CN104888166A - Pharmaceutical composition for warming yang and vitalizing debilitation, preparation containing pharmaceutical composition and application of traditional Chinese medicine composition - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition, and particularly provides a pharmaceutical composition for warming yang and vitalizing debilitation, a preparation containing the pharmaceutical composition, and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components, by weight part: 500-900 of processed monkshood, 500-900 of dried ginger, 900-1300 of poria cocos, 300-600 of red ginseng, 900-1300 of dwarf lilyturf turber, 500-900 of Chinese magnoliavine, and 500-900 of licorice, preferably 710 of processed monkshood, 710 of dried ginger, 1065 of poria cocos, 426 of red ginseng, 1065 of dwarf lilyturf turber, 710 of Chinese magnoliavine, and 710 of licorice. The invention further provides the particle preparation containing the traditional Chinese medicine composition. The preparation has the efficacy of restoring yang to save the body from collapse and is suitable for the symptom of devitalizing yang qi of heart failure.

Description

A kind of warming YANG shakes the pharmaceutical composition that declines and containing its preparation and application

Technical field

The present invention relates to Chinese medicine composition, specifically, relate to a kind of warming YANG and to shake the pharmaceutical composition that declines and containing its preparation and application.

Background technology

Now on the market to the treatment prescription of heart failure and renal failure, it mostly is the product of simple warming YANG, namely uses Yin-nourishing drug, and its consumption is also less, does not meet negative and positive and provides the principle of helping each other mutually.And the agent that diuretic uses the drastic purgations such as Semen Lepidii (Semen Descurainiae) to relieve oedema or abdominal distension through diuresis or purgation often, hardly realize that drastic purgation will consume impairment of YANG gas and cloudy liquid further, curative effect is had a greatly reduced quality.

Clinical used Empirical formula is taught for The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine Chen Xinyu by the warming YANG side of declining that shakes.It, when treating heart failure and renal failure, has very significant curative effect.But its consumption also lacks unified standard at present, make it make preparation, therefore the present invention is intended to find warming YANG shakes the optimum amount proportioning of pharmaceutical composition of declining, and is made into granule.

Summary of the invention

In order to solve problems of the prior art, the object of this invention is to provide a kind of warming YANG and to shake the pharmaceutical composition that declines and containing its preparation and application.

In order to realize the object of the invention, first the present invention provides a kind of warming YANG to shake the pharmaceutical composition declined, and described pharmaceutical composition is grouped into by the one-tenth of following weight portion: Radix Aconiti Lateralis Preparata 500 ~ 900 parts, Rhizoma Zingiberis 500 ~ 900 parts, 900 ~ 1300 parts, Poria, Radix Ginseng Rubra 300 ~ 600 parts, Radix Ophiopogonis 900 ~ 1300 parts, Fructus Schisandrae Chinensis 500 ~ 900 parts and 500 ~ 900 parts, Radix Glycyrrhizae.

As preferably, described pharmaceutical composition is grouped into by the one-tenth of following weight portion: Radix Aconiti Lateralis Preparata 710 parts, Rhizoma Zingiberis 710 parts, 1065 parts, Poria, Radix Ginseng Rubra 426 parts, Radix Ophiopogonis 1065 parts, Fructus Schisandrae Chinensis 710 parts and 710 parts, Radix Glycyrrhizae.

Present invention also offers the preparation containing described pharmaceutical composition.

Further, described preparation is granule, and preparation method comprises the steps:

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20 (60 DEG C of surveys), vacuum drying, obtains dry extract, is ground into fine powder;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

Wherein, described step 2) in vacuum drying baking temperature be 60 ~ 80 DEG C, vacuum is-0.08 ~-0.09Mpa.

Present invention also offers the preparation method of previous formulations, described method comprises the steps:

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20 (60 DEG C of surveys), vacuum drying, obtains dry extract, is ground into fine powder;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

Wherein, described step 2) in vacuum drying baking temperature be 60 ~ 80 DEG C, vacuum is-0.08 ~-0.09Mpa.

Present invention also offers foregoing pharmaceutical compositions preparing warming YANG shakes the application declined in medicine.

Beneficial effect of the present invention is:

Heart failure, differential diagnosis in tcm belongs to flaccidity of the heart-yang, and our Radix Aconiti Lateralis Preparata used, Rhizoma Zingiberis, Radix Glycyrrhizae are Sini San structure, and the large heat of Radix Aconiti Lateralis Preparata great Xin, has effect of recuperating depleted YANG and rescuing the patient from collapse, is just accord with the syndrome that the yang-energy of heart failure is depressed." Radix Aconiti Lateralis Preparata is not warm without Rhizoma Zingiberis ", our Radix Aconiti Lateralis Preparata and Rhizoma Zingiberis are used in conjunction, and consumption is suitable, and its warming YANG effect is doubled.Heart failure often merges edema, therefore we use Poria, and large usage quantity, damp in body must be removed, and edema must be gone.And Poria is except dampness removing, also have effect of spleen invigorating, thus when relieving oedema or abdominal distension through diuresis or purgation also not impairment of YANG gas.The spleen being the foundation of acquired constitution, no matter heart-yang or kidney yang, all need spleen change the nourishing of angry blood; The spleen has the function to transport and transform nutrients, and the removing that water wets still needs the participation of spleen.Radix Ginseng Rubra in side, use same with Poria, plays the merit of replenishing QI to invigorate the spleen altogether, helps the transporting of spleen.Interdependence between yin and yang is use mutually, cloudy interior, sun keep also, the change of sun is raw, need be at all with the moon, therefore when warming YANG, still need YIN nourishing.Reuse Radix Ophiopogonis in side, just embody that " kind YANG invigorating person, must in treating YANG within YIN, then positive cloudy helping and change raw infinite; Kind nourishing YIN person, must with treating YIN within YANG, then YIN matched with sufficient YANG making living things fully vivid " meaning.Fang Zhongyong Fructus Schisandrae Chinensis, plays the effect of astringing QI, prevents the further dissipation of patient's yang-energy.

And preparation provided by the invention is in preparation process, prepares granule after the flour of Radix Ginseng Rubra is directly mixed into dry extract, save its effective ingredient.

Detailed description of the invention

Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.

Embodiment 1 warming YANG shakes the Chinese medicine preparation that declines

1, raw material

Radix Aconiti Lateralis Preparata 710 grams, Rhizoma Zingiberis 710 grams, 1065 grams, Poria, Radix Ginseng Rubra 426 grams, Radix Ophiopogonis 1065 grams, Fructus Schisandrae Chinensis 710 grams and 710 grams, Radix Glycyrrhizae.

2, preparation method

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20, vacuum drying, obtains dry extract, is ground into fine powder;

Vacuum drying baking temperature is 60 ~ 80 DEG C, and vacuum is-0.08 ~-0.09Mpa;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

Embodiment 2 warming YANG shakes the Chinese medicine preparation that declines

1, raw material

Radix Aconiti Lateralis Preparata 500 grams, Rhizoma Zingiberis 500 grams, 900 grams, Poria, Radix Ginseng Rubra 300 grams, Radix Ophiopogonis 900 grams, Fructus Schisandrae Chinensis 500 grams and 500 grams, Radix Glycyrrhizae.

2, preparation method

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20, vacuum drying, obtains dry extract, is ground into fine powder;

Vacuum drying baking temperature is 60 ~ 80 DEG C, and vacuum is-0.08 ~-0.09Mpa;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

Embodiment 3 warming YANG shakes the Chinese medicine preparation that declines

1, raw material

Radix Aconiti Lateralis Preparata 900 grams, Rhizoma Zingiberis 900 grams, 1300 grams, Poria, Radix Ginseng Rubra 600 grams, Radix Ophiopogonis 1300 grams, Fructus Schisandrae Chinensis 900 grams and 900 grams, Radix Glycyrrhizae.

2, preparation method

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20, vacuum drying, obtains dry extract, is ground into fine powder;

Vacuum drying baking temperature is 60 ~ 80 DEG C, and vacuum is-0.08 ~-0.09Mpa;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

Experimental example

This experimental example, to 90 chronic heart failures, is divided into 3 groups at random and carries out contrast experiment.Take embodiment 1-3 gained preparation respectively, every day twice, each 5g, continue after 4 weeks, with NYHA stage division for curative effect judging standard:

Effective: cardiac function reaches I level or cardiac function improves 2 grades;

Effective: cardiac function improves 1 grade, but less than 2 grades of persons;

Invalid: cardiac functional grading is unchanged;

Worsen: cardiac function worsens more than 1 grade or 1 grade.

Observe the curative effect, its result is as shown in table 1.

Rear three groups of cardiac function comparitive study treated by table 1

Note: embodiment 2 and embodiment 3 contrast with embodiment 1 respectively, its P<0.05

In sum, the effective percentage of pharmaceutical composition of the present invention is greater than 63%, and wherein, consumption part proportioning of embodiment 1 is optimal choice.

Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (8)

1. a warming YANG shakes the pharmaceutical composition declined, it is characterized in that, described pharmaceutical composition is grouped into by the one-tenth of following weight portion: Radix Aconiti Lateralis Preparata 500 ~ 900 parts, Rhizoma Zingiberis 500 ~ 900 parts, 900 ~ 1300 parts, Poria, Radix Ginseng Rubra 300 ~ 600 parts, Radix Ophiopogonis 900 ~ 1300 parts, Fructus Schisandrae Chinensis 500 ~ 900 parts and 500 ~ 900 parts, Radix Glycyrrhizae.

2. pharmaceutical composition according to claim 1, it is characterized in that, described pharmaceutical composition is grouped into by the one-tenth of following weight portion: Radix Aconiti Lateralis Preparata 710 parts, Rhizoma Zingiberis 710 parts, 1065 parts, Poria, Radix Ginseng Rubra 426 parts, Radix Ophiopogonis 1065 parts, Fructus Schisandrae Chinensis 710 parts and 710 parts, Radix Glycyrrhizae.

3. the preparation containing the pharmaceutical composition described in claim 1 or 2.

4. preparation according to claim 3, is characterized in that, described preparation is granule, and preparation method comprises the steps:

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20, vacuum drying, obtains dry extract, is ground into fine powder;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

5. preparation according to claim 4, is characterized in that, described step 2) in vacuum drying baking temperature be 60 ~ 80 DEG C, vacuum is-0.08 ~-0.09Mpa.

6. the preparation method of preparation described in any one of claim 3 ~ 5, is characterized in that, described method comprises the steps:

1) red ginseng powder is broken into fine powder, for subsequent use;

2) all the other Six-element Chinese medicines decoct with water secondary, and first time adds ten times amount soak by water 2 hours, and second time adds octuple water gaging and decocts 1.5 hours, collecting decoction, filter; Be evaporated to the extractum that relative density is about 1.20, vacuum drying, obtains dry extract, is ground into fine powder;

3) to step 2) add Radix Ginseng Rubra fine powder and dextrin in gained, mixing, with 95% ethanol soft material, makes granule, 60 ~ 80 DEG C of cold drying, granulate.

7. preparation method according to claim 6, is characterized in that, described step 2) in vacuum drying baking temperature be 60 ~ 80 DEG C, vacuum is-0.08 ~-0.09Mpa.

8. the pharmaceutical composition described in claim 1 or 2 to shake the application declined in medicine preparing warming YANG.