CN116035025A - Efficient insecticidal composition and preparation method thereof - Google Patents
Efficient insecticidal composition and preparation method thereof Download PDFInfo
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- CN116035025A CN116035025A CN202310138189.XA CN202310138189A CN116035025A CN 116035025 A CN116035025 A CN 116035025A CN 202310138189 A CN202310138189 A CN 202310138189A CN 116035025 A CN116035025 A CN 116035025A
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- insecticidal composition
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- insecticidal
- polyoxyethylene ether
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- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title description 6
- 239000004480 active ingredient Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 30
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 30
- 239000008267 milk Substances 0.000 claims description 15
- 235000013336 milk Nutrition 0.000 claims description 15
- 210000004080 milk Anatomy 0.000 claims description 15
- 239000003995 emulsifying agent Substances 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 12
- DDVNRFNDOPPVQJ-HQJQHLMTSA-N transfluthrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=CC(F)=C1F DDVNRFNDOPPVQJ-HQJQHLMTSA-N 0.000 claims description 12
- 239000006184 cosolvent Substances 0.000 claims description 11
- ZFHGXWPMULPQSE-SZGBIDFHSA-N (Z)-(1S)-cis-tefluthrin Chemical compound FC1=C(F)C(C)=C(F)C(F)=C1COC(=O)[C@@H]1C(C)(C)[C@@H]1\C=C(/Cl)C(F)(F)F ZFHGXWPMULPQSE-SZGBIDFHSA-N 0.000 claims description 10
- 239000005939 Tefluthrin Substances 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000005892 Deltamethrin Substances 0.000 claims description 3
- 229960002483 decamethrin Drugs 0.000 claims description 3
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- ZCVAOQKBXKSDMS-PVAVHDDUSA-N (+)-trans-(S)-allethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)O[C@@H]1C(C)=C(CC=C)C(=O)C1 ZCVAOQKBXKSDMS-PVAVHDDUSA-N 0.000 claims description 2
- KAATUXNTWXVJKI-NSHGMRRFSA-N (1R)-cis-(alphaS)-cypermethrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-NSHGMRRFSA-N 0.000 claims description 2
- 239000005906 Imidacloprid Substances 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- ISRUGXGCCGIOQO-UHFFFAOYSA-N Rhoden Chemical compound CNC(=O)OC1=CC=CC=C1OC(C)C ISRUGXGCCGIOQO-UHFFFAOYSA-N 0.000 claims description 2
- 229960001901 bioallethrin Drugs 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 229940056881 imidacloprid Drugs 0.000 claims description 2
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 claims description 2
- 229960000490 permethrin Drugs 0.000 claims description 2
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 238000005507 spraying Methods 0.000 abstract description 10
- 241000256054 Culex <genus> Species 0.000 abstract description 8
- 239000003814 drug Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 5
- 241000257226 Muscidae Species 0.000 abstract description 4
- 241001136824 Pyrgotidae Species 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 35
- 241000238631 Hexapoda Species 0.000 description 27
- 238000000354 decomposition reaction Methods 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 10
- 229940082500 cetostearyl alcohol Drugs 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 8
- 238000004088 simulation Methods 0.000 description 8
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 8
- 238000003197 gene knockdown Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000257159 Musca domestica Species 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 4
- 150000002191 fatty alcohols Chemical class 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 235000009161 Espostoa lanata Nutrition 0.000 description 3
- 240000001624 Espostoa lanata Species 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000000575 pesticide Substances 0.000 description 3
- 239000002728 pyrethroid Substances 0.000 description 3
- 241000238876 Acari Species 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- 241000935974 Paralichthys dentatus Species 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000000384 rearing effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241001674044 Blattodea Species 0.000 description 1
- 241000144210 Culex pipiens pallens Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000257229 Musca <genus> Species 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 241000258242 Siphonaptera Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000032669 eclosion Effects 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005338 heat storage Methods 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/22—O-Aryl or S-Aryl esters thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a high-efficiency insecticidal composition, which comprises the following raw materials in percentage by mass: 1-30% of insecticidal active ingredient, 1-40% of auxiliary agent and the balance of deionized water. The efficient insecticidal composition provided by the invention has an excellent control effect, and particularly has an excellent control effect on culex light and houseflies. Can ensure that the knockdown rate and death rate of culex light color and houseflies are 100 percent after 1 hour and 24 hours of medication. Has extremely high use value, can adopt the use modes of spraying and ultra-low volume spraying, and expands the use selection of medicines.
