CN116077361A - Composition with deep skin cleaning effect, preparation method and application - Google Patents
Composition with deep skin cleaning effect, preparation method and application Download PDFInfo
- Publication number
- CN116077361A CN116077361A CN202310203385.0A CN202310203385A CN116077361A CN 116077361 A CN116077361 A CN 116077361A CN 202310203385 A CN202310203385 A CN 202310203385A CN 116077361 A CN116077361 A CN 116077361A
- Authority
- CN
- China
- Prior art keywords
- composition
- deep skin
- humectant
- combination
- skin cleansing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 86
- 230000000694 effects Effects 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000004140 cleaning Methods 0.000 title abstract description 37
- 239000002101 nanobubble Substances 0.000 claims abstract description 44
- 239000003906 humectant Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000043 antiallergic agent Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 20
- 239000003381 stabilizer Substances 0.000 claims description 28
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 24
- 239000002537 cosmetic Substances 0.000 claims description 18
- 239000000230 xanthan gum Substances 0.000 claims description 17
- 229920001285 xanthan gum Polymers 0.000 claims description 17
- 235000010493 xanthan gum Nutrition 0.000 claims description 17
- 229940082509 xanthan gum Drugs 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 claims description 16
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 16
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 16
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 16
- 239000006071 cream Substances 0.000 claims description 13
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 12
- 229960000458 allantoin Drugs 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 11
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 8
- 239000011159 matrix material Substances 0.000 claims description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 8
- 206010070834 Sensitisation Diseases 0.000 claims description 7
- 230000001815 facial effect Effects 0.000 claims description 7
- 239000000341 volatile oil Substances 0.000 claims description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 239000002826 coolant Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- 229940041616 menthol Drugs 0.000 claims description 6
- 230000003750 conditioning effect Effects 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 4
- 108010058643 Fungal Proteins Proteins 0.000 claims description 4
- 244000246386 Mentha pulegium Species 0.000 claims description 4
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 4
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 4
- KNVPMEZIMFVWMD-UHFFFAOYSA-N Menthyl pyrrolidone carboxylate Chemical compound CC(C)C1CCC(C)CC1OC(=O)N1C(=O)CCC1 KNVPMEZIMFVWMD-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 241000220317 Rosa Species 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- 235000001050 hortel pimenta Nutrition 0.000 claims description 4
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 4
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 4
- -1 menthol amide Chemical class 0.000 claims description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 229940032094 squalane Drugs 0.000 claims description 4
- 239000000516 sunscreening agent Substances 0.000 claims description 4
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 3
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 3
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 3
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 3
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 3
- 240000005385 Jasminum sambac Species 0.000 claims description 3
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 3
- 244000284012 Vetiveria zizanioides Species 0.000 claims description 3
- 235000007769 Vetiveria zizanioides Nutrition 0.000 claims description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 3
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 3
- 229940036350 bisabolol Drugs 0.000 claims description 3
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 3
- 229940106189 ceramide Drugs 0.000 claims description 3
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 3
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 3
- 229920001992 poloxamer 407 Polymers 0.000 claims description 3
- 229940044476 poloxamer 407 Drugs 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 2
- 229940031723 1,2-octanediol Drugs 0.000 claims description 2
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims description 2
- 108010087806 Carnosine Proteins 0.000 claims description 2
- 235000005979 Citrus limon Nutrition 0.000 claims description 2
- 244000131522 Citrus pyriformis Species 0.000 claims description 2
- 244000178870 Lavandula angustifolia Species 0.000 claims description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 2
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims description 2
- 229940044199 carnosine Drugs 0.000 claims description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 2
- 239000001102 lavandula vera Substances 0.000 claims description 2
- 235000018219 lavender Nutrition 0.000 claims description 2
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 2
- 235000021317 phosphate Nutrition 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims 2
- 239000007788 liquid Substances 0.000 abstract description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 5
- 230000008859 change Effects 0.000 abstract description 4
- 239000003344 environmental pollutant Substances 0.000 abstract description 4
- 150000002500 ions Chemical class 0.000 abstract description 4
- 231100000719 pollutant Toxicity 0.000 abstract description 4
- 230000001590 oxidative effect Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 11
- 208000003251 Pruritus Diseases 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000004094 surface-active agent Substances 0.000 description 7
- 241000700198 Cavia Species 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 229960001660 histamine phosphate Drugs 0.000 description 5
- ZHIBQGJKHVBLJJ-UHFFFAOYSA-N histamine phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.NCCC1=CNC=N1 ZHIBQGJKHVBLJJ-UHFFFAOYSA-N 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000000548 hind-foot Anatomy 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 3
- 230000008034 disappearance Effects 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 244000021150 Orbignya martiana Species 0.000 description 2
- 235000014643 Orbignya martiana Nutrition 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 208000014085 Chronic respiratory disease Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 231100000046 skin rash Toxicity 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- OGHHRQHVHVXVPN-UTLKBRERSA-M sodium;(4s)-4-amino-5-dodecanoyloxy-5-oxopentanoate;propane-1,2,3-triol Chemical compound [Na+].OCC(O)CO.CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O OGHHRQHVHVXVPN-UTLKBRERSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a composition with a deep skin cleaning effect, a preparation method and application thereof, wherein the composition with the deep skin cleaning effect comprises nano bubble water, a humectant and an anti-allergic agent, and the diameter of bubbles in the nano bubble water is 20-800nm. The nanometer bubble water, the humectant and the anti-allergic agent are creatively used for preparing the composition with the deep skin cleaning effect, wherein micro-nanometer bubbles in the nanometer bubble water can be broken or contracted in the use process of a user, and the strong change can release energy accumulated by high-concentration positive and negative ions on a gas-liquid interface at the moment, so that a large amount of hydroxyl free radicals are generated, and the pollutant on the skin surface can be removed due to the strong oxidizing property of the hydroxyl free radicals; meanwhile, the humectant and the anti-allergic agent can ease the skin, so that the composition containing the nano bubble water, the humectant and the anti-allergic agent can achieve the effect of gently and deeply cleaning the skin.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to a composition with a deep skin cleaning effect, a preparation method and application thereof.
Background
With the improvement of living standard, people are more and more concerned about the health and beauty of facial skin, especially for girls loving beauty, and the cleaning and maintenance of facial skin are very important. At present, a plurality of cleaning cosmetics such as facial cleanser, bath lotion and the like are on the market, most of the formulations contain surfactants, are easy to remain on the skin to cause skin damage, have poor biodegradability and can cause irreversible influence on the environment.
Nanobubbles are bubbles having a diameter of 1 micron or less, and are also called "ultrafine bubbles". There are two basic types, one is a non-spherical interface nanobubble, a bubble that is fixedly distributed on the interface of liquid and solid; the other is spherical nanobubbles suspended in a liquid. When the micro-nano bubbles shrink and collapse, the severe change caused by the disappearance of the gas-liquid interface releases the energy accumulated by the high-concentration positive and negative ions on the interface, a large amount of hydroxyl free radicals are generated, and the strong oxidability of the hydroxyl free radicals can remove pollutants. The period of the existence of the nanobubbles is uncertain, and many influencing factors such as particle size, zeta potential, salt ion concentration, interface charge and the like are included. Zeta potential is a key factor in nanobubble stabilization.
CN115297956a discloses cosmetics containing nanobubble liquid and cosmetic ingredients. The cosmetic comprises a nano bubble liquid and cosmetic components, wherein the nano bubble liquid is a solution in a nano bubble state containing a liquid medium and bubbles, and the diameters of the bubbles are in the range of 5-500 nm. The product can promote blood flow, and has effects of moistening skin.
CN113893187a discloses a whitening and spot-fading spray, which comprises the following raw materials in weight ratio: nano bubble small molecule water, chitosan and vitamin C. The whitening and freckle-removing spray provided by the invention can increase the absorption of vitamin C, so that the brittleness of capillaries is reduced, and the organism resistance is improved.
Therefore, it is very necessary to develop a cosmetic having multiple effects of environmental friendliness, mild and non-irritating skin application, novel formulation, stable transportation, and the like.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a composition with a deep skin cleaning effect, a preparation method and application.
To achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a composition with deep skin cleansing effect comprising nanobubble water, humectant and anti-sensitizer, wherein the diameter of the bubbles in the nanobubble water is 20-800nm.
Specific values in the range of 20-800nm may be selected from 20nm, 200nm, 300nm, 400nm, 500nm, 600nm, 700nm, 800nm, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
The nanometer bubble water, the humectant and the anti-allergic agent are creatively used for preparing the composition with the deep skin cleaning effect, and the diameters of bubbles in the nanometer bubble water are 20-800nm. In the use process of a user, micro-nano bubbles in nano bubble water can be broken or contracted, and the strong change can release energy accumulated by high-concentration positive and negative ions on a gas-liquid interface at the moment, so that a large amount of hydroxyl free radicals are generated, and the pollutants on the surface of the skin can be removed due to the strong oxidizing property of the hydroxyl free radicals; meanwhile, the humectant and the anti-allergic agent can ease the skin, so that the composition containing the nano bubble water, the humectant and the anti-allergic agent can achieve the effect of gently and deeply cleaning the skin.
The skin cleaning effect of the composition with the deep skin cleaning effect is better than that of a face cleaning product containing a surfactant, and the problem of poor biodegradability of the surfactant is avoided. In addition, the cleaning power of the composition is stronger when the bubble diameter in the nanobubbles is in the range of 20-800nm.
Preferably, the composition having deep skin cleansing efficacy further comprises any one or a combination of at least two of an antioxidant, a fragrance, a cooling agent, or a skin conditioning agent; the combination of at least two of the above-mentioned components includes a combination of an antioxidant and a fragrance, a combination of an antioxidant and a cooling agent, or a combination of a cooling agent and a skin conditioning agent, etc., and any other combination may be selected, and will not be described in detail herein.
Preferably, the humectant comprises any one or a combination of at least two of glycerol, trehalose, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, or octanediol; the at least two combinations include a combination of glycerin and trehalose, a combination of glycerin and butanediol, or a combination of butanediol and 1, 2-pentanediol, etc., and any other combination manner may be selected, so that no further description is given here.
Preferably, the anti-sensitization agent comprises allantoin and/or dipotassium glycyrrhizinate.
Preferably, the anti-sensitization agent comprises allantoin and dipotassium glycyrrhizinate.
