CN112056316A - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN112056316A CN112056316A CN202011083067.8A CN202011083067A CN112056316A CN 112056316 A CN112056316 A CN 112056316A CN 202011083067 A CN202011083067 A CN 202011083067A CN 112056316 A CN112056316 A CN 112056316A
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- epoxiconazole
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- picarbitrazox
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The invention provides a bactericidal composition which comprises active ingredients of Picarbitrazox and epoxiconazole, wherein the weight ratio of Picarbitrazox to epoxiconazole is 50:1-1: 50. According to the invention, the Picarbitrazox and the epoxiconazole are subjected to binary compounding, so that the composition has an obvious gain effect on preventing and treating diseases caused by fungi and bacteria on crops; in addition, the bactericidal spectrum is expanded through binary compounding, the respective use amount is reduced, and the risk of drug resistance generation of pathogenic bacteria is reduced.
Description
The application is a divisional application with application number 2015110089285, application date 2015, 12 months and 30 days, and title "a bactericidal composition".
Technical Field
The present invention relates to a fungicidal composition, in particular to a fungicidal composition for protecting plants, crops or seeds from fungal diseases.
Background
At present, for disease control which is easy to generate resistance in agriculture, the pesticide varieties with different action mechanisms are optimally mixed, and if the mixture ratio is reasonable, the obvious synergistic effect can be generated, so that the field control effect is obviously better than that of each single agent. The bactericide containing a single active ingredient has certain defects in agricultural disease control, not only is pathogenic bacteria easy to generate drug resistance, but also is easy to cause pollution to food and environment after being continuously used for multiple times, and the defects can be overcome by reasonably mixing the active ingredients of the bactericide. The reasonable compounding ensures that the effective components generate synergistic action, can improve the control effect, reduce the using amount of the effective components, save the cost, delay the generation of drug resistance of pathogenic bacteria, and further can lighten or even avoid the pollution of pesticides to food and environment.
With regard to the activity of pesticides, in particular with regard to crop protection, one of the core problems of the research carried out in this technical field is the improvement of the properties, in particular in terms of biological activity, and the maintenance of this activity over a certain period of time.
Picarbitrazox, test code NF-171; CAS: 500207-04-5; tert-butyl [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] amino ] oxy ] methyl ] pyridin-2-yl ] carbamate; the molecular structural formula is:
picarbitrazox is an oxime ether bactericide developed by Nippon soda company and has a good control effect on downy mildew and epidemic diseases. Picarbitrazox is known from CN02817805. X.
Epoxiconazole (epoxyconazole), chemical name: (2RS, 3RS) -1- [3- (2-chlorophenyl) -2, 3-epoxy-2- (4-fluorophenyl) propyl ] -1-hydro-1, 2, 4-triazole, known as fungicides from EP 94564. The structural formula is as follows:
epoxiconazole is a novel, broad-spectrum, long-lasting fungicide developed by BASF corporation in 1985. Epoxiconazole belongs to a C-14 demethylase inhibitor in sterol biosynthesis. Epoxiconazole not only has good protection, treatment and eradication activity, but also has systemic and better residual activity. Epoxiconazole is mainly used for preventing and treating more than ten diseases such as damping off, powdery mildew, eyespot and the like on wheat, barley, rice, beet, rape, leguminous crops, vegetables, grapes, apples and the like. Meanwhile, the traditional Chinese medicine composition has a good treatment effect on sugarbeet brown spot, wheat glume blight, leaf blight, net blotch and the like.
Since the environmental and economic requirements for fungicides are constantly increasing nowadays, for example with regard to the spectrum of activity, toxicity, selectivity, application rates, residues and favourable feasibility of preparation, and since, for example, there may be problems with resistance to drugs, the development of new fungicides which are superior in some respects to existing fungicides is a constant task.
Disclosure of Invention
The object of the present invention is to provide a fungicidal composition which, at a reduced total amount of active compounds applied, has an improved activity against harmful fungi in terms of reduced application rates and an improved activity spectrum of the known compounds picarbtrazox and epoxiconazole (synergistic action).
We have found that the simultaneous, i.e. joint or separate, application of picarbrazox and epoxiconazole, or the sequential application of picarbrazox and epoxiconazole, leads to better control of harmful fungi than the individual compounds applied alone.
The invention provides a bactericidal composition, which is prepared by binary compounding of Picarbitrazox and epoxiconazole, so that the obtained composition has a gain effect on the prevention and treatment effects, the bactericidal spectrum is expanded, the effect of one medicine for multiple purposes is achieved, and the generation of drug resistance of germs is effectively slowed down or avoided. Surprisingly, the fungicidal activity of the fungicidal compositions according to the invention is significantly higher than the sum of the activities of the individual active compounds. In other words, there is an unpredictable, truly present synergistic effect, not just a supplementation of activity.
The synergistic effect is particularly pronounced when the active compounds are present in the fungicidal compositions of the present invention in a particular weight ratio. However, the weight ratio of the active compounds in the fungicidal compositions according to the invention can vary within certain limits.
The invention discloses a sterilization composition, which is realized by adopting the following technical scheme:
a germicidal composition, characterized by: contains active ingredients of Picarbitrazox and epoxiconazole, wherein the weight percentage of Picarbitrazox and epoxiconazole is 50:1-1:50, preferably 25:1-1:25, 10:1-1:10, and more preferably 5:1-1: 5.
The weight ratio of picarbtrazox and epoxiconazole in the present invention may be, for example, 50:1, 45:1, 40:1, 35:1, 30:1, 25:1, 20:1, 15:1, 10:1, 5:1, 1:5, 1:10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1: 50.
The sterilization composition is characterized in that: the sum of the mass of the Picarbitrazox and the epoxiconazole accounts for 5-90%, more preferably 10-80%, and still more preferably 20-60% of the mass of the bactericidal composition.
A method for controlling phytopathogenic fungi comprises applying a fungicidal composition to the pathogenic fungi and/or to the environment thereof, or to the plant, parts of the plant, seeds, the soil, the area, the material or the space.
A method for controlling phytopathogenic fungi, wherein Picarbitrazox and epoxiconazole are applied simultaneously, separately or sequentially.
A fungicidal composition comprising picarbtrazox and epoxiconazole together with a bulking agent and/or a surfactant.
A bactericidal composition can be prepared into any agriculturally allowable dosage form. The dosage form of the bactericidal composition is suspending agent, seed coating agent, suspoemulsion, wettable powder, water dispersible granules, microcapsule suspending agent, coated granules, extruded granules, missible oil, microemulsion, emulsion in water, effervescent tablets and ultra-low volume liquid.
The bactericidal composition is used for preventing and controlling fungi and bacteria on cereals, vegetables, alfalfa, soybeans, turf, wood, trees, fruit trees or horticultural plants.
Use of the fungicidal composition for the protection of plant propagation material and plant organs that grow subsequently.
The bactericidal composition is used for preventing and treating diseases of fruits and vegetables in the storage period.
The use of the fungicidal compositions for controlling phytopathogenic or saprophytic fungi and bacteria, when applied to the locus where control is desired.
A method of controlling phytopathogenic fungi of plants, plant parts, plant propagation material and plant organs which grow at a later time, which comprises applying said fungicidal composition in an agronomically effective and substantially non-phytotoxic application rate to the plants, plant parts, plant propagation material or to the soil or to a cultivation medium in which the plants are growing or in which it is desired to grow, by seed treatment, foliar application, stem application, drenching, instillation, pouring, spraying, misting, dusting, scattering or fuming.
The fungicidal compositions are particularly important for controlling a large number of fungi in various crop plants such as bananas, cotton, vegetable varieties (e.g., cucumbers, beans, tomatoes, and cucurbitaceae), barley, grasses, oats, coffee, potatoes, corn, fruit varieties, rice, rye, soybeans, grapevine, wheat, ornamentals, sugarcane, and a large number of seeds.
The fungicidal composition of the present invention has a strong activity against various plant pathogenic bacteria, and can exert a strong control effect on the prevention and treatment of plant diseases caused by plant pathogenic bacteria. The fungicidal composition of the present invention has excellent activity against a wide range of phytopathogenic fungi such as Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes, Deuteromycetes, etc.
The bactericidal composition also has very good bactericidal performance and can be used for preventing and controlling plant pathogenic bacteria. Such as pseudomonadaceae, rhizobiaceae, enterobacteriaceae, corynebacteriaceae and streptomycetaceae.
The fungicidal compositions of the invention can be used as foliar fungicides in crop protection, and also as fungicides for seed dressing and as soil fungicides.
The bactericidal composition can also be used for preventing and treating diseases of fruits and vegetables in the storage period.
The bactericidal composition is particularly suitable for controlling the following phytopathogens:
as the oomycetes, there may be exemplified, for example, Pythium species such as Rhizoctonia solani (Pythium ultium) of various crops; phytophthora species such as Phytophthora solani (Phytophthora infestans), Botrytis cinerea (Phytophthora capsici); pseudoperonospora species such as Pseudoperonospora cubeNsis (Pseudoperonospora cubeNsis), Pseudoperonospora humuli (Pseudoperonospora humuli); plasmopara species such as Plasmopara viticola; such as Peronospora brassiccus (Peronospora brassicae), Peronospora shallot (Peronospora destructor), Peronospora spinacia (Peronospora spiNacia), etc.
As Ascomycetes, there may be exemplified, for example, Erysiphe graminis (Erysiphegraminis) Erysiphe; sphaerotheca species such as vegetable powdery mildew (Sphaerotheca fuliginena); venturia bacteria such as Venturia iNaequalis (Venturia iNaequalis), Venturia piricola (Venturia nashicoloa); pyrenophora species such as barley Dictyophora (Pyrenophores); a bacterium belonging to the genus Cochliobolus such as barley speckled disease (Cochliobolus sativus); such as Sclerotinia sclerotiorum of vegetable Sclerotinia sclerotiorum (Sclerotinia sclerotiorum).
As the Basidiomycetes, there can be exemplified, for example, a fungus of the genus Bischospora such as PucciNiarecoNdita; tilletia species such as Tilletia foetida (Tilletia caries); ustilago sp.of barley smut (Ustilago Nuda), etc
As the deuteromycotina, there can be exemplified, for example, a strain of the genus Phoma such as Phoma asparagi (Phoma asparagi); septoria such as sheath blight of wheat (Septoria Nodorum); colletotrichum such as Colletotrichum cucurbitacearum (Colletotrichum lageNarium); pyricularia species such as Fusarium oxysporum (Pyricularia oryzae); botrytis ciNerea such as Botrytis ciNerea; alternaria such as Alternaria alternata (Alternaria mali) and Alternaria solaNi (Alternaria solaNi); cercospora species such as Cercospora (Cercospora betacola); a species of the genus amycolata such as the species Cladosporium persicinum (Cladosporium carpophilum); such as Rhizoctonia species of Rhizoctonia solaNi (Rhizoctonia solaNi) belonging to the genus Rhizoctonia.
Suitable crops include mainly field crops, such as maize, soybean, cotton, canola oil seeds, such as south Brassica napus (e.g. canola), turnip (Brassica rapa), mustard (b.juncea) (e.g. mustard (mustard)) and eruca sativa (Brassica carinata), rice, wheat, sugar beet, sugar cane, oats, rye, barley, millet, triticale, flax, vines and fruit or vegetable crops of various plant classes, such as rosaceae (Rosaceaesp) (e.g. pome fruits, such as apples and pears, and also stone fruits, such as apricots, cherries, almonds and peaches, berries, such as strawberries, theaceae (ribeoiae sp.), Juglandaceae (juaceae), jugaceae (jugaceae), Oleaceae (bearneae), macaca, fagochaetaceae (macaca), macaca (Oleaceae), fagus (Oleaceae), fagus canaceae (Oleaceae), fagus canaceae (Brassica carinata) and fagus carinata), Lauraceae (Lauraceae sp.), Musaceae (Musaceae sp.) (e.g., banana trees and musa basjora (plantains)), Rubiaceae (Rubiaceae sp.) (e.g., coffee), Theaceae (Theaceae sp.), firmianaceae (sterculaceae sp.), Rutaceae (Rutaceae sp.) (e.g., lemon, orange, and grapefruit); solanaceae (solanaceae sp.) (e.g. tomatoes, potatoes, peppers, eggplants), Liliaceae (Liliaceae sp.), compositaceae (Compositiae sp.) (e.g. lettuce, artichoke and chicory-including root chicory (root chicory), endive (endive) or common chicory), Umbelliferae (Umbelliferae sp.) (e.g. carrots, parsley, celery and celeries), Cucurbitaceae (Cucurbitaceae sp.) (e.g. cucumbers-including pickled cucumbers (pickling cuumber), squash, watermelons, cucurbits and melons), Alliaceae (Alliaceae sp.) (e.g. onions and leeks), Cruciferae sp. (e.g. white cabbage, red cabbage, broccoli, cabbage, cauliflower, broccoli, brussels sprouts, cabbage, parsley, radish, bean, lentils, beans (bean), lentils, beans, Chenopodiaceae (Chenopodiaceae sp.) (e.g., fodder beet, spinach sweet (spinach beet), spinach, beetroot), Malvaceae (e.g., okra), asparagines (e.g., asparagus); horticultural and forest crops; an ornamental plant; and genetically modified homologues of these crops.
