CN116036164A

CN116036164A - Pharmaceutical composition for treating thyroid nodule

Info

Publication number: CN116036164A
Application number: CN202211527804.8A
Authority: CN
Inventors: 路波; 王高雷; 杨栓柱; 肖洋; 成路平; 张冠杰; 杭程; 王露露; 师韩菲; 柯婷
Original assignee: Shaanxi Traditional Chinese Medicine Hospital
Current assignee: Shaanxi Traditional Chinese Medicine Hospital
Priority date: 2022-11-30
Filing date: 2022-11-30
Publication date: 2023-05-02

Abstract

The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a medicine composition for treating thyroid nodule, which comprises the following components in parts by weight: 1-10 parts of radix bupleuri, 5-20 parts of fructus forsythiae, 1-10 parts of platycodon grandiflorum, 1-10 parts of stiff silkworm, 5-20 parts of citron, 5-20 parts of spatholobus stem, 1-10 parts of radish seed and 5-20 parts of tangerine seed; it has the advantages of soothing liver, regulating qi, resolving phlegm, resolving masses, promoting blood circulation, removing blood stasis, reducing thyroid nodule, etc.

Description

Pharmaceutical composition for treating thyroid nodule

Technical Field

The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a medicine composition for treating thyroid nodule.

Background

Thyroid nodules include benign nodules, toxic nodular goiter, simple nodular goiter. Strange lymphothyroiditis, subacute thyroiditis, and the like. Thyroid nodules are commonly seen as benign swelling and pain. Clinically manifested as a lump in the neck, distension and choking of the neck, a feeling of obstruction in the throat, or with palpitation, vexation, irritability and hyperhidrosis; a few of the patients can feel distending pain in the neck, and the voice is clear and mute. The goiter can be caused by nodular goiter, thyroid adenoma or thyroid heart, and the like, and is manifested by cervical swelling, which can move up and down along with swallowing action, such as obvious increase of thyroid gland, and can cause compression symptoms, such as cough, shortness of breath, hoarseness, dysphagia, and the like; such as intra-nodular hemorrhage, there may be distending pain.

Thyroid nodules can be caused by a variety of causes: (1) proliferative nodular goiter: excessive or too low iodine intake, eating goiter-causing substances, taking goiter-causing drugs or thyroid hormone synthase deficiency, etc. (2) neoplastic nodules: thyroid benign tumor, thyroid papilloma, follicular cell carcinoma, thyroid medullary carcinoma, undifferentiated carcinoma, lymphoid carcinoma, and other thyroid follicular cell and non-follicular cell malignant tumors, and metastatic carcinoma. (3) cyst: nodular goiter, adenomatosis degeneration and cystic fibrosis of old bleeding, cystic fibrosis of thyroid carcinoma, congenital hyoid cysts and cysts caused by fourth gill fissure residues. (4) inflammatory nodules: acute suppurative thyroiditis, subacute suppurative thyroiditis and chronic lymphocytic thyroiditis can all occur in the form of nodules. In rare cases thyroid nodules are caused by tuberculosis or syphilis.

Treatment for thyroid nodules was as follows: (1) a substantial single junction: nuclide scan is a thyroid single shot nodule of hot nodules with less likelihood of cancerous changes. Cold nodules often require surgical treatment. For those with rapid development and hard texture, or those with enlarged cervical lymph nodes or children, the malignant tumor may be large, and the operation should be performed early. (2) multinode goiter: MNG is traditionally thought to have fewer chances to develop cancer than a single shot nodule. Whereas many cases of single-shot nodules were found to be actually multiple nodules by high-resolution ultrasound examination, it is now believed that there is little difference in the incidence of cancer between the two. Therefore, the treatment of MNG is first to exclude malignancy. If sTSH decreases, hyperthyroidism is indicated. If FNA cytologically diagnosed as malignant or suspected malignant, the patient should be treated surgically. (3) futile nodules: in recent years, due to the development of B-ultrasound, CT and MRI, small and inapplicable thyroid nodules can be unexpectedly found when other examinations are performed. This situation is common to the elderly, generally without a history of thyroid disease and without risk factors for thyroid cancer, with nodules less than 1.5cm, and if the nodules are greater than 1.5cm, the nodules can be subjected to FNA under ultrasound guidance and then further processed according to cytological results. (4) radiation nodule: the head and neck is prone to thyroid cancer in the radiation therapist, and is as early as 5 years and as late as 30 years after radiation. For thyroid nodule after head and neck receive radiotherapy, FNA diagnosis should be made.

The treatment method aiming at thyroid nodule basically adopts the treatment means of open surgery, and has the problems of long recovery period of patients, poor comfort of recovery period of patients and the like.

Disclosure of Invention

The invention aims at overcoming the defects and shortcomings of the prior art and providing a pharmaceutical composition for treating thyroid nodule.

The invention relates to a medicine composition for treating thyroid nodule, which comprises the following components in parts by weight: 1-10 parts of radix bupleuri, 5-20 parts of fructus forsythiae, 1-10 parts of platycodon grandiflorum, 1-10 parts of stiff silkworm, 5-20 parts of citron, 5-20 parts of spatholobus stem, 1-10 parts of radish seed and 5-20 parts of tangerine seed.

Further, the medicine for treating thyroid nodule comprises the following components in parts by mass: 5 parts of bupleurum, 10 parts of weeping forsythia, 5 parts of platycodon root, 5 parts of stiff silkworm, 10 parts of citron, 10 parts of spatholobus stem, 5 parts of radish seed and 10 parts of tangerine seed.

Further, the medicine for treating thyroid nodule comprises the following components in parts by mass: 3 parts of bupleurum, 8 parts of weeping forsythiae capsule, 4 parts of platycodon root, 3 parts of stiff silkworm, 8 parts of citron, 8 parts of spatholobus stem, 3 parts of radish seed and 8 parts of tangerine seed.

Further, the medicine for treating thyroid nodule comprises the following components in parts by mass: 6 parts of bupleurum, 14 parts of weeping forsythia, 5 parts of platycodon grandiflorum, 7 parts of stiff silkworm, 16 parts of citron, 12 parts of spatholobus stem and leaf, 8 parts of radish seed and 16 parts of orange core.

Further, the medicine for treating thyroid nodule comprises the following components in parts by mass: 5 parts of bupleurum, 12 parts of fructus forsythiae, 5 parts of platycodon grandiflorum, 9 parts of stiff silkworm, 14 parts of citron, 16 parts of spatholobus stem, 12 parts of radish seed and 14 parts of tangerine seed.

The invention has the beneficial effects that: the medicine composition for treating thyroid nodule has the advantages of soothing liver, regulating qi, resolving phlegm, resolving masses, activating blood circulation to dissipate blood stasis, shrinking thyroid nodule and the like.

Detailed Description

The present invention will be described in detail with reference to specific examples, wherein the exemplary examples and descriptions are provided for the purpose of illustrating the invention only and are not to be construed as limiting the invention.

The medicine for treating thyroid nodule comprises the following components in parts by weight: 1-10 parts of radix bupleuri, 5-20 parts of fructus forsythiae, 1-10 parts of platycodon grandiflorum, 1-10 parts of stiff silkworm, 5-20 parts of citron, 5-20 parts of spatholobus stem, 1-10 parts of radish seed and 5-20 parts of tangerine seed.

The working principle of the invention is as follows:

the invention relates to a medicine for treating thyroid nodule, which comprises the following components in parts by weight: 1-10 parts of radix bupleuri, 5-20 parts of fructus forsythiae, 1-10 parts of platycodon grandiflorum, 1-10 parts of stiff silkworm, 5-20 parts of citron, 5-20 parts of spatholobus stem, 1-10 parts of radish seed and 5-20 parts of tangerine seed.

The optimal scheme of the invention is as follows: 5 parts of bupleurum, 10 parts of weeping forsythia, 5 parts of platycodon grandiflorum, 5 parts of stiff silkworm, 10 parts of citron, 10 parts of spatholobus stem, 5 parts of radish seed and 10 parts of orange core; the composition comprises the following components in percentage by weight: fructus forsythiae: radix Platycodi: stiff silkworm: and citron fruit: caulis Spatholobi: radish seed: orange core = 1:2:1:1:2:2:1:2.

the preparation method of the medicine composition for treating thyroid nodule comprises the following steps:

step one: 5 parts of bupleurum, 10 parts of weeping forsythia, 5 parts of platycodon grandiflorum, 5 parts of stiff silkworm, 10 parts of citron, 10 parts of spatholobus stem, 5 parts of radish seed, 10 parts of orange core and a plurality of water; soaking in decoction pot for 10-30min until water reaches 2-4cm to form initial mixed medicine; wherein: the decoction pot is a marmite; the water is purified water or distilled water. The above components are crushed and crushed in advance.

Step two: boiling the initial mixed medicine soaked in the first step by using strong fire to realize decoction;

step three: then decocting with slow fire for 20-30min to obtain medicinal liquid;

step four: and D, respectively pouring the liquid medicine obtained in the step three into medicine bags according to the dosage after filtering the medicine residues, and sealing and pressing the mouth ends of the medicine bags.

The functional roles of the components in the invention are as follows:

(1) Bupleurum root: traditional Chinese medicines are derived from dry roots of Bupleurum scorzonerifolium of Umbelliferae or Bupleurum scorzonerifolium, and are known as Bupleurum chinense and Bupleurum scorzonerifolium respectively according to different properties.

Bupleuri radix is bitter, pungent and slightly cold in nature and enters liver meridian and gallbladder meridian. The efficacy is as follows: relieving exterior syndrome and fever, soothing liver and relieving depression, and lifting yang qi. Can be used for treating common cold with fever, cold and heat, chest pain, menoxenia, uterine prolapse, and rectocele. Bupleuri radix Xin Sangu, which has effects of dispelling pathogenic factors, relieving exterior syndrome and relieving fever, and dispelling pathogenic factors of the exterior and interior of the shaoyang half, can be used for treating exterior syndrome due to exogenous fever, no matter the symptoms of wind-cold and wind-heat. Bupleuri radix can also be used for treating depression, menstrual disorder, dysmenorrhea, etc. Note item: bupleuri radix is carefully used for patients with hyperactivity of yang due to yin deficiency, hyperactivity of liver wind and hyperactivity of fire due to yin deficiency.

(2) Fructus forsythiae: clearing heat and detoxicating, eliminating carbuncle and resolving hard mass, and dispelling wind-heat. Fructus forsythiae has the main effects of clearing heat and detoxicating, resolving carbuncles and resolving masses, and dispelling wind and heat. The effects are mainly used for carbuncle sore, toxic swelling, scrofula and phlegm nodule.

Fructus forsythiae is bitter and cold, mainly enters heart meridian, can clear heart fire, resolve sore toxin, dispel qi and blood coagulation, has the actions of resolving carbuncles and resolving masses, and is called as a self-contained sore-family holy medicine. For sores and ulcers, it is often combined with jin Yin Hua, pu Ying and Ye Ju Hua, etc., as the drugs for removing toxic substances and relieving swelling; is used for treating exogenous wind-heat, at the beginning of warm disease, bitter in fructus forsythiae and capable of purging pathogenic fire and cold and clearing heat; entering heart and lung meridians, it is often indicated for clearing heart fire, dispelling wind-heat from upper-jiao, often combined with jin Yin Hua, bo He and niu bang Zi, for example, it is often combined with Xuan Shen, dan Pi and jin Yin Hua to clear heat and detoxify, remove heat and transfer qi, such as Qing Ying Tang; for high fever and unconsciousness due to heat entering pericardium, it is often combined with heart-clearing and fire-purging herbs such as Lian Qiao Xin, mai Dong and Lian Zi Xin, for instance, qing Gong Tang. Lian Qiao can also be used for treating stranguria due to heat and pain, and is usually combined with Zhu Ye. Mu Tong and Bai Mao Gen are combined with diuretics and Tong Ling, and have the actions of clearing heart fire and inducing urination.

(3) Radix Platycodi: the root of the grass is firm and straight, so it is called balloon flower. Is dry root of radix Platycodi of Campanulaceae, bitter and pungent in taste, and slightly warm in nature. Enter the lung meridian. Has effects of eliminating phlegm, relieving cough, dispersing lung qi, and expelling pus. The source of this herb is Shen nong Ben Cao Jing, which is classified into antitussive and expectorant herbs.

Radix Platycodi has effects of dispersing lung qi, clearing heat from throat, eliminating phlegm, relieving cough, and expelling pus, and can be used for treating cough, excessive phlegm, laryngopharynx swelling and pain, lung abscess, chest distress, hoarseness, bacillary dysentery, abdominal pain, pyocutaneous disease without ulcer, chest and hypochondrium pain, and urination disorder. Radix Platycodi also has effects of lowering blood sugar, inhibiting gastric secretion, resisting ulcer, relieving inflammation, dilating blood vessel, tranquilizing, relieving pain, and relieving fever.

(4) Stiff silkworm: wind-extinguishing, spasm-stopping, wind-dispelling, pain-relieving, phlegm-resolving and mass-resolving. The Bombyx Batryticatus is a Chinese medicinal material derived from Bombyx mori of Bombyceae, and five-instar larva of Bombyx mori, and is a lethal dry body after infection or artificial inoculation of Beauveria bassiana. The stiff silkworm is stir-baked with bran in clinic, and is salty in nature, pungent and flat in nature, and enters liver meridian, lung meridian and stomach meridian.

The stiff silkworm has the effects and actions of extinguishing wind and relieving spasm, dispelling wind and relieving pain, resolving phlegm and resolving masses, and is clinically used for treating liver wind and phlegm, convulsion and convulsion, infantile acute convulsion, tetanus, facial distortion due to apoplexy, wind-heat headache, conjunctival congestion and pharyngalgia, rubella and pruritus, mumps and the like. The Bombyx Batryticatus has tranquilizing, anticonvulsant, anticoagulant, and antithrombotic effects. The main components of the stiff silkworm contain fat, protein, amino acid, trace elements and the like, and the stiff silkworm is recorded in the ' materia medica schema of materia medica ', and is used for treating head wind, women's galactostasis, metrorrhagia and the like, so the stiff silkworm has wide clinical application.

(5) And citron fruit: "induce diaphragmatic action to arrest vomiting, regulate the middle warmer to resolve phlegm, sooth liver and regulate qi. The other name is citric acid or citric acid fruit, which belongs to shrubs or small trees with irregular branches. The new-born shoots, buds and buds are dark purple-red. Single leaf, thin single-body compound leaf, oval or oval leaf edge with shallow and blunt split teeth. The citron has the effects of benefiting diaphragm, preventing vomiting, harmonizing middle energizer, reducing phlegm, soothing liver and regulating qi. The medicine can be used for treating symptoms such as abdominal distention, dyspepsia, emesis, belch, excessive phlegm, cough, etc.

The citron contains abundant vitamin C, can improve the immunity of the body, and simultaneously changes and increases the blood supply of cardiac muscle, thereby having good conditioning on the blood supply function of the heart. In addition, common cold can be effectively prevented by frequent eating of citron, cholesterol in the body can be reduced, and thrombus lesions caused by plaque in the blood vessel wall can be prevented. In addition, it contains abundant hesperidin, and can inhibit gastric acid and resist cancer. Furthermore, it is possible to provide a device for the treatment of a disease. The citron also has the effects of regulating qi, soothing liver and the like, so that the citron has good conditioning effect on spleen and stomach dyspepsia and liver depression and qi stagnation.

(6) Caulis Spatholobi is prepared from: perennial vines, wild in mountain woods and mountain shrubs, are mainly produced in Guangdong, guangxi, yunnan and other areas. The dried rattan stem is used as a traditional Chinese medicine for activating blood and replenishing blood, and the medicinal history is long. Caulis Spatholobi is stem of Leguminosae such as Spatholobus stem, mucuna birdwoodiana, or Mucuna birdwoodiana. Bitter and sweet in taste and warm in nature; heart and spleen channels; efficacy: promoting blood circulation, replenishing blood, relaxing tendons, activating collaterals, regulating menstruation and relieving pain. The function is as follows: it is indicated for soreness, numbness, paralysis, arthralgia due to wind-dampness, sallow complexion due to blood deficiency and irregular menstruation.

(7) Radish seed: sex flavor meridian tropism: pungent, sweet and flat. Enter spleen, stomach and lung meridians. The radish seed has the effects of mainly promoting digestion, removing distention, reducing qi and resolving phlegm, and has the effects of treating abdominal distension caused by food stagnation and food stagnation, constipation and excessive phlegm in the lung.

(8) Orange core: is the seed of orange, has bitter and warm taste, enters liver meridian, and has the effects of regulating qi, resolving hard mass and relieving pain. Has the effects of regulating qi-flowing, resolving hard mass and relieving pain, and can be used for treating hernia pain, swelling and pain of testis, acute mastitis, and mammary obstruction.

The clinical test of the invention is as follows:

(1) Group A is 20 people with 20-30 years old patients; group B with patients 20 aged 31-45 years; group C was treated with 20 persons from 46 to 60 years old.

(2) The time period is 30 days as a treatment course; taking the medicine: taken three times a day on an empty stomach.

(3) Data comparison:

the prescription composition is aimed at obviously reducing thyroid nodule in different age groups.

The medicine composition for treating thyroid nodule has the advantages of soothing liver, regulating qi, resolving phlegm, resolving masses, activating blood circulation to dissipate blood stasis, shrinking thyroid nodule and the like.

The foregoing description is only of the preferred embodiments of the invention, and all changes and modifications that come within the meaning and range of equivalency of the features and concepts described herein are therefore intended to be embraced therein.

Claims

1. The medicine composition for treating thyroid nodule is characterized by comprising the following components in parts by weight: 1-10 parts of radix bupleuri, 5-20 parts of fructus forsythiae, 1-10 parts of platycodon grandiflorum, 1-10 parts of stiff silkworm, 5-20 parts of citron, 5-20 parts of spatholobus stem, 1-10 parts of radish seed and 5-20 parts of tangerine seed.

2. A pharmaceutical composition for treating thyroid nodules according to claim 1, wherein: the components in parts by weight are as follows: 5 parts of bupleurum, 10 parts of weeping forsythia, 5 parts of platycodon root, 5 parts of stiff silkworm, 10 parts of citron, 10 parts of spatholobus stem, 5 parts of radish seed and 10 parts of tangerine seed.

3. A pharmaceutical composition for treating thyroid nodules according to claim 1, wherein: the components in parts by weight are as follows: 3 parts of bupleurum, 8 parts of weeping forsythiae capsule, 4 parts of platycodon root, 3 parts of stiff silkworm, 8 parts of citron, 8 parts of spatholobus stem, 3 parts of radish seed and 8 parts of tangerine seed.

4. A pharmaceutical composition for treating thyroid nodules according to claim 1, wherein: the components in parts by weight are as follows: 6 parts of bupleurum, 14 parts of weeping forsythia, 5 parts of platycodon grandiflorum, 7 parts of stiff silkworm, 16 parts of citron, 12 parts of spatholobus stem and leaf, 8 parts of radish seed and 16 parts of orange core.

5. A pharmaceutical composition for treating thyroid nodules according to claim 1, wherein: the components in parts by weight are as follows: 5 parts of bupleurum, 12 parts of fructus forsythiae, 5 parts of platycodon grandiflorum, 9 parts of stiff silkworm, 14 parts of citron, 16 parts of spatholobus stem, 12 parts of radish seed and 14 parts of tangerine seed.