JPWO2022050413A1 - - Google Patents
Info
- Publication number
- JPWO2022050413A1 JPWO2022050413A1 JP2022546998A JP2022546998A JPWO2022050413A1 JP WO2022050413 A1 JPWO2022050413 A1 JP WO2022050413A1 JP 2022546998 A JP2022546998 A JP 2022546998A JP 2022546998 A JP2022546998 A JP 2022546998A JP WO2022050413 A1 JPWO2022050413 A1 JP WO2022050413A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04005—Cytidine deaminase (3.5.4.5)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020149419 | 2020-09-04 | ||
| PCT/JP2021/032689 WO2022050413A1 (ja) | 2020-09-04 | 2021-09-06 | 小型化シチジンデアミナーゼを含む二本鎖ｄｎａの改変用複合体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2022050413A1 true JPWO2022050413A1 (https=) | 2022-03-10 |
Family
ID=80492029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022546998A Pending JPWO2022050413A1 (https=) | 2020-09-04 | 2021-09-06 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230323335A1 (https=) |
| EP (1) | EP4209589A4 (https=) |
| JP (1) | JPWO2022050413A1 (https=) |
| KR (1) | KR20230061474A (https=) |
| CN (1) | CN116134141A (https=) |
| AU (1) | AU2021336262A1 (https=) |
| BR (1) | BR112023003972A2 (https=) |
| CA (1) | CA3194019A1 (https=) |
| WO (1) | WO2022050413A1 (https=) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020160514A1 (en) * | 2019-01-31 | 2020-08-06 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1476547B1 (en) | 2002-01-23 | 2006-12-06 | The University of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| CN1856576B (zh) | 2003-09-30 | 2011-05-04 | 宾夕法尼亚州立大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| WO2010012077A1 (en) | 2008-07-28 | 2010-02-04 | Mount Sinai Hospital | Compositions, methods and kits for reprogramming somatic cells |
| HUE041436T2 (hu) | 2009-12-10 | 2019-05-28 | Univ Minnesota | Tal-effektor-közvetített DNS-módosítás |
| JP2013128413A (ja) | 2010-03-11 | 2013-07-04 | Kyushu Univ | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の改変方法 |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| US11685935B2 (en) * | 2013-05-29 | 2023-06-27 | Cellectis | Compact scaffold of Cas9 in the type II CRISPR system |
| SG11201609211VA (en) | 2014-03-05 | 2016-12-29 | Nat Univ Corp Univ Kobe | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| JP2020510439A (ja) * | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) * | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US20200172895A1 (en) * | 2017-05-25 | 2020-06-04 | The General Hospital Corporation | Using split deaminases to limit unwanted off-target base editor deamination |
| JP6727680B2 (ja) | 2018-03-26 | 2020-07-22 | 国立大学法人神戸大学 | 細胞の有する二本鎖ｄｎａの標的部位を改変する方法 |
| JP7487939B2 (ja) * | 2018-11-01 | 2024-05-21 | 国立大学法人 東京大学 | ２分割されたＣｐｆ１タンパク質 |
| KR20210139265A (ko) * | 2019-02-13 | 2021-11-22 | 빔 테라퓨틱스, 인크. | 표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법 |
| JP7234711B2 (ja) | 2019-03-14 | 2023-03-08 | 富士フイルムビジネスイノベーション株式会社 | メッセージ通知装置、コンテンツ管理システム及びプログラム |
-
2021
- 2021-09-06 CA CA3194019A patent/CA3194019A1/en active Pending
- 2021-09-06 EP EP21864464.9A patent/EP4209589A4/en active Pending
- 2021-09-06 AU AU2021336262A patent/AU2021336262A1/en active Pending
- 2021-09-06 CN CN202180054915.9A patent/CN116134141A/zh active Pending
- 2021-09-06 WO PCT/JP2021/032689 patent/WO2022050413A1/ja not_active Ceased
- 2021-09-06 KR KR1020237011179A patent/KR20230061474A/ko active Pending
- 2021-09-06 US US18/044,047 patent/US20230323335A1/en active Pending
- 2021-09-06 BR BR112023003972A patent/BR112023003972A2/pt unknown
- 2021-09-06 JP JP2022546998A patent/JPWO2022050413A1/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020160514A1 (en) * | 2019-01-31 | 2020-08-06 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
Non-Patent Citations (3)
| Title |
|---|
| ARUNKUMAR KRISHNAN ET AL.: ""Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread ro", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 115, JPN6025033156, 2018, ISSN: 0005781144 * |
| JUNJIE TAN ET AL.: ""Engineering of high-precision base editors for site-specific single nucleotide replacement"", NATURE COMMUNICATIONS, vol. 10, JPN6021046286, 2019, ISSN: 0005781142 * |
| JUNJIE TAN ET AL.: ""Expanding the genome-targeting scope and the site selectivity of high-precision base editors"", NATURE COMMUNICATIONS, vol. 11, JPN6021046288, 31 January 2020 (2020-01-31), ISSN: 0005781143 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230061474A (ko) | 2023-05-08 |
| AU2021336262A1 (en) | 2023-05-18 |
| EP4209589A4 (en) | 2024-09-25 |
| AU2021336262A9 (en) | 2024-09-05 |
| WO2022050413A1 (ja) | 2022-03-10 |
| US20230323335A1 (en) | 2023-10-12 |
| BR112023003972A2 (pt) | 2023-04-18 |
| CA3194019A1 (en) | 2022-03-10 |
| EP4209589A1 (en) | 2023-07-12 |
| CN116134141A (zh) | 2023-05-16 |
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