CN116406673A - Sanitary insecticidal composition containing oxacarb and pyrethroid - Google Patents

Sanitary insecticidal composition containing oxacarb and pyrethroid Download PDF

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CN116406673A
CN116406673A CN202111635648.2A CN202111635648A CN116406673A CN 116406673 A CN116406673 A CN 116406673A CN 202111635648 A CN202111635648 A CN 202111635648A CN 116406673 A CN116406673 A CN 116406673A
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sanitary
percent
pyrethroid
insecticidal composition
oxadiazon
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吴孝举
王宝林
陈麒丞
贾炜
田大军
章超
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Jiangsu Yangnong Chemical Co Ltd
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Jiangsu Yangnong Chemical Co Ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/22O-Aryl or S-Aryl esters thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a sanitary insecticidal composition containing oxadiazon and pyrethroid, wherein the effective components are the oxadiazon and the pyrethroid, and the sanitary insecticidal composition comprises the following components: the content of the oxadiazon is 1-15%, the content of the pyrethroid is 1-5%, and the balance is auxiliary agent; the sanitary insecticidal composition is in the form of emulsifiable concentrate, microemulsion and soluble liquid. The sanitary insecticidal composition has the characteristics of high efficiency, low toxicity, environmental friendliness and the like. The compound pesticide is used for space spraying, is quick to knock down, has high mortality, reduces the application times, reduces the labor cost, and accords with the national policy direction of synergy and application reduction; and pesticides with different action mechanisms are compounded, so that the comprehensive pest control can be performed. Can be applied to hotels, schools, factories, families, farmers and public places for preventing and controlling mosquito, fly, cockroach and other sanitary pests.

Description

Sanitary insecticidal composition containing oxacarb and pyrethroid
Technical Field
The invention relates to a sanitary insecticidal composition, in particular to a sanitary insecticidal composition containing oxadiazon and pyrethroid, and the effective components of the sanitary insecticidal composition are the oxadiazon and the pyrethroid, belonging to the technical field of sanitary insecticidal.
Background
For a long time, the pyrethroid insecticide is widely applied to the prevention and treatment of public health pests, and the sanitary pests such as mosquitoes, flies and the like generate different degrees of drug resistance to the pyrethroid insecticide, especially in southern China, the resistance rising speed is higher, so that the prevention and treatment effect of the sanitary pests is greatly reduced.
The oxadiazon belongs to carbamate pesticide, is cholinesterase inhibitor, and has the functions of killing and regulating stomach toxin, and has the features of high lethal activity, long lasting period, etc.
Experiments show that the combination of the oxadiazon and part of the pyrethroid insecticide has synergistic effect, so that the pesticide usage amount is reduced, and the interaction resistance is not existed in different action mechanisms of the oxadiazon and the pyrethroid hygienic insecticide from the action mechanism, so that the control effect is improved, and the pesticide combination of the oxadiazon and the pyrethroid insecticide with different action mechanisms can delay the drug resistance of pests, thereby being beneficial to the resistance control of the pests. The compound agent is developed into a water-removing emulsion, a microemulsion and a soluble liquid agent which are used for space spraying to prevent and treat sanitary pests such as mosquitoes and flies, and the compound agent is different from the existing registered oxadiazon wettable powder which is used for detention spraying, so that the oxadiazon space spraying agent and the using method thereof are developed.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides the sanitary insecticidal composition containing the oxadiazon and the pyrethroid, which has the effective components of the oxadiazon and the pyrethroid, so that the pesticide usage amount is reduced on one hand, and on the other hand, from the action mechanism, the oxadiazon is different from the action mechanism of the existing pyrethroid sanitary insecticide, the interaction resistance does not exist, the control effect is improved, the pesticide compounding of the different action mechanisms of the oxadiazon and the pyrethroid can delay the drug resistance of pests, and the resistance control of the pests is facilitated.
In order to achieve the above purpose, the present invention adopts the following technical scheme (if no special description exists, the content in the present invention refers to weight percentage):
a sanitary insecticidal composition containing oxacarb and pyrethroid, the effective components are the oxacarb and the pyrethroid, wherein: the content of the oxadiazon is 1-15%, the content of the pyrethroid is 1-5%, and the balance is auxiliary agent; the sanitary insecticidal composition is in the form of emulsifiable concentrate, microemulsion and soluble liquid.
In the technical scheme, the total content of the oxadiazon and the pyrethroid is 2-20%.
In the above technical solution, the pyrethroid is selected from: any one of tefluthrin, bifenthrin, tefluthrin, bifenthrin, prallethrin, tefluthrin, and allethrin.
In the technical scheme, the weight ratio of the oxadiazon to the pyrethroid is 15:1-1:1.
In the technical scheme, when the pyrethroid is the tetrafluoromethyl ether pyrethroid, the weight ratio of the oxadiazon to the tetrafluoromethyl ether pyrethroid is preferably 9:1-3:1.
In the technical scheme, when the pyrethroid is bifenthrin, the weight ratio of the oxadiazon to the bifenthrin pesticide is preferably 8:1-2:1.
In the technical scheme, when the pyrethroid is bifenthrin, the weight ratio of the oxadiazon to the bifenthrin insecticide is preferably 6:1-1:1.
In the technical scheme, the auxiliary agent is a mixture formed by mixing three or four of a solvent, an emulsifying agent, a space spraying slow release agent and deionized water according to any proportion.
In the technical scheme, when the formulation of the sanitary insecticidal composition is emulsifiable concentrate, the auxiliary agent is an emulsifying agent, a space spraying slow release agent and a solvent, and the contents of the components are as follows: 1 to 15 percent of oxadiazon, 1 to 5 percent of pyrethroid, 5 to 20 percent of emulsifier, 1 to 30 percent of space spraying sustained release agent and the complement of solvent to 100 percent.
In the technical scheme, when the formulation of the sanitary insecticidal composition is microemulsion, the auxiliary agent is an emulsifier, a space spraying slow release agent, a solvent and deionized water, and the contents of the components are as follows: 1 to 15 percent of oxadiazon, 1 to 5 percent of pyrethroid, 10 to 30 percent of emulsifier, 1 to 10 percent of space spraying sustained release agent, 1 to 30 percent of deionized water and the balance of solvent to 100 percent.
In the technical scheme, when the formulation of the sanitary insecticidal composition is a soluble liquid, the auxiliary agent is an emulsifying agent, a space spraying slow release agent and a solvent, and the contents of the components are as follows: 1 to 15 percent of oxadiazon, 1 to 5 percent of pyrethroid, 5 to 20 percent of emulsifier, 1 to 30 percent of space spraying sustained release agent and the complement of solvent to 100 percent.
In the above technical solution, the solvent is selected from: any one of trimethylbenzene, ethanol, N-dimethylformamide, N-dimethylacetamide, N-dimethylsunflower amide, cyclohexanone, N-methylpyrrolidone, N-octylpyrrolidone, dimethyl sulfoxide, propanol, butanol, ethylene glycol, isopropanol, diethylene glycol, ethylene glycol methyl ether, piperonyl butyl ether, dodecylbenzene, butyl ether, ethyl acetate, dimethyl phthalate, diethyl phthalate and dibutyl phthalate, and a mixture of two or more of them in any ratio.
In the above technical scheme, the space spraying sustained release agent is selected from the group consisting of: and a mixture of two or more of dimethyl 2-methylglutarate, dimethyl succinate, N-dimethylpropionamide and propylene carbonate mixed in any proportion.
In the above technical solution, the emulsifier is selected from: any one of styrylphenol polyoxyethylene ether, calcium alkyl benzene sulfonate, phenylphenol polyoxyethylene ether phosphate, styrene polyoxyethylene ether ammonium sulfate, alkyl diphenyl ether disulfonate, triethanolamine salt, benzyl dimethyl phenol polyoxyethylene ethyl ether, phenethyl phenol formaldehyde resin polyoxyethylene ethyl ether, phenethyl phenol polyoxyethylene polypropylene glycol ether, ethylene oxide-propylene oxide block copolymer, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylaryl polyoxypropylene polyoxyethylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, span 60, span 80, tween 60, tween 80 and fatty alcohol polyoxyethylene ether, and a mixture of two or more of them in any proportion.
In the technical scheme, when the formulation of the sanitary insecticidal composition is missible oil, microemulsion and soluble liquid, the sanitary insecticidal composition is prepared according to a conventional method or an existing method in the field.
The invention also provides an application of the sanitary insecticidal composition in the aspect of preventing and controlling sanitary pests.
In the technical scheme, the sanitary insect pests refer to culex pallidum, culex tiredness, culex trilobata, aedes albopictus, aedes aegypti, anopheles sinensis, albopictus, midge, housefly, chrysomyia megacephala, lucilia sericata, copperus, liriomyza sativae, campylomyza sativae, german cockroach, american cockroach, bed bugs, fleas, all-ditch hard ticks, chinese hard ticks, prairie hard ticks, small cattle ticks, leather mites and scabies.
In the technical scheme, when the sanitary insecticidal composition is used for preventing and controlling sanitary pests, the sanitary insecticidal composition is diluted by 30-200 times by water and then sprayed into spaces of hotels, schools, factories, families and public places, so that the sanitary pests are contacted with the medicament when moving in the application space, and the aim of preventing and controlling the sanitary pests is fulfilled.
The sanitary insecticidal composition disclosed by the invention is aimed at emulsifiable concentrates, microemulsions and soluble liquid, is added with a space spraying slow-release agent, improves the spraying effect, reduces the size of liquid drops in space spraying, prolongs the diffuse residence time in space, and is quick in knockdown, high in mortality, low in application frequency, low in labor cost and in accordance with the national policy direction of synergy and application reduction.
Detailed Description
The following detailed description of the technical scheme of the present invention is provided, but the present invention is not limited to the following descriptions:
the preparation method of the dosage form in each embodiment of the invention comprises the following steps:
the laboratory preparation method of the emulsifiable concentrate comprises the following steps: the oxadiazon, the pyrethroid, the emulsifier, the space spraying slow release agent and the solvent are weighed according to the proportion, and the emulsifiable concentrate can be prepared after the mixture is heated to 40-50 ℃ and fully dissolved.
The laboratory preparation method of the microemulsion comprises the following steps: the method comprises the steps of weighing the oxadiazon, the pyrethroid, the emulsifier, the space spraying sustained release agent and the solvent according to the proportion, heating to 40-50 ℃, and fully dissolving with deionized water to obtain the microemulsion.
The laboratory preparation method of the soluble liquid comprises the following steps: the oxadiazon, the pyrethroid, the emulsifier, the space spraying slow release agent and the solvent are weighed according to the proportion, heated to 40-50 ℃ and fully dissolved, thus obtaining the soluble liquid.
The invention is illustrated below with reference to specific examples.
Formulation example 1:7% oxadiazon-tetrafluoro methyl ether pyrethrin emulsifiable concentrate
6% of bendiocarb, 1% of tetrafluoromethyl ether pyrethrin, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenyl phenol polyoxyethylene ether phosphate, 10% of propylene carbonate and 100% of dodecylbenzene.
Formulation example 2:8% oxadiazon-tetrafluoromethyl ether pyrethrin microemulsion
6% of bendiocarb, 2% of tetrafluoromethyl ether pyrethrin, 6% of styrene polyoxyethylene ether ammonium sulfate, 6% of alkyl diphenyl ether disulfonate magnesium salt, 5% of dimethyl succinate, 10% of deionized water, 10% of dodecylbenzene and 100g of trimethylbenzene.
Formulation example 3: soluble liquid of 10% oxadiazon-tetrafluoromethyl ether pyrethrin
9% of bendiocarb, 1% of tetrafluoromethyl ether pyrethrin, 5% of calcium alkyl benzene sulfonate, 12% of castor oil polyoxyethylene ether, 10% of N, N-dimethyl propionamide, 2% of piperonyl butoxide, 10% of cyclohexanone and the balance of dimethyl sulfoxide to 100%.
Formulation example 4:6% oxacarb-bifenthrin emulsifiable concentrate
5% of benflumetofen, 1% of bifenthrin, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenylphenol polyoxyethylene ether phosphate, 15% of dimethyl 2-methylglutarate and 100% of dodecylbenzene.
Formulation example 5:9% oxacarb-bifenthrin microemulsion
8% of benflumetofen, 1% of bifenthrin, 8% of triethanolamine salt, 3% of benzyl dimethyl phenol polyoxyethylene ether, 8% of propylene carbonate, 30% of deionized water, 15% of ethylene glycol and 100% of dodecylbenzene.
Formulation example 6:15% oxacarb-bifenthrin soluble liquid
10% of benflumetofen, 5% of bifenthrin, 5% of calcium alkyl benzene sulfonate, 12% of castor oil polyoxyethylene ether, 10% of dimethyl sulfoxide, 2% of piperonyl butoxide, 13% of N, N-dimethyl propionamide and 100% of N-methylpyrrolidone.
Formulation example 7:8% benflumetofen-methoprene emulsifiable concentrate
6% of benflumetofen, 2% of methoprene, 3% of calcium alkyl benzene sulfonate, 6% of polyoxyethylene ether of phenethyl phenol formaldehyde resin, 1% of polyoxyethylene ether phosphate of phenylphenol, 10% of dimethyl 2-methylglutarate and 100% of dodecylbenzene.
Formulation example 8:10% benflumetofen microemulsion
9% of benflumetofen, 1% of bifenthrin, 5% of benzyl dimethyl phenol polyoxyethylene ether, 10% of phenethyl phenol formaldehyde resin polyoxyethylene ether, 5% of dimethyl succinate, 15% of deionized water, 5% of dibutyl phthalate and 100% of trimethylbenzene.
Formulation example 9:35% oxadiazon-methoprene soluble liquid
30% of benflumetofen, 5% of methoprene, 4% of calcium alkyl benzene sulfonate, 15% of castor oil polyoxyethylene ether, 13% of N, N-dimethyl propionamide, 2% of piperonyl butoxide and 100% of dimethyl sulfoxide.
Formulation example 10:8% oxadiazon-transfluthrin emulsifiable concentrate
6% of benflumetofen, 2% of transfluthrin, 2% of calcium alkyl benzene sulfonate, 5% of polyoxyethylene phenethyl phenol formaldehyde resin, 1% of polyoxyethylene phenyl ether phosphate, 15% of dimethyl 2-methylglutarate, 1% of propylene carbonate and 100% of dodecylbenzene.
Formulation example 11:12% oxadiazon-transfluthrin microemulsion
6% of benflumetofen, 6% of transfluthrin, 4% of phenethyl phenol polyoxyethylene polypropylene ether, 4% of ethylene oxide-propylene oxide block copolymer, 4% of styrylphenol polyoxyethylene ether, 4% of dimethyl succinate, 15% of deionized water, 15% of butyl ether and 100% of dodecylbenzene.
Formulation example 12:14% oxadiazon-transfluthrin soluble liquid
12% of benflumetofen, 2% of transfluthrin, 5% of calcium alkyl benzene sulfonate, 15% of castor oil polyoxyethylene ether, 11% of N, N-dimethyl propionamide, 2.5% of piperonyl butoxide and the balance of N-methylpyrrolidone to 100%.
Formulation example 13:10% oxadiazon-tetrafluoro ethofenprox emulsifiable concentrate
8% of bendiocarb, 2% of transfluthrin, 3% of calcium alkyl benzene sulfonate, 6% of polyoxyethylene ether of phenethyl phenol formaldehyde resin, 1% of polyoxyethylene ether phosphate of phenylphenol, 10% of dimethyl 2-methylglutarate, 5% of ethanol and the balance of trimethylbenzene to 100%.
