CN115989017A - 包含多元醇和聚氧乙烯-聚氧丙烯嵌段共聚物的凉爽个人护理组合物 - Google Patents
包含多元醇和聚氧乙烯-聚氧丙烯嵌段共聚物的凉爽个人护理组合物 Download PDFInfo
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- CN115989017A CN115989017A CN202180040148.6A CN202180040148A CN115989017A CN 115989017 A CN115989017 A CN 115989017A CN 202180040148 A CN202180040148 A CN 202180040148A CN 115989017 A CN115989017 A CN 115989017A
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Abstract
本发明涉及一种在局部施用根据本发明制备的组合物时以有效方式赋予皮肤凉爽效果的个人护理组合物。因此,本发明涉及一种组合物,其包含多元醇、感官调节剂和水与聚氧乙烯‑聚氧丙烯嵌段共聚物的协同组合。
Description
技术领域
本发明属于个人护理组合物的领域;具体地属于在皮肤上赋予凉爽感觉的皮肤有益组合物的领域。更具体地,本发明涉及一种个人护理组合物,其含有多元醇;聚氧乙烯-聚氧丙烯嵌段共聚物、嵌段共聚物增溶剂或它们的混合物;感官调节剂和水。
背景技术
作为人体上发现的最大器官,皮肤负责多种身体机能,包括感官接收、屏障保护和生理调节。然而,通常需要加快自然身体机能的发生速度。例如,在炎热、阳光充足和/或潮湿的气候中,理想的是涂抹一种产品,该产品能够在强烈阳光照射后使皮肤舒缓或凉爽,以帮助皮肤的温度调节和屏障修复。需要注意的是,凉爽个人护理组合物正变得越来越流行,特别是在诸如以上所述的那些的气候中和在日光浴是常态的文化中。当消费者尤其是医务人员佩戴个人防护设备时,凉爽个人护理组合物也是可取的。
传统上,个人护理组合物的凉爽效果可以通过包含显著水平的乙醇来实现,乙醇的挥发性允许在施用于皮肤时快速蒸发。虽然有效,但乙醇蒸发产生的凉爽效果持续相对短的时间段,并且可能会使皮肤干燥。此外,凉爽剂诸如薄荷醇、樟脑或离子化合物,即铵盐,通常用于局部个人护理组合物中,以在不物理冷却皮肤的情况下赋予皮肤凉爽感觉。然而,使用此类试剂通常会导致皮肤过敏。
因此,本发明人已经认识到需要开发一种个人护理组合物,该组合物能够提供凉爽效果,同时最小化潜在的缺点,诸如前面提到的那些缺点。因此,本发明涉及一种个人护理组合物,其具有多元醇;聚氧乙烯-聚氧丙烯嵌段共聚物、嵌段共聚物增溶剂或它们的混合物;感官调节剂和水。
附加信息
已经公开了用于制造凉爽个人护理组合物的努力。
美国专利号3,740,421涉及聚氧乙烯-聚氧乙烯丙烯水性凝胶。
美国专利号3,867,533公开了一种水性凝胶组合物,其包含使用聚氧乙烯-聚氧乙烯丙烯嵌段共聚物作为胶凝剂的水不溶性有机成分。
美国专利号4,407,788涉及一种在树脂聚(环氧乙烷)存在下与硅质抛光材料组合的含有液体保湿剂媒介物的洁牙剂。
美国专利申请公开US 2002/076423涉及用于日光浴后护理的凉爽化妆品或皮肤配制物,其包含壳聚糖、卵磷脂和挥发性物质。
美国专利申请公开US 2011/0224299公开了一种稳定的蜡组合物及其用途,其在施用于皮肤时可提供凉爽感觉。
PCT申请WO 2003/007909涉及一种凉爽化妆品或药物局部组合物,其特征在于包含棕榈酸甲酯。
上述附加信息均未描述以下物质的组合:聚(C2-C4烷氧基化物)嵌段共聚物、嵌段共聚物增溶剂或它们的混合物;多元醇;感官调节剂和,如本发明所要求的,该组合在局部施用于皮肤时产生凉爽效果。
发明内容
本发明人已经发现一种个人护理组合物,当局部施用于皮肤时,该组合物出乎意料地赋予凉爽效果,而不需要包括任选的传统凉爽剂。
因此,在第一方面,本发明涉及一种凉爽个人护理组合物,其包含与多元醇、感官调节剂和水组合的聚氧乙烯-聚氧丙烯嵌段共聚物、嵌段共聚物增溶剂或它们混合物。
在第二方面,本发明涉及一种处理需要处理的皮肤的方法,包括将所述凉爽个人护理组合物局部施用于需要处理的皮肤上的步骤。
在考虑具体实施方式和随后的实施例后,本发明的所有其他方面在将变得更加易懂。
为避免疑义,术语“包含”不意味着限制任何陈述的元素,而是包括具有主要或次要功能重要性的未指定元素。因此,所列出的步骤、元素或选项不必是详尽的。无论何时使用词语“包括”或“具有”,这些术语都意味着等效于如上定义的“包含”。所有范围都意味着包括所包含的所有那些范围。
如本文所用,术语“皮肤”包括面部、颈部、胸部、背部、手臂、腋窝、臂部、手部、腿部和头皮上的皮肤。如本文所用,皮肤有益剂是指包括这样的组分,该组分(a)在局部施用后改善面部或身体特征如皮肤特征,(b)有益于面部或身体特征如皮肤特征,或者(c):(a)和(b)二者。个人护理组合物是用于局部应用的组合物,并且包括乳剂、凝胶、霜剂、精华素、除臭剂、止汗剂、指甲护理剂和化妆品。在一个尤其优选的实施方案中,本发明的个人护理组合物是免洗型组合物。本文中关于组合物使用的术语“免洗型”是指施用于或擦在皮肤上并留在其上的组合物。“HLB”代表表面活性剂的亲水性-亲脂性平衡,用于测量表面活性剂亲水性或亲脂性的程度,并且在本领域广泛使用。如在此参考各成分所使用的术语“一种或多种衍生物”是指脂肪酸主链上的官能团取代基,包括羟基、烷氧基和C1-C4烷基取代基。如本文所用,术语“增溶剂”是指有助于使以其他方式不能溶解在介质中的成分溶解的成分。在短语“嵌段共聚物增溶剂”中使用“嵌段聚合物”意指为了阐明增溶剂的化学结构特征,而不是阐明增溶剂能够增溶的化合物。
除了实施例中的,或者另外明确指出的之外,本说明书中的表示成分的量的所有数字都应被理解为被词语“约”所修饰。除非另有说明,否则所有量均按组合物的总重量计。
具体实施方式
本发明的个人护理组合物中包含的多元醇化合物是多元醇型材料。典型的多元醇包括丙三醇(即甘油(glycerine)或甘油(glycerin))、丙二醇、双丙甘醇、聚丙二醇、聚乙二醇、山梨糖醇、羟丙基山梨糖醇、己二醇、1,3-丁二醇、异戊二醇、1,2,6-己三醇、乙氧基化丙三醇、丙氧基化丙三醇及它们的混合物。最优选的实施方案包括甘油、丁二醇、山梨糖醇或它们的混合物。按个人护理组合物的重量计,所用多元醇的量可以为0.1至7重量%,优选为0.25至5重量%,更优选为0.5至3重量%。
根据本发明的个人护理组合物的另一组分是共聚物表面活性剂,即聚(C2-C4烷氧基)嵌段共聚物。该聚合物包含至少一种氧化烯单元,该氧化烯单元选自式(C2H4O)n的氧乙烯链,其中n选自2至200、优选5至150的整数,式(C3H6O)n′的氧丙烯链,其中n′选自2至100、优选5至80的整数,和包含选自式(C2H4O)n的氧乙烯链和式(C3H6O)n′的氧丙烯链的链的无规和嵌段共聚物。聚氧乙烯-聚氧丙烯嵌段共聚物主链在一端以羟基末端终止,在另一端以氢化物末端终止。聚氧乙烯-聚氧丙烯嵌段共聚物的化学性质提供环氧乙烷基团的数量大于环氧丙烷基团的数量。在一个优选的实施方案中,环氧乙烷基团的数量与环氧丙烷基团的数量的比例为至少3:2。此外,适用于本发明的聚氧乙烯-聚氧丙烯嵌段共聚物是支链的。在另一个优选实施方案中,聚氧乙烯-聚氧丙烯嵌段共聚物含有支链环氧丙烷基团。嵌段共聚物的HLB值为12至29,优选为14至28,更优选为16至27。根据ASTM E222-17标准试验方法,嵌段共聚物的数均(Mn)分子量基于羟值为5000至20000,优选为7000至19000,最优选为8000至18000。在一个特别优选的实施方案中,泊洛沙姆407、泊洛沙姆338或它们的混合物用于本发明。泊洛沙姆407以F127商品名从供应商BASF商购获得,泊洛沙姆308以F108商品名从BASF商购获得。按个人护理组合物的重量计,聚氧乙烯-聚氧丙烯嵌段共聚物的总浓度可以为0.05至10重量%,优选为0.1至8重量%,最优选为0.2至5重量%。
使用嵌段共聚物增溶剂代替上述共聚物表面活性剂或与上述共聚物表面活性剂组合在本发明的范围内。在本发明的一个实施方案中,嵌段共聚物增溶剂材料是环氧乙烷-环氧丙烷聚合的聚乙二醇-聚丙二醇嵌段共聚物反应产物。嵌段共聚物增溶剂的HLB值为8至17,优选为9至15,更优选为10至13。根据ASTM E222-17标准试验方法,嵌段共聚物增溶剂的数均分子量基于羟值为5,000至20,000,优选为7,000至19,000,最优选为8,000至18,000。适用于本发明的嵌段共聚物增溶剂作为PEG/PPG-116/66共聚物由BASF以商品名L1220可商购获得。按个人护理组合物的重量计,嵌段共聚物增溶剂的总浓度可以为0.05至10重量%,优选为0.1至8重量%,最优选为0.2至5重量%。
本发明的凉爽个人护理组合物包含感官调节剂。感官调节剂的非限制性实例包括直链或支链C9-C22烷烃;直链或支链C5-C18脂肪酸酯;硅酮或它们的混合物。这种感官调节剂的衍生物也可以适合使用。感官调节剂可以以0.1至5%、优选0.2至3%、最优选0.3至2%的量存在于本发明中。
直链或支链变体的烷烃(C9-C22)可用于本发明。因此,包括烃在本发明的范围内。合适的烃可以包括矿物油和聚α-烯烃。优选的挥发性烃的实例包括聚癸烷诸如十一烷、十三烷、异癸烷、异十六烷和异十二烷以及C7-C8至C12-C15异链烷烃和它们的任何混合物。
脂肪酸酯(C5-C18)也适合用于本发明的个人护理组合物。说明性但非限制性实例包括衍生自酸前体的脂肪酸酯,所述酸前体有诸如新戊酸(例如新戊酸异癸酯)、异壬酸(例如,异壬酸乙基己酯、异壬酸异壬酯、异壬酸异癸酯和PEG-2二异壬酸酯)、2-乙基己酸(例如,PEG-2二乙基己酸酯、乙基己酸异癸酯)、癸酸(例如,癸酸己酯)、辛酸(例如,椰油醇-辛酸酯、辛酸丙基庚酯、辛酰-辛酸酯/癸酸酯)、异硬脂酸(例如,异硬脂酸甲基庚酯)、庚酸(例如,新戊二醇二庚酸酯)、肉豆蔻酸(例如,肉豆蔻酸异丙酯)、棕榈酸(例如,棕榈酸异丙酯)或它们的混合物。
使用来自称为甘油三酯的组的成分也在本发明的范围内。示例性但非限制性实例是葵花籽油、棉籽油、菜籽油、葡萄籽油、大豆油、蓖麻油、琉璃苣油、橄榄油、乳木果油、荷荷巴油以及它们的混合物。甘油单酯和甘油二酯也可以有用。这些类别的示例是单硬脂酸甘油酯和二硬脂酸甘油酯。按组合物的重量计,甘油三酯的量可以为0.01至10重量%,优选为0.1至8重量%。
适合使用的硅酮可分为挥发性和非挥发性种类。按组合物的重量计,量例如可以为0.01至25重量%,更优选为0.1至20%重量。如本文所用,术语“挥发性”是指在25℃下具有可测量蒸气压的那些材料。挥发性硅油优选选自含有3至9个、更优选4至5个硅原子的环状(环甲硅油)或线性聚二甲基硅氧烷。
可用于该组合物的非挥发性硅酮包括聚烷基硅氧烷、聚烷基芳基硅氧烷和聚醚硅氧烷共聚物。可用于本文的基本上非挥发性的聚烷基硅氧烷包括例如在25℃下粘度为约5×10-6至0.1m2/s的聚二甲基硅氧烷类。乳化和非乳化硅酮弹性体也适用于本发明的个人护理组合物中。
本发明的个人护理组合物还可以包括化妆品上可接受的媒介物。这种化妆品上可接受的媒介物可以是水性的或乳液。油性载体在水和乳化剂存在下会形成作为载体的乳液体系。优选地,组合物是水性的或乳液,尤其是水包油乳液。个人护理组合物通常为但不限于凝胶形式。本发明中使用的合适载体包括水、海水、玫瑰花水(例如大马士革玫瑰(RosaDamascena)花水)、茶(例如茶(Camellia Sinensis)叶水)、库拉索芦荟(AloeBarbadensis)(芦荟)叶汁、金缕梅(例如,北美金缕梅(Hamamelis Virginiana)提取物)、熏衣草水(例如,薰衣草(Lavendula Angustifolia)花水)、葡萄水(例如,葡萄(VitisVinifera)果水和葡萄果汁)。在一个特别优选的实施方案中,载体将是水,并且最终个人护理组合物是水性凝胶。化妆品上可接受的媒介物将通常形成个人护理组合物的70至98重量%,优选为75至97重量%,更优选为80至95重量%,并且可以在不存在其他化妆品辅料的情况下形成该组合物的余量。在一个优选的实施方案中,按化妆品上可接受的媒介物的重量计,载体是至少80重量%的水。
香料、增稠剂、皮肤有益剂、固定剂和研磨剂可任选地包含在本发明的个人护理组合物中。适用于本发明的皮肤有益剂意指包括但不限于遮光剂、着色剂、保湿剂、润肤剂、闭塞剂、植物提取物、光学剂、凉爽剂、亮肤剂、抗炎剂、抗痤疮剂、防晒剂、光稳定剂、表面活性剂、减皱剂、脱屑促进剂、去角质剂、它们的混合物等。当使用时,按个人护理组合物的总重量计,这些物质中的每一种可以为0.05至5重量%,优选为0.1至3重量%。
个人护理组合物可以任选地包含按个人护理组合物的重量计优选0.05至10重量%、更优选0.1至5重量%、甚至更优选0.25至4重量%的一种或多种增稠剂。有用的增稠剂包括多糖,该多糖包括淀粉、天然/合成树胶和纤维素类。合适的淀粉包括木薯淀粉、玉米淀粉、马铃薯淀粉、淀粉辛烯基琥珀酸铝和羟丙基淀粉磷酸钠。合适的树胶包括黄原胶、菌核、果胶、梧桐树胶、阿拉伯胶、琼脂、瓜尔胶、角叉菜胶、藻酸盐以及它们的组合。合适的纤维素包括羟丙基纤维素、羟丙基甲基纤维素、乙基纤维素和羧甲基纤维素钠。用作增稠剂的合成聚合物也适用,包括聚丙烯酰胺、卡波姆、牛磺酸酯共聚物和丙烯酸酯基聚合物。
脂肪酸也可以是掺入用于本发明的有用成分。术语“脂肪”是指10至30个碳原子的碳链长度。该类别的示例是壬酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、异硬脂酸、羟基硬脂酸、油酸、亚油酸、蓖麻油酸、花生酸、山嵛酸、芥酸及其组合。当使用时,组合物中存在0.01至5重量%的脂肪酸。
蜡和蜡酯也适用于本发明。这些蜡包括石油衍生的蜡(例如固体石蜡、矿脂、微晶蜡)、动物衍生的蜡或来自动物副产品的那些蜡(例如蜂蜡、鲸蜡、中国蜡、羊毛蜡、虫胶蜡)、植物衍生的蜡(例如三山嵛精蜡、巴西棕榈蜡、小烛树蜡、杨梅蜡、荷荷葩蜡、橙蜡、米糠蜡、向日葵蜡、蓖麻蜡、大豆蜡)、矿物蜡(例如,褐煤蜡、石蜡、地蜡)以及天然蜡的合成衍生物。如果使用,按组合物的重量计,蜡和蜡酯的量可以为0.01至10重量%,优选为0.1至8重量%。
乳化剂任选存在于本发明的个人护理组合物中。当所需化妆品上可接受的媒介物是乳液时,通常使用乳化剂。适合用于本发明的乳化剂具有2.5至17的HLB。当需要水连续乳液时使用的乳化剂的HLB值为8至17,优选为8.5至15,最优选为9至14,包括其中包含的所有范围。
当使用时,按组合物的重量计,乳化剂的总浓度可以为0.1至20重量%,优选为1至10重量%,最优选为1至8重量%,包括其中包含的所有范围。乳化剂可以选自阴离子、非离子、阳离子和两性表面活性剂。特别优选的非离子表面活性剂是具有以下的那些:与每摩尔疏水物约2至约100摩尔环氧乙烷或环氧丙烷缩合的C10-C20脂肪醇或脂肪酸疏水物;与2至20摩尔环氧烷缩合的C2-C10烷基酚;乙二醇的单-和二-脂肪酸酯;脂肪酸单甘油酯;脱水山梨糖醇单-和二-C8-C20脂肪酸;和聚氧乙烯脱水山梨糖醇以及它们的组合。烷基多糖苷和糖脂肪酰胺(例如甲基葡糖酰胺)也是合适的非离子乳化剂。
优选的阴离子乳化剂包括烷基醚硫酸盐和磺酸盐、烷基硫酸盐和磺酸钠、烷基苯磺酸盐、烷基和二烷基磺基琥珀酸盐、C8-C20酰基羟乙基磺酸盐、C8-C20酰基甲基羟乙基磺酸盐、C8-C20酰基甲基牛磺酸盐、C8-C20烷基醚磷酸盐、烷基醚羧酸盐或它们的组合。
可以使用的阳离子乳化剂包括例如棕榈酰胺丙基三甲基氯化铵、二硬脂基二甲基氯化铵、双酯季铵化合物(例如二硬脂酰乙基二甲基氯化铵)或它们的混合物。
有用的两性乳化剂包括椰油酰胺丙基甜菜碱、C12-C20三烷基甜菜碱、月桂酰两性乙酸钠和月桂基二两性乙酸钠或它们的混合物。
其他通常优选的乳化剂包括硬脂酸甘油酯、硬脂酸乙二醇酯、硬脂酰胺AMP、PEG-100硬脂酸酯、以及乳化/增稠添加剂,如丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物/角鲨烷及其混合物。
本发明的个人护理组合物可以包括维生素作为所需的皮肤有益剂,包括其衍生物诸如维生素烷基酯。示例性维生素是维生素A、维生素B2、维生素B3(烟酰胺)、维生素B5(泛醇)、维生素B6、维生素C、维生素E、维生素K、叶酸和生物素。也可以使用维生素的衍生物。例如,维生素C的衍生物包括抗坏血酸基四异棕榈酸酯、抗坏血酸磷酸酯镁和抗坏血酸葡糖苷。维生素E的衍生物包括生育酚乙酸酯、生育酚棕榈酸酯和生育酚亚油酸酯。维生素B3的衍生物包括烟酸。如果使用,当存在于根据本发明的个人护理组合物中时,维生素的总量可以为按个人护理组组合物的重量计0.001至10重量%,优选为0.01至5重量%,更优选为0.05至2.5重量%。
适合用于本发明的组合物的其他附加皮肤有益剂包括矿物质和皮肤营养物,诸如牛奶;镁、钙、铜、锌和其他金属组分;视黄酸及其衍生物(例如,顺式和反式);视黄醛;视黄醇;视黄酯,诸如乙酸视黄酯、棕榈酸视黄酯和丙酸视黄酯;α-羟基酸、β-羟基酸,例如水杨酸及其衍生物(例如5-辛酰水杨酸、庚氧基-4-水杨酸和4-甲氧基水杨酸);间苯二酚衍生物(特别是4-取代的间苯二醇衍生物,包括4-乙基间苯二酚、4-异丙基间苯二酚、4-己基间苯二酚、4-环戊基间苯二酚、4-环己基间苯二酚以及它们的酰化形式);白藜芦醇;糖类同分异构体;神经酰胺(例如神经酰胺1、神经酰胺3、神经酰胺3B和神经酰胺6)和假神经酰胺;尿囊素;季戊四醇四-二叔丁基羟基氢化肉桂酸酯;焦谷氨酸(PCA)盐衍生物,包括PCA锌和PCA钠;皮肤有益酸,诸如12-羟基硬脂酸、欧芹酸、共轭亚油酸、十八烷酸;透明质酸及其盐衍生物;它们的混合物等。虽然体系的凉爽能力已经足够,但也可以任选地添加凉爽剂,包括薄荷醇或其衍生物、樟脑或其衍生物以及离子化合物诸如铵盐,以增加皮肤上的凉爽感觉。还可以任选地添加乙醇用于皮肤的凉爽。此类皮肤有益剂在使用时共同构成个人护理组合物的0.001至12重量%。
多种选择的植物提取物可以任选地包括在本发明的个人护理组合物中。提取物可以溶解于分别为亲水性或疏水性的溶剂中所携带的水或油中。在一个优选的实施方案中,水或乙醇是提取溶剂。示例性实例包括提取自绿茶、蓍草、洋甘菊、甘草、芦荟、蜜桔、柳皮、紫花苜蓿、藻类、金缕梅、鼠尾草、百里香和迷迭香的那些,以及来源于沙棘、辣木、摩洛哥坚果树、鳄梨、金盏花、海藻和马鲁拉树的那些。可以任选使用其他赋予凉爽效果的精油,包括从薄荷、留兰香、薰衣草、桉树、檀香和香根草中提取的精油。可以使用大豆提取物,尤其是当需要包括视黄醇时。如果使用,则可以包括按个人护理组合物的总重量计0.001至12重量%的这些提取物。
传统的缓冲剂或pH调节剂也适用于包含在本发明的个人护理组合物中。这些包括常见的添加剂,诸如氢氧化钠、氢氧化钾、盐酸、柠檬酸、三乙醇胺、四羟丙基乙二胺和氨甲基丙醇。在一个优选的实施方案中,本发明的个人护理组合物的pH为3至8,更优选为3.25至7.75,最优选为4至7.5。本发明的个人护理组合物的粘度优选为约1,000至约120,000cps、最优选为约5,000至80,000cps,该粘度是在25℃和1s-1剪切速率的条件下用以Discovery名称可商购自供应商如T.A.Instruments的应变控制式平行板流变仪测量的。或者,也可以使用布氏粘度计(以20rpm的速度,主轴6,日光仪关闭,在25℃下持续30秒)测量粘度。
可以根据需要将防腐剂掺入本发明的组合物中以防止潜在有害微生物的生长。个人护理用品化学家熟悉合适的防腐剂,并经常选择它们以满足防腐剂测试和产品稳定性测试。防腐剂体系的选择应考虑到组合物的用途以及防腐剂与配制物中其他成分之间可能存在的不相容性。用于本发明的组合物的防腐剂的示例性实例包括但不限于碘代丙炔基丁基氨基甲酸酯(IPBC)、苯氧基乙醇、乙基己基甘油、对羟基苯甲酸甲酯、对羟基苯甲酸丙酯、咪唑烷基脲、去氢醋酸钠、苯甲酸钠、苯甲酸、对羟基苯甲酸的烷基酯、苯甲醇、对羟基苯乙酮、DMDM乙内酰脲衍生物、氯咪巴唑、丙酸盐以及各种季铵化合物。当使用时,防腐剂优选以按组合物的重量计0.01至2重量%的量使用,包括其中包含的所有范围。
本发明的个人护理组合物是一种适合于局部施用于人皮肤以提供皮肤益处的组合物,特别是免洗型产品。优选地,该术语包括凝胶,特别是保湿剂而不是化妆产品。最优选的是免洗型组合物。
许多类型的包装可用于储存和递送本发明的最终用途组合物。包装的选择取决于个人护理的最终用途和组合物本身的粘度。作为实例,用于皮肤的免洗型乳剂和霜剂通常使用在由合适的封闭物覆盖的分配端处具有开口的塑料容器。传统的封闭物包括带拉盖的铰链盖和螺旋盖。通常,贴片、瓶子、管、滚珠涂抹器、挤压容器或带盖的广口瓶是优选的。
个人护理组合物对皮肤的凉爽效果可以用IR温度计测量,诸如由FlukeCorporation市售的Fluke 62Mini IR温度计。在25℃和大气条件下,使用IR温度计测量小组成员前臂的初始皮肤温度并记录下来。使用传统的秤和称重船对样品进行称重,并测量0.5克的每个样品。将每个样品单独地沿着小组成员的前臂均匀分布30秒。IR温度计用于扫描所施用产品的总面积,并记录施用后皮肤温度的初始下降。随后以指定间隔(例如每30秒)进行温度测量,直到确定绝对最低温度。初始温度测量值和绝对最低温度测量值之间的差值表示为ΔTavg。将由根据本发明制备的样品组合物的施用获得的ΔTavg与锚定组合物的ΔTavg值进行比较。
现在将在以下具体的非限制性实施例的背景下描述本发明,以有助于更好地理解本发明。本领域普通技术人员将认识到,在不偏离本发明的教导的情况下,可以实施与所给出的实施例不同的本发明的变型。
实施例
所有样品均通过在中等剪切、约25℃至约75℃和大气压的条件下混合上述成分而制成。
将以下实施例中的所有样品与对照组合物(以下称为锚定组合物)进行比较,该锚定组合物由以具有凉爽作用的活性天然皮肤舒缓保湿霜(Active Naturals Skin Relief Moisturizing Cream with Cooling Action)市售。就本发明而言,本文所用的锚定组合物含有多元醇(即甘油)、感官调节剂(即二甲聚硅氧烷)和薄荷醇。
实施例1:根据本发明的全基本配方
成分 | 重量% |
水 | 余量 |
防腐剂 | 0.25 |
着色剂(0.0075%) | 0.38 |
甘油 | 1.0 |
遮光剂 | 0.50 |
泊洛沙姆 | 0.50 |
丙烯酸酯/丙烯酸C10-30烷基酯交联聚合物 | 0.50 |
矿脂 | 0.01 |
聚二甲基硅氧烷 | 0.50 |
环戊硅氧烷 | 0.50 |
维生素 | 0.01 |
防腐剂 | 0.60 |
pH调节剂(85%) | 0.88 |
香料 | 0.40 |
皮肤有益剂 | 1.0 |
薄荷醇 | 0.10 |
该全配方显示了对其进行了修改的以下实验中使用的基本配方。该全配方在下文中称为“FF”
实施例2:FF中薄荷醇的存在对凉爽效果的影响
结果表明,根据本发明制备的全配方出乎意料地导致皮肤表面的平均的温度下降(ΔTavg)比锚定样品大近2℃。还可以看出,含有或不含有薄荷醇的全配方将获得相同的结果,对平均的温度下降的影响可忽略不计。
实施例3:不同共聚物表面活性剂和/或嵌段共聚物增溶剂对凉爽效果的影响
是包含环氧乙烷和环氧丙烷单元或此类单元的反应产物的表面活性剂的商品名集合,其可从BASF商购获得。F127、F108和L1220的化学名称分别是泊洛沙姆407、泊洛沙姆338以及PEG/PPG-116/66共聚物。
结果表明,用其他共聚物表面活性剂或嵌段共聚物增溶剂代替共聚物表面活性活性剂可以在皮肤表面产生类似的ΔTavg值。
实施例4:不同感官调节剂水平对凉爽效果的影响
实施例4中的所有样品组合物是使用泊洛沙姆407制备的,并显示了改变感官调节剂含量水平(即环戊硅氧烷)对凉爽的影响。因此,本领域普通技术人员可以看到,感官调节剂的不断增加的水平会导致ΔTavg的类似下降。
实施例5:不同感官调节剂对凉爽效果的影响
实施例5中的所有样品组合物均使用0.5%的泊洛沙姆407制成。对根据实施例1中的组合物制备的全配方的修改均包含1.25%的甘油一致水平。出乎意料地,可以看出,与全配方相比,将特定的感官调节剂替换为另一种可以在皮肤的表面上产生类似或甚至更显著的平均的温度下降。
在该特定实施例中,所用的C12-17烷烃由Sonneborn以商品名商购获得,所用的C14-22烷烃由Sonneborn以商品名商购获得,所用的二甲聚硅氧烷5cSt由DowCorning以商品名XIAMETERTM PMX-200Silicone Fluid 5cSt商购获得。
实施例6:不同多元醇对凉爽效果的影响
使用0.5%的泊洛沙姆407和0.5%的环戊硅氧烷制备实施例6中的所有样品组合物。结果令人惊讶地表明,与全配方相比,使用不同的多元醇可以在皮肤表面产生相似或更大的平均的温度下降。在用戊二醇制备的样品中,尽管与FF相比,显示出ΔTavg的较低下降,但仍显示出在锚定组合物的ΔTavg上额外下降约1℃。
实施例7:多元醇和/或共聚物表面活性剂对凉爽效果的影响
实施例7中的所有样品组合物均使用泊洛沙姆407制成。通过改变甘油和共聚物表面活性剂的含量水平,本实施例的结果显示存在一些波动。值得注意的是,直到组合物中甘油的含量水平为至少10%时,才观察到这种波动是显著的。然而,即使在观察到有效性的这种下降之后,在所有含有10%甘油的样品中,所获得的凉爽效果仍然与锚定配方的凉爽效果相当。
Claims (12)
1.个人护理组合物,其包含:
(a)按所述个人护理组合物的重量计,0.5至3重量%的多元醇,所述多元醇包括甘油、丁二醇、山梨醇或它们的混合物;
(b)按所述个人护理组合物的重量计,0.2至5重量%的聚氧乙烯-聚氧丙烯嵌段共聚物、嵌段共聚物增溶剂(其是环氧乙烷-环氧丙烷聚合的聚乙二醇-聚丙二醇嵌段共聚物反应产物)、或它们的混合物;
(c)按所述个人护理组合物的重量计,0.3至2重量%的感官调节剂,
所述感官调节剂包括直链或支链C9-C21烷烃、C5-C18脂肪酸酯、硅酮或它们的混合物;及
(d)载体,其是水,其中所述个人护理组合物是水性凝胶,并且所述载体占所述个人护理组合物的80至98重量%。
2.根据权利要求1所述的个人护理组合物,其中所述聚氧乙烯-聚氧丙烯嵌段共聚物包含至少一种选自以下的氧化烯单元:式(C2H4O)n的氧乙烯链,其中n选自2至200的整数;至少式(C3H6O)n′的氧丙烯链,其中n′选自2至100的整数;和包含选自式(C2H4O)n的氧乙烯链和式(C3H6O)n′的氧丙烯链的链的无规和嵌段共聚物。
3.根据权利要求2所述的个人护理组合物,其中环氧乙烷单元的数量与环氧丙烷单元的数量的比例为至少3:2。
4.根据前述权利要求之一所述的个人护理组合物,其中所述聚氧乙烯-聚氧丙烯嵌段共聚物具有12至29的HLB值。
5.根据前述权利要求之一所述的个人护理组合物,其中所述聚氧乙烯-聚氧丙烯嵌段共聚物具有14至28的HLB值。
6.根据前述权利要求之一所述的个人护理组合物,其中所述嵌段共聚物增溶剂具有8至17的HLB值。
7.根据前述权利要求之一所述的个人护理组合物,其中所述嵌段共聚物增溶剂具有9至15的HLB值。
8.根据权利要求1所述的个人护理组合物,其中所述聚氧乙烯-聚氧丙烯嵌段共聚物或嵌段共聚物增溶剂具有5,000至20,000的数均分子量。
9.根据权利要求1所述的个人护理组合物,其中所述聚氧乙烯-聚氧丙烯嵌段共聚物或嵌段共聚物增溶剂具有7,000至19,000的数均分子量。
10.根据权利要求1所述的个人护理组合物,其中所述组合物包含0.05至10重量%的所述聚氧乙烯-聚氧丙烯嵌段共聚物、嵌段共聚物增溶剂或它们的混合物。
11.根据权利要求1所述的组合物用于在施用后使皮肤凉爽的用途。
12.根据权利要求1所述的个人护理组合物,其中所述组合物进一步包含薄荷醇、樟脑、乙醇、凉爽剂或它们的混合物。
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EP20178260 | 2020-06-04 | ||
EP20178260.4 | 2020-06-04 | ||
PCT/EP2021/064414 WO2021244983A1 (en) | 2020-06-04 | 2021-05-28 | Cooling personal care composition comprising a polyol and a polyoxyehtylene-polyoxypropylene block copolymer |
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EP (1) | EP4161483A1 (zh) |
JP (1) | JP2023527581A (zh) |
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CA (1) | CA3180382A1 (zh) |
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US3740421A (en) | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
US3867533A (en) | 1968-12-20 | 1975-02-18 | Basf Wyandotte Corp | Preparation of aqueous gel compositions containing a water-insoluble organic ingredient |
US4407788A (en) | 1981-09-08 | 1983-10-04 | Colgate-Palmolive Company | Dentifrice |
DE10036051A1 (de) | 2000-07-25 | 2002-02-07 | Beiersdorf Ag | Kosmetische oder dermatologische Formulierungen zur Pflege und Kühlung der Haut nach einem Sonnenbad |
DE10134603A1 (de) | 2001-07-17 | 2003-02-06 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit langanhaltender kühlender Wirkung |
US7659233B2 (en) * | 2004-10-25 | 2010-02-09 | Conopco, Inc. | Personal care compositions with silicones and dihydroxypropyl trialkyl ammonium salts |
AU2009205314A1 (en) * | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
US20110224299A1 (en) | 2009-09-03 | 2011-09-15 | Avon Products, Inc. | Stabilized Wax Composition and Uses Thereof |
EP2394703B1 (de) * | 2010-06-14 | 2015-12-23 | Symrise AG | Kühlmischungen mit verstärkter Kühlwirkung von 5-Methyl-2-(propan-2-yl)cyclohexyl-N-ethyloxamat |
WO2018236539A1 (en) * | 2017-06-20 | 2018-12-27 | Whitehill Life Sciences, Llc | SYNERGISTIC COMPOSITIONS AND METHODS FOR OBTAINING HOMEOSTASIS IN MAMMALIAN SYSTEMS |
CN109172387B (zh) * | 2018-10-24 | 2021-12-24 | 云南贝泰妮生物科技集团股份有限公司 | 一种改善雾化效果的喷雾制剂及其制备方法 |
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EP4161483A1 (en) | 2023-04-12 |
JP2023527581A (ja) | 2023-06-29 |
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