title claims abstract description 63
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 51
- 235000013305 food Nutrition 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 241000167854 Bourreria succulenta Species 0.000 claims abstract description 37
- 241000612118 Samolus valerandi Species 0.000 claims abstract description 37
- 235000019693 cherries Nutrition 0.000 claims abstract description 37
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims abstract description 36
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims abstract description 36
- 235000004347 Perilla Nutrition 0.000 claims abstract description 35
- 244000183685 Citrus aurantium Species 0.000 claims abstract description 25
- 235000007716 Citrus aurantium Nutrition 0.000 claims abstract description 25
- 235000005976 Citrus sinensis Nutrition 0.000 claims abstract description 25
- 235000011347 Moringa oleifera Nutrition 0.000 claims abstract description 25
- 210000000582 semen Anatomy 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 24
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims abstract description 22
- 244000018633 Prunus armeniaca Species 0.000 claims abstract description 20
- 235000009827 Prunus armeniaca Nutrition 0.000 claims abstract description 20
- 239000000126 substance Substances 0.000 claims abstract description 17
- 239000001666 citrus aurantium l. flower Substances 0.000 claims abstract description 15
- 244000124853 Perilla frutescens Species 0.000 claims abstract 6
- 244000179886 Moringa oleifera Species 0.000 claims abstract 5
- 239000000047 product Substances 0.000 claims description 65
- 241000218236 Cannabis Species 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 25
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 25
- 239000000843 powder Substances 0.000 claims description 25
- 238000000605 extraction Methods 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 17
- 235000013361 beverage Nutrition 0.000 claims description 16
- 229920002774 Maltodextrin Polymers 0.000 claims description 14
- 239000005913 Maltodextrin Substances 0.000 claims description 14
- 229940035034 maltodextrin Drugs 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 235000004431 Linum usitatissimum Nutrition 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 9
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 235000011194 food seasoning agent Nutrition 0.000 claims description 6
- 229920002261 Corn starch Polymers 0.000 claims description 5
- 239000008120 corn starch Substances 0.000 claims description 5
- 230000000378 dietary effect Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 239000004278 EU approved seasoning Substances 0.000 claims description 4
- 241000209140 Triticum Species 0.000 claims description 4
- 235000021307 Triticum Nutrition 0.000 claims description 4
- 238000007908 dry granulation Methods 0.000 claims description 4
- 235000013312 flour Nutrition 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 2
- 240000006240 Linum usitatissimum Species 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000000968 intestinal effect Effects 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000007774 longterm Effects 0.000 abstract description 3
- 239000008143 stimulant laxative Substances 0.000 abstract description 3
- 241001116389 Aloe Species 0.000 abstract description 2
- 240000004980 Rheum officinale Species 0.000 abstract description 2
- 235000008081 Rheum officinale Nutrition 0.000 abstract description 2
- 235000011399 aloe vera Nutrition 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 240000004308 marijuana Species 0.000 abstract 1
- 241000229722 Perilla <angiosperm> Species 0.000 description 29
- 241000220215 Moringa Species 0.000 description 20
- 241000208202 Linaceae Species 0.000 description 11
- 244000144725 Amygdalus communis Species 0.000 description 6
- 235000003893 Prunus dulcis var amara Nutrition 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 230000013872 defecation Effects 0.000 description 4
- 239000008141 laxative Substances 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 235000010357 aspartame Nutrition 0.000 description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
- 229960003438 aspartame Drugs 0.000 description 3
- 239000000605 aspartame Substances 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 244000025596 Cassia laevigata Species 0.000 description 2
- 235000006693 Cassia laevigata Nutrition 0.000 description 2
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 102000055135 Vasoactive Intestinal Peptide Human genes 0.000 description 2
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229940118019 malondialdehyde Drugs 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 230000008855 peristalsis Effects 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000001543 purgative effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229940124513 senna glycoside Drugs 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- PEYUIKBAABKQKQ-AFHBHXEDSA-N (+)-sesamin Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-AFHBHXEDSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- ZKSZEJFBGODIJW-GMDXDWKASA-N (R)-prunasin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H](C#N)C1=CC=CC=C1 ZKSZEJFBGODIJW-GMDXDWKASA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- ZZMNWJVJUKMZJY-AFHBHXEDSA-N Sesamolin Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3OC2=CC=C3OCOC3=C2)=C1 ZZMNWJVJUKMZJY-AFHBHXEDSA-N 0.000 description 1
- ZZMNWJVJUKMZJY-UHFFFAOYSA-N Sesamolin Natural products C1=C2OCOC2=CC(C2OCC3C2COC3OC2=CC=C3OCOC3=C2)=C1 ZZMNWJVJUKMZJY-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 1
- 235000008714 apigenin Nutrition 0.000 description 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 1
- 229940117893 apigenin Drugs 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 235000007215 black sesame Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 239000000799 cathartic agent Substances 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000105 enteric nervous system Anatomy 0.000 description 1
- PEYUIKBAABKQKQ-UHFFFAOYSA-N epiasarinin Natural products C1=C2OCOC2=CC(C2OCC3C2COC3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-UHFFFAOYSA-N 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 150000002540 isothiocyanates Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- ZKSZEJFBGODIJW-UHFFFAOYSA-N passiedulin Natural products OC1C(O)C(O)C(CO)OC1OC(C#N)C1=CC=CC=C1 ZKSZEJFBGODIJW-UHFFFAOYSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000009745 pathological pathway Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 238000009702 powder compression Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BMXNUTUYWQWEFA-UHFFFAOYSA-N prunasin Natural products OCC1OC(O)C(O)C(O)C1OC(C#N)c2ccccc2 BMXNUTUYWQWEFA-UHFFFAOYSA-N 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- VRMHCMWQHAXTOR-CMOCDZPBSA-N sesamin Natural products C1=C2OCOC2=CC([C@@H]2OC[C@@]3(C)[C@H](C=4C=C5OCOC5=CC=4)OC[C@]32C)=C1 VRMHCMWQHAXTOR-CMOCDZPBSA-N 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
At present, most of common preparations for treating senile functional constipation contain medicines of stimulant laxatives such as rheum officinale and aloe, so long-term application is not claimed, the medicines belong to medicine products, the effects are single, and at present, no product aiming at functional constipation, which is homologous in medicine and food and can improve intestinal microecology, exists. The invention provides an accurate medicated diet food therapy product for preventing and treating senile functional constipation and a preparation method thereof, wherein the product comprises the following substances in parts by mass: 1-20 parts of moringa leaves, 1-20 parts of fructus cannabis, 1-15 parts of bunge cherry seeds, 1-15 parts of perilla seeds, 1-15 parts of semen cassiae, 1-15 parts of bitter apricot seeds, 1-10 parts of semen sesami nigrum, 1-15 parts of seville orange flowers, 0.5-3 parts of mannose oligomer and 1-5 parts of stachyose. The accurate medicated diet food therapy product for preventing and treating senile functional constipation provided by the invention can effectively prevent and treat senile functional constipation, and meanwhile, the cost of the product is low, so that the product meets the requirement of industrialized production.
Description
Technical Field
The invention belongs to the technical field of medicated diet food therapy products, and particularly relates to an accurate medicated diet food therapy product for preventing and treating senile functional constipation and a preparation method thereof.
Background
Functional Constipation (FC) is a Functional intestinal disease caused by non-organic lesions, and has the main symptoms of reduced defecation frequency, difficult defecation, prolonged defecation period, incomplete defecation, and dry and hard feces. With the acceleration of modern life rhythm, the change of dietary structure, the influence of psychological, social factor, chronic constipation's patient is more and more. The prevalence rate of constipation of the general adult population in China reported in the literature at present is 3.19-11.6%. The long-term constipation can cause abnormal emotions such as anxiety, depression and the like, can secondary hemorrhoids and increase the risk of suffering from tumor and cardiovascular and cerebrovascular diseases, so that the research on the constipation is actively carried out, and the research significance is great.
