CN116139070A - Sleep-aiding cold compress gel and preparation method thereof - Google Patents

Sleep-aiding cold compress gel and preparation method thereof Download PDF

Info

Publication number
CN116139070A
CN116139070A CN202211664519.0A CN202211664519A CN116139070A CN 116139070 A CN116139070 A CN 116139070A CN 202211664519 A CN202211664519 A CN 202211664519A CN 116139070 A CN116139070 A CN 116139070A
Authority
CN
China
Prior art keywords
parts
sleep
aiding
cold compress
compress gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202211664519.0A
Other languages
Chinese (zh)
Inventor
童晓松
邹杰
邢旺兴
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hangzhou Jianlai Biotechnology Co ltd
Original Assignee
Hangzhou Jianlai Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Jianlai Biotechnology Co ltd filed Critical Hangzhou Jianlai Biotechnology Co ltd
Priority to CN202211664519.0A priority Critical patent/CN116139070A/en
Publication of CN116139070A publication Critical patent/CN116139070A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to sleep-aiding cold compress gel and a preparation method thereof, wherein the sleep-aiding cold compress gel comprises 0.5-5.0 parts of clozapine, 0.5-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN, 1.0-5.0 parts of gamma aminobutyric acid, 0.01-0.50 parts of plant essential oil, 0.1-1.0 parts of sodium carboxymethyl cellulose, 0.2-1.0 parts of carbomer 971, 0.2-1.0 parts of carbomer 980 and 70-90 parts of water. The sleep-aiding cold compress gel and the use method thereof are used for massaging 8 head and neck acupoints such as a sleep-aiding acupoint and a Baihui acupoint for 5-10 minutes about 1 hour before sleeping, so that the sleep-aiding effect is achieved.

Description

Sleep-aiding cold compress gel and preparation method thereof
Technical Field
The invention relates to the technical field of gel, in particular to sleep-aiding cold compress gel and a preparation method thereof.
Background
Good sleep is critical to maintaining physiological and mental health in humans, and insomnia is a type of disorder characterized by the frequent inability to achieve normal sleep. The traditional Chinese medicine is mainly characterized by difficulty in falling asleep or easiness in waking after falling asleep, insufficient sleep time caused by incapability of falling asleep after waking, and often incapability of obtaining normal sleep, and is a common disease mainly manifested in clinical manifestations of severe cases such as insomnia at night. Insomnia is a sub-health state with extremely high incidence rate in modern people, is often accompanied with symptoms such as headache, dizziness, amnesia, dysphoria and the like, and can affect normal work, study and life of people when serious, and is easy to induce or aggravate palpitation, shortness of breath, chest distress, dizziness, headache, listlessness, amnesia and the like. Insomnia is generally classified into stress type insomnia, anxiety type insomnia, depression type insomnia, bad preference type insomnia, drug type insomnia, physiological type insomnia, insomnia fear type and other disease type insomnia.
The traditional medicine for treating insomnia has traditional Chinese medicines and chemical medicines, and the most commonly used medicine can take effect quickly, and can directly block various external stimuli and impulses from being transmitted into the central nervous system of the brain, inhibit the central nervous system from inducing similar sleep fluctuation and promote people to fall asleep; however, the side effects are obvious, various discomforts such as headache, dizziness and nausea are easy to cause, and individual physique even presents symptoms such as excitement, multiple languages, illusion and the like, and the drug-induced insomnia is more serious. Furthermore, the long-term use of the medicine not only easily causes medicine dependence, but also causes various iatrogenic diseases such as liver, kidney, digestive tract function damage and the like.
Therefore, when a patient is insomnia, the traditional medicine has more or less side effects and adverse effects in the treatment process, and based on the traditional medicine, a brand new article for treating insomnia is designed, which is urgently needed in the current field.
Disclosure of Invention
Accordingly, the present invention is directed to a cold compress gel for aiding sleep and a preparation method thereof, which solve one of the above-mentioned drawbacks.
The invention is realized by the following two technical schemes:
one of the invention:
a cold compress gel for aiding sleep comprises 0.5-5.0 parts of clozapine, 0.5-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN, 1.0-5.0 parts of gamma aminobutyric acid, 0.01-0.50 parts of plant essential oil, 0.1-1.0 parts of sodium carboxymethyl cellulose, 0.2-1.0 parts of carbomer 971, 0.2-1.0 parts of carbomer 980 and 70-90 parts of water.
Further, the mass ratio of the clozapine to the promethazine is 0.50-5.0:0.50-5.0.
Further, the mass ratio of the clozapine to the melatonin is 0.50-5.0:1.0-5.0.
Further, the mass ratio of the clozapine to the NMN is 0.50-5.0:1.0-5.0.
Further, the mass ratio of the clozapine to the gamma-aminobutyric acid is 0.50-5.0:1.0-5.0.
Further, the mass ratio of the clozapine to the plant essential oil is 0.5.0-5.0:0.01-0.50.
Further, the cold compress gel also comprises 0.10-1.0 parts of ethanol.
Further, the cold compress gel also comprises 0.10-1.0 part of compound nipagin ester preservative.
Further, the cold compress gel also includes 0.20-1.0 parts carbomer 971 or carbomer 980.
The second invention is that:
the preparation method of the sleep-aiding cold compress gel comprises the following specific steps:
1) Adding 0.10-1.0 part of sodium carboxymethylcellulose, 0.20-1.0 part of carbomer 971 and 0.20-1.0 part of carbomer 980 into 70-90 parts of water, and stirring until the materials are uniformly mixed;
2) Adding 1.0-20.0 parts of glycerol and 0.10-1.0 parts of preservative, and stirring until the components are uniformly mixed;
3) Adding 0.50-5.0 parts of clozapine, 0.50-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN and 1.0-5.0 parts of gamma aminobutyric acid, and stirring until the components are uniformly mixed to form paste;
4) Adding 0.10-1.0 part of ethanol and 0.01-0.50 part of plant essential oil, stirring, and grinding by a grinder;
5) Vacuum packaging, and vacuum degassing to obtain cold compress gel.
The invention has the beneficial effects that:
the sleeping-aiding cold compress gel and the preparation method thereof are used for massaging 8 head and neck acupoints such as a sleeping acupoint and a Baihui acupoint for 5-10 minutes about 1 hour before sleeping, so that the sleeping-aiding effect is achieved.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objects and other advantages of the invention may be realized and obtained by means of the instrumentalities and combinations particularly pointed out in the specification.
Drawings
FIG. 1 is a schematic illustration of the location of a hypnotic cavity;
FIG. 2 is a schematic diagram of the location of Baihui points;
FIG. 3 is a schematic diagram of the location of the four smart points;
FIG. 4 is a schematic view of the location of the Yintang acupoint;
FIG. 5 is a schematic view of the location of the Shenting acupoint;
FIG. 6 is a schematic view of the location of a wind sump pit;
FIG. 7 is a schematic diagram of the location of the first-dimension acupoint;
fig. 8 is a schematic view of the location of a temple.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the foregoing description of the invention, it should be noted that the azimuth or positional relationship indicated by the terms "one side", "the other side", etc. are based on the azimuth or positional relationship shown in the drawings, or the azimuth or positional relationship in which the inventive product is conventionally put in use, are merely for convenience of describing the invention and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and therefore should not be construed as limiting the invention. Furthermore, the terms "first," "second," and the like, are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.
Furthermore, the terms "identical" and the like do not denote that the components are identical, but rather that there may be minor differences. The term "perpendicular" merely means that the positional relationship between the components is more perpendicular than "parallel" and does not mean that the structure must be perfectly perpendicular, but may be slightly tilted.
One of the present invention provides a technical scheme: a cold compress gel for improving sleep,
comprises 0.5-5.0 parts of clozapine, 0.5-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN, 1.0-5.0 parts of gamma aminobutyric acid, 0.01-0.50 parts of plant essential oil, 0.1-1.0 parts of sodium carboxymethyl cellulose, 0.2-1.0 parts of carbomer 971, 0.2-1.0 parts of carbomer 980 and 70-90 parts of water, wherein the sodium carboxymethyl cellulose is abbreviated as CMC-Na, has strong hygroscopicity, is easy to dissolve in water, and is a high-viscosity liquid when neutral or alkaline. The thixotropic property plays an important role in a gel system; not only is the emulsion stabilizer, the thickener, the flocculant, the chelating agent and the water-retaining agent good, but also the emulsion stabilizer has excellent anti-freezing stability, can improve the stability of products and prolongs the storage time.
In this embodiment: the mass ratio of the clozapine to the promethazine is 0.50-5.0:0.50-5.0.
In this embodiment: the mass ratio of the clozapine to the melatonin is 0.50-5.0:1.0-5.0.
In this embodiment: the mass ratio of clozapine to NMN is 0.50-5.0:1.0-5.0.
In this embodiment: the mass ratio of the clozapine to the gamma aminobutyric acid is 0.50-5.0:1.0-5.0.
In this embodiment: the mass ratio of the clozapine to the plant essential oil is 0.5.0-5.0:0.01-0.50.
In this embodiment: the cold compress gel also comprises 0.10-1.0 parts of ethanol.
In this embodiment: the cold compress gel also comprises 0.10-1.0 part of compound nipagin ester preservative.
In this embodiment: the cold compress gel also comprises 0.20-1.0 parts of carbomer 971 or carbomer 980, wherein carbomer (carbopol l) is a cross-linked polyacrylic resin and contains 56-68% of carboxylic acid groups in terms of dry product. The molecular weight of carbomer resin is theoretically estimated at 7X 10 5 Up to 4X 10 9 Between them. Carbomers have a certain affinity for the skin and can reduce irritation and damage to the skin and mucous membranes caused by irritant substances. Carbomers also contain a slightly acidic substance, maintain metabolism of the body, and effectively reduce ultraviolet damage to the skin. The super absorbent resin is often used as hydrogel raw materials, and carbomers 934, 940,941, 980, 971, 974P,934P,1342, 2020 and the like are commonly used, so that the super absorbent resin has the characteristics of instant dissolution, electrolyte resistance, acid resistance and the like, plays roles of reducing viscosity, diminishing inflammation, sterilizing, protecting skin and the like, and has the functions of water retention, thickening, emulsifying agent and the like.
Carbomer 971 is carbomer containing low residual ethyl acetate, and is commonly used for transparent gel products containing ethanol, transparent skin care gel, hair styling gel and the like, and the recommended dosage is as follows: 0.2-1.0%, carbomer 980 has good thickening property, high transparency, high viscosity and strong suspending capability. The recommended dosage is used for crystallizing clear gel, transparent gel products containing ethanol, transparent skin care gel, hair styling gel and the like: 0.2-1.0%. Carbomer 980 has a larger polymer molecule than 971, and under different conditions of concentration, temperature, pH, etc., the viscosity and rheology of each polymer are different, and the ionic resistance and shear resistance of each polymer are different. Carbomer 971 has better permeability and lower viscosity than 980, but is only suitable for concentrations below 65% above which gel whitening directly affects appearance. 980 and 940 have little effect on transparency when ions are present or concentration is increased, but 980 has a higher resistance to ions than 940, so 980 provides relatively higher viscosity and yield values when ions are increased. Carbomer 980 has slight elasticity and moisturized and smooth skin feel when initially applied, is suitable for a moderate or biased-feel thick formula, and is not sticky after use; carbomer 971 gives a clearer skin feel and is suitable for a refreshing formula. Carbomer 971 is important as a rheology modifier, while carbomer 980 is important as a thickener.
The parts mentioned in this example are calculated at 1 part to 100 g.
The second invention is that:
the preparation method of the sleep-aiding cold compress gel comprises the following specific steps:
1) Adding 0.10-1.0 part of sodium carboxymethylcellulose, 0.20-1.0 part of carbomer 971 and 0.20-1.0 part of carbomer 980 into 70-90 parts of water, and stirring until the materials are uniformly mixed;
2) Adding 1.0-20.0 parts of glycerol and 0.10-1.0 parts of preservative, stirring until the components are uniformly mixed, wherein the glycerol contains three hydroxyl groups, has the capacity of forming hydrogen bonds with water molecules, is extremely easy to dissolve in water, has hygroscopicity and is a good humectant.
Glycerol is added into the hydrogel to be mainly used as a moisturizing agent of cosmetics, so that the moisture can be kept and the texture of the gel can be enhanced;
the existence of the glycerol can enable the hydrogel cosmetic with high water content to be smeared on skin, has good moisture retention and skin moisturizing properties, and can prevent gel from quick drying or freezing especially in a dry environment;
3) Adding 0.50-5.0 parts of clozapine, 0.50-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN and 1.0-5.0 parts of gamma aminobutyric acid, and stirring until the components are uniformly mixed to form paste;
4) Adding 0.10-1.0 part of ethanol and 0.01-0.50 part of plant essential oil, stirring, and grinding by a grinder;
5) Vacuum packaging, and vacuum degassing to obtain cold compress gel.
Long-term clinical practice has shown that clozapine is a safe, well-tolerated and effective antipsychotic. Nonetheless, clozapine needs improvement. In particular, improvements in terms of reduced side effects are needed. For clozapine, these side effects mainly include excessive sedation, weight gain, excessive saliva, heart rhythm disturbances, orthostatic hypotension and fever, etc. The first 3 most common occur most often at the beginning of the treatment.
It is further clear that there is a need for further enhancing some of its beneficial effects on sleep.
The invention can completely avoid certain potential safety hazard existing in sedative-hypnotic drugs for treating insomnia at present. The promethazine can strengthen the effects of anesthetics, hypnotics and analgesics, is combined with small dosage of clozapine, is combined with NMN, gamma aminobutyric acid, melatonin and the like, combines the theoretical basis of traditional Chinese medicine, combines the tranquilizing and allaying excitement, and pressure-relieving and sleep-aiding functions of essential oil, applies massage on specific sleep-aiding acupuncture points of the head through cold compress, and synergistically improves the sleep quality, thereby not only playing a role in multiple sleep aiding, but also reducing the side effects of clozapine and promethazine to the greatest extent, strengthening the sleep-aiding efficacy, and achieving safety, effectiveness and good tolerance.
Promethazine hydrochloride (phenazome) can block H of smooth muscle, capillary vessel wall and other tissues 1 The receptor has competitive antagonism with histamine, can obviously stabilize the center, and can strengthen the functions of anesthetics, hypnotics and analgesics. And can reduce body temperature and relieve vomiting. Can be used for treating various allergies (such as asthma, urticaria, etc.), and dizziness caused by pregnancy emesis and boarding; can be combined with aminophylline, etcThe asthma is treated by combination; and mixing with pethidine to obtain hibernation injection for artificial hibernation.
