CN116134141A - 包含小型化胞苷脱氨酶的双链dna修饰用复合体 - Google Patents

包含小型化胞苷脱氨酶的双链dna修饰用复合体 Download PDF

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CN116134141A
CN116134141A CN202180054915.9A CN202180054915A CN116134141A CN 116134141 A CN116134141 A CN 116134141A CN 202180054915 A CN202180054915 A CN 202180054915A CN 116134141 A CN116134141 A CN 116134141A
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amino acid
deaminase
acid sequence
complex
lys
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西田敬二
李昂
光延仁志
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Kobe University NUC
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Kobe University NUC
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    • C12N9/14Hydrolases (3)
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/14Hydrolases (3)
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    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005Cytidine deaminase (3.5.4.5)
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Enzymes And Modification Thereof (AREA)
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CN202180054915.9A 2020-09-04 2021-09-06 包含小型化胞苷脱氨酶的双链dna修饰用复合体 Pending CN116134141A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020149419 2020-09-04
JP2020-149419 2020-09-04
PCT/JP2021/032689 WO2022050413A1 (ja) 2020-09-04 2021-09-06 小型化シチジンデアミナーゼを含む二本鎖dnaの改変用複合体

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CN116134141A true CN116134141A (zh) 2023-05-16

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CN202180054915.9A Pending CN116134141A (zh) 2020-09-04 2021-09-06 包含小型化胞苷脱氨酶的双链dna修饰用复合体

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US (1) US20230323335A1 (https=)
EP (1) EP4209589A4 (https=)
JP (1) JPWO2022050413A1 (https=)
KR (1) KR20230061474A (https=)
CN (1) CN116134141A (https=)
AU (1) AU2021336262A1 (https=)
BR (1) BR112023003972A2 (https=)
CA (1) CA3194019A1 (https=)
WO (1) WO2022050413A1 (https=)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1476547B1 (en) 2002-01-23 2006-12-06 The University of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
CN1856576B (zh) 2003-09-30 2011-05-04 宾夕法尼亚州立大学托管会 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
WO2010012077A1 (en) 2008-07-28 2010-02-04 Mount Sinai Hospital Compositions, methods and kits for reprogramming somatic cells
HUE041436T2 (hu) 2009-12-10 2019-05-28 Univ Minnesota Tal-effektor-közvetített DNS-módosítás
JP2013128413A (ja) 2010-03-11 2013-07-04 Kyushu Univ Pprモチーフを利用したrna結合性蛋白質の改変方法
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
US11685935B2 (en) * 2013-05-29 2023-06-27 Cellectis Compact scaffold of Cas9 in the type II CRISPR system
SG11201609211VA (en) 2014-03-05 2016-12-29 Nat Univ Corp Univ Kobe Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
JP2020510439A (ja) * 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
CA3057192A1 (en) * 2017-03-23 2018-09-27 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable dna binding proteins
US20200172895A1 (en) * 2017-05-25 2020-06-04 The General Hospital Corporation Using split deaminases to limit unwanted off-target base editor deamination
JP6727680B2 (ja) 2018-03-26 2020-07-22 国立大学法人神戸大学 細胞の有する二本鎖dnaの標的部位を改変する方法
JP7487939B2 (ja) * 2018-11-01 2024-05-21 国立大学法人 東京大学 2分割されたCpf1タンパク質
KR20210121113A (ko) * 2019-01-31 2021-10-07 빔 테라퓨틱스, 인크. 비-표적 탈아미노화가 감소된 핵염기 편집기 및 핵염기 편집기를 특성규명하기 위한 분석
KR20210139265A (ko) * 2019-02-13 2021-11-22 빔 테라퓨틱스, 인크. 표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법
JP7234711B2 (ja) 2019-03-14 2023-03-08 富士フイルムビジネスイノベーション株式会社 メッセージ通知装置、コンテンツ管理システム及びプログラム

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Publication number Publication date
KR20230061474A (ko) 2023-05-08
AU2021336262A1 (en) 2023-05-18
EP4209589A4 (en) 2024-09-25
AU2021336262A9 (en) 2024-09-05
WO2022050413A1 (ja) 2022-03-10
US20230323335A1 (en) 2023-10-12
BR112023003972A2 (pt) 2023-04-18
CA3194019A1 (en) 2022-03-10
EP4209589A1 (en) 2023-07-12
JPWO2022050413A1 (https=) 2022-03-10

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