CN115916238A - 包含胰高血糖素/GLP-l/GIP受体三重激动剂或其缀合物的高血脂症预防或治疗组合物及其使用方法 - Google Patents

包含胰高血糖素/GLP-l/GIP受体三重激动剂或其缀合物的高血脂症预防或治疗组合物及其使用方法 Download PDF

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CN115916238A
CN115916238A CN202180038989.3A CN202180038989A CN115916238A CN 115916238 A CN115916238 A CN 115916238A CN 202180038989 A CN202180038989 A CN 202180038989A CN 115916238 A CN115916238 A CN 115916238A
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cysteine
ser
glutamine
gln
gly
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曹孝相
金正国
李雅揽
金尚允
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Hanmi Pharmaceutical Co Ltd
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Hanmi Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • C07K14/575—Hormones
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

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  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
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  • Vascular Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202180038989.3A 2020-04-20 2021-04-20 包含胰高血糖素/GLP-l/GIP受体三重激动剂或其缀合物的高血脂症预防或治疗组合物及其使用方法 Pending CN115916238A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20200047733 2020-04-20
KR10-2020-0047733 2020-04-20
PCT/KR2021/004961 WO2021215801A1 (ko) 2020-04-20 2021-04-20 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체를 포함하는 고지혈증 예방 또는 치료용 약학적 조성물 및 예방 또는 치료 방법

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CN115916238A true CN115916238A (zh) 2023-04-04

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CN202180038989.3A Pending CN115916238A (zh) 2020-04-20 2021-04-20 包含胰高血糖素/GLP-l/GIP受体三重激动剂或其缀合物的高血脂症预防或治疗组合物及其使用方法

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Country Link
US (1) US20230158117A1 (https=)
EP (1) EP4140496A4 (https=)
JP (1) JP2023521491A (https=)
KR (1) KR20210129614A (https=)
CN (1) CN115916238A (https=)
AU (1) AU2021203645B2 (https=)
BR (1) BR112022020531A2 (https=)
CA (1) CA3174423A1 (https=)
IL (1) IL296960A (https=)
MX (1) MX2022012847A (https=)
TW (1) TW202203963A (https=)
WO (1) WO2021215801A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230095665A (ko) * 2021-12-22 2023-06-29 한미약품 주식회사 간 표적 약물 및 이의 용도
KR20250177375A (ko) * 2024-06-13 2025-12-23 한미약품 주식회사 Glp-1, gip, 및 글루카곤 수용체 모두에 활성을 갖는 삼중 활성체 및 이를 포함하는 지질 대사 질환 예방 또는 치료용 약학적 조성물
WO2026082095A1 (en) * 2024-10-17 2026-04-23 Innovent Biologics (Suzhou) Co., Ltd. Compounds for treating metabolic disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3010265A1 (en) * 2015-12-31 2017-07-06 Hanmi Pharm. Co., Ltd. Long-acting conjugate of triple glucagon/glp-1/gip receptor agonist
WO2018100135A1 (en) * 2016-12-02 2018-06-07 Sanofi New compounds as peptidic glp1/glucagon/gip receptor agonists
CN109641035A (zh) * 2016-06-29 2019-04-16 韩美药品株式会社 胰高血糖素衍生物、其缀合物、包含其的组合物、和其治疗用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
EP1667724A2 (en) * 2003-09-19 2006-06-14 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
JP2009534423A (ja) * 2006-04-20 2009-09-24 アムジェン インコーポレイテッド Ｇｌｐ−１化合物
AU2013366692B2 (en) * 2012-12-21 2017-11-23 Sanofi Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
CN105829339B (zh) * 2013-11-06 2021-03-12 西兰制药公司 胰高血糖素-glp-1-gip三重激动剂化合物
SG11202001283PA (en) * 2017-08-16 2020-03-30 Dong A St Co Ltd Acylated oxyntomodulin peptide analog

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3010265A1 (en) * 2015-12-31 2017-07-06 Hanmi Pharm. Co., Ltd. Long-acting conjugate of triple glucagon/glp-1/gip receptor agonist
CN108699125A (zh) * 2015-12-31 2018-10-23 韩美药品株式会社 激活胰高血糖素、glp-1和gip受体的三重激活剂
CN109071624A (zh) * 2015-12-31 2018-12-21 韩美药品株式会社 激活胰高血糖素、glp-1和gip受体的三重激活剂的持久缀合物
CN109641035A (zh) * 2016-06-29 2019-04-16 韩美药品株式会社 胰高血糖素衍生物、其缀合物、包含其的组合物、和其治疗用途
WO2018100135A1 (en) * 2016-12-02 2018-06-07 Sanofi New compounds as peptidic glp1/glucagon/gip receptor agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
顾金金;赵铁耘;李秀钧;: "干预胰高血糖素信号通路治疗糖尿病的研究进展", 生理科学进展, no. 04, 25 August 2011 (2011-08-25), pages 13 - 17 *

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TW202203963A (zh) 2022-02-01
AU2021203645A1 (en) 2021-11-04
WO2021215801A1 (ko) 2021-10-28
BR112022020531A2 (pt) 2022-12-06
IL296960A (en) 2022-12-01
EP4140496A4 (en) 2024-05-22
KR20210129614A (ko) 2021-10-28
EP4140496A1 (en) 2023-03-01
US20230158117A1 (en) 2023-05-25
CA3174423A1 (en) 2021-10-28
JP2023521491A (ja) 2023-05-24
MX2022012847A (es) 2022-11-07
AU2021203645B2 (en) 2024-06-27

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