Melatonin (Melatonin): is an amine hormone produced mainly by pine cones of mammals and humans. Has multiple physiological functions of promoting sleep, regulating time difference, resisting aging, regulating immunity, resisting tumor, etc. The melanin-fading can improve sleep, shorten the pre-sleep wake time and the sleep-on time, improve the sleep quality, obviously reduce the number of wake-on times in sleep, shorten the shallow sleep stage, prolong the deep sleep stage and reduce the wake-on threshold in the next morning. Has stronger time difference adjusting function. Melatonin is a novel hypnotic drug, and has the unique advantages that: the small dosage (1-3 mg) has more ideal hypnotic effect; is an endogenous substance and can not accumulate in the body; the biological half-life is short, and the biological half-life is reduced to the physiological level of normal people after being orally taken for several hours; the toxicity is very small. However, a person can fall asleep only by 0.03 mg of melatonin, and most sleep-aiding drugs contain melatonin in an amount of up to 3mg or even 9 mg, which can cause the person to feel dizziness after getting up the next morning.
The existing multiple melatonin health-care products are good in primary insomnia effect and poor in insomnia effect caused by other problems by orally supplementing melatonin missing from the body; therefore, an ultra-large dose is often used to obtain good curative effect, but forced change of hormone level of human body can further cause endocrine dyscrasia, reduce secretion of sex hormone and risk sterility for men and women. Melatonin is also the leading cause of winter depression. In the invention, the melatonin with very small dosage is used for external application to assist NMN, gamma aminobutyric acid and plant essential oil to guide sleep, thus the effects of helping sleep and safety can be obtained, and no side effect can be generated after long-term use.
Beta-nicotinamide mononucleotide (Nicotinamide mononucleotide, NMN): belongs to vitamin B group derivatives, and is a naturally occurring bioactive nucleotide; NMN is a direct precursor of nicotinamide adenine dinucleotide (coenzyme i, nad+) which is an essential molecule in human body, is considered to be a key component for increasing intracellular nad+ level, and exists in each cell, and is widely involved in various biochemical reactions of human body and is closely related to immunity and metabolism. The decline in nad+ during aging is believed to be a major cause of diseases and disabilities, such as hearing and vision loss, cognitive and motor dysfunction, immunodeficiency, arthritis caused by autoimmune inflammatory response disorders, metabolic disorders, and cardiovascular diseases. NMN function is manifested by nad+, and is considered a supplement to prevent aging and restore younger age; the NMN supplementation can increase the NAD+ content in the body, thereby delaying, improving and preventing various phenotypes related to aging, age-induced metabolic disorders, senile diseases and the like. NMN is used for middle-aged and elderly people, and can relieve or alleviate various sub-health problems such as chronic fatigue, poor sleep, vision deterioration, etc.; the invention uses small dose NMN for external use to assist the sleep of clozapine, promethazine, gamma aminobutyric acid, melatonin and plant essential oil, can obtain the effects of sleep assistance and safety, and does not generate any side effect after long-term use.
Gamma-aminobutyric acid (4-aminobutyric acid, gamma-aminobutyr ic ac id, GABA for short), which is an amino acid widely existing in vertebrates, plants and microorganisms, is an important central nervous system inhibitory neurotransmitter, and about 50% of synaptic sites take GABA as a medium, and has various physiological functions of activating glucose metabolism in brain, promoting acetylcholine synthesis, reducing blood ammonia, anticonvulsant, lowering blood pressure, improving brain functions, improving lipid metabolism, neuroleptic effect, promoting growth hormone secretion and the like.
Research shows that when GABA in a human body is absent, the emotion such as anxiety, tiredness, anxiety and the like can be generated, people in a high-pressure group such as a body competition environment, athletes, office workers and the like can easily lack GABA, and the intake of a certain amount of GABA has the effects of improving the sleeping quality of the organism, reducing blood pressure and the like.
Plant essential oils are produced by the tiny glands of various parts of the plant (e.g., roots, stems, leaves, etc.). Contains terpenes and other compounds and organic acid, can be naturally volatilized, is dissolved in alcohol, vegetable oil and water, is not greasy and greasy, and can not leave oil stains on skin. Essential oils are classified into 6 kinds of flavors, medicines, aromatherapy, etc. according to the uses.
The essential oil has unique fragrance, can play a role in stabilizing tension emotion, resisting anxiety, resisting depression and relieving psychological stress, and has the function of controlling emotion stabilization, so that the essential oil is used for tranquilizing and allaying excitement, helping sleep and improving sleep quality.
The essential oils on the market at present are various and are helpful for sleeping, mainly lavender essential oil, sweet orange essential oil, chamomile essential oil, sandalwood essential oil, vetiver essential oil, lemon essential oil, bergamot essential oil, ylang essential oil, angline essential oil, rose essential oil, jasmine essential oil and the like; common methods of essential oil for promoting sleep include fragrance-expanding method, sniffing method, massage method, direct wiping method, bathing method, foot bathing method, etc., and the primary sleep disorder begins by selecting favorite fragrance. The internal balance is regulated by fumigating or applying temple, back neck, vertebra and sole. For people with mild sleep disorder, single essential oil, or medium and severe sleep disorder can be used, and 2 to 3 essential oil combinations can be selected. The lavender essential oil has the most remarkable curative effect of helping sleep, so that the lavender essential oil can be used for relieving symptoms and improving sleep quality for people with insomnia and sleep quality reduction.
The lavender essential oil is extracted from Lavandula angustifolia, has the best quality, and has the functions of clearing heat and detoxicating, resisting bacteria and removing freckles, removing wrinkles and whitening, removing pouch dark circles, calming and reducing pressure, reducing depression and aiding sleep, relaxing body and mind, and the like. Has effects in caring skin, relieving pressure, and relaxing muscles. Often, 1-2 drops of lavender essential oil are dropped on cotton balls and placed in or beside a pillow, or 4 drops of lavender essential oil are aromatherapy to treat insomnia and enable your laugh to sleep. For those with heavy insomnia, the herbal composition can be combined with marjoram (Lavender: marjoram=4:1) to enhance sedative and sleep-aiding effects. 2-3 kinds of single essential oil (mainly comprising lavender, chamomile, sandalwood, marjoram, rosemary, valerian, bergamot, sweet orange, pear wood, ylang, vetiver, lemon, angxila, rose and jasmine) with total amount of 3 drops can be diluted into 3-4 ml of plant massage oil for assisting sleep by face, head, neck and shoulder or body massage.
