CN113262260A - Cold compress gel for treating insomnia - Google Patents

Abstract

The invention discloses a cold compress gel for treating insomnia, which is prepared from traditional Chinese medicine extract, melatonin, mirtazapine, poloxamer and water; wherein, the traditional Chinese medicine extract is prepared by extracting the following raw materials: semen Ziziphi Spinosae, fructus Jujubae, semen plantaginis, radix Angelicae sinensis, Ginseng radix, Glycyrrhrizae radix, radix Platycodi, flos Albizziae, rhizoma Acori Calami and cortex et radix Polygalae; the perfect combination of the traditional Chinese medicine and the western medicine is realized by utilizing the synergistic and complementary action of the traditional Chinese medicine and the western medicine, the defects of great side effect and dependency generation of the western medicine are overcome, the problem of slow response of the traditional Chinese medicine is solved, the side effect is relieved while the insomnia symptom is relieved, the drug dependency is reduced, the burden of the liver and the kidney is relieved, and the requirements of modern people on the insomnia medicine in the aspects of curative effect, side effect, health and the like are met.

Description

Cold compress gel for treating insomnia

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a cold compress gel for treating insomnia.

Background

Insomnia is a type of condition characterized by the frequent inability to attain normal sleep. It is mainly manifested as difficulty in falling asleep, low depth of sleep, waking up when asleep, sleeping without snoring, no longer sleeping after waking up or sleepless all night. These manifestations ultimately lead to insufficient sleep time, failure to eliminate fatigue, and failure to restore physical and energy to the body. In the long run, it often obstructs the normal life, work, study and health of people, and can induce or aggravate palpitation, shortness of breath, chest distress, dizziness, headache, mental fatigue, amnesia, etc. Severe patients may develop symptoms such as increased heart rate, increased body temperature, and peripheral vasoconstriction. Insomnia is easy to cause fatigue, increase the disease probability, easily cause obesity, damage the appearance, destroy the emotion and cause rapid aging; and generally classified into stress type insomnia, anxiety type insomnia, depression type insomnia, bad taste type insomnia, drug type insomnia, physiological type insomnia, insomnia fear type and other disease type insomnia.

The existing methods for treating insomnia or treating insomnia in a nominal mode comprise the following steps: the sleeping western medicine can directly block various external stimuli and impulses from being transmitted to the nerve centre of the brain, and inhibit the nerve centre from causing similar sleep fluctuation to promote people to fall asleep; but has great side effects, causes headache, dizziness and nausea discomfort after long-term use, and has unstable safety. Most insomnia people are caused by mental problems such as anxiety, depression, dysphoria and the like, 15 percent of the insomnia people are caused by coronary heart disease and other medicinal components, the real primary insomnia accounts for only 15 percent of the insomnia people, and the insomnia treatment is absolutely not a problem which can be solved by a plurality of hypnotics. The sedative western medicine is sedative and calm, has the same property with the hypnotic western medicine, has different degrees, and has more stable sedative effect relative to the hypnotic medicine; however, the individual constitutions show symptoms such as excitement, multilingual sensation and hallucinations, and even more serious insomnia with drugs. Melatonin health care products supplement melatonin lacking in the body by oral administration, and can promote the generation of sleep for primary insomnia and frequent pace; but has obvious effect on treating insomnia caused by other problems except primary insomnia. Forcibly changing the hormone level of the human body, further causing endocrine dyscrasia, reducing the secretion of sex hormones, and having the risk of male and female infertility. Melatonin is also the chief culprit for winter melancholia. Compared with western medicines, the sedative traditional Chinese medicine has no dependence or addiction, can have a good improvement effect on long-term insomnia and poor sleep, and has a far-seeing effect far superior to that of the western medicines; however, the medicine is three-part toxic compared with western medicines which injure the liver and the kidney, is only slightly less in burden on the liver and the kidney, belongs to a sedative medicine, does not remove insomnia roots, and still belongs to the category of headache doctors and foot doctors. The physical therapy is to improve insomnia by massage, foot bath, cupping, scraping therapy, acupuncture and moxibustion, hot compress, etc.; the medicine is not taken, the liver and the kidney are not damaged, the dependence is not caused, and the traditional Chinese medicine belongs to a natural therapy; however, the massage foot bath only has the adjusting function, and acupuncture, cupping and the like can be operated by professional personnel, so that the massage foot bath is inconvenient for family use, and has poor practicability for people without time. In addition, the traditional foot patch products can eliminate dampness and relieve foot fatigue; the traditional Chinese medicine mainly comprises bamboo vinegar, is alleged to improve insomnia, has no effect on basic failure, mostly adopts no antiallergic material, and can cause skin discomfort problems such as pimple and pruritus of people with sensitive skin.

At present, the medicines for treating insomnia comprise traditional Chinese medicines and western medicines, wherein the medicines which are commonly used and can quickly take effect are sleeping medicines in the western medicines. After long-term use of the hypnotic, not only can the dependence on the hypnotic be formed, but also various iatrogenic diseases such as damage to the liver and the kidney can be caused; impairment of the function of the digestive tract, etc., and side effects thereof are well known.

Disclosure of Invention

The invention aims to provide a cold compress gel for treating insomnia so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: a cold compress gel for treating insomnia comprises the following components: the traditional Chinese medicine composition comprises traditional Chinese medicine extract, melatonin, mirtazapine, poloxamer and water, wherein the traditional Chinese medicine extract is prepared by extracting the following raw materials: spina date seed, red date, plantain seed, Chinese angelica, ginseng, liquorice, platycodon grandiflorum, albizia flower, calamus and polygala tenuifolia.

Preferably, the weight parts of the components are as follows: 3-7 parts of traditional Chinese medicine extract, 2-4 parts of melatonin, 1-4 parts of mirtazapine, 7-13 parts of poloxamer and 106 parts of water.

Preferably, the weight parts of the components are as follows: 5 parts of traditional Chinese medicine extract, 3 parts of melatonin, 2.5 parts of mirtazapine, 10 parts of poloxamer and 103 parts of water.

Preferably, the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 9-13 parts of spina date seed, 6-8 parts of red date, 1-3 parts of semen plantaginis, 2-5 parts of angelica sinensis, 1-3 parts of ginseng, 1-3 parts of liquorice, 2-5 parts of platycodon grandiflorum, 2-5 parts of albizia flower, 1-3 parts of calamus and 1-3 parts of polygala tenuifolia.

Preferably, the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 11 parts of spina date seed, 7 parts of red date, 2 parts of semen plantaginis, 3.5 parts of angelica, 2 parts of ginseng, 2 parts of liquorice, 3.5 parts of platycodon grandiflorum, 3.5 parts of albizia flower, 2 parts of calamus and 2 parts of polygala tenuifolia.

The invention provides a preparation method of a cold compress gel for treating insomnia, which comprises the following steps:

1) weighing the components in parts by weight for later use;

(2) adding the Chinese medicinal extract into the weighed water, and stirring at high speed to completely dissolve the Chinese medicinal extract in the water;

(3) adding melatonin and mirtazapine, and stirring to mix well;

(4) adding poloxamer as a slow-release material, stirring uniformly, placing in a refrigerator at 3-7 deg.C, standing for 20-28 hr to make the gel fully swell and disperse uniformly until clear solution is obtained;

(5) packaging to obtain the cold compress gel.

Preferably, the preparation method of the traditional Chinese medicine extract comprises the following steps:

(1) weighing spina date seed, red date, plantain seed, angelica, ginseng, liquorice, platycodon grandiflorum, albizia flower, calamus and polygala tenuifolia according to the mass parts, and cleaning and removing impurities for later use;

(2) pulverizing and sieving the traditional Chinese medicine raw materials, and uniformly mixing for later use;

(3) adding 65-80% ethanol 7-15 times of the crude drug into the Chinese medicinal mixed powder, heating and reflux extracting for 1-3 hr, heating and reflux extracting for 2-3 times, filtering, mixing extractive solutions, and evaporating and concentrating ethanol at 30-45 deg.C under 0.2-0.3MPa to obtain extract with solid weight of 70-85%.

Pharmacological description:

melatonin: mainly can improve sleep (dosage is 0.1-0.3mg), shorten wake time before sleep and time to fall asleep, improve sleep quality, obviously reduce wake times in sleep, shorten light sleep stage, prolong deep sleep stage, and reduce wake threshold in the next morning. Has stronger function of adjusting time difference.

Mirtazapine: can be used for treating depression. Can be used for treating symptoms such as anhedonia, psychomotor depression, sleep disorder (early awakening), and weight loss. It can also be used for other symptoms such as loss of interest in things, suicidal ideation, and mood swings (good morning, bad evening).

Wild jujube seed: sweet and sour in flavor, neutral in nature, entering heart, liver and gallbladder meridians; has effects in nourishing heart, benefiting liver, tranquilizing mind, arresting sweating, treating insomnia, palpitation, spontaneous perspiration, and night sweat, tranquilizing mind, improving sleep, relieving convulsion, relieving pain, and cooling.

Red dates: sweet taste, warm nature, spleen and stomach meridians entered; has effects in invigorating middle warmer, invigorating qi, nourishing blood, tranquilizing mind, and relieving drug property.

Plantain seed: nature and taste: sweet and cold. Meridian tropism: enter liver, kidney, small intestine and lung meridians. The functions are as follows: induce diuresis and drain dampness, clear heat and improve eyesight, resolve phlegm and stop cough.

Chinese angelica: nature and taste: sweet, bitter, pungent and warm. Meridian tropism: enter heart, liver and spleen meridians. The functions are as follows: enriching blood, promoting blood circulation, regulating menstruation, moistening dryness, and smoothing intestine; tranquilizing and analgesic effects, and contains volatile oil as effective component.

Ginseng: sweet and slightly bitter in taste, warm and neutral in nature, and entering spleen, lung and heart meridians; invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, quenching thirst, tranquilizing mind, and improving intelligence; it can be used for treating fatigue, asthenia, anorexia, listlessness, regurgitation, diarrhea, cough, dyspnea, spontaneous perspiration, palpitation, amnesia, vertigo, headache, sexual impotence, frequent micturition, diabetes, metrorrhagia, infantile pavor, and deficiency of qi, blood, and body fluid.

Licorice root: sweet in taste, neutral in nature, and entering heart, lung, spleen and stomach meridians; invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs.

Balloon flower: mild in nature, bitter and pungent in flavor. It enters lung meridian. The efficacy is as follows: dispersing lung qi, eliminating phlegm, relieving sore throat, and expelling pus. Belongs to heat-phlegm-clearing herbs classified under phlegm-resolving, cough-relieving and asthma-relieving herbs.

Albizzia flower: sweet in nature and taste, mild, soothing depression, regulating qi, tranquilizing, activating collaterals, nourishing blood, nourishing yin and kidney, clearing heart fire and improving eyesight.

Calamus: nature and taste: pungent, bitter and warm. Meridian tropism: enter heart and stomach meridians. The functions are as follows: inducing resuscitation, eliminating phlegm, refreshing mind, strengthening brain, eliminating dampness, and stimulating appetite.

Polygala root: warm in nature, bitter and pungent in flavor. They enter heart, kidney and lung meridians. Tranquilization and intelligence development, phlegm elimination and detumescence belong to the category of tranquilizers.

Has the advantages that: the invention has the beneficial effects that: the cold compress gel for treating insomnia provided by the invention realizes perfect combination of traditional Chinese medicines and western medicines, overcomes the defects of large side effect and dependency generation of the western medicines, solves the problem of slow effect of the traditional Chinese medicines, relieves the side effect, reduces the drug dependency and relieves the burden of liver and kidney while quickly relieving the insomnia symptom, and meets the requirements of modern people on the insomnia medicines in the aspects of curative effect, side effect, health and the like.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Example 1

The cold compress gel for treating insomnia comprises the following components in parts by weight: 3 parts of a traditional Chinese medicine extract, 2 parts of melatonin, 1 part of mirtazapine, 7 parts of poloxamer and 100 parts of water, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 9 parts of spina date seed, 6 parts of red date, 1 part of semen plantaginis, 2 parts of angelica sinensis, 1 part of ginseng, 1 part of liquorice, 2 parts of platycodon grandiflorum, 2 parts of albizia flower, 1 part of calamus and 1 part of polygala tenuifolia.

Example 2

The cold compress gel for treating insomnia comprises the following components in parts by weight: 3-7 parts of a traditional Chinese medicine extract, 3 parts of melatonin, 2.5 parts of mirtazapine, 10 parts of poloxamer and 103 parts of water, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 11 parts of spina date seed, 7 parts of red date, 2 parts of semen plantaginis, 3.5 parts of angelica, 2 parts of ginseng, 2 parts of liquorice, 3.5 parts of platycodon grandiflorum, 3.5 parts of albizia flower, 2 parts of calamus and 2 parts of polygala tenuifolia.

Example 3

The cold compress gel for treating insomnia comprises the following components in parts by weight: 3-7 parts of a traditional Chinese medicine extract, 4 parts of melatonin, 4 parts of mirtazapine, 13 parts of poloxamer and 106 parts of water, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 13 parts of spina date seed, 8 parts of red date, 3 parts of semen plantaginis, 5 parts of angelica sinensis, 3 parts of ginseng, 3 parts of liquorice, 5 parts of platycodon grandiflorum, 5 parts of albizia flower, 3 parts of calamus and 3 parts of polygala tenuifolia.

The cold compress gel for treating insomnia in the above examples 1 to 3 was prepared by the following steps:

(1) weighing the components in parts by weight for later use;

(2) adding the Chinese medicinal extract into the weighed water, and stirring at high speed to completely dissolve the Chinese medicinal extract in the water;

(3) adding melatonin and mirtazapine, and stirring to mix well;

(4) adding poloxamer as a slow-release material, stirring uniformly, placing in a refrigerator at 3-7 deg.C, standing for 20-28 hr to make the gel fully swell and disperse uniformly until clear solution is obtained;

(5) packaging to obtain the cold compress gel.

The preparation method of the traditional Chinese medicine extract comprises the following steps:

(1) weighing spina date seed, red date, plantain seed, angelica, ginseng, liquorice, platycodon grandiflorum, albizia flower, calamus and polygala tenuifolia according to the mass parts, and cleaning and removing impurities for later use;

(2) pulverizing and sieving the traditional Chinese medicine raw materials, and uniformly mixing for later use;

(3) adding 65-80% ethanol 7-15 times of the crude drug into the Chinese medicinal mixed powder, heating and reflux extracting for 1-3 hr, heating and reflux extracting for 2-3 times, filtering, mixing extractive solutions, and evaporating and concentrating ethanol at 30-45 deg.C under 0.2-0.3MPa to obtain extract with solid weight of 70-85%.

The cold compress gel for treating insomnia provided by the invention realizes perfect combination of traditional Chinese medicines and western medicines, overcomes the defects of great side effect and dependency generation of the western medicines, solves the problem of slow response of the traditional Chinese medicines, relieves the side effect, reduces the drug dependency and the burden of liver and kidney while quickly relieving the insomnia symptom, and meets the requirements of modern people on the insomnia medicines in the aspects of curative effect, side effect, health and the like

The embodiments described above are preferred embodiments of the present invention, and not all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (7)

1. A cold compress gel for treating insomnia is characterized by comprising the following components: the traditional Chinese medicine composition comprises traditional Chinese medicine extract, melatonin, mirtazapine, poloxamer and water, wherein the traditional Chinese medicine extract is prepared by extracting the following raw materials: spina date seed, red date, plantain seed, Chinese angelica, ginseng, liquorice, platycodon grandiflorum, albizia flower, calamus and polygala tenuifolia.

2. The cold compress gel for treating insomnia according to claim 1, wherein the weight parts of each component are as follows: 3-7 parts of traditional Chinese medicine extract, 2-4 parts of melatonin, 1-4 parts of mirtazapine, 7-13 parts of poloxamer and 106 parts of water.

3. The cold compress gel for treating insomnia according to claim 1, wherein the weight parts of each component are as follows: 5 parts of traditional Chinese medicine extract, 3 parts of melatonin, 2.5 parts of mirtazapine, 10 parts of poloxamer and 103 parts of water.

4. The cold compress gel for treating insomnia according to any one of claims 1 to 3, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 9-13 parts of spina date seed, 6-8 parts of red date, 1-3 parts of semen plantaginis, 2-5 parts of angelica sinensis, 1-3 parts of ginseng, 1-3 parts of liquorice, 2-5 parts of platycodon grandiflorum, 2-5 parts of albizia flower, 1-3 parts of calamus and 1-3 parts of polygala tenuifolia.

5. The cold compress gel for treating insomnia according to claim 4, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 11 parts of spina date seed, 7 parts of red date, 2 parts of semen plantaginis, 3.5 parts of angelica, 2 parts of ginseng, 2 parts of liquorice, 3.5 parts of platycodon grandiflorum, 3.5 parts of albizia flower, 2 parts of calamus and 2 parts of polygala tenuifolia.

6. A preparation method of cold compress gel for treating insomnia is characterized by comprising the following steps:

(1) weighing the components in parts by weight for later use;

(2) adding the Chinese medicinal extract into the weighed water, and stirring at high speed to completely dissolve the Chinese medicinal extract in the water;

(3) adding melatonin and mirtazapine, and stirring to mix well;

(4) adding poloxamer as a slow-release material, stirring uniformly, placing in a refrigerator at 3-7 deg.C, standing for 20-28 hr to make the gel fully swell and disperse uniformly until clear solution is obtained;

(5) packaging to obtain the cold compress gel.

7. The preparation method of the cold compress gel for treating insomnia according to claim 6, wherein the preparation method of the traditional Chinese medicine extract comprises the following steps:

(1) weighing spina date seed, red date, plantain seed, angelica, ginseng, liquorice, platycodon grandiflorum, albizia flower, calamus and polygala tenuifolia according to the mass parts, and cleaning and removing impurities for later use;

(2) pulverizing and sieving the traditional Chinese medicine raw materials, and uniformly mixing for later use;

(3) adding 65-80% ethanol 7-15 times of the crude drug into the Chinese medicinal mixed powder, heating and reflux extracting for 1-3 hr, heating and reflux extracting for 2-3 times, filtering, mixing extractive solutions, and evaporating and concentrating ethanol at 30-45 deg.C under 0.2-0.3MPa to obtain extract with solid weight of 70-85%.