CN115843812A - Insecticidal and acaricidal composition containing spiromesifen and application thereof - Google Patents
Insecticidal and acaricidal composition containing spiromesifen and application thereof Download PDFInfo
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- CN115843812A CN115843812A CN202211662072.3A CN202211662072A CN115843812A CN 115843812 A CN115843812 A CN 115843812A CN 202211662072 A CN202211662072 A CN 202211662072A CN 115843812 A CN115843812 A CN 115843812A
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- Prior art keywords
- insecticidal
- spiromesifen
- formula
- acaricidal composition
- compound
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- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 239000005665 Spiromesifen Substances 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000000895 acaricidal effect Effects 0.000 title claims abstract description 39
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 39
- 150000001875 compounds Chemical class 0.000 claims abstract description 59
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 32
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 28
- 241000238876 Acari Species 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims description 47
- 241000344246 Tetranychus cinnabarinus Species 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 14
- 239000000375 suspending agent Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 12
- 241000526125 Diaphorina citri Species 0.000 claims description 9
- 239000003094 microcapsule Substances 0.000 claims description 8
- 241000196324 Embryophyta Species 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 239000004563 wettable powder Substances 0.000 claims description 7
- 241001414857 Psyllidae Species 0.000 claims description 6
- 241001454295 Tetranychidae Species 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- -1 bars Substances 0.000 claims description 5
- 241001466030 Psylloidea Species 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- 241000488581 Panonychus citri Species 0.000 claims description 2
- 241000344254 Tetranychus truncatus Species 0.000 claims description 2
- 241001454293 Tetranychus urticae Species 0.000 claims description 2
- 239000002518 antifoaming agent Substances 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 239000004536 oil dispersible powder Substances 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000004551 spreading oil Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 239000004565 water dispersible tablet Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 3
- 239000004548 suspo-emulsion Substances 0.000 claims 2
- 241000239290 Araneae Species 0.000 claims 1
- 241000157491 Morinda Species 0.000 claims 1
- 239000007798 antifreeze agent Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 235000017524 noni Nutrition 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000004552 water soluble powder Substances 0.000 claims 1
- 239000004554 water soluble tablet Substances 0.000 claims 1
- 239000000575 pesticide Substances 0.000 abstract description 13
- 230000009471 action Effects 0.000 abstract description 8
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 239000000447 pesticide residue Substances 0.000 abstract description 4
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000001094 effect on targets Effects 0.000 abstract description 2
- 230000002688 persistence Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 41
- 239000003814 drug Substances 0.000 description 14
- 241000238631 Hexapoda Species 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 230000001018 virulence Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000004166 bioassay Methods 0.000 description 6
- 238000004811 liquid chromatography Methods 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 241000207199 Citrus Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241001454294 Tetranychus Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 235000020971 citrus fruits Nutrition 0.000 description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 3
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 239000000642 acaricide Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 229920005552 sodium lignosulfonate Polymers 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- XUJLWPFSUCHPQL-UHFFFAOYSA-N 11-methyldodecan-1-ol Chemical compound CC(C)CCCCCCCCCCO XUJLWPFSUCHPQL-UHFFFAOYSA-N 0.000 description 1
- MLMQPDHYNJCQAO-UHFFFAOYSA-M 3,3-dimethylbutanoate Chemical compound CC(C)(C)CC([O-])=O MLMQPDHYNJCQAO-UHFFFAOYSA-M 0.000 description 1
- 241000132121 Acaridae Species 0.000 description 1
- 241000282817 Bovidae Species 0.000 description 1
- 241000256593 Brachycaudus schwartzi Species 0.000 description 1
- 241000526200 Cacopsylla pyri Species 0.000 description 1
- 241000195620 Euglena Species 0.000 description 1
- 241000258937 Hemiptera Species 0.000 description 1
- 241000725028 Kuwayama Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000751897 Paederus Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229920000142 Sodium polycarboxylate Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000012093 association test Methods 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 239000013538 functional additive Substances 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- PEQJBOMPGWYIRO-UHFFFAOYSA-N n-ethyl-3,4-dimethoxyaniline Chemical compound CCNC1=CC=C(OC)C(OC)=C1 PEQJBOMPGWYIRO-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000007944 soluble tablet Substances 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticide killing and mite killing, and particularly discloses a pesticide and mite killing composition containing spiromesifen, wherein the active ingredients of the pesticide and mite killing composition comprise spiromesifen and a compound shown as a formula I:
Description
Technical Field
The invention belongs to the technical field of pesticide pest and mite killing, and particularly discloses a pest and mite killing composition containing spiromesifen and application thereof.
Background
Spiromesifen, CAS accession No.: 283594-90-1, chemical name is [ 2-subunit-3- (2, 4, 6-trimethylphenyl) -1-oxaspiro [4.4] non-3-en-4-yl ]3, 3-dimethylbutyrate, is a spiro tetronic acid insecticide and acaricide developed by Bayer company, has unique action mechanism, destroys the energy metabolism activity of mites by inhibiting the synthesis of fat in the bodies of the mites, and finally kills the mites. The structural formula is as follows:
the compound of formula I is a novel phenylpyrazole nicotinamide fluorine-containing pesticide with the chemical name of N-methyl-N-cyclopropyl-2-chloro-5- [1- (2, 6-dichloro-4-heptafluoroisopropylphenyl) -pyrazol-4-yl]Nicotinamide of formula C 22 H 14 Cl 3 F 7 N 4 And O. The insecticidal composition has excellent insecticidal effect on lepidoptera pests and acarina pests, has certain control effect on peach aphids of hemiptera pests, and has the following structural formula:
tetranychus is an important phytophagous mite, is an important pest group in agricultural production, belongs to the arachnidae, the acaridae subclass, the euglena, the antelopes and the tetranychus general family, and is easy to outbreak and cause disasters due to the characteristics of small individual, short generation, quick propagation, wide hosts and the like, thereby causing great influence on the yield and quality of vegetables.
The psyllids can occur for several generations in one year, each generation is overlapped, and adult nymphs gather on tender shoots of host plants and are mainly harmed by the sap of leaves, petioles, young shoots and fruits which are sucked by the adult nymphs. When nymphs eat the feed, viscous substances are secreted, so that mildew is bred on leaves, the photosynthesis of the leaves is influenced by light people, and the leaves fall off by heavy people; irregular rusty plaques are formed on fruits, the appearance quality of the fruits is seriously influenced, and even the economic value is lost.
Disclosure of Invention
In order to solve the problems in the prior art, the inventor carries out deep analysis on the spiromesifen and then compounds the spiromesifen with different insecticidal and acaricidal compounds, and surprisingly discovers that: the spiromesifen and the compound shown in the formula I are compounded according to a certain weight ratio, so that a synergistic effect can be generated, the safety and the high efficiency are realized, the insecticidal and acaricidal activity is enhanced, the pesticide use amount is reduced, the control cost is reduced, and the pesticide residue of agricultural products is reduced. The present invention has been completed based on the above findings.
In order to achieve the purpose, the invention is realized by the following technical scheme: an insecticidal and acaricidal composition containing spiromesifen, wherein the active ingredients of the insecticidal and acaricidal composition comprise spiromesifen and a compound shown as a formula I:
further, the mass ratio of the compound of the formula I to the spiromesifen is 1.
Further, the mass ratio of the compound of formula I to spiromesifen is 1, 20, 1, 3, 1, 20;
further, the mass ratio of the compound of the formula I to the spiromesifen is 1;
further, the mass ratio of the compound of formula I to spiromesifen is 1, 5, 1, 3;
furthermore, the mass ratio of the compound of the formula I to the spiromesifen is 1;
further, the mass ratio of the compound of formula I to spiromesifen is 1, 3;
further, the total weight of the insecticidal and acaricidal composition is calculated by 100wt%, and the total weight of the spiromesifen and the compound shown in the formula I as the active ingredients accounts for 2-80% of the total weight of the insecticidal and acaricidal composition;
furthermore, the total weight of the spiromesifen and the compound shown in the formula I as the active ingredients accounts for 2-70% of the total weight of the insecticidal and acaricidal composition;
further, the insecticidal and acaricidal composition also comprises agriculturally acceptable auxiliary ingredients besides the active ingredients, wherein the auxiliary ingredients are selected from one or more of wetting agents, dispersing agents, emulsifying agents, thickening agents, disintegrating agents, antifreezing agents, antifoaming agents, solvents, preservatives, stabilizing agents, synergists or carriers;
furthermore, the insecticidal and acaricidal composition can be prepared into any agriculturally acceptable preparation form, and the preparation form is a solid preparation and/or a liquid preparation;
further, the solid preparation is selected from direct use solid preparations, dispersible solid preparations and/or soluble solid preparations;
further, the directly used solid preparation is powder, granules, pellets, tablets or bars;
the dispersible solid preparation is wettable powder, oil dispersible powder, emulsion powder, water dispersible granules, emulsion granules or water dispersible tablets;
the soluble solid preparation is soluble powder, soluble tablets or soluble granules;
further, the liquid preparation is a solution preparation, a dispersion liquid preparation, an emulsion preparation, a suspension preparation or a multi-phase preparation;
further, the solution preparation is soluble agent, soluble colloid, oil agent or spreading oil agent;
the dispersion liquid preparation is missible oil, latex, dispersible agent or paste;
the emulsion preparation is an aqueous emulsion, an oil emulsion, a microemulsion or a fat agent;
the suspension preparation is a suspending agent, a microcapsule suspending agent, an oil suspending agent or a dispersible oil suspending agent;
the multi-phase preparation is a suspending emulsion, a microcapsule suspension-suspending agent, a microcapsule suspension-water emulsion or a microcapsule suspension-suspending emulsion;
further, the liquid preparation is selected from suspending agents, and the solid preparation is selected from water dispersible granules or wettable powder;
the invention also discloses the application of the insecticidal and acaricidal composition in preventing and treating plant mites;
further, the crop pests are pests of psyllidae, and the plant pest mites are pest mites of tetranychidae;
further, the psyllidae pests are pear psyllids, citrus psyllids or mulberry psyllids, and the tetranychidae pests are tetranychus cinnabarinus, tetranychus urticae koch, tetranychus truncatus and/or panonychus citri;
furthermore, the psyllidae pests are diaphorina citri, and the tetranychidae pests are tetranychus cinnabarinus;
further, the insecticidal and acaricidal composition and/or the preparation thereof are applied to mites or a growth medium thereof.
The invention has the beneficial effects that:
1) The insecticidal and acaricidal composition improves the synergistic effect of the insecticidal and acaricidal agent and improves the control effect on target pests and mites through the matching of the effective components;
2) The insecticidal and acaricidal composition disclosed by the invention simultaneously reduces the control cost, lightens the pollution to the environment, effectively reduces the pesticide residue of the pesticide and reduces the harm to beneficial organisms;
3) The insecticidal and acaricidal composition is superior to a single agent in quick action and persistence, and is beneficial to the comprehensive control of agricultural pests and mites.
Detailed Description
To make the technical solutions, objects, and advantages of the present invention more apparent, the present invention is described with the following specific examples, but the present invention may be implemented in various forms and should not be limited by the embodiments set forth herein.
Preparation examples (the following percentages are by weight)
Preparation example 1:24% compound of formula I spiromesifen suspension (5
The formula is as follows: 20% of a compound shown in the formula I, 4% of spiromesifen, 2% of fatty alcohol-polyoxyethylene ether, 3% of alkylphenol polyoxyethylene phosphate, 1% of polycarboxylate, 0.2% of xanthan gum, 1% of magnesium aluminum silicate, 5% of glycol, 0.01% of benzisothiazolinone, 0.5% of silicone oil and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients, the surfactant and other functional additives are sequentially placed in a reaction kettle, water is added for uniform mixing, and the suspending agent product is obtained through high-speed shearing, wet sanding and finally homogeneous filtration.
Preparation example 2:22% compound of formula I spiromesifen suspension (10
The formula is as follows: 20% of a compound in the formula I, 2% of spiromesifen, 2% of isotridecanol polyoxyethylene ether, 3% of alkylphenol polyoxyethylene ether phosphate, 1% of succinate sulfonate, 2% of block polyether, 0.2% of xanthan gum, 1% of magnesium aluminum silicate, 4% of propylene glycol, 0.2% of sodium benzoate, 0.5% of silicone oil and the balance of deionized water.
The preparation method comprises the following steps: the same as in preparation example 1.
Preparation example 3:30% of formula I compound spiromesifen water dispersible granule (1
The formula is as follows: 15% of a compound in the formula I, 15% of spiromesifen, 10% of sodium lignosulfonate, 2% of sodium polycarboxylate, 2% of nekal BX, 5% of anhydrous sodium sulfate and the balance of kaolin.
The preparation method comprises the following steps: adding active ingredients into a carrier according to a formula ratio, adding a surfactant and other functional auxiliaries, mixing, adding 10-25% of water after airflow crushing, kneading, granulating, drying and screening to obtain a water dispersible granule product; or spraying water to the pulverized powder in a boiling granulator, granulating, drying, and sieving to obtain the final product.
Preparation example 4:36% of the compound of formula I, spiromesifen water dispersible granule (3
The formula is as follows: 27% of a compound in the formula I, 9% of spiromesifen, 2% of sodium dodecyl benzene sulfonate, 8% of a naphthalenesulfonate formaldehyde condensate, 2% of nekal BX, 5% of urea and kaolin for balancing.
The preparation method comprises the following steps: the same as in preparation example 3.
Preparation example 5:40% Compound of formula I spiromesifen wettable powder (1
The formula is as follows: 10% of a compound of a formula I, 30% of spiromesifen, 4% of sodium lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 1% of nekal BX, 6% of white carbon black and kaolin for balancing;
the preparation method comprises the following steps: the effective components, the dispersant, the wetting agent and the filler are mixed according to the formula proportion, evenly stirred in a stirring kettle, and are smashed and evenly mixed for a plurality of times by a jet mill, so as to prepare the wettable powder of the composition.
Preparation example 6:27% Compound of formula I spiromesifen wettable powder (1
The formula is as follows: 13.5% of a compound in the formula I, 13.5% of spiromesifen, 5% of calcium lignosulfonate, 4% of sodium dodecyl benzene sulfonate, 5% of white carbon black and the balance of kaolin.
The preparation method comprises the following steps: the same as in preparation example 5.
Indoor activity test
Example 1: indoor bioassay test of tetranychus cinnabarinus compounded by spiromesifen and compound shown in formula I
The test basis is as follows: the test is referred to NY/T1154.12-2008 pesticide part 12 of indoor bioassay test criteria for pesticides: tetranychus slide impregnation method, NY/T1154.7-2006 "indoor bioassay of pesticides test guidelines section 7: combined action assay of compounding.
Test targets: tetranychus cinnabarinus (Tetranychus cinnabarinus Boisdival).
Test agents: 98% of spiromesifen and 92% of the compound of formula I, which are provided by the Helier pharmaceutical industry group research and development center.
Preparing a test material: cutting the double-sided adhesive into 2cm long, sticking to one end of the glass slide, selecting healthy adult mites, sticking the backs of the adult mites to the double-sided adhesive (without sticking mite feet, tentacles and mouthpieces), placing 30 heads of each adult mite in a container filled with wet sponge, covering the container with a cover, and placing at the temperature of (25 +/-1) ° C. Performing microscopic examination after 2h, removing dead and injured individuals, and supplementing 30 heads of each tablet.
Preparing a medicament: dissolving the above raw materials with appropriate solvent, and preparing appropriate mass concentration gradient according to the activity of the medicine by an equal ratio method.
Medicament treatment: soaking the glass slide in the liquid medicine, slightly shaking for 5s, taking out, sucking off excessive liquid medicine with absorbent paper, placing in a white porcelain dish padded with wet sponge, and covering with plastic film with good light transmittance. Each treatment was repeated 4 times and a blank was set with no agent (containing all organic solvents and emulsifiers).
Feeding and observing: and (3) placing the container containing the test insects in a condition that the temperature is (25 +/-1) DEG C, the photoperiod is L: D = (16) h, and feeding and observing the test insects.
And (4) checking: and (5) checking the death condition of the test insects 48 hours after treatment, and respectively recording the total number of the insects and the number of the dead insects.
Data statistics and analysis:
the calculation method comprises the following steps: based on the survey data, the corrected mortality for each treatment was calculated according to equations (1) and (2).
In the formula:
p-mortality in percent (%);
k is the number of dead insects, with the unit being head;
n-number of insects in treatment, unit is head;
in the formula:
P 1 corrected mortality in percent (%);
P t treatment mortality in percent (%);
P 0 blank mortality in percent (%).
If the control mortality rate is less than 5%, correction is not needed; the control mortality rate is between 5% and 20%, and the correction is carried out according to the formula (2); control mortality was > 20% and the test was redone.
The test is carried out by adopting a DPS statistical analysis system to obtain LC 50 The activity of the test agent on the biological sample is evaluated.
The co-toxicity coefficient (CTC value) of the mixture is calculated according to the formulas (3), (4) and (5):
in the formula:
ATI-actually measured toxicity index of mixed agent;
S-LC of Standard Agrochemical 50 In milligrams per liter (mg/L);
LC of M-mixtures 50 In milligrams per liter (mg/L).
TTI＝TI A ×P A +TI B ×P B ·······(4)
In the formula:
TTI-mixture theory virulence index;
TI A -agent virulence index a;
P A -the percentage of agent a in the mixture in percent (%);
TI B -agent B virulence index;
P B -the percentage of the agent B in the mixture in percent (%).
In the formula:
CTC-co-toxicity coefficient;
ATI-actually measured toxicity index of mixed agent;
TTI-mixture theory virulence index.
The compounded co-toxicity coefficient CTC is more than or equal to 120, and the synergistic effect is shown; CTC is less than or equal to 80 and shows antagonism; 80 < CTC < 120 showed additive effects. The indoor association test is shown in the following table:
TABLE 1 indoor bioassay test results of Compound Paederus cinnabarinus of Spiromesifen and Compound I
As can be seen from the test results in the upper table, the insecticidal and acaricidal composition has good control effect on tetranychus cinnabarinus, the toxicity of the compound in the formula I on tetranychus cinnabarinus is high, and LC (liquid chromatography) of the compound in the formula I 50 It was 2.7002mg/L. The mass ratio of the compound of the formula I to the spiromesifen is 1-20 to 40, the co-toxicity coefficient (CTC) is more than 120, and the combined action shows synergy; the mass ratio of the compound of the formula I to the spiromesifen is 1-40, the co-toxicity coefficient is more than 130, and the synergy is obvious; the mass ratio of the compound of the formula I to the spiromesifen is 1.
Example 2: indoor bioassay test for compound pairing of spiromesifen and compound of formula I to diaphorina citri
The test method comprises the following steps: the leaf soaking method is adopted.
Test targets: diaphorina citri (Diaphorina citri Kuwayama).
Test reagents: 98% of spiromesifen and 92% of the compound of formula I, which are provided by the Helier pharmaceutical industry group research and development center.
Preparing a medicament: preparing single-dose mother liquor respectively, designing proper proportion according to the mixing purpose and the medicament activity, and preparing the single dose and each group of proportion mixture into required series of mass concentrations.
The testing steps are as follows:
(1) Preparing a test material: selecting mature citrus leaves which are not sprayed with any medicament and grow well and have complete shapes, cleaning and airing.
(2) Treating a medicament: soaking the citrus leaves in the treated liquid medicine for 10s respectively, setting a Tween 80 aqueous solution which does not contain a medicament and contains a corresponding solvent as a blank control, airing, placing in a culture dish with the diameter of 9cm for later use (1 leaf in each dish), wrapping the petiole base of the citrus leaves with absorbent cotton containing water for moisture preservation, placing filter paper containing a proper amount of water at the bottom of the culture dish, and keeping the appropriate humidity in the culture dish.
(3) Inoculating insects: and (3) inserting the test insects to the leaves of each treatment by using a writing brush, covering the culture dish by using a gauze, covering a dish cover (a small hole is reserved on the dish cover) with 20 test insects on each leaf, repeating each treatment for 4 times, and culturing in an artificial climate box with the temperature of 25 +/-1 (DEG C), the relative humidity of 65 +/-5 percent and the photoperiod L: D = 14: 10.
(4) And (3) investigation:
after 48h of treatment, the number of live insects per treatment was individually checked and recorded. From the survey data, corrected mortality for each treatment was calculated.
(6) Data statistics and analysis:
the corrected mortality was calculated according to equations (1) and (2):
in the formula:
p-mortality in percent (%);
k-represents the number of dead insects, in head;
n-represents the total number of insects treated, in heads.
In the formula:
P 1 corrected mortality in% is reported;
P t treatment mortality in percent (%)；
P 0 Blank mortality in percent (%).
If the control mortality rate is less than 5%, no correction is needed; the control mortality rate is between 5% and 20%, and the correction is carried out according to the formula (2); control mortality was > 20%, and the test was redone.
And processing the data by adopting a method of analyzing a few rate value. Analyzing with DPS statistical analysis system to obtain LC 50 The activity of the test agent on the biological sample is evaluated.
The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula (3), formula (4) and formula (5):
in the formula:
ATI-actually measured toxicity index of mixed agent;
S-LC of standard agricultural agents 50 In milligrams per liter (mg/L);
LC of M-mixtures 50 Units are milligrams per liter (mg/L).
TTI＝TI A *P A +TI B *P B .······(4)
In the formula:
TTI-mixture theory virulence index;
TI A -agent virulence index a;
P A -the percentage of agent a in the mixture in percent (%);
TI B -agent B virulence index;
P B -the percentage of the agent B in the mixture in percent (%).
In the formula:
CTC-co-toxicity coefficient;
ATI-actually measured toxicity index of mixed agent;
TTI-mixture theory virulence index.
The compounded co-toxicity coefficient CTC is more than or equal to 120, and the synergistic effect is shown; CTC is less than or equal to 80 and shows antagonism; 80 < CTC < 120 showed additive effects.
The laboratory test results are shown in the following table:
TABLE 2 indoor bioassay test results of compound pairing of spiromesifen and compound of formula I to diaphorina citri
| Drug treatment | LC 50 (mg/L) | ATI | TTI | Co-toxicity coefficient (CTC) |
| A compound of formula I | 8.3305 | 17.359 | - | / |
| Spiromesifen | 1.4461 | 100.000 | - | / |
| Compound of formula I spiromesifen = 120 | 1.1475 | 958.606 | 96.065 | 131.184 |
| Compound of formula I spiromesifen =1 | 1.0791 | 1019.368 | 92.487 | 144.896 |
| Compound of formula I spiromesifen =1 | 0.9671 | 1137.421 | 86.227 | 173.415 |
| Compound of formula I spiromesifen =1 | 1.3707 | 802.510 | 58.680 | 179.791 |
| Compound of formula I spiromesifen =10 | 3.4902 | 315.168 | 24.872 | 166.586 |
| Compound of formula I spiromesifen =30 | 4.9348 | 222.907 | 20.025 | 146.338 |
| Compound of formula I spiromesifen =40 | 5.9515 | 184.827 | 19.375 | 125.411 |
As can be seen from the indoor test results in the table above, the insecticidal and acaricidal composition provided by the invention also has a good control effect on diaphorina citri, the mass ratio of the compound in the formula I to the spiromesifen is 1-20-40, the co-toxicity coefficient (CTC) is more than 120, and the combined action shows synergy.
Test of field drug effect
Example 3: compound of spiromesifen and compound of formula I is used for field efficacy test of tetranychus cinnabarinus
The test basis is as follows: the test is carried out according to GB/T17980.17-2000 'acaricide control bean and vegetable spider mites in pesticide field efficacy test criterion (I)'.
Test targets: tetranychus cinnabarinus (Tetranychus cinnabarinus Boisdival).
Test crops and varieties: potato (netherlands No. 15).
Test site: in the potato fields of Pangjiayuncun of Fuxing town of Gansu province, the soil in the test field is yellow-cotton soil, the fertility is moderate, the terrain is flat, and the previous crop is corn.
The test method comprises the following steps: area of test cell 20m 2 Each treatment was repeated 4 times. The test is carried out in 2019, 7, 10 and 10 days, pesticide is sprayed by a worker-farm-16 knapsack sprayer, and the whole plant is sprayed uniformly to ensure that all leaves are uniformly sprayed. The liquid medicine application amount is 750L/hm 2 。
Test investigation: the population number of Tetranychus cinnabarinus was examined before the test application, and 3d, 7d and 14d after the test application were examined once for 4 times in total. And (4) fixedly selecting 20 tetranychid leaves in each cell during investigation, investigating the number of live mites, and calculating the control effect.
The drug effect calculation method comprises the following steps:
the results of the field efficacy test are shown in the following table:
TABLE 3 field efficacy test results of the combination of spiromesifen and the compound of formula I on Tetranychus cinnabarinus
The field efficacy test results show that the insecticidal and acaricidal composition has good control effect on tetranychus cinnabarinus. And 3d after the medicine is applied, the treatment and prevention effect of each preparation example is higher than 70%, and the quick action is better. After application, 14d,24% of the compound of the formula I, spiromesifen suspending agent (5).
The results of indoor tests and field pesticide effects show that the insecticidal and acaricidal composition has good control effect on common pests or tetranychid mites such as diaphorina citri, tetranychus cinnabarinus and the like. The preparation has the advantages of good quick action, long lasting period, safety and high efficiency, enhances the insecticidal and acaricidal activity, reduces the pesticide consumption, reduces the control cost and reduces the pesticide residue of agricultural products.
Claims (10)
1. The insecticidal and acaricidal composition containing the spiromesifen is characterized in that the active ingredients of the insecticidal and acaricidal composition comprise the spiromesifen and a compound shown in a formula I:
2. an insecticidal and acaricidal composition according to claim 1, wherein the mass ratio of the compound of formula I to spiromesifen is 1.
3. An insecticidal and acaricidal composition according to claim 1, wherein the mass ratio of the compound of formula I to spiromesifen is 1;
preferably, the mass ratio of the compound of the formula I to the spiromesifen is 1.
4. An insecticidal and acaricidal composition according to claim 1, wherein the total weight of the insecticidal and acaricidal composition is 100wt%, and the total weight of the spiromesifen and the compound of formula I as the active ingredients accounts for 2 to 80%, preferably 2 to 70% of the total weight of the insecticidal and acaricidal composition.
5. An insecticidal and acaricidal composition according to claim 1, wherein said insecticidal and acaricidal composition further comprises, in addition to the active ingredient(s), agriculturally acceptable auxiliary ingredients selected from one or more of wetting agents, dispersing agents, emulsifiers, thickeners, disintegrants, antifreeze agents, antifoaming agents, solvents, preservatives, stabilizers, synergists or carriers.
6. The insecticidal and acaricidal composition according to claim 1, wherein said insecticidal and acaricidal composition can be prepared into any agriculturally acceptable formulation, and said formulation can be solid or liquid;
the solid preparation comprises powder, granules, pellets, tablets, bars, wettable powder, oil dispersible powder, emulsion powder, water dispersible granules, emulsion granules, water dispersible tablets, soluble powder, soluble tablets or soluble granules;
the liquid preparation comprises a soluble agent, a soluble gum agent, an oil agent, a spreading oil agent, missible oil, latex, a dispersible agent, an ointment, an aqueous emulsion, an oil emulsion, a microemulsion, a fatliquor suspending agent, a microcapsule suspending agent, an oil suspending agent, a dispersible oil suspending agent, a suspoemulsion, a microcapsule suspension-suspending agent, a microcapsule suspension-aqueous emulsion or a microcapsule suspension-suspoemulsion;
preferably, the liquid preparation is selected from suspending agents, and the solid preparation is selected from water dispersible granules or wettable powder.
7. Use of the insecticidal and acaricidal composition according to claims 1 to 6 for controlling plant pests and/or acarids.
8. Use according to claim 7, characterized in that the plant pests are pests of the family psyllidae; the plant pest mites are spider mite mites.
9. The use according to claim 8, wherein the psyllidae pests are psyllids pyricularis, psyllids citri or morinda citri, and the tetranychidae pests are tetranychus cinnabarinus, tetranychus urticae, tetranychus truncatus and/or panonychus citri;
preferably, the pest of the psyllidae is diaphorina citri, and the pest of the tetranychidae is tetranychus cinnabarinus.
10. Use according to claim 8, characterized in that the insecticidal and acaricidal composition and/or the formulation thereof is applied to the pests and/or mites or to their growth medium.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016174052A1 (en) * | 2015-04-30 | 2016-11-03 | Bayer Animal Health Gmbh | Antiparasitic combinations |
| EP3586630A1 (en) * | 2018-06-28 | 2020-01-01 | Bayer AG | Active compound combinations having insecticidal/acaricidal properties |
| JP2022021624A (en) * | 2020-07-22 | 2022-02-03 | 日本農薬株式会社 | Pest control composition and application method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016174052A1 (en) * | 2015-04-30 | 2016-11-03 | Bayer Animal Health Gmbh | Antiparasitic combinations |
| EP3586630A1 (en) * | 2018-06-28 | 2020-01-01 | Bayer AG | Active compound combinations having insecticidal/acaricidal properties |
| JP2022021624A (en) * | 2020-07-22 | 2022-02-03 | 日本農薬株式会社 | Pest control composition and application method thereof |
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