CN116096882A - 用于合成核酸的可重复使用的起始子 - Google Patents
用于合成核酸的可重复使用的起始子 Download PDFInfo
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- CN116096882A CN116096882A CN202180039885.4A CN202180039885A CN116096882A CN 116096882 A CN116096882 A CN 116096882A CN 202180039885 A CN202180039885 A CN 202180039885A CN 116096882 A CN116096882 A CN 116096882A
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- nucleotide
- modified
- group
- deoxyguanosine
- oligonucleotide
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- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 229950010342 uridine triphosphate Drugs 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/841,214 US11384377B2 (en) | 2013-04-02 | 2020-04-06 | Reusable initiators for synthesizing nucleic acids |
| US16/841,214 | 2020-04-06 | ||
| PCT/US2021/025918 WO2021207158A1 (fr) | 2020-04-06 | 2021-04-06 | Initiateurs réutilisables pour la synthèse d'acides nucléiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116096882A true CN116096882A (zh) | 2023-05-09 |
Family
ID=78023444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180039885.4A Pending CN116096882A (zh) | 2020-04-06 | 2021-04-06 | 用于合成核酸的可重复使用的起始子 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4133070A1 (fr) |
| JP (1) | JP2023521704A (fr) |
| CN (1) | CN116096882A (fr) |
| AU (1) | AU2021252542A1 (fr) |
| CA (1) | CA3179701A1 (fr) |
| WO (1) | WO2021207158A1 (fr) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872244A (en) * | 1994-09-02 | 1999-02-16 | Andrew C. Hiatt | 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds |
| US8808989B1 (en) * | 2013-04-02 | 2014-08-19 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acids |
-
2021
- 2021-04-06 EP EP21785385.2A patent/EP4133070A1/fr active Pending
- 2021-04-06 WO PCT/US2021/025918 patent/WO2021207158A1/fr unknown
- 2021-04-06 CA CA3179701A patent/CA3179701A1/fr active Pending
- 2021-04-06 AU AU2021252542A patent/AU2021252542A1/en active Pending
- 2021-04-06 CN CN202180039885.4A patent/CN116096882A/zh active Pending
- 2021-04-06 JP JP2022560973A patent/JP2023521704A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4133070A1 (fr) | 2023-02-15 |
| AU2021252542A1 (en) | 2022-11-10 |
| WO2021207158A1 (fr) | 2021-10-14 |
| JP2023521704A (ja) | 2023-05-25 |
| CA3179701A1 (fr) | 2021-10-14 |
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