Roman chamomile is a small perennial herb, about 25cm in height, hair in the stem, feathered and soft leaves, and white in color. The roman chamomile essential oil has a sweet smell and a somewhat apple-like smell. The color is light green and clear, and the adhesive has water quality. The main chemical components are terpinene or pinene, camphene, sabinene, myrcene, eucalyptol, terpinene, and caryophyllene. Can relax anxiety, tension, anger and fear, and relax tolerance and feel peaceful. The anxiety is relieved, the mind is calm, and the health care tea is helpful for insomnia. The chamomile can strengthen the sedative effect of lavender; can be used as a substitute of lavender, and can improve sleep by mixed use of massage or bath, and is especially suitable for people who rely on medicines to sleep, preferably, the same essential oil is not needed to be used for 3 to 4 weeks continuously, and the essential oil can be used for stopping and changing periodically.
The acupoint massage and sleep aiding are based on the external treatment of traditional Chinese medicine and the theory of acupoints and channels, and the frequent insomnia treatment is based on the governor meridian, the hand shaoyin and the foot taiyin channels. Can massage the special effect acupoints of Shenmen, neiguan, hypnotic, sanyinjiao and Baihui for treating insomnia, and can also select Sishen Tong, yintang, zhaohai and Shenmai. The new syndrome differentiation system is creatively applied for the first time, the cold compress hydrogel is prepared by applying the modern technology, and relevant acupoints of the head and the neck are independently selected to massage and help sleep, promote sleep health and obtain good effects. The positions, effects and efficacy of the above-mentioned acupoints are described as follows, except that the massage and hypnotic acupoints and Baihui acupoints are selected as main acupoints, the four Shen Tong acupoints and Yintang acupoint are selected as auxiliary acupoints, and the Shenting acupoint and Fengchi acupoint are newly added as main acupoints, and the first Wei acupoint and Taiyang acupoint are selected as auxiliary acupoints.
1. Sleep-promoting acupoint
As shown in FIG. 1, the "Yi-Gao-Nao" is also called an insomnia point, which is located at the midpoint of the line between the side of the neck, the Yi Feng point (in the depression behind the ear) and the Yi Xue point (in the depression under the occipital bone), and on the left and right sides. Has effects of tranquilizing, suppressing hyperactive liver, calming endogenous wind, tranquilizing, and can be used for treating insomnia, giddiness, headache, tinnitus, amnesia, palpitation, mania, etc. Modern medicine is often used to treat neurasthenia, insomnia, hysteria, psychosis, etc. The four gods, the wind pool and the sun are matched for mainly treating headache and dizziness; the preparation is mainly used for treating insomnia; when the opposite side is rolled and is difficult to fall asleep, the finger tips of the middle fingers of the two hands are rubbed for 2 minutes, so that eyes can feel slightly sour and astringent, calm and aid sleep, and the sleep quality is improved.
2. Baihui acupoint
As shown in FIG. 2, baihui acupoint is also called Sanyang Wuhui, tianman, and Tianmountain. It is first seen in the "Jia Yi Jing" of acupuncture and moxibustion, pertaining to the governor vessel. Is positioned at the intersection point of the midline of the head top of the human body and the connecting line of the two earpoints. The Bai Hui is the intersection point of the governor meridian and the bladder meridian of foot, the Bai Hui Cong and Bai Bing Zhi have the functions of improving yang qi, inducing resuscitation and tranquillizing and stabilizing mind, and are the first choice point for treating various diseases such as headache. Is mainly used for treating dizziness, headache, hemorrhoid, hypertension, hypotension, hangover, dizziness, insomnia, and dysphoria caused by deficiency of qi and blood, exuberance of liver fire and invasion of pathogenic wind. The Baihui acupoint can be respectively massaged for 3-5 minutes in the clockwise and anticlockwise directions before sleeping, and the insomnia can be automatically treated for 1-2 times per day.
3. Four-god smart acupoint
As shown in FIG. 3, the four Shen-Smart points are Jing-Xie-Ching points, also called Shen-Ching points, which are first seen in Yinhai Ji Ming, are located at the top of the head of the body, and are located at 1 cun positions on the front, back, left and right sides of Baihui points, and are composed of 4 points in total, so that the four Shen-Ching points are just like the four-way Shen-Ching points. Has effects of tranquilizing, removing head, improving eyesight, and inducing resuscitation. Can be used for treating insomnia, headache, dizziness, amnesia, epilepsy, psychosis, cerebrovascular disease sequela, cerebral hypoplasia, and eye diseases due to malnutrition of brain. The common health care method can be used for pressing the four Shen-clever with the tip of the index finger 100-200 times, and the insomnia is usually treated by being matched with Shenmen acupoint and Sanyinjiao acupoint.
4. Indonesia acupoint
As shown in fig. 4, the Indonesia is subordinate to the Jing external qi point. It is indicated for the "Yulong Jing" by acupuncture and moxibustion with magpie and god. Is the region where the three meridians of yang qi, blood qi and yin qi collect, and one acupoint on the governor vessel of the human body is located at the forehead and at the intersection point of the connecting line between the two eyebrows and the anterior midline. Has effects of relieving stuffy nose, inducing resuscitation, refreshing brain, improving eyesight, and tranquilizing mind. Is used for treating headache, dizziness, insomnia, conjunctivitis, blepharitis, rhinitis, frontal sinusitis, epistaxis, facial paralysis, trigeminal neuralgia, eclampsia, hypertension, mental debilitation, infantile convulsion, etc. The mind-tranquillizing and nerve-soothing people who generally feel tired easily turn red, often means that sleep is problematic, can "open the cochinchinese" to calm the mind and tranquilize the mind by rubbing and pressing the Yintang acupoint for 3-5 minutes every night before sleeping, and has better effects of locally having sour and distending feeling and matching with the various acupoints such as the Baihui, the Touwei and the Shenting.
5. Shenting acupoint
As shown in FIG. 5, shenting acupoint, the alias hairline, is called "Jiujia Yijing". Is positioned at the head of the human body, 0.5 cun directly above the middle of the current hairline. Is the intersection of the bladder meridian of foot taiyang, stomach meridian of foot yangming and governor vessel. Has effects of clearing head, dispelling pathogenic wind, tranquilizing, and relieving headache, insomnia, palpitation, dizziness, nasal obstruction, epistaxis, lacrimation, conjunctival congestion, conjunctivitis, epilepsy, hypomnesis, and schizophrenia. Most young people may suffer from insomnia, and Shenting acupoint is matched with Xinshu, taixi and Anmian to benefit heart and calm mind and improve insomnia. Is matched with Taichong, yin and Fengchi to relieve insomnia caused by hyperactivity of liver-yang. The acupoints are rubbed with the tips of the middle fingers of the two hands or the acupoints are pinched with the tips of the nails during massage, the strength is moderate, and the massage is performed for 3 to 5 minutes and 100 times every time.
6. Air pool hole
As shown in FIG. 6, the Fengchi acupoint is the gallbladder meridian of foot shaoyang. The posterior aspect of the occipital muscle is located in the depression on the neck, below the occipital bone, and on the level with the Fengfu acupoint, in the depression between the sternocleidomastoid muscle and the upper end of trapezius muscle. The meridian gallbladder channel qi and blood absorbs heat and becomes yang-heat wind qi, which has the functions of strengthening yang and tonifying qi; treating headache, dizziness, neck pain, conjunctival congestion, lacrimation, nasosinusitis, epistaxis, deafness, qi-closure, apoplexy, facial distortion, malaria, fever, common cold, goiter, stiff neck, etc., and relieving dizziness, asthenopia, neck pain, insomnia, hangover, etc. At present, many people have poor sleep quality due to tension and the like, and can relax mood by massaging and massaging the Fengchi acupoint, thereby being beneficial to sleeping. The rib surface of two fingers is tightly pressed against the acupoint of Fengchi, and then the finger is pressed and kneaded with force for several times, then after the brain is kneaded with pressure, the finger is made for about 30 times, so that it is favourable for that it has acid swelling feeling, and said invented method can be effectively used for tranquillizing and hypnotizing.
7. Head-vitamin acupoint
As shown in fig. 7, the first-dimension acupoint, the pelteobagrus fulvidraco acupoint, is referred to as the pelteobagrus fulvidraco acupoint. The "Jiujiuyi Jing" is located 0.5 cun above the hairline at the forehead and 4.5 cun beside the midline of the head. Is the point where the stomach meridian of foot yang is intersected with the gallbladder meridian of foot shaoyang and the yang-maintaining pulse. Has effects of dispelling pathogenic wind, clearing pathogenic fire, relieving pain, and improving eyesight for headache due to cold and heat, ocular pain, excessive lacrimation, dyspnea, vexation, emesis, sweating, eyelid movement, facial striae disappearance, lacrimation, and visual confusion. The main indications are: migraine, forehead neuralgia, vascular headache, schizophrenia, facial paralysis; apoplexy sequelae, hypertension; conjunctivitis, vision loss, etc. Because the head-vitamin acupoint is positioned at the lateral head, the head-vitamin acupoint can treat migraine, especially local migraine and lateral pain caused by overstress, fatigue or long-time insomnia, and the effect is better by adopting the methods of massaging, pressing or needling.
8. Temple
As shown in fig. 8, temple aliases: qianliang, qian, yuan Zheng, extra-Qi, and Ji Zhi Yin Hai Ji. Is positioned at the concave part of the back transverse finger between the eyebrow tip and the outer canthus. In front of auricle, on both sides of forehead and above the extension line of external canthus. Massage can relieve fatigue, excite spirit, relieve pain, refresh mind, and keep concentration. Has effects of removing liver fire for improving eyesight, dredging collaterals, relieving pain, and relieving conjunctival congestion, migraine, neurovascular headache, trigeminal neuralgia, toothache, eye fatigue, etc. When the massage is performed, the left and right temple are pressed by the two thumbs and the abdomen, and the massage is performed slightly forcefully and forcefully for 16 times in the clockwise direction and the anticlockwise direction. Then pressing the temple with the middle finger for about 0.5 minutes, and eliminating dark circles caused by insufficient sleep for a long time.
The invention uses promethazine to strengthen the effects of anesthetics, hypnotics and analgesics, uses small doses of clozapine in combination, combines with NMN, gamma aminobutyric acid, melatonin and the like, combines the theoretical basis of traditional Chinese medicine, combines the tranquilizing and allaying excitement and pressure-relieving sleep-aiding effects of essential oil, applies massage on sleep-aiding acupuncture points of the head in cold compress, synergistically improves the sleep quality, can play a role in multiple sleep-aiding, can furthest reduce the side effects of clozapine and promethazine, strengthens the sleep-aiding effect, combines multiple components for use, combines multiple methods of aromatic essential oil, traditional Chinese medicine acupuncture point massage and the like for use in cooperation, and has unexpected technical effects; the method is safe and effective and has good tolerance. Can completely avoid certain potential safety hazards existing in sedative-hypnotic drugs for treating insomnia at present.
The above as well as additional features, aspects, and advantages of the present application will become more readily apparent with reference to the following detailed description.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. It will be apparent that the described embodiments are some, but not all, embodiments of the invention. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present invention fall within the protection scope of the present invention.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The terms "first," "second," and the like in the description and in the claims, are not used for any order, quantity, or importance, but are used for distinguishing between different elements. Likewise, the terms "a" or "an" and the like do not denote a limitation of quantity, but rather denote the presence of at least one.
Preparation of cold compress gel 1:
adding 0.10 part of sodium carboxymethyl cellulose, 0.20 part of carbomer 971 and 0.80 part of carbomer 980 into 67.25 parts of water, and stirring at a high speed until the materials are uniformly mixed;
adding 20.0 parts of glycerol and 0.15 part of compound ethylparaben preservative (0.05 ethylparaben and 0.15 propylparaben), and stirring at high speed until the mixture is uniform;
adding 0.50 part of clozapine, 3.00 parts of promethazine, 3.00 parts of melatonin, 3.00 parts of NMN and 1.0 part of gamma aminobutyric acid, and stirring at a high speed until the components are uniformly mixed to form paste;
adding 0.60 part of ethanol and 0.40 part of plant essential oil, stirring, and grinding by a grinder;
vacuumizing and degassing;
packaging to obtain cold compress gel.
Preparation of cold compress gel 2:
adding 0.40 parts of sodium carboxymethyl cellulose, 0.40 parts of carbomer 971 and 0.40 parts of carbomer 980 into 79.05 parts of water, and stirring at a high speed until the components are uniformly mixed;
adding 10.0 parts of glycerol and 0.15 part of compound ethylparaben preservative (0.10 ethylparaben and 0.10 propylparaben), and stirring at high speed until the mixture is uniform;
adding 1.50 parts of clozapine, 1.50 parts of promethazine, 2.00 parts of melatonin, 2.00 parts of NMN and 2.00 parts of gamma aminobutyric acid, and stirring at a high speed until the components are uniformly mixed to form a paste;
adding 0.40 part of ethanol and 0.20 part of plant essential oil, stirring, and grinding by a grinder;
vacuumizing and degassing;
packaging to obtain cold compress gel.
Preparation of cold compress gel 3:
adding 0.80 part of sodium carboxymethyl cellulose, 0.80 part of carbomer 971 and 0.20 part of carbomer 980 into 84.45 parts of water, and stirring at a high speed until the components are uniformly mixed;
adding 5.0 parts of glycerol and 0.15 part of compound ethylparaben preservative (0.15 part of ethylparaben and 0.05 part of propylparaben), and stirring at high speed until the mixture is uniform;
adding 3.00 parts of clozapine, 0.50 part of promethazine, 1.00 parts of melatonin, 1.00 parts of NMN and 3.00 parts of gamma aminobutyric acid, and stirring at a high speed until the components are uniformly mixed to form paste;
adding 0.20 part of ethanol and 0.10 part of plant essential oil, stirring, and grinding by a grinder;
vacuumizing and degassing;
packaging to obtain cold compress gel.
Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered by the scope of the claims of the present invention.

Claims (10)

1. A sleep-aiding cold compress gel is characterized in that:
comprises 0.5-5.0 parts of clozapine, 0.5-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN, 1.0-5.0 parts of gamma aminobutyric acid, 0.01-0.50 parts of plant essential oil, 0.1-1.0 parts of sodium carboxymethyl cellulose, 0.2-1.0 parts of carbomer 971, 0.2-1.0 parts of carbomer 980 and 70-90 parts of water.
2. A sleep-aiding cold compress gel according to claim 1, wherein: the mass ratio of the clozapine to the promethazine is 0.50-5.0:0.50-5.0.
3. A sleep-aiding cold compress gel according to claim 1, wherein: the mass ratio of the clozapine to the melatonin is 0.50-5.0:1.0-5.0.
4. A sleep-aiding cold compress gel according to claim 1, wherein: the mass ratio of the clozapine to the NMN is 0.50-5.0:1.0-5.0.
5. A sleep-aiding cold compress gel according to claim 1, wherein: the mass ratio of the clozapine to the gamma-aminobutyric acid is 0.50-5.0:1.0-5.0.
6. A sleep-aiding cold compress gel according to claim 1, wherein: the mass ratio of the clozapine to the plant essential oil is 0.5.0-5.0:0.01-0.50.
7. A sleep-aiding cold compress gel according to claim 1, wherein: the cold compress gel also comprises 0.10-1.0 parts of ethanol.
8. A sleep-aiding cold compress gel according to claim 1, wherein: the cold compress gel also comprises 0.10-1.0 part of compound nipagin ester preservative.
9. A sleep-aiding cold compress gel according to claim 1, wherein: the cold compress gel also includes 0.20-1.0 parts carbomer 971 or carbomer 980.
10. The method for preparing the sleep-aiding cold compress gel according to any one of claims 1 to 9, wherein the specific steps are as follows:
1) Adding 0.10-1.0 part of sodium carboxymethylcellulose, 0.20-1.0 part of carbomer 971 and 0.20-1.0 part of carbomer 980 into 70-90 parts of water, and stirring until the materials are uniformly mixed;
2) Adding 1.0-20.0 parts of glycerol and 0.10-1.0 parts of preservative, and stirring until the components are uniformly mixed;
3) Adding 0.50-5.0 parts of clozapine, 0.50-5.0 parts of promethazine, 1.0-5.0 parts of melatonin, 1.0-5.0 parts of NMN and 1.0-5.0 parts of gamma aminobutyric acid, and stirring until the components are uniformly mixed to form paste;
4) Adding 0.10-1.0 part of ethanol and 0.01-0.50 part of plant essential oil, stirring, and grinding by a grinder;
5) Vacuum packaging, and vacuum degassing to obtain cold compress gel.
CN202211664519.0A 2022-12-23 2022-12-23 Sleep-aiding cold compress gel and preparation method thereof Pending CN116139070A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211664519.0A CN116139070A (en) 2022-12-23 2022-12-23 Sleep-aiding cold compress gel and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202211664519.0A CN116139070A (en) 2022-12-23 2022-12-23 Sleep-aiding cold compress gel and preparation method thereof

Publications (1)

Publication Number Publication Date
CN116139070A true CN116139070A (en) 2023-05-23

Family

ID=86357476

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202211664519.0A Pending CN116139070A (en) 2022-12-23 2022-12-23 Sleep-aiding cold compress gel and preparation method thereof

Country Status (1)

Country Link
CN (1) CN116139070A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1623598A (en) * 2004-06-29 2005-06-08 陈瑞真 Volatile extraction for promoting falling asleep and improving sleep quality and its product for external use
CN105770482A (en) * 2016-05-26 2016-07-20 佛山市朗达信息科技有限公司 External composition with sleep improvement function and preparation method thereof
CN111053735A (en) * 2020-02-25 2020-04-24 上海阶平医院管理有限公司 Cold compress gel for treating insomnia
US20200253858A1 (en) * 2019-02-08 2020-08-13 Amorepacific Corporation Cosmetic composition comprising citron oil bead
CN112057567A (en) * 2020-09-30 2020-12-11 洛阳新坐标生物工程有限公司 Formula and preparation method of patch for treating insomnia
CN113262260A (en) * 2021-06-05 2021-08-17 亳州益智健康产业有限公司 Cold compress gel for treating insomnia

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1623598A (en) * 2004-06-29 2005-06-08 陈瑞真 Volatile extraction for promoting falling asleep and improving sleep quality and its product for external use
CN105770482A (en) * 2016-05-26 2016-07-20 佛山市朗达信息科技有限公司 External composition with sleep improvement function and preparation method thereof
US20200253858A1 (en) * 2019-02-08 2020-08-13 Amorepacific Corporation Cosmetic composition comprising citron oil bead
CN111053735A (en) * 2020-02-25 2020-04-24 上海阶平医院管理有限公司 Cold compress gel for treating insomnia
CN112057567A (en) * 2020-09-30 2020-12-11 洛阳新坐标生物工程有限公司 Formula and preparation method of patch for treating insomnia
CN113262260A (en) * 2021-06-05 2021-08-17 亳州益智健康产业有限公司 Cold compress gel for treating insomnia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NIAS营养学国际研修项目组编著: "《NuCalm压力管理系统》", vol. 1, 31 December 2020, 湖北科学技术出版社, pages: 50 *
钱之玉等: "《药理学进展》", vol. 1, 31 May 2005, 东南大学出版社, pages: 14 *

Similar Documents

Publication Publication Date Title
CN105769685A (en) Mild moisture-retention cleansing water and preparation method thereof
KR101908978B1 (en) A aromatic composition having anti-stress and fatigue relaxing, and a cosmetic composition containing the same
CN104800430A (en) Essential oil for improving depth of sleep
CN105687520A (en) Hair nurturing liquid for inhibiting hair loss and white hair and promoting hair growth and preparation method
CN110655990A (en) Preparation method and application of traditional Chinese medicine wormwood essential oil
CN104323961A (en) Whitening and spot-removing traditional Chinese medicine facial mask and preparation method thereof
CN102864063A (en) Pepper health protection wine and preparation method thereof
CN111195333A (en) Composition and sleep cream for improving sleep, and preparation method and use method thereof
CN105998460A (en) Composition with efficacies of eliminating sleepiness as well as refreshing mind and preparation method of composition
CN103520435B (en) Agilawood health care essential oil
CN108175806A (en) A kind of Chinese medicine eye paste and preparation method thereof
CN109432174A (en) One kind relieving pain compound essential oil and the preparation method and application thereof
CN116139070A (en) Sleep-aiding cold compress gel and preparation method thereof
CN111568827A (en) Moisturizing and makeup removing mousse
KR102455783B1 (en) Natural essential oil composition with excellent sleep effect and Cosmetic composition comprising the same
CN104689292A (en) Compound essential oil with refreshing effect and sterilization and disinfection effect
KR20180083782A (en) Cosmetic composition comprising withania somnifera, morus australis and pure tea extracts
CN112870143A (en) Traditional Chinese medicine mask for nourishing yin and promoting blood circulation and preparation method thereof
CN115350260B (en) Daily care biological agent with sleep-aiding function for skin and preparation method thereof
CN101721486A (en) Eye guard for treating insomnia and preparation method thereof
CN113694001A (en) Traditional Chinese medicine mask paste
CN111184652A (en) Pure natural skin-nourishing essential oil
CN110269926A (en) Middle benefit gas, which is relaxed, warms up composition and its preparation method and application
CN108079059A (en) A kind of styrax compound essential oil for improvement sleep
CN115414285B (en) Chest care essential oil and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination