CN115944705A - Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic heart failure and a preparation method thereof, and relates to the technical field of medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-50 parts of poria cocos, 5-20 parts of ginseng, 5-20 parts of monkshood (prepared), 5-20 parts of dried ginger and 5-20 parts of honey-fried licorice root. The raw materials of the composition are all pure natural medicinal materials, are simple and easy to obtain, and the five traditional Chinese medicines interact and cooperate with each other to have the effects of restoring yang and benefiting yin. A preparation method of a medicine for treating chronic heart failure comprises the following steps of weighing raw materials, adding 6-8 times of water of the total amount of the raw materials into monkshood (prepared), decocting for 0.5-1 hour, adding the rest medicinal materials, keeping slightly boiling for 1-1.5 hours, filtering by gauze, adding 5-6 times of water into medicine residues, continuously decocting for 1-1.5 hours, combining the two filtrates, concentrating and drying to obtain extracted medicine powder; mixing the extracted medicinal powder with pharmaceutically acceptable adjuvants, and making into various dosage forms; finally, the prepared dosage form is preserved for the patient to take. The invention mainly treats chronic heart failure and can also play a certain role in treating palpitation, asthma, insomnia, edema and other diseases.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating chronic heart failure and a preparation method thereof.
Background
The chronic heart failure is a common clinical disease and a frequently-occurring disease, along with the social development trend of aging of human mouth and urbanization, the Chinese cardiovascular diseases are on the increasing trend year by year, and the chronic heart failure is also on the increasing trend year by year. In 2014, the cardiovascular disease report in China indicates that cardiovascular disease death in China accounts for the first cause of total death of urban and rural residents, the number of rural areas is 44.8%, and the number of urban areas is 41.9%. Chronic heart failure affects the quality of life of patients to varying degrees, is one of the important causes of repeated hospitalizations of patients with cardiovascular diseases, and can lead to death. In clinic, cardiotonic, diuretic and vasodilator treatments are mostly adopted for patients with chronic heart failure, and medicines include beta-receptor blockers, diuretics, angiotensin II receptor antagonists and the like, but after the medicines are taken, liver and kidney functions of partial patients are seriously damaged, and even serious adverse reactions such as shock and heart failure occur.
The chronic heart failure belongs to the categories of asthma, edema, thoracic obstruction, palpitation and the like in the traditional Chinese medicine, the history of treating the heart failure by the traditional Chinese medicine is long, the pathogenesis of the chronic heart failure is based on essence, blood, yang and qi deficiency, and the stagnation of cold phlegm and blood stasis is the target. Clinically, the chronic heart failure patients are easy to cause water dampness and phlegm stagnation due to the failure of transforming qi into water by yang deficiency, and the symptoms of spleen and kidney yang deficiency and water flooding, hypodynamia, shortness of breath after activity, edema of both lower limbs and the like are often appeared. The traditional Chinese medicine has obvious effect of treating chronic heart failure by applying the principles of warming yang, promoting diuresis, benefiting yin, nourishing heart and the like, can maintain the functions of viscera, and has small adverse reaction. Therefore, it is of great clinical importance to develop a drug for treating or improving chronic heart failure, which can fundamentally treat or improve the symptoms.
Disclosure of Invention
The first purpose of the invention is to provide a traditional Chinese medicine composition for treating chronic heart failure; further aims at providing a preparation of the traditional Chinese medicine composition and a preparation method thereof.
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine composition for treating chronic heart failure comprises the following raw materials in parts by weight: 10-50 parts of poria cocos, 5-20 parts of ginseng, 5-20 parts of monkshood (prepared), 5-20 parts of dried ginger and 5-20 parts of honey-fried licorice root.
Preferably, the raw materials after proportioning can be directly subjected to impurity removal and then decocted in water for taking, and the active ingredients extracted by the conventional extraction technology in the field and pharmaceutically acceptable pharmaceutical excipients can be prepared into any method of various pharmaceutical dosage forms.
Preferably, the pharmaceutical adjuvant can be a sweetening agent, a preservative, a wetting agent, a lubricant, a disintegrating agent, a filling agent and a binding agent, or one or more of microcrystalline cellulose, sodium carboxymethyl starch, crospovidone, starch and lactose.
A preparation method of a medicine for treating chronic heart failure comprises the following steps:
the method comprises the following steps: weighing 20 parts of poria cocos, 10 parts of ginseng, 10 parts of prepared monkshood (prepared), 10 parts of dried ginger and 10 parts of honey-fried licorice root;
step two: adding 6-8 times of water into radix Aconiti lateralis (preparata), decocting for 0.5-1 hr, adding the rest materials, keeping boiling for 1-1.5 hr, filtering with gauze, adding 5-6 times of water into the residue, decocting for 1-1.5 hr, mixing the two filtrates, concentrating, drying, and grinding into powder to obtain medicinal powder;
step three: mixing the extracted medicinal powder with pharmaceutically acceptable adjuvants, and making into various dosage forms;
step four: the dosage form can be tablet, capsule, granule, honeyed pill, etc.;
step five: the prepared dosage form is preserved for administration by a patient.
Preferably, when the granules are prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, 0.3% of steviosin is added into the medicinal powder, and a 65% ethanol solution is used as a wetting agent, and the mixture is uniformly mixed, granulated, dried, granulated and packaged to obtain the granules.
Preferably, when the capsule is prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder is dextrin =1 to 2, 65% ethanol solution is used as a wetting agent, and the mixture is uniformly mixed, granulated, dried, granulated and encapsulated to obtain the hard capsule.
Preferably, when the composition is prepared into tablets, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder comprises 0.1-0.3 of lactose, microcrystalline cellulose = 1-1.5, 0.6-1% of magnesium stearate is added as a lubricant, 1-3% of crospovidone is added as a disintegrant, 65% of ethanol solution is used as a wetting agent, and the mixture is uniformly mixed, granulated, dried, granulated, tabletted and coated with a film to obtain the tablets.
Preferably, when the honeyed pill is prepared, the mixed medicinal powder is taken, crushed, sieved by a 80-mesh sieve, mixed with honey in a mass ratio of 1.
Compared with the prior art, the invention has the beneficial effects that: the medicine for treating chronic heart failure and the preparation method thereof, the invention mainly treats the chronic heart failure and can also play a certain role in treating palpitation, asthma, insomnia, edema and other diseases;
tuckahoe, poria cocos: sweet, bland and neutral in nature, entering heart, spleen and kidney meridians, and possessing the actions of invigorating spleen, inducing diuresis and excreting dampness, it is the key herb for inducing diuresis to alleviate edema. Poria has obvious diuretic effect, and can be used for improving water electrolyte disorder.
Ginseng: sweet, slightly bitter and warm in nature, entering lung, spleen and heart meridians, and can tonify primordial qi, tonify spleen and lung, and promote the production of body fluid. The ginsenoside in the ginseng can obviously improve the hypoxia tolerance of cardiac muscle.
Monkshood: pungent and sweet in property, with big heat and toxicity, it is the first important herb for rescuing collapse from collapse by restoring yang and also has the actions of tonifying fire and yang, dispelling cold and relieving pain. Radix Aconiti lateralis can inhibit the circulating renin-angiotensin-aldosterone system, and improve ventricular remodeling.
Dried ginger: pungent in property, heat entering spleen, stomach, kidney, heart and lung meridians, are the main drugs for warming middle energizer, and also have the actions of restoring yang, dredging collaterals, warming lung and resolving fluid retention. The Zingiberis rhizoma extract has effects of briefly increasing blood pressure, tranquilizing mind, and relieving pain.
Honey-fried licorice root: has sweet and mild nature and flavor, enters heart, lung, spleen and stomach meridians, and has the efficacies of tonifying spleen and lung, harmonizing drug property and the like.
Detailed Description
In the following, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and all other embodiments obtained by a person skilled in the art without making creative efforts shall fall within the protection scope of the present invention.
The invention provides a traditional Chinese medicine composition for treating chronic heart failure, which comprises the following raw materials in parts by weight: 10-50 parts of poria cocos, 5-20 parts of ginseng, 5-20 parts of monkshood (prepared), 5-20 parts of dried ginger and 5-20 parts of honey-fried licorice root. The poria cocos has the effects of tonifying spleen, promoting diuresis and excreting dampness, is an essential drug for inducing diuresis to alleviate edema, has an obvious diuretic effect, and can improve the phenomenon of water electrolyte disorder of an organism; the ginseng can greatly tonify primordial qi, tonify spleen and lung, promote the production of body fluid, and the ginsenoside in the ginseng can obviously improve the hypoxia tolerance of cardiac muscle; the monkshood is the first essential drug for restoring yang and rescuing collapse, has the effects of tonifying fire, supporting yang, dispelling cold and relieving pain, can inhibit a circulating renin-angiotensin-aldosterone system, and has an improvement effect on ventricular remodeling; zingiberis rhizoma is a principal drug for warming middle energizer, and has effects of restoring yang, dredging collaterals, warming lung, and eliminating retained fluid; the Zingiberis rhizoma extract has effects of briefly increasing pressure, tranquilizing, and relieving pain; radix Glycyrrhizae Preparata has effects of invigorating spleen and lung, and harmonizing drug property.
A preparation method of a medicine for treating chronic heart failure comprises the following steps:
the method comprises the following steps: weighing Poria, ginseng radix, radix Aconiti lateralis Preparata, zingiberis rhizoma, and radix Glycyrrhizae Preparata;
step two: adding 6-8 times of water into radix Aconiti lateralis (preparata), decocting for 0.5-1 hr, adding the rest materials, keeping boiling for 1-1.5 hr, filtering with gauze, adding 5-6 times of water into the residue, decocting for 1-1.5 hr, mixing the two filtrates, concentrating, drying, and grinding into powder to obtain medicinal powder;
step three: mixing the extracted medicinal powder with pharmaceutically acceptable adjuvants, and making into various dosage forms;
step four: the dosage form can be tablet, capsule, granule, honeyed pill, etc.; when the granules are prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder is 1.5-2 parts of dextrin =1, 0.3% of steviosin is added, 65% of ethanol solution is used as a wetting agent, and the granules are uniformly mixed, granulated, dried, granulated and packaged to obtain the granules; when the capsule is prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder is dextrin = 1; when the compound powder is prepared into tablets, the compound powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder comprises lactose, namely microcrystalline cellulose = 1-1.5, 0.1-0.3, 0.6-1% of magnesium stearate is added as a lubricant, 1-3% of crospovidone is added as a disintegrant, 65% of ethanol solution is used as a wetting agent, and the mixture is uniformly mixed, granulated, dried, granulated, tabletted and coated with a film coat to obtain the tablets; when the honey pills are prepared, the mixed medicinal powder is taken, crushed, sieved by a 80-mesh sieve, mixed with honey according to the mass ratio of 1;
step five: the prepared dosage form is preserved for administration by a patient.
Example 1 preparation of extract powder
Weighing 45 parts of poria cocos, 20 parts of ginseng, 20 parts of prepared aconite root (prepared), 20 parts of dried ginger and 20 parts of honey-fried licorice root. Adding 8 times of water into radix Aconiti lateralis (preparata), decocting for 0.5 hr, adding the rest materials, boiling for 1.5 hr, filtering with gauze, adding 6 times of water into the residue, decocting for 1 hr, mixing the two filtrates, concentrating, drying, and grinding into powder to obtain medicinal powder.
Example 2 preparation of extract powder
Weighing 25 parts of poria cocos, 15 parts of ginseng, 15 parts of prepared monkshood (prepared), 15 parts of dried ginger and 15 parts of honey-fried licorice root. Adding 6 times of water into radix Aconiti lateralis (preparata), decocting for 0.5 hr, adding the rest materials, boiling for 1.5 hr, filtering with gauze, adding 5 times of water into the residue, decocting for 1.5 hr, mixing the two filtrates, concentrating, drying, and grinding into powder to obtain the medicinal powder.
Example 3 preparation of extract powder
Weighing 20 parts of poria cocos, 10 parts of ginseng, 10 parts of prepared aconite root (prepared), 10 parts of dried ginger and 10 parts of honey-fried licorice root. Adding radix Aconiti lateralis (preparata) into 8 times of water, decocting for 1 hr, adding the rest materials, keeping boiling for 1 hr, filtering with gauze, adding 6 times of water into the residue, decocting for 1 hr, mixing the two filtrates, concentrating, drying, and grinding into powder to obtain the medicinal powder.
Example 4 granules
And (2) taking the medicinal powder obtained in the example 3, crushing, sieving by a 80-mesh sieve, adding 0.3% of stevioside and a 65% ethanol solution as a wetting agent into the medicinal powder, uniformly mixing, granulating, drying, grading and packaging to obtain granules.
Example 5 Capsule
And (3) taking the medicinal powder obtained in the example 3, crushing, sieving by a 80-mesh sieve, mixing the medicinal powder with dextrin = 1.5 and a 65% ethanol solution as a wetting agent, granulating, drying, grading and encapsulating to obtain the hard capsule.
Example 6 tablet
Taking the medicinal powder obtained in the example 3, crushing, sieving by a 80-mesh sieve, adding 0.6% of magnesium stearate as a lubricant, adding 1% of crospovidone as a disintegrant and 65% of ethanol solution as a wetting agent into the medicinal powder, uniformly mixing, granulating, drying, granulating, tabletting and coating by a film coating to obtain the tablet.
Example 7 honeyed pill
And (2) taking the medicinal powder obtained in the example 3, crushing, sieving with a 80-mesh sieve, mixing with honey according to the mass ratio of 1.
And (3) clinical observation:
1. case selection: the 60 patients of the group, aged 50-70 years, are all patients with chronic heart failure.
2. The treatment method comprises the following steps: the granules of the medicine for treating chronic heart failure prepared in example 4 are added on the basis of the conventional treatment of chronic heart failure, 1 dose is taken 1 time every day, 3 times every day, and the medicine is taken for 3 months.
3. Clinical symptoms: according to the standard formulated by the 2018 Chinese medical society 'China Heart failure diagnosis and treatment guide': (1) has a history of developing heart failure, such as coronary heart disease, hypertensive heart disease, pulmonary heart disease, dilated cardiomyopathy. (2) Clinical manifestations of heart failure: dyspnea, cough, expectoration and even hemoptysis after activity; fatigue; dizziness; palpitation; edema; abdominal distension; loss of appetite; pain in the liver region; oliguria and the like. (3) Signs of heart failure: enlargement of the heart; the heart rate is fast; a galloping horse law; p2 hyperfunction; moist rales on pulmonary diaphoresis; the jugular vein is angry; positive hepatic jugular reflux sign; enlargement of the liver; edema of both lower limbs; pleural/peritoneal effusion, etc. (4) Heart failure auxiliary examination: the chest film finds the signs of the lung congestion; the electrocardiogram can show the hypertrophy of the left ventricle and the right ventricle; echocardiography found systolic or diastolic dysfunction; elevated brain natriuretic peptide (brain natriuretic peptide). Meets any three items (1) and (4) and any two items (2) and (3), and excludes active myocarditis or pericarditis, acute coronary syndrome, severe valvular heart disease and alcoholic cardiomyopathy waiting, namely establishing clinical diagnosis.
4. Treatment criteria were: the treatment effect is judged according to the following standards by a NYHA heart function classification method: the improvement of the cardiac function by more than 2 grades is obvious effect; the effect is obtained when the heart function is improved by level 1 and is less than level 2; the patients with cardiac function improvement less than level 1 are not effective; deterioration of cardiac function at level 1 or above level 1 is deterioration.
5. Clinical results: of 60 patients, 29 cases (48.33%) were significantly effective, 26 cases (43.33%) were effective, 5 cases (8.33%) were ineffective, 0 case (0%) was worsened, and the total effective rate was 91.66%.
6. Typical cases
Case 1: wangzhi, male, 69 years old, with a history of coronary heart disease for 6 years, angina pectoris, shortness of breath after exercise, accompanied by hypertension. The medicine obtained in example 4 is continuously taken for 6 courses of treatment, and is taken 1 time respectively in the morning, at noon and at night; the heart color Doppler ultrasound prompts the improvement of left ventricular ejection fraction and the alleviation of breathlessness.
Case 2: li Shi, female, age 66, hypertension history 5 years, edema of both lower limbs, palpitation, decrease of appetite, hypodynamia, electrocardiogram, suggesting ventricular septum thickening. The medicine obtained in example 4 is continuously taken for 6 courses of treatment, and is taken 1 time respectively in the morning, at noon and evening, so that the arrhythmia of the electrocardiogram is reduced, and the symptoms are improved.
Case 3: zhou Zhi, male, 62 years old, coronary heart disease history 5 years, palpitation, shortness of breath after exercise, edema of both lower limbs, electrocardiogram suggest myocardial ischemia. The medicine obtained in example 4 is continuously taken for 6 courses of treatment, and the symptoms are obviously relieved after the medicine is taken for 1 time respectively in the morning, the noon and the evening.
Although the above embodiments have been described in detail for the purpose of illustration only and not for the purpose of limitation, it should be understood by those skilled in the art that the following descriptions are made by way of example only: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for treating chronic heart failure comprises the following raw materials in parts by weight: 10-50 parts of poria cocos, 5-20 parts of ginseng, 5-20 parts of monkshood (prepared), 5-20 parts of dried ginger and 5-20 parts of honey-fried licorice root.
2. The medicament for treating chronic heart failure according to claim 1, wherein: the raw materials after proportioning can be directly decocted in water after impurities are removed for taking, and the active ingredients extracted by the conventional extraction technology in the field and pharmaceutically acceptable pharmaceutic adjuvants can be prepared into various pharmaceutical dosage forms by any method.
3. A medicament for the treatment of chronic heart failure as claimed in claim 2, wherein: the pharmaceutical adjuvants can be sweetener, antiseptic, wetting agent, lubricant, disintegrating agent, filler and binder, or one or more of microcrystalline cellulose, sodium carboxymethyl starch, crospovidone, starch, and lactose.
4. A preparation method of a medicine for treating chronic heart failure is characterized by comprising the following steps: the method comprises the following steps:
the method comprises the following steps: weighing 20 parts of poria cocos, 10 parts of ginseng, 10 parts of prepared monkshood (prepared), 10 parts of dried ginger and 10 parts of honey-fried licorice root;
step two: adding 6-8 times of water into radix Aconiti lateralis (preparata), decocting for 0.5-1 hr, adding the rest materials, keeping boiling for 1-1.5 hr, filtering with gauze, adding 5-6 times of water into the residue, decocting for 1-1.5 hr, mixing the two filtrates, concentrating, drying, and grinding into powder to obtain medicinal powder;
step three: mixing the extracted medicinal powder with pharmaceutically acceptable adjuvants, and making into various dosage forms;
step four: the dosage form can be tablet, capsule, granule, honeyed pill, etc.;
step five: the prepared dosage form is preserved for administration by a patient.
5. The method for preparing a medicament for treating chronic heart failure according to claim 4, wherein: when the granules are prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder is 1.5-2 parts of dextrin =1, 0.3% of steviosin is added, 65% of ethanol solution is used as a wetting agent, and the granules are uniformly mixed, granulated, dried, granulated and packaged to obtain the granules.
6. The method for preparing a medicament for treating chronic heart failure according to claim 4, wherein: when the capsule is prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder is dextrin = 1.
7. The method for preparing a medicament for treating chronic heart failure according to claim 4, wherein: when the tablet is prepared, the mixed medicinal powder is taken, crushed and sieved by a 80-mesh sieve, the medicinal powder comprises 0.1-0.3 of lactose, microcrystalline cellulose = 1-1.5, 0.6% -1% of magnesium stearate is added as a lubricant, 1% -3% of crospovidone is added as a disintegrant, a 65% ethanol solution is used as a wetting agent, and the tablet is prepared by uniformly mixing, granulating, drying, granulating, tabletting and coating film coat.
8. The method for preparing a medicament for treating chronic heart failure according to claim 4, wherein: when the honey pills are prepared, the mixed medicinal powder is taken, crushed, sieved by a 80-mesh sieve, mixed with honey according to the mass ratio of 1.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888166A (en) * | 2015-05-20 | 2015-09-09 | 湖南中医药大学 | Pharmaceutical composition for warming yang and vitalizing debilitation, preparation containing pharmaceutical composition and application of traditional Chinese medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888166A (en) * | 2015-05-20 | 2015-09-09 | 湖南中医药大学 | Pharmaceutical composition for warming yang and vitalizing debilitation, preparation containing pharmaceutical composition and application of traditional Chinese medicine composition |
Non-Patent Citations (2)
| Title |
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| 夏裕;: "茯苓四逆汤治疗慢性心力衰竭疗效观察", 新中医, no. 08, pages 14 - 15 * |
| 温奕超;陈楠;王朝驹;张杜平;: "茯苓四逆汤治疗慢性肺源性心脏病心力衰竭", 中国实验方剂学杂志, no. 19, pages 266 - 267 * |
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