Allantoin is an amphoteric compound, can be combined with various substances to form double salts, has the effects of relieving pain, resisting inflammation and oxidation, keeping skin moisture, moistening and softening, is a specific additive for cosmetics such as cosmetology and hairdressing, and is widely used in the aspects of freckle cream, acne liquid, shampoo, soap, toothpaste, shave lotion, hair conditioner, astringent, sweat-resistant deodorant lotion and the like.
Dipotassium glycyrrhizinate can accelerate skin absorption of cosmetic effective components, and can be used for preventing sunburn, whitening skin, relieving itching, regulating sebum, promoting hair growth, caring hair, etc. Can be used for preventing dermatitis, xerosis cutis, sunburn, and skin rash.
When the anti-allergic agent comprises allantoin and/or dipotassium glycyrrhizinate, the composition with the deep skin cleaning effect has good anti-inflammatory and relieving effects; the skin soothing effect of the composition with deep skin cleansing efficacy is further enhanced when the anti-sensitization agent comprises a combination of allantoin and dipotassium glycyrrhizinate.
Preferably, the antioxidant comprises any one or a combination of at least two of squalane, tocopheryl acetate, p-hydroxyacetophenone, or bisabolol; the at least two combinations include a combination of squalane and tocopherol acetate, a combination of squalane and p-hydroxyacetophenone, or a combination of p-hydroxyacetophenone and bisabolol, etc., and any other combination manner may be selected, and will not be described in detail herein.
Preferably, the aromatic comprises any one or a combination of at least two of peppermint essence, jasmine essence, rose essence, vetiver essential oil, lemon essential oil or lavender essential oil; the combination of at least two kinds of the above-mentioned components includes combination of peppermint essence and jasmine essence, combination of peppermint essence and rose essence or combination of rose essence and vetiver essential oil, etc., and other arbitrary combination modes can be selected, so that the above-mentioned components will not be repeated here.
Preferably, the cooling agent comprises any one or a combination of at least two of menthyl lactate, menthyl pyrrolidone carboxylate, menthol or menthol amide; the at least two combinations include a combination of menthyl lactate and menthyl pyrrolidone carboxylate, a combination of menthyl pyrrolidone carboxylate and menthol, a combination of menthol and menthyl lactate, etc., and any other combination mode may be selected, and will not be described in detail herein.
Preferably, the skin conditioning agent comprises any one or a combination of at least two of ceramide, nicotinamide, hydrolyzed yeast protein, ethylhexyl glycerol, or carnosine; the at least two combinations include a combination of ceramide and nicotinamide, a combination of nicotinamide and hydrolyzed yeast protein, or a combination of hydrolyzed yeast protein and ethylhexyl glycerol, etc., and any other combination manner may be selected, and will not be described in detail herein.
Preferably, the mass ratio of the humectant to the anti-allergic agent is (5-20): 0.5-5.
The specific values in (5-20) may be selected from 5, 7, 9, 11, 13, 15, 17, 19 or 20, etc.;
the specific value in (0.5-5) may be selected from 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
Preferably, the nanobubble water preparation raw material comprises water and a bubble stabilizer.
Preferably, the bubble stabilizer comprises any one or a combination of at least two of poloxamer 407, hydroxypropyl starch phosphate, xanthan gum or hydroxypropyl methylcellulose; the at least two combinations include a combination of poloxamer 407 and hydroxypropyl starch phosphate, a combination of hydroxypropyl starch phosphate and xanthan gum, or a combination of xanthan gum and hydroxypropyl methylcellulose, etc., and any other combination modes may be selected, so that no further description is given here.
Preferably, the bubble stabilizing agent comprises xanthan gum and/or hydroxypropyl methylcellulose.
Preferably, the bubble stabilizer comprises xanthan gum and hydroxypropyl methylcellulose.
When the bubble stabilizer comprises xanthan gum and/or hydroxypropyl methyl cellulose, the composition with deep skin cleaning effect has the advantages of large quantity of nano bubbles, high absolute value of Zata potential and long residence time, and further has the advantages of dense foam, stable system and strong cleaning effect; when the bubble stabilizer includes xanthan gum and hydroxypropyl methylcellulose, the composition having deep skin cleansing effect has more and stable nanobubbles and a stronger skin cleansing effect.
Preferably, the mass ratio of the bubble stabilizer, the humectant and the anti-allergic agent is (1-20): 5-20): 0.5-5.
The specific values in (1-20) may be 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 or 20, etc.;
the specific values in (5-20) may be selected from 5, 7, 9, 11, 13, 15, 17, 19 or 20, etc.;
the specific value in (0.5-5) may be selected from 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
When the mass ratio of the bubble stabilizer to the humectant to the anti-allergic agent is (1-20): 5-20): 0.5-5, the composition has more excellent skin cleaning effect.
In a second aspect, the present invention provides a method for preparing a composition having deep skin cleansing efficacy according to the first aspect, the method comprising the steps of:
(1) Mixing water, humectant and antiallergic agent to obtain matrix composition;
(2) Treating the matrix composition produced in step (1) using a hydrodynamic cavitation device to produce the composition having deep skin cleansing efficacy.
The preparation method of the composition provided by the invention is simple in process and easy to be industrially amplified, and only needs to mix water, humectant and anti-allergic agent and then treat the mixture by using a hydrodynamic cavitation device.
Preferably, a bubble stabilizer is also added during the mixing in the step (1);
preferably, the temperature during the mixing in the step (1) is 30-90 ℃, and the mixing time is 15-40min.
Preferably, the temperature of the treatment in the step (2) is 15-40 ℃, and the treatment time is 10-30min.
The specific value of 30-90deg.C can be 30deg.C, 40deg.C, 50deg.C, 60deg.C, 70deg.C, 80deg.C or 90deg.C, etc.;
the specific value of 15-40min can be 15min, 17min, 21min, 25min, 29min, 33min, 37min or 40 min;
the specific value of 15-40deg.C can be 15 deg.C, 20 deg.C, 25 deg.C, 30 deg.C, 35 deg.C or 40 deg.C;
the specific value of the 10-30min can be selected from 10min, 13min, 17min, 21min, 25min, 29min or 30min, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
Preferably, the hydrodynamic cavitation device parameter of step (2) has an inlet pressure of no more than 50mH 2 O；
Said not more than 50mH 2 The specific value of O can be 15mH 2 O、20mH 2 O、25mH 2 O、30mH 2 O、40mH 2 O、45mH 2 O or 50mH 2 O, etc.;
other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
Preferably, kong Naliu speed in the hydrodynamic cavitation device parameter of step (2) is not more than 25m/s.
The specific value of not more than 25m/s may be selected from 7m/s, 10m/s, 13m/s, 16m/s, 19m/s, 22m/s, 25m/s, etc.;
other specific point values within the above numerical ranges are selected, and will not be described here again
In a third aspect, the present invention provides the use of a composition having a deep skin cleansing effect as described in the first aspect or a method of preparation as described in the second aspect for the preparation of a cosmetic.
Preferably, the cosmetic comprises essence, essence cream, facial cleanser, eye cream, face cream, toner, astringent or sunscreen.
The composition with the deep skin cleaning effect or the preparation method thereof can be used for preparing cosmetics, the formulations of the cosmetics can be adjusted according to actual needs, and the formulations can be selected from essence, essence cream, facial cleanser, eye cream, face cream, toner, toning lotion, sun cream and the like.
Compared with the prior art, the invention has the following beneficial effects:
1. the nanometer bubble water, the humectant and the anti-allergic agent are creatively used for preparing the composition with the deep skin cleaning effect, and the diameters of bubbles in the nanometer bubble water are 20-800nm. In the use process of a user, micro-nano bubbles in nano bubble water can be broken or contracted, and the strong change can release energy accumulated by high-concentration positive and negative ions on a gas-liquid interface at the moment, so that a large amount of hydroxyl free radicals are generated, and the pollutants on the surface of the skin can be removed due to the strong oxidizing property of the hydroxyl free radicals; meanwhile, the humectant and the anti-allergic agent can ease the skin, so that the composition containing the nano bubble water, the humectant and the anti-allergic agent can achieve the effect of gently and deeply cleaning the skin.
The skin cleaning effect of the composition with the deep skin cleaning effect is better than that of a face cleaning product containing a surfactant, and the problem of poor biodegradability of the surfactant is avoided. In addition, when the bubble diameter in the nanobubbles is in the range of 20-800nm, the cleaning power of the composition is stronger.
2. The preparation method of the composition provided by the invention is simple in process and easy to be industrially amplified, and only needs to mix water, humectant and anti-allergic agent and then treat the mixture by using a hydrodynamic cavitation device.
3. The composition with the deep skin cleaning effect or the preparation method thereof can be used for preparing cosmetics, and the formulations of the cosmetics can be adjusted according to actual needs, such as essence, essence cream, facial cleanser, eye cream, face cream, toner, toning lotion, sun cream and the like.
Detailed Description
The technical scheme of the invention is further described by the following specific embodiments. It will be apparent to those skilled in the art that the examples are merely to aid in understanding the invention and are not to be construed as a specific limitation thereof.
The procedures, conditions, reagents, experimental methods, etc. for carrying out the present invention are common knowledge and common knowledge in the art, except for those specifically mentioned below, and the present invention is not particularly limited. The experimental methods in each example, in which specific conditions are not noted, are generally performed under conventional conditions or under conditions recommended by the manufacturer.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. However, in case of conflict, the present specification, including definitions, will control.
Trehalose in the following is a product purchased from solebao; allantoin is a product available from Alatin under the number A101660-500 g; hydroxypropyl methylcellulose is a product available from Alatidine under the number H434478-100 g; xanthan gum is a product available from aladine under the number G104873-500G; babassu seed oil glyceryl polyether-8 esters are available from zhu n-thousand biotechnology limited company under the model ZQ-1018.
Example 1
The present embodiment provides a composition having a deep skin cleansing effect, and the preparation method of the composition having a deep skin cleansing effect includes the steps of:
(1) Mixing water, humectant, antiallergic agent and bubble stabilizer, and stirring at 60deg.C for 30min to obtain matrix composition;
(2) Using a nanobubble generator (set parameters: inlet pressure 50 mH) 2 O, in-hole flow rate 25 m/s) at 25℃for 20min, wherein the specific composition and ratio of each component are shown in Table 1.
TABLE 1
Example 2
The present embodiment provides a composition having a deep skin cleansing effect, and the preparation method of the composition having a deep skin cleansing effect includes the steps of:
(1) Mixing water, humectant, antiallergic agent and bubble stabilizer, and stirring at 90deg.C for 15min to obtain matrix composition;
(2) Using a nanobubble generator (set parameters: inlet pressure 40 mH) 2 O, in-hole flow rate of 20 m/s) at 15℃for 30min, wherein the specific composition and ratio of each component are shown in Table 2.
TABLE 2
Example 3
The present embodiment provides a composition having a deep skin cleansing effect, and the preparation method of the composition having a deep skin cleansing effect includes the steps of:
(1) Mixing water, humectant, antiallergic agent and bubble stabilizer, and stirring at 30deg.C for 40min to obtain matrix composition;
(2) Using a nanobubble generator (set parameters: inlet pressure 30 mH) 2 O, in-hole flow rate of 10 m/s) at a temperature of 40℃for 10min, wherein the specific composition and ratio of each component are shown in Table 3.
TABLE 3 Table 3
Example 4
This example provides a composition with deep skin cleansing efficacy which is prepared in a manner different from example 1 only in that the bubble stabilizer does not contain xanthan gum and the mass fraction of xanthan gum is distributed to hydroxypropyl methylcellulose, the remainder being the same as in example 1.
Example 5
This example provides a composition with deep skin cleansing effect, which is prepared by a method differing from example 1 only in that the bubble stabilizer does not contain hydroxypropyl methylcellulose and the mass fraction of hydroxypropyl methylcellulose is distributed to xanthan gum, and the rest is the same as example 1.
Example 6
This example provides a composition with deep skin cleansing effect, which is prepared by a method differing from example 1 only in that the anti-sensitization agent does not contain allantoin and the allantoin is distributed to dipotassium glycyrrhizinate in parts by mass, and the rest is the same as in example 1.
Example 7
This example provides a composition with deep skin cleansing effect, which is different from example 1 only in that the anti-sensitization agent does not contain dipotassium glycyrrhizinate and the dipotassium glycyrrhizinate is distributed to allantoin in parts by weight, and the rest is the same as example 1.
Example 8
This example provides a composition with deep skin cleansing effect, which is prepared by a method differing from example 1 only in that 10 parts of the bubble stabilizer, 20 parts of the humectant and 5 parts of the anti-sensitizer are replaced with 0.6 parts of the bubble stabilizer, 26.8 parts of the humectant and 7.6 parts of the anti-sensitizer (the mass ratio of the bubble stabilizer, the humectant and the anti-sensitizer is about 0.5:21:6), and the rest is the same as example 1.
Example 9
This example provides a composition with deep skin cleansing effect, which is prepared by a method differing from example 1 only in that 10 parts of the bubble stabilizer, 20 parts of the humectant and 5 parts of the anti-sensitizer are replaced with 29 parts of the bubble stabilizer, 5.6 parts of the humectant and 0.4 part of the anti-sensitizer (the mass ratio of the bubble stabilizer, the humectant and the anti-sensitizer is about 21:4:0.3), and the rest is the same as example 1.
Comparative example 1
This comparative example provides a composition with deep skin cleansing efficacy, which is prepared by a method differing from example 1 only in that the matrix composition in step (2) is directly left at 25 ℃ for 20min without treatment with a nanobubble generator, and the rest is the same as example 1.
Comparative example 2
This comparative example provides a sodium lauroyl glutamate glycerol solution with a mass fraction of 0.5%.
Comparative example 3
This comparative example provides a mass fraction of babassu seed oil glycerol polyether-8 ester glycerol solution of 1.2%.
Comparative example 4
This comparative example provides a 2.6% mass fraction sodium myristoyl glutamate glycerol solution.
Test example 1
This test example evaluates the bubble stability of the compositions prepared in examples 1-5.
After the composition prepared in examples 1 to 5 was left for 3 days, it was injected into a model box of a miniscopic observation system, the number of micro-nano bubbles in the visual field was photographed every 1h until the micro-nano bubbles completely disappeared, the time when the micro-nano bubbles completely disappeared was recorded, and the stability time difference rate (%) =a was calculated i /A 1 X 100%, where A 1 For the time of complete disappearance of the micro-nano bubbles of example 1, A i The time for the micro-nano bubbles of the remaining examples to completely disappear.
TABLE 4 Table 4
| Group of | Stability time Difference Rate (%) |
| Example 1 | 100 |
| Example 2 | 89 |
| Example 3 | 97 |
| Example 4 | 49 |
| Example 5 | 61 |
As can be seen from the data in table 4, in example 4 and example 5, compared with example 1, one of the hydroxypropyl methylcellulose and the xanthan gum in the bubble stabilizer is absent, and the stability time difference rate is lower than that of example 1, which indicates that the combination of the hydroxypropyl methylcellulose and the xanthan gum has unexpected synergistic effect in improving the stability of nano bubbles.
Test example 2
The skin cleansing effect was evaluated for the products prepared in each example or comparative example.
The specific evaluation method comprises the following steps:
(1) 130 oily skin volunteers aged between 16 and 65 years were selected. The compositions were randomly divided into 13 groups of 5 females and 5 males (meeting the conditions of no serious systemic disease, no immunodeficiency or autoimmune disease, no serious allergic history on skin care cosmetics, no hormone drugs and immunosuppressants used in the last month, no participation in other clinical trials, etc.).
(2) Skin of volunteers was analyzed using a skin fat content Sebumeter test probe manufactured by Courage+Khazaka, germany (CK, germany) and no cosmetic or external medicine was used 3 days before the subject participated in the test, and before the test, the subject was sat in an atmosphere of 50% at 22℃for 30 minutes, the skin fat content at the intersection of the midline between the brows and a line 1cm from the upper brow edge was measured using a test instrument, and then 1mL of the product prepared in the example or comparative example was applied at this position, and kneaded by massageAfter the product is absorbed for 3min, the product is cleaned by clean water, the test subject is still sitting for 30min in an environment room with the air humidity of 50% at the temperature of 22 ℃, the skin grease content at the same position is measured by a detection instrument again, the test of the same test subject is completed by the same measuring personnel, and the skin grease cleaning rate is calculated. Skin oil cleaning rate (%) = (V) 2 -V 1 )/V 2 ×100％
Wherein V is 1 For skin lipid content after sample application, V 2 The results for the skin lipid content prior to use of the sample are shown in table 5:
TABLE 5
As can be seen from the data in table 5, in example 4 and example 5, compared with example 1, the skin oil cleaning rate of the composition is lower than that of example 1, which indicates that the composition has higher cleaning strength due to the high stability of nanobubbles and the high nanobubble content when the composition contains two components of hydroxypropyl methylcellulose and xanthan gum.
In example 8 and example 9, compared with example 1, the mass ratio of the bubble stabilizer, the humectant and the antiallergic agent is outside the preferred range of (1-20): (5-20): (0.5-5), and the skin oil cleaning rate is lower than that of example 1, which indicates that the cleaning effect of the composition is stronger when the ratio of the three components is in the preferred range;
comparative example 1 compared with example 1, the composition did not contain nanobubbles, and the skin oil cleaning rate was lower than example 1, indicating that nanobubbles in the present invention have a significant cleaning effect.
The comparison examples 2-4 respectively select three surfactants with different components, and the skin grease cleaning rate is lower than that of the example 1, which shows that the composition prepared by the invention has more obvious effect than the interface product containing the surfactant.
Test example 3
The anti-inflammatory and soothing effects of the products prepared in examples 1-3 and 6-7 were evaluated
(1) Taking 60 guinea pigs, wherein the male and female parts are half, and removing hair on the right hind foot before experiment 1d, wherein the hair removing area is about 2cm 2 Guinea pigs were randomly divided into 6 groups, each containing 10 guinea pigs, and recorded as examples 1-3 and 6-7 and blank groups, respectively.
(2) The guinea pigs of the example group and the blank group were continuously 2d coated with 0.05g of the composition prepared in the example at the dehairing point, respectively, and the blank group was coated with an equal amount of deionized water 1 time a day.
(3) On day 3 of the experiment, histamine phosphate solutions of 0.01% (w/v), 0.02% (w/v), 0.03% (w/v), 0.04% (w/v), 0.05% (w/v), 0.06% (w/v), 0.07% (w/v), 0.08% (w/v), 0.09% (w/v), and 0.1% (w/v) were prepared with physiological saline, respectively. The haired area of the right hind paw of the guinea pig was scratched with coarse sand paper to an extent of about 1cm 2 The corresponding composition was applied topically 1 time with an application amount of 0.05g, the blank was applied with an equal amount of deionized water, after 10 minutes, 0.05mL of 0.01% (w/v) histamine phosphate solution was added dropwise to the site of the scratch, and it was observed whether the guinea pig licked the right hind paw within 3 minutes, if not, 0.02% (w/v) histamine phosphate solution was added dropwise to the site of the scratch, and it was observed whether the guinea pig licked the right hind paw within 3 minutes. And so on, increasing the concentration according to the gradient every 3min, and dripping 0.05mL of histamine phosphate solution each time until the guinea pigs lick the right hind feet within 3 min. The average value of the itch causing threshold and the itch causing threshold difference ratio of guinea pigs of the same group were calculated with the cumulative total amount of histamine phosphate added at this time as itch causing threshold (. Mu.g), and the itch causing threshold difference ratio (%) = (test group itch causing threshold-blank group itch causing threshold)/blank group itch causing threshold X100%, and the results are shown in Table 6.
TABLE 6
As is clear from the data in Table 6, in example 6 and example 7, compared with example 1, the anti-allergic agent lacks one of dipotassium glycyrrhizinate and allantoin, respectively, and the difference rate of the itching threshold is lower than that in example 1, which indicates that the two components have synergistic effect in improving the anti-allergic and soothing effects of the skin. The composition of the invention can effectively clean skin and can relieve skin sensitivity.
