CN116209672A - Sars-cov-2抑制剂 - Google Patents

Sars-cov-2抑制剂 Download PDF

Info

Publication number
CN116209672A
CN116209672A CN202180049677.2A CN202180049677A CN116209672A CN 116209672 A CN116209672 A CN 116209672A CN 202180049677 A CN202180049677 A CN 202180049677A CN 116209672 A CN116209672 A CN 116209672A
Authority
CN
China
Prior art keywords
seq
amino acid
polypeptide
acid sequence
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180049677.2A
Other languages
English (en)
Chinese (zh)
Inventor
L·曹
B·考文垂
I·戈列什尼克
L·米勒
D·贝克
L·科佐多伊
J·鲍恩
L·卡特
J·B·凯斯
M·戴蒙德
N·埃德曼
A·亨特
M·C·杰维特
C·J·小五原
Y·朴
R·拉维钱德兰
L·J·斯图尔特
D·维斯勒
B·沃杰利
A·C·沃尔斯
K·吴
S·博伊肯
G·上田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NORTHWEST UNIVERSITY
University of Washington
Washington University in St Louis WUSTL
Original Assignee
NORTHWEST UNIVERSITY
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NORTHWEST UNIVERSITY, University of Washington, Washington University in St Louis WUSTL filed Critical NORTHWEST UNIVERSITY
Publication of CN116209672A publication Critical patent/CN116209672A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202180049677.2A 2020-07-14 2021-05-25 Sars-cov-2抑制剂 Pending CN116209672A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063051474P 2020-07-14 2020-07-14
US63/051,474 2020-07-14
US202063067593P 2020-08-19 2020-08-19
US63/067,593 2020-08-19
PCT/US2021/034069 WO2022015418A1 (en) 2020-07-14 2021-05-25 Sars-cov-2 inhibitors

Publications (1)

Publication Number Publication Date
CN116209672A true CN116209672A (zh) 2023-06-02

Family

ID=76808129

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180049677.2A Pending CN116209672A (zh) 2020-07-14 2021-05-25 Sars-cov-2抑制剂

Country Status (7)

Country Link
US (1) US20230250134A1 (cg-RX-API-DMAC7.html)
EP (1) EP4182027A1 (cg-RX-API-DMAC7.html)
JP (2) JP2023542453A (cg-RX-API-DMAC7.html)
KR (1) KR20230038485A (cg-RX-API-DMAC7.html)
CN (1) CN116209672A (cg-RX-API-DMAC7.html)
AU (1) AU2021308208A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022015418A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023282281A1 (ja) * 2021-07-07 2023-01-12 国立大学法人東京医科歯科大学 抗ウイルス活性を有するペプチド、当該ペプチドを含む抗ウイルス剤、当該抗ウイルス剤の製造方法
KR20240177843A (ko) * 2023-06-20 2024-12-30 주식회사 엔큐라젠 SARS-CoV-2스파이크 단백질에 특이적으로 결합하는 펩타이드 및 이의 용도
WO2025101453A1 (en) * 2023-11-07 2025-05-15 University Of Washington De novo design of potent minibinder antagonists of il-6r, gp130, and il1-r1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900033B2 (en) * 2001-06-04 2005-05-31 Human Genome Sciences, Inc. Methods and compositions for modulating ACE-2 activity

Also Published As

Publication number Publication date
JP2025170319A (ja) 2025-11-18
WO2022015418A1 (en) 2022-01-20
US20230250134A1 (en) 2023-08-10
KR20230038485A (ko) 2023-03-20
AU2021308208A1 (en) 2023-01-05
JP2023542453A (ja) 2023-10-10
EP4182027A1 (en) 2023-05-24

Similar Documents

Publication Publication Date Title
Saunders et al. Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
JP7566315B2 (ja) コンフォメーションが安定化されたｒｓｖ融合前ｆタンパク質
JP7094103B2 (ja) インフルエンザウイルスワクチンおよびその使用
CN105452270B (zh) 流行性感冒病毒疫苗及其用途
CN113597428B (zh) 重组流感抗原
CN106661091B (zh) 流行性感冒病毒疫苗及其用途
CN105073196B (zh) 呼吸道合胞病毒f蛋白表位
JP2025170319A (ja) Ｓａｒｓ－ｃｏｖ－２阻害剤
JP2018520159A (ja) Ｒｓｖに対するワクチン
TW202208404A (zh) 新穎錨蛋白重複結合蛋白質及其用途
WO2021170131A1 (zh) 可溶性ace2和融合蛋白，及其应用
US20210308250A1 (en) Zika virus immunogenic compositions
WO2021198999A1 (en) Epitope-based vaccines for treatment of coronavirus associated diseases
WO2023020623A1 (zh) 用于预防或治疗冠状病毒感染的融合蛋白、Spike蛋白纳米颗粒及其应用
Singh et al. A recent update on SARS-CoV-2 transmission and its variants: transmission, pathogenic mechanism, and treatment
CA3181996A1 (en) Sars-cov-2 inhibitors
US20240424087A1 (en) Multiepitope self-assembled nanoparticle vaccine platform (msn-vaccine platform) and uses there of
US10377798B2 (en) Recombinant respiratory syncytial virus G protein fragments
CN115925892A (zh) 一种抗新型冠状病毒的中和抗体d9及其应用
KR102812522B1 (ko) Covid-19 유전자 백신용 dna 단편 및 이를 포함한 유전자 백신용 조성물
JP2023546383A (ja) アネキシンａ５組成物及び方法
Case et al. Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice
CN114634579A (zh) 一种抗新冠病毒基因工程疫苗
CN115925893B (zh) 一种抗新型冠状病毒的中和抗体d7及其应用
RU2837537C1 (ru) Растворимый апф2, его слитый белок и способы их применения

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination