CN116035570A - Stretchable physiological monitor attached to earlobe and method thereof - Google Patents

Stretchable physiological monitor attached to earlobe and method thereof Download PDF

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Publication number
CN116035570A
CN116035570A CN202210380107.8A CN202210380107A CN116035570A CN 116035570 A CN116035570 A CN 116035570A CN 202210380107 A CN202210380107 A CN 202210380107A CN 116035570 A CN116035570 A CN 116035570A
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China
Prior art keywords
stretchable
physiological monitor
earlobe
light
flexible
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CN202210380107.8A
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Chinese (zh)
Inventor
吴铭强
陈华民
卢燕
赵江
甘剑达
文龙
孙朝阳
杨威
王军
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Minjiang University
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Minjiang University
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Priority to CN202210380107.8A priority Critical patent/CN116035570A/en
Publication of CN116035570A publication Critical patent/CN116035570A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552Details of sensors specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1072Measuring physical dimensions, e.g. size of the entire body or parts thereof measuring distances on the body, e.g. measuring length, height or thickness
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1075Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1079Measuring physical dimensions, e.g. size of the entire body or parts thereof using optical or photographic means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6814Head
    • A61B5/6815Ear
    • A61B5/6816Ear lobe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0242Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0242Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0252Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/164Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention relates to a stretchable physiological monitor attached to an earlobe, which comprises a light-emitting unit, a detector unit, a temperature sensor, a humidity sensor, a flexible circuit, a flexible functional shell, a power supply module, a control module and a signal processing module, wherein the light-emitting unit is connected with the detector unit; the light-emitting unit, the detector unit, the temperature sensor, the humidity sensor, the power module, the control module and the signal processing module are all arranged on the flexible circuit; the flexible circuit is encapsulated inside the flexible functional housing. The invention can rapidly and accurately measure important physiological information of the measured personnel, such as blood oxygen saturation, blood sugar concentration and the like, the extensible attaching design can enable the monitor to be in close contact with the skin, the accuracy and the precision are improved, the double-sided temperature and humidity design and the detector distribution can be optimally laid out, the signal interference is reduced, and the invention has wide market prospect in the fields of flexible electronics and wearable medical treatment.

Description

Stretchable physiological monitor attached to earlobe and method thereof
Technical Field
The invention relates to the field of physiological monitoring, in particular to a stretchable physiological monitor attached to an earlobe and a method thereof.
Background
In China, the death caused by cardiovascular diseases accounts for about 40% of the total death composition ratio, and the health of people is greatly threatened. Cardiovascular disease is characterized by sudden and dangerous, but studies indicate that 72% of patients have significant discomfort before sudden cardiac arrest occurs, with 70% of patients having symptoms lasting more than 15 minutes. Therefore, the real-time electrocardiographic monitoring of the patient and the timely discovery of the electrocardiographic abnormal change are of great significance for preventing and treating cardiovascular diseases. The traditional medical intelligent physiological monitor has the defect of inconvenient use.
Disclosure of Invention
Therefore, the invention aims to provide a stretchable physiological monitor attached to an earlobe and a method thereof, which can be carried conveniently and realize real-time physiological monitoring.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a stretchable physiological monitor attached to an earlobe comprises a light-emitting unit, a detector unit, a temperature sensor, a humidity sensor, a flexible circuit, a flexible functional shell, a power supply module, a control module and a signal processing module; the light-emitting unit, the detector unit, the temperature sensor, the humidity sensor, the power module, the control module and the signal processing module are all arranged on the flexible circuit; the flexible circuit is encapsulated inside the flexible functional housing.
Further, the light emitting unit includes 5 lasers of different wavelengths, including green light for measuring the thickness of the earlobe, red light for measuring the blood oxygen concentration, infrared light for measuring the blood glucose concentration, and two near infrared light.
Further, the detector unit includes two InGaAs detectors, one for receiving reflected signals of red light and near infrared light and one for receiving transmitted signals of green light, near infrared light and infrared light.
Further, the flexible functional shell comprises a flexible shading layer, a stretchable substrate and a flexible package which are sequentially arranged; two magnets are symmetrically arranged between the stretchable substrates; the two magnets are adsorbed together after the stretchable physiological monitor is bent.
Further, the temperature sensor comprises two units which are respectively arranged at two sides of the stretchable physiological monitor after being bent.
Further, the humidity sensor comprises two units which are respectively arranged at two sides of the stretchable physiological monitor after being bent.
Further, the control module is respectively connected with the control light-emitting unit, the detection unit, the temperature sensor, the humidity sensor, the power module and the signal processing module, and obtains and controls the data of each unit.
Further, the stretchable substrate material and the flexible packaging material adopt one or more of polydimethylsiloxane, aliphatic or aromatic random copolymerized polyester, polyacrylate, polymethyl silicone resin, amino silicone resin or fluorine silicone resin.
Furthermore, the 5 lasers of the light-emitting unit are all positioned on the front surface of the earlobe and are divided into three groups of red light, near infrared light, infrared light and green light, and the 5 wavelengths are not mutually intersected.
A control method of a stretchable physiological monitor fitting an earlobe, comprising the steps of:
step S1, properly stretching the stretchable physiological monitor, and respectively placing two magnets on the opposite front and back sides of the earlobe to loosen the two magnets, so as to fix the stretchable physiological monitor on the earlobe;
s2, converting the electric signals of the temperature sensor and the humidity sensor into temperature and humidity information by the signal processing module, analyzing the influence of temperature and humidity fluctuation on signal processing, converting the electric signals of the front detector into blood oxygen saturation signals, converting the electric signals of the back detector into earlobe thickness signals and partial blood sugar information, and calculating the blood sugar concentration value of the measured person according to the earlobe thickness, the blood oxygen saturation and the partial blood sugar information of the measured person;
and step S3, the acquired detection data are sent to the mobile terminal.
Compared with the prior art, the invention has the following beneficial effects:
the invention can rapidly and accurately measure important physiological information of the measured personnel, such as blood oxygen saturation, blood sugar concentration and the like, the extensible attaching design can enable the monitor to be in close contact with the skin, the accuracy and the precision are improved, the double-sided temperature and humidity design and the detector distribution can be optimally laid out, the signal interference is reduced, and the invention has wide market prospect in the fields of flexible electronics and wearable medical treatment.
Drawings
FIG. 1 is a schematic diagram of an apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic view of a folded device according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a detection method according to an embodiment of the invention;
the device comprises a 1-luminous unit, a 2-detector unit, a 3-temperature sensor, a 4-humidity sensor, a 5-flexible circuit, a 6-flexible functional housing, a 7-power module, an 8-control module and a 9-signal processing module.
Detailed Description
The invention will be further described with reference to the accompanying drawings and examples.
Referring to fig. 1, the present invention provides a stretchable physiological monitor fitting an earlobe, comprising: the device comprises a light emitting unit, a detector unit, a temperature sensor, a humidity sensor, a flexible circuit, a flexible functional shell, a power module, a control module and a signal processing module.
In this embodiment, the light emitting unit includes 5 lasers with different wavelengths, which are respectively green light, red light, infrared light, and two near infrared lights, and the 5 wavelengths do not intersect with each other; green light is used to measure earlobe thickness, red light and one near infrared light are used to measure blood oxygen concentration, and the other near infrared light and infrared light are used to measure blood glucose concentration.
In this embodiment, the detector unit includes two InGaAs detectors, and 2 detectors are respectively located on the front and back sides of the earlobe, where the front detector is configured to receive reflected signals of red light and near infrared light, and the response band includes at least red light and near infrared light; the detector on the back side is used for receiving transmission signals of green light, near infrared light and infrared light. The reflected signals received by the front detector contain blood oxygen information, and the blood oxygen signals are converted into electric signals and fed back to the signal processing module. The transmission signal received by the detector on the back contains the thickness of the earlobe (green light signal) and partial blood sugar information (near infrared light and infrared light), and the thickness and blood sugar signals are converted into electric signals and fed back to the signal processing module.
In this embodiment, 2 sensors of the temperature sensor are respectively located on the front and back of the earlobe, so that temperatures near the light emitting unit and the detector unit can be monitored, and temperature information is converted into voltage signals and fed back to the signal processing module.
In this embodiment, 2 sensors of the humidity sensor are respectively located on the front and back of the earlobe, and are used for monitoring the humidity near the light emitting unit and the detector unit, converting the humidity information into a voltage signal, and feeding the voltage signal back to the signal processing module.
In this embodiment, the flexible circuit is a polymer/electrode/polymer sandwich structure, and the polymer provides protection and support for the electrode and may be one of polydimethylsiloxane, aliphatic or aromatic random copolymer polyester, polyacrylate, polymethyl silicone, amino silicone or fluorosilicone; the shape of the electrode is one of a first-order or second-order self-similar snake shape, a saddle shape, a semicircle shape and an ellipse shape.
In this embodiment, the flexible functional housing of the stretchable physiological monitor may be stretched and bent, and the stretchable substrate material and the flexible packaging material may be one or more of polydimethylsiloxane, aliphatic or aromatic random copolymer polyester, polyacrylate, polymethyl silicone, amino silicone or fluorosilicone; the flexible shading layer is black, so that the influence of ambient light on the performance of the monitor is prevented; the two magnets are positioned between the stretchable substrate and the light shielding layer, and the two magnets are arranged to be attracted together when being opposite to each other.
In this embodiment, the signal processing module is configured to process the measured electrical signal to obtain a blood oxygen saturation level, a blood glucose concentration, and a temperature and humidity value, and transmit the signal to other terminals.
The foregoing description is only of the preferred embodiments of the invention, and all changes and modifications that come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims (10)

1. The stretchable physiological monitor is characterized by comprising a light-emitting unit, a detector unit, a temperature sensor, a humidity sensor, a flexible circuit, a flexible functional shell, a power module, a control module and a signal processing module; the light-emitting unit, the detector unit, the temperature sensor, the humidity sensor, the power module, the control module and the signal processing module are all arranged on the flexible circuit; the flexible circuit is encapsulated inside the flexible functional housing.
2. The stretchable physiological monitor according to claim 1, wherein said light emitting unit comprises 5 lasers of different wavelengths, including green light for measuring the thickness of the earlobe, red light for measuring blood oxygen concentration, infrared light for measuring blood glucose concentration, and two near infrared light for measuring blood glucose concentration.
3. The conformable earlobe stretchable physiological monitor of claim 1 wherein the detector unit comprises two InGaAs detectors, one for receiving red and near infrared reflected signals and one for receiving green, near infrared and infrared transmitted signals.
4. The stretchable physiological monitor fitting an earlobe of claim 1, wherein the flexible functional housing comprises a flexible light shielding layer, a stretchable substrate and a flexible package arranged in sequence; two magnets are symmetrically arranged between the stretchable substrates; the two magnets are adsorbed together after the stretchable physiological monitor is bent.
5. The stretchable physiological monitor according to claim 4, wherein the temperature sensor comprises two units respectively disposed on two sides of the stretchable physiological monitor after being bent.
6. The stretchable physiological monitor according to claim 4, wherein the humidity sensor comprises two units respectively disposed on two sides of the stretchable physiological monitor after being bent.
7. The stretchable physiological monitor according to claim 1, wherein the control module is connected to the control lighting unit, the detection unit, the temperature sensor, the humidity sensor, the power module and the signal processing module, respectively, and obtains and controls data of each unit.
8. The stretchable physiological monitor according to claim 4, wherein the stretchable backing material and the flexible packaging material are one or more of polydimethylsiloxane, aliphatic or aromatic random copolymer polyester, polyacrylate, polymethyl silicone, amino silicone, and fluorosilicone.
9. The stretchable physiological monitor according to claim 1, wherein the 5 lasers of the light emitting unit are all located on the front surface of the earlobe, and are divided into three groups of red light, near infrared light, infrared light and green light, and the 5 wavelengths do not intersect each other.
10. A control method of a stretchable physiological monitor attached to an earlobe, comprising the steps of:
step S1, properly stretching the stretchable physiological monitor, and respectively placing two magnets on the opposite front and back sides of the earlobe to loosen the two magnets, so as to fix the stretchable physiological monitor on the earlobe;
s2, converting the electric signals of the temperature sensor and the humidity sensor into temperature and humidity information by the signal processing module, analyzing the influence of temperature and humidity fluctuation on signal processing, converting the electric signals of the front detector into blood oxygen saturation signals, converting the electric signals of the back detector into earlobe thickness signals and partial blood sugar information, and calculating the blood sugar concentration value of the measured person according to the earlobe thickness, the blood oxygen saturation and the partial blood sugar information of the measured person;
and step S3, the acquired detection data are sent to the mobile terminal.
CN202210380107.8A 2022-04-12 2022-04-12 Stretchable physiological monitor attached to earlobe and method thereof Pending CN116035570A (en)

