CN116195584A - Sterilization composition containing iprovalicarb and metiram - Google Patents

Sterilization composition containing iprovalicarb and metiram Download PDF

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Publication number
CN116195584A
CN116195584A CN202111440310.1A CN202111440310A CN116195584A CN 116195584 A CN116195584 A CN 116195584A CN 202111440310 A CN202111440310 A CN 202111440310A CN 116195584 A CN116195584 A CN 116195584A
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China
Prior art keywords
metiram
component
iprovalicarb
composition containing
powdery mildew
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Pending
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CN202111440310.1A
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Chinese (zh)
Inventor
罗昌炎
詹姆斯.T.布里斯托
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Jiangsu Rotam Chemical Co Ltd
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Jiangsu Rotam Chemical Co Ltd
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Priority to CN202111440310.1A priority Critical patent/CN116195584A/en
Publication of CN116195584A publication Critical patent/CN116195584A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/10—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with sulfur as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A01N47/14—Di-thio analogues thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention provides a sterilizing composition containing iprovalicarb and metiram, which comprises the component (A) of iprovalicarb and the component (B) of metiram as active ingredients, wherein the weight ratio of the component (A) to the component (B) is 5:1-1:250. the invention relates to an application of a sterilizing composition containing ipratropium and metiram in agriculture or horticulture for controlling diseases caused by plant pathogenic bacteria; and also to a method of preventing or controlling diseases on useful plants, especially fruits and vegetables.

Description

Sterilization composition containing iprovalicarb and metiram
Technical Field
The invention relates to a bactericidal composition containing iprovalicarb and metiram; the use of said fungicidal composition for controlling diseases caused by phytopathogens in agriculture or horticulture; and to a method of preventing or controlling diseases on useful plants, especially fruits and vegetables.
Background
Botrytis cinerea (melon gray mold, tomato gray mold, capsicum gray mold), powdery mildew (melon powdery mildew, strawberry powdery mildew, apple powdery mildew) becomes an increasingly serious problem in fruit and vegetable production, thereby resulting in considerable yield loss. Many of the commonly used fungicides are not suitable for controlling botrytis cinerea and powdery mildew-causing pathogenic fungi or their action against botrytis cinerea and powdery mildew-causing pathogenic fungi is not satisfactory.
Thus, there remains a need to develop new compounds and compositions possessing improvements in biological activity, spectrum of activity, crop tolerance, physicochemical properties, biodegradability, safety, synergistic interactions, and the like. It can show a faster onset of action and a longer lasting residual activity; and can achieve beneficial resistance management practices: reducing the number of applications and/or reducing the rate of application of the compounds and compositions required for effective control of plant pathogens, reducing environmental impact and reducing operator exposure.
Disclosure of Invention
The present invention aims to provide a bactericidal composition which aims at overcoming the defects.
The present invention has completed the present invention by combining component (a) ipratropium and component (B) mancozeb, and obtaining unexpected excellent bactericidal effects against pathogenic fungi causing fruit rot, flower and seed diseases, such as Botrytis species (Botrytis cinerea), and against pathogenic fungi causing powdery mildew, such as erysiphe necator species (Blumeria species) (such as erysiphe gramineae (Blumeria graminis)), erysiphe graminis species (Podosphaera species) (such as erysiphe graminis (podosphaeraleuca)), eryngium species (Sphaerotheca species) (such as erysiphe graminis (Sphaerotheca fuliginea)), and crocus species (Uncinula species) (such as Uncinula necator)), compared with the case of using each compound alone.
The invention provides a novel sterilizing composition containing iprovalicarb and metiram, which comprises the component (A) of iprovalicarb and the component (B) of metiram as active ingredients. Typically the weight ratio of component (a) to component (B) is from 1000:1-1:1000, preferably 500:1-1:1000, more preferably 50:1-1:500, more preferably 10:1-1:500, more preferably 5:1-1:250, more preferably 1:1-1:128. More preferably 1:1-1:64, more preferably 1:1-1:32, particularly preferably 1:1-1:16.
the sterilizing composition containing the ipratropium and the metiram also comprises at least one agriculturally suitable auxiliary agent.
The bactericidal composition containing the ipratropium and the metiram can be used for preventing or controlling plant diseases caused by Oomycetes (Oomycetes), ascomycetes (Ascomycetes), basidiomycetes (Basidiomycetes) or semi-known fungus (Deuteromycetes) plant pathogenic fungi.
The sterilizing composition containing the iprovalicarb and the metiram is used for preventing or controlling powdery mildew of cucumber, powdery mildew of wheat, powdery mildew of strawberry, powdery mildew of apple, powdery mildew of rose, gray mold of tomato, gray mold of capsicum, gray mold of cucumber, gray mold of cloud bean, stem rot of cloud bean, glume blight of wheat, sheath blight of rice, rice blast, late blight of tomato and downy mildew of cucumber.