Test example 4
The safety of the composition prepared in the examples was evaluated. The specific evaluation method comprises the following steps: the test is carried out according to the human skin patch test method in the human body safety test method of the seventh chapter in the cosmetic safety technical Specification 2015 edition. (1) Female volunteers 18-60 years old meeting the experimental requirements were selected, excluding criteria: (a) Antihistamines used in the last week or immunosuppressants used in the last month; (b) Any anti-inflammatory agent is applied to the tested part in the last two months; (c) a subject suffering from a clinically unhealed inflammatory skin condition; (d) insulin dependent diabetes mellitus; (e) Asthma or other chronic respiratory disease patients undergoing treatment; (f) receiving an anti-cancer chemotherapeutic within approximately 6 months; (g) patients with immunodeficiency or autoimmune disease; (h) lactating or pregnant women; (i) Bilateral mastectomy and bilateral axillary lymphadenectomy; (n) affecting the determination of the test result at the skin site due to scars, pigments, atrophy, port-marks or other imperfections; (o) participate in other clinical trial researchers; (p) highly sensitive body constitution; (q) non-volunteer participants or those who were unable to complete the prescribed content as required by the trial. (2) each example corresponds to a group of 10 volunteers; the selected area is not more than 50mm 2 A plaque test apparatus of about 1mm depth. The compositions prepared in the examples were added to the plaque chamber in an amount of about 0.1g. The control wells were empty of any material. The patch test with the test object is applied to the back or forearm of the subject by hypoallergenic tape, and is applied to the skin with palm light pressure for 24 hr. (3) Dividing intoSkin reactions were observed according to the table 7 criteria, as opposed to 30min after removal of the subject plaque tester (after disappearance of the indentations), 24h and 48 h. And evaluated according to the criteria of table 7.
TABLE 7
The results show that the composition prepared by the invention is safe for human body application and is not easy to cause allergic reactions such as erythema, herpes and the like.
The applicant states that the present invention is illustrated by the above examples of the preparation process of the present invention, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be practiced by relying on the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (10)
1. A composition with deep skin cleansing effect, which is characterized by comprising nano bubble water, humectant and anti-sensitizer, wherein the diameter of bubbles in the nano bubble water is 20-800nm.
2. The deep skin cleansing composition of claim 1, further comprising any one or a combination of at least two of an antioxidant, a fragrance, a cooling agent, or a skin conditioning agent;
preferably, the humectant comprises any one or a combination of at least two of glycerol, trehalose, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, or octanediol;
preferably, the anti-sensitization agent comprises allantoin and/or dipotassium glycyrrhizinate;
preferably, the anti-sensitization agent comprises allantoin and dipotassium glycyrrhizinate;
preferably, the antioxidant comprises any one or a combination of at least two of squalane, tocopheryl acetate, p-hydroxyacetophenone, or bisabolol;
preferably, the aromatic comprises any one or a combination of at least two of peppermint essence, jasmine essence, rose essence, vetiver essential oil, lemon essential oil or lavender essential oil;
preferably, the cooling agent comprises any one or a combination of at least two of menthyl lactate, menthyl pyrrolidone carboxylate, menthol or menthol amide;
preferably, the skin conditioning agent comprises any one or a combination of at least two of ceramide, nicotinamide, hydrolyzed yeast protein, ethylhexyl glycerol, or carnosine;
preferably, the mass ratio of the humectant to the anti-allergic agent is (5-20): 0.5-5.
3. The composition with deep skin cleansing effect according to claim 1 or 2, wherein the nano-bubble water preparation raw material comprises water and a bubble stabilizer.
4. A composition having deep skin cleansing efficacy according to claim 3, characterized in that the air bubble stabilizing agent comprises any one or a combination of at least two of poloxamer 407, hydroxypropyl starch phosphate, xanthan gum or hydroxypropyl methylcellulose;
preferably, the bubble stabilizer comprises xanthan gum and/or hydroxypropyl methylcellulose;
preferably, the bubble stabilizer comprises xanthan gum and hydroxypropyl methylcellulose;
preferably, the mass ratio of the bubble stabilizer, the humectant and the anti-allergic agent is (1-20): 5-20): 0.5-5.
5. A method for preparing a composition having deep skin cleansing efficacy according to any of claims 1-4, characterized in that the method comprises the steps of:
(1) Mixing water, humectant and antiallergic agent to obtain matrix composition;
(2) Treating the matrix composition produced in step (1) using a hydrodynamic cavitation device to produce the composition having deep skin cleansing efficacy.
6. The method of preparing a deep skin cleansing composition according to claim 5, wherein a bubble stabilizer is further added during the mixing of step (1);
preferably, the temperature during the mixing in the step (1) is 30-90 ℃, and the mixing time is 15-40min.
7. The method for preparing a composition having a deep skin cleansing effect according to claim 5 or 6, wherein the temperature at the time of the treatment in the step (2) is 15 to 40 ℃ and the treatment time is 10 to 30min.
8. A method for preparing a composition having deep skin cleansing efficacy according to any of the claims 5-7, characterized in that the hydrodynamic cavitation device parameter of step (2) has an inlet pressure of not more than 50mH 2 O；
Preferably, kong Naliu speed in the hydrodynamic cavitation device parameter of step (2) is not more than 25m/s.
9. Use of a composition with deep skin cleansing efficacy according to any one of claims 1 to 4 or a method of preparation according to any one of claims 5 to 8 for the preparation of a cosmetic.
10. The use according to claim 9, wherein the cosmetic comprises a serum, a serum cream, a facial cleanser, an eye cream, a face cream, a toner, a lotion or a sun cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310203385.0A CN116077361B (en) | 2023-03-03 | 2023-03-03 | Composition with deep skin cleaning effect, preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310203385.0A CN116077361B (en) | 2023-03-03 | 2023-03-03 | Composition with deep skin cleaning effect, preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116077361A true CN116077361A (en) | 2023-05-09 |
| CN116077361B CN116077361B (en) | 2023-11-24 |
Family
ID=86187049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310203385.0A Active CN116077361B (en) | 2023-03-03 | 2023-03-03 | Composition with deep skin cleaning effect, preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116077361B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017002020A (en) * | 2015-06-09 | 2017-01-05 | 株式会社ウォーターデザイン | Hydrogenated high viscosity cosmetic and production method |
| JP2017031129A (en) * | 2015-08-05 | 2017-02-09 | 株式会社ウォーターデザイン | Hydrogen-containing liquid aqueous cosmetics and production methods thereof, as well as aerosol products |
| CN112055581A (en) * | 2018-09-21 | 2020-12-08 | 三育大学校产学协力团 | Ultrasound induced drug delivery system using drug carrier comprising nanobubbles and drug |
| CN112175749A (en) * | 2020-10-16 | 2021-01-05 | 上海航翼高新技术发展研究院有限公司 | Micro-nano bubble cleaning agent for airplane and preparation method and application thereof |
| CN114129460A (en) * | 2021-12-07 | 2022-03-04 | 浙江汇商海科技发展有限公司 | Toothpaste containing hydrogen nano bubbles and preparation method thereof |
| CN114560644A (en) * | 2022-03-26 | 2022-05-31 | 中建西部建设北方有限公司 | Modified micro-nano bubble water, preparation method thereof and concrete |
| JP2022103130A (en) * | 2020-12-25 | 2022-07-07 | 三粧化研株式会社 | Nanobubble-containing cosmetic composition |
-
2023
- 2023-03-03 CN CN202310203385.0A patent/CN116077361B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017002020A (en) * | 2015-06-09 | 2017-01-05 | 株式会社ウォーターデザイン | Hydrogenated high viscosity cosmetic and production method |
| JP2017031129A (en) * | 2015-08-05 | 2017-02-09 | 株式会社ウォーターデザイン | Hydrogen-containing liquid aqueous cosmetics and production methods thereof, as well as aerosol products |
| CN112055581A (en) * | 2018-09-21 | 2020-12-08 | 三育大学校产学协力团 | Ultrasound induced drug delivery system using drug carrier comprising nanobubbles and drug |
| CN112175749A (en) * | 2020-10-16 | 2021-01-05 | 上海航翼高新技术发展研究院有限公司 | Micro-nano bubble cleaning agent for airplane and preparation method and application thereof |
| JP2022103130A (en) * | 2020-12-25 | 2022-07-07 | 三粧化研株式会社 | Nanobubble-containing cosmetic composition |
| CN114129460A (en) * | 2021-12-07 | 2022-03-04 | 浙江汇商海科技发展有限公司 | Toothpaste containing hydrogen nano bubbles and preparation method thereof |
| CN114560644A (en) * | 2022-03-26 | 2022-05-31 | 中建西部建设北方有限公司 | Modified micro-nano bubble water, preparation method thereof and concrete |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116077361B (en) | 2023-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108030764B (en) | Double-layer cleansing lotion and preparation method thereof | |
| DE69601755T2 (en) | Stable composition that contains a water-sensitive cosmetic and / or dermatological active ingredient | |
| JP3455218B2 (en) | Cosmetic composition in the form of a water / oil / water ternary emulsion having a gelled external phase | |
| CN108904302A (en) | A kind of fullerene topical composition | |
| EP0095615A2 (en) | Skin conditioning composition | |
| EP1140008A1 (en) | Cosmetic or pharmaceutical gels which contain lecithin, or low viscosity o/w microemulsions which contain lecithin | |
| JP3923226B2 (en) | Topical skin preparation | |
| EP0937453A2 (en) | Cosmetic and tissue cleansing and moisturizing composition | |
| US11260018B2 (en) | Approaches for improving skin hydration and moisturization | |
| US5993857A (en) | Cosmetic skin cleanser based on natural active substances | |
| DE69600753T2 (en) | Stable composition containing an enzyme | |
| CN105796459A (en) | Moisturizing gel containing hydrolyzed pearl powder flexible nano liposome | |
| JPS6127094B2 (en) | ||
| KR20080003918A (en) | Silicone elastomer exfoliting compositions | |
| CN108135790B (en) | Three-phase cleaning composition | |
| JP2007230929A (en) | Face wash for removing horny plug | |
| CN1357321A (en) | Inflammation and red spot reducing method | |
| CN116077361B (en) | Composition with deep skin cleaning effect, preparation method and application | |
| KR20110058240A (en) | Nanoemulsion containing high content of hydrophobic ingredients and the method for preparing thereof | |
| JP6474227B2 (en) | Composition for toiletry products containing plant extract | |
| CN109010105B (en) | Multi-effect composition and preparation method and application thereof | |
| CN1345581A (en) | Additives composition for domestic chemical products, preparation method and application thereof | |
| JPS6112799A (en) | Detergent | |
| Rähse | Design of skin care products | |
| JP2001072574A5 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |