CN116098225A - Functional food for curing chronic colitis - Google Patents

Abstract

The invention relates to a functional food for curing chronic colitis, which belongs to the field of non-drug therapy and biotechnology for life health maintenance and diseases, and aims at solving the problem of chronic colitis which is difficult to cure for a long time. The functional food has cure effect on chronic colitis, is prepared by constructing a high-efficiency fermentation probiotic population of the arrow according to the principle that the effect can be obviously improved by traditional Chinese medicine fermentation, preferably lactobacillus acidophilus, bifidobacterium lactis, bifidobacterium bifidum and streptococcus thermophilus, through optimizing a formula and a biological fermentation process, and the probiotic population is greatly proliferated while being fermented, so that a large number of specific various bioactive functional factors are produced; grinding fresh stem and leaf into slurry, adopting solid state fermentation, drying, preparing into superfine powder, adding auxiliary materials of Chinese olive, pine nut powder and the like, preparing into candy tabletting, and proved by clinical evidence, the food therapy effect on chronic colitis is very remarkable.

Description

Functional food for curing chronic colitis

Technical Field

The invention belongs to the field of non-drug therapies and biotechnology for health maintenance and disease, and aims to solve the problem of chronic colitis which is difficult to cure for a long time. In the process of using food therapy to treat excessive syndrome lead-removing functional food for eight years, the efficacy of the kilodin functional food on chronic colitis is unexpectedly discovered. The archery raw material is rich in Vc, flavonoid, chlorophyll, lupeol, betulin, pentacyclic triple-paste compound, beta sitosterol and other bioactive components, and according to the principle that the effect and the efficacy of traditional Chinese medicine fermentation can be obviously improved, a probiotic dominant population is preferably and constructed, and fresh stems and leaves are cleaned, polished, broken into pulp and fermented. The probiotic bacteria group is greatly proliferated during fermentation, and a great number of specific multiple bioactive functional factors are respectively produced; secondly, the absorption rate, the utilization rate and the action efficacy of the bioactive components can be obviously improved; and thirdly, drying, and preparing the dried product into superfine powder serving as a raw material of the disease-resistant anti-inflammatory preparation for human or animals.

Background

Chronic colitis is broadly defined as chronic colitis (chronic colitis), which is a chronic, recurrent, multiple inflammatory edema, ulceration, hemorrhagic lesions of the intestinal tract caused by various pathogenic causes. In a narrow sense, ulcerative colitis. The pathogenesis is not completely clear, and the lesions are limited to mucous membranes and submucosa, and the common parts are sigmoid colon, rectum and even the whole colon. The disease is characterized by long course of disease, chronic recurrent attacks, abdominal pain and diarrhea as main characteristics, and mucous stool, constipation or diarrhea alternately occur, are good and bad in time, are continuous and are broken in time, and can be seen at any age. Common etiologies are related to infection, immunity, hereditary, food allergy, mental factors, etc.; the common symptoms are abdominal pain and diarrhea, and mucous stool, constipation or diarrhea are alternated. Chronic colitis has a complex etiology, the most common etiology being nonspecific colitis, such as irritable bowel syndrome, inflammatory bowel disease, intestinal dysbacteriosis, small intestinal malabsorption, etc.

Chronic colitis is generally considered to be associated with infection, immune inheritance, environmental, food allergy, defensive dysfunction and mental factors. Allergic factors: allergic lesions are affected by individual differences. Mainly intestinal allergies, occasionally affecting the skin. Some people are allergic to high protein foods such as fish, shrimp, crab, cow milk and the like, and a great amount of histamine substances are generated by the foreign proteins entering the human body to cause allergic reaction. Allergic reaction is a reaction caused by stimulation of an allergic substance and autoimmunity, and a large amount of immune cells are stimulated to aggregate and accumulate on the surface of the mucous membrane of the digestive tract, so that inflammation such as edema, congestion and seepage of the mucous membrane surface is caused. The antibiotics can control the illness state and the treatment effect to different degrees every time the illness happens, which indicates that the illness has pathogenic bacteria effect.

Abuse of antibiotics, resulting in dysbacteriosis of the intestinal tract, or the appearance of enteritis caused by antibiotic-resistant strains. Clinical manifestations of chronic diarrhea: the diarrhea degree is different, the diarrhea of the patient is 3 to 4 times per day, or diarrhea and constipation occur alternately; the weight of the patient can be increased every 1-2 hours. Some patients may have nocturnal diarrhea or postprandial diarrhea. When the rectum is severely affected, a feeling of heavy sensation after tenesmus may occur. The manure is pasty and mixed with a large amount of mucus, even with purulent blood. Repeated abdominal pain: most of the abdominal pain is chronic, light and heavy, sometimes before diarrhea, and sometimes accompanied by symptoms such as fever, nausea, abdominal distention, anorexia, etc., and the abdominal pain can be periumbilical or left lower abdomen. Other manifestations: the colon part is often tender during abdominal examination during the active period of the disease. Symptoms of acute abdomen may be accompanied by fever and borborygmus, especially in cases of acute onset or outbreak.

Treatment has long been without a good method of radical cure. The conventional therapy mainly adopts the functions of protecting gastric mucosa, resisting pathogens, eliminating enterotoxins, symptomatic treatment, preventing relapse and the like. The chronic stage is mainly conservative treatment, and surgical operation treatment can be adopted for cases with explosive or poor internal medicine treatment effect. The Chinese medicine is based on diagnosis and treatment, and has the functions of replenishing qi to invigorate the spleen, excreting dampness and stopping diarrhea. The recipe is modified by Shenling Baizhu Wan or Sili Tang and Sishen Tang. Western medicine treatment, medical treatment, bed rest and systemic support treatment include fluid and electrolyte balance, especially potassium supplementation, and hypokalemia should be corrected. Etiology treatment, anti-infective drug: according to the bacteria culture and the bacteria drug sensitivity test, the anti-infective drug aiming at pathogenic bacteria is selected. Meanwhile, intestinal flora regulating drugs such as bifidobacterium live bacteria preparation, bifidobacterium triple live bacteria preparation, lactobacillus and the like are also put in. Five flowers and eight doors are in paradox. It is difficult to obtain an ideal therapeutic effect.

"Qingjian" is a whole herb of the plant Mesona filifolia belonging to the family Acanthaceae, the academy of crocodile. The Chinese medicine composition has the effects of clearing heat, promoting diuresis, promoting blood circulation and relaxing tendons and is used for treating damp-heat jaundice, rheumatalgia, irregular menstruation, traumatic injury, fracture and the like. Widely distributed in tropical or subtropical areas such as Hainan, yunnan, guangdong and southeast Asia in China. The names of the places are different: yunnan-Xiaojiegu, jiangwang, hainan-Clinopodium polycephalum, guangdong-Zhuye, southeast Asia-Kaempferia galanga. The Chinese people in some areas such as Yunnan, hainan and Guangdong use the Chinese medicine as a nontoxic wild vegetable, and partial folk doctors use the Chinese medicine for treating difficult and complicated diseases such as nephropathy and cancer. In recent years, research shows that the archery is rich in anti-inflammatory, antiviral, antioxidant and antitumor active ingredients, and animal experiments prove that the archery has definite efficacy.

In recent years, due to environmental pollution, harmful chemical poison residues of food and other factors, human immunity is low, chronic colitis and other diseases are continuously increased, and in order to seek an effective control method, we verify various diet therapy effects of the archery biological fermentation functional food from two aspects of cell level and animal experimental model.

