CN115974667B - Curcumin extraction method - Google Patents
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- CN115974667B CN115974667B CN202310113128.8A CN202310113128A CN115974667B CN 115974667 B CN115974667 B CN 115974667B CN 202310113128 A CN202310113128 A CN 202310113128A CN 115974667 B CN115974667 B CN 115974667B
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims abstract description 105
- 235000012754 curcumin Nutrition 0.000 title claims abstract description 48
- 229940109262 curcumin Drugs 0.000 title claims abstract description 48
- 239000004148 curcumin Substances 0.000 title claims abstract description 48
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 238000000605 extraction Methods 0.000 title claims abstract description 16
- 235000003373 curcuma longa Nutrition 0.000 claims abstract description 64
- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 63
- 235000013976 turmeric Nutrition 0.000 claims abstract description 63
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000843 powder Substances 0.000 claims abstract description 27
- 229930002875 chlorophyll Natural products 0.000 claims abstract description 23
- 235000019804 chlorophyll Nutrition 0.000 claims abstract description 23
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000005684 electric field Effects 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 14
- 239000000469 ethanolic extract Substances 0.000 claims abstract description 12
- 238000007710 freezing Methods 0.000 claims abstract description 7
- 230000005855 radiation Effects 0.000 claims description 17
- 238000002791 soaking Methods 0.000 claims description 16
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims description 11
- 229960002632 acarbose Drugs 0.000 claims description 11
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 10
- 241000407170 Curcuma Species 0.000 claims description 9
- 235000014375 Curcuma Nutrition 0.000 claims description 9
- 244000163122 Curcuma domestica Species 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 244000008991 Curcuma longa Species 0.000 abstract description 55
- 210000004027 cell Anatomy 0.000 abstract description 5
- 210000000170 cell membrane Anatomy 0.000 abstract description 4
- 210000002421 cell wall Anatomy 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 239000013078 crystal Substances 0.000 abstract description 2
- 230000008014 freezing Effects 0.000 abstract description 2
- 230000031700 light absorption Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000000341 volatile oil Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 16
- 238000002835 absorbance Methods 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000234299 Zingiberaceae Species 0.000 description 1
- 238000003811 acetone extraction Methods 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
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- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 230000003834 intracellular effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000000874 microwave-assisted extraction Methods 0.000 description 1
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- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
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- 230000000552 rheumatic effect Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
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- 238000002834 transmittance Methods 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of natural active product extraction, in particular to a curcumin extraction method. The turmeric slices are adopted as raw materials, pretreatment such as crushing, drying and the like is not needed, material loss caused by the crushing process is avoided, the turmeric slices are soaked in water, quick freezing is performed, water inside and outside turmeric cells is enabled to form ice crystals, turmeric cell membranes and cell walls are broken, substances in the turmeric cells are dissolved out, on one hand, the water and the volatile oil are volatilized and separated through microwave treatment, the curcumin is enabled to be rapidly and fully dissolved in an ethanol solution through bipolar square wave high-voltage pulse electric field treatment, so that high yield of the curcumin is ensured, an ethanol extract is concentrated to obtain paste, the curcumin can be protected by utilizing the light absorption property of chlorophyll through adding chlorophyll powder, the light stability of the curcumin is improved, and the curcumin is prevented from being decomposed due to exposure to light.
Description
Technical Field
The invention relates to the technical field of natural active product extraction, in particular to a curcumin extraction method.
Background
Turmeric is a dried rhizome of Curcuma longa belonging to the family Zingiberaceae, and is widely cultivated in Sichuan, fujian, guangdong, guangxi, yunnan, jiangxi, etc. in China, and has the effects of breaking blood, promoting qi, dredging meridians and relieving pain, and has warm nature, pungent and bitter taste, and spleen and liver meridians entering. Is mainly used for treating chest and hypochondrium stabbing pain, amenorrhea, rheumatic shoulder and arm pain, swelling and pain from injuries from falls, and the like. The main active ingredient of the modern research surface has a plurality of effects of resisting virus, resisting inflammation, resisting tumor, resisting oxidation, relieving drug toxicity and the like, and has wide application prospect.
In turmeric, the total curcumin components are main active ingredients, and have the characteristics of poor light stability, easy decomposition in alkaline water and high extraction and purification difficulty.
The curcumin extraction method in the prior art comprises ultraviolet spectrophotometry extraction technology, microwave extraction technology, enzyme extraction technology, and supercritical CO 2 The extraction technology, the acetone extraction technology and the like have the characteristic of poor light stability, namely the curcumin can generate bond fracture under the irradiation of natural lightDecomposition phenomenon although this property of curcumin can be prevented from decomposing by using a dark container, it is inevitable that curcumin is exposed to a light source during use, resulting in partial decomposition of curcumin, thereby reducing the utilization rate of curcumin.
Therefore, how to improve the extraction method of curcumin and improve the photostability of curcumin on the premise of ensuring excellent yield is a technical problem to be solved.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: how to improve the extraction method of curcumin, and improve the photostability of curcumin on the premise of ensuring excellent yield.
In order to solve the technical problems, the invention adopts the following technical scheme: a method for extracting curcumin, comprising the following parts:
step 1: soaking Curcuma rhizome slices in clear water at 20-30deg.C for 2-4 hr, and quick-freezing;
step 2: soaking the quick-frozen turmeric slices in water, and performing microwave radiation treatment, wherein the intensity of the microwave radiation is 2000-2500MHz, and the treatment time is 20-30min;
step 3: filtering turmeric after microwave radiation, removing filtrate, soaking turmeric in 50-60% ethanol solution, and then placing the turmeric in a bipolar square wave high-voltage pulse electric field, wherein the strength of the pulse electric field is 50-60kV/cm, the frequency is 1300-1400Hz, and the treatment time is 2-3 hours, so as to obtain turmeric slice ethanol extract;
step 4: filtering ethanol extract of Curcuma rhizome, concentrating to obtain paste;
step 5: adding chlorophyll powder into the paste, wherein the mass ratio of the paste to the chlorophyll powder is 6:3-2, stirring uniformly, and distilling at low temperature under reduced pressure to obtain solid powder, namely the product.
Wherein the mass ratio of turmeric to ethanol in the step 3 is 1:5-7.
The step 5 specifically includes: adding chlorophyll powder and acarbose into the paste, wherein the mass ratio of the paste to the acarbose to the chlorophyll powder is 6:1-2:2-3, stirring uniformly, and distilling at low temperature under reduced pressure to obtain solid powder, namely the product.
Wherein in the step 3, the temperature of the ethanol solution is 20-30 ℃.
In the step 3, the strength of the pulsed electric field is 55kV/cm, the frequency is 1350Hz, and the treatment time is 2.5h.
In the step 2, the intensity of the microwave radiation is 2300MHz, and the treatment time is 25min.
Wherein in the step 1, the thickness of the turmeric piece is 0.1-1mm.
The invention has the beneficial effects that: according to the curcumin extraction method, a turmeric slice is adopted as a raw material, pretreatment such as crushing, drying and the like is not needed, material loss caused by crushing is avoided, the turmeric slice is soaked in water, quick freezing is carried out, water inside and outside turmeric cells is enabled to form ice crystals, turmeric cell membranes and cell walls are broken, the curcumin is enabled to dissolve out in the turmeric cells, as curcumin is indissolvable in water, other components such as acetone are dissolved out, on one hand, the water and volatile oil are volatilized and separated, on the other hand, a large amount of heat is acquired by polar substances in the cells, the intracellular temperature is caused to rise, the cell membranes and the cell walls are further broken due to pressure generated by liquid water evaporation, the dissolution of the cell membranes and the cell walls is further accelerated, then, through filtration, substances dissolved in water such as acetone are separated along with filtrate, filter residues are soaked in ethanol solution, the curcumin is enabled to be rapidly and fully dissolved in the ethanol solution through bipolar square wave high-voltage pulse electric field treatment, the ethanol extract is concentrated to obtain paste, and chlorophyll powder is edible, so that the curcumin is safe, the chlorophyll is green in color, the chlorophyll is mixed with curcumin, and the light absorption property is utilized, and the curcumin is protected from light degradation under the condition that the curcumin is prevented from being exposed to light.
Furthermore, acarbose is added into the curcumin paste, so that the utilization rate of curcumin in organisms can be improved.
Detailed Description
In order to describe the technical contents, the achieved objects and effects of the present invention in detail, the following description will be made with reference to the embodiments.
Example 1
A method for extracting curcumin, comprising the following parts:
step 1: soaking the turmeric slices in clear water at 25 ℃ for 3 hours, and quick-freezing the soaked turmeric slices;
step 2: soaking the quick-frozen turmeric slices in water, and performing microwave radiation treatment, wherein the intensity of the microwave radiation is 2300MHz, and the treatment time is 25min;
step 3: filtering turmeric after microwave radiation, removing filtrate, soaking turmeric in 55% ethanol solution, and then placing the turmeric in a bipolar square wave high-voltage pulse electric field, wherein the strength of the pulse electric field is 55kV/cm, the frequency is 1350Hz, and the treatment time is 2.5 hours, so as to obtain turmeric slice ethanol extract, and the mass ratio of turmeric to ethanol is 1:6;
step 4: filtering ethanol extract of Curcuma rhizome, concentrating to obtain paste;
step 5: adding chlorophyll powder into the paste, adding the chlorophyll powder and acarbose into the paste, wherein the mass ratio of the paste, acarbose and chlorophyll powder is 6:1.5:2.5, stirring uniformly, and distilling under reduced pressure at low temperature to obtain solid powder, namely the product.
Example 2
A method for extracting curcumin, comprising the following parts:
step 1: soaking the turmeric slices in clear water at 20 ℃ for 2 hours, and quick-freezing the soaked turmeric slices;
step 2: soaking the quick-frozen turmeric slices in water, and performing microwave radiation treatment, wherein the intensity of the microwave radiation is 2000MHz, and the treatment time is 20min;
step 3: filtering turmeric after microwave radiation, removing filtrate, soaking turmeric in 50% ethanol solution, and then placing the turmeric in a bipolar square wave high-voltage pulse electric field, wherein the strength of the pulse electric field is 50kV/cm, the frequency is 1300Hz, the treatment time is 2 hours, and the turmeric slice ethanol extract is obtained, and the mass ratio of turmeric to ethanol is 1:5;
step 4: filtering ethanol extract of Curcuma rhizome, concentrating to obtain paste;
step 5: adding chlorophyll powder into the paste, adding the chlorophyll powder and acarbose into the paste, wherein the mass ratio of the paste, acarbose and chlorophyll powder is 6:1:3, stirring uniformly, and distilling under reduced pressure at low temperature to obtain solid powder, namely the product.
Example 3
A method for extracting curcumin, comprising the following parts:
step 1: soaking the turmeric slices in clear water at 30 ℃ for 4 hours, and quick-freezing the soaked turmeric slices;
step 2: soaking the quick-frozen turmeric slices in water, and performing microwave radiation treatment, wherein the intensity of the microwave radiation is 2400MHz, and the treatment time is 30min;
step 3: filtering turmeric after microwave radiation, removing filtrate, soaking turmeric in 60% ethanol solution, and then placing the turmeric in a bipolar square wave high-voltage pulse electric field, wherein the strength of the pulse electric field is 60kV/cm, the frequency is 1400Hz, the treatment time is 3 hours, and the turmeric slice ethanol extract is obtained, and the mass ratio of turmeric to ethanol is 1:7;
step 4: filtering ethanol extract of Curcuma rhizome, concentrating to obtain paste;
step 5: adding chlorophyll powder into the paste, adding the chlorophyll powder and acarbose into the paste, wherein the mass ratio of the paste, acarbose and chlorophyll powder is 6:2:2, stirring uniformly, and distilling under reduced pressure at low temperature to obtain solid powder, namely the product.
Comparative example 1
The method for extracting turmeric from turmeric described in example 1, except that step 2 was changed to: soaking the quick-frozen Curcuma rhizome slices in water, and heating at 80deg.C for 25min.
Comparative example 2
The method for extracting turmeric from turmeric described in example 1, except that step 1 was changed to: drying Curcuma rhizome, and grinding into powder.
Comparative example 3
The method for extracting turmeric from turmeric described in example 1 is different in that in step 3, bipolar square wave high voltage pulse electric field treatment is omitted.
Comparative example 4
The method for extracting turmeric from turmeric according to embodiment 1, except that in step 3, the pulsed electric field intensity is 20kV/cm, and the frequency is 600Hz.
Comparative example 5
The method for extracting turmeric from turmeric according to embodiment 1, except that in step 3, the pulsed electric field intensity is 80kV/cm, and the frequency is 1600Hz.
Comparative example 6
The method for extracting turmeric from turmeric described in example 1, except that chlorophyll was omitted in step 5.
Experimental example 1
The content determination method of curcumin comprises the following steps: the curcumin yield was calculated by measuring the transmittance of the curcumin resolution at 620nm, calculating the curcumin purity of the resolution by the ratio of the peak area of curcumin to the total area of the chromatogram in the resolution HPLC, and calculating the curcumin yield by the formula (curcumin content in resolution x volume of resolution) x 100%/turmeric mass.
The curcumin extraction effect was verified in each of the above examples and comparative examples, and the results are shown in table 1.
TABLE 1
| Group of | Purity (%) | Yield (%) |
| Example 1 | 97.1 | 6.93 |
| Example 2 | 96.3 | 6.75 |
| Example 3 | 96.8 | 6.37 |
| Comparative example 1 | 76.8 | 5.72 |
| Comparative example 2 | 93.5 | 5.48 |
| Comparative example 3 | 93.8 | 4.74 |
| Comparative example 4 | 95.8 | 5.72 |
| Comparative example 5 | 94.7 | 6.17 |
As can be seen from the results in Table 1, the products obtained in examples 1-3 were higher in both purity and yield than those obtained in comparative examples 1-5.
Experimental example 2
The products prepared in example 1 and comparative example 6 were dissolved in an equal amount of 55% ethanol solution, respectively, and the light treatment was continued, and the change in absorbance of the solution was measured every 5 days for 15 days. The results are shown in Table 2.
TABLE 2
| Group of | Absorbance at day 5 | Absorbance at day 10 | Absorbance at day 15 |
| Example 1 | 1.758 | 1.532 | 1.257 |
| Comparative example 6 | 1.387 | 0.756 | 0.178 |
As is clear from the results in Table 2, the decrease in absorbance of the aqueous curcumin solution of example 1 was not significant within 15 days, whereas the decrease in absorbance of the aqueous curcumin solution of comparative example 6 was significant within 15 days, demonstrating that the aqueous curcumin solution of example 1 had excellent photostability.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent modifications made by the teachings of the present invention, or direct or indirect application in the relevant art, are intended to be included within the scope of the present invention.
Claims (3)
1. The extraction method of curcumin is characterized by comprising the following steps:
step 1: soaking Curcuma rhizome slices in clear water at 20-30deg.C for 2-4 hr, and quick-freezing;
step 2: soaking the quick-frozen turmeric slices in water, and performing microwave radiation treatment, wherein the intensity of the microwave radiation is 2000-2500MHz, and the treatment time is 20-30min;
step 3: filtering turmeric after microwave radiation, removing filtrate, soaking turmeric in 50-60% ethanol solution, and then placing the turmeric in a bipolar square wave high-voltage pulse electric field, wherein the strength of the pulse electric field is 50-60kV/cm, the frequency is 1300-1400Hz, and the treatment time is 2-3 hours, so as to obtain turmeric slice ethanol extract;
step 4: filtering ethanol extract of Curcuma rhizome, concentrating to obtain paste;
step 5: adding chlorophyll powder into the paste, wherein the mass ratio of the paste to the chlorophyll powder is 6:3-2, uniformly stirring, and distilling at low temperature under reduced pressure to obtain solid powder, namely a product;
in the step 3, the mass ratio of turmeric to ethanol is 1:5-7;
the step 5 specifically comprises the following steps: adding chlorophyll powder and acarbose into the paste, wherein the mass ratio of the paste to the acarbose to the chlorophyll powder is 6:1-2:2-3, uniformly stirring, and distilling at low temperature under reduced pressure to obtain solid powder, namely a product;
in the step 3, the strength of the pulsed electric field is 55kV/cm, the frequency is 1350Hz, and the treatment time is 2.5 hours;
in the step 2, the intensity of microwave radiation is 2300MHz, and the treatment time is 25min.
2. The method for extracting curcumin according to claim 1, wherein in the step 3, the temperature of the ethanol solution is 20-30 ℃.
3. The method for extracting curcumin according to claim 1, wherein in the step 1, the thickness of the turmeric piece is 0.1-1mm.
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| CN202310113128.8A CN115974667B (en) | 2023-02-15 | 2023-02-15 | Curcumin extraction method |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103907877A (en) * | 2014-04-01 | 2014-07-09 | 江南大学 | Method for preparing ginger extract with aid of efficient and circulatory pulsed ultrasound wave |
| CN112979445A (en) * | 2019-12-17 | 2021-06-18 | 任钢 | Curcumin extraction method |
| CN113387785A (en) * | 2021-07-05 | 2021-09-14 | 中国科学院烟台海岸带研究所 | Method for extracting curcumin from turmeric with assistance of biological enzyme method combined with continuous flow ultrasonic |
| CN114105747A (en) * | 2021-12-17 | 2022-03-01 | 江南大学 | Method for improving curcumin extraction rate and purification effect |
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- 2023-02-15 CN CN202310113128.8A patent/CN115974667B/en active Active
- 2023-02-15 CN CN202410385972.0A patent/CN118324620A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103907877A (en) * | 2014-04-01 | 2014-07-09 | 江南大学 | Method for preparing ginger extract with aid of efficient and circulatory pulsed ultrasound wave |
| CN112979445A (en) * | 2019-12-17 | 2021-06-18 | 任钢 | Curcumin extraction method |
| CN113387785A (en) * | 2021-07-05 | 2021-09-14 | 中国科学院烟台海岸带研究所 | Method for extracting curcumin from turmeric with assistance of biological enzyme method combined with continuous flow ultrasonic |
| CN114105747A (en) * | 2021-12-17 | 2022-03-01 | 江南大学 | Method for improving curcumin extraction rate and purification effect |
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