Description
Technical Field
The invention relates to the field of A01N51/00 of patent IPC classification, in particular to a high-efficiency insecticidal composition and a preparation method thereof.
Background
The sanitary insecticide is mainly applied to the field of public health and is a medicament composition for controlling disease medium biology and pests, and the main control targets are mosquitoes, flies, fleas, cockroaches, mites, ticks, ants and the like. Unlike insecticidal compositions for protecting agricultural and forestry crops, hygienic pesticides act directly on the living or working environment of humans, whose protection targets are mainly humans.
At present, the formulation of the sanitary insecticidal composition containing pyrethroid active ingredients is single and concentrated in space spraying emulsifiable concentrates, water emulsions, microemulsions and the like, and the wettable powder, suspending agents, water dispersible granules and the like of the detention spraying type are retained. The prior art (CN 107372578B) provides a sanitary insecticidal suspension emulsion, the active ingredients mainly adopt knockdown pyrethroid and lethal pyrethroid, and an ultra-high molecular weight emulsifier with the molecular weight of 100-2000 ten thousand is adopted for emulsification, so as to improve the system stability. However, in practice, the above-mentioned composition is still an emulsion composition, and although the contact killing effect is good, the retention is not good, and the use of the composition is practically limited to a high molecular weight polymer emulsifier, and the system thereof depends mostly on the stability of the polymer emulsifier itself, and the practical stability has been questionable.
Accordingly, in order to solve the above problems, the present invention provides a sanitary insecticidal composition in a form of a solution having high insecticidal efficacy while maintaining excellent stability.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present invention provides a high-efficiency insecticidal composition, which comprises the following raw materials in percentage by mass: 1-30% of insecticidal active ingredient, 1-40% of auxiliary agent and the balance of deionized water.
As a preferable scheme, the insecticidal active ingredients are at least two of transfluthrin, tefluthrin, beta-cypermethrin, deltamethrin, propoxur, bioallethrin, permethrin, prochlorethrin, prochlorethamate, deltamethrin and imidacloprid.
As a preferred embodiment, the insecticidal active ingredients are transfluthrin and tefluthrin; the mass ratio of the transfluthrin to the tefluthrin is 5-15:1-2.
As a preferable scheme, the mass ratio of the transfluthrin to the tefluthrin is 8-10:1.
As a preferred scheme, the mass ratio of the transfluthrin to the tefluthrin is 9:1.
As a preferable scheme, the auxiliary agent is a mixture of a surfactant, an emulsifying agent and a cosolvent, wherein the mass ratio of the surfactant to the emulsifying agent to the cosolvent is 5-10: 5-20: 5 to 20.
As a preferable scheme, the mass ratio of the surfactant to the emulsifier to the cosolvent is 6:10:12.
as a preferred scheme, the emulsifier is at least one of agricultural milk 1600, agricultural milk 1601, agricultural milk 1602, agricultural milk 500, agricultural milk 600 and agricultural milk 700.
As a preferred scheme, the emulsifier is at least two of agricultural milk 1602, agricultural milk 500 and agricultural milk 600.
As a preferable scheme, the emulsifier is a mixture of agricultural emulsion 1602 and agricultural emulsion 500, and the mass ratio of the two is 1:1.
As a preferable scheme, the surfactant is at least one of C12-C20 fatty alcohol polyoxyethylene ether.
As a preferable scheme, the surfactant is a mixture of C12-C14 fatty alcohol-polyoxyethylene ether and C15-C20 fatty alcohol-polyoxyethylene ether, and the mass ratio of the C12-C14 fatty alcohol-polyoxyethylene ether to the C15-C20 fatty alcohol-polyoxyethylene ether is 2:1.
As a preferable embodiment, the hydroxyl value of the C12-C20 fatty alcohol polyoxyethylene ether is 80-200 mgKOH/g.
As a preferable embodiment, the hydroxyl value of the C12-C14 fatty alcohol polyoxyethylene ether is 150-180 mgKOH/g.
As a preferable embodiment, the hydroxyl value of the C15-C20 fatty alcohol polyoxyethylene ether is 100-120 mgKOH/g.
As a preferable scheme, the C12-C14 fatty alcohol-polyoxyethylene ether is laurinol polyoxyethylene ether MOA-5; the C15-C20 fatty alcohol-polyoxyethylene ether is cetostearyl alcohol-polyoxyethylene ether O-5.
In the application, the stability of the composition can be effectively improved by adopting the fatty alcohol-polyoxyethylene ether with specific chain length and hydroxyl value, so that the application environment of various pesticide compositions is suitable. The applicant believes that: by using the laureth MOA-5 and cetostearyl alcohol polyoxyethylene ether O-5 disclosed by the application, when the mass ratio of the laureth MOA-5 to the cetostearyl alcohol polyoxyethylene ether O-5 is 2:1, the oxygen, fluorine, nitrogen and the like of lone pair electrons contained in the active ingredients can interact with the fatty alcohol polyoxyethylene ether with specific hydroxyl content, so that the heat stability is improved, meanwhile, the active ingredients with different chain lengths can be wrapped, the compatibility of hydroxyl surfaces with moisture is utilized, a multilayer structure is easy to form, certain interfacial movement resistance is kept under the high-temperature condition, frequent collision of active molecules is avoided, and the condition of diluting emulsion drops is avoided.
As a preferable scheme, the cosolvent is at least one of ethanol, methanol, propylene glycol, glycerol and polyethylene glycol.
As a preferred embodiment, the cosolvent is ethanol.
The second aspect of the present invention provides a method for preparing the above-mentioned efficient insecticidal composition, comprising the steps of: (1) Respectively adding proper deionized water into insecticidal active ingredients to wet or dissolve respectively, and controlling the temperature to be 30-60 ℃ until both the components become transparent liquid; (2) Mixing the liquid obtained in the step (1), adding the rest auxiliary agents, and fully stirring to obtain the final product.
The beneficial effects are that:
1. the efficient insecticidal composition provided by the invention has an excellent control effect, and particularly has an excellent control effect on culex light and houseflies. Can ensure that the knockdown rate and death rate of culex light color and houseflies are 100 percent after 1 hour and 24 hours of medication. Has extremely high use value, can adopt the use modes of spraying and ultra-low volume spraying, and expands the use selection of medicines.
2. The high-efficiency insecticidal composition provided by the invention can effectively improve the stability of the composition by adopting the fatty alcohol-polyoxyethylene ether with specific chain length and hydroxyl value, so that the high-efficiency insecticidal composition is suitable for the use environments of various pesticide compositions. Especially, laurinol polyoxyethylene ether MOA-5 and cetostearyl alcohol polyoxyethylene ether O-5 are adopted, when the mass ratio of the laurinol polyoxyethylene ether MOA-5 to the cetostearyl alcohol polyoxyethylene ether O-5 is 2:1, the oxygen, the fluorine, the nitrogen and the like of lone pair electrons contained in the active ingredients can interact with fatty alcohol polyoxyethylene ether with specific hydroxyl content, so that the thermal stability is improved, meanwhile, the active ingredients with different chain lengths can be wrapped, the compatibility of hydroxyl surfaces and moisture is accelerated, a multilayer structure is easy to form, and therefore certain interfacial movement resistance is kept under the high temperature condition, and the decomposition and turbidity phenomena of the composition are avoided.
Detailed Description
Example 1
Embodiment 1 provides a high-efficiency insecticidal composition in a first aspect, which comprises the following raw materials in percentage by mass: 2.25% of transfluthrin, 0.25% of transfluthrin, 6% of surfactant (laureth MOA-5 and cetostearyl alcohol polyoxyethylene ether O-5 in a mass ratio of 2:1), 10% of emulsifier (agricultural emulsion 1602 and agricultural emulsion 500 in a mass ratio of 1:1), 12% of cosolvent (ethanol) and the balance of deionized water.
In this example, laureth MOA-5 (hydroxyl value 135 mgKOH/g) and cetostearyl alcohol polyoxyethylene ether O-5 (hydroxyl value 115 mgKOH/g) were purchased from Haian cloud chemical Co.
In this example, the composition dosage form is a soluble solution.
The second aspect of the present embodiment provides a method for preparing the above efficient insecticidal composition, comprising the steps of: (1) Respectively taking 50 weight percent of deionized water, respectively adding transfluthrin and tefluthrin for wetting, and controlling the temperature to be 55 ℃ until two parts of solvents become transparent liquid; (2) Mixing the liquid obtained in the step (1), adding the rest of surfactant, cosolvent and emulsifier, and stirring thoroughly.
Comparative example 1
The specific embodiment of this comparative example is the same as example 1, except that: the surfactant is C13 fatty alcohol polyoxyethylene ether E-1308 alone, and the hydroxyl value is 100mgKOH/g.
Comparative example 2
The specific embodiment of this comparative example is the same as example 1, except that: the surfactant is cetostearyl alcohol polyoxyethylene ether O-30 alone, and the hydroxyl value is 36mgKOH/g.
Comparative example 3
The specific embodiment of this comparative example is the same as example 1, except that: the mass ratio of the laurinol polyoxyethylene ether MOA-5 to the cetostearyl alcohol polyoxyethylene ether O-5 is 0.5:1.
Evaluation of Performance
And (3) testing the drug effect: the compositions prepared in the examples were subjected to a pharmacodynamic test.
The specific test method comprises the following steps:
test one: 1. selection of test subjects
The sensitive culex pallidum (Culex pipiens pallens) strain is derived from Beijing military medical institute of microbiology epidemic institute, and is female adult which is not absorbed in blood on 3-4 days of eclosion.
Sensitive housefly (Musca domestca) strain is derived from Beijing city disease prevention and control center, and is adult after emergence at 3-4 days, and male and female halves.
Environmental conditions
Temperature: 26±1 ℃, relative humidity: 60+ -10%.
2. Test instrument
Fluke tube, pipette, colorless transparent cylinder (height 45cm, inner diameter 20 cm), etc.
3. Test method
The cylinder method adopts GB/T13917.1-2009 and CEMPS-SOP-701.03
By sprayingA fog barrel device. 30 culex pallidum or housefly are respectively put into the spraying cylinder from the central round hole of the chassis, and the rubber plug is plugged. After the test insects return to normal activities, the test insects are controlled to be 1.43mL/m 3 The (20. Mu.L) dose was transferred into a small glass tube using a pipette. The spray head is vertically embedded into a central round hole of the chassis of the spray cylinder device. Starting the air compressor, and adjusting the pressure to 9.8x10 through a pressure reducing valve 4 Pa, inserting a leather tube below the spray head into the bottom of a small glass tube filled with the to-be-detected spraying agent, and starting an air valve to spray the spraying agent. And (5) timing immediately after the medicine is sprayed, and recording the number of knocked-down insects at regular intervals. After 20min, the knocked down test insects are collected into a clean insect rearing cage, standard rearing is restored, and the test insects are fed with 5% sugar cotton balls for 24h to check the death number. The number of live insects was counted for 20min of the test insects which were not knocked down. The test was repeated 3 times. After each test, the test device was cleaned.
4. Drug effect calculation method
Determination of KT from test data with SPSS 13.0 software 50 Virulence regression equation, and 24h mortality was calculated, with the result remaining two decimal places.
Number of death of test insects
Mortality (%) = -x 100%
The results are shown in Table 1
TABLE 1
And II, testing:
1. environmental conditions
Temperature: 26±1 ℃, relative humidity: 65.+ -. 10%.
2. Test instrument
28M of fluke tube, hanging cage and four-sided glass 3 Is a simulation room (floor area 10M) 2 X 2.8M high), etc.
3. Test method
The simulation site adopts GB/T13917.10-2009 and CEMPS-SOP-710.02
And 5 cages are hung in total at 4 points and the center which are vertically intersected, wherein the distance between the simulation site and the ground is 1.5m, the distance between two adjacent walls is 0.5m, and 20 insects are released in each cage. After the culex pallidum or the housefly returns to normal activities, a tester stands in the center of the simulation site, holds a glass tube filled with the injection according to the volume of 1.5mL/m 3 (42 mL) dose, spray nozzle up to about 45 deg., turn 360 deg. during spraying. After the application, the test personnel immediately leave the site, and the door and window are closed and timed. Collecting knocked-down test insects into a clean insect raising cage for 1h, recovering standard raising, feeding with 5% sugar cotton balls, checking the dead insects for 24h, and counting the number of the knocked-down test insects as live insects.
4. Drug effect calculation method
And calculating the 1h knockdown rate according to the test result, and calculating the 24h death rate, wherein the result is reserved in two decimal places.
Reciprocal of impact
Knock down rate (%) = -x 100%
Total number of test insects
Number of death of test insects
Total rate of death of test insects (%) = -x 100%
The results are shown in tables 2 and 3
TABLE 2
| Insect test | 1h knockdown Rate (%) | Mortality rate at 24h (%) | Evaluation |
| Culex light color | 100 | 100 | Class A |
| Housefly | 100 | 100 | Class A |
TABLE 3 Table 3
And (3) testing:
dosage of the composition: 20mg preparation/m 3 。
1. Test conditions
Temperature: 26±1 ℃, relative humidity: 65.+ -. 10%.
2. Test instrument
Suction tube, electric ultra-low volume sprayer (model 1035 BP), hanging cage (cylindrical, diameter 15cm, height 25cm, 12 mesh gauze around) and 28m of four-sided glass 3 Simulation house (floor area 10 m) 2 X 2.8m high).
3. Test method
Reference simulation sites GB/T13917.10-2009 and CEMPS-SOP-710.03
And 5 cages are hung in total at 4 points and the center which are vertically intersected, wherein the distance between the simulation site and the ground is 1.5m, the distance between two adjacent walls is 0.5m, and 20 insects are released in each cage. After the test insects return to normal activities, a tester stands at a gate of a simulation site, holds an electric ultralow-volume sprayer, and prepares 20mg of preparation/m of the medicament to be tested 3 Preparation (0.56 g of the drug to be tested was added with water to 42 mL) at 1.5mL/m 3 (42 mL) dose. After the application, the door and window are closed immediately and the time is counted. Collecting knocked-down test insects into a clean insect raising cage for 1h, recovering standard raising, feeding with 5% sugar cotton balls, checking the dead insects for 24h, and counting the number of the knocked-down test insects as live insects.
4. Drug effect calculation method
According to the recorded test data, 1h knockdown rate and 24h mortality rate are calculated, and the calculated result is reserved in 2 decimal places.
Total number of test insects
The results are shown in tables 4, 5 and 6
TABLE 4 Table 4
TABLE 5
TABLE 6
And (4) testing: the compositions provided in examples and comparative examples were evaluated for the content of active ingredient before and after storage in an incubator at 54.+ -. 2 ℃ for 14 days, as measured by 4.11 in HG/T2467.2-2003, and the decomposition rate was calculated, and the smaller the decomposition rate, the better the heat storage stability, the higher the decomposition rate, with the decomposition rate of less than 2.5% being rated, the decomposition rate of 2.5% or more, the decomposition rate of less than 3.5% being rated, the decomposition rate of 3.5% or more, the decomposition rate of less than 5% being rated, the decomposition rate of 5% or more being rated, the decomposition rate of less than 10% being rated, the 5 being rated, and the results are shown in Table 7.
TABLE 7
| Test object | Decomposition rate of transfluthrin | Resolution of tefluthrin |
| Example 1 | Level 1 | Level 1 |
| Comparative example 1 | 3 grade | Grade 4 |
| Comparative example 2 | 3 grade | 3 grade |
| Comparative example 3 | Level 2 | Level 1 |
Claims (10)
1. A high-efficiency insecticidal composition, characterized in that: the raw materials at least comprise the following components in percentage by mass: 1-30% of insecticidal active ingredient, 1-40% of auxiliary agent and the balance of deionized water.
2. The high-efficiency insecticidal composition of claim 1, wherein: the insecticidal active ingredients are at least two of transfluthrin, tefluthrin, beta-cypermethrin, deltamethrin, propoxur, bioallethrin, permethrin, cimetithrin, dexfenpropathrin and imidacloprid.
3. A high efficiency insecticidal composition according to claim 2, wherein: the insecticidal active ingredients are transfluthrin and tefluthrin; the mass ratio of the transfluthrin to the tefluthrin is 5-15:1-2.
4. A high-efficiency insecticidal composition according to any one of claims 2 to 3, wherein: the auxiliary agent is a mixture of a surfactant, an emulsifying agent and a cosolvent, and the mass ratio of the surfactant to the emulsifying agent to the cosolvent is 5-10: 5-20: 5 to 20.
5. The high-efficiency insecticidal composition of claim 4, wherein: the emulsifier is at least one of agricultural milk 1600, agricultural milk 1601, agricultural milk 1602, agricultural milk 500, agricultural milk 600 and agricultural milk 700.
6. A high-efficiency insecticidal composition according to any one of claims 4 to 5, wherein: the surfactant is at least one of C12-C20 fatty alcohol polyoxyethylene ether.
7. The high-efficiency insecticidal composition of claim 6, wherein: the hydroxyl value of the C12-C20 fatty alcohol polyoxyethylene ether is 80-200 mgKOH/g.
8. A high-efficiency insecticidal composition according to any one of claims 4 to 7, wherein: the cosolvent is at least one of ethanol, toluene, methanol, propylene glycol, glycerol and polyethylene glycol.
9. The high-efficiency insecticidal composition of claim 8, wherein: the cosolvent is ethanol.
10. A method of preparing a highly effective insecticidal composition according to any one of claims 1 to 9, characterized in that: the method comprises the following steps: (1) Respectively adding proper deionized water into insecticidal active ingredients to wet or dissolve respectively, and controlling the temperature to be 30-60 ℃ until both the components become transparent liquid; (2) Mixing the liquid obtained in the step (1), adding the rest auxiliary agents, and fully stirring to obtain the final product.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107372578A (en) * | 2017-07-26 | 2017-11-24 | 南通功成精细化工有限公司 | A kind of hygienic biocide suspension emulsion and preparation method thereof |
| CN111034716A (en) * | 2018-10-11 | 2020-04-21 | 江苏功成生物科技有限公司 | Normal-temperature volatile type insecticidal spray composition and application thereof |
| CN112772671A (en) * | 2019-11-11 | 2021-05-11 | 江苏扬农化工股份有限公司 | Dinotefuran-containing compound insecticidal composition and application thereof |
| CN112970788A (en) * | 2021-03-03 | 2021-06-18 | 福建省金鹿日化股份有限公司 | Efficient electric heating mosquito-repellent incense liquid and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107372578A (en) * | 2017-07-26 | 2017-11-24 | 南通功成精细化工有限公司 | A kind of hygienic biocide suspension emulsion and preparation method thereof |
| CN111034716A (en) * | 2018-10-11 | 2020-04-21 | 江苏功成生物科技有限公司 | Normal-temperature volatile type insecticidal spray composition and application thereof |
| CN112772671A (en) * | 2019-11-11 | 2021-05-11 | 江苏扬农化工股份有限公司 | Dinotefuran-containing compound insecticidal composition and application thereof |
| CN112970788A (en) * | 2021-03-03 | 2021-06-18 | 福建省金鹿日化股份有限公司 | Efficient electric heating mosquito-repellent incense liquid and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 王以燕 等: "我国卫生用农药剂型的现状及展望", 中华卫生杀虫药械, vol. 24, no. 6, 20 December 2018 (2018-12-20), pages 517 - 522 * |
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