The pathogenesis of constipation is complex and multifactorial, old people are degenerated due to multiple functions of organisms, basic diseases are more, the compliance of part of the old people to medicines is poor, particularly, the old people have a relatively refractory psychology to western medicines from a psychological perspective, and psychological stress is caused to the old people by adding medicines. In addition, prolonged abuse of cathartics can cause drug dependence, laxative colon, large intestine melanosis, etc. Functional constipation not only seriously reduces the life quality of the elderly, but also is related to the occurrence of colon cancer, senile dementia and cardiovascular and cerebrovascular accidents. The clinical treatment method for the disease is many, western medicine mostly adopts symptomatic treatment for the disease, but the treatment effect is not ideal, the adverse reaction is more, the dependence is easy to generate, and the damage of the enteric nerve endings is caused to aggravate the constipation symptom, and the medicines commonly used in clinic at present comprise (I) volume laxatives: magnesium sulfate, sodium sulfate, methyl cellulose, agar, etc.; ② stimulant laxatives: senna leaf, castor oil, diester phenol, etc.; ③ softening agent of excrement: liquid paraffin, lactulose, etc.; fourthly, intrarectal administration: glycerin suppository, glycerine enema, etc. The salt purgative (magnesium sulfate) is not easy to be absorbed in intestinal tract, remains in intestinal cavity to form hypertonic state, has strong cathartic effect and rapid catharsis effect, but causes serious adverse reaction, and should be used with caution clinically. Chronic use of pungent diarrhea (senna, phenolphthalein, castor oil, etc.) can damage the patient's enteric nervous system and is likely irreversible.
The traditional Chinese medicine has obvious characteristics and advantages in treating functional constipation, has few adverse reactions and has definite treatment effect. Can achieve the effects of improving the life quality of patients, reducing the dosage of western medicines and reducing side effects. At present, most of common preparations for treating senile functional constipation contain medicines of stimulant laxatives such as rheum officinale and aloe, so long-term application is not claimed, the medicines belong to medicine products, the effects are single, and at present, no product aiming at functional constipation, which is homologous in medicine and food and can improve intestinal microecology, exists.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an accurate medicated diet food therapy product for preventing and treating senile functional constipation and a preparation method thereof, and the accurate medicated diet food therapy product can effectively prevent and treat senile functional constipation.
The invention provides an accurate medicated diet food therapy product for preventing and treating senile functional constipation, which is prepared from the following substances in parts by mass: 1-20 parts of moringa leaves, 1-20 parts of fructus cannabis, 1-15 parts of bunge cherry seeds, 1-15 parts of perilla seeds, 1-15 parts of semen cassiae, 1-15 parts of bitter apricot seeds, 1-10 parts of semen sesami nigrum, 1-15 parts of seville orange flowers, 0.5-3 parts of mannose oligomer and 1-5 parts of stachyose.
Further, the accurate medicated diet food therapy product for preventing and treating senile functional constipation consists of the following substances in parts by mass: 6-12 parts of moringa leaves, 6-12 parts of fructus cannabis, 3-9 parts of bunge cherry seeds, 3-9 parts of perilla seeds, 3-9 parts of semen cassiae, 3-9 parts of bitter apricot seeds, 3-8 parts of semen sesami nigrum, 3-9 parts of seville orange flowers, 0.8-1.5 parts of mannose oligomer and 2-4 parts of stachyose.
Further, the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following substances in parts by mass: 9 parts of moringa leaves, 9 parts of fructus cannabis, 6 parts of bunge cherry seeds, 6 parts of perilla seeds, 6 parts of cassia seeds, 6 parts of bitter apricot seeds, 5 parts of flax, 6 parts of seville orange flowers, 1.0 part of mannose oligomer and 3 parts of stachyose.
