CN1161133C - Liposoluble Chinese medicine rectal suppository for treating acute and chronic prostatitis - Google Patents

Abstract

The present invention relates to a liposoluble Chinese medicine suppository through rectal administration for treating prostatitis, which is prepared from Chinese medicine raw materials and used for treating infections caused by complicated pathogenic microorganisms (bacteria, viruses, mildew, trichomonad, mycoplasma, chlamydia, colibacillus and bacterium aerogenes, such as Gram-positive coccus, golden staphylococcus, etc.) and chronic aseptic prostatitis. Danshen root, red peony root, dandelion, tokyo violet herb, dragon blood, yellow-corktree bark, frankincense, myrrh, musk and borneol mutton fat are used as raw materials, the raw materials are processed by Chinese medicines and extracted into liquid extract dry powder, and then the Chinese medicine suppository of liposoluble matrixes is prepared. The liposoluble Chinese medicine suppository has the functions of blood activation, stasis dissipation, heat elimination, diuresis promotion, dephlogistication, pain alleviation, stranguria treatment and urination promotion, and has favorable curative effect on various types of acute and chronic prostatitis; the liposoluble Chinese medicine suppository belongs to the new medicinal species of medicinal suppositories through anorectum administration in China, which aim at treating prostatitis.

Description

A kind of fat-soluble Chinese medicine suppository of rectal for the treatment of acute and chronic prostatitis

The present invention be a kind of at disease pathogen microorganism (antibacterial, virus, mycete, infusorian, mycoplasma, chlamydia, escherichia coli, aerobacteria such as Gram-positive coccus-gold-coloured staphylococci etc.) infect the acute and chronic prostatitis disease cause and nonspecific prostatitis and invent rectal Chinese medicine preparation-fat-soluble suppository, belong to drug world.

Acute and chronic prostatitis is meant the infectious urethritis owing to the property contact, prostatitis is the male genital commonly encountered diseases of adult, pilosity is born in 20 years old-40 years old person between twenty and fifty, the modal symptom of this disease is followed successively by: urethra drips white, soreness of the waist and knees, dribble of urine, lower abdominal distention pain, cloudy urine, dizzy dizziness, insomnia and dreamful sleep, waist sacrum distending pain, testis and spermatic cord distending pain, urethra causalgia, sexual impotence, premature ejaculation etc.

Current prostatitis sickness rate than higher (in the male person between twenty and fifty of 20-45, prostatitic sickness rate reaches more than the 25-45%, also reach more than 25% because of suffering from acute and chronic prostatitis prescription on individual diagnosis person in the Urologic Surgery Clinic at home, wherein 35 years old-40 years old sickness rate can be up to 40%.), infective pathogen microorganism complexity (antibacterial, virus, mycete, infusorian, mycoplasma, chlamydia, escherichia coli, aerobacteria such as Gram-positive coccus-box color staphylococcus etc.), general water solublity antibacterials are because prostate position is darker, the circulation of body of gland inner blood is not smooth, the body of gland outer wrapping three layers of adipose membrane, even reason such as prostate aseptic inflammation is difficult to penetrate prostate and to prostatitis elimination effect targetedly, faint for the prostatitis effect, the tradition oral drugs are through stomach, intestinal, liver, gallbladder, absorptions such as kidney consume and the consumption of blood circulation road is difficult in the enough blood drug level of prostatic cohesion, current other numerous treatment ways that in clinical, developed, as: physical therapy (hot water hip-bath, ultrasound wave, shortwave or ultrashort wave, microwave, acipoint magnetotheraphy, laser, mechanical shock), massage of prostate, two capsule four cavities conduit pipe administrations, direct injection (per rectum or perineum), the medicine unidirectional current imports, but above various way, want petty damage testicular spermatogenic, wanting petty only is auxiliary treatment means, even certain methods complicated operation, and it is dangerous in addition, problems such as cross infection, the suppository of other rectals, unguentum exists dosage form unreasonable, compatibility is science not, the disadvantage that curative effect is relatively poor.

Ancient Times in China medical science is with acute and chronic prostatitis ownership " stranguria " category.China's tradition traditional Chinese medical science early has penetrating argumentation for prostatitis.The time advance the turbid person of Weihe: ＂ as Xu of the Qing Dynasty, white sticking as smart shape flows out from stem, and is not puckery bitterly, and accounting for down clothing has the mark person is also.＂ adds: the smart turbid person of ＂, the stem fire that seemingly lancinates burns, and the key of drowning, the disease being located in the liver spleen: turbidly go out orifice for discharging seminal fluid, the disease being located in the heart kidney.＂ clinical findings, primary disease major lesions position are at kidney, and be also relevant with bladder, heart spleen, liver etc., and ＂ orifice for discharging seminal fluid ＂ should be the histoorgan that seminal fluid is formed in secretions such as prostate, seminal vesicle, cowper gland.The primary disease cause of disease is intricate, and in a word adopting is that to lose essence stasis turbid, damp invasion of lower energizer.Smart closing admittedly.Main diseases is because of being to bear smart ＂ and ＂ to infect ＂.The former is many by the mutually fiery movability of person between twenty and fifty, and it is unsuccessful that institute is willing to, essence stays in, and the stasis of blood is in smart chamber: or seminal emission, masturbation, cause in terror, bear essence not penetrate, lose smart multiple abscess, satisfy and become essence turbid.The latter is how plain empty by the spleen lung, the priming damp-heat in lower-JIAO; Or redundant prepuce, sexual intercourse is unclean, and damp and hot heresy is invaded on the key by urine, scurries in smart turbid and mixes mutually, smartly forms primary disease from it.The food rich and fatty diet is had a liking in excessive drinking smoking, also can make to give birth in damp and hot, makes a bet smart chamber and causes primary disease.Generally, acute and chronic prostatitis is main cause with damp-heat syndrome, blood stasis disease, middle deficient syndrome, kidney deficiency on endogenous cause of ill and carries out disease type classification.

Doctor Wang Guangyu is just according to the summary of experience of practising medicine from generation to generation, use for reference of the argumentation of China's tradition traditional Chinese medical science to this disease, the scientific knowledge of comprehensive Chinese and western medical science, pharmacology, the pharmacology of Chinese medical formulae, succeed in developing the outstanding prescription-prostatitis urinary system suppository of per anum rectally treatment acute and chronic prostatitis disease through exploring for many years, obtain treatment effective percentage 98%, the better therapeutic effect of cure rate 60%.

We start with from the research of the Chinese medicine of motherland's traditional medicine at the selected topic for this reason, with the symptom of " stranguria " category contrast acute and chronic inflammation of Chinese medicine and pharmacy, attached inspection means with the modern times, compatibility meticulously.Explore dissolving absorption efficiency height after a treating both the principal and secondary aspects of a disease, convenient drug administration, the per anum administration at acute and chronic prostatitis treatment, be penetrated into prostate interior tissue body of gland interior lumen and treat short treating period, curative effect is rapid, cure rate is high, relapse rate is low, be suitable for the new drug that the crowd is wide, have no side effect.

Therefore, the object of the invention provides a kind of anum administration suppository Chinese medicine for the treatment of acute and chronic prostatitis,

Inventor Wang Guang space is on the basis of secret prescription handed down in the family from generation to generation treatment " stranguria ", not only consider to invade the mark reality that damp and hot heresy is accumulate long-pending bladder outward, more consider the deficiency in origin of deficiency of the kidney, adopt the method for strengthening vital QI to eliminate pathogenic factors, make to set upright and do not love heresy, not eliminating evil just the wound, the science of carrying out compatibility is through the cooperation that clinical summary widely and definite efficacy analysis and doctor trained in Western medicine are checked means, repeated screening, the chemical examination authentication, development cost invention medicine.

The basic composition of medicine of the present invention is to be effective ingredient (calculating according to weight) with following pharmaceutical composition:

2 parts of Adeps caprae seu ovis 15-20 of Radix Salviae Miltiorrhizae 10-30 part Radix Paeoniae Rubra 10-16 part Herba Taraxaci 10-16 part Herba Violae 10-16 part Sanguis Draxonis 2-4.6 part Cortex Phellodendri 10-16 part Olibanum Myrrha 1 part of Borneolum Syntheticum of each 2-4.6 part Moschus part

Aforementioned pharmaceutical compositions of the present invention according to the Chinese medicine suppository preparation process, can be prepared from.

The preparation method of anum administration suppository medicine of the present invention is: the fluid extract dry powder of getting said medicine (except that Adeps caprae seu ovis) is added in (Adeps caprae seu ovis) in the dissolved matrix, stirs, and impouring scribbles in the bolt mould of lubricant, and cooling is taken out.

The effect of invention medicine, characteristics, superiority:

Medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, anti-inflammatory analgetic, diuresis promoting, this medical suppository invention treatment acute and chronic prostatitis curative effect height, and instant effect, non-evident effect, effective percentage are up to 98%, and cure rate reaches 60%.Its curative effect is apparently higher than antibiotic therapy.Especially the mixed infection patient who delays for those obstinates, the state of an illness, and antibiotics drug resistance patient, nonspecific prostatitis patient through after the treatment of 2-3 the course of treatment, also all obtain to cure.Clinical drug safety, it is extensive to be suitable for the crowd, is subjected to the extensive patients favorable comment deeply.

Embodiment:

Zhengzhou City's wide space andropathy infertility institute used in recent years by the prostatitis urinary system bolt anum administration of Wang Guangyu chief's invention and treated this acute and chronic prostatitis, had obtained comparatively encouraging result.Now be reported as follows:

(1), physical data

This is organized 246 examples and is the outpatient, and wherein the age is in 6 examples below 20 years old, 21-40 year 167 examples, 41-60 year 65 examples, 8 examples more than 61 years old.Age reckling 17 years old, soprano 69 years old.Unmarried 51 examples, married 195 examples, course of disease 1-6 month 43 examples, 7-18 month 166 examples, 18 months-36 months 37 examples.

(2), diagnosis basis

1, clinical manifestation: paruria, the urine meaning reaches urethra not to the utmost scratchy, burning sensation; Urethral orifice has mucus, haircuts, and perhaps the defecation end is seen has milky secretions to discharge; There is pain in various degree at perineum, anus position and the sense of weigh down expanding, and often draw and testis, lower abdomen, lumbosacral region distending pain discomfort; General Symptoms has the neurasthenia, or premature ejaculation, seminal emission, sexual impotence, painful ejaculation, sexual function and reproductive function obstacle such as sterile.

2, anus touch: prostatauxe is touched a tender spot, the quality hardening, smooth surface, and intermediate sulcus shoals or disappears.

3, examination of prostatic fluid: lecithin reduces, leukocyte greater than 10 or pus cell "+" above/every high power field.

4, bacteriology checking: have 98 examples to carry out antibacterial culturing, counting and drug sensitive experiment according to the Meares method.Pathogenic bacterium 57 examples of growing are arranged.Asepsis growth 41 examples.Fructus Vins coccus 14 examples in the bacterium case history are arranged, staphylococcus aureus 5 examples, streptococcus faecalis 2 examples, tetracoccus 2 examples, escherichia coli 3 examples, paracolon 1 example, gonococcus 3 examples, chlamydia trachomatis 16 examples, Ureaplasma urealyticum 14 examples, mycoplasma hominis 2 examples, mycete 1 example.

(3), Therapeutic Method

The prostatitis urinary system bolt anum administration that 246 examples all use us to develop, every day sooner or later each once, each 1-2 grain (2 of inflammation severe patients), 20 days is a course of treatment.

1, clinical symptoms contrast before and after the treatment

Symptom contrast before and after table 1 treatment

The number effective percentage is alleviated in clinical symptoms treatment precedent number treatment back

Urine retention, urethral irritation have scorching hot prodding and itching feeling 195 192 98.46%

Urethral orifice has viscose silk or drips white phenomenon 84 81 96.43%

Perineum, podex have distending pain, bearing down 139 99 71.22%

Testis is taken out pain and waist and sacrum pain 56 50 89.29%

Few abdominal part, groin distending pain uncomfortable 122 78 63.93%

Ejaculation back stomachache 31 26 83.87%

Functional sexual impotence 138 127 92.03%

Premature ejaculation, seminal emission 208 168 80.77%

Hematuria, hemospermia 32 66.67%

Feel depressed, have no end of misgivings 93 36 38.71%

2, efficacy determination

Recovery from illness: clinical symptom disappearance, anus are examined the body of gland enlargement and are disappeared, no tenderness, and it is normal that Rolandic fissure recovers; The gland fluid inspection, under every high power field, the leukocyte number is lower than below 10; It is normal that lecithin recovers.

Produce effects: clinical symptoms disappear substantially or obviously alleviate, gland liquid is conventional near normal, prostate does not have obvious tenderness.

Take a turn for the better: subjective symptoms disappears or significantly alleviates, and anus is examined the body of gland enlargement and disappeared substantially, no tenderness; The more preceding obvious minimizing of gland fluid inspection leukocyte number, lecithin increases or is normal substantially.

Invalid: symptom does not have obvious improvement more than the course of treatment in 2 of medications, and anus is examined and the prostatic fluid no change

(4), therapeutic outcome (seeing Table two)

Table two: curative effect statistics

Case load is cured (%) produce effects (%) improvement (%) invalid (%) total effective rate

246 148(60％) 55(22.4％) 37(15.6％) 6(2％) 98％

(5) cognition and analysis:

Strengthen scientific research, make great efforts to explore safe, efficient, the new channel that side effect is little, with strong points, simple to operate, relatively cheap of a treatment nonspecific prostatitis and specific prostatitis, prostatodynia, make numerous prostatosis patients remove slight illness early, the life of getting well is the developing significant medical difficult problem of current Chinese medicine and task.

Prostatosis is the common disease of male, can bring out sexual dysfunction, infertility etc.Dissect from prostate, the prostate surface is surrounded by the tough and tensile fibrous layer of one deck, and rectum front wall is pressed close in the back.According to general conventional route administration, medicine is difficult to directly to enter body of gland inside and works, so therapeutic effect is undesirable, causes the delay refractory more.Adopting Chinese medicine suppository anus local application, directly arrive prostate by rectum, is a kind of simple and easy to do and eutherapeutic method to the treatment prostatosis, and cureless prostatosis is had instant effect, evident in efficacy, the difficult unique effects that recurs.

And the treatment acute and chronic prostatitis must be at the prostatic anatomical features of scientific analysis, the organ-tissue architectural characteristic, prostate itself absorbs, drain, body of gland inner loop feature, on the physiological function basis, the utilization modern pharmacology, the advanced knowledge of materia medica class, with motherland's tradition Chinese medicine pharmacology of Chinese medical formulae serves as basic, at in the prostate treatment because traditional administration and general suppository, the shortcoming of unguentum and the up-to-date suitable prescription that designs, doctor Wang Guangyu is composing prescription preparation under this thought guidance just, the prostatitis urinary system bolt fatsolvent of invention herbal classic rectal has been obtained the good clinical therapeutic effect.

The complicated refractory of prostatosis is not only its cause of disease complexity, but also relevant with following factor:

1, anatomical factors:

A, prostate position exist deeply, its juice excretes after need entering urethra through ducts of prostate gland again, and prostate central area secretions is discharged easily, and the ducts of prostate gland of perimeter region and urethra are rectangular or diagonal enters urethra, secretions is difficult for smooth and easy discharge, can the long-term stasis of blood hinder in interior.On the contrary, pathogenic microorganism enters body of gland on the contrary easily.

Focal inflammation is difficult for diagnosis in the B, prostate, and often due to illness has cicatrix to hold around the kitchen range and lack blood vessel, is the bad reason of Drug therapy.

C, intraprostatic inflammation focus not necessarily communicate with urethra, so inadequate drainage causes inflammation and is difficult for disappearing.