Formulation example 14:14% oxacarb-tetrafluoroethrin microemulsion
12% of benoxacarb, 2% of transfluthrin, 5% of alkylaryl polyoxypropylene polyoxyethylene ether, 805% of tween, 1% of propylene carbonate, 10% of deionized water, 10% of N-octyl pyrrolidone and the balance of dimethyl sulfoxide to 100%.
Formulation example 15:15% oxadiazon-tetrafluorotetramethrin soluble liquid
10% of benoxacarb, 5% of transfluthrin, 3% of calcium alkyl benzene sulfonate, 6% of styrene polyoxyethylene ether ammonium sulfate, 1% of phenylphenol polyoxyethylene ether phosphate, 5% of dimethyl 2-methylpentanedioate, 5% of dimethyl succinate, 5% of ethanol and the balance of N-methylpyrrolidone.
Formulation example 16:7% oxadiazon-dextro trans-chlorpropynyl pyrethroid emulsifiable concentrate
6% of bendiocarb, 1% of dextral trans-chlorpropynyl, 3% of calcium alkyl benzene sulfonate, 6% of phenethyl phenol formaldehyde resin polyoxyethylene ether, 1% of phenylphenol polyoxyethylene ether phosphate, 10% of propylene carbonate and the balance of dodecylbenzene to 100%.
Formulation example 17:11% oxadiazon-dextro trans-chlorpropynyl pyrethroid microemulsion
The composition comprises 10% of bendiocarb, 1% of dextro trans-chlorpropynyl, 10% of styrylphenol polyoxyethylene ether, 10% of dimethyl succinate, 15% of deionized water and 100% of N-methylpyrrolidone.
Formulation example 18:2% oxadiazon-dextro trans-chlorpropynyl pyrethroid soluble liquid
1% of bendiocarb, 1% of dextro trans-chlorpropynyl, 3% of calcium alkyl benzene sulfonate, 6% of styrylphenol polyoxyethylene ether, 6% of propylene carbonate, 6% of piperonyl butoxide, 8% of ethanol and 100% of N-methylpyrrolidone.
Formulation example 19:16% oxadiazon-sevoflurane pyrethrin emulsifiable concentrate
14% of benflumetofen, 2% of tefluthrin, 6% of calcium alkyl benzene sulfonate, 4% of benzyl dimethyl phenol polyoxyethylene ether, 10% of phenyl phenol polyoxyethylene ether phosphate, 10% of dimethyl succinate and 100% of dodecylbenzene.
Formulation example 20:11% benflumetofen-sevoflurane pyrethrin microemulsion
10% of benflumetofen, 1% of tefluthrin, 5% of alkylaryl polyoxyethylene polyoxypropylene ether, 604% of span, 8% of span 802%, 8% of dimethyl 2-methylglutarate, 25% of deionized water, 5% of propanol and 100% of butanol.
Formulation example 21:20% oxadiazon-sevoflurane pyrethrin soluble liquid
15% of benflumetofen, 5% of tefluthrin, 3% of calcium alkyl benzene sulfonate, 5% of styrylphenol polyoxyethylene ether, 12% of N, N-dimethylpropionamide, 4% of piperonyl butoxide, 5% of ethanol and 100% of N-methylpyrrolidone.
Formulation example 22:7% oxadiazon-allethrin emulsifiable concentrate
6% of bendiocarb, 1% of allethrin, 4% of calcium alkyl benzene sulfonate, 4% of benzyl dimethyl phenol polyoxyethylene ether, 3% of phenyl phenol polyoxyethylene ether phosphate, 8% of dimethyl succinate and the balance of dodecylbenzene to 100%.
Formulation example 23:10% oxacarb-allethrin microemulsion
8% of bendiocarb, 2% of allethrin, 8% of fatty alcohol-polyoxyethylene ether, 2% of ethylene oxide-propylene oxide block copolymer, 5% of propylene carbonate, 20% of deionized water, 5% of dodecylbenzene, 3% of isopropanol and 100% of trimethylbenzene.
Formulation example 24:9% oxacarb-allethrin soluble liquid
8% of benflumetofen, 1% of allethrin, 6% of calcium alkyl benzene sulfonate, 12% of styrylphenol polyoxyethylene ether, 12% of N, N-dimethyl propionamide, 4% of piperonyl butoxide, 5% of ethanol and the balance of dimethyl sulfoxide to 100%.
Application example one: co-toxicity coefficient of oxacarb and pyrethroid to culex light color
Test object: culex light color (laboratory raising)
The test method comprises the following steps: pesticide first part with reference to the in-house bioassay test criteria: touch-killing activity test, the activity determination test is carried out on culex light color by adopting a drop method NY/T1154.1-2006.
Data statistics: and evaluating the activity of the compound culex pallidum on the culex pallidum by adopting a co-toxicity coefficient method. Then calculating LD of each medicine by DPS statistical software 50 And calculating the toxicity index and co-toxicity coefficient of the medicament according to the grand cloud Pei method. A co-toxicity coefficient greater than 120 indicates a synergistic effect, a co-toxicity coefficient between 80 and 120 indicates an additive effect, and a co-toxicity coefficient less than 80 indicates an antagonistic effect. The measurement results are shown in the following table:
TABLE 1 determination of the co-toxicity coefficient of oxacarb and tetrafluoromethyl ether pyrethroid (for culex light color)
Figure BDA0003442015390000061
As shown in Table 1, when the compounding ratio of the oxadiazon and the tetrafluoro methyl ether pyrethrin is 9:1-3:1, the co-toxicity coefficients of the oxadiazon and the tetrafluoro methyl ether pyrethrin against culex light-colored culex are all larger than 120, and the synergistic effect is achieved.
TABLE 2 determination of the co-toxicity coefficient of oxacarb and bifenthrin (against culex light color)
Figure BDA0003442015390000071
As shown in Table 2, when the compounding ratio of the oxadiazon and the chlorofluoroether is 8:1-2:1, the co-toxicity coefficients of the oxadiazon and the chlorofluoroether against culex light-colored culex are all greater than 120, and the synergistic effect is achieved.
TABLE 3 determination of the co-toxicity coefficient of oxacarb and bifenthrin (against culex light color)
Figure BDA0003442015390000072
As shown in Table 3, when the compounding ratio of the oxadiazon and the bifenthrin is 9:1-1:1, the co-toxicity coefficients of the oxamyl and the bifenthrin against culex light-colored mosquitoes are all larger than 120, and the synergistic effect is achieved.
TABLE 4 optimal co-toxicity coefficient of oxacarb and other pyrethroids (against culex light color)
Figure BDA0003442015390000081
As can be seen from Table 4, the optimal ratio of the oxadiazon to other pyrethroids is within the range of 7:1-3:1, and particularly the toxicity coefficient of the methotrexate, the transfluthrin, the tefluthrin, the dextro-trans-permethrin, the tefluthrin and the allethrin is more than 120, and the synergism is obvious.
Application example two: indoor space spraying pesticide effect test for preventing and controlling mosquitoes and flies
Test target: female adults which are not bloodsucking after the light culex and the eclosion are on the 3 rd to the 5 th days;
housefly, adult on 3 rd to 4 th days after emergence, male and female are half;
the test method comprises the following steps: referring to GB/T13917.10-2009, a site-cage hanging method is simulated;
control 1:7% oxadiazon emulsifiable concentrate
7% of bendiocarb, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenylphenol polyoxyethylene ether phosphate, 10% of propylene carbonate and the balance of dodecylbenzene to 100%.
Control 2:7% tetrafluoromethyl ether pyrethrin emulsifiable concentrate
7% of tetrafluoromethyl ether pyrethrin, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenyl phenol polyoxyethylene ether phosphate, 10% of propylene carbonate and the balance of dodecylbenzene to 100%.
Control 3:13% oxadiazon-tetrafluoromethyl ether pyrethrin emulsifiable concentrate
12% of bendiocarb, 1% of tetrafluoromethyl ether pyrethrin, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenyl phenol polyoxyethylene ether phosphate, 10% of propylene carbonate and the balance of dodecylbenzene to 100%.
Control 4:6% oxadiazon emulsifiable concentrate
6% of bendiocarb, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenylphenol polyoxyethylene ether phosphate, 15% of dimethyl 2-methylglutarate and 100% of dodecylbenzene.
Control 5:6% bifenthrin emulsifiable concentrate
6% of bifenthrin, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenyl phenol polyoxyethylene ether phosphate, 15% of dimethyl 2-methylglutarate and 100% of dodecylbenzene.
Control 6:11% oxadiazon and bifenthrin emulsifiable concentrate
10% of benflumetofen, 1% of bifenthrin, 3% of calcium alkyl benzene sulfonate, 4% of castor oil polyoxyethylene ether, 2% of phenylphenol polyoxyethylene ether phosphate, 15% of dimethyl 2-methylglutarate and 100% of dodecylbenzene.
Control 7:10.5% allyl permethrin emulsion (commercially available)
Control 8:21% Xin Liu high chlorofluoro emulsifiable concentrate (commercially available)
Test treatment: the preparation examples 1 and 4 and the control samples 1 to 8 are diluted to 200mg/L according to the total concentration of the active ingredients;
test results:
table 5 part of examples of formulations spatial spray efficacy test against mosquitoes and flies
Figure BDA0003442015390000091
Figure BDA0003442015390000101
As can be seen from table 5, the combination of the oxacarb and the pyrethroid has obvious synergism on knockdown and lethality of mosquitoes and flies, and compared with commercial products, the invention has higher knockdown and lethality for mosquitoes and flies, wherein the synergism is more obvious when the weight ratio of the oxacarb to the pyrethroid is within the preferred range.
Application example three: test of efficacy of space spraying sustained release agent
Test target: female adults which are not bloodsucking after the light culex and the eclosion are on the 3 rd to the 5 th days;
the test method comprises the following steps: referring to GB/T13917.10-2009, a site-cage hanging method is simulated;
control 9:8% oxadiazon-tetrafluoromethyl ether pyrethrin microemulsion
6% of bendiocarb, 2% of transfluthrin, 6% of styrene polyoxyethylene ether ammonium sulfate, 6% of alkyl diphenyl ether disulfonate magnesium, 10% of deionized water, 10% of dodecylbenzene and 100g of trimethylbenzene.
Control 10:9% oxacarb-bifenthrin microemulsion
8% of benflumetofen, 1% of bifenthrin, 8% of triethanolamine salt, 3% of benzyl dimethyl phenol polyoxyethylene ether, 15% of ethylene glycol, 30% of deionized water and the balance of dodecylbenzene to 100%.
Control 11:10% benflumetofen microemulsion
9% of benflumetofen, 1% of bifenthrin, 5% of benzyl dimethyl phenol polyoxyethylene ether, 10% of phenethyl phenol formaldehyde resin polyoxyethylene ether, 15% of deionized water, 5% of dibutyl phthalate and 100% of trimethylbenzene.
Test treatment: the preparation examples and the control samples are diluted to 200mg/L according to the total concentration of the active ingredients;
table 6 part of formulation examples efficacy test against mosquitoes and flies
Figure BDA0003442015390000102
Figure BDA0003442015390000111
As can be seen from Table 6, the pharmaceutical effects of formulation examples 2, 5 and 8 are significantly better than those of control samples 9, 10 and 11 (no sustained release agent was added to the formulation), but the knockdown and mortality against mosquitoes and flies are higher than those of the commercial products. The droplet diameter of the droplets ejected from the preparation examples 2, 5 and 8 was about 41 μm, while the droplet diameter of the droplets ejected from the control samples 9, 10 and 11 was about 64 μm, and the droplet diameter of the droplets was larger, and the droplet diameter of the droplets was smaller, so that the number of particles in the liquid medicine in the air was smaller, the sedimentation rate of the particles was faster, and the suspension time in the air was shorter, which resulted in poor efficacy.
In conclusion, the sanitary insecticidal composition containing the oxacarb and the pyrethroid has obvious synergy on sanitary pests after the oxacarb and the pyrethroid are compounded, and the compounded insecticide is used for space spraying, has high knockdown rate and high mortality rate, reduces the application times, reduces the labor cost and accords with the national policy direction of synergy and application reduction. Can be applied to hotels, schools, factories, families, farmers and public places for preventing and controlling mosquito, fly and other sanitary pests.
The foregoing examples are merely illustrative of the technical concept and technical features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the essence of the present invention should be included in the scope of the present invention.

Claims (10)

1. A sanitary insecticidal composition containing oxacarb and pyrethroid, which is characterized in that the effective components are the oxacarb and the pyrethroid, wherein: the content of the oxadiazon is 1-15%, the content of the pyrethroid is 1-5%, and the balance is auxiliary agent; the sanitary insecticidal composition is in the form of emulsifiable concentrate, microemulsion and soluble liquid.
2. A sanitary insecticidal composition according to claim 1 wherein the pyrethroid is selected from the group consisting of: any one of tefluthrin, bifenthrin, tefluthrin, bifenthrin, prallethrin, tefluthrin, and allethrin.
3. The sanitary insecticidal composition according to claim 1, wherein the weight ratio of the oxacarb to the pyrethroid is 15:1 to 1:1.
4. The sanitary insecticidal composition according to claim 1, wherein when the formulation of the sanitary insecticidal composition is emulsifiable concentrate, the auxiliary agent is an emulsifier, a space spraying slow release agent and a solvent, and the contents of the components are as follows: 1 to 15 percent of oxadiazon, 1 to 5 percent of pyrethroid, 5 to 20 percent of emulsifier, 1 to 30 percent of space spraying sustained release agent and the complement of solvent to 100 percent.
5. The sanitary insecticidal composition according to claim 1, wherein when the formulation of the sanitary insecticidal composition is a microemulsion, the auxiliary agent is an emulsifier, a space spraying slow release agent, a solvent and deionized water, and the contents of the components are as follows: 1 to 15 percent of oxadiazon, 1 to 5 percent of pyrethroid, 10 to 30 percent of emulsifier, 1 to 10 percent of space spraying sustained release agent, 1 to 30 percent of deionized water and the balance of solvent to 100 percent.
6. The sanitary insecticidal composition according to claim 1, wherein when the formulation of the sanitary insecticidal composition is a soluble liquid, the auxiliary agent is an emulsifier, a space spraying slow release agent and a solvent, and the contents of the components are as follows: 1 to 15 percent of oxadiazon, 1 to 5 percent of pyrethroid, 5 to 20 percent of emulsifier, 1 to 30 percent of space spraying sustained release agent and the complement of solvent to 100 percent.
7. A sanitary insecticidal composition according to any one of claims 4, 5 and 6 wherein said space spraying sustained release agent is selected from the group consisting of: and a mixture of two or more of dimethyl 2-methylglutarate, dimethyl succinate, N-dimethylpropionamide and propylene carbonate mixed in any proportion.
8. Use of a sanitary insecticidal composition according to claim 1 for controlling sanitary pests.
9. The use according to claim 8, wherein said hygienic insect pest is culex pallidum, culex tiredness, culex trichinensis, aedes albopictus, aedes aegypti, anopheles sinensis, midge, house fly, chrysomyia megacephala, lucilia sericata, copperus, liriomyza, xivium, primordium, german cockroach, periplaneta americana, bed bugs, flea, all-ditch hard ticks, chinese hard ticks, prairie hard ticks, small cattle ticks, leather mites and scabies.
10. The use according to claim 8, wherein the sanitary insect repellent composition is diluted 30-200 times with deionized water and sprayed in spaces of hotels, schools, factories, families and public places when controlling sanitary insect pests, so that the sanitary insect pests come into contact with the chemical agent when moving in the application space, thereby achieving the purpose of controlling sanitary insect pests.
CN202111635648.2A 2021-12-29 2021-12-29 Sanitary insecticidal composition containing oxacarb and pyrethroid Pending CN116406673A (en)

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