The fungicidal combination of the present invention is preferably used for controlling, for example, the following diseases:
brown spot of "sugar beet" (Cercospora betacola), black root disease (Aphanomyces cochlioides), root rot (Thanatephorus cucumeris), leaf rot (Thanatephorus cucumeris);
brown spot of "peanut" (Mycosphaerella arachidis), black spot (Mycosphaerella berkeleyi);
powdery mildew (Sphaerotheca fuliginea), downy mildew (Pseudoperonospora cubensis), gummy stem blight (Mycosphaerella melonis), tendril-leaved mildew (Fusarium oxysporum), Sclerotinia sclerotiorum (Sclerotinia sclerotiorum), gray mold (Botrytis cinerea), anthracnose (Colletochytium orbiculare), scab (Cladosporium cuprinum), brown spot (Corynespora cassicola), seedling blight (Pyretheobaryanam, Rhizoctonia solani Kuhn), bacterial leaf spot (Pseudomonis annua pv. Lecrymas);
gray mold of "tomato" (Botrytis cinerea), leaf mold (Cladosporium fulvum), late blight (Phytophthora infestans);
gray mold of "eggplant" (Botrytis cinerea), blight (Corynespora melognae), powdery mildew (Erysiphe cichororaceae), downy mildew (mycosphaerella natrossii);
gray mold of "strawberry" (Botrytis cinerea), powdery mildew (Sohaerotheca humuli), anthracnose (Colletotrichum acutatum, collegiae), and epidemic disease (Phytophthora cactorum);
"onion" neck rot (Botrytis allii), Botrytis cinerea (Botrytis cinerea), white spot blight (Botrytis squamosa), downy mildew (Peronospora destructor);
root tumor disease of "cabbage" (Plasmodiophora brassicae), soft rot disease (Erwinia carotovora), downy mildew (Peronospora parasitica);
sclerotinia sclerotiorum (sclerotiorum) of "hyacinth bean", gray mold (Botrytis cinerea);
powdery mildew (Podosphaera leucotricha), scab (Venturia inaqualis), floral rot (Monilinia mali), black spot (Mycosphaerella pomi), rot (Valsa mali), Alternaria leaf spot (Alternaria mali), brown spot (Gymnospora yamadae), ring spot (Botryosphaeria berangeiana), anthracnose (Glomeella cingulata, Colletotrichum acutum), brown spot (Diplocarpon mali), fly spot (Zygophhia jamaicei), sooty mould (Gloeodedes pomagena);
powdery mildew of "persimmon" (Phyllantia kakicola), anthracnose (Gloeosporium kaki), alternaria angularis (Cercospora kaki);
brown rot (Monilinia fructicola), scab (Cladosporium carpophilum), Phomopsis sp.);
brown rot of "cherries" (Monilinia fructicola);
"grape" gray mold (Botrytis cinerea), powdery mildew (Uncinula necator), late rot (Glomerella cingulata, Colletotrichum acutum), downy mildew (Plasmopara viticola), anthracnose (Elsinoe ampelina), brown spot (Pseudocercospora vitis), black rot (Guignadia bidwellii);
scab of "pear" (Venturia nashi), brown spot (gynosporangium asiaticum), black spot (Alternaria kikuchiana), ring spot (Botryosphaeria berengiana), powdery mildew (phylactinia mali);
leaf spot of "tea" (Pestalotia theta), anthracnose (Colletotrichum theta-sinensis);
"citrus" scab (Elsinoe fawcetti), penicilliosis (Penicillium italicum), green mold (Penicillium digitatum), gray mold (Botrytis cinerea), black spot disease (Diaporthe citri), canker (xanthmonas campestris pv. citri);
powdery mildew (Erysiphe graminis f.sp.tritici), head blight (Gibberella zeae), leaf rust (Puccinia recandia), brown snow rot (Pythium iwayamai), red snow rot (monographeella nivalis), wheat basal rot (pseudococca thermophila rhizoctones), leaf blight (Septoria), glume blight (leptosporia nodorum), snow rot small-sized sclerotium disease (typhylla incarnata), snow rot large-sized sclerotium disease (myriospermotia borealis), and rhizoctonia (gaurea);
stripe disease (Pyrenophora graminea), sigatoka (Rhynchophorium secalis), loose smut (Ustilago tritici, U.nuda) of "barley";
"Rice" blast (Pyricularia oryzae), sheath blight (Rhizoctonia solani), bakanae disease (Gibberella fujikuroi), flax leaf spot (Cochliobolus niyabenus), seedling blight (Pythium graminicola), bacterial leaf blight (Xanthomonas oryzae), bacterial seedling blight (Burkholderia plantarii), brown streak disease (Acidovorax avenae), bacterial wilt (Burkholderia glumae)
Sclerotinia sclerotiorum (sclerotiorum) and powdery mildew (Erysiphe cichoracerum) of "tobacco";
gray mold of "tulip" (Botrytis cinerea);
snow rot large-grain Sclerotinia (Sclerotinia borealis) and Pythium aphanidermatum (Pythium aphanidermatum) of zoysia occidentalis;
powdery mildew of "orchard grass" (Erysiphe graminis);
purpurea (Cercospora kikuchi), downy mildew (Peronospora Manshurica), stem blight (Phytophthora sojae) of "soybean";
potato and tomato late blight (Phytophthora infestans).
The bactericidal composition can well prevent and treat pathogenic bacteria and medicament-resistant bacteria causing the following diseases: damping off and bakanae disease of rice seedbed; diseases of cotton in seedling stage such as damping off, anthracnose, damping off and red rot; vegetable seedbed diseases such as damping-off anthracnose, damping-off, phytophthora root rot, gray mold, leaf rust, spot disease, anthracnose and early phytophthora root rot of tomato; downy mildew, powdery mildew, gray mold, anthracnose, blight, black spot and brown spot of cucumber; anthracnose and gray mold of strawberry; powdery mildew, anthracnose and withered vine disease of pumpkin; white spot leaf blight, black spot, gray mold and gray rot of onion; powdery mildew, gray mold and black blight of eggplant; black spot of green Chinese onion; white spot and black spot of Chinese cabbage; sclerotinia rot and gray mold of bell peppers; powdery mildew, anthracnose and withered vine disease of cucumber; powdery mildew, anthracnose and vine blight of melon; gray mold of lettuce; black spot and gray mold of red bayberry; powdery mildew, anthracnose, gray mold and leaf cast of persimmon; gray mold of citrus; scab, black spot and early blight of pear; gray mold, anthracnose, brown spot, black vine, withered vine, viscidity blight and branch expansion disease of grape; scab, gray spot, anthracnose of peach; scab, alternaria, early blight, brown spot, coal spot, black spot and brown rot of apple; stem blight, anthracnose, gray mold and sclerotinia of mung bean; anthracnose, gray mold and sclerotinia of kidney beans; ring spot of broad bean; soybean purpura; powdery mildew of tobacco, brown spot and spot of beet; anthracnose, wheel spot and new bud blight and gray mold of tea; plant diseases such as scab, anthracnose, gray mold and powdery mildew of flowers. The bactericidal composition can particularly well prevent and treat phytopathogen and medicament-resistant bacteria of epidemic diseases, powdery mildew and botrytis of tomatoes, cucumbers, eggplants, strawberries, grapes, peaches and oranges.
The bactericidal composition is particularly suitable for preventing and treating apple, banana, grape, orange, mango, rice, wheat, corn, potato, soybean, tomato, pepper, cucumber, eggplant, grape downy mildew, early blight, late blight, black shank, scab, leaf spot, anthracnose, powdery mildew, wilting disease, damping off and damping off.
Crops treated with the fungicidal compositions of the present invention are, for example, but not limited to, cereals, vegetables, alfalfa, soybeans, turf, wood, trees, fruit trees, or horticultural plants.
The sterilization mixture can also be used for preventing and treating diseases of fruits and vegetables in the storage period. For example fruit decay caused by the following pathogens:
aspergillus species, such as Aspergillus flavus;
botrytis (Botrytis) species, such as Botrytis cinerea (Botrytis cinerea);
penicillium (Penicillium) species, such as Penicillium expansum (Penicillium expansum) and p.purpurogenum;
sclerotinia (Sclerotinia) species, such as Sclerotinia (sclerotiorum);
verticillium species, for example Verticillium alboatrum.
The bactericidal composition is also particularly suitable for preventing and treating stalk rot, green mold, penicillium and anthracnose of fruits and vegetables in the storage period.
The bactericidal mixture can also be used for preventing and treating seed-borne and soil-borne diseases. Such as seed-and soil-borne rot and wilting diseases and seedling diseases caused by the following pathogens:
alternaria species, such as Alternaria brassicolo (Alternaria brassicolo);
species of the genus Saccharomycopsis (Aphanomyces), e.g. Saccharomycopsis phaseoloides (Aphanomyces)
euteiches) ;
Species of the genus Ascochyta (Ascochyta), such as Ascochyta lentis;
aspergillus, such as Aspergillus flavus;
cladosporium species, such as Cladosporium herbarum (Cladosporium herbarum);
species of the genus Sporotrichum, such as Sporotrichum graminum;
(conidia form: Deerhodomyces, Syn: Helminthosporium);
anthrax species, such as Colletotrichum fuliginosum (Colletotrichum coccodes);
fusarium species, such as Fusarium flavum;
species of the genus gibberella, such as gibberella zeae;
species of the genus Septoria (macrophosina), e.g. Septoria phaseoloides (macrophosina)
phaseolina) ;
The stippled shells belong to species, such as the small stippled shells of snow rot;
penicillium species, such as penicillium expansum;
phaeosphaeria species, such as Phaeosphaeria nodorum;
phoma species, such as Phoma nigra (Phoma linggam);
phomopsis (Phomopsis), such as Phomopsis sojae;
phytophthora species, such as Phytophthora infestans (Phytophthora cacorum);
pyrenophora species, such as Pyrenophora graminea (Pyrenophora graminea);
pyricularia species (Pyricularia) such as Pyricularia oryzae (Pyricularia oryzae);
pythium species, such as pythium ultimum;
rhizoctonia species, such as rhizoctonia solani;
rhizopus species (Rhizopus) such as Rhizopus oryzae (Rhizopus oryzae);
sclerotium species, such as Sclerotium rolfsii;
corallina species (Typhula) such as Scleronaria carolina (Typhula incana);
verticillium species, such as Verticillium dahliae (Verticillium dahliae).
The bactericidal composition of the present invention also has an excellent bactericidal effect against bacteria that exhibit resistance to existing bactericides. Examples of the microorganisms include Botrytis cinerea (Botrytis cinerea), Limnosphaera betanae (Cercospora betacola), Venturia inaequalis (Venturia inaqualis), Venturia piricola (Venturia nasicola), and the like.
A method of controlling phytopathogenic fungi of plants, plant parts, plant propagation material and plant organs which grow at a later time, comprising applying the fungicidal composition of the invention in an agronomically effective and substantially non-phytotoxic application rate to the plants, plant parts, plant propagation material or to the soil or to a cultivation medium in which the plants are growing or in which it is desired to grow, by seed treatment, foliar application, stem application, drench, drip, pour, spray, mist, dusting, scattering or smoking.
The fungicidal composition of the present invention can be used for the prevention and treatment of various diseases generated when agricultural and horticultural crops including flowers, lawns, pastures, and the like are cultivated by seed treatment, foliage application, soil application, or water surface application.
The present invention provides a method for controlling phytopathogenic fungi by acting a fungicidal composition on the pathogenic fungi and/or their environment or on the plant, parts of the plant, plant propagation material, the soil, areas, materials or spaces.
The fungicidal compositions of the present invention are useful for the protection of plant parts, plant propagation material and plant organs that grow at a later time.
The bactericidal composition can treat all plants and plant parts. "plant" means all plants and plant populations such as desirable and undesirable wild plants, cultivars, and plant varieties (whether or not protected by a plant variety or plant cultivar rights-to-human). Cultivated plants and plant varieties may be plants obtained by conventional propagation and cultivation methods, which may be supplemented or supplemented by one or more biotechnological methods, for example using dihaploids, protoplast fusion, random and directed mutations, molecular or genetic markers, or using bioengineering and genetic engineering methods. Plant parts are understood to mean all parts and organs of plants above and below the ground, such as shoots, leaves, flowers and roots, such as leaves, needles, stems, branches, flowers, fruit bodies, fruits and seeds, and also roots, bulbs and rhizomes. Also plants and vegetative and generative propagation material, for example cuttings, bulbs, rhizomes, runners and seeds, belong to the plant part.
The term "plant propagation material" is understood to mean all reproductively competent plant parts, such as seeds, which can be used for the propagation of the latter, and also vegetative materials, such as cuttings or tubers (e.g. potatoes). Thus, plant parts as used herein include plant propagation material. Mention may be made, for example, of seeds, roots, fruits, tubers, bulbs, rhizomes and plant parts. Germinated plants and useful plants to be inhibited after germination or after emergence from the soil. The young plants can be protected prior to transplantation by a total or partial treatment by dipping.
Preferred propagation material of the present invention is a seed. Examples of the method of seed treatment include a method of diluting a liquid or solid chemical, a method of directly immersing seeds in a liquid solution without dilution to allow the chemical to permeate the seeds, a method of mixing a solid chemical or liquid chemical with seeds to coat the seeds and thereby adhering the chemical to the surfaces of the seeds, and a method of spraying the chemical to the vicinity of the seeds while planting.
A plant part and plant organ that subsequently grows is any part of a plant produced from plant propagation material, such as seeds. Plant parts, plant organs and plants may also benefit from the pathogenic damage protection obtained by applying the fungicidal composition to plant propagation material. Certain plant parts and plant organs that grow after certain locations may also be considered plant propagation material, which itself may be applied (or treated) with the fungicidal composition; thus plants, other plant parts and other plant organs produced from the treated plant parts and treated plant organs may also benefit from the application of the germicidal composition.
The fungicidal compositions of the present invention may also be used to prevent or control a variety of pathogenic or saprophytic fungi and bacteria in soils or cultivation media. Examples of soil-borne fungal pathogens include Alternaria (Alternaria spp.), Ascochyta (Ascochyta spp.), Botrytis cinerea (Botrytis cinerea, Cercospora spp., ergot (cladceps purpurea), Cochliobolus graminis (Cochliobolus sativus), colletotrichum (colletotrichum spp., epiphyte (Epicoccum spp.), Fusarium graminearum (Fusarium graminearum), Alternaria oryzae (Fusarium moniliforme), Fusarium oxysporum (Fusarium oxysporum), Fusarium moniliforme (Fusarium oxysporum), Fusarium solani (Fusarium oxysporum), Fusarium oxysporum (pyelomycelium oxysporum), Fusarium oxysporum (pyelomyceliophthora), Rhizoctonia solanum (pyelospora oryzae), Rhizoctonia solanum, Rhizoctonia solanum, Rhizoctonia solanum, Rhizoctonia solanum, Rhizoctonia solanum, Rhizoctonia solanum, Rhizoctonia solanum, ustilago shaft (Sphacelotheca reilliana), Tilletia spp, Sclerotia carolina, Ustilago occulta, Ustilago spp or Verticillium spp.
The soil germs include rhizoctonia solani, fusarium, phytophthora, damping-off, root rot, pythium, botrytis cinerea, soft rot and the like. Under general conditions, soil pathogenic bacteria can generate a large amount of bacteria, as long as conditions are favorable for growth and development of the pathogenic bacteria and hosts are susceptible, the pathogenic bacteria can propagate in a large amount and infect the hosts, under the host infected with diseases, the pathogenic bacteria can enter a continuous pathogenic period, propagate and diffuse in a large amount along with continuous cropping of crops, but then nutrients are consumed, or when soil conditions such as temperature, humidity and the like are unfavorable for the pathogenic bacteria, the pathogenic bacteria can enter a dormant period. When the host with disease does not exist, soil-borne disease bacteria can survive in soil, and the soil-borne disease bacteria can survive on the root surface or the fallen leaves of the non-host except the soil-borne disease bacteria with wide host range and have the saprophytic competitive ability. However, different germs are different, and like fusarium can almost survive in soil indefinitely.
The culture medium of the present invention refers to a support capable of rooting and growing crops, such as: examples of the raw material include sand, pumice, vermiculite, diatomaceous earth, agar, gel, polymer, asbestos, wood chips, and bark.