D, prostate and urethra, bladder, seminal vesicle inflammation exist simultaneously, and reciprocal causation presents multiple

2, physiological and pathological factor:

There are three layers of tough and tensile adipose membrane peplos on A, prostate surface, and most antibiotic are difficult to see through peplos and enter in the body of gland.

B, prostatitis focus are often hardened owing to the blood flow plug stagnates, and are unfavorable for drug diffusion.

C, male's sexual excitation are strong, and frequent libido can cause that prostate is congested repeatedly; Unmarried male lacks regular life and can cause prostatic fluid to be difficult to drain regularly, drainage, produces stasis, inflammation.

D, chronic prostatitis are not all to be due to the bacterial infection, the infection that intrusions such as virus, mycete, infusorian, mycoplasma, chlamydia cause and do not have the aseptic prostatitis of any pathogenic microorganism invasion, and antibacterials are invalid to them.

At above problem, the characteristics of the present invention in prescription, dosage form design are as follows just:

1, be main characteristic to invigorate blood circulation, to give birth to liquid, prescription science, determined curative effect.

A, be guide prostatitis urinary system bolt with the blood circulation promoting medicine, strengthening the prostate local blood circulation is the breach, the lappingout compatibility:

Prostatitis is refractory why, this has substantial connection with prostatic specific position and unique texture, it is hidden in man's pelvic cavity deeply, relatively more latent close, there are three layers of tough and tensile peplos its outside, blood circulation is very faint, and general bactericidal antiphlogistic medicine is difficult to penetrate peplos and enters body of gland, does not have the purpose of killing bacteria.Promptly use injection treatment, because body of gland is made up of not connected conduit, medicine is difficult to and the face infiltration; The inflammatory cell that has killed simultaneously can not wash away external by relatively poor blood circulation, often forms " refuse " and piles up.Therefore, the most obstinate of chronic prostatitis.

Treatment prostatitis the biggest problem is that promptly the circulation of capsula prostatica inner blood is relatively poor, general antibiotic medicine is difficult to enter body of prostate and does not reach effective treatment concentration, and " prostatitis urinary system bolt " is the monarch drug blood circulation promoting medicine based on Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae, substantially improve whole circulation of prostate and local circulation, and the medicine of taking capacity penetrates peplos rapidly, directly act on body of prostate, carry out anti-inflammation and sterilization completely.

B, at the ducts of prostate gland of prostate perimeter region and urethra at right angles or diagonal enter urethra, secretions is difficult for smooth and easy discharge, can the long-term stasis of blood hinder in interior pathogenic principle, compositions such as prostatitis urinary system bolt utilization Cortex Phellodendri, water is strengthened in nourishing kidney, increase the prostatic secretion total amount, play the effect of " canal is washed in water-retention " dredging prostate pipeline.

Like this, suppository of the present invention melts the medicine and the one of the strong water of blood circulation promoting medicine+nourishing kidney, relieving constipation diuresis+anti-inflammatory analgetic, quickens to drain, and the inflammatory cell that kills and refuse is washed away to urethra excrete, and reaches thorough therapeutic purposes.

The selected medicine elite of clock surplus Chinese medicine suppository of the present invention includes 10

With Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing

With Sanguis Draxonis, breast do not have, Moschus is the analgesic therapy of ministerial drug eliminating stagnation, the detumescence sensible

With Cortex Phellodendri for rushing down the usefulness of damp-heat in lower-JIAO poison heresy clearly

With Borneolum Syntheticum have one's ideas straightened out refreshment, clearing away heat to alleviate pain

More than all medicines, compatibility is rigorous rationally, is solvent in conjunction with Adeps caprae seu ovis, gathers the effect of blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, anti-inflammatory analgetic, diuresis promoting altogether.

2, fully use prostate to enrich and penetration near rectal wall place blood capillary, lymphatic vessel, " rectally (anum administration) directional strength is treated the advantage of various prostatosis in performance.

Prostate and rectum are closely adjacent, and middle only have a very thin capillary layer of one deck, and body of prostate is apart from anus 5cm only, because this advantage in geography, rectal treatment prostate is that three big advantages are arranged,

A, help the osmotic absorption nearby of medicine;

B, while medicine absorb by rectum, without inside of human body stomach, intestinal, liver, kidney organ's metabolic conversion, the side effect of not only having avoided long-term oral drugs to produce inner internal organs such as stomach, intestinal, liver, kidney, the disadvantage that the efficacy of a drug, drug effect weaken when also having overcome medicine and reaching prostate focus position after through other organs, blood vessel metabolism.

C, meet the prostate physiological characteristics: after having avoided general water soluble drug to absorb through stomach, intestinal, liver, kidney, reach lesions position through blood circulation just now, and the effective ingredient of medicine combines with plasma protein rapidly in blood circulation, loss is melted in whole blood circulation, and prostate volume is little, reaches the shortcoming of prostatic blood medicine insufficient total amount after the circulation.

3, break through the shortcoming of traditional prostate treatment medicine and general anal orifice and rectal intestine bolt, plaster, innovation and application medicine for prostate disease absorption enhancer-liposoluble substance strengthens the absorption dynamics of prostate for medicine.

The prostatitis disease often occurs in isthmus prostatae and the prostate left and right sides lateral lobe nearest apart from urethra, want to make the medicine performance that acts on prostate inside to render a service, want thing not only will make medicine penetrate capsula prostatica, more will make it finally to reach middle period and left and right sides leaf disease and become the position.And dissect according to prostate, we know that the prostate periphery is wrapped in one deck fibrous capsule and smooth muscle peplos, the existence of this layer adipose membrane makes general water soluble drug be difficult to penetrate.Tradition antibacterial-anti-inflammatory drug and general undressed Chinese herbal medicine are water solublity, water-soluble substances can penetrate the prostate peplos, and to enter the intravital drug level of prostate all be very little, fat-soluble active substance and capsula prostatica have certain affinity, cosolvency, be very easy to directly penetrate the prostate peplos, infiltrate in the body of prostate.And prostatitis urinary system bolt, the water-soluble substrate that is different from traditional prostate treatment medicine and general anal orifice and rectal intestine bolt, plaster, innovation and application medicine for prostate disease absorption enhancer---with the Adeps caprae seu ovis is the substrate solvent, affine for a long time by ingredient and Adeps caprae seu ovis, make the medium-height grass the effective elements of the medicine under the leading of liposoluble substance, the outer adipose membrane of infiltration prostate, the inner diseased region of easier arrival prostate.

4, urinary system bolt in prostatitis adapts to diseases such as various acute and chronic prostatitis, prostate hyperplasia, hypertrophy prostatodynia and damp invasion of lower energizer, gynecology colpitis, cervical erosion

The treatment mechanism of different pharmaceutical dosage form is different.Prostatitis urinary system bolt is not simple antibiotics germ killing drugs in treatment lysis, it is to use the treatment principle of traditional Chinese medical science blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, anti-inflammatory analgetic, diuresis promoting to carry out the refining suppository that forms of scientific composition, so its sphere of action is wider, not only to acute and chronic prostatitis, and the equal blood stasis of disease such as prostate hyperplasia, hypertrophy prostatodynia and damp invasion of lower energizer, gynecology colpitis, cervical erosion, damp and hot poly-, inflammation, the sufferings etc. of accumulateing are all had good therapeutical effect, be the variation of treatment prostatosis cause of disease, complicated choice drug.

Claims (1)

1, the prostatitic rectally liposoluble of a kind of treatment Chinese medicine suppository, it is characterized in that: 2 parts of Adeps caprae seu ovis 15-20 of Radix Salviae Miltiorrhizae 10-30 part Radix Paeoniae Rubra 10-16 part Herba Taraxaci 10-16 part Herba Violae 10-16 part Sanguis Draxonis 2-4.6 part Cortex Phellodendri 10-16 part Olibanum Myrrha 1 part of Borneolum Syntheticum of each 2-4.6 part Moschus part prescription, above-mentioned every kind of composition is carried out after Chinese medicine is processed into fluid extract dry powder according to the predetermined weight umber, form the fat-soluble suppository pharmaceutical dosage form of rectal.