CN116134044B - 化合物及使用了该化合物的标记生物物质 - Google Patents

化合物及使用了该化合物的标记生物物质

Info

Publication number
CN116134044B
CN116134044B CN202180060816.1A CN202180060816A CN116134044B CN 116134044 B CN116134044 B CN 116134044B CN 202180060816 A CN202180060816 A CN 202180060816A CN 116134044 B CN116134044 B CN 116134044B
Authority
CN
China
Prior art keywords
group
compound
substituent
carbon atoms
biological substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180060816.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN116134044A (zh
Inventor
金泽吉宪
藤原良
込山和兴
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of CN116134044A publication Critical patent/CN116134044A/zh
Application granted granted Critical
Publication of CN116134044B publication Critical patent/CN116134044B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Steroid Compounds (AREA)
CN202180060816.1A 2020-07-30 2021-07-29 化合物及使用了该化合物的标记生物物质 Active CN116134044B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-129754 2020-07-30
JP2020129754 2020-07-30
PCT/JP2021/028180 WO2022025210A1 (ja) 2020-07-30 2021-07-29 化合物及びこれを用いた標識生体物質

Publications (2)

Publication Number Publication Date
CN116134044A CN116134044A (zh) 2023-05-16
CN116134044B true CN116134044B (zh) 2026-03-17

Family

ID=80036338

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180060816.1A Active CN116134044B (zh) 2020-07-30 2021-07-29 化合物及使用了该化合物的标记生物物质

Country Status (5)

Country Link
US (1) US12522609B2 (https=)
EP (1) EP4190795A4 (https=)
JP (1) JP7423789B2 (https=)
CN (1) CN116134044B (https=)
WO (1) WO2022025210A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7787670B2 (ja) * 2021-08-31 2025-12-17 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
JPWO2024143263A1 (https=) 2022-12-26 2024-07-04
CN120752249A (zh) 2023-02-27 2025-10-03 富士胶片株式会社 化合物及使用了该化合物的标记生物物质

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0670374A1 (en) * 1994-03-01 1995-09-06 Li-Cor, Inc. A method of identifying strands of DNA using infrared fluorescent labels
US6403807B1 (en) * 1999-07-06 2002-06-11 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2423806C (en) 2000-09-29 2009-12-22 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
WO2005000218A2 (en) 2003-05-31 2005-01-06 Washington University Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications
US7465810B2 (en) 2004-10-25 2008-12-16 Anaspec, Inc. Reactive 1,3′-crosslinked carbocyanine
WO2009078970A1 (en) 2007-12-14 2009-06-25 Biotium, Inc. Fluorescent compounds
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
WO2013130761A1 (en) * 2012-03-02 2013-09-06 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
US20150073154A1 (en) * 2013-09-11 2015-03-12 Equip, Llc Discrete PEG Based Dyes
JP7279387B2 (ja) 2019-02-08 2023-05-23 株式会社Ｊｖｃケンウッド 中継局、中継装置、および中継方法
JP7441306B2 (ja) 2020-04-24 2024-02-29 富士フイルム株式会社 化合物及びこれを用いた標識生体物質

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0670374A1 (en) * 1994-03-01 1995-09-06 Li-Cor, Inc. A method of identifying strands of DNA using infrared fluorescent labels
US6403807B1 (en) * 1999-07-06 2002-06-11 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays

Also Published As

Publication number Publication date
EP4190795A4 (en) 2024-08-28
US20230159547A1 (en) 2023-05-25
EP4190795A1 (en) 2023-06-07
CN116134044A (zh) 2023-05-16
JP7423789B2 (ja) 2024-01-29
JPWO2022025210A1 (https=) 2022-02-03
WO2022025210A1 (ja) 2022-02-03
US12522609B2 (en) 2026-01-13

Similar Documents

Publication Publication Date Title
CN116134044B (zh) 化合物及使用了该化合物的标记生物物质
JP7550076B2 (ja) 蛍光色素及びこれを用いた標識生体物質
JP7359869B2 (ja) 化合物及びこれを用いた蛍光標識生体物質
US12559476B2 (en) Compound and labeled biological substance using the same
US20240173437A1 (en) Compound and labeled biological substance using the same
US20250314658A1 (en) Fluorescence intensity enhancer, fluorescence intensity enhancing method of fluorescently labeled target biological substance, and kit for fluorescence detection
WO2022191123A1 (ja) 蛍光性化合物及びこれを用いた蛍光標識生体物質
US20240182383A1 (en) Compound and labeled biological substance using the same
JP7787670B2 (ja) 化合物及びこれを用いた標識生体物質
US20240165240A1 (en) Compound and labeled biological substance using the same
CN117460789B (zh) 化合物及使用了该化合物的标记生物物质
CN117460790B (zh) 荧光性化合物及使用了该荧光性化合物的荧光标记生物物质
CN117642412A (zh) 化合物及使用了该化合物的标记生物物质
US20250389724A1 (en) Compound and labeled biological substance using the same
WO2025197851A1 (ja) 蛍光性化合物
JP2023059377A (ja) 蛍光性化合物及びこれを用いた蛍光標識生体物質
CN117642414A (zh) 化合物及使用了该化合物的标记生物物质

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant