CN112772671A

CN112772671A - Dinotefuran-containing compound insecticidal composition and application thereof

Info

Publication number: CN112772671A
Application number: CN201911092695.XA
Authority: CN
Inventors: 王燚; 沈阳; 贾炜; 王宝林
Original assignee: Jiangsu Yangnong Chemical Co Ltd
Current assignee: Jiangsu Yangnong Chemical Co Ltd
Priority date: 2019-11-11
Filing date: 2019-11-11
Publication date: 2021-05-11
Anticipated expiration: 2039-11-11
Also published as: CN112772671B

Abstract

The invention discloses a compound insecticidal composition containing dinotefuran and application thereof, wherein the active ingredients comprise dinotefuran and transfluthrin or transfluthrin, and the weight ratio of the dinotefuran to the transfluthrin is 1: 15-15: 1, preferably 1: 4-8: 1; the weight ratio of dinotefuran to transfluthrin is 1: 15-15: 1, preferably 1: 3-8: 1. the insecticide provided by the invention has the advantages that the dinotefuran and the tefluthrin or the transfluthrin are compounded and processed into the water emulsion or the microemulsion, so that the use of organic solvents is reduced, the environment is more friendly, the tefluthrin or the transfluthrin has excellent knockdown performance on public health pests such as mosquitoes and flies, the dinotefuran lethal effect is added, the insecticide has an obvious synergistic effect on preventing and controlling the public health pests, the application amount of the insecticide can be reduced, the cost is saved, and the generation of drug resistance of the pests is delayed.

Description

Dinotefuran-containing compound insecticidal composition and application thereof

Technical Field

The invention relates to an insecticide, and in particular relates to a compound pesticide containing dinotefuran and transfluthrin or transfluthrin.

Background

It is known that most of space sprays for public health pests are pyrethroid type agents, and the insecticide inevitably causes drug resistance of the sanitary pests such as mosquitoes, flies, cockroaches and the like to part of the pyrethroid type agents after long-term use, so that the control effect of the insecticide is greatly reduced. Because the pyrethroid pesticide has excellent knock-down effect on public health pests, if the drug resistance of the pests is considered, the insecticide can be started from the lethal agent; in addition, part of space spraying agents are generally missible oil which contains more organic solvents, so that the environment pollution is easy to be large in the using process, and the spraying agents are not friendly to the drug applicators. Therefore, the development of a non-pyrethroid compound insecticide for preventing and controlling public health pests by space spraying is considered. Dinotefuran belongs to a third-generation nicotine pesticide, has the effects of contact poisoning and stomach poisoning, strong systemic property and long lasting period, and has a wider insecticidal spectrum compared with first and second-generation pesticides. The dinotefuran can be used for preventing and controlling pests on pesticides such as various plant hoppers, whiteflies, aphids, borers and the like, and has high efficiency on sanitary pests such as fleas, cockroaches, termites, mosquitoes and the like. Dinotefuran and transfluthrin or transfluthrin are selected to prepare the environment-friendly emulsion in water or microemulsion through scientific proportioning, so that the control effect on sanitary pests can be improved, the drug resistance of the sanitary pests is relieved, and the environment-friendly effect is realized.

Disclosure of Invention

The invention aims to solve the technical problem of providing a compound insecticidal composition containing dinotefuran, aiming at the defects in the prior art, the insecticidal composition has good insecticidal effect, is compounded with synergism and is not easy to generate drug resistance.

In order to achieve the purpose, the invention adopts the following technical scheme:

a compound insecticidal composition containing dinotefuran is prepared by compounding dinotefuran and transfluthrin/transfluthrin, wherein the weight ratio of dinotefuran to transfluthrin is 1: 15-15: 1, the weight ratio of dinotefuran to transfluthrin is 1: 15-15: 1.

in the above technical scheme, the weight ratio of dinotefuran to transfluthrin is preferably 1: 4-8: 1.

in the above technical scheme, the weight ratio of dinotefuran to transfluthrin is preferably 1: 3-8: 1.

the invention also provides a compound insecticide containing dinotefuran, the formulation is an aqueous emulsion, and the compound insecticide is prepared from the compound insecticide composition containing dinotefuran, a solvent, an emulsifier, an antifreeze, a defoaming agent and water, wherein the ingredients in percentage by weight of the total weight of the aqueous emulsion are as follows: 5 to 20 percent of compound insecticidal composition containing dinotefuran, 10 to 15 percent of solvent, 8 to 15 percent of emulsifier, 5 to 10 percent of antifreeze, 0.1 to 0.5 percent of defoamer and water to make up to 100 percent.

The invention also provides a compound insecticide containing dinotefuran, the dosage form of the compound insecticide is microemulsion, the compound insecticide composition containing dinotefuran is prepared by taking solvent, cosolvent, emulsifier and water as raw materials, and the weight percentages of the components in the total weight of the microemulsion are as follows: 5 to 15 percent of compound insecticidal composition containing dinotefuran, 10 to 15 percent of solvent, 5 to 10 percent of cosolvent, 10 to 20 percent of emulsifier and water to complement to 100 percent.

In the above technical scheme, the emulsifier is selected from: styryl phenol polyoxyethylene ether, phenyl phenol polyoxyethylene ether phosphate, castor oil polyoxyethylene ether phosphate, calcium alkyl benzene sulfonate, alkylphenol polyoxyethylene ether, phenethyl phenol formaldehyde resin polyoxyethylene ether, nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylaryl polyoxypropylene polyoxyethylene ether, alkylaryl polyoxyethylene ether, tween series and span series, or a mixture of two or more of these in any proportion.

In the above technical scheme, the solvent is selected from: any one of dimethyl sulfoxide, N-methyl pyrrolidone, xylene, cyclohexanone, piperonyl butoxide and benzyl alcohol, and a mixture of two or more of the above components in any proportion.

In the above technical scheme, the antifreeze is selected from: any one of ethylene glycol, propylene glycol, urea and sodium chloride, and a mixture of two or more of them in any proportion.

In the above technical solution, the defoaming agent is selected from: any one of organosilicon compounds, C8-10 fatty alcohol compounds or C10-20 saturated fatty acid compounds, and a mixture of two or more of them in any proportion.

In the technical scheme, the cosolvent is selected from: any one of n-butanol, ethanol, glycerol and diethyl carbonate, and a mixture of two or more of the above components in any proportion.

In the technical scheme, the preparation method of the aqueous emulsion comprises the following steps: dissolving dinotefuran and transfluthrin/transfluthrin in a solvent according to the proportion, then adding an emulsifier, fully and uniformly stirring, then turning to a high-speed shearing machine for high-speed shearing, and adding dispersion medium water, an antifreezing agent and an antifoaming agent in the shearing process to finally obtain the compound preparation containing dinotefuran and transfluthrin or transfluthrin with the milky white liquid appearance.

In the technical scheme, the preparation method of the microemulsion comprises the following steps: dissolving dinotefuran and transfluthrin/transfluthrin in a solvent according to the proportion, then adding a cosolvent, an emulsifier and water, and fully and uniformly stirring to obtain a clear and transparent compound preparation containing dinotefuran and transfluthrin or transfluthrin.

The invention also provides application of the dinotefuran-containing compound pesticide in the aspect of preventing and controlling public health pests.

In the above technical scheme, the public health pests refer to mosquitoes, flies and the like

In the technical scheme, the compound pesticide containing dinotefuran is applied in a space spraying mode when preventing and controlling public health pests, and the aqueous emulsion is diluted by 30-200 times with water, and the microemulsion is diluted by 30-200 times with water and then sprayed in the space.

The technical scheme of the invention has the advantages that: the insecticide provided by the invention has the advantages that the dinotefuran and the tefluthrin or the transfluthrin are compounded and processed into the water emulsion or the microemulsion, so that the use of organic solvents is reduced, the environment is more friendly, the tefluthrin or the transfluthrin has excellent knockdown performance on public health pests such as mosquitoes and flies, the dinotefuran lethal effect is added, the insecticide has an obvious synergistic effect on preventing and controlling the public health pests, the application amount of the insecticide can be reduced, the cost is saved, and the generation of drug resistance of the pests is delayed.

Detailed Description

The following detailed description of the embodiments of the present invention is provided, but the present invention is not limited to the following description, and the percentages in the following examples refer to weight percentages unless otherwise specified.

Formulation example 1

Dissolving 1% of dinotefuran and 15% of transfluthrin in 7% of dimethyl sulfoxide and 3% of piperonyl butoxide, then adding 5% of castor oil polyoxyethylene ether and 3% of calcium alkyl benzene sulfonate, stirring fully, shearing by using a high-speed shearing emulsifying machine, adding 8% of glycol and 0.2% of organic silicon defoamer during shearing, and complementing deionized water to 100% to obtain the 16% dinotefuran-transfluthrin aqueous emulsion.

Formulation example 2

Dissolving 1.5% of dinotefuran and 15% of transfluthrin in 10% of N-methylpyrrolidone solvent, then adding 4% of styrylphenol polyoxyethylene ether, 3% of fatty alcohol polyoxyethylene ether and 3% of tween-80, stirring fully, shearing by using a high-speed shearing emulsifying machine, adding 5% of propylene glycol and 0.3% of C8-10 fatty alcohol compound in the shearing process, and complementing deionized water to 100% to obtain the 16.5% dinotefuran-transfluthrin aqueous emulsion.

Formulation example 3

Dissolving 3% of dinotefuran and 15% of transfluthrin in 4% of dimethyl sulfoxide and 6% of cyclohexanone, then adding 4% of nonylphenol polyoxyethylene ether, 2% of phenylphenol polyoxyethylene ether phosphate and 5% of alkylaryl polyoxyethylene ether, fully stirring, shearing by using a high-speed shearing emulsifying machine, adding 10% of propylene glycol and 0.4% of C10-20 saturated fatty acid compound in the shearing process, and complementing deionized water to 100% to obtain the 18% dinotefuran-transfluthrin aqueous emulsion.

Formulation example 4

Dissolving 4% of dinotefuran and 4% of tefluthrin in 10% of N-methyl pyrrolidone and 5% of benzyl alcohol, then adding 5% of castor oil polyoxyethylene ether phosphate, 5% of calcium alkyl benzene sulfonate and 5% of span-60, stirring fully, shearing by using a high-speed shearing emulsifying machine, adding 5% of propylene glycol and 0.5% of organic silicon compounds in the shearing process, and complementing deionized water to 100% to finally obtain 8% of dinotefuran-tefluthrin aqueous emulsion.

Formulation example 5

Dissolving 10% of dinotefuran and 2% of transfluthrin in 10% of dimethyl sulfoxide and 5% of N-methylpyrrolidone, adding 8% of cosolvent N-butyl alcohol, then adding 8% of alkylaryl polyoxypropylene polyoxyethylene ether, 6% of calcium alkylbenzene sulfonate and 6% of Tween-80, supplementing deionized water to 100%, and fully stirring to obtain the 12% dinotefuran-transfluthrin microemulsion.

Formulation example 6

Dissolving 10% of dinotefuran and 1% of transfluthrin in 8% of cyclohexanone and 2% of N-methyl pyrrolidone, adding 9% of cosolvent ethanol, then adding 6% of styrylphenol polyoxyethylene ether, 4% of phenethyl phenol formaldehyde resin polyoxyethylene ether and 2% of fatty alcohol polyoxyethylene ether, complementing deionized water to 100%, and fully stirring to obtain the 11% dinotefuran-transfluthrin microemulsion.

Formulation example 7

Dissolving 7.5% of dinotefuran and 0.5% of transfluthrin in 6% of benzyl alcohol and 4% of xylene, adding 5% of diethyl carbonate as a cosolvent, adding 8% of nonylphenol polyoxyethylene ether, 6% of alkylaryl polyoxyethylene ether and 6% of alkylphenol polyoxyethylene ether, supplementing deionized water to 100%, and fully stirring to obtain the 8% dinotefuran-transfluthrin microemulsion.

Formulation example 8

Dissolving 0.5% of dinotefuran and 7.5% of transfluthrin in 5% of dimethylbenzene and 5% of N-methylpyrrolidone, then adding 4% of span-60, 2% of fatty alcohol polyoxyethylene ether and 2% of calcium alkyl benzene sulfonate, fully stirring, shearing by using a high-speed shearing emulsifying machine, adding 8% of sodium chloride and 0.1% of organic silicon compounds in the shearing process, and complementing deionized water to 100% to finally obtain 8% of dinotefuran-transfluthrin aqueous emulsion.

Formulation example 9

Dissolving 1.5% of dinotefuran and 15% of transfluthrin in 10% of dimethylbenzene and 5% of dimethyl sulfoxide, then adding 5% of phenylphenol polyoxyethylene ether phosphate, 3% of castor oil polyoxyethylene ether and 1% of tween-80, stirring fully, shearing by using a high-speed shearing emulsifying machine, adding 5% of urea and 0.3% of C8-10 fatty alcohol compound in the shearing process, and complementing deionized water to 100% to obtain the 16.5% dinotefuran-transfluthrin aqueous emulsion.

Formulation example 10

Dissolving 2.5% of dinotefuran and 12.5% of transfluthrin in 10% of N-methylpyrrolidone and 5% of benzyl alcohol, then adding 6% of alkylphenol ethoxylate, 4% of fatty alcohol polyoxyethylene ether and 2% of calcium alkylbenzene sulfonate, fully stirring, shearing by using a high-speed shearing emulsifying machine, adding 10% of ethylene glycol and 0.5% of organic silicon compounds in the shearing process, and complementing deionized water to 100% to finally obtain the 15% dinotefuran-transfluthrin aqueous emulsion.

Formulation example 11

Dissolving 6% of dinotefuran and 6% of transfluthrin in 10% of dimethyl sulfoxide and 5% of N-methylpyrrolidone, adding 5% of cosolvent glycerol, then adding 4% of castor oil polyoxyethylene ether, 4% of calcium alkyl benzene sulfonate and 2% of span-60, supplementing deionized water to 100%, and fully stirring to obtain the 12% dinotefuran-transfluthrin microemulsion.

Formulation example 12

Dissolving 12.5% of dinotefuran and 2.5% of transfluthrin in 12% of dimethyl sulfoxide and 3% of N-methylpyrrolidone, adding 10% of cosolvent diethyl carbonate, then adding 6% of alkylphenol polyoxyethylene ether, 4% of styrylphenol polyoxyethylene ether and 5% of nonylphenol polyoxyethylene ether, supplementing deionized water to 100%, and fully stirring to obtain the 15% dinotefuran-transfluthrin microemulsion.

Formulation example 13

Dissolving 10% of dinotefuran and 1% of transfluthrin in 8% of dimethyl sulfoxide and 2% of dimethylbenzene, adding 6% of cosolvent ethanol, then adding 3% of castor oil polyoxyethylene ether phosphate, 4% of phenethyl phenol formaldehyde resin polyoxyethylene ether and 3% of alkylaryl polyoxypropylene polyoxyethylene ether, supplementing deionized water to 100%, and fully stirring to obtain the 11% dinotefuran-transfluthrin microemulsion.

Formulation example 14

Dissolving 6% of dinotefuran and 0.4% of transfluthrin in 6% of N-methyl pyrrolidone and 4% of benzyl alcohol, adding 7% of cosolvent N-butyl alcohol, then adding 7% of castor oil polyoxyethylene ether, 6% of fatty alcohol polyoxyethylene ether and 4% of calcium alkyl benzene sulfonate, supplementing deionized water to 100%, and fully stirring to obtain the 6.4% dinotefuran-transfluthrin microemulsion.

Application example 1: indoor efficacy test for mosquito and fly control

Test targets: culex pipiens pallens, female mosquitoes which do not suck blood 3 to 5 days after eclosion;

housefly, adult, female and male half of 3 rd to 5 th day after eclosion;

the test method comprises the following steps: referring to GB/T13917.10-2009, spatial spraying of a hanging cage test;

and (3) test treatment: formulation examples 1-2, formulation examples 5-6, formulation examples 8-9, formulation examples 11-12 were all diluted to 100 mg/L;

control 1: diluting 5% dinotefuran emulsifiable concentrate to 100 mg/L;

control 2: diluting 5% of tefluthrin emulsifiable concentrate to 100 mg/L;

control 3: 5 percent of transfluthrin emulsifiable concentrate is diluted to 100 mg/L.

And (3) test results:

the indoor pesticide effect result shows that the single-dose missible oil of the control sample 1 is obviously inferior to each preparation example of the invention in knockdown effect on mosquitoes and flies; the 5% of transfluthrin missible oil of the control sample 2 and the 5% of transfluthrin missible oil of the control sample 3 have good knockdown effect on mosquitoes and flies, but have poor lethal effect and low lethality rate; the formulations of the present invention, examples 1-2, 5-6, 8-9, 11-12, not only gave better knockdown, but also higher lethality (see Table 1).

TABLE 1 formulation examples 1-2, 5-6, 8-9, 11-12 efficacy test against mosquitoes and flies

The other preparation examples of the invention are further subjected to the same efficacy test, the knockdown effect is good, and the lethality rate is higher.

Application example 2: emulsifiable concentrate type efficacy test of dinotefuran and tefluthrin or transfluthrin compounded aqueous emulsion, microemulsion and corresponding raw pesticide ratio

housefly, adult, female and male half of 3 rd to 5 th day after eclosion;

and (3) test treatment: the preparation examples 3, 7, 10 and 13 are diluted to 100 mg/L;

control 1: preparation example 3 emulsifiable concentrate with the same raw material ratio is diluted to 100 mg/L;

control 2: in the preparation example 7, missible oil with the same raw medicine proportion is diluted to 100 mg/L;

control 3: in the preparation example 10, missible oil with the same raw medicine proportion is diluted to 100 mg/L;

control 4: preparation example 13 emulsifiable concentrate of the same crude drug ratio was diluted to 100 mg/L.

And (3) test results:

the indoor pesticide effect result shows that in the selected compounding ratio, the pesticide effects of the aqueous emulsion and the microemulsion on mosquitoes and flies are equivalent to those of an emulsifiable concentrate type in knockdown and lethal effects, the aqueous emulsion and the microemulsion use less organic solvents, most of the aqueous emulsion and the microemulsion use water as a matrix, compared with the emulsifiable concentrate, the aqueous emulsion is more environment-friendly, the odor after spraying is small, and meanwhile, the control effect of the invention can reach the pesticide effect of a conventional emulsifiable concentrate type. Specific results are shown in table 2:

table 2 formulation examples 3, 7, 10 and 13 and corresponding cream formulations for testing the efficacy against mosquitoes and flies

Application example 3: pesticide effect test of dinotefuran and tefluthrin or transfluthrin compounded aqueous emulsion, microemulsion and similar products sold in market

housefly, adult, female and male half of 3 rd to 5 th day after eclosion;

and (3) test treatment: the preparation example 2, the preparation example 6, the preparation example 9 and the preparation example 12 are diluted to 100 mg/L;

control 1: diluting 104g/L permethrin S-bioallethrin aqueous emulsion sold in the market to 100 mg/L;

control 2: the commercial microemulsion of 10% permethrin and tetramethrin is diluted to 100 mg/L.

And (3) test results:

the indoor efficacy results show that in the selected embodiment, the efficacy of the aqueous emulsion and the microemulsion on mosquitoes and flies is equivalent to that of the commercial aqueous emulsion and the microemulsion in knockdown and lethal effects. Specific results are shown in table 3:

table 3 formulations examples 2, 6, 9 and 12 and commercial products for testing the efficacy of mosquito and fly

Application example 4: determination of composite pairing culex pipiens pallens co-toxicity coefficient of dinotefuran and transfluthrin or transfluthrin

Test targets: culex pipiens pallens

The test method comprises the following steps: reference to indoor bioassay test criteria for pesticides part one: and (3) a contact killing activity test, namely performing an activity determination test on culex pipiens pallens by adopting a dropping method NY/T1154.1-2006.

The data calculates half lethal concentration value and virulence regression equation according to linear weighted regression method, and calculates cotoxicity coefficient by referring to Sun cloud Pepper method.

TABLE 4 dinotefuran and Tetrafluoroethane pyrethrin cotoxicity coefficient determination (against Culex pipiens pallens)

As shown in Table 4, the compounding ratio of dinotefuran to transfluthrin is 1: 15-15: 1, the common toxicity coefficient for culex pipiens pallens is more than 100, and particularly, when the compounding ratio is 1: 4-8: when 1, the co-toxicity coefficient exceeds 120, and the synergistic effect is obvious.

TABLE 5 dinotefuran and transfluthrin cotoxicity coefficient determination (against Culex pallens)

As shown in table 5, the compounding ratio of dinotefuran to transfluthrin was 1: 15-15: 1, the common toxicity coefficient for culex pipiens pallens is more than 100, and particularly, when the compounding ratio is 1: 3-8: when 1, the co-toxicity coefficient exceeds 120, and the synergistic effect is obvious.

The above examples are only for illustrating the technical concept and features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.

Claims

1. A compound insecticidal composition containing dinotefuran is characterized by being prepared by compounding dinotefuran and transfluthrin/transfluthrin, wherein the weight ratio of dinotefuran to transfluthrin is 1: 15-15: 1, the weight ratio of dinotefuran to transfluthrin is 1: 15-15: 1.

2. the compound insecticidal composition according to claim 1, wherein the weight ratio of dinotefuran to transfluthrin is 1: 4-8: 1.

3. the compound insecticidal composition according to claim 1, wherein the weight ratio of dinotefuran to transfluthrin is 1: 3-8: 1.

4. a compound insecticide containing dinotefuran is in the form of an aqueous emulsion and is characterized by being prepared from the compound insecticide composition containing dinotefuran of claim 1, a solvent, an emulsifier, an antifreezing agent, a defoaming agent and water, wherein the weight percentages of the compound insecticide composition, the solvent, the emulsifier, the antifreezing agent, the defoaming agent and the water in the total weight of the aqueous emulsion are as follows: 5 to 20 percent of compound insecticidal composition containing dinotefuran, 10 to 15 percent of solvent, 8 to 15 percent of emulsifier, 5 to 10 percent of antifreeze, 0.1 to 0.5 percent of defoamer and water to make up to 100 percent.

5. The formulation of the compound insecticide containing dinotefuran is microemulsion, and the compound insecticide is characterized in that the compound insecticide composition containing dinotefuran and solvent, cosolvent, emulsifier and water are used as raw materials to prepare the compound insecticide composition, and the weight percentages of the compound insecticide composition and the solvent, the cosolvent, the emulsifier and the water in the total weight of the microemulsion are as follows: 5 to 15 percent of compound insecticidal composition containing dinotefuran, 10 to 15 percent of solvent, 5 to 10 percent of cosolvent, 10 to 20 percent of emulsifier and water to complement to 100 percent.

6. The use of the dinotefuran-containing compound pesticide as claimed in any one of claims 4 or 5 for controlling public health pests.

7. Use according to claim 6, wherein the public health pests are mosquitoes and flies.

8. The application of claim 6, wherein the dinotefuran-containing compound pesticide is applied in the form of spatial spraying when controlling public health pests, and the aqueous emulsion is diluted by 30-200 times with water, and the microemulsion is diluted by 30-200 times with water and then sprayed in the space.