Examples of methods for applying a chemical to soil include a method in which a liquid chemical is diluted in water or applied without dilution directly to the roots of a plant or a seedling bed for raising seedlings, a method in which granules are sown to the roots of a plant or a seedling bed for raising seedlings by spraying a powder, a water dispersible granule or the like to soil and mixing with the whole soil before sowing, and a method in which a powder, a water dispersible granule or the like is diluted and sprayed to a planting hole or a planting furrow before sowing or planting a plant, and sowing is performed.
It is another object of the present invention to provide a method of controlling phytopathogenic fungi of plants, parts of plants, plant propagation material and plant organs which grow at a later time, which comprises applying the fungicidal composition of the present invention to the plants, parts of plants, plant propagation material or to the soil or to the cultivation medium in which the plants are growing or in which it is desired to grow, in an agronomically effective and substantially non-phytotoxic manner by seed treatment, foliar application, stem application, drench, drip, pour, spray, mist, dusting, scattering or smoking.
The germicidal compositions of the present invention may be applied by various treatment methods, such as:
-spraying a liquid comprising the fungicidal composition onto the above-ground parts of the plant;
-dusting, incorporating granules or powders in the soil, spraying around said plants and, in the case of tree injection or painting;
-coating or film coating the seeds of the plants.
When the preservative is used for preservation and fresh-keeping of picked fruits and vegetables, the preservative is usually diluted by water by 200 times and 2000 times, and the fruits are leached out after being soaked.
The present invention provides a method for controlling plant pathogenic bacteria, which can be a treatment, prevention or eradication method.
The fungicidal composition of the present invention can be used in the form of a conventional chemical preparation, for example, emulsifiable concentrate, wettable powder, suspension, liquid, granule, seed coating, and the like, and the application amount thereof varies depending on the mixing ratio of the active ingredients, weather conditions, the chemical preparation, the application time, the application method, the application site, the control of target pests, the target crop, and the like.
A method for controlling phytopathogenic fungi, wherein Picarbitrazox and epoxiconazole are applied simultaneously, separately or sequentially.
Treatment according to the invention may produce superadditive ("synergistic") effects. For example, depending on the application rate and/or broadening the activity spectrum and/or increasing the activity of the fungicidal compositions used according to the invention, it is possible to obtain the following effects: better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, improved flowering performance, easier harvesting, accelerated ripening, higher harvest yields, larger fruits, higher plant height, greener leaf color, earlier flowering, higher quality or nutritional value of the harvested product, higher sugar concentration in the fruit, better storage stability and/or processability of the harvested product, which exceeds the actually predicted effects.
The treatment method of the invention may also be used to treat propagation material such as tubers or rhizomes, and may be used to treat seeds, seedlings or transplanted (packing out) seedlings and plants or transplanted plants. This processing method can also be used to process roots. The treatment method of the present invention can also be used for treating the above-ground parts of plants such as the stems, stems or stalks, leaves, flowers and fruits of the plants concerned.
Typically for leaf treatment: 0.1 to 10000g/ha, preferably 10 to 1000g/ha, more preferably 50 to 500 g/ha; for dipping or instillation administration, the dosage may even be reduced, particularly when an inert substrate such as asbestos or perlite is applied;
-for seed treatment: 2-5000g/100kg of seeds, preferably 3-1000g/100kg of seeds;
-applying a treatment to the soil or water surface: 0.1 to 10000g/ha, preferably 1 to 1000 g/ha;
for the preservation of picked fruits and vegetables, 200 times and 2000 times of liquid can be diluted, and the fruits can be drained after being soaked.
The above-mentioned dosages are only typical exemplary dosages, and the person skilled in the art will adjust the application rate in the actual application according to the actual circumstances and needs, in particular according to the nature of the plants or crops to be treated and the severity of the germs.
The picarbtrazox of the present invention is administered in combination/association with epoxiconazole. Comprising separate, sequential or simultaneous administration of picarbtrazox and epoxiconazole. Preferably, the picarbtrazox and epoxiconazole are combined in the form of a composition comprising picarbtrazox and epoxiconazole.
The compositions of the present invention may be presented in a dosage form, i.e., the components of the composition are mixed, or the components of the composition may be provided in a single dose, mixed in a tank or container prior to use, and then diluted to the desired concentration. The preparation form provided by the invention is preferably the main form.
As a further improvement of the invention, the bactericidal composition of the invention can be formulated into any agriculturally acceptable dosage form.
As a further improvement, the dosage form of the bactericidal composition provided by the invention is a suspending agent, a seed coating agent, wettable powder, water dispersible granules, a microcapsule suspending agent, coated granules, extruded granules, missible oil, a microemulsion, an emulsion in water, an effervescent tablet, an ultra-low volume liquid and a suspoemulsion.
The bactericidal composition comprises Picarbitrazox, epoxiconazole, a filler and/or a surfactant.
The bactericidal composition comprises 5% -90% of Picarbitrazox and epoxiconazole.
The bactericidal composition comprises 10% -80% of Picarbitrazox and epoxiconazole.
The bactericidal composition comprises 20% -60% of Picarbitrazox and epoxiconazole.
According to the present invention, the term "filler" refers to a natural or synthetic organic or inorganic compound that can be combined or associated with an active compound to make it easier to apply to a subject (e.g. plants, crops or grasses). Thus, the filler is preferably inert, at least should be agriculturally acceptable. The filler may be solid or liquid.
The inactive medium that can be used in the present invention may be either solid or liquid, and examples of the solid medium material include: examples of the inorganic filler include vegetable powders (for example, particles of soybean powder, starch, cereal powder, wood powder, bark powder, saw dust, walnut shell powder, bran, cellulose powder, coconut shell, corn cob, and tobacco stalk, and residues after extraction of plant essence), paper, saw dust, synthetic polymers such as ground synthetic resins, clays (for example, kaolin, bentonite, and acid china clay), and talc powders. Silica (for example, diatomaceous earth, silica sand, mica, hydrous silicic acid, calcium silicate), activated carbon, natural minerals (for example, pumice, attapulgite, zeolite, etc.), calcined diatomaceous earth, sand, plastic media (for example, polyethylene, polypropylene, polyvinylidene chloride, etc.), inorganic mineral powders such as potassium chloride, calcium carbonate, calcium phosphate, etc., chemical fertilizers such as ammonium sulfate, ammonium phosphate, urea, ammonium chloride, etc., and soil fertilizers, and these may be used alone or in combination of 2 or more.
Examples of the liquid vehicle material that can be used include water, alcohols (e.g., methanol, ethanol, isopropanol, butanol, and ethylene glycol), ketones (e.g., acetone, methyl ethyl ketone, diisobutyl ketone, and cyclohexanone), ethers (e.g., diethyl ether, dioxane, methyl cellulose, and tetrahydrofuran), aliphatic hydrocarbons (e.g., kerosene, and mineral oil), aromatic hydrocarbons (e.g., benzene, toluene, xylene, mineral spirits, alkyl naphthalenes, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbons, and chlorobenzene), halogenated hydrocarbons, amides, sulfones, dimethyl sulfoxide, mineral and vegetable oils, and animal oils.
Examples of the surfactant that can be used for emulsifying, dispersing, and/or wetting the active ingredient compound include polyacrylic acid salts such as fatty alcohol polyoxyethylene ether, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid ester, phosphoric acid ester of polyoxyethylene alcohol or phenol, fatty acid ester of polyhydric alcohol, alkaryl sulfonic acid, naphthalene sulfonic acid polymer, lignosulfonate, branched polymer of high molecular comb, butyl naphthalene sulfonate, alkylaryl sulfonate, sodium alkylsulfosuccinate, oils and fats, condensation product of fatty alcohol and ethylene oxide, and alkyltaurate, and protein hydrolysates. Suitable oligosaccharides or polymers are based, for example, on ethylene monomers, acrylic acid, polyoxyethylene and/or polyoxypropylene alone or in combination with, for example, (poly) alcohols or (poly) amines.
For dispersion stabilization, attachment and/or binding of the active ingredient compounds, auxiliaries such as xanthan gum, magnesium aluminum silicate, gelatin, starch, cellulose methyl ether, polyvinyl alcohol, polyvinyl acetate and natural phospholipids (such as cephalin and lecithin) as well as synthetic phospholipids, bentonite, sodium lignosulfonate and the like can be used.
Wherein the antifreezing agent can be selected from ethylene glycol, propylene glycol, glycerol, and sorbitol. As the deflocculant for the suspendable product, an auxiliary such as a naphthalenesulfonic acid polymer, a polymeric phosphate, or the like can be used.
As the defoaming agent, a silicone defoaming agent can be used.
Colorants which may be used, for example, inorganic pigments such as iron oxide, titanium oxide and prussian blue; and organic pigments/dyes: alizarin dyes, azo dyes, and metal phthalocyanine dyes; and trace elements such as iron, manganese, boron, copper, cobalt, molybdenum and zinc salts.
Optionally, further additional components, such as protective colloids, binders, thickeners, thixotropic agents, penetrating agents, stabilizers, masking agents, can also be included.
The formulations of the invention can be prepared by mixing the active compounds with the customary additives in a known manner. Such as conventional extenders as well as solvents or diluents, emulsifiers, dispersants, and/or binders or fixatives, wetting agents, water repellents, if desired siccatives and colorants, stabilizers, pigments, defoamers, preservatives, thickeners, water and other processing aids.
The germicidal compositions of the present invention include not only those that are immediately applicable to the subject to be treated by means of a suitable device, such as a spraying or dusting device, but also concentrated commercial compositions that are diluted prior to application to the subject.
The compositions of the invention containing picarbrazox and epoxiconazole may also be administered in combination with other active ingredients, for example to broaden the spectrum of activity or to prevent the development of resistance. Such as fungicides, bactericides, attractants, insecticides, acaricides, nematicides, growth regulators, herbicides, safeners, fertilizers or semiochemicals and the like.
The active compounds picarbtrazox and epoxiconazole can be applied simultaneously, or separately, or sequentially, the order of application in the case of separate application usually having no effect on the results of the control.
The compositions of the present invention may be presented in a dosage form, i.e., the components of the composition are mixed, or the components of the composition may be provided in a single dose, mixed in a tank or container prior to use, and then diluted to the desired concentration. The preparation form provided by the invention is preferably the main form.
The fungicidal compositions of the invention have improved activity against harmful fungi at a reduced total amount of active compound applied (synergistic). The bactericidal composition of the present invention also has an excellent bactericidal effect against bacteria that exhibit resistance to existing bactericides.
According to the bactericidal composition, the Picarbitrazox and the epoxiconazole are subjected to binary compounding, so that the obtained composition has a gain effect on the prevention and treatment effect, the bactericidal spectrum is expanded, the effect of one medicine for multiple purposes is achieved, and the drug resistance of germs is effectively slowed down or avoided. Surprisingly, the fungicidal activity of the fungicidal compositions according to the invention is significantly higher than the sum of the activities of the individual active compounds, there being an unpredictable, truly occurring synergistic effect, not merely a supplementation of the activities.
The synergistic effect is particularly pronounced when the active compounds are present in the fungicidal compositions of the present invention in a particular weight ratio. However, the weight ratio of the active compounds in the fungicidal compositions according to the invention can vary within certain limits.
The invention provides a bactericidal composition which has higher activity and longer activity retention. The bactericidal composition has low dosage and low toxicity, and can control fruits, vegetables and seeds with fungal diseases.
Detailed Description
The invention will be further illustrated by the following specific formulation examples.
Formulation examples
Example 1: 40% Picarbitrazox epoxiconazole wettable powder
10% of Picarbtrazox, 30% of epoxiconazole, 6% of lignosulfonate, 4% of soapberry powder and 100% of attapulgite, mixing the formula materials, uniformly stirring in a stirring kettle, and uniformly mixing through a jet mill to obtain the 40% Picarbtrazox epoxiconazole wettable powder.
Example 2: 50% Picarbitrazox epoxiconazole wettable powder:
5 percent of Picarbuzox, 45 percent of epoxiconazole, 8 percent of naphthalene sulfonic acid formaldehyde condensate, 5 percent of tea seed cake and 100 percent of kaolin are added, the formula materials are mixed and evenly stirred in a stirring kettle, and the mixture is evenly mixed after passing through a jet mill, so as to prepare the 50 percent Picarbuzox and epoxiconazole wettable powder.
Example 3: 40% Picarbitrazox epoxiconazole wettable powder
10% of Picarbtrazox, 30% of epoxiconazole, 7% of fatty alcohol-polyoxyethylene ether, 5% of wetting penetrant F and 100% of diatomite, mixing the formula materials, uniformly stirring in a stirring kettle, and uniformly mixing through an airflow pulverizer to prepare the 40% Picarbtrazox epoxiconazole wettable powder.
Example 4: 40% Picarbitrazox epoxiconazole water dispersible granule
Picarbitrazox 20%, epoxiconazole 20%, calcium alkyl benzene sulfonate 8%, nekal BX 6%, ammonium sulfate 2% and bentonite 100%, mixing the above formula materials uniformly, kneading by using an ultramicro jet mill, adding into a fluidized bed granulation dryer for granulation, drying, screening, sampling, analyzing and mixing to obtain the 40% Picarbitrazox epoxiconazole water dispersible granule.
Example 5: 60% Picarbitrazox epoxiconazole water dispersible granule
20% of Picarbitrazox, 40% of epoxiconazole, 7% of fatty acid polyoxyethylene ether, 4% of sodium dodecyl sulfate, 2.8% of aluminum chloride and 100% of kaolin, uniformly mixing the formula materials, kneading the materials by using an ultramicro jet mill, adding the materials into a fluidized bed granulation dryer for granulation, drying and screening, and then sampling, analyzing and mixing to obtain the 60% Picarbitrazox epoxiconazole water dispersible granule.
Example 6: 90% Picarbitrazox epoxiconazole water dispersible granule
The 90% Picarbitrazox epoxiconazole water dispersible granule is prepared by adding 100% of Picarbitrazox 40%, 50% of epoxiconazole, 1% of polyoxyethylene octylphenol ether sulfate, 1% of sodium dodecyl benzene sulfonate, 1% of sodium carbonate and white carbon black into the formula, uniformly mixing the formula materials, kneading the materials by using an ultramicro jet mill, adding the materials into a fluidized bed granulation dryer for granulation, drying and screening, and then sampling and analyzing the materials.
Example 7: 30% Picarbitrazox epoxiconazole suspension
The preparation method comprises the following steps of mixing Picarbtrazox 10%, epoxiconazole 20%, polycarboxylate 6%, silicone oil 0.3%, xanthan gum 0.9%, diethylene glycol 2.5%, and deionized water to 100%, mixing the thickening agent and the antifreezing agent, then uniformly mixing the components except for the effective components through high-speed shearing, adding the effective components, performing ball milling in a ball mill for 2-3 hours to enable the particle size to be below 5 mu m, and thus obtaining the 30% Picarbtrazox epoxiconazole suspending agent.
Example 8: 20% Picarbitrazox epoxiconazole suspension
The preparation method comprises the following steps of mixing Picarbtrazox 10%, epoxiconazole 10%, naphthalene sulfonic acid formaldehyde condensate 6%, hydroxyethyl cellulose 0.7%, silicone compounds 0.1%, polyethylene glycol 2% and deionized water to 100%, mixing the thickening agent and the antifreezing agent, uniformly mixing the components except for the effective components through high-speed shearing, adding the effective components, and performing ball milling in a ball mill for 2-3 hours to enable the particle size to be below 5 mu m, thus obtaining the 20% Picarbtrazox epoxiconazole suspending agent.
Example 9: 40% Picarbitrazox epoxiconazole suspending agent
15% of Picarbitrazox, 25% of epoxiconazole, 8% of lignosulfonate, 1% of magnesium aluminum silicate, 0.2% of silicone, 2.8% of glycerol and 100% of deionized water, mixing the thickening agent and the antifreezing agent, uniformly mixing the components except the active ingredient through high-speed shearing, adding the active ingredient, and performing ball milling in a ball mill for 2-3 hours to ensure that the particle size is below 5 mu m, thus obtaining the 40% Picarbitrazox epoxiconazole suspending agent.
Example 10: 20% Picarbitrazox epoxiconazole suspension emulsion
Picarbitrazox 10%, epoxiconazole 10%, SOLVESSOTM10010%, calcium alkyl benzene sulfonate salt 7%, methyl cellulose 1.2%, propylene glycol 2.4%, C8~10Fatty alcohol 0.4%, Tween 807%, and water added to 100%; a finely ground Picarbitrazox suspension was added to the continuous phase containing the fluorocyclozole and mixed to obtain a 20% Picarbitrazox-epoxiconazole suspension.
Example 11: 20% Picarbitrazox epoxiconazole suspension emulsion
5% of Picarbitrazox, 15% of epoxiconazole, 6% of lignosulfonate, 0.8% of xanthan gum, 2.5% of ethylene glycol, and SolvessoTM10015%, silicone oil 0.2%, 600# phosphate ester 5%, water added to 100%. A finely ground Picarbitrazox suspension was added to the continuous phase containing the fluorocyclozole and mixed to obtain a 20% Picarbitrazox-epoxiconazole suspension.
Example 12: 30% Picarbitrazox epoxiconazole suspension emulsion
The preparation method comprises the following steps of (1) adding 20% of Picarbtrazox, 10% of epoxiconazole, 7% of naphthalene sulfonic acid formaldehyde condensate, 3% of saponin powder, 1.1% of phenolic resin, 2% of triethylene glycol, 0.1% of silicone, 400#6% of agricultural emulsion and water to 100%, adding a finely ground Picarbtrazox suspension phase into a fluorine-containing epoxiconazole continuous phase, and mixing to obtain a 30% Picarbtrazox epoxiconazole suspension emulsion.
Example 13: 22.5% Picarbitrazox epoxiconazole microemulsion
Picarbitrazox 10%, epoxiconazole 12.5%, N-methyl pyrrolidone 6%, ethylene oxide-propylene oxide block copolymer 4%, magnesium alkyl diphenyl ether disulfonate 5%, silicone compound 0.4%, toluene 3%, propylene glycol 2%, epichlorohydrin 1.1%, deionized water to 100% to make 22.5% Picarbitrazox epoxiconazole microemulsion.
Example 14: 5% Picarbitrazox epoxiconazole microemulsion
Picarbitrazox 1%, epoxiconazole 4%, cyclohexanone 5%, agricultural milk 500#4%, agricultural milk 700#5%, C8~100.2 percent of fatty alcohol, 2.5 percent of ethyl acetate, 2 percent of polyethylene glycol, 1.4 percent of tributyl phosphate and deionized water are added to 100 percent to prepare 5 percent Picarbitrazox epoxiconazole microemulsion.
Example 15: 50% Picarbitrazox epoxiconazole water dispersible granule
The 50% Picarbitrazox epoxiconazole water dispersible granule is prepared by adding 100% of Picarbitrazox 30%, 20% of epoxiconazole, 1% of polyoxyethylene octylphenol ether sulfate, 1% of sodium dodecyl benzene sulfonate, 1% of sodium carbonate and white carbon black into the formula, uniformly mixing the formula materials, kneading the materials by using an ultramicro jet mill, adding the materials into a fluidized bed granulation dryer for granulation, drying and screening, and then sampling and analyzing.
Example 16: 10% Picarbitrazox epoxiconazole water emulsion
5% of Picarbtrazox, 5% of epoxiconazole, 4% of 600# phosphate, 7% of propanol, 600#3% of agricultural emulsion, 0.7% of xanthan gum, 2.4% of propylene glycol, 4% of toluene and 100% of deionized water, and preparing the 10% Picarbtrazox epoxiconazole water emulsion.
Example 17: 11% Picarbitrazox epoxiconazole emulsifiable concentrate
1% of Picarbitrazox, 10% of epoxiconazole, 5% of ethoxylated castor oil, 3% of calcium dodecylbenzene sulfonate, and 3% of SolvessoTM 200 to 100% was added and stirred until a clear homogeneous phase was obtained, giving 11% Picarbitrazox epoxiconazole cream.
Example 18: 20% Picarbitrazox epoxiconazole microcapsule suspension-suspension
Picarbitrazox 10%, epoxiconazole 10%, Synperonic PE/6415%, citric acid 0.05%, water 10%, PAPI 20%, SOLVESSOTM1005 percent, dispersant LFH0.15 percent, defoamer 0.16 percent and urea 5.5 percent; water is complemented to 100 percent; mixing PAPI, epoxiconazole and SolvessoTM100 into an aqueous solution containing Synperonic PE/64 to form an emulsion.Then the catalyst is added and reacted for 2 hours at 50 ℃ while heating and maintaining the temperature. Cooling to obtain the microcapsule of epoxiconazole. Synperonic PE/64, a dispersant LFH, a defoaming agent, urea, Picarbitrazox and water are mixed uniformly according to a proportion and are sanded to prepare the suspending agent. The obtained epoxiconazole microcapsule is added into a Picarbitrazox suspending agent, and the mixture is stirred uniformly to obtain a 20 percent Picarbitrazox epoxiconazole microcapsule suspension-suspending agent.
Example 1922.5% Picarbitrazox epoxiconazole seed coating
10% of Picarbitrazox, 12.5% of epoxiconazole, 10% of fatty alcohol-polyoxyethylene ether sulfosuccinic acid monoester disodium, 5% of modified calcium lignosulfonate, 1% of xanthan gum and 1% of bentonite. 5 percent of glycerol,
PVP-K301 percent, and the balance being 100 percent, evenly mixing the components in proportion, and preparing the 22.5 percent Picarbitrazox epoxiconazole seed coating agent by sanding.
Example 2050% Picarbitrazox epoxiconazole coated granules
Picarbitrazox 20%, epoxiconazole 30%, polyethylene glycol 3%, highly dispersed silicic acid 1%,
the calcium carbonate was made up to 100% and the finely ground active ingredient was homogeneously applied to a carrier wetted with polyethylene glycol in a mixer in such a way that 50% dust-free coated granules of picarbtrazox epoxiconazole were obtained.
Example 21 picarbtrazox 40% and epoxiconazole 60% were mixed homogeneously.
Example 22 picarbtrazox 50% and epoxiconazole 50% were mixed well.
The proportion of the above embodiment is weight percentage.
Biological test example:
firstly, determination of drug effect:
synergistic effects exist when the effect of the active compound combination exceeds the sum of the effects when the active compounds are administered separately. The expected effect of a particular combination of two active compounds can be calculated using the so-called "Colby formula" (cf. S.R. Colby, "working Synergistic and antibacterial Responses of pharmaceutical compositions", Weeds 1967,15, 20-22) if
X is the activity when active compound A is used in mg/ha or mppm concentration;
y is the activity when active compound B is used in an amount of ng/ha or at a concentration of nppm, expressed as a percentage of the untreated control;
e is the activity when using the active compounds A and B in amounts of m and n g/ha or in concentrations of m and n ppm,
then
If the actually observed activity (O) is greater than the expected activity (E), the composition has a synergistic effect.
The following biological test examples are provided to illustrate the present invention. However, the present invention is not limited to these examples.
Test 1 epidemic test (tomato)/protective efficacy test
Solvent: 24.5 parts by weight of acetone
24.5 pbw of dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To obtain a suitable preparation of the active compound, 1 part by weight of active compound is mixed with an amount of solvent and emulsifier and the concentrate is diluted with water to the desired concentration.
To test for protective activity, young plants are sprayed with the preparation of active compound at a certain application rate. After the sprayed coating has dried, the plants are inoculated with an aqueous spore suspension of Phytophthora infestans. The plants were then placed in an incubator at about 20 ℃ and 100% relative atmospheric humidity.
The test results were evaluated 3 days after incubation. 0% indicates the drug effect corresponding to the control, and 100% indicates no disease.
| Active compound | The rate of application of the active compound(s), ppm | actual medicine Effective, is% | Expectation of "Colby formula" calculation Value% |
| Picarbutrazox | 1 | 44 | - |
| Picarbutrazox | 10 | 53.4 | - |
| Picarbutrazox | 50 | 69.4 | - |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Amyl ester | 1 | 0 | - |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Amyl ester | 10 | 0 | - |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Amyl ester | 50 | 5 | - |
| Epoxiconazole | 1 | 0 | - |
| Epoxiconazole | 10 | 0 | - |
| Epoxiconazole | 25 | 11.6 | - |
| Epoxiconazole | 50 | 16.7 | - |
| Epoxiconazole | 100 | 48.7 | - |
| Epoxiconazole | 1000 | 53.2 | - |
| Picarbitrazox + epoxiconazole | 50+1 | 79.4 | 69.4 |
| Picarbitrazox + epoxiconazole | 10+1 | 73.4 | 53.4 |
| Picarbitrazox + epoxiconazole | 10+10 | 79.2 | 53.4 |
| Picarbitrazox + epoxiconazole | 1+25 | 70.1 | 50.4 |
| Picarbitrazox + epoxiconazole | 1+50 | 71.1 | 53.3 |
| Picarbitrazox + epoxiconazole | 1+100 | 71.3 | 71.3 |
| Picarbitrazox + epoxiconazole | 1+1000 | 73.5 | 73.7 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 50+1 | 0 | 5 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 10+1 | 0 | 0 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 10+10 | 0 | 0 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 1+25 | 8.7 | 11.6 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 1+50 | 13.4 | 16.7 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 1+100 | 44.9 | 48.7 |
| [ [6- [ [ [ [ (z) - (1-methyl-1H-tetrazol-5-yl) (phenyl) methylene ] group]Amino group]Oxy radical]Methyl radical]Pyridin-2-yl]Carbamic acid ester Pentyl ester + epoxiconazole | 1+1000 | 47.4 | 53.2 |
The above table clearly shows that the bactericidal composition according to the present invention has an actual efficacy against tomato blight higher than the calculated efficacy, i.e., has a significant synergistic effect, when the weight ratio of picarbrazox to epoxiconazole is in the range of 50:1 to 1: 50.
Test 2 downy mildew test (grape)/protective efficacy test
Solvent: 24.5 parts by weight of acetone
24.5 pbw of dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To obtain a suitable preparation of the active compound, 1 part by weight of active compound is mixed with an amount of solvent and emulsifier and the concentrate is diluted with water to the desired concentration.
To test for protective activity, young plants are sprayed with the preparation of active compound at a certain application rate. After the sprayed coating has dried, the plants are inoculated with an aqueous spore suspension of peronospora viticola. The plants were then placed in an incubator at about 20 ℃ and 100% relative atmospheric humidity.
The test results were evaluated 3 days after incubation. 0% indicates the drug effect corresponding to the control, and 100% indicates no disease.
The above table clearly shows that in the bactericidal composition according to the present invention, the actual efficacy against grape downy mildew is higher than the calculated efficacy when the weight ratio of picarbrazox to epoxiconazole is in the range of 50:1 to 1:50, i.e. there is a synergistic effect, and the synergistic effect is most significant.
Claims (13)
1. A germicidal composition, characterized by: the bactericidal composition comprises active ingredients of Picarbtrazox and epoxiconazole, wherein the weight ratio of Picarbtrazox to epoxiconazole is 50:1-1: 50.
2. The bactericidal composition of claim 1, wherein the weight ratio of picarbtrazox to epoxiconazole is from 25:1 to 1: 25.
3. The bactericidal composition of claim 1, wherein the weight ratio of picarbtrazox to epoxiconazole is 10:1 to 1: 10.
4. The bactericidal composition of claim 1, wherein the weight ratio of picarbrazox to epoxiconazole is 5:1 to 1: 5.
5. The germicidal composition of claim 1, wherein: the sum of the mass of the Picarbitrazox and the mass of the epoxiconazole accounts for 5-90% of the mass of the sterilizing composition.
6. The germicidal composition of claim 1, wherein: the sum of the mass of the Picarbitrazox and the mass of the epoxiconazole accounts for 10-80% of the mass of the sterilizing composition.
7. The germicidal composition of claim 1, wherein: the sum of the mass of the Picarbitrazox and the mass of the epoxiconazole accounts for 20-60% of the mass of the sterilizing composition.
8. The germicidal composition of claim 1, wherein: the dosage form of the bactericidal composition is suspending agent, seed coating agent, wettable powder, water dispersible granules, microcapsule suspending agent, coated granules, extruded granules, missible oil, microemulsion, emulsion in water, effervescent tablets, ultra-low volume liquid and suspoemulsion.
9. The germicidal composition of claim 1, wherein: also comprises a filler and/or a surfactant.
10. A method of controlling phytopathogenic fungi, characterized by: the method of treating a pathogen and/or its environment, or a plant, seed, soil, area, material or space with the germicidal composition of claim 1.
11. The method of claim 10, wherein: the Picarbitrazox and epoxiconazole according to claim 1 being administered simultaneously, or separately, or sequentially.
12. Use of the fungicidal composition according to claim 1 for controlling fungi.
13. Use of the fungicidal composition according to claim 1 for controlling fungi on cereals, fruits and vegetables.
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| CN100473278C (en) * | 2006-04-19 | 2009-04-01 | 江苏龙灯化学有限公司 | Bactericide composition with synergistic effect |
| CN100473277C (en) * | 2007-08-14 | 2009-04-01 | 江苏龙灯化学有限公司 | Synergistic sterilizing composition containing tricyclazole and tebuconazole |
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| CN102258057B (en) * | 2011-05-25 | 2013-07-24 | 江苏龙灯化学有限公司 | Sterilizing agent composition with synergizing action |
| CN103385256A (en) * | 2012-05-07 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Synergistic sterilization composition containing Xemium and triazoles |
| CN105076153B (en) * | 2014-05-08 | 2018-07-17 | 江苏龙灯化学有限公司 | A kind of plant disease control composition |
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| CN105076155B (en) * | 2014-05-08 | 2017-04-26 | 江苏龙灯化学有限公司 | Plant disease preventing and treating composition |
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