CN115943166A - 一种抗PD-L1/TGF-β融合蛋白 - Google Patents
一种抗PD-L1/TGF-β融合蛋白 Download PDFInfo
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Abstract
本发明涉及融合蛋白技术领域，具体而言，涉及抗PD‑L1/TGF‑β融合蛋白。所述融合蛋白包含抗PD‑L1抗体、肽接头和TGFβRⅡ胞外结构域，所述TGFβRⅡ胞外结构域通过肽接头连接至抗PD‑L1抗体重链的C末端。本发明的融合蛋白具有治疗PD‑L1和TGF‑β活性相关的疾病的潜力。
Description
PCT国内申请，说明书已公开。
Claims (18)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020104888046 | 2020-06-02 | ||
| CN202010488804.6A CN113754777A (zh) | 2020-06-02 | 2020-06-02 | 一种抗PD-L1/TGF-β融合蛋白 |
| PCT/CN2021/098012 WO2021244587A1 (zh) | 2020-06-02 | 2021-06-02 | 一种抗PD-L1/TGF-β融合蛋白 |
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| Publication Number | Publication Date |
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| CN115943166A true CN115943166A (zh) | 2023-04-07 |
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| CN202010488804.6A Pending CN113754777A (zh) | 2020-06-02 | 2020-06-02 | 一种抗PD-L1/TGF-β融合蛋白 |
| CN202180039999.9A Pending CN115943166A (zh) | 2020-06-02 | 2021-06-02 | 一种抗PD-L1/TGF-β融合蛋白 |
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| CN202010488804.6A Pending CN113754777A (zh) | 2020-06-02 | 2020-06-02 | 一种抗PD-L1/TGF-β融合蛋白 |
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| Country | Link |
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| CN (2) | CN113754777A (zh) |
| TW (1) | TW202146458A (zh) |
| WO (1) | WO2021244587A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20150056199A1 (en) * | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
| CN105461808B (zh) * | 2015-12-24 | 2019-03-19 | 长春金赛药业股份有限公司 | 单克隆抗体及其应用 |
| CA3061791A1 (en) * | 2017-05-12 | 2019-10-29 | Jiangsu Hengrui Medicine Co., Ltd. | Fusion protein containing tgf-.beta. receptor and medicinal uses thereof |
| UA127771C2 (uk) * | 2018-11-09 | 2023-12-27 | Джянгсу Хенгруй Медісін Ко., Лтд. | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЯКА МІСТИТЬ ЗЛИТИЙ ПРОТЕЇН РЕЦЕПТОРА TGF-<font face="Symbol">b, </font>ТА ЇЇ ЗАСТОСУВАННЯ |
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2020
- 2020-06-02 CN CN202010488804.6A patent/CN113754777A/zh active Pending
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2021
- 2021-06-02 TW TW110120000A patent/TW202146458A/zh unknown
- 2021-06-02 WO PCT/CN2021/098012 patent/WO2021244587A1/zh active Application Filing
- 2021-06-02 CN CN202180039999.9A patent/CN115943166A/zh active Pending
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| CN113754777A (zh) | 2021-12-07 |
| TW202146458A (zh) | 2021-12-16 |
| WO2021244587A1 (zh) | 2021-12-09 |
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