CN115917318A - 用于检测生物样品中的血红蛋白的石墨烯基传感器 - Google Patents

用于检测生物样品中的血红蛋白的石墨烯基传感器 Download PDF

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Publication number
CN115917318A
CN115917318A CN202180024705.5A CN202180024705A CN115917318A CN 115917318 A CN115917318 A CN 115917318A CN 202180024705 A CN202180024705 A CN 202180024705A CN 115917318 A CN115917318 A CN 115917318A
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Prior art keywords
graphene layer
hemoglobin
sample
sensor
functionalized
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Pending
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CN202180024705.5A
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Chinese (zh)
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N·纳瓦娜
M·阿贝迪
R·莫拉格哈巴巴
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GrapheneDx Inc
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GrapheneDx Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
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    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/726—Devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
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    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
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    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins

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  • Inorganic Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN202180024705.5A 2020-02-06 2021-02-08 用于检测生物样品中的血红蛋白的石墨烯基传感器 Pending CN115917318A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970919P 2020-02-06 2020-02-06
US62/970,919 2020-02-06
PCT/US2021/017082 WO2021159074A1 (en) 2020-02-06 2021-02-08 Graphene-based sensor for detecting hemoglobin in a biological sample

Publications (1)

Publication Number Publication Date
CN115917318A true CN115917318A (zh) 2023-04-04

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CN202180024705.5A Pending CN115917318A (zh) 2020-02-06 2021-02-08 用于检测生物样品中的血红蛋白的石墨烯基传感器

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US (1) US20210247409A1 (https=)
EP (1) EP4100739A1 (https=)
JP (1) JP2023513543A (https=)
KR (1) KR20220136407A (https=)
CN (1) CN115917318A (https=)
AU (1) AU2021216478A1 (https=)
CA (1) CA3170353A1 (https=)
WO (1) WO2021159074A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12546746B2 (en) * 2021-05-05 2026-02-10 Ekidna Sensing Inc. Systems and devices for estimating substance concentration
US20230182133A1 (en) * 2021-12-01 2023-06-15 Graphene-Dx. Inc. Systems and methods for processing and testing biological samples
WO2025024598A1 (en) * 2023-07-24 2025-01-30 The Regents Of The University Of California Biomarker detection using graphene field effect transistor sensor arrays and multichannel data acquisition

Citations (6)

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US5198365A (en) * 1987-02-04 1993-03-30 International Immunoassay Laboratories, Inc. Fecal sample immunoassay method testing for hemoglobin
US20180116641A1 (en) * 2015-04-24 2018-05-03 Maat Pharma Microorganism sampling method, microorganism sampling device and sampling kit comprising such a sampling device
CN108241012A (zh) * 2016-12-27 2018-07-03 中国科学院金属研究所 基于石墨烯的血红蛋白传感器电极的制备方法及其应用
US20180317892A1 (en) * 2015-10-03 2018-11-08 George Catlin Stool collection, containment, and specimen disbursement system
US20190317081A1 (en) * 2014-10-03 2019-10-17 Rite Taste, LLC Device and Method for Chemical Analysis
US20200011860A1 (en) * 2018-05-24 2020-01-09 Rite Taste, LLC Functionalized Sensor for Detection of Biomarkers

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KR20110113610A (ko) * 2008-12-05 2011-10-17 나노아이브이디, 인크. 현장진단 분석기를 위한 미세유체 기반의 랩온어 테스트 카드
US8702931B2 (en) * 2011-04-18 2014-04-22 Indian Institute Of Science Low cost electrochemical disposable sensor for measuring glycated hemoglobin
EP4234722A3 (en) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US9664674B2 (en) * 2014-10-03 2017-05-30 Rite Taste, LLC Device and method for chemical analysis
US10335787B2 (en) * 2014-10-16 2019-07-02 The General Hospital Corporation Specimen acceptance devices and attachable disposable assay cartridges
KR101906447B1 (ko) * 2016-07-20 2018-10-11 한국과학기술연구원 전계효과 대장암 센서
US10456787B2 (en) * 2016-08-11 2019-10-29 Instrumentation Laboratory Company Reagent component dispensing caps for reagent containers used in automated clinical analyzers
KR20190072520A (ko) * 2016-10-24 2019-06-25 도레이 카부시키가이샤 반도체 센서 및 그의 제조 방법, 그리고 복합 센서
CN109097471A (zh) * 2018-08-21 2018-12-28 杭州和壹基因科技有限公司 一种用于结直肠癌及癌前病变检测的试剂盒及其使用方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198365A (en) * 1987-02-04 1993-03-30 International Immunoassay Laboratories, Inc. Fecal sample immunoassay method testing for hemoglobin
US20190317081A1 (en) * 2014-10-03 2019-10-17 Rite Taste, LLC Device and Method for Chemical Analysis
US20180116641A1 (en) * 2015-04-24 2018-05-03 Maat Pharma Microorganism sampling method, microorganism sampling device and sampling kit comprising such a sampling device
US20180317892A1 (en) * 2015-10-03 2018-11-08 George Catlin Stool collection, containment, and specimen disbursement system
CN108241012A (zh) * 2016-12-27 2018-07-03 中国科学院金属研究所 基于石墨烯的血红蛋白传感器电极的制备方法及其应用
US20200011860A1 (en) * 2018-05-24 2020-01-09 Rite Taste, LLC Functionalized Sensor for Detection of Biomarkers

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KR20220136407A (ko) 2022-10-07
EP4100739A1 (en) 2022-12-14
CA3170353A1 (en) 2021-08-12
US20210247409A1 (en) 2021-08-12
WO2021159074A1 (en) 2021-08-12
JP2023513543A (ja) 2023-03-31
AU2021216478A1 (en) 2022-09-08

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