CN115997051A - 蛋白质支架 - Google Patents

蛋白质支架 Download PDF

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Publication number
CN115997051A
CN115997051A CN202180045296.7A CN202180045296A CN115997051A CN 115997051 A CN115997051 A CN 115997051A CN 202180045296 A CN202180045296 A CN 202180045296A CN 115997051 A CN115997051 A CN 115997051A
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China
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Pending
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CN202180045296.7A
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English (en)
Chinese (zh)
Inventor
菲利普·罗德利
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Nirvama Corp
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Nirvama Corp
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Publication of CN115997051A publication Critical patent/CN115997051A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202180045296.7A 2020-06-25 2021-05-27 蛋白质支架 Pending CN115997051A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/911,398 US11566346B2 (en) 2020-06-25 2020-06-25 Protein scaffold
US16/911,398 2020-06-25
PCT/NZ2021/050086 WO2021262012A2 (en) 2020-06-25 2021-05-27 Protein scaffold

Publications (1)

Publication Number Publication Date
CN115997051A true CN115997051A (zh) 2023-04-21

Family

ID=79032483

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180045296.7A Pending CN115997051A (zh) 2020-06-25 2021-05-27 蛋白质支架

Country Status (5)

Country Link
US (2) US11566346B2 (https=)
EP (1) EP4172389A4 (https=)
JP (1) JP7799325B2 (https=)
CN (1) CN115997051A (https=)
WO (1) WO2021262012A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024118635A2 (en) * 2022-11-28 2024-06-06 Nectagen, Inc. Thermostable binding scaffolds
WO2025096668A1 (en) * 2023-10-30 2025-05-08 The Board Of Trustees Of The Leland Stanford Junior University System and compositions comprising mhc scaffold and methods of identifying antigens using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009058379A2 (en) * 2007-10-31 2009-05-07 Medimmune, Llc Protein scaffolds
CN110725009A (zh) * 2011-09-27 2020-01-24 詹森生物科技公司 具有可供选择的结合表面的基于iii型纤连蛋白重复的蛋白质支架

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
ES2984405T3 (es) 2012-09-13 2024-10-29 Bristol Myers Squibb Co Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina
US10370776B2 (en) 2013-09-25 2019-08-06 Idea Orchard, Llc Antibody like protein
WO2020089235A1 (en) * 2018-10-29 2020-05-07 ETH Zürich Assay for screening of recombinant cells and microbes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009058379A2 (en) * 2007-10-31 2009-05-07 Medimmune, Llc Protein scaffolds
CN110725009A (zh) * 2011-09-27 2020-01-24 詹森生物科技公司 具有可供选择的结合表面的基于iii型纤连蛋白重复的蛋白质支架

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHO K H等: "An insight into the interaction mode between CheB and chemoreceptor from two crystal structures of CheB methylesterase catalytic domain", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 411, no. 1, 22 July 2011 (2011-07-22), pages 69 - 75 *

Also Published As

Publication number Publication date
JP7799325B2 (ja) 2026-01-15
US20230250557A1 (en) 2023-08-10
WO2021262012A2 (en) 2021-12-30
EP4172389A4 (en) 2024-10-30
EP4172389A2 (en) 2023-05-03
US20210403900A1 (en) 2021-12-30
WO2021262012A3 (en) 2022-02-03
JP2023541764A (ja) 2023-10-04
US12404606B2 (en) 2025-09-02
US11566346B2 (en) 2023-01-31

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