CN115919975A - Composition for promoting digestion and preparation method of beverage thereof - Google Patents
Composition for promoting digestion and preparation method of beverage thereof Download PDFInfo
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- CN115919975A CN115919975A CN202211696391.6A CN202211696391A CN115919975A CN 115919975 A CN115919975 A CN 115919975A CN 202211696391 A CN202211696391 A CN 202211696391A CN 115919975 A CN115919975 A CN 115919975A
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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Abstract
The invention provides a composition for aiding digestion and a preparation method of a drink thereof, and relates to the technical field of medicines, wherein the composition comprises radix pseudostellariae, kapok, rhizoma atractylodis macrocephalae, dried orange peel, hawthorn, malt, white hyacinth bean, citron, erythritol, sorbitol, honey and citric acid, the formula components are reasonably matched and are in synergistic compatibility, and the addition of the white hyacinth bean and the citron is beneficial to the synergism of the radix pseudostellariae and the rhizoma atractylodis macrocephalae for aiding gastrointestinal evacuation; the common bombax flower has the effects of promoting digestion and protecting the spleen and the stomach; the composition has the remarkable effects of regulating gastrointestinal movement, promoting gastrointestinal digestion and absorption, promoting gastrointestinal emptying, tonifying qi, invigorating spleen and promoting digestion; the composition is used for preparing beverage, has good flavor of traditional Chinese medicine, adopts the technology of concentrating and settling the water decoction, does not use preservative, and is suitable for the elderly, teenagers and other people who are easy to have bad intestines and stomach.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a composition for promoting digestion and a preparation method of a beverage thereof.
Background
Dyspepsia is a disease caused by gastric motility disorder, a common internal digestive system disease, and also includes gastroparesis and esophageal reflux disease, which have poor gastric motility. The dyspepsia is wide in morbidity population, the symptoms of the dyspepsia are mainly manifested by intermittent epigastric discomfort or pain, early satiety, abdominal distension, acid regurgitation, eructation and indigestion, the patient is unwilling to eat or eat less as much as possible due to discomfort such as chest distress, early satiety, abdominal distension and the like, and many patients are accompanied with mental symptoms such as insomnia, anxiety, depression, headache, inattention and the like. In some patients, borborygmus is in the abdomen, and increased air discharge, and even undigested food residues are often found in the excrement.
At present, the types of western medicines for treating dyspepsia are various, and the western medicines are known to have quick response and good curative effect, but have certain side effects and cannot be taken for a long time. Functional dyspepsia belongs to the categories of epigastric fullness, stomachache, epigastric upset and the like in the traditional Chinese medicine, the diseases of the functional dyspepsia are in the stomach, relate to organs such as the liver and the spleen, and are treated according to syndrome differentiation, and the treatment methods of strengthening the spleen and the stomach, soothing the liver and regulating qi, promoting digestion and removing food stagnation and the like are performed. In the treatment with the traditional Chinese medicine, the traditional Chinese medicine has small toxic and side effects, and has the effects of nourishing the stomach and tonifying the spleen after being taken for a long time, so that the traditional Chinese medicine is gradually accepted by more people. The researches on traditional Chinese medicine and traditional Chinese medicine for aiding digestion and improving gastrointestinal motility are increased year by year, and all the researches have unique points. According to the five internal organs corresponding to the five elements in traditional Chinese medicine, the treatment of dyspepsia is not only limited to stomach, but also relates to intestinal tract. Liver and spleen.
Chinese invention patent CN109758545A discloses a Chinese medicinal composition for strengthening spleen and stomach and aiding digestion, a preparation method and a medicament thereof, wherein the Chinese medicinal composition comprises white paeony root, radix scutellariae, cassia seed, glossy privet fruit, raw malt, medicated leaven, rhizoma anemarrhenae, bighead atractylodes rhizome, radix rehmanniae, golden cypress, poria cocos, medlar, radix bupleuri, astragalus mongholicus, liquorice, gentian, raw chicken's gizzard-membrane, chrysanthemum and hawthorn. The medicine prepared by adopting a water decoction mode can strengthen the spleen and stomach, dredge the liver and gallbladder, simultaneously regulate the urination and defecation, and has a good digestion-aiding effect. However, the above composition has many components and the preparation of the composition is troublesome. The Chinese invention patent CN110732007A provides a pharmaceutical composition for promoting digestion and a preparation method thereof, the composition comprises medicated leaven (stir-fried with bran), hawthorn, radish seed (stir-fried), tuckahoe, dried orange peel, patchouli, rhizoma pinelliae preparata and mangnolia officinalis (processed with ginger), and the composition can promote the propulsion of small intestine and the gastric emptying of mice.
The Chinese medicinal preparation is prepared from ginseng, poria cocos, bighead atractylodes rhizome, dried orange peel and liquorice, and is prepared from infant medicine evidence Zhi Jue (the formula of Xiao' er medicine evidence Zhi Jue) by the famous northern Song physicians Qian Yi. Wherein, the ginseng (the pseudostellaria root adopted in the research) is sweet and warm, strengthens the spleen and nourishes the stomach, supplements the middle-jiao and benefits qi, and leads the spleen and the stomach to generate qi and blood; bighead atractylodes rhizome, bitter in taste and warm in nature, has the effects of strengthening spleen and eliminating dampness, tonifying qi and generating blood, and is in the middle; tuckahoe, poria is sweet in taste and bland in flavor and capable of excreting dampness, strengthening the spleen and checking diarrhea, combines the effects of bighead atractylodes rhizome and promoting the spleen and stomach to transport and transform water and dampness, and uses the two herbs as mutual reinforcement to complement each other; the dried orange peel has the effects of regulating qi and eliminating dampness, has mild medicine property, can tonify qi and prevent congestion, is used for inducing diuresis and relieving swelling together with the tuckahoe, and is used for tonifying spleen and eliminating dampness, and promoting qi and harmonizing stomach together with the white atractylodes rhizome; the liquorice has the effects of tonifying middle-jiao and spleen, and tonifying qi, regulating qi and strengthening spleen.
The invention provides a composition comprising radix pseudostellariae, common bombax flower, largehead atractylodes rhizome, tangerine peel, hawthorn, malt, white hyacinth bean and citron, wherein auxiliary material components such as erythritol, sorbitol, honey, citric acid and the like are added on the basis of the composition, so that the composition has the remarkable effects of regulating gastrointestinal movement, promoting gastrointestinal digestion and absorption, promoting gastrointestinal emptying, tonifying qi, invigorating spleen and promoting digestion. The composition is applied to the preparation of drinks, has no additive, unique taste and flavor of traditional Chinese medicines, and is easily accepted by wide consumer groups, especially teenagers, the elderly and diabetics.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a preparation method of a digestion-aiding composition containing radix pseudostellariae and a drink thereof, wherein the traditional Chinese medicine components of the composition comprise radix pseudostellariae, kapok, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, hawthorn, malt, white hyacinth bean and citron which are cooperatively compatible, and the composition has the remarkable effects of regulating gastrointestinal movement, promoting gastrointestinal emptying, promoting digestion and absorption, tonifying qi and strengthening spleen; the composition can be used for preparing beverage, and has good taste and flavor.
In order to realize the purpose, the technical scheme adopted by the invention is as follows:
firstly, the invention provides a digestion-aiding composition, which comprises the following components in parts by weight: 1-6 parts of radix pseudostellariae, 1-6 parts of kapok, 1-6 parts of bighead atractylodes rhizome, 1-6 parts of dried orange peel, 4-10 parts of hawthorn, 4-10 parts of malt, 4-10 parts of white hyacinth bean, 3-10 parts of citron, 4-15 parts of erythritol, 3-10 parts of sorbitol, 2-10 parts of honey and 0.05-1 part of citric acid.
Preferably, the composition comprises the following components in parts by weight: 2-4 parts of radix pseudostellariae, 3-5 parts of common bombax flower, 2-4 parts of bighead atractylodes rhizome, 2-4 parts of dried orange peel, 5-7 parts of hawthorn, 6-8 parts of malt, 4-6 parts of white hyacinth bean, 4-6 parts of citron, 6-12 parts of erythritol, 4-8 parts of sorbitol, 4-8 parts of honey and 0.1-0.5 part of citric acid.
Further preferably, the composition comprises the following components in parts by weight: 3 parts of radix pseudostellariae, 4 parts of kapok, 3 parts of bighead atractylodes rhizome, 3 parts of dried orange peel, 6 parts of hawthorn, 7 parts of malt, 5 parts of white hyacinth bean, 5 parts of citron, 10 parts of erythritol, 6 parts of sorbitol, 5 parts of honey and 0.2 part of citric acid.
Furthermore, the present invention provides a method for preparing the above composition, comprising the steps of:
(1) Soaking radix Pseudostellariae, atractylodis rhizoma, pericarpium Citri Tangerinae, fructus Hordei Germinatus, semen lablab album, and fructus Citri in water, decocting, and filtering to obtain filtrate 1 and residue 1;
(2) Decocting flos Bombacis Malabarici with water, and filtering while hot to obtain filtrate 2 and residue 2
(3) Mixing the filter residue 1 and the filter residue 2 with the hawthorn, adding water, decocting, and filtering while hot to obtain a filtrate 3;
(4) Mixing the filtrate 1, the filtrate 2 and the filtrate 3, and centrifuging to recover a supernatant to obtain a total filtrate;
(5) Mixing the total filtrate with erythritol, sorbitol, mel, and citric acid to obtain beverage.
Preferably, in the step (1), the soaking is specifically carried out for 20-90min, wherein the weight ratio of the heterophylly falsestarwort root, the largehead atractylodes rhizome, the tangerine peel, the malt, the white hyacinth bean and the citron to the water is 1:2-12.
Preferably, in the step (1), the decoction is carried out for 0.5 to 2 hours after boiling with strong fire and then slightly boiling with soft fire.
More preferably, the decocting is carried out by boiling with strong fire, then boiling with soft fire for 1-1.5h; the decoction should always be carried out with water without any medicinal materials in the composition.
Preferably, in the step (1), before soaking, the Chinese medicinal components are cleaned and cut into small pieces.
Preferably, in the step (2), the decocting with water is as follows: the weight ratio of the common bombax flower to the water is 1:1-5, and the common bombax flower is decocted for 20-60min with soft fire.
Further preferably, the decocting with water comprises: the weight ratio of the common bombax flower to the water is 1:2-4, and the common bombax flower is decocted for 30-40min with soft fire.
Preferably, in the step (3), the decocting with water is carried out by adding 1-10 times of water into the mixed filter residue and the hawthorn, boiling with strong fire, and then boiling with soft fire for 0.5-2h.
Preferably, the water decoction is carried out by adding 4-6 times of water into the mixed filter residue and the hawthorn, boiling with strong fire, and then boiling with slow fire for 50-90min.
Preferably, in the step (4), the supernatant is recovered by centrifugation, specifically, the centrifugation is performed at low temperature of 2-6 ℃,6000-8000r/min, and 5-15min.
Preferably, in the step (5), fruit juice can be added to the beverage according to the requirement, and the preparation of the fruit juice specifically comprises the following steps: juicing fruit, filtering, centrifuging, and collecting supernatant to obtain fruit juice. Adding into the mixed beverage.
Further preferably, the volume ratio of the fruit juice to the beverage of step (5) is 0.05-0.2.
Further preferably, the fruit is selected from at least one of grapes, blueberries, mulberries, strawberries, apples, litchis and oranges.
Preferably, in the step (5), the medicine content of the beverage is 0.05-0.2g/mL; the content is the weight concentration of the total amount of radix Pseudostellariae, flos Bombacis Malabarici, atractylodis rhizoma, pericarpium Citri Tangerinae, fructus crataegi, fructus Hordei Germinatus, semen lablab album, and fructus Citri in unit beverage.
Finally, the invention provides a drink prepared by the preparation method, which has the functions of regulating gastrointestinal movement, promoting gastrointestinal digestion and absorption, promoting gastrointestinal emptying, and tonifying qi, invigorating spleen and promoting digestion.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention provides a composition, which creatively combines heterophylly falsestarwort root, common bombax flower, largehead atractylodes rhizome, tangerine peel, hawthorn, malt, white hyacinth bean and citron, and the components are formulated according to a certain weight part, have synergistic interaction and have obvious curative effects of regulating gastrointestinal movement, promoting gastrointestinal emptying, helping digestion, replenishing qi, invigorating spleen and promoting digestion.
2. The invention provides a composition with the effects of helping digestion, regulating gastrointestinal movement and promoting gastrointestinal emptying, and the composition has the effects of promoting gastrointestinal emptying, resolving dampness, regulating qi and strengthening spleen. The radix pseudostellariae is adopted to replace ginseng in the research, so that qi is supplemented without excessive internal heat, and the radix pseudostellariae health-care tea is more suitable for long-term use; kapok has the effects of protecting spleen and stomach and promoting diuresis; the hawthorn and malt neutralizing composition has good taste and flavor of traditional Chinese medicines.
3. The invention also provides a preparation method of the traditional Chinese medicine composition beverage for promoting gastrointestinal absorption, which adopts a water decoction concentration and sedimentation technology, and simultaneously reasonably matches erythritol and sorbitol, so that the traditional Chinese medicine composition beverage is suitable for being eaten by the elderly, teenagers and other people who are easy to have poor gastrointestinal functions; and has constipation preventing effect after long-term consumption.
Drawings
FIG. 1 is a graph showing the effects of inducing diuresis and excreting stool in mice of the blank group;
FIG. 2 is a graph showing the effects of inducing diuresis and excreting stool in mice of the model group of the present invention;
FIG. 3 is a graph showing the effects of inducing diuresis and excreting stool in mice according to example 1 of the present invention;
FIG. 4 is a graph showing the effects of inducing diuresis and excreting stool in mice according to example 2 of the present invention;
FIG. 5 is a graph showing the effects of inducing diuresis and excreting stool in mice in example 3 of the present invention.
Detailed Description
The following non-limiting examples will provide those of ordinary skill in the art with a more complete understanding of the present invention, but are not intended to limit the invention in any way. The following is merely an illustrative description of the scope of the invention claimed herein, and those skilled in the art can make various changes and modifications to the invention of the present application based on the disclosure, which should also fall within the scope of the invention claimed herein.
The invention will now be further illustrated by means of specific examples. The various chemicals used in the examples of the present invention were obtained by conventional commercial routes unless otherwise specified. The erythritol is purchased from Shanghai Michelin Biotechnology Limited and has the product number of SJ-E808834; the sorbitol is purchased from Shanghai Michelin Biotechnology, inc. under the product number D817607. Radix pseudostellariae: sweet, slightly bitter and mild in nature and taste. It is good for children's sweating due to deficiency, and is often combined with Bei Sha Shen, bai Dou and shan Yao to treat stomach weakness and poor appetite.
Kapok: is dried flower of bombax ceiba of bombax family, has sweet taste and cool property, and can be used for treating diarrhea, dysentery and hemorrhoid hemorrhage. Flos Bombacis Malabarici has effects of invigorating stomach, flavoring intestinal tract, and relieving diarrhea and chronic gastrointestinal abdominal distention. Common bombax flower and dried orange peel have the effects of tonifying spleen, clearing damp and nourishing stomach when eaten together.
White atractylodes rhizome: bitter, sweet and warm in nature. It enters spleen and stomach meridians. Is a deficiency tonifying medicine and is used for treating spleen deficiency, anorexia, abdominal distention and diarrhea. The bighead atractylodes rhizome has the functions of regulating spleen and stomach and preventing gastric ulcer, can be used for helping to improve the gastrointestinal dysfunction, regulating intestines and stomach and accelerating the digestion and absorption of food; after being taken, the health-care food can protect gastric mucosa, reduce food, stimulate the gastric mucosa, promote the secretion of gastric juice and accelerate the digestion and absorption of food.
Dried orange peel: picking mature fruits, peeling off peels, and drying in the sun or at a low temperature; bitter and pungent in flavor and warm in nature. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm. It is combined with shan Zha and Shen Qu for food stagnation, qi stagnation and abdominal distention and pain.
Hawthorn fruit: sour and sweet, slightly warm. Hawthorn contains various organic acids. After eating, the activity of pepsin can be improved, and the digestion of protein and fat can be promoted; the unique sour taste stimulates gastric mucosa to promote gastric secretion; the hawthorn has the functions of regulating the gastrointestinal motility, inhibiting spastic gastrointestinal smooth muscles and exciting relaxed smooth muscles. Is a good medicine for strengthening spleen, stimulating appetite, promoting digestion, removing food stagnation, promoting blood circulation and eliminating phlegm.
Malt: recorded in the original source of medicine, mai ya tonifies deficiency of spleen and stomach, widens intestines and stomach, smashes finely, fries to be yellow, and takes out the powder for use. The raw malt has the main effects of strengthening the spleen and stomach, soothing the liver and promoting the circulation of qi, and is mainly used for treating the symptoms of insufficient appetite due to spleen deficiency, milk insufficiency caused by stagnation of liver qi and the like; the roasted malt is produced by roasting raw malt, has the main effects of promoting digestion, promoting qi circulation and promoting lactation, and is mainly used for indigestion and female weaning.
White hyacinth bean: is dry and mature seed of hyacinth bean of Leguminosae, and has sweet and mild medicinal property and can enter spleen and stomach meridians. Recorded in Dian nan Ben Cao (materia Medica of Dian) for treating weakness of spleen and stomach, regurgitation, cold vomiting, chronic diarrhea, dyspepsia and abdominal mass.
Citron: is a dry mature fruit of Citrus medica of Rutaceae, has pungent, bitter, sour and warm properties, and enters liver, spleen and lung channels, and is especially suitable for patients with liver-spleen disharmony. The citron contains abundant volatile oil (such as citral and phellandrene), aromatic substances (such as abundant flavonoid ingredients) and tartaric acid, can promote secretion of various digestive juices such as saliva and gastric juice, and has the effects of eliminating stomach bacteria and relieving inflammation.
Erythritol: as a sugar, the molecular weight is very small, most of the sugar can be quickly absorbed in cerebellum, and the sugar can not be metabolized and decomposed and is discharged out of the body along with urine; erythritol has a lower average glycemic index and a lower average insulin index than xylitol, and therefore has less effect on blood glucose and is suitable for diabetic patients.
Sorbitol: as a food additive, the product can improve food moisturizing and thickening effects, and is a sweetener with sweetness comparable to that of glucose, which can be slowly absorbed and utilized in vivo, has little influence on blood sugar, and can be taken by diabetic patients.
Examples 1 to 3
The component formulas of the compositions of examples 1-3 are shown in Table 1 in parts by weight, and the preparation methods of the drink are consistent.
TABLE 1
In embodiments 1 to 3 of the present invention, a method for preparing a beverage includes the steps of:
(1) Cleaning radix Pseudostellariae, atractylodis rhizoma, pericarpium Citri Tangerinae, fructus Hordei Germinatus, semen lablab album and fructus Citri, cutting into small pieces, soaking in 3 times of water for 40min, boiling with strong fire, boiling with slow fire for 1 hr, and filtering under reduced pressure to obtain filtrate 1 and residue 1;
(2) Cleaning flos Bombacis Malabarici, soaking in 3 times of water, decocting with slow fire for 40min, and filtering under reduced pressure to obtain filtrate 2 and residue 2
(3) Mixing the filter residue 1 and the filter residue 2 with the hawthorn in parts by weight, adding 4 times of water by weight, boiling with big fire, then boiling with small fire for 1 hour, and filtering under reduced pressure while the mixture is hot to obtain a filtrate 3;
(4) Mixing the filtrate 1, the filtrate 2 and the filtrate 3,4, centrifuging at low temperature of 8000r/min for 10min, and recovering supernatant to obtain total filtrate;
(5) Mixing the total filtrate with erythritol, sorbitol, honey and citric acid to obtain final beverage, and diluting with water if necessary to make the content of the beverage 0.1g/mL.
Example 4
Different from the embodiment 1, in the step (5), fruit juice is further added, and the fruit juice added in the embodiment is orange juice. The step (5) is specifically as follows:
peeling fructus Citri Tangerinae, placing in a juicer, and filtering with gauze to obtain juice stock solution. Subjecting the juice stock solution to low temperature ultracentrifugation (4 deg.C, 8000r/min,10 min). Centrifuging, and collecting supernatant to obtain orange juice. Adding orange juice with volume 0.05 times of the total volume of the beverage into the beverage to obtain the final beverage product.
Comparative examples 1 to 5
In comparative examples 1 to 5, the formulation of the composition is shown in Table 1 in parts by weight, and the drink was prepared in accordance with example 1.
Comparative example 6
Different from the embodiment 1, the preparation method of the drink preparation is different, and the specific steps comprise:
(1) Cleaning radix Pseudostellariae, atractylodis rhizoma, pericarpium Citri Tangerinae, fructus Hordei Germinatus, semen lablab album, fructus Citri, flos Bombacis Malabarici, and fructus crataegi, cutting into small pieces, soaking in 12 times of water for 40min, boiling with strong fire, boiling with slow fire for 2.5 hr, and filtering under reduced pressure to obtain filtrate and residue;
(2) Centrifuging the filtrate at 4 deg.C for 10min at 8000r/min, and recovering supernatant to obtain total filtrate; (3) And (3) uniformly mixing the total filtrate with erythritol, sorbitol, honey and citric acid, and adding water for dilution if necessary, so that the medicine content of the beverage is consistent with that of the beverage in the example 1, thereby obtaining the final beverage.
Test 1 sensory evaluation of flavor
Sensory evaluation of flavor, color and mouthfeel was performed on the beverages prepared from the compositions of examples 1 to 3 and comparative examples 1 to 6.
Evaluation of the population: 20 healthy people of 18-60 years old; wherein, 10 male, 10 female, non-pregnant woman and lactating mother; no other metabolic diseases, digestive system diseases, endocrine system diseases, mental diseases and the like; no history of allergy and intolerance to the food to be tested; nutrient supplements affecting glucose tolerance, oral contraceptives, acetylsalicylic acid, steroids, protease inhibitors and antipsychotics were not taken for nearly 3 months. And (5) uniformly carrying out professional sensory evaluation training. After the evaluation population drinks one beverage, the evaluation population drinks a large amount of water to rinse the mouth, and the drinking interval time of the two beverages is more than 6 hours.
After the drink is prepared, the drink is placed into a refrigerator with the temperature of 10 ℃ for refrigeration for 2 hours for eating. The evaluation is given in table 2, the evaluation criteria are given in table 3, and the numbers in table 3 represent: of the 20 evaluators, some of the evaluators considered that the odor, color and taste belonged to category 1, category 2, category 3 and category 4, respectively.
TABLE 2
TABLE 3
Experiment 2 animal experiment-comparison of Small intestine Impulse Rate and stomach evacuation Rate
Test samples: drink test animals prepared with the compositions of examples 1-3 and comparative examples 1-6: 132 SPF-class mice, each half of male and female, weighing 18. + -.2 g, were randomly divided into 11 groups of 12 mice each, blank control group, model group, experimental group (examples 1-3 and comparative examples 1-6).
Constructing a Functional Dyspepsia (FD) mouse model of spleen-stomach qi deficiency. Mice develop the following symptoms: emotional agitation and irritability; squinting (eyes are only exposed by more than half); loss of appetite and decreased appetite; slow, even reduced, weight gain; bunching, bowing back and laziness; the hair color is dark yellow, and the hair is rough and disordered; when the excrement is dry, the excrement is thin, and the reaction of drawing the tail and discharging the excrement is positive; listlessness, lassitude and others indicate successful molding.
The Blank (BC) group was gavaged daily with 0.2ml of normal saline for 15 days.
Except for the blank group, the rest groups adopt diet failure (diet for daytime), exercise and qi consumption (swimming for 30 min) and feeding senna leaves for 0.4g/d (bitter and cold for purgation, qi consumption and qi exhaustion). Before daily feeding, the medicine is taken according to the body weight, the medicine is taken after swimming, the medicine is taken for a fixed time every day, and the stomach is continuously infused for 15 days to prepare a functional dyspepsia mouse model for deficiency of spleen-stomach qi.
The experimental method comprises the following steps: after the administration on the 29 th day, the mice in each group were administered with 0.5mL of powdered carbon semisolid paste (powdered carbon and peanut powder blended in a ratio of 1: 4) after fasting for 24 h. After 1h, the cells were sacrificed and the relevant organs and serum were collected and stored at-80 ℃. Anesthetizing the mouse, collecting blood from eyeball, standing in 1.5mL centrifuge tube at room temperature for 1h, centrifuging at 3000r/min at 4 deg.C for 15min to obtain serum, subpackaging, storing, and storing in-80 deg.C refrigerator for use. Immediately after blood collection, the mice were sacrificed by dislocation of cervical vertebrae, the abdomen of the mice was cut with surgical scissors, and the liver, stomach, small intestine, colon contents and colon were collected. Dissecting and ligating the cardia and pylorus of the stomach, taking the complete stomach, wiping the stomach with filter paper, weighing the mass as the mass of the whole stomach, then cutting the stomach body along the small curve of the stomach, washing the stomach contents with physiological saline, drying the stomach contents with the filter paper, weighing the mass as the mass of the empty stomach, and calculating the gastric emptying rate by using the difference of the weighed masses 2 times before and after. The entire small intestine will be removed from the pylorus to the ileocecal region. The total length of the small intestine and the moving distance of the carbon powder semisolid paste in the small intestine are respectively measured by a steel ruler, and the small intestine propulsion rate is calculated according to the length ratio of 2 times.
The results of the measurements of the rate of small intestine propulsion and the rate of gastric emptying are shown in Table 4.
The results of mouse feeding are shown in FIGS. 1 to 5, in which FIGS. 1 to 2 are mice of blank group and model group, respectively, and FIGS. 1 to 3 are mice of examples 1 to 3, respectively. After the administration of the mice for 29 days, the feces of the mice of examples 1-3 were returned from wet to a relatively dry, granulated state, indicating that the effect of promoting diuresis was good.
TABLE 4
| Group of | Small intestine propulsion rate% | The emptying rate of the stomach% |
| Blank group | 84.41±9.39 | 60.11±6.14 |
| Model set | 77.07±11.56 | 60.03±4.83 |
| Example 1 | 89.15±4.30 | 60.80±1.77 |
| Example 2 | 78.72±8.05 | 59.12±4.78 |
| Example 3 | 91.04±2.43 | 56.84±5.18 |
| Example 4 | 77.01±6.15 | 56.93±4.17 |
| Comparative example 1 | 76.95±3.13 | 54.48±3.15 |
| Comparative example 2 | 88.07±5.16 | 53.73±10.16 |
| Comparative example 3 | 88.44±6.13 | 52.58±10.96 |
| Comparative example 4 | 90.14±11.01 | 56.77±9.84 |
| Comparative example 5 | 76.89±11.49 | 59.48±2.47 |
| Comparative example 6 | 77.65±10.24 | 58.45±5.22 |
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The digestion-aiding composition is characterized by comprising the following components in parts by weight: 1-6 parts of radix pseudostellariae, 1-6 parts of kapok, 1-6 parts of bighead atractylodes rhizome, 1-6 parts of dried orange peel, 4-10 parts of hawthorn, 4-10 parts of malt, 4-10 parts of white hyacinth bean, 3-10 parts of citron, 4-15 parts of erythritol, 3-10 parts of sorbitol, 2-10 parts of honey and 0.05-1 part of citric acid.
2. The composition according to claim 1, wherein the composition comprises the following components in parts by weight: 2-4 parts of radix pseudostellariae, 3-5 parts of common bombax flower, 2-4 parts of bighead atractylodes rhizome, 2-4 parts of dried orange peel, 5-7 parts of hawthorn, 6-8 parts of malt, 4-6 parts of white hyacinth bean, 4-6 parts of citron, 6-12 parts of erythritol, 4-8 parts of sorbitol, 4-8 parts of honey and 0.1-0.5 part of citric acid.
3. The composition according to claim 2, wherein the composition comprises the following components in parts by weight: 3 parts of radix pseudostellariae, 4 parts of common bombax flower, 3 parts of bighead atractylodes rhizome, 3 parts of dried orange peel, 6 parts of hawthorn, 7 parts of malt, 5 parts of white hyacinth bean, 5 parts of citron, 10 parts of erythritol, 6 parts of sorbitol, 5 parts of honey and 0.2 part of citric acid.
4. A process for the preparation of a composition according to any one of claims 1 to 3, characterized in that it comprises the steps of:
(1) Soaking radix Pseudostellariae, atractylodis rhizoma, pericarpium Citri Tangerinae, fructus Hordei Germinatus, semen lablab album, and fructus Citri in water, decocting, and filtering to obtain filtrate 1 and residue 1;
(2) Decocting flos Bombacis Malabarici in water, and filtering while hot to obtain filtrate 2 and residue 2
(3) Mixing the filter residue 1 and the filter residue 2 with the hawthorn, adding water for decoction, and filtering while hot to obtain a filtrate 3;
(4) Mixing the filtrate 1, the filtrate 2 and the filtrate 3, and centrifuging to recover a supernatant to obtain a total filtrate;
(5) Mixing the total filtrate with erythritol, sorbitol, mel, and citric acid to obtain beverage.
5. The method according to claim 4, wherein in step (1), the soaking is carried out for 20-90min, wherein the weight ratio of radix Pseudostellariae, atractylodis rhizoma, pericarpium Citri Tangerinae, fructus Hordei Germinatus, semen lablab album and fructus Citri to water is 1:2-12.
6. The preparation method according to claim 4, wherein in the step (1), the decoction is carried out by boiling with strong fire and then boiling with slow fire for 0.5-2h.
7. The preparation method according to claim 4, wherein in the step (2), the decocting with water is carried out by: the weight ratio of the common bombax flower to the water is 1:1-5, and the common bombax flower is decocted for 20-60min with soft fire.
8. The preparation method according to claim 4, wherein in the step (3), the step of decocting with water is specifically that 1-10 times of water is added into the mixed filter residue and the hawthorn, and after the mixture is boiled with strong fire, the mixture is boiled with small fire and kept for 0.5-2 hours.
9. The preparation method according to claim 4, wherein in the step (4), the supernatant is recovered by centrifugation, specifically, low temperature centrifugation at 2-6 ℃,6000-8000r/min,5-15min.
10. A beverage having the effects of regulating gastrointestinal motility, promoting gastrointestinal digestion and absorption, promoting gastrointestinal emptying, and invigorating qi, spleen and digestion, which is prepared by the preparation method of any one of claims 4 to 9.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497686A (en) * | 2015-12-26 | 2016-04-20 | 悦康药业集团安徽天然制药有限公司 | Stomach invigorating and digestion promoting medicine |
| CN107307400A (en) * | 2017-06-27 | 2017-11-03 | 江苏康缘药业股份有限公司 | It is a kind of that there is composition of promotion digestive function and preparation method thereof |
| CN110898184A (en) * | 2019-12-02 | 2020-03-24 | 遵义市中医院 | Processing method for preparing lollipop by using traditional Chinese medicine ointment formula |
| CN110934971A (en) * | 2019-12-04 | 2020-03-31 | 江苏康缘药业股份有限公司 | Composition with digestion promoting function and preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497686A (en) * | 2015-12-26 | 2016-04-20 | 悦康药业集团安徽天然制药有限公司 | Stomach invigorating and digestion promoting medicine |
| CN107307400A (en) * | 2017-06-27 | 2017-11-03 | 江苏康缘药业股份有限公司 | It is a kind of that there is composition of promotion digestive function and preparation method thereof |
| CN110898184A (en) * | 2019-12-02 | 2020-03-24 | 遵义市中医院 | Processing method for preparing lollipop by using traditional Chinese medicine ointment formula |
| CN110934971A (en) * | 2019-12-04 | 2020-03-31 | 江苏康缘药业股份有限公司 | Composition with digestion promoting function and preparation method and application thereof |
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