Research shows that the archery has the characteristics of enriching and synthesizing nutritional and medicinal active ingredients such as flavonoids, lupeol, betulin, pentacyclic triple-paste compound, chlorophyll, beta sitosterol and the like. However, it is only in the approximately wild conditions, i.e. in the humid forest soil rich in humus, that it is possible to synthesize these active principles. However, with the increase of cognitive population and the expansion of market, wild archery has failed to meet the increasing market demand. Therefore, the research and development team creates a wild-like planting method in 2017, and the content of medicinal active substances such as flavonoids, anthocyanin and the like of the cultivated green arrow is far higher than that of the field planting green arrow through detection.

As is well known, the traditional Chinese medicine fermentation technology is a hot spot which is rising in recent years, and researches show that the traditional Chinese medicine fermentation can improve the action and efficacy by 4-28 times, which is closely related to the selected fermentation strain. For many years, we have preferably constructed a probiotic population with efficient fermentation function, bifidobacterium lactis (JYBR-190), bifidobacterium bifidum (BB-20) and streptococcus thermophilus (STN 26), and experiments show that the content of active substances such as flavonoid, anthocyanin and the like contained in the fermented product of the arrow can be increased by 11-15 times at most. The bifidobacterium lactis has the important function of improving the product to remove heavy metals in the body; bifidobacterium bifidum has the unique functions of enhancing the product, improving the skin quality and reducing the color spots; streptococcus thermophilus has effect in improving uric acid reduction.

Disclosure of Invention

Aiming at the bottleneck problem that chronic colitis is difficult to cure, the invention adopts functional food to carry out dietary therapy, thereby obtaining good cure effect. In the process of dispelling lead in functional food, the medicine has good cure effect on chronic colitis. Thus, by optimizing the formula and the biological fermentation process, according to the principle that the traditional Chinese medicine fermentation can obviously improve the action and efficacy, bifidobacterium lactis, bifidobacterium bifidum and streptococcus thermophilus are preferably selected, the method is used for constructing a high-efficiency fermentation probiotic population of the arrow, grinding fresh stems and leaves into slurry, drying after solid fermentation, preparing into superfine powder, adding auxiliary materials such as Chinese olive, pine nut powder and the like, preparing into candy tabletting, and clinical evidence shows that the diet therapy effect on chronic colitis is quite obvious, the treatment course is different according to the severity of illness, and is generally 6-10 months.

Claims (5)

1. The method of claim 1, wherein the green arrow (academic crocodile) is selected from the green arrow with wild-like planting, and the fresh and tender stem and leaf are cleaned. (1) Slightly drying, placing into a closed sterile container, adding the constructed probiotic bacterial group (bifidobacterium lactis (JYBR-190), bifidobacterium longum (JBLC-141) and streptococcus thermophilus STN 26), and fermenting for 1-2 weeks for later use; (2) drying, grinding and breaking the wall into superfine powder for later use; (3) Adding adjuvants such as fructus Canarii albi and semen Pini powder, making into candy tablet, packaging, and warehousing:

selecting wild-like planted green arrow, cleaning fresh and tender stems and leaves, and preserving for later use;

step two, preferably and constructing a fermentation probiotic population, and preparing liquid seeds;

step three, fermenting the green arrow: solid state biological fermentation;

step four, drying and grinding the archery and breaking the wall to prepare superfine powder;

and fifthly, evaluating the dietary therapy effect of the colonitis.

2. Taking the liquid seed of the probiotic bacterial group, and culturing for 24 hours at 37 ℃ for later use.

3. Selecting fresh and tender stems and leaves of wild-like planted archery, cleaning, slightly drying, placing into a closed container, adding the constructed probiotic population, uniformly stirring, and fermenting at 28 ℃ for 1-2 weeks. The color and smell are observed, the color is normally yellowish green, the wine is slightly fragrant, the fermentation is stopped, and the sterile storage is carried out for standby.

Drying at 4.39 ℃, pulping and breaking the wall to prepare superfine powder for standby; adding fructus Canarii albi and semen Pini powder, making into tablet, packaging, and warehousing.

5. The functional food has obvious dietary therapy cure effect on acute and chronic colitis.