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Application Number Priority Date Filing Date Title
CN202210380107.8A CN116035570A (en) 2022-04-12 2022-04-12 Stretchable physiological monitor attached to earlobe and method thereof

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09215679A (en) * 1996-02-09 1997-08-19 Matsushita Electric Works Ltd Concentration measuring apparatus for humor component
US5974337A (en) * 1995-05-23 1999-10-26 Kaffka; Karoly Method and apparatus for rapid non-invasive determination of blood composition parameters
CN1600271A (en) * 2003-09-24 2005-03-30 株式会社日立制作所 Optical measurement apparatus and blood sugar level measuring apparatus using the same
CN205054226U (en) * 2015-10-13 2016-03-02 黄世通 Blood glucose monitoring analytical equipment
CN107374645A (en) * 2016-05-16 2017-11-24 泰安市康宇医疗器械有限公司 A kind of non-invasive blood sugar instrument
US20180256100A1 (en) * 2017-03-13 2018-09-13 VivaLnk, Inc. Multi-purpose wearable patch for measurement and treatment
CN109394235A (en) * 2018-11-27 2019-03-01 浙江清华柔性电子技术研究院 Flexible blood oxygen transducer and preparation method thereof
CN210044008U (en) * 2019-02-22 2020-02-11 孙雁 Blood sugar detector for children
WO2020130571A1 (en) * 2018-12-19 2020-06-25 전자부품연구원 Non-invasive blood testing device and method
CN111789600A (en) * 2020-07-13 2020-10-20 闽江学院 Structure of ultra-thin and ultra-sensitive blood oxygen monitor
CN217987573U (en) * 2022-04-12 2022-12-09 闽江学院 Stretchable physiological monitor attached to earlobe

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5974337A (en) * 1995-05-23 1999-10-26 Kaffka; Karoly Method and apparatus for rapid non-invasive determination of blood composition parameters
JPH09215679A (en) * 1996-02-09 1997-08-19 Matsushita Electric Works Ltd Concentration measuring apparatus for humor component
CN1600271A (en) * 2003-09-24 2005-03-30 株式会社日立制作所 Optical measurement apparatus and blood sugar level measuring apparatus using the same
CN205054226U (en) * 2015-10-13 2016-03-02 黄世通 Blood glucose monitoring analytical equipment
CN107374645A (en) * 2016-05-16 2017-11-24 泰安市康宇医疗器械有限公司 A kind of non-invasive blood sugar instrument
US20180256100A1 (en) * 2017-03-13 2018-09-13 VivaLnk, Inc. Multi-purpose wearable patch for measurement and treatment
CN109394235A (en) * 2018-11-27 2019-03-01 浙江清华柔性电子技术研究院 Flexible blood oxygen transducer and preparation method thereof
WO2020130571A1 (en) * 2018-12-19 2020-06-25 전자부품연구원 Non-invasive blood testing device and method
CN210044008U (en) * 2019-02-22 2020-02-11 孙雁 Blood sugar detector for children
CN111789600A (en) * 2020-07-13 2020-10-20 闽江学院 Structure of ultra-thin and ultra-sensitive blood oxygen monitor
CN217987573U (en) * 2022-04-12 2022-12-09 闽江学院 Stretchable physiological monitor attached to earlobe

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