A method for preventing or controlling phytopathogenic fungi, said fungicidal composition comprising iprovalicarb and metiram is applied to seeds, to seedlings, plants, plant parts, fruits, harvested products and/or to the soil in which the plants are grown.
A method for preventing or controlling soil-borne diseases comprises the step of applying the sterilizing composition containing the iprovalicarb and the metiram to soil in a manner of dripping, drip irrigation, soil injection and soil infiltration.
The fungicidal compositions of the present invention have improved activity against plant pathogenic bacteria (synergy) at a reduced total amount of active compound applied, in terms of reducing the application rate and improving the activity profile of known compounds.
The sterilizing composition containing ipratropium and metiram of the present invention can be used to control plant diseases caused by a broad spectrum of fungal plant pathogens in the class Oomycetes (oomyces), ascomycetes (Ascomycetes), basidiomycetes (basidiomyces) or deuteromycetes (deuteromyceta).
The compositions of the present invention are effective in controlling a broad spectrum of plant diseases such as foliar pathogens in ornamental plants, turf, vegetables, fields, cereals, and fruit crops.
These pathogens may include:
fungi imperfecti, including Botrytis, such as various Botrytis cinerea, such as Botrytis cinerea, citrus Botrytis cinerea, cucumber Botrytis cinerea, tomato Botrytis cinerea, strawberry Botrytis cinerea, eggplant Botrytis cinerea, cloud bean Botrytis cinerea, pea Botrytis cinerea, peanut Botrytis cinerea, pepper Botrytis cinerea, sweet pepper Botrytis cinerea, lettuce Botrytis cinerea, onion Botrytis cinerea, carnation Botrytis rosea Botrytis cinerea, pansy Botrytis cinerea, or sunflower Botrytis cinerea; septoria, such as, for example, septoria nodorum (Septoria nodorum), septoria tritici (Septoria tritici); pyricularia, such as Pyricularia oryzae (Pyricularia oryzae); cercospora species, such as cercospora betana (Cercospora beticola), or cercospora kaki (Cercospora kakivola); anthracis, e.g., cucumber anthracis (Colletotrichum orbiculare); alternaria, such as Alternaria mali (Alternaria alternate pathotype), alternaria pyriformis (Alternaria alternata pathotype), alternaria solani (Alternaria solani), alternaria solani (Alternaria brassicae), alternaria brassicae (Alternaria brassicola), alternaria alliacea (Alternaria porri); pseudomonas, such as Vitis vinifera (Pseudocercospora vitis); cladosporium, such as Botrytis cinerea (Cladosporium carpophilum); phomopsis, e.g., phomopsis nectar spot sp.); alternaria species, such as Eben anthracis (Gloeosporium kaki); brown spore genus such as, for example, brown mold species (Fulvia fulva); and corynespora species, such as cucumber brown rot fungi (Corynespora cassiicola);
ascomycetes, including powdery mildew, such as powdery mildew wheat (Erysiphe graminis); monascus, e.g., powdery mildew cucumber (Sphaerotheca fuliginea), or powdery mildew strawberry (Sphaerotheca humuli); uncaria genus, such as powdery mildew (Uncinula necator); the genus Leptospira, such as Alternaria mali (Podosphaera leucotricha); globus, for example, photinia apple (Mycosphaerella pomi), sigatoka (Mycosphaerella musicola), persimmon leaf spot (Mycosphaerella nawae), or strawberry leaf spot (Mycosphaerella fragariae); the genus cladosporium, such as cladosporium apple (Venturia inaequalis), or cladosporium peach (Venturia nashicola); nuclear cavity genus, such as barley reticulate bacteria (Pyrenophora teres), or barley stripe bacteria (Pyrenophora graminea); sclerotinia species, such as various sclerotinia sclerotiorum (Sclerotinia Sclerotiorum) such as Rhizoctonia solani, rhizoctonia cerealis, sclerotinia bergii, sclerotinia glabra, or Rhizoctonia cepacia, rhizoctonia cerealis (Sclerotinia borealis), rhizoctonia solani (Sclerotinia minor), or Sclerotinia medicata and Rhizoctonia cerealis (Sclerotinia trifoliorum); xylosporium, such as brown spot rice bacteria (Cochliobolus miyabeanus); the genus Microbiennis, such as, for example, the genus Rhizoctonia cerealis (Didymella bryoniae); gibberella, such as fusarium oxysporum (Gibberella zeae); elsinoe, such as Botrytis cinerea (Elsinoe ampelina), or citrus scab bacteria (Elsinoe fawcettii); the genus chaetomium, such as, for example, the species black spot citrus (Diaporthe citri); the genus Sclerotinia, such as, for example, sclerotinia mali (Monilinia mali), or Sclerotinia persicae (Monilinia fructicola); and Convolvulus, such as Botrytis cinerea (Glomerella cingulata).
Oomycetes, including phytophthora species, such as potato or tomato late blight bacteria (Phytophthora infestants); downy mildew, such as cucumber downy mildew (Pseudoperonospora cubensis); downy mildew (Plasmopara), such as Botrytis cinerea (Plasmopara viticola); and Pythium species, such as Rhizoctonia solani (Phthium graminicola), or Rhizoctonia cerealis (Pythum iwayamai).
Basidiomycetes, including rhizoctonia, such as banded sclerotial blight (Rhizoctonia solani); ustilago, such as Ustilago (Ustilago nuda); puccinia, for example, puccinia avenae (Puccinia coronata), leptoradix Tritici (Puccinia recondita), or Leptoradix Tritici (Puccinia striiformis); and sclerotinia species, such as wheat or barley sclerotinia snow rot (Typhula incarnata, typhula ishikariensisis).
The composition containing the ipratropium and the metiram can control various harmful fungi and further can prevent or control various diseases. In particular, the composition of the present invention is effective in controlling various diseases in agricultural and horticultural fields. For example, gray mold of various crops such as grape gray mold, citrus gray mold, cucumber gray mold, tomato gray mold, strawberry gray mold, eggplant gray mold, cloud bean gray mold, red bean gray mold, pea gray mold, peanut gray mold, pepper gray mold, sweet pepper gray mold, lettuce gray mold, onion gray mold, carnation gray mold, rose gray mold, pansy gray mold, sunflower gray mold, onion gray mold; powdery mildew, scab, leaf rust, stripe rust, reticulate pattern, stripe, snow mold, snow blight, loose smut, banded sclerotial blight, leaf spot or glume blight of grain; powdery mildew, scab, cladosporium cucumerinum or scab of apple; scab or black spot of pear; brown rot, scab or brown rot of peach; anthracnose, leaf spot and powdery mildew of grape; anthracnose, powdery mildew, gummy stem blight, brown spot or powdery mildew of cucurbits; tomato early blight, leaf mold or late blight; leaf spot of bananas; brown spot of beet; gummy stem blight of peas; various black spot germs of cruciferous vegetables; late blight or early blight of potato; powdery mildew or leaf spot of strawberry; blast, brown spot, banded sclerotial blight or damping-off of rice.
The plants which can be treated by the sterilizing composition containing the ipratropium and the metiram comprise the following components: primary crop plants such as cruciferae (brassica oleracea.) (e.g., white cabbage, red cabbage, broccoli, cauliflower, brussels sprouts, green vegetables, corm cabbage, radish, canola, mustard, horseradish, and cress), butterfly (Fabacae sp.) (e.g., beans, peanuts), solanaceae (Solanaceae sp.) (e.g., potatoes), chenopodiaceae (Chenopodiaceae sp.) (e.g., sugar beet, fodder beet), rutaceae (e.g., lemon, orange, and grapefruit), cotton, flax, grape vine, fruit, vegetables, tea deer sub-family (ribeidae sp.) (e.g., cucumber), cucurbitaceae (cuurbitaceae sp.) (e.g., corn, turf, grains such as wheat, rye, rice, barley, oat, millet, and triticale), compositae (Asteraceae sp.) (e.g., sunflower), juglandace (juglandaceae sp.) (e.g., betulinae sp.)), anacardiaceae (Anacardiaceae sp.) (Fagaceae sp.) (e.g., cucumber), moraceae sp.) (e.g., oleaceae sp.) (e.c acid sp.) (c acid sp.)), oleaceae (Anacardiaceae sp.) (acteraceae sp.)), camphoraceae (Lauraceae (anaceae sp.) (Anacardiaceae sp.) (e.g., banana tree and plantation), alize.g., rubiaceae (e.g., coffee), lithology (e.g., beautyceae), liliaceae (e.g., more than one sp.)), liliaceae (liliaceae sp.) (e.g., liliaceae sp.)), liliaceae (liliaceae sp.) (anaceae sp.)), liliaceae sp.) (anaceae sp.) (e., alliaceae (Alliaceae sp.) (e.g., leek, onion); useful plants and ornamental plants for use in gardens and forest areas.
The sterilizing composition containing the ipratropium and the metiram can treat all plants, plant parts and plant propagation materials.
"plant" refers to all plants and plant populations such as desirable and undesirable wild plants, cultivated plants and plant varieties (whether protected by plant varieties or plant growing rights). The cultivated plants and plant varieties may be plants obtained by conventional propagation and cultivation methods, which may be supplemented or supplemented with one or more biotechnological methods, for example using doubled haploids, protoplast fusion, random and directed mutations, molecular or genetic markers, or using bioengineering and genetic engineering methods.
"plant part" refers to all above and below ground parts and organs of a plant, such as shoots, leaves, flowers and roots, such as leaves, needles, stems, branches, flowers, fruit bodies, fruits and seeds, and roots, bulbs and rhizomes.
"plant propagation material" is understood to mean all plant parts, such as seeds, which have reproductive capacity and which can be used for propagating the latter, as well as plant materials such as cuttings or tubers (e.g. potatoes). Thus, plant parts as used herein include plant propagation material. Mention may be made, for example, of seeds, roots, fruits, tubers, bulbs, rhizomes and plant parts. Germinated plants to be germinated from soil or suppressed after emergence of seedlings, and effective plants. Young plants may be protected by impregnation, either entirely or partially, prior to implantation. The component (A) and the component (B) constituting the fungicidal composition of the present invention may be mixed with various adjuvants to prepare various forms of preparations for use. The components (A) and (B) of the present invention may be present in suspended, emulsified or dissolved form, for example powders, granules, aqueous suspensions, oily suspensions, aqueous emulsions, pastes, aerosols, emulsions. All the formulations used in the field in general can be prepared as long as they are suitable for the purpose of the present invention.
As the auxiliary agent used in the formulation, carriers, surfactants, and the like may be included. The choice of adjuvant is related to the intended mode of application and/or physical properties of the bactericidal composition of the invention.
The carrier generally improves the applicability of the compound to, for example, plants, plant parts or seeds, aids the arrival of the active ingredient at the locus to be treated and allows for storage, transport or treatment of the active ingredient for easier application. Surfactants are commonly used to emulsify, disperse, spread, or/and wet crops.
The carrier is typically an inert solid or liquid. The amount of carrier is generally in the range of 1 to 95 wt%, preferably 10 to 95 wt%, more preferably 20 to 95 wt%, based on the weight of the bactericidal composition.
Examples of suitable solid carriers include, but are not limited to, inorganic substances such as bentonite, montmorillonite, kaolinite, diatomaceous earth, clay, talc, clay, gypsum, calcium carbonate, amorphous silica, ammonium sulfate, and the like; plant organic substances such as soybean meal, wood flour, sawdust, wheat flour, lactose, sucrose, glucose, etc.;
examples of suitable liquid carriers include, but are not limited to, water, organic solvents, and combinations thereof. Examples of suitable solvents include polar and non-polar organic chemical liquids such as water, petroleum ether, vegetable oils, methyl ethyl ketone, cyclohexanone, amyl acetate, 2-butanone, butylene carbonate, cyclohexane, cyclohexanol, alkyl acetate, diacetone alcohol, diethanolamine, diethylene glycol rosin acid, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N-dimethylformamide, dimethyl sulfoxide, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, dipropylene glycol, alkyl pyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 2-heptanone, ethyl lactate, ethylene glycol butyl ether, ethylene glycol methyl ether, gamma-butyrolactone, glycerol acetate, glycerol diacetate, glycerol triacetate, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl caprylate, methyl oleate, N-hexane, N-octylamine, stearic acid, octylamine acetate, oleic acid, oleylamine, polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol methyl ether, triethyl phosphate, triethylene glycol, paraffin, mineral oil, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, ethanol, isopropanol, and higher molecular weight alcohols such as amyl alcohol, tetrahydrofuranol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol, and the like.
The sterilizing composition comprising ipratropium and metiram may further comprise one or more surface active agents, which are commonly used in formulating compositions (e.g. agrochemical compositions). The amount of surfactant is typically from 0% to 80% by weight of the composition. The surfactant comprises a nonionic surfactant and an anionic surfactant.
Nonionic surfactants such as polyoxyethylene castor oil, polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene dialkylphenyl ethers, polyoxyethylene polyoxypropylene block polymers, alkyl polyoxyethylene polyoxypropylene block polymer ethers, alkylphenyl polyoxyethylene polyoxypropylene block polymer ethers, polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, polyoxyethylene diphenyl ethers, polyoxyethylene benzyl phenyl ethers, and sorbitol fatty acid esters, polyoxyethylene sorbitol fatty acid esters, sucrose fatty acid esters, polyoxyethylene fatty acid diesters, and the like.
Anionic surfactants such as naphthalene sulfonate, naphthalene disulfonate, alkyl diphenyl ether disulfonate, lignin sulfonate, polyoxyethylene alkylphenyl ether sulfonate, polyoxyethylene alkyl ether sulfosuccinic half ester, fatty acid salt, polyoxyethylene alkyl ether phosphate, alkyl sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkylphenyl ether sulfate, polyoxyethylene benzyl phenyl ether sulfate, polyoxyethylene styrylphenyl ether sulfate, polyoxyethylene polyoxypropylene block polymer sulfate, alkane sulfonate, dialkyl sulfosuccinic sulfonate, alkylbenzenesulfonate, polyoxyethylene phenyl ether phosphate, polyoxyethylene dialkyl phenyl ether phosphate, polyoxyethylene benzyl phenyl ether phosphate, polyoxyethylene styrylated phenyl ether phosphate, polyoxyethylene polyoxypropylene block polymer phosphate, alkyl phosphate, sodium tripolyphosphate, and the like.
In addition, various commonly used auxiliary agents such as binders, disintegrants, stabilizers, pH adjusters, thickeners, antifoaming agents, antifreezes and the like may be used.
Binders such as polyvinyl alcohol, acacia, bentonite, etc.;
disintegrants, for example, CMC sodium or croscarmellose sodium;
stabilizers such as hindered phenol-based antioxidants, or benzotriazole-based or hindered amine-based UV absorbers;
pH adjusters, such as citric acid, phosphoric acid, acetic acid or sodium hydroxide;
fungicides, antifungal and preservative agents for industrial purposes such as 1, 2-benzothiazolin-3-one and the like;
a thickener; for example, xanthan gum, guar gum, CMC sodium, acacia, polyvinyl alcohol, montmorillonite, or the like;
defoaming agents, for example, silicone-based compounds;
antifreezing agents, such as propylene glycol, e.g., propylene glycol or ethylene glycol, and the like.
The bactericidal composition containing the ipratropium and the metiram of the present invention can be provided to the end user as a ready-to-use formulation, i.e. the composition can be applied directly to the plants or seeds by means of a suitable device such as a spraying device or a powdering device. The composition may also be provided to the end user in the form of a concentrate which must be diluted before use, preferably with water.
In addition, the composition containing iprovalicarb and metiram of the present invention is also effective in preventing or controlling soil diseases caused by plant pathogens such as fusarium, pythium, rhizoctonia, verticillium and plasmodiophora.
In addition, the composition containing the ipratropium and the metiram of the present invention has excellent penetration and migration properties, and when the pesticide containing the composition of the present invention is applied to the soil, it is possible to control harmful fungi on roots and leaves while controlling harmful fungi in the soil.
Methods of applying agents to the soil, such as diluting a liquid agent in water or directly to the roots of plants without dilution; spreading the granule to root of plant; or spraying the powder, the water dispersible granule and the like into soil before sowing and integrally mixing with the soil, and spraying the powder, the water dispersible granule and the like into planting holes and planting furrows before sowing or before planting plants, and then sowing.
Soil application methods include methods of applying the pesticide compound directly or indirectly to the soil and/or the ground, such as drip or drip irrigation (onto the soil) or other methods of soil injection, infiltration of the soil. Other known soil application methods are in-furrow and T-band application.
The sterilizing composition containing the ipratropium and the metiram of the present invention can be used for protecting seeds, germinated seeds, emerging seedlings, plants, plant parts, fruits, harvested products and/or soil where plants are grown from attack by phytopathogenic fungi.
The invention also relates to a method for preventing or controlling phytopathogenic fungi, comprising applying the fungicidal composition comprising iprovalicarb and metiram according to the invention to seeds, germinated seeds, emerging seedlings, plants, plant parts, fruits, harvested products and/or the soil in which the plants are grown.
The present invention also relates to a method for preventing or controlling phytopathogenic fungi, which comprises applying seed, germinated seed, emerging seedlings, plants, plant parts, fruits, harvested products and/or soil where plants are grown in an effective and plant compatible amount by seed treatment, foliar application, stem application, soaking, instillation, casting, spraying, atomizing, dusting, scattering or fuming, etc. of the fungicidal composition comprising iprovalicarb and metiram according to the invention.
"preventing or controlling" includes protective, therapeutic and eradicative treatments of phytopathogenic fungi.
The application dose of the composition containing the ipratropium and the metiram of the present invention may vary depending on weather conditions, the type of formulation, the crop to be treated, the application season, the application site, the type or germination status of harmful fungi, and the type or outbreak degree of disease.
For stem and leaf treatment: the amount of active ingredient is 1-5,000g/ha, preferably 10-1,000g/ha;
for soil treatment, the amount of active ingredient is from 10 to 10,000g/ha, preferably from 50 to 2,000g/ha.
In the sterilizing composition containing the iprovalicarb and the metiram, the component (A) and the component (B) can be combined/jointly applied, and the component (A) and the component (B) can be applied separately, sequentially or simultaneously. Preferably, the component (a) and the component (B) are combined in the form of a composition comprising component (a) and component (B).
The sterilizing composition comprising ipratropium and metiram of the present invention is accomplished in conventional manner in an agronomically effective and substantially non-phytotoxic application amount, for example by watering, spraying, atomizing, broadcasting, dusting, foaming, spreading, etc. It may also be applied by ultra low volume methods, drip irrigation systems or saturation. The sterilizing composition containing the iprovalicarb and the metiram of the invention can also be applied in furrows or injected into the soil.
The amount of the sterilizing composition comprising ipratropium and metiram of the present invention applied to plants, plant parts, fruits, seeds or soil must be effective and plant compatible.
By "effective and phytocompatible amount" is meant an amount that is agronomically effective and does not cause any significant phytotoxic symptoms in the crop. This will depend on various factors such as the object of treatment (plant, plant part, fruit, seed or soil), the type of treatment (dusting, spraying, dressing), the purpose of the treatment (therapeutic and protective), the type of phytopathogenic fungi or bacteria, the stage of development of the phytopathogenic fungi or bacteria, the sensitivity of the phytopathogenic fungi or bacteria, the stage of crop growth and the environmental conditions.
In order to provide a use effect, the sterilizing composition containing the iprovalicarb and the metiram can be processed into various formulations with fertilizers or applied together with or mixed with the fertilizers. Suitable fertilizers include one or more major elements of nitrogen, phosphorus, potassium, etc., or one or more trace elements of copper, iron, manganese, zinc, boron, calcium, magnesium, sulfur, etc., or one or two mixtures of fertilizers including humic acid, amino acid, etc.
The bactericidal composition containing the iprovalicarb and the metiram has synergistic effect when the activity of two or more compounds exceeds the activity of the compounds when the compounds are singly used. The bactericidal composition containing ipratropium and metiram of the present invention has improved activity (synergistic) against plant pathogenic bacteria at a reduced total amount of active compound applied in terms of reducing the application rate and improving the activity profile of known compounds.
Detailed Description
Biological test case
There is a synergistic effect when the effect of the active compound combination exceeds the sum of the effects of each active compound when administered alone. The expected effect of a particular combination of two active compounds can be calculated using the so-called "Colby formula" (see s.r. Colby, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations" days 1967,15, 20-22) as follows:
Figure 884232DEST_PATH_IMAGE001
x is the control effect when component (A) is used in an amount of m g/ha or at a concentration of m ppm;
y is the control effect when component (B) is used in an amount of n g/ha or at a concentration of n ppm;
e is the theoretical control of the components (A) and (B) when used in amounts of m and n g/ha or at concentrations of m and n ppm, the composition having a synergistic effect if the actual observed control is greater than the theoretical control.
The following biological test examples illustrate the invention. However, the present invention is not limited to these examples.
Test 1: powdery mildew of cucumber
The raw materials of the component (A) and the component (B) are respectively dissolved by acetone to prepare mother solution of a single agent, and then diluted to the required concentration by aqueous solution containing 0.1% of Tween-80.
The bactericidal activity of the agent on powdery mildew of cucumber is determined by a living potting method. And selecting potted cucumber seedlings with consistent growth vigor in the two leaf periods for standby.
Washing fresh spores on leaf of disease-causing cucumber with 0.1% Tween-80 aqueous solution, and filtering with double-layer gauze to give 5×10 concentration 5 ~6×10 5 individual/mL spore suspension was ready for use.
And uniformly spraying stems and leaves of the potted seedlings to be tested until the leaves are fully wetted, and naturally air-drying the liquid medicine for later use. After 24h inoculation. 4 replicates, 10 pots each, 1 seedling per pot. And a treatment without a drug (containing an organic solvent and an emulsifier) was used as a blank.
The sporangia suspension was evenly sprayed onto cucumber leaves with an inoculation sprayer. After cucumber seedlings are inoculated, the cucumber seedlings are transferred into a greenhouse with the illumination intensity of more than 2000lx for normal culture. Investigation was performed after 7 days. The disease conditions of each treatment were examined in a grading manner. The grading method comprises the following steps:
level 0: no disease;
stage 1: the area of the disease spots accounts for less than 5% of the area of the whole leaf;
3 stages: the area of the disease spots accounts for 6% -10% of the area of the whole leaf;
5 stages: the area of the disease spots accounts for 11% -20% of the area of the whole leaf;
7 stages: the area of the disease spots accounts for 21% -40% of the area of the whole leaf;
stage 9: the area of the disease spots accounts for more than 40% of the area of the whole leaf.
The disease index and the control effect are calculated according to the following formula.
Figure 836008DEST_PATH_IMAGE002
%
Figure 839736DEST_PATH_IMAGE003
100％
TABLE 1 control of powdery mildew of cucumber by the inventive composition
Figure 484344DEST_PATH_IMAGE004
Table 1 clearly shows that the actual control effect of the bactericidal composition of the invention on powdery mildew of cucumber is higher than that calculated by the Colby formula, i.e. a synergistic effect exists.
Test 2: powdery mildew of wheat
The raw materials of the component (A) and the component (B) are respectively dissolved by acetone to prepare mother solution of a single agent, and then diluted to the required concentration by aqueous solution containing 0.1% of Tween-80.
The bactericidal activity of the agent on wheat powdery mildew is determined by a living potting method. 20 wheat seeds are sowed in each pot, 10 wheat seeds are selected after emergence of seedlings, and the seedlings grow to 1 leaf and 1 heart period for standby.
