CN110637822B - Binary sanitary insecticidal composition containing oxadixyl and application thereof - Google Patents
Binary sanitary insecticidal composition containing oxadixyl and application thereof Download PDFInfo
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- CN110637822B CN110637822B CN201911037404.7A CN201911037404A CN110637822B CN 110637822 B CN110637822 B CN 110637822B CN 201911037404 A CN201911037404 A CN 201911037404A CN 110637822 B CN110637822 B CN 110637822B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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Abstract
The invention relates to a binary sanitary insecticidal composition containing famoxadone and application thereof, wherein the active ingredients are famoxadone and pyrethroid insecticides, and the total content (mass percentage) of the famoxadone and the pyrethroid insecticides is 2-80%; the weight ratio of the famoxadone to the pyrethroid insecticide is 1: 30-30: 1. The composition has good control effect on sanitary pests with resistance to pyrethroid insecticides, and the control effect is improved. In addition, the insecticide compounding of the two different action mechanisms can also delay the generation of resistance, and a new method is provided for preventing and controlling sanitary pests and delaying the resistance.
Description
Technical Field
The invention relates to a binary sanitary insecticidal composition containing famoxadone and application thereof.
Background
For a long time, most of retention spraying agents used for public health pests are pyrethroid insecticides, and the long-term use of the pyrethroid insecticides causes the health pests such as mosquitoes, flies, cockroaches and the like to generate different degrees of resistance to pyrethrins, particularly in southern China, the resistance rising speed is high, so that the control effect of the health pests is greatly reduced.
The oxadixic ketone has contact poisoning and stomach poisoning effects, and has good knockdown activity. It has the dual properties of inhibiting acetylcholinesterase and acting on nerve axons.
We considered to develop a novel knock-down agent in combination with a pyrethroid insecticide for controlling sanitary pests, for solving the problem of resistance of the sanitary pests to pyrethroids. Tests show that the resistance problem can be solved by compounding the oxadixic ketone and the pyrethroid insecticide, on one hand, the oxadixic ketone and the existing pyrethroid insecticide have different action mechanisms from the action mechanism, so that the cross resistance does not exist, the control effect is improved, and the dosage is reduced; on the other hand, the irritation of the famoxadone is less than that of a pyrethroid insecticide, so that the safety of an applicator is improved, and the insecticide compounding of the famoxadone and the pyrethroid insecticide with different action mechanisms can delay the generation of pest resistance.
Disclosure of Invention
The invention aims to solve the technical problem of the prior art and provides a binary sanitary insecticidal composition containing famoxadone, the active ingredients of which are famoxadone and pyrethroid, on one hand, the compounding of the famoxadone and the pyrethroid can solve the drug resistance of sanitary pests to pyrethroid insecticides, improve the control effect and reduce the dosage, on the other hand, the famoxadone has small irritation and improves the safety to a pesticide applicator, and the compounding of the famoxadone and the pyrethroid with different action mechanisms can delay the generation of resistance.
In order to achieve the purpose, the invention adopts the following technical scheme:
a binary sanitary insecticidal composition containing famoxadone comprises the effective components of famoxadone and pyrethroid insecticide, wherein the total content (mass percentage) of the famoxadone and the pyrethroid insecticide is 2-80%, and the balance of an auxiliary agent.
In the technical scheme, the weight ratio of the famoxadone to the pyrethroid insecticide is 1: 30-30: 1.
In the technical scheme, the pyrethroid pesticide is any one of beta-cypermethrin, deltamethrin, alpha-cypermethrin, lambda-cyhalothrin and beta-cyfluthrin.
In the technical scheme, the weight ratio of the famoxadone to the beta-cypermethrin is preferably 3: 1-1: 15.
In the technical scheme, the weight ratio of the famoxadone to the deltamethrin is further preferably 2: 1-1: 18.
In the technical scheme, the auxiliary agent is selected from a dispersing agent, a wetting agent, a disintegrating agent, a filler, an antifreezing agent, a preservative, a defoaming agent, a thickening agent and water.
In the above technical scheme, the dispersant is selected from any one of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensate, sulfate, alkylbenzene sulfonate calcium salt, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene ester, and glycerin fatty acid ester polyoxyethylene ether, or a mixture of two or more thereof mixed at any ratio.
In the above technical solution, the wetting agent is selected from: the formaldehyde condensate sulfate of alkylphenol polyoxyethylene ether, phosphate of alkylbenzene polyoxyethylene ether, phosphate of phenethyl phenol polyoxyethylene ether, alkyl sulfate, alkyl sulfonate, naphthalene sulfonate, sodium dodecyl sulfate, nekal BX, wetting penetrant F and dodecyl benzene sulfonic acid, or a mixture of two or more of them mixed in any proportion.
In the above technical scheme, the disintegrating agent is selected from: any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate and sodium sulfate, or a mixture of two or more of them in any proportion.
In the above technical solution, the filler is selected from: kaolin, white carbon black, corn starch, ammonium sulfate, sodium sulfate, attapulgite, calcium carbonate and diatomite, or a mixture of two or more of the above materials mixed in any proportion.
In the technical scheme, the antifreezing agent is any one of ethylene glycol, propylene glycol, glycerol and urea, or a mixture of two or more of the ethylene glycol, the propylene glycol, the glycerol and the urea in any proportion.
In the technical scheme, the preservative is any one of sodium benzoate, benzoic acid, potassium sorbate and kasong, or a mixture of two or more of the sodium benzoate, the benzoic acid, the potassium sorbate and the kasong which are mixed in any proportion.
In the technical scheme, the defoaming agent is any one of a silicone compound, silicone oil, a C8-10 fatty alcohol compound and a C10-20 saturated fatty acid compound, or a mixture of two or more of the silicone compound, the silicone oil, the C8-10 fatty alcohol compound and the C10-20 saturated fatty acid compound in any proportion.
In the above technical scheme, the thickener is any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, organic bentonite and white carbon black, or a mixture of two or more of the components mixed in any proportion.
In the technical scheme, the binary hygienic insecticidal composition is in the form of wettable powder, suspending agent, water dispersible granule or dry suspending agent. The preparation can be carried out according to conventional or existing methods in the field.
The invention also provides application of the binary sanitary insecticidal composition in the aspect of preventing and controlling sanitary pests.
In the technical scheme, the sanitary pests refer to culex pipiens pallens, culex fatigues, culex tritaeniorhynchus, aedes albopictus, aedes aegypti, anopheles sinensis, aedes perna, aedes volvatus, houseflies, city flies, chrysomyia megacephala, lucilia cuprina, lucilia, summer latrine flies, Yuan flies, blattella germanica and periplaneta americana.
In the technical scheme, the sanitary insect pests are preferably culex pipiens pallens, aedes albopictus, aedes aegypti, anopheles sinensis, houseflies, city flies, lucilia sericata, lucilia cuprina, german cockroaches and periplaneta americana which have resistance to the pyrethroid insecticides.
In the technical scheme, when the binary sanitary insecticidal composition is used for preventing and controlling sanitary pests, the use method comprises the following steps: the binary sanitary insecticidal composition is diluted by 200-fold and 400-fold with water and sprayed on the surfaces of walls, doors, windows, ceilings, houses and the like, so that the binary sanitary insecticidal composition is remained on the surfaces of the objects such as the walls, the doors, the windows, the ceilings, the houses and the like, and sanitary pests are knocked down and die.
The binary sanitary insecticidal composition has good control effect on sanitary pests with resistance to pyrethroid insecticides, and the control effect is improved; in addition, the insecticide compounding of the two different action mechanisms can also delay the generation of resistance, and a new method is provided for preventing and controlling sanitary pests and delaying the resistance. The binary hygienic insecticidal composition can well control culex pipiens pallens and houseflies in Shenzhen.
Detailed Description
The following detailed description of the embodiments of the present invention is provided, but the present invention is not limited to the following descriptions:
in the embodiment of the invention, the preparation method of each dosage form comprises the following steps:
the laboratory preparation method of the wettable powder comprises the following steps: adding the famoxadone, the pyrethroid insecticide, the wetting agent, the dispersing agent and the filler into a food processor, uniformly mixing, and then feeding into a jet mill for crushing to obtain the pesticide.
The laboratory preparation method of the suspending agent comprises the following steps: weighing wetting agent, dispersant, antifreeze, preservative, defoamer and water according to the proportion, adding into a beaker, mixing uniformly, adding the oxadixyl and the pyrethroid insecticide into the beaker, transferring to a sand mill, adding zirconia beads into the sand mill, grinding for 2-3h, adding the thickener, and continuously grinding for 0.5h to ensure that the particle diameter D is95Controlling the particle size below 5 microns, and filtering to remove zirconia beads to obtain the product.
The laboratory preparation method of the water dispersible granule comprises the following steps: adding the famoxadone, the pyrethroid insecticide, the wetting agent, the dispersing agent, the disintegrating agent and the filler into a food processor, uniformly mixing, then crushing in a jet mill, mixing again in the food processor, adding a proper amount of water, and finally extruding and granulating by a granulator to obtain the pesticide composition.
The laboratory preparation method of the dry suspending agent comprises the following steps: weighing wetting agent, dispersant, defoamer, filler and water according to the proportion, adding the wetting agent, the dispersant, the defoamer, the filler and the water into a beaker, uniformly mixing, adding the oxadixyl and the pyrethroid insecticide into the beaker, transferring the beaker to a sand mill, adding zirconia beads into the sand mill, and grinding for 2-3h to ensure that the particle diameter D is reduced95Controlling the particle size below 5 microns, filtering to remove zirconia beads, and drying the obtained material by a spray dryer to obtain the product.
The invention is illustrated below with reference to specific examples:
formulation example 1: 24% oxadilone-beta-cypermethrin suspension
18g of famoxadone, 6g of beta-cypermethrin, 2g of sodium dodecyl sulfate, 5g of lignosulfonate, 1g of polycarboxylate, 2g of propylene glycol, 3g of ethylene glycol, 0.5g of potassium sorbate, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 2: 16% oxadilone-beta-cypermethrin suspension
1g of famoxadone, 15g of beta-cypermethrin, 1g of alkyl sulfate, 2g of alkyl sulfonate, 1g of lignosulfonate, 6g of lignosulfonate, 2g of propylene glycol, 0.4g of potassium sorbate, 2g of urea, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 3: 40% oxadilone-beta-cypermethrin suspension
20g of famoxadone, 20g of beta-cypermethrin, 2g of alkyl benzene polyoxyethylene ether phosphate, 4g of sodium naphthalene sulfonate formaldehyde condensate, 4g of glycerol, 3g of urea, 0.5g of sodium benzoate, 1g of magnesium aluminum silicate, 0.2g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 4: 80% oxadilone and beta-cypermethrin water dispersible granule
20g of famoxadone, 60g of beta-cypermethrin, BX2g, 5g of alkyl sulfate, 2g of lignosulfonate, 4g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 2g of ammonium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.
Formulation example 5: water dispersible granule containing 40% oxadixolone and beta-cypermethrin
20g of famoxadone, 20g of beta-cypermethrin, BX4g, 2g of sodium dodecyl sulfate, 10g of sodium naphthalene sulfonate formaldehyde condensate, 3g of ammonium sulfate, 20g of corn starch and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.
Formulation example 6: water dispersible granule containing 50% oxadixolone and beta-cypermethrin
10g of famoxadone, 40g of beta-cypermethrin, BX4g, 6g of lignosulfonate, 8g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 5g of sodium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.
Formulation example 7: 8% oxadilone and beta-cypermethrin wettable powder
1g of famoxadone, 7g of beta-cypermethrin, 3g of alkyl sulfate, 5g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 8g of lignosulfonate, 5g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 8: 30% oxadilone and beta-cypermethrin wettable powder
20g of famoxadone, 10g of beta-cypermethrin, 4g of alkyl sulfate, 5g of sodium salt of a naphthalene sulfonic acid formaldehyde condensate, 5g of fatty amine polyoxyethylene ether, 8g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 9: wettable powder of 45% oxadixon and beta-cypermethrin
5g of famoxadone, 40g of beta-cypermethrin, 3g of alkyl sulfate, 2g of sodium salt of a naphthalene sulfonic acid formaldehyde condensate, 1g of polycarboxylate, 10g of fatty amine polyoxyethylene ether, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 10: 21% oxadilone and beta-cypermethrin wettable powder
1g of famoxadone, 20g of beta-cypermethrin, 2g of sodium dodecyl sulfate, 5g of fatty amine polyoxyethylene ether, 5g of sodium naphthalenesulfonic acid formaldehyde condensate, 5g of polycarboxylate, 3g of white carbon black and the balance of corn starch to 100 g. The wettable powder is prepared by the method.
Formulation example 11: 10% oxadilone-beta-cypermethrin suspension
2g of famoxadone, 8g of beta-cypermethrin, 3g of sodium dodecyl sulfate, 1g of polycarboxylate, 5g of lignosulfonate, 5g of propylene glycol, 0.5g of potassium sorbate, 1g of magnesium aluminum silicate, 0.2g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 12: 42% oxadilone and beta-cypermethrin water dispersible granule
2g of famoxadone, 40g of beta-cypermethrin, BX4g, 5g of sodium dodecyl sulfate, 10g of sodium naphthalene sulfonate formaldehyde condensate, 3g of polycarboxylate, 3g of ammonium sulfate and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.
Formulation example 13: 10% oxadixon-beta-cypermethrin dry suspending agent
2g of famoxadone, 8g of beta-cypermethrin, 5g of alkyl sulfate, 5g of sodium dodecyl sulfate, 3g of sodium naphthalenesulfonic acid formaldehyde condensate, 1g of silicone compound and the balance of corn starch to 100 g. The dry suspending agent is prepared by the method.
Formulation example 14: 27% oxadilone/deltamethrin suspension
18g of famoxadone, 9g of deltamethrin, 4g of sodium dodecyl sulfate, 5g of lignosulfonate, 2g of propylene glycol, 3g of ethylene glycol, 0.2g of potassium sorbate, 1g of magnesium aluminum silicate, 0.2g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 15: 19% oxadixolone-deltamethrin suspension
1g of famoxadone, 18g of deltamethrin, 1g of alkyl sulfate, 2g of alkyl sulfonate, 3g of polycarboxylate, 5g of lignosulfonate, 2g of propylene glycol, 0.5g of potassium sorbate, 3g of urea, 0.5g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 16: 40% oxadixon-deltamethrin suspension
20g of famoxadone, 20g of deltamethrin, 2g of alkyl benzene polyoxyethylene ether phosphate, 2g of sodium naphthalene sulfonic acid formaldehyde condensate, 4g of lignosulfonate, 5g of glycerol, 0.5g of sodium benzoate, 0.5g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 17: 80% oxadixolone-deltamethrin water dispersible granule
40g of famoxadone, 40g of deltamethrin, BX1g, 6g of alkyl sulfate, 5g of lignosulfonate, 2g of sodium sulfate, 3g of ammonium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.
Formulation example 18: 40% oxadixolone-deltamethrin water dispersible granule
30g of famoxadone, 10g of deltamethrin, 5g of nekal BX5g, 5g of sodium dodecyl sulfate, 3g of polycarboxylate, 10g of sodium naphthalene sulfonate formaldehyde condensate, 3g of ammonium sulfate and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.
Formulation example 19: water dispersible granule containing 50% oxadixolone and deltamethrin
10g of famoxadone, 40g of deltamethrin, BX2g, 5g of lignosulfonate, 10g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 6g of sodium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.
Formulation example 20: 40% oxadixolone-deltamethrin wettable powder
20g of famoxadone, 20g of deltamethrin, 3g of alkyl sulfate, 5g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 5g of lignosulfonate, 4g of polycarboxylate, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 21: 30% oxadixolone-deltamethrin wettable powder
20g of famoxadone, 10g of deltamethrin, 3g of alkyl sulfate, 5g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 5g of polycarboxylate, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 22: 41% oxadixolone-deltamethrin wettable powder
1g of famoxadone, 40g of deltamethrin, 3g of alkyl sulfate, 2g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 3g of polycarboxylate, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 23: 21% oxadixolone-deltamethrin wettable powder
1g of famoxadone, 20g of deltamethrin, 5g of fatty amine polyoxyethylene ether, 5g of sodium naphthalenesulfonic acid formaldehyde condensate, 10g of fatty amine polyoxyethylene ether, 5g of polycarboxylate, 3g of white carbon black and the balance of corn starch to 100 g. The wettable powder is prepared by the method.
Formulation example 24: 2% oxadixolone-deltamethrin suspension
1g of famoxadone, 1g of deltamethrin, 5g of sodium dodecyl sulfate, 5g of lignosulfonate, 5g of propylene glycol, 1g of potassium sorbate, 1g of magnesium aluminum silicate, 0.2g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 25: 45% oxadixolone-deltamethrin water dispersible granule
9g of famoxadone, 36g of deltamethrin, BX5g, 5g of sodium dodecyl sulfate, 10g of sodium naphthalene sulfonate formaldehyde condensate, 2g of polycarboxylate, 3g of ammonium sulfate and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.
Formulation example 26: 10% oxadixolone-deltamethrin dry suspending agent
2g of famoxadone, 8g of deltamethrin, 5g of alkyl sulfate, 5g of sodium dodecyl sulfate, 3g of sodium naphthalene sulfonate formaldehyde condensate, 2g of polycarboxylate, 1g of silicone oil and the balance of corn starch to 100 g. The dry suspending agent is prepared by the method.
Formulation example 27: 2% oxadilone-beta-cypermethrin suspension
1g of famoxadone, 1g of beta-cypermethrin, 3g of sodium dodecyl sulfate, 4g of polycarboxylate, 10g of lignosulfonate, 5g of propylene glycol, 0.5g of potassium sorbate, 2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 28: 2% oxadilone and efficient cyhalothrin suspension
1g of famoxadone, 1g of lambda-cyhalothrin, 3g of sodium dodecyl sulfate, 5g of polycarboxylate, 5g of lignosulfonate, 7g of propylene glycol, 0.5g of potassium sorbate, 2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 29: 80% oxadilone and efficient cyhalothrin water dispersible granule
10g of famoxadone, 70g of lambda-cyhalothrin, BX5g, 8g of polycarboxylate, 5g of ammonium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.
Formulation example 30: 30% oxadilone and efficient cyhalothrin wettable powder
20g of famoxadone, 10g of lambda-cyhalothrin, 3g of alkyl sulfate, 5g of sodium naphthalene sulfonic acid formaldehyde condensate, 5g of polycarboxylate, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 31: 2% oxadilone-beta-cyfluthrin suspension
1g of famoxadone, 1g of beta-cyfluthrin, 4g of sodium dodecyl sulfate, 3g of polycarboxylate, 9g of lignosulfonate, 7g of propylene glycol, 0.5g of potassium sorbate, 2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 32: 80% oxadilone and beta-cyfluthrin water dispersible granule
10g of famoxadone, 70g of beta-cyfluthrin, 5g of sodium dodecyl sulfate, 7g of polycarboxylate, 5g of ammonium sulfate and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.
Formulation example 33: 24% oxadilone and high-efficiency cyfluthrin wettable powder
6g of famoxadone, 18g of beta-cyfluthrin, 3g of sodium dodecyl sulfate, 5g of sodium naphthalene sulfonate formaldehyde condensate, 5g of polycarboxylate, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.
Formulation example 34: 10% oxadilone-beta-cyfluthrin suspension agent
1g of famoxadone, 9g of beta-cyfluthrin, 4g of sodium dodecyl sulfate, 9g of lignosulfonate, 4g of propylene glycol, 2g of ethylene glycol, 1g of potassium sorbate, 1g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 35: 31% oxadilone-beta-cypermethrin suspension
1g of famoxadone, 30g of beta-cypermethrin, 2g of sodium dodecyl sulfate, 3g of lignosulfonate, 2g of polycarboxylate, 4g of propylene glycol, 2g of ethylene glycol, 1g of potassium sorbate, 1g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 36: 31% oxadilone-beta-cypermethrin suspension
30g of famoxadone, 1g of beta-cypermethrin, 2g of sodium dodecyl sulfate, 3g of lignosulfonate, 2g of polycarboxylate, 4g of propylene glycol, 2g of ethylene glycol, 1g of potassium sorbate, 1g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 37: 15% oxadilone-cis-cypermethrin suspension
1g of famoxadone, 14g of cis-cypermethrin, 3g of alkyl sulfate, 1g of alkyl sulfonate, 1g of lignosulfonate, 6g of lignosulfonate, 2g of propylene glycol, 0.4g of potassium sorbate, 2g of urea, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and the balance of water to 100 g. The suspending agent is prepared by the method.
Formulation example 38: 40% oxadilone-cis-cypermethrin suspension
20g of famoxadone, 20g of cis-cypermethrin, 2g of alkyl benzene polyoxyethylene ether phosphate, 3g of sodium naphthalene sulfonate formaldehyde condensate, 3g of lignosulfonate, 4g of glycerol, 3g of urea, 0.5g of sodium benzoate, 1g of magnesium aluminum silicate, 0.2g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.
Formulation example 39: water dispersible granule containing 40% oxadixolone and cis-cypermethrin
10g of famoxadone, 30g of cis-cypermethrin, BX4g, 2g of sodium dodecyl sulfate, 5g of sodium naphthalene sulfonate formaldehyde condensate, 6g of ammonium sulfate, 20g of corn starch and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.
Formulation example 40: wettable powder of 50% oxadixon-cis-cypermethrin
10g of famoxadone, 40g of cis-cypermethrin, BX5g, 8g of lignosulfonate, 2g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 5g of sodium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.
The product obtained from each formulation example of the invention was tested for validation, control 1: 10% of efficient cyhalothrin wettable powder (sold in the market); control agent 2: 10% wettable powder of beta-cypermethrin (commercially available).
Verification test 1: shenzhen wild culex pipiens pallens and housefly resistance level determination
(1) Test subjects: the first generation of breeding culex pipiens pallens and Shenzhen wild culex pipiens in the laboratory, the first generation of breeding houseflies in the laboratory and the first generation of breeding houseflies in the Shenzhen wild in the laboratory
(2) The test method comprises the following steps: reference to indoor bioassay test criteria for pesticides part one: and (3) a contact killing activity test, namely performing an activity determination test on culex pipiens pallens and houseflies by adopting a dropping method NY/T1154.1-2006.
(3) Test agents: high-efficiency cypermethrin technical
(4) And (3) test results:
TABLE 1 Activity data of Culex pipiens and Musca domestica in the laboratory and Shenzhen wild
As can be seen from the table above, the multiple of resistance of Shenzhen wild culex pipiens pallens to the beta-cypermethrin is 79 times that of the laboratory, and the multiple of resistance of Shenzhen wild houseflies to the beta-cypermethrin is 53 times that of the laboratory. The culex pipiens and houseflies collected from Shenzhen wild are called wild resistant strain for short below.
Verification test 2:
(1) test subjects: the first generation of breeding culex pipiens pallens and Shenzhen wild culex pipiens in the laboratory, the first generation of breeding houseflies in the laboratory and the first generation of breeding houseflies in the Shenzhen wild in the laboratory
(2) The test method comprises the following steps: refer to GB/T13919.1-2009 pesticide registration sanitary insecticide indoor pesticide effect test and evaluation, retention spray test.
(3) Test agents: 10% efficient cypermethrin wettable powder
(4) And (3) test results:
TABLE 2 laboratory and Shenzhen wild Culex pipiens, Musca domestica retention spray data
As can be seen from the retention spray test data of table 2: shenzhen wild KT of culex pipiens pallens and houseflies50Is obviously higher than the strain in the laboratory, and proves that the Shenzhen strain generates resistance to the beta-cypermethrin.
Verification test 3: co-toxicity coefficient of famoxadone, beta-cypermethrin and deltamethrin to culex pipiens pallens
(1) Test subjects: light culex (laboratory feeding)
(2) The test method comprises the following steps: reference to indoor bioassay test criteria for pesticides part one: and (3) a contact killing activity test, namely performing an activity determination test on culex pipiens pallens by adopting a dropping method NY/T1154.1-2006.
(3) And (3) data statistics: the activity of the combination of the two on culex pipiens pallens is evaluated by adopting a co-toxicity coefficient method. Then calculating toxicity regression equation by DPS statistical software to obtain LD of each medicine50And calculating the virulence index and the cotoxicity coefficient of the medicament according to the Sun cloud Pepper method. The co-toxicity coefficient is more than 120 to show the synergistic effect, the co-toxicity coefficient is between 80 and 120 to show the additive effect, and the co-toxicity coefficient is less than 80 to show the antagonistic effect. The results of the measurements are shown in the following table:
TABLE 3 Co-toxicity coefficient of famoxadone and beta-cypermethrin against Culex pipiens pallens
As can be seen from table 3: oxadilone: the co-toxicity coefficient of the beta-cypermethrin is greater than 120 at the ratio of 3: 1-1: 15, and the beta-cypermethrin is synergistic.
TABLE 4 Co-toxicity coefficient of famoxadone and deltamethrin against Culex pipiens pallens
As can be seen from table 4: oxadilone: the co-toxicity coefficient of deltamethrin is more than 120 under the proportion of 2: 1-1: 18, and the deltamethrin is synergistic.
Verification test 4: drug effect test for preventing and controlling retention of mosquitoes and flies
(1) Test subjects: culex pipiens pallens and housefly (first generation of field resistant line breeding)
(2) The test method comprises the following steps: refer to GB/T13919.1-2009 pesticide registration sanitary insecticide indoor pesticide effect test and evaluation, retention spray test.
(3) Test agents: formulation examples 1, 2, 4, 5, 9, 10, 13, 14, 15, 17, 21, 24, 26, 28, 33, 38, 39 were all diluted to 900ppm with water, and control agents 1 and 2 were diluted to 900ppm with water.
(4) And (3) data statistics:
TABLE 5 data of several treatments for efficacy tests against culex pipiens pallens and houseflies
As can be seen from Table 5, several examples of how famoxadone was formulated with beta-cypermethrin, deltamethrin, alpha-cypermethrin, beta-cyhalothrin were formulated against KT of culex pipiens pallens and houseflies resistant to50Values were less than 7 minutes and 24 hours mortality was greater than 85%, while controls 1 and 2 KT against resistant culex pipiens pallens and houseflies50The values are all greater than 16 minutes, and the 24-hour mortality is all less than or equal to 80%. Therefore, the famoxadone is compounded with the beta-cypermethrin, the deltamethrin, the alpha-cypermethrin, the beta-cyhalothrin and the beta-cyhalothrin, and a detention spraying mode is adopted to have good control effect on the culex pipiens pallens and the houseflies with resistance to the pyrethroid.
The above examples are only for illustrating the technical concept and features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (4)
1. A binary sanitary insecticidal composition containing famoxadone is characterized in that: the active ingredients are the oxadixic ketone and the pyrethroid insecticide, and the total content of the oxadixic ketone and the pyrethroid insecticide is 2 to 80 percent;
the pyrethroid insecticide is deltamethrin; the weight ratio of the famoxadone to the deltamethrin is 2: 1-1: 18.
2. Binary sanitary insecticidal composition according to claim 1, characterized in that: the binary hygienic insecticidal composition is in the dosage form of wettable powder, suspending agent, water dispersible granules or dry suspending agent.
3. The use of the binary sanitary insecticidal composition according to claim 1 for controlling sanitary pests, wherein said sanitary pests are culex pipiens, culex fatigues, culex tritaeniorhynchus, aedes albopictus, aedes aegypti, anopheles sinensis, aedes infestans, midge mosquitoes, crickets, city flies, chrysomyia megacephala, lucilia sericata, lucilia cuprina, lucilia, lucilia subulata, and metalatus domestica.
4. Use according to claim 3, characterized in that: when the binary sanitary insecticidal composition is used for preventing and controlling sanitary pests, the use method comprises the following steps: the binary sanitary insecticidal composition is diluted by 200 times and 400 times by water and sprayed on the surfaces of walls, doors, windows, ceilings and houses, so that the binary sanitary insecticidal composition is remained on the surfaces of the walls, the doors, the windows, the ceilings and the houses, and sanitary pests are knocked down and killed.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1192312A (en) * | 1997-07-24 | 1999-04-06 | Dainippon Jochugiku Co Ltd | Smoking insecticide and smoking |
| JP2006028173A (en) * | 2004-06-17 | 2006-02-02 | Lion Corp | Preventive/insecticidal composition against unpleasant vermin and preventive/insecticidal method |
| CN103766391A (en) * | 2012-10-25 | 2014-05-07 | 狮王株式会社 | Fumigating insecticide and fumigating insecticidal device |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1192312A (en) * | 1997-07-24 | 1999-04-06 | Dainippon Jochugiku Co Ltd | Smoking insecticide and smoking |
| JP2006028173A (en) * | 2004-06-17 | 2006-02-02 | Lion Corp | Preventive/insecticidal composition against unpleasant vermin and preventive/insecticidal method |
| CN103766391A (en) * | 2012-10-25 | 2014-05-07 | 狮王株式会社 | Fumigating insecticide and fumigating insecticidal device |
Non-Patent Citations (1)
| Title |
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| 三光气法合成噁虫酮的工艺;朱建荣等;《农药》;20150610;第54卷(第6期);400、402 * |
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