Furthermore, the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises liquid beverage, oral liquid, solid beverage, granules and tablets.
The invention also comprises a preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding purified water, stachyose and mannose oligomer into the concentrated solution to obtain the accurate medicated diet therapy product liquid beverage for preventing and treating senile functional constipation.
Further, adding a proper amount of maltodextrin to the concentrated solution obtained in the step S1, and performing spray drying to obtain an extract; adding stachyose and oligomannose into the extract; adding flavoring and edible ingredients, mixing, packaging with a powder packaging machine, and packaging to obtain the accurate medicated diet dietetic product solid beverage for preventing and treating senile functional constipation.
Further, adding stachyose and mannose oligomer into the spray-dried extract powder, adding seasonings and auxiliary materials, granulating, drying and subpackaging to obtain the accurate medicinal diet therapy product granules for preventing and treating senile functional constipation;
further, adding stachyose and mannose oligomer into the spray-dried extract powder, adding one or more of maltodextrin, corn starch, wheat flour and protein powder, and performing dry granulation to obtain accurate medicated diet product granules for preventing and treating senile functional constipation;
further, adding the spray-dried extract powder into mannose oligomer and stachyose, adding seasonings and auxiliary materials, granulating, drying and tabletting to obtain the accurate medicated diet product tablet for preventing and treating senile functional constipation.
Further, adding stachyose and mannose oligomer into the spray-dried extract powder, adding one or more of maltodextrin, corn starch, wheat flour and protein powder, and directly tabletting the powder to obtain the accurate medicated diet product tablet for preventing and treating senile functional constipation.
The medicine mainly contains various kernels such as fructus cannabis, bunge cherry seed, bitter apricot seed and the like, has rich fatty oil, has the effects of lubricating intestinal walls, softening stool, slightly exciting intestinal canals, increasing peristalsis and reducing water absorbed by large intestine, has mild purgative force, and is commonly used for the old, the weak and the body fluid deficient constipation. In addition, flavonoids such as quercetin, apigenin and luteolin in fructus Cannabis, semen Pruni, semen Armeniacae amarum and fructus Perillae can stimulate Cystic Fibrosis Transmembrane Regulator (CFTR), open chloride channel, stimulate transepithelial Cl-secretion and make water migrate to colon. These and other intestinal neurotransmitter abnormalities exist in the colon of patients with functional constipation, and amygdalin in peach kernels and bunge cherry kernels, prunasin, anthraquinone substances in cassia seeds and the like can play a role in regulating gastrointestinal tract movement by influencing the release of serotonin (5-HT) and Vasoactive Intestinal Peptide (VIP) intestinal neurotransmitters. The oxidation-reduction reaction is also one of the mechanisms of constipation, isothiocyanate in radish seeds, sesamin and sesamolin in black sesame have strong antioxidant activity, the activity of superoxide dismutase (SOD) in serum can be obviously improved, the activity of Malondialdehyde (MDA) is obviously reduced, and the constipation is improved by enhancing the antioxidant and free radical scavenging capacity of the body. The bifidobacterium generated by the stachyose and the oligomannose has the effects of regulating intestinal bacteria and improving the intestinal micro-ecological environment, and simultaneously generates a large amount of short-chain fatty acid which can stimulate intestinal peristalsis, thereby achieving the effects of multi-component, multi-target, multi-path and multi-angle intervention on senile functional constipation and improvement on intestinal micro-ecology.
The invention adopts an accurate medicinal diet therapy product prepared from medicinal and edible medicinal materials, the network pharmacological research preliminarily determines relevant target points, effective components and action target points of the main diseases of patent prescriptions, determines the action relation network of main diseases-target points-medicinal effect components, determines the physiological/pathological pathway processes participating in the action, and simultaneously, the network research results of the components-target points-medicinal effect mechanisms of the formula are consistent with the connection of main diseases, thereby conforming to the modern accurate medical principle. Meanwhile, the product has low cost and meets the requirement of industrialized production.
Drawings
FIG. 1 is a diagram of network pharmacological research and pharmacological efficacy analysis of related Chinese herbs of the present invention.
Detailed Description
Example 1
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 1 part of moringa leaves, 20 parts of fructus cannabis, 15 parts of bunge cherry seeds, 1 part of perilla seeds, 15 parts of semen cassiae, 1 part of bitter almonds, 10 parts of semen sesami nigrum, 1 part of seville orange flowers, 3 parts of mannose oligomer and 1 part of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding purified water, stachyose and oligomannose into the concentrated solution according to the formula proportion, and adding potassium sorbate with the total mass ratio of 0.1% to obtain the accurate medicated diet therapy product liquid beverage for preventing and treating senile functional constipation.
Example 2
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 20 parts of moringa leaves, 1 part of fructus cannabis, 1 part of bunge cherry seed, 15 parts of perilla seeds, 1 part of cassia seeds, 15 parts of bitter apricot seeds, 1-10 parts of flax, 15 parts of seville orange flowers, 0.5 part of mannose oligomer and 5 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding maltodextrin 15 percent of the total mass of the concentrated solution obtained in the step S1, and carrying out spray drying to obtain an extract; adding stachyose and oligomannose into the spray-dried extract powder according to the proportion of the formula, adding aspartame seasoning accounting for 0.1 percent of the total mass, adding soluble starch auxiliary materials, granulating, drying and subpackaging to obtain the accurate medicinal diet therapy product granules for preventing and treating senile functional constipation.
Example 3
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 6 parts of moringa leaves, 12 parts of fructus cannabis, 3 parts of bunge cherry seeds, 9 parts of perilla seeds, 3 parts of semen cassiae, 9 parts of bitter almonds, 3 parts of semen sesami nigrum, 9 parts of seville orange flowers, 1.5 parts of mannose oligomer and 2 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding maltodextrin with the total mass of 20% into the concentrated solution obtained in the step S1, and carrying out spray drying to obtain an extract; adding the spray-dried extract powder into the low polymannan and stachyose according to the formula proportion, adding stevioside seasoning accounting for 0.05 percent of the total mass, adding protein powder auxiliary materials, granulating, drying and tabletting to obtain the accurate medicated diet product tablet for preventing and treating senile functional constipation.
Example 4
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 12 parts of moringa leaves, 6 parts of fructus cannabis, 9 parts of bunge cherry seeds, 3 parts of perilla seeds, 9 parts of semen cassiae, 3 parts of bitter almonds, 8 parts of semen sesami nigrum, 3 parts of seville orange flowers, 0.8 part of mannose oligomer and 4 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding maltodextrin 30 percent of the total mass of the concentrated solution obtained in the step S1, and carrying out spray drying to obtain an extract; adding stachyose and oligomannose into the spray-dried extract powder according to the formula proportion, adding 10% of corn starch by mass, and performing dry granulation to obtain the accurate medicinal diet therapy product granules for preventing and treating senile functional constipation.
Example 5
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 9 parts of moringa leaves, 9 parts of fructus cannabis, 6 parts of bunge cherry seeds, 6 parts of perilla seeds, 6 parts of semen cassiae, 6 parts of bitter almonds, 5 parts of semen sesami nigrum, 6 parts of seville orange flowers, 1 part of mannose oligomer and 3 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding a proper amount of maltodextrin with the total mass of 18% into the concentrated solution obtained in the step S1, and performing spray drying to obtain an extract; adding stachyose and oligomannose into the extract; adding aspartame flavoring agent with the total mass of 0.01 percent, adding maltodextrin, mixing uniformly, applying a powder packaging machine, and subpackaging to obtain the accurate medicated diet food therapy product solid beverage for preventing and treating senile functional constipation.
Example 6
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 3 parts of moringa leaves, 15 parts of fructus cannabis, 8 parts of bunge cherry seeds, 12 parts of perilla seeds, 10 parts of semen cassiae, 8 parts of bitter almonds, 6 parts of semen sesami nigrum, 10 parts of seville orange flowers, 2 parts of mannose oligomer and 2 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding 23% of maltodextrin in the total mass of the concentrated solution obtained in the step S1, and carrying out spray drying to obtain an extract; adding the spray-dried extract powder into the low polymannan and stachyose according to the formula proportion, adding the milk powder accounting for 5 percent of the total mass, taking the soluble starch as a filling agent, and adding the specified total amount to carry out direct powder compression, thus obtaining the accurate medicated diet product tablet for preventing and treating senile functional constipation.
Example 7
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 15 parts of moringa leaves, 10 parts of fructus cannabis, 10 parts of bunge cherry seeds, 7 parts of perilla seeds, 12 parts of semen cassiae, 10 parts of bitter almonds, 4 parts of semen sesami nigrum, 12 parts of seville orange flowers, 1.2 parts of mannose oligomer and 1-53 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding maltodextrin with the total mass of 25% into the concentrated solution obtained in the step S1, and carrying out spray drying to obtain an extract; adding stachyose and oligomannose into the extract; adding aspartame with the total mass ratio of 0.04 percent; adding lactose accounting for 15% of the total mass, adding maltodextrin, uniformly mixing, feeding into a powder packaging machine, and subpackaging to obtain the accurate medicated diet food therapy product solid beverage for preventing and treating senile functional constipation.
Example 8
An accurate medicated diet food therapy product for preventing and treating senile functional constipation, which comprises the following substances in parts by mass: 10 parts of moringa leaves, 5 parts of fructus cannabis, 12 parts of bunge cherry seeds, 10 parts of perilla seeds, 4 parts of cassia seeds, 12 parts of bitter apricot seeds, 2 parts of semen sesami nigrum, 5 parts of seville orange flowers, 2.5 parts of mannose oligomer and 4 parts of stachyose.
The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding purified water into the concentrated solution to a specified volume, adding stachyose and oligomannose according to the formula proportion, and adding sodium benzoate accounting for 0.03% of the total mass as a bacteriostatic agent to obtain the accurate medicated diet therapy product liquid beverage for preventing and treating senile functional constipation.
The liquid beverage of the invention is recommended to be orally taken for 2-3 times/day, and each time is 100-200 ml; the solid beverage is recommended to be taken 2-3 times a day, 10g of the solid beverage is taken each time, 100 ml of hot water is added, and the solid beverage is stirred until dissolved and can be eaten; the granule is taken 10-15g each time, and is added with 100 ml and 200ml hot water to be dissolved for eating; the tablet is taken 2-3 times per day, 15-20g of the product is taken each time.
In order to examine the improvement effect of the present invention on senile functional constipation, 240 volunteers were selected, and all had symptoms of constipation degree of different degree, dryness, and stooling once for several days. Subjects were randomized into 8 groups of 30 individuals and were administered the present invention in example 1, example 2, example 3, example 4, example 5, example 6, example 7, example 8, respectively. The administration time is 2 weeks.
The curative effect standard is as follows:
and (3) curing: the stool is smooth, once a day, moderate in hardness and good in diet, and accompanying symptoms disappear.
The method has the following advantages: defecate smoothly, with one or two days of solution each day, and sometimes dry.
And (4) invalidation: constipation was not significantly improved.
From the test results, it can be seen that: after taking the accurate medicated diet food product for preventing and treating senile functional constipation for two weeks, the total effective rate of constipation patients reaches 99.58%, and after taking the product for 2 weeks and stopping taking the product for 2 weeks, the total effective rate reaches 99.17%, and users do not feel uncomfortable.
The final form of the product of the invention can be various, including powder, granules, tablets, honeyed pills, soft extract, oral liquid, syrup and the like. In the preparation process, the drying mode can be spray drying, vacuum drying, freeze drying and the like; the granulation method can be dry granulation, wet granulation, one-step granulation and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements, etc. made by those skilled in the art within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The accurate medicated diet food therapy product for preventing and treating senile functional constipation is characterized by comprising the following substances in parts by mass: the composition comprises the following substances in parts by mass: 1-20 parts of moringa leaves, 1-20 parts of fructus cannabis, 1-15 parts of bunge cherry seeds, 1-15 parts of perilla seeds, 1-15 parts of semen cassiae, 1-15 parts of bitter apricot seeds, 1-10 parts of semen sesami nigrum, 1-15 parts of seville orange flowers, 0.5-3 parts of mannose oligomer and 1-5 parts of stachyose.
2. The accurate medicated diet food therapy product for preventing and treating senile functional constipation according to claim 1, which is characterized by comprising the following substances in parts by mass: 6-12 parts of moringa leaves, 6-12 parts of fructus cannabis, 3-9 parts of bunge cherry seeds, 3-9 parts of perilla seeds, 3-9 parts of semen cassiae, 3-9 parts of bitter apricot seeds, 3-8 parts of semen sesami nigrum, 3-9 parts of seville orange flowers, 0.8-1.5 parts of mannose oligomer and 2-4 parts of stachyose.
3. The accurate medicated diet food therapy product for preventing and treating senile functional constipation according to claim 1, which is characterized by comprising the following substances in parts by mass: 9 parts of moringa leaves, 9 parts of fructus cannabis, 6 parts of bunge cherry seeds, 6 parts of perilla seeds, 6 parts of cassia seeds, 6 parts of bitter apricot seeds, 5 parts of flax, 6 parts of seville orange flowers, 1.0 part of mannose oligomer and 3 parts of stachyose.
4. The accurate medicated diet food therapy product for preventing and treating senile functional constipation according to claim 1, wherein the accurate medicated diet food therapy product for preventing and treating senile functional constipation comprises liquid beverage, oral liquid, solid beverage, granules and tablets.
5. The preparation method of the accurate medicated diet product for preventing and treating senile functional constipation according to any one of claims 1 to 4, characterized in that the preparation method comprises the following steps:
s1, weighing traditional Chinese medicine decoction pieces such as moringa leaves, fructus cannabis, bunge cherry seed, perilla seed, cassia seed, bitter apricot seed, flax, seville orange flower and the like according to a proportion, wherein the fructus cannabis, the bunge cherry seed, the perilla seed and the cassia seed are simply crushed, packaged in a gauze bag, combined with other medicinal materials, added with 12 times of water for soaking for 30 minutes, heated and refluxed for extraction for 1 hour, filtered by 200 meshes, and added with 10 times of water for reflux extraction for 1 hour; mixing the filtrates, and concentrating under reduced pressure to obtain concentrated solution with density of about 1.08;
s2, adding purified water, stachyose and mannose oligomer into the concentrated solution to obtain the accurate medicated diet therapy product liquid beverage for preventing and treating senile functional constipation.
6. The method for preparing an accurate medicated diet therapy product for preventing and treating senile functional constipation according to claim 5, wherein an appropriate amount of maltodextrin is added to the concentrated solution obtained in step S1, and spray drying is carried out to obtain an extract; adding stachyose and oligomannose into the extract; adding flavoring and edible ingredients, mixing, packaging with a powder packaging machine, and packaging to obtain the accurate medicated diet dietetic product solid beverage for preventing and treating senile functional constipation.
7. The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation according to claim 6, wherein the accurate medicated diet food therapy product granules for preventing and treating senile functional constipation are obtained by adding stachyose and oligomannose into the spray-dried extract powder, adding seasonings and auxiliary materials, granulating, drying and subpackaging.
8. The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation according to claim 6, wherein the preparation method comprises the steps of adding stachyose and oligomannose into the spray-dried extract powder, adding one or more of maltodextrin, corn starch, wheat flour and protein powder, and performing dry granulation to obtain the accurate medicated diet food therapy product granules for preventing and treating senile functional constipation.
9. The preparation method of the accurate medicated diet dietary product for preventing and treating senile functional constipation according to claim 6, wherein the accurate medicated diet dietary product tablet for preventing and treating senile functional constipation is obtained by adding mannose oligomer and stachyose into the spray-dried extract powder, adding seasonings and auxiliary materials, granulating, drying and tabletting.
10. The preparation method of the accurate medicated diet food therapy product for preventing and treating senile functional constipation according to claim 6, characterized in that the accurate medicated diet food therapy product tablet for preventing and treating senile functional constipation is obtained by adding stachyose and oligomannose into spray-dried extract powder, and adding one or more of maltodextrin, corn starch, wheat flour and protein powder, and directly tabletting the powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110497923.2A CN113170848A (en) | 2021-05-08 | 2021-05-08 | Accurate medicated diet food therapy product for preventing and treating senile functional constipation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110497923.2A CN113170848A (en) | 2021-05-08 | 2021-05-08 | Accurate medicated diet food therapy product for preventing and treating senile functional constipation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113170848A true CN113170848A (en) | 2021-07-27 |
Family
ID=76928402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110497923.2A Withdrawn CN113170848A (en) | 2021-05-08 | 2021-05-08 | Accurate medicated diet food therapy product for preventing and treating senile functional constipation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113170848A (en) |
-
2021
- 2021-05-08 CN CN202110497923.2A patent/CN113170848A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101757279B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing Chinese eaglewood and preparation method thereof | |
| CN101757281B (en) | Traditional Chinese medicine composition for treating gastrointestinal disease and preparation method thereof | |
| CN112076170A (en) | Tablet with function of relaxing bowels | |
| CN101766780B (en) | Sandalwood-containing traditional Chinese medicine for treating gastrointestinal diseases and preparation method thereof | |
| CN103110884B (en) | Traditional Chinese medicine composition for treating chronic cholecystitis | |
| CN102430009B (en) | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN102430008B (en) | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN113170848A (en) | Accurate medicated diet food therapy product for preventing and treating senile functional constipation and preparation method thereof | |
| CN101757348B (en) | Traditional Chinese medicine composition for treating gastrointestinal disease and preparation method thereof | |
| CN101757278B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing costustoot and preparation method thereof | |
| CN101757288A (en) | Traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof | |
| CN101757289B (en) | Traditional Chinese medicine ointment for treating gastrointestinal diseases and preparation method thereof | |
| CN105853766A (en) | Purpose of traditional Chinese medicinal preparation for preparing medicine for treating primary hypertension | |
| CN101766732B (en) | Chinese medicine composite for treating gastrointestinal diseases and preparation method thereof | |
| CN1055232C (en) | Oral preparation capable of enriching yin and moistening intestines | |
| CN114632126B (en) | Traditional Chinese medicine combination medicine for treating functional constipation and preparation method and application thereof | |
| CN102430075B (en) | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN101757529B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing fructus amomi and preparation method thereof | |
| CN102416088B (en) | Chinese medicinal composition for treating gastrointestinal diseases and preparation method thereof | |
| CN101757291B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing Chinese angelica and preparation method thereof | |
| CN102430010B (en) | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN102416077B (en) | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN102416075B (en) | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN104189646A (en) | Traditional Chinese medicine for treating damp-heat type 2 diabetes mellitus and preparation method thereof | |
| CN101269129B (en) | Traditional Chinese medicine for treating hemorrhoid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210727 |
|
| WW01 | Invention patent application withdrawn after publication |