And uniformly spraying stems and leaves of the potted seedlings to be tested until the leaves are fully wetted, and naturally air-drying the liquid medicine for later use. After 24h inoculation. For each treatment 1 pot, 4 replicates were performed. And a treatment without a drug (containing an organic solvent and an emulsifier) was used as a blank.
And uniformly shaking out the fresh spores of powdery mildew generated in 24 hours on the diseased wheat leaves, and inoculating the spores on the treated wheat seedlings.
After inoculation, the wheat seedlings are placed in a greenhouse with the illumination intensity of more than 2000lx for low-humidity culture（15-26 O C) And grading and investigation according to the blank disease condition after 7 d.
Grading standard:
level 0: no disease;
stage 1: the area of the disease spots accounts for less than 5% of the area of the whole leaf;
3 stages: the area of the disease spots accounts for 6% -10% of the area of the whole leaf;
5 stages: the area of the disease spots accounts for 11% -25% of the area of the whole leaf;
7 stages: the area of the disease spots accounts for 26% -50% of the area of the whole leaf;
stage 9: the area of the disease spots accounts for more than 50% of the area of the whole leaf.
The disease index and the control effect are calculated according to the following formula. .
Disease of the patient
Figure 209242DEST_PATH_IMAGE005
%
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%
TABLE 2 control of powdery mildew of wheat by the inventive composition
Figure 760626DEST_PATH_IMAGE007
Table 2 clearly shows that the actual control effect of the bactericidal composition of the invention on wheat powdery mildew is higher than that calculated by the Colby formula, i.e. a synergistic effect exists.
Test 3: gray mold of cucumber
The raw materials of the component (A) and the component (B) are respectively dissolved by acetone to prepare mother solution of a single agent, and then diluted to the required concentration by aqueous solution containing 0.1% of Tween-80.
The bactericidal activity of the agent on the gray mold of cucumber is determined by adopting a living potting method. And selecting potted cucumber seedlings with consistent growth vigor in the two leaf periods for standby.
Adding culture solution into a culture dish with spore, gently scraping surface spore, filtering with 4 layers of gauze, and making into 5×10 concentration 6 ~6×10 6 individual/mL spore suspension was ready for use.
And uniformly spraying stems and leaves of the potted seedlings to be tested until the leaves are fully wetted, and naturally air-drying the liquid medicine for later use. After 24h inoculation. 4 replicates, 10 pots each, 1 seedling per pot. And a treatment without a drug (containing an organic solvent and an emulsifier) was used as a blank.
The spore suspension was uniformly sprayed onto cucumber leaves with an inoculation sprayer. Inoculating cucumber seedling, transferring into a humidity-preserving box, and culturing without illumination (relative humidity>85% at 18-20 o C) A. The invention relates to a method for producing a fibre-reinforced plastic composite And (5) investigation after 3 d. The disease conditions of each treatment were examined in a grading manner.
The grading method comprises the following steps:
level 0: no disease spots;
stage 1:3 disease spots are arranged on a single leaf;
3 stages: 4-6 disease spots are arranged on a single leaf;
5 stages: 7-10 disease spots are arranged on a single leaf;
7 stages: the single leaf has 11-20 disease spots, and part of the single leaf is densely packed into a sheet;
stage 9: the single leaf has more than one quarter of densely-occupied disease spots.
The disease index and the control effect are calculated according to the following formula.
Figure 576135DEST_PATH_IMAGE008
%
Figure 785400DEST_PATH_IMAGE009
%
TABLE 3 control of cucumber gray mold by the inventive compositions
Figure 344557DEST_PATH_IMAGE010
Table 3 clearly shows that the actual control effect of the bactericidal composition of the invention on cucumber gray mold is higher than that calculated by the Colby formula, namely, a synergistic effect exists.
Test 4: tomato late blight
The raw materials of the component (A) and the component (B) are respectively dissolved by acetone to prepare mother solution of a single agent, and then diluted to the required concentration by aqueous solution containing 0.1% of Tween-80.
The bactericidal activity of the agent against tomato late blight was determined by a living potting method. Tomato seedlings are planted in a plastic basin, and the substrate is a vegetable planting substrate. Culturing in pot to 2-4 pieces of true leaf stage for use.
Culturing pathogenic bacteria for test on a proper culture medium, and after sporangia is generated, 4 o Washing sporangium with distilled water, filtering with double gauze, and making into sporangium suspension (2×10) 5~ 3×10 5 personal/mL), placed in 8-10 o C, at low temperature, performing dark treatment for 0.5-3h to release zoospores.
And uniformly spraying stems and leaves of the potted seedlings to be tested. The front and back sides of the leaves to be inoculated are sprayed with each treatment agent until the leaves are wet, and then inoculated after 24 hours. For each treatment of 3 pots, 4 replicates were performed. And a treatment without a drug (containing an organic solvent and an emulsifier) was used as a blank.
The sporangium suspension was evenly sprayed onto the back of tomato leaves with an inoculation sprayer. The tomato seedlings are alternately irradiated with light/dark continuously for 12 hours each day after inoculation, the irradiation intensity is 10000Lux, and the temperature is 18 O C -20 O C, maintaining a water film on the leaf surface within 24 hours after inoculation, and culturing for 5 days under the condition that the relative humidity is more than 90%.
And when the leaf rate of the blank control reaches more than 50%, the disease conditions of all treatments are investigated in a grading way. At least 30 leaves per treatment were investigated;
the grading method comprises the following steps:
level 0: no disease spots;
stage 1: the area of the disease spots accounts for less than 10% of the whole leaf area;
3 stages: the area of the lesion accounts for 10% -25% of the whole leaf area;
5 stages: the area of the lesion accounts for 25% -50% of the whole leaf area;
7 stages: the area of the disease spots accounts for more than 50% of the whole leaf area;
stage 9: whole leaves withered.
The disease index and the control effect are calculated according to the following formula.
Figure 260560DEST_PATH_IMAGE011
Figure 981392DEST_PATH_IMAGE012
TABLE 4 control of tomato late blight by the compositions of the invention
Figure 412373DEST_PATH_IMAGE013
Table 4 clearly shows that the actual control effect of the bactericidal composition of the invention on tomato late blight is higher than that calculated by the Colby formula, i.e. a synergistic effect exists.
The following describes examples of the formulation of the present invention. However, the formulation amount, the ratio, the formulation, and the like are not limited to the following examples.
Formulation example 1
5 parts by weight of component (A)
50 parts by weight of component (B)
Clay 40 weight portions
Sodium lignin sulfonate 5 weight portions
The components are uniformly mixed to obtain wettable powder.
Formulation example 2
35 parts by weight of component (A)
35 parts by weight of component (B)
Bentonite 10 parts by weight
Sodium lignin sulfonate 7 weight portions
13 parts by weight of kaolin
Adding a proper amount of water required by granulation into the components, mixing and granulating to obtain the water dispersible granule.
Formulation example 3
40 parts by weight of component (A)
8 parts by weight of component (B)
6 parts by weight of nonylphenol polyethylene glycol ether (15 mol of ethylene oxide)
Sodium lignin sulfonate 0.2 weight portions
Carboxymethyl cellulose 1 weight part
0.2 part by weight of siloxane
44.6 parts by weight of water
The above components were uniformly mixed and ground to obtain a water-based suspension concentrate.

Claims (10)

1. The sterilizing composition containing the iprovalicarb and the metiram is characterized by comprising the iprovalicarb and the metiram serving as active ingredients, wherein the weight ratio of the component (A) to the component (B) is 5:1-1:250.
2. the sterilizing composition containing iprovalicarb and metiram according to claim 1, wherein the weight ratio of component (a) to component (B) is 1:1-1:128.
3. the sterilizing composition containing iprovalicarb and metiram according to claim 1, wherein the weight ratio of component (a) to component (B) is 1:1-1:64.
4. the sterilizing composition containing iprovalicarb and metiram according to claim 1, wherein the weight ratio of component (a) to component (B) is 1:1-1:32.
5. the sterilizing composition containing iprovalicarb and metiram according to claim 1, wherein the weight ratio of component (a) to component (B) is 1:1-1:16.
6. the sterilizing composition containing iprovalicarb and metiram according to claim 1, characterized in that said sterilizing composition further comprises at least one agriculturally suitable adjuvant.
7. Use of a bactericidal composition containing ipratropium and metiram according to claim 1 for preventing or controlling plant diseases caused by phytopathogenic fungi of the class Oomycetes (Oomycetes), ascomycetes (Ascomycetes), basidiomycetes (Basidiomycetes) or semi-known mycota (deuteromyceta).
8. Use of the sterilizing composition containing iprovalicarb and metiram according to claim 1 for preventing or controlling powdery mildew of cucumber, powdery mildew of wheat, powdery mildew of strawberry, powdery mildew of apple, powdery mildew of rose, gray mold of tomato, gray mold of capsicum, gray mold of cucumber, gray mold of cloud bean, stalk rot of cloud bean, glume blight of wheat, sheath blight of rice, rice blast, late blight of tomato, and downy mildew of cucumber.
9. A method for preventing or controlling phytopathogenic fungi, characterized in that the fungicidal composition comprising iprovalicarb and metiram according to claim 1 is applied to seeds, to seedlings, to plants, to plant parts, to fruits, to harvested products and/or to the soil in which the plants are grown.
10. A method for preventing or controlling soil-borne diseases, characterized in that the sterilizing composition comprising iprovalicarb and metiram according to claim 1 is applied to the soil by means of drip application, drip irrigation, soil injection, infiltration of the soil.
CN202111440310.1A 2021-11-30 2021-11-30 Sterilization composition containing iprovalicarb and metiram Pending CN116195584A (en)

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