CN115837120A

CN115837120A - Electrode patch, manufacturing method of electrode patch and tumor electric field therapeutic apparatus

Info

Publication number: CN115837120A
Application number: CN202211678871.XA
Authority: CN
Inventors: 陈晟; 沈琪超
Original assignee: Jiangsu Hailai Xinchuang Medical Technology Co Ltd
Current assignee: Jiangsu Hailai Xinchuang Medical Technology Co Ltd
Priority date: 2022-12-26
Filing date: 2022-12-26
Publication date: 2023-03-24
Anticipated expiration: 2042-12-26
Also published as: CN117899353A; CN115837120B

Abstract

The invention provides an electrode patch for tumor electric field treatment, which comprises at least one electrode unit, an adapter plate detachably connected with the at least one electrode unit and a backing adhered to the at least one electrode unit and the corresponding part of the adapter plate. The electrode patch is formed by detachably connecting at least one electrode unit and the adapter plate, so that the failed electrode unit on the electrode patch can be detachably replaced, or the failed adapter plate on the electrode patch can be detachably replaced, the loss of the whole electrode patch is reduced, and the yield loss of the electrode patch is reduced.

Description

Electrode patch, manufacturing method of electrode patch and tumor electric field therapeutic apparatus

Technical Field

The application relates to an electrode patch, a manufacturing method of the electrode patch and a tumor electric field therapeutic apparatus, and belongs to the technical field of medical instruments.

Background

At present, the treatment modes of tumors mainly comprise operations, radiotherapy, chemotherapy and the like, but the methods have corresponding defects, for example, radiotherapy and chemotherapy can generate side effects and kill normal cells. The electric field treatment of tumor is one of the current development fronts, and the tumor electric field treatment generates a tumor treatment method which interferes the mitosis process of tumor cells through a low-intensity, medium-high frequency and alternating electric field by a special electric field generator. Research shows that the electric field treatment has obvious effect in treating diseases such as glioblastoma, non-small cell lung cancer, malignant pleural mesothelioma and the like, and the electric field applied by the treatment method can influence the aggregation of tubulin, prevent spindle formation, inhibit mitosis process and induce cancer cell apoptosis.

The electric field tumor treating instrument for treating tumor includes mainly electric field generator and electrode patches connected electrically to the electric field generator, and the electrode patches are applied to the skin of human body in pairs for applying alternating electric field to the focus of human body to treat tumor. Each electrode patch includes a flexible circuit board, a plurality of ceramic sheets disposed on the flexible circuit board at intervals, and a lead electrically connected to the flexible circuit board, as disclosed in chinese patent publication No. 11271272 or No. 113164745. The flexible circuit board comprises a flexible board substrate, a plurality of paths of conductive traces embedded in the flexible board substrate and a plurality of conductive bonding pads exposed on the flexible board substrate and electrically connected by the same conductive trace. The ceramic plates are arranged on the flexible circuit board by being welded with the corresponding conductive discs and are connected in series through a conductive trace electrically connected with all the conductive discs. One end of the lead is electrically connected with the flexible circuit board, and the other end of the lead is provided with a plug which can be inserted with the electric field generator.

Because the ceramic plates are made of hard materials and the flexible circuit board is made of flexible materials, the flexible circuit board of the electrode patch of the tumor electric field treatment system has stronger mechanical strength at the positions where the ceramic plates are arranged at intervals than at the positions where the ceramic plates are not arranged, and the flexible circuit board is easy to be arranged at the positions where the ceramic plates are arranged and at the positions where the ceramic plates are not arranged

There is a risk of buckling at the joints where the ceramic sheets are placed, and if the buckling is severe, there is a risk of breaking the conductive traces in the substrate of the flexible board 5. The plurality of ceramic plates of the electrode patch are connected in series through the same conductive trace of the flexible circuit board, so that the problems that an electric signal cannot be transmitted to all the ceramic plates due to the breakage of the conductive trace of the flexible circuit board, the electrode patch is integrally scrapped and cannot be used and reused due to unqualified detection during manufacturing, the manufacturing yield of products is low, and the manufacturing cost is increased exist.

Therefore, there is a need to provide an improved electrode patch and an improved tumor electric field therapy apparatus, which solve the above technical problems of the electrode patch of the tumor electric field therapy apparatus.

Disclosure of Invention

The invention provides an electrode patch capable of avoiding scrapping of the whole electrode patch, a manufacturing method of the electrode patch 5 and a tumor electric field therapeutic apparatus.

Aiming at the problems in the prior art, the electrode patch provided by the invention is realized by the following technical scheme: an electrode patch for tumor electric field therapy comprises at least one electrode unit, an adapter plate detachably connected with at least one electrode unit, and a backing adhered to at least one electrode unit and the corresponding part of the adapter plate.

And 0 further, each electrode unit comprises a flexible board substrate, support plates and ceramic transduction pieces which are arranged on two sides of the flexible board substrate respectively, and a male seat arranged on the same side surface of the ceramic transduction piece on the flexible board substrate.

Furthermore, the ceramic energy conversion piece and the male seat are respectively located at two opposite ends of the flexible board substrate, and the ceramic energy conversion piece and the supporting plate are located at the same end of the flexible board substrate.

5 further, the electrode unit further comprises a flexible plate substrate and a ceramic electrode unit arranged on the flexible plate substrate

The energy pieces are positioned on the temperature sensors on the same side.

Furthermore, the ceramic transduction piece is provided with a through opening, and the temperature sensor is accommodated in the through opening of the ceramic transduction piece.

Furthermore, the adapter plate is provided with at least one female seat which corresponds to and is electrically connected with the male seat of the electrode unit, and the female seat of the adapter plate is detachably connected with the male seat of the electrode unit.

Furthermore, the adapter plate comprises a body and a wiring part connected with the body, at least one female base of the adapter plate is arranged on the body, and the wiring part is located at one end of the body.

Further, the body has a trunk, and the at least one female seat is located on the trunk.

Further, the trunk of body is equipped with at least one fretwork hole that runs through the form and set up, the fretwork hole corresponds the setting with corresponding female seat.

Furthermore, the hollow hole allows the corresponding ceramic transduction piece of the electrode unit to pass through, and the ceramic transduction piece of the electrode unit is exposed to one side of the adapter plate far away from the female seat when the electrode unit is arranged on the adapter plate.

Further, the body still includes a plurality of branches that are located the trunk both sides, be equipped with on the branch the female seat.

Furthermore, an interval allowing the ceramic transduction piece of the corresponding electrode unit to pass through is formed between two adjacent branches on the same side of the trunk, and the ceramic transduction piece of the electrode unit is exposed on one side of the connecting plate away from the female seat after passing through the interval.

Further, the electrode patch further comprises a wire electrically connected with the wiring portion of the adapter plate, one end of the wire is electrically connected with the wiring portion of the adapter plate, and a plug is arranged at the other end of the wire.

Furthermore, a circle of heat-shrinkable sleeve is further wrapped on the periphery of the connection part of the lead and the wiring part.

Furthermore, a plug of the lead is detachably inserted with a transfer line.

Further, the backing is arranged in a sheet shape and provided with at least one through hole which corresponds to the electrode unit and is arranged in a penetrating manner, and the through hole of the backing allows the corresponding part of the electrode unit to be exposed out of one side surface of the backing far away from the adapter plate.

Furthermore, the electrode patch also comprises a support piece which is arranged around the corresponding part of the electrode unit and is adhered to the back lining, and an adhesive piece which covers the support piece and the corresponding part of the electrode unit and is adhered to the body surface skin corresponding to the tumor part of the patient.

Further, the support piece is provided with at least one through hole in a penetrating manner.

Further, the through holes include first through holes corresponding to the respective electrode units and receiving respective portions of the respective electrode units.

Further, the through holes further include a second through hole located between the plurality of first through holes and opposite to the interposer.

Furthermore, the electrode patch also comprises at least one release paper which is positioned on one side of the adhesive part, which is far away from the back lining, and covers the adhesive part and the back lining.

The invention also provides a manufacturing method of the electrode patch, which is realized by the following technical scheme: a method of manufacturing an electrode patch, comprising the steps of:

s11, providing an adapter plate, wherein the adapter plate is provided with at least one group of third bonding pads and a wiring part;

s12, providing at least one female seat, and respectively welding the female seats on corresponding third bonding pads of the adapter plate;

s13, providing a lead, and arranging the lead at the wiring part of the adapter plate in a combined manner;

s14, providing a heat-shrinkable sleeve, and coating the heat-shrinkable sleeve at the joint of the adapter plate and the lead;

s15, providing at least one electrode unit detachably connected with the adapter plate, and clamping the electrode unit with the female seat on the adapter plate;

and S16, providing a backing, and adhering the corresponding part of the surface of one side of the adapter plate provided with the female seat and the surface of the electrode unit on the same side, which are subjected to the steps, on the backing.

Further, after the step S16, the following steps are also included:

s17, providing a supporting piece, and adhering the supporting piece on the backing in a shape surrounding the corresponding part of the electrode unit;

s18, providing an adhesive piece, and adhering the adhesive piece to one side surface of the corresponding part of the support piece and the electrode unit, which is far away from the back lining;

s19, providing release paper, and covering the release paper on the surface of the back lining and the adhesive piece close to the skin of the patient.

Further, the manufacturing method of the electrode unit includes the steps of:

s21, providing a flexible board substrate, wherein one end of the flexible board substrate is provided with a plurality of conducting discs arranged at intervals and two first bonding pads located in the surrounding area of the conducting discs, and the other end of the flexible board substrate is provided with a plurality of second bonding pads;

s22, providing a support plate, and respectively arranging the support plate on the flexible plate substrate in a one-to-one correspondence manner with the plurality of conductive discs, wherein the support plate and the conductive discs are respectively positioned at two opposite sides of the flexible plate substrate;

s23, providing a temperature sensor, and welding the temperature sensor on the two first bonding pads;

s24, providing a ceramic energy conversion sheet with an opening, and welding the ceramic energy conversion sheet on the plurality of conductive discs in a mode that the corresponding temperature sensors are accommodated in the opening;

and S25, providing a male seat, and welding the male seat on the second bonding pads.

The tumor electric field therapeutic apparatus provided by the invention is realized by the following technical scheme: an electric field therapeutic apparatus for treating tumor is composed of an electric field generator and at least one pair of said electrode patches electrically connected to said electric field generator.

Further, the electrode patch comprises an adapter which is electrically connected between the electrode patch and the electric field generator.

The electrode patch of the tumor electric field therapeutic apparatus is formed by detachably connecting at least one electrode unit and the adapter plate, so that the failed electrode unit on the electrode patch can be detachably replaced, or the failed adapter plate on the electrode patch can be detachably replaced, the replacement of the whole electrode patch is avoided, and the yield loss of the electrode patch is reduced.

Drawings

FIG. 1 is a schematic view of an electrode patch of an E-field tumor therapy device according to a first embodiment of the present invention;

FIG. 2A is an exploded view of the electrode unit of FIG. 1;

FIG. 2B is a schematic diagram of the electrode unit of FIG. 1;

FIG. 3 is a wiring diagram of the flexible board substrate of the electrode unit in FIG. 2A;

FIG. 4 is a schematic structural diagram of the interposer of FIG. 1;

FIG. 5A is a front wiring diagram of the interposer of FIG. 4;

FIG. 5B is a reverse wiring diagram of the interposer of FIG. 4;

fig. 6A is a schematic view of the electrode patch of fig. 1, wherein the supporting member and the adhesive member are not shown;

fig. 6B is another schematic view of the electrode patch of fig. 1, wherein the supporting member and the adhesive member are not shown;

FIG. 7 is a schematic view of the combination of the electrode unit, interposer, lead, backing and support of FIG. 1;

FIG. 8A is a schematic overall view of the electrode patch of FIG. 1;

FIG. 8B is a schematic view of the electrode patch of FIG. 1 taken from another perspective;

FIG. 9A is an exploded view of an electrode patch of the electric field therapy apparatus for tumor according to the second embodiment of the present invention, wherein the release liner is not shown;

fig. 9B is an assembled schematic view of the electrode patch shown in fig. 9A, wherein the release paper is not shown;

fig. 10A is an exploded view of the interposer and the conductive wires of fig. 9A;

FIG. 10B is a schematic view of the interposer and the conductive wire assembly shown in FIG. 10A;

FIG. 11A is a front wiring diagram of the interposer of FIG. 10A;

FIG. 11B is a reverse wiring diagram of the interposer of FIG. 10A;

FIG. 12 is a flow chart illustrating a method for manufacturing an electrode patch of the electric field tumor therapy apparatus according to the present invention;

fig. 13 is a flowchart illustrating a method of manufacturing an electrode unit of the electrode patch shown in fig. 12.

Detailed Description

Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus, devices, systems, and methods consistent with certain aspects of the application, as detailed in the claims that follow.

The tumor electric field treatment apparatus (not shown) of the present invention comprises an electric field generator (not shown) and electrode patches 100, 100' connected to the electric field generator (not shown). The electrode patches 100 and 100' are applied to the skin surface of a human body, and a therapeutic electric field generated by an electric field generator (not shown) is applied to the human body to perform electric field therapy of tumors. The electrode patch 100, 100' of the embodiment of the present application is applied to the head of a human body for use in the adjuvant therapy of brain tumors, such as glioblastoma multiforme. In other embodiments, an adapter (not shown) may be disposed between the electrode patches 100, 100' and the electric field generator (not shown) of the tumor E-field therapy device (not shown). An adapter (not shown) is electrically connected between the electrode patches 100, 100' and the electric field generator (not shown).

Fig. 1 to 8 show an electrode patch 100 according to a first embodiment of the present invention. The electrode patch 100 can be directly connected to an electric field generator (not shown) to realize an electrical connection with the electric field generator (not shown), or can be directly connected to an adapter (not shown) to realize an electrical connection with the electric field generator (not shown) through the adapter (not shown). The electrode patch 100 includes at least one electrode unit 10, an interposer 20 detachably connected to the at least one electrode unit 10, a lead 30 electrically connected to the interposer 20, a backing 40 attached to corresponding portions of the electrode unit 10 and the interposer 20, a support member 50 disposed around the corresponding portions of the electrode unit 10 and attached to the backing 40, and an adhesive member 60 covering the support member 50 and the corresponding portions of the electrode unit 10 and attached to a body surface skin of a patient corresponding to a tumor site. The electrode patch 100 is attached to the body surface of a patient corresponding to a tumor region through the backing 40, and applies an alternating electric field to the tumor region of the patient through at least one electrode unit 10 detachably connected to the adapter plate 20 to interfere or prevent mitosis of tumor cells of the patient, thereby achieving the purpose of treating tumors. According to the invention, the electrode patch 100 is formed by detachably connecting at least one electrode unit 10 and the adapter plate 20, so that the failed electrode unit 10 can be detachably replaced, or the failed adapter plate 20 can be detachably replaced, the loss of the whole electrode patch 100 can be reduced before the product is delivered, the yield loss of the electrode patch 100 is reduced, the whole electrode patch 100 can be prevented from being scrapped when the electrode patch 100 is used, and the cost is saved; the intensity of the alternating electric field applied by the electrode patch 100 can also be adaptively adjusted according to the size of the tumor by freely selecting the number of electrode units 10 plugged onto the adapter plate 20.

Referring to fig. 2A and 2B, each electrode unit 10 includes a flexible board substrate 11, a supporting plate 13 and a ceramic transducer 12 respectively disposed on two sides of the flexible board substrate 11, and a male seat 15 disposed on the same side surface of the ceramic transducer 12 of the flexible board substrate 11. The ceramic transducer 12 and the male seat 15 are respectively located at two opposite ends of the flexible board substrate 11, and the ceramic transducer 12 and the supporting board 13 are located at the same end of the flexible board substrate 11. In this embodiment, the sizes of the supporting plate 13 and the ceramic transducer 12 are slightly smaller than the size of the flexible plate substrate 11.

The ceramic transducer 12 is made of a high dielectric constant material, has the conductive characteristics of blocking the conduction of direct current and allowing the passage of alternating current, and can ensure the safety of a user during tumor electric field treatment. The ceramic transducer plate 12 has an opening 121 formed through the center thereof. The electrode unit 10 further comprises a temperature sensor 14 arranged on the flexible board substrate 11 and located on the same side as the ceramic transducer plate 12. The temperature sensor 14 is received in an opening 121 in the center of the ceramic transducer 12 for sensing the temperature of the patient's skin against which the electrode patch 100 is applied. The temperature sensor 14 has a ground terminal 14A and a signal terminal 14B. Preferably, the temperature sensor 14 is a thermistor.

Referring to fig. 3, three first conductive traces 114 are embedded in the flexible board substrate 11. The three first conductive traces 114 include a first ground line 114A electrically connected to the ground terminal 14A and the male socket 15 of the temperature sensor 14, a first signal line 114B electrically connected to the signal terminal 14B and the male socket 15 of the temperature sensor 14 for transmitting a temperature signal, and a first AC line 114C annularly disposed and electrically connected to the ceramic transducer 12 and the male socket 15. The first ground line 114A and the first signal line 114B are both disposed along the length direction of the flexible board substrate 11. The first AC line 114C is disposed in a closed loop along the periphery of the flexible board substrate 11, and includes a first AC line segment 115 located at the same end as the ceramic transducer 12 and disposed in an arc shape, and a second AC line segment 116 extending from the first AC line segment 115 and disposed in an inverted "pi" shape. The first AC line segment 115 is electrically connected to the ceramic transducer 12 disposed on the flexible board substrate 11. One end of the second AC line segment 116 is connected to both opposite ends of the first AC line segment 115, and the other end is connected to the male socket 15 disposed on the flexible board substrate 11 by welding. The electrode unit 10 is electrically connected to the first AC line segment 115 of the first AC line 114C of the flexible board substrate 11 through the ceramic transducer 12, the first AC line segment 115 of the first AC line 114C of the flexible board substrate 11 is connected to one end of the second AC line segment 116, and the other end of the second AC line segment 116 of the first AC line 114C of the flexible board substrate 11 is electrically connected to the male base 15, so as to achieve the electrical connection between the ceramic transducer 12 and the male base 15.

The second AC line segment 116 is closed at an end portion away from the first AC line segment 115 after opposite ends of the first AC line segment 115 extend along the length direction of the flexible board substrate 11. The second AC line segment 116 extends from one end of the first AC line segment 115 in a direction away from the ceramic transducer 12, then bends and extends toward the other end of the first AC line segment 115, and then extends toward the other end of the first AC line segment 115 until being connected to the other end of the first AC line segment 115. The second AC line segment 116 includes a portion extending from one end of the first AC line segment 115 and configured in an "L" shape and a portion extending from the other end of the first AC line segment 115 and configured in an "I" shape. The second AC line segment 116 has two parts respectively connected to two opposite ends of the first AC line segment 115, and when one of the two parts is disconnected from one end of the first AC line segment 115 due to bending, the other part is connected to the other end of the first AC line segment 115, so as to ensure the electrical connection between the second AC line segment and the first AC line segment 115, thereby achieving a good and stable electrical connection between the ceramic transducer 12 and the male housing 15. That is, the second AC line segment 116 of the first AC line 114C is connected to both opposite ends of the circular arc-shaped first AC line segment 115,

even when the second AC line segment 116 and the first AC line segment 115 are broken by bending, the electrical signal can still be transmitted to the ceramic transducer 12 through the connection between the second AC line segment 116 and the other end of the first AC line segment 115, so as to ensure the reliability of the electrical connection between the ceramic transducer 12 of the electrode unit 10 and the flexible board substrate 11, improve the product quality, and reduce the product defect rate. The first ground line 114A and the first signal line 114B are both located in the area encircled by the first AC line 114C, so as to facilitate wiring and reduce wiring difficulty.

The same side surface of the flexible board substrate 11 of 0 is further provided with a plurality of conductive pads 111 which are arranged at intervals and welded with the ceramic transducer 12, two first pads 112 which are respectively welded with the grounding terminal 14A and the signal terminal 14B of the temperature sensor 14, and a plurality of second pads 113 which are welded with the male socket 15. Conductive plate 111 and

the first bonding pads 112 are located at the same end of the flexible board substrate 11, and the second bonding pads 113 are located at the other end of the flexible board substrate 11. The plurality of conductive pads 111 are electrically connected to the first AC line segment 115 of the first AC line 5 114C embedded in the flexible board substrate 11, and are connected in series through the arc-shaped first AC line segment 115. The flexible board substrate 11 is electrically connected to the conductive pad 111 through the first AC line segment 115 of the first AC line 114C, and the conductive pad 111 is welded to the ceramic transducer 12 to electrically connect to the ceramic transducer 12.

The two first pads 112 are located at the middle position surrounded by the plurality of conductive pads 111. The first pad 112 bonded to the ground terminal 14A of the temperature sensor 0 14 is a first pad 112A, and the first pad 112 bonded to the signal terminal 14B of the temperature sensor 14 is a first pad 112B. The first pad 112A is disposed at the end of the first ground line 114A within the first AC segment 115 of the first AC line 114C, and the first pad 112B is disposed at the end of the first signal line 114B within the first AC segment 115 of the first AC line 114C

Of the end of (c). The first pad 112A is electrically connected to one end of the first ground line 114A, and the first pad 5 112B is electrically connected to one end of the first signal line 114B. The flexible board substrate 11 is electrically connected to the temperature sensor 14 by soldering the ground terminal 14A of the temperature sensor 14 to the first bonding pad 112A connected to the first ground line 114A and soldering the signal terminal 14B of the temperature sensor 14 to the first bonding pad 112B connected to the first signal line 114B.

The second bonding pad 113 and the first bonding pad 112 are respectively disposed at two opposite ends of the flexible board substrate 11. The second bonding pad 113 is disposed at an end of the flexible board substrate 11 away from the ceramic transducer 12 and is welded to the male socket 15, so as to electrically connect the male socket 15 to the second bonding pad. The number of the second pads 113 is at least 3, and includes a second pad 113A electrically connected to the first pad 112A through a first ground line 114A, a second pad 113B electrically connected to the first pad 112B through a first signal line 114B, and at least one second pad 113C electrically connected to the conductive pad 111 through a first AC line 114. The second pad 113A and the first pad 112A are respectively disposed at two opposite ends of the first ground line 114A, and are electrically connected to each other through the first ground line 114A. The second bonding pad 113B and the first bonding pad 112B are respectively disposed at two opposite ends of the first signal line 114B, and electrically connected to each other through the first signal line 114B. The second pad 113C and the conductive pad 111 are respectively disposed at two opposite ends of the first AC line 114, and are electrically connected to each other through the first AC line 114. The second pad 113C is provided at the end of the second AC line segment 116 of the first AC line 114, and the conductive pad 111 is provided on the first line segment 115 of the first AC line 114. The flexible board substrate 11 is welded to the ceramic transduction piece 12 through the conductive plate 111 disposed on the first AC line segment 115 of the first AC line 114C, and the second pad 113C disposed at the end of the second line segment 116 of the first AC line 114C is welded to the male socket 15, so as to achieve electrical connection between the male socket 15 and the ceramic transduction piece 12. The flexible board substrate 11 is welded to the ground terminal 14A of the temperature sensor 14 through a first bonding pad 112A disposed at one end of the first ground line 114A, a first bonding pad 112B disposed at one end of the first signal line 114B is welded to the signal terminal 14B of the temperature sensor 14, a second bonding pad 113A disposed at the other end of the first ground line 114A, and a second bonding pad 113B disposed at the other end of the first signal line 114B are welded to the male socket 15, so that the temperature sensor 14 and the male socket 15 are electrically connected.

The number of the second bonding pads 113 welded to the male base 15 is at least three, so that the male base 15 and the flexible board substrate 11 can be welded firmly when the male base 15 is welded to the flexible board substrate 11 through the second bonding pads 113, and good electrical connection between the male base 15 and the flexible board substrate 11 is ensured. And the conductive disc 111 is welded with the male socket 15 through at least one second welding pad 113C arranged on the second AC line segment 116 of the first AC line 114C, so that stable electrical connection between the conductive disc 111 and the male socket 15 can be ensured, and an electrical signal for tumor treatment is transmitted to the conductive disc 111 through the first AC line 114C and then transmitted to the ceramic transducer 12 through the conductive disc 111. In this embodiment, the four second pads 113C soldered to the male socket 15 are connected to the second AC line segments 116 of the first AC line 114C, respectively. Other embodiments are possible for the purpose of reinforcing the degree of weld securement of the male base 15 to the flexible board substrate 11. For example, one of the second pads 113 is connected to the first ground line 114A, one of the second AC line segments 116 is connected to the first AC line 114C, and the rest of the second pads are connected to the corresponding first signal lines 114B in a one-to-one correspondence. For another example, one of the second pads 113 is connected to the first signal line 114B, one is connected to the first AC line 114C, and the rest are connected to the first ground line 114A, respectively. That is, two of the plurality of second pads 113 are connected to two lines of the first ground line 114A, the first signal line 114B, and the first AC line 114C, respectively, and the remaining second pads 113 are connected to the remaining one line of the first ground line 114A, the first signal line 114B, and the first AC line 114C, respectively.

The ground signal of the temperature sensor 14 is transmitted to the corresponding second pad 113A electrically connected to the first ground line 114A through the first ground line 114A electrically connected to the ground terminal 14A; the temperature signal detected by the temperature sensor 14 is transmitted to the corresponding second pad 113B electrically connected to the first signal line 114B through the first signal line 114B electrically connected to the signal terminal 14B thereof; the second bonding pad 113 is welded with the male seat 15, the male seat 15 is connected with the adapter plate 20 in an inserting mode, the adapter plate 20 is electrically connected with the lead 30, the lead 30 is connected with an electric field generator (not shown) in an inserting mode, and a temperature signal detected by the temperature sensor 14 is transmitted to the electric field generator (not shown), so that the purpose that the electric field generator (not shown) controls an alternating electric signal transmitted to the ceramic transducer 12 through the detected temperature signal, and the low-temperature scald of the surface of the tumor body of a patient caused by overhigh temperature is avoided. The AC signal generated by the electric field generator (not shown) is transmitted to the first AC line 114C disposed annularly through the corresponding at least two second pads 113C, and then transmitted to the ceramic transducer plate 12 through the plurality of conductive pads 111 welded to the first AC line 114C, so as to apply the AC electric signal to the tumor site for tumor electric field therapy. The AC signal required for the ceramic transducer 12 is an alternating current signal, which is output by an electric field generator (not shown). The electric field generator (not shown) also outputs a dc signal to the temperature sensor 14, which causes the temperature sensor 14 to turn on the ground signal and operate to generate a temperature signal.

The support plate 13 is adhered to a surface of the flexible board substrate 11 on a side away from the conductive pad 111 by an adhesive (not shown). The support plates 13 correspond to the ceramic transducer pieces 12 one by one in the thickness direction. The temperature sensor 14 is welded at a position of the flexible board substrate corresponding to the two first bonding pads 112, the ceramic energy conversion sheet 12 is welded at a position of the flexible board substrate 11 corresponding to the plurality of conductive plates 111, and the male seat 15 is welded at a position of the second bonding pad 113 of the flexible board substrate 11. The temperature sensor 14, the ceramic transducer 12 and the support plate 13 are all disposed at the same end of the flexible board substrate 11. When the temperature sensor 14 and the ceramic transduction piece 12 are welded, the support plate 13 provides strength support for the flexible board substrate 11, and provides a smooth welding plane for the welding operation between the flexible board substrate 11 and the temperature sensor 14 and between the flexible board substrate and the ceramic transduction piece 12, so that the product yield is improved. The flexible board substrate 11 is provided with a reinforcing plate 16 adhered to one end of the welding male seat 15, the reinforcing plate 16 is disposed on a surface of the flexible board substrate 11 opposite to the male seat 15 to provide strength support for the flexible board substrate 11, so as to weld the male seat 15 to the flexible board substrate, and simultaneously, the male seat 15 of the electrode unit 10 is prevented from bending at the welding position of the flexible board substrate 11 and the male seat 15 when being inserted into or pulled out from the adapter plate 20, so that the embedded conductive trace inside the flexible board substrate 11 is broken. The reinforcing plate 16 and the male seat 15 are respectively disposed on two opposite sides of the flexible board substrate 11. The stiffening plate 16 is located at the same end of the flexible plate substrate 11 as the male socket 15.

The adapter plate 20 is provided with at least one female seat 25 corresponding to and electrically connected to the male seat 15 of the electrode unit 10. The plurality of electrode units 10 can be respectively spliced and combined with the corresponding female seat 25 on the adapter plate 20 through the corresponding male seat 15 to form the electrode patch 100 with at least one electrode unit 10, and by means of the detachable combination of the electrode units 10 and the adapter plate 20, the failed electrode units 10 can be detachably replaced, or the failed adapter plate 20 can be detachably replaced, so that the whole electrode patch 100 is prevented from being scrapped, and the yield loss of the electrode patch 100 is reduced; the whole electrode patch 100 is prevented from being scrapped, waste is avoided, and the cost is reduced; meanwhile, the number of the electrode units 10 inserted into the adapter plate 20 can be freely combined and selected, so that the electric field intensity generated by the electrode patch 100 can be increased or reduced, and the electric field intensity of the tumor part of the patient generated by the electrode patch 100 can be ensured.

The interposer 20 is a sheet-like structure having a body 28 for inserting and combining at least one electrode unit 10 and a connecting portion 27 for electrically connecting a lead 30. The wire connection portion 27 is provided integrally with the body 28. The wire connection portion 27 is located at one side end of the body 28. The female socket 25 to be inserted into the male socket 15 of the electrode unit 10 is provided on the body 28 by welding. The wires 30 are electrically connected to the interposer 20 by being soldered to the wiring portions 27. The electrode unit 10 of the electrode patch 100 is electrically connected to the interposer 20 by inserting the male socket 15 into the female socket 25 welded to the interposer 20, and the interposer 20 is electrically connected to the lead 30 by welding the connection portion 27 thereof to the lead 30. The electrode unit 10 of the electrode patch 100 is electrically connected to the lead 30 via the interposer 20. Preferably, the interposer 20 is a flexible circuit board. Preferably, the plurality of electrode units 10 are all connected to the interposer 20 in parallel, and even if the electrical connection between one electrode unit 10 and the interposer 20 is interrupted, the electrical connection between the other electrode units 10 and the interposer 20 is not affected.

Referring to fig. 5A and 5B, the interposer 20 has at least one set of third pads 23 disposed on the body 28 and soldered to the corresponding female sockets 25, and a plurality of fourth pads 24 disposed on opposite sides of the wire connecting portion 27 and soldered to the wires 30. The configuration of each set of third pads 23 is the same as the configuration of the second pads 113 of the electrode unit 10, each set of third pads 23 has a plurality of third pads 23, one third pad 23A of the plurality of third pads 23 connects a ground signal, one third pad 23B and a temperature signal, and the remaining third pads 23C are all connected to an AC signal. A group of the fourth pads 24 has a plurality of fourth pads 24. The plurality of fourth pads 24 includes a fourth pad 24A transmitting a ground signal, a fourth pad 24C transmitting an AC signal, and a plurality of fourth pads 24B each transmitting a corresponding temperature signal. The third pads 23A of the plurality of sets of third pads 23 transmitting the ground signal are all connected in parallel to one fourth pad 24A, the third pads 23C of the plurality of sets of third pads 23 transmitting the AC signal are all connected in parallel to one fourth pad 24C, and the third pads 23B of the plurality of sets of third pads 23 transmitting the temperature signal are all connected in parallel to the corresponding fourth pads 24B.

Multiple second conductive traces 26 are embedded within the interposer 20. The sets of third pads 23 and

fourth pads

24A, 24B, and 24C are respectively disposed at two opposite ends of the plurality of second conductive traces 26, and electrically connected to each other through the second conductive traces 26. The multiple groups of third pads 23 are arranged at one end of the multiple paths of second conductive traces 26 in a parallel connection manner, and the multiple electrode units 10 can be connected to the adapter plate 20 in parallel after the multiple electrode units 10 are respectively plugged into the female seats 25 welded with the multiple groups of third pads 23 through the corresponding male seats 15, so that signal transmission between each electrode unit 10 and the adapter plate 20 is independent and does not influence each other, and even if one electrode unit 10 is damaged, signal transmission between the other electrode units 10 and the adapter plate 20 is not influenced, normal work of the other electrode units 10 is ensured, and the whole electrode patch 100 does not need to be replaced or scrapped.

The multiplexed second conductive trace 26 includes a second ground line 26A that transmits a ground signal, a second AC line 26C that transmits an AC signal, and second signal lines 26B that respectively transmit corresponding temperature signals. The second AC line 26C transmits an AC signal, is arranged in a dendritic wiring, and is electrically connected to one third pad 23C connected to the AC signal in each group of third pads 23 and one fourth pad 24C connected to the AC signal in each group of fourth pads 24, so that each electrode unit 10 assembled with the female socket 25 corresponding to the corresponding third pad 23 can be in an equipotential state, and the stability of the AC signal of the electrode patch 100 is ensured. One third pad 23C connected with the AC signal in each group of third pads 23 is connected to the second AC line 26C in parallel, that is, the on/off of the AC signal of each electrode unit 10 assembled with the female socket 25 corresponding to the corresponding third pad 23 is not affected. Even in the using process, the damage of the electrode unit 10 does not influence other electrode units 10 to continuously apply the alternating electric field to the tumor part of the patient for tumor electric field treatment. The second ground line 26A transmits a ground signal, is provided in a tree-like wiring, and is electrically connected to one third pad 23A connected to the ground signal in each group of the third pads 23 and one fourth pad 24A connected to the ground signal in each group of the fourth pads 24. One third pad 23A of each group of third pads 23 connected to the ground signal is connected to the second ground line 26A in parallel, that is, the on/off of the ground signal of each electrode unit 10 assembled in the mother socket 25 corresponding to the corresponding third pad 23 is not affected. The multiple second signal lines 26B transmit corresponding temperature signals respectively, and are electrically connected to one third pad 23B connected with a temperature signal in a corresponding group of third pads 23 and one corresponding fourth pad 24B connected with a temperature signal in the group of fourth pads 24 in a one-to-one correspondence manner. By the connection relationship among the third pads 23, the fourth pads 24 and the multiple second conductive traces 26, at least one group of the third pads 23 are connected in parallel, so that at least one electrode unit 10 is connected to the interposer 20 in parallel, and the on/off of the AC signal, the ground signal and the temperature signal of each electrode unit 10 are not affected by each other.

That is, the plurality of third pads 23C are connected to the second AC line 26C in parallel. The plurality of third pads 23A are also connected to the second ground line 26A in parallel. The plurality of third pads 23B are respectively connected to a corresponding one of the signal lines 26B, and are connected to the corresponding fourth pads 24B through a corresponding one of the signal lines 26B. Each female seat 25 is welded with the corresponding group of third pads 23 and arranged on the adapter plate 20 in parallel, so that each electrode unit 10 can be connected to the adapter plate 20 in parallel after each electrode unit 10 is plugged into the corresponding female seat 25 through the corresponding male seat 15, and the on-off of signals between each electrode unit 10 and the adapter plate 20 is not affected, and even if one electrode unit 10 is damaged or electrically connected with the adapter plate 20, the electrical connection and the signal transmission between the other electrode units 10 and the adapter plate 20 are not affected.

The plurality of third pads 23A for transmitting the ground signal and the fourth pad 24A for transmitting the ground signal are respectively disposed at two opposite ends of one path of the second ground line 26A, and the corresponding third pads 23A and the fourth pads 24A are electrically connected through the path of the second ground line 26A, and the plurality of third pads 23A are disposed at one end of the second ground line 26A in a parallel connection manner, so that the ground signal transmission of each electrode unit 10 is independent and does not affect each other after the plurality of electrode units 10 are plugged into the corresponding female sockets 25 of the interposer 20. One end of each second signal wire 26B for transmitting temperature signals is connected with a third bonding pad 23B for transmitting temperature signals, and the other end of each second signal wire is connected with a fourth bonding pad 24B for transmitting temperature signals and corresponding to the third bonding pad 23B, so as to transmit the temperature signals collected by the temperature sensors 14 of the electrode units 10, and the temperature signals between the electrode units 10 can be transmitted independently and mutually independently after the electrode units 10 are inserted into the adapter plate 20.

The plurality of third pads 23C for transmitting the AC signal and the one fourth pad 24C for transmitting the AC signal are respectively disposed at two opposite ends of one path of the second AC line 26C, and the corresponding third pads 23C and the fourth pads 24C are electrically connected by the one path of the second AC line 26C, and the plurality of third pads 23C are disposed at one end of the second AC line 26C in a parallel connection manner. The second AC line 26C for transmitting AC signals is a dendritic wiring, one end of which is electrically connected to one third pad 23C of each group of third pads 23, and the other end of which is electrically connected to one fourth pad 24C of the plurality of fourth pads 24, so that the AC signals of the electrode units 10 can be transmitted independently and without mutual influence after the electrode units 10 are plugged into the corresponding female sockets 25 of the interposer 20 through the corresponding male sockets 15.

In the present embodiment, the number of the fourth pads 24 is greater than the number of the second conductive traces 26, and the number of the

fourth pads

24A, 24B, and 24C electrically connected to the corresponding second conductive traces 26 is all conductive pads. The fourth bonding pad 24 further includes a dummy bonding pad 24D disconnected from the second conductive trace 26 for enhancing the bonding strength between the flexible interposer 20 and the conductive wire 30.

In this embodiment, the multiple second conductive traces 26 embedded in the interposer 20 are respectively disposed in two wiring layers to avoid the mutual interference between the multiple second conductive traces 26. In this embodiment, the second AC lines 26C are distributed in one layer, and the second ground lines 26A and the second signal lines 26B are distributed in two wiring layers to avoid the second AC lines 26C. In other embodiments, the multiple second conductive traces 26 embedded in the interposer 20 are respectively disposed in three or more layers, so as to improve the flexibility of routing the multiple second conductive traces 26.

As shown in fig. 4, 5A and 5B, in the present embodiment, the interposer 20 has a plurality of female sockets 25 to which the respective groups of third lands 23 are soldered. The plurality of female sockets 25 are welded to the body 28 at intervals. The body 28 of the adapter plate 20 also has a trunk 21 and at least one limb 22. The wiring portion 27 is located at one end of the trunk 21 of the body 28. The second conductive trace 26 of the interposer 20 is embedded in the trunk 21 and the branch 22 of the body 28. The female sockets 25 are welded to the trunk 21 and the at least one branch 22 at intervals, so that the female sockets 25 are in plug-in fit with the male sockets 15 of the electrode units 10 to assemble the electrode units 10 on the adapter plate 20 at intervals, and the electrode units 10 are electrically connected with the adapter plate 20.

In this embodiment, the trunk 21 of the body 28 of the adapter plate 20 is provided with at least one through-hole 211. The hollow hole 211 of the body 28 of the adapter plate 20 can allow the ceramic transducer 12 of the corresponding electrode unit 10 to pass through, so that the ceramic transducer 12 of the corresponding electrode unit 10 can be exposed to the side of the adapter plate 20 away from the female socket 25, and the ceramic transducer 12 of the corresponding electrode unit 10 can be configured on the skin surface of a human body through the adapter plate 20.

In this embodiment, the adapter plate 20 has 1 trunk 21 and 4 branches 22 extending from the trunk 21 to two sides, and two sides of the trunk 21 are respectively provided with 2 branches 22. The branches 22 at different sides of the trunk 21 are arranged in pairs. The two adjacent branches 22 on the same side of the trunk 21 have a space 221 therebetween for allowing the ceramic transducer 12 of the corresponding electrode unit 10 to pass through, so that the ceramic transducer 12 of the corresponding electrode unit 10 can be exposed to the side of the adapter plate 20 away from the female socket 25, and the ceramic transducer 12 of the corresponding electrode unit 10 can pass through the adapter plate 20 and be disposed on the skin surface of the human body.

In this embodiment, the adapter plate 20 is provided with 13 female sockets 25, and the 13 female sockets 25 are respectively disposed on 1 trunk 21 and 4 branches 22 of the body 28. The trunk 21 is provided with 3 female seats, two branches 22 close to the wiring portion 27 are respectively provided with 2 female seats, and the other two branches 22 are respectively provided with 3 female seats. Two hollow holes 211 are formed through the stem 21 to accommodate the corresponding 1 ceramic transducer of the electrode unit 10. The 3 female seats 25 on the trunk 21, the two hollow holes 211 on the trunk 21 and the wiring portion 27 are all arranged in an axisymmetric manner, and the symmetry axes of the three coincide with each other. As shown in fig. 4, the 3 female seats 25 on the trunk 21 are disposed in a longitudinal alignment with the two hollow holes 211 on the trunk 21. 2 of the 3 female sockets 25 on the trunk 21 are disposed on the same side of one hollow hole 211 far away from the wiring portion 27, and the other is disposed at a position between two hollow holes 211 of the trunk 21.

The 2 female sockets 25 provided on the branches 22 close to the wire connecting portion 27 are arranged on the corresponding branches 22 in an approximately "L" shape. The 3 mother seats 25 provided on the branch 22 far from the wiring portion 27 are arranged on the corresponding branch 22 in a pi shape with one end opened approximately, and the opening of the pi formed by the 3 mother seats 25 faces the trunk 21. The plurality of female seats 25 arranged on the branches 22 are all symmetrically arranged along the longitudinal symmetry axis of the trunk 21. 2 of the 5 female seats 25 on the two branches 22 located on the same side of the trunk 21 are respectively disposed at the end of the corresponding branch 22 in a longitudinally aligned manner, and the remaining 3 are respectively disposed at the positions of the corresponding branches 22 close to the trunk 21 in a longitudinally aligned manner. The 3 female seats 25 provided on the trunk 21 are arranged in a longitudinal alignment. Two liang of 4 female seats 25 that are located trunk 21 relative both sides and all are close to on the branch 22 of wiring portion 27 are the form setting of transversely aliging, specifically, locate respectively and be close to two female seats 25 that branch 22 tip of wiring portion 27 and be the form setting of transversely aliging, locate respectively and be close to on the two branches 22 of wiring portion 27 and be close to two female seats 25 of trunk 21 and also be the form setting of transversely aliging. Two female seats 25 which are arranged on the two branches 22 far away from the wiring portion 27 and are positioned at the end portions of the corresponding branches 22 are transversely aligned, 2 of the 4 female seats 25 which are arranged on the two branches 22 far away from the wiring portion 27 and are positioned at the positions, close to the trunk 21, of the corresponding branches 22 are transversely aligned, and the other 2 female seats are also transversely aligned.

In this embodiment, the female sockets 25 on the trunk 22 are uniformly distributed on the edge of the corresponding trunk 22, and the female sockets 25 on the trunk 21 and the corresponding female sockets 25 on the trunk 22 are respectively arranged in a horizontal alignment, so that the second conductive traces 26 of the interposer 20 are arranged in a wiring manner, and the female sockets 25 are arranged on the interposer in parallel connection through the second conductive traces 26. As shown in fig. 4 and 6B, the electrode units 10 detachably connected to the female sockets 25 at the ends of the branches 22 are transversely assembled to the adapter plate 20, and the electrode units 10 detachably combined to the female sockets 25 at the ends of the branches 22 are longitudinally assembled to the adapter plate 20. In other embodiments, since the electrode units 10 are connected to the interposer 20 in parallel, the on/off of the AC signal, the ground signal and the temperature signal of each electrode unit 10 are not affected, and the number of the electrode units 10 that are disassembled and assembled on the interposer 20 is less than the number of the female sockets 25 on the interposer 20.

Referring to fig. 4, 5A, 5B and 8A, one end of the wire 30 is electrically connected to the wiring portion 27 of the interposer 20, and the other end is provided with a plug 32. Preferably, the conductor 30 is a raymond head sheath wire. The wire 30 has a plurality of cores (not shown), each of which is soldered to the corresponding fourth pads 24 on both side surfaces of the wire connecting portion 27. In this embodiment, the number of the electrode units 10 of the electrode patch 100 is 13, and the number of the cores (not shown) of the lead 30 is 16. Accordingly, there are a core (not shown) of the wire 30 which is soldered to the

fourth pads

24A, 24B, 24C and a core (not shown) which is not soldered to the dummy pad 24D. The periphery of the welding position of the wire 30 and the wiring part 27 is further coated with a circle of heat-shrinkable sleeve 31 for sealing and insulating the welding position of the adapter plate 20 and the wire 30, so that the welding position of the adapter plate 20 and the wire 30 is prevented from being broken, and meanwhile, the dustproof and waterproof effects are achieved.

The conductive wire 30 further includes a shielding grid (not shown) covering and surrounding the plurality of wire cores (not shown). The fourth land 24 further includes a fourth land 24E at an end of the wire portion 27, which is soldered to a shielding grid (shown) of the wire 30 to shield the wire 30 from external signals interfering with signals transmitted by a plurality of cores (not shown) of the wire 30. The fourth pad 24E for shielding and the fourth pad 24A for transmitting a ground signal are connected to the second ground line 26A of the second conductive trace 26.

As shown in fig. 8A and 8B, a patch cord 33 may be further inserted into the plug 32 of the wire 30, and the patch cord 33 may be inserted into the electric field generator (not shown) to electrically connect the electric field generator (not shown), or may be inserted into an adaptor (not shown) through the patch cord 33, and then inserted into the electric field generator (not shown) to electrically connect the electric field generator (not shown). The adapter wire 33 is detachably connected to the lead wire 30, so that the distance from the lead wire 30 to the electric field generator (not shown) or the adapter (not shown) can be increased or shortened as required, and the lead wire 30 welded to the adapter plate 20 can be scrapped only when the electrode patch 100 is scrapped and needs to be replaced without scrapping the adapter wire 33, thereby reducing the cost and avoiding unnecessary waste. The number of cores (not shown) of the patch cord 33 is the same as the number of cores (not shown) of the lead 30, and they correspond to each other one by one. The patch cord 33 is a thunder double male sheathed cord.

The backing 40 is provided in a sheet shape having at least one through hole 41 corresponding to the electrode unit 10 and provided in a penetrating manner. The through holes 41 of the backing 40 may allow the corresponding portion of the electrode unit 10 to be exposed on the surface of the side thereof away from the interposer 20, which facilitates the dissipation of heat generated by the electrode patch 100 during the electric field treatment of tumors. In this embodiment, the support plate 13 of the electrode unit 10 passes through the through hole 41 of the backing 40 and exposes a side surface of the backing 40 away from the interposer 20. The size of the through-hole 41 of the backing 40 is slightly larger than that of the support plate 13.

The support member 50 is provided in a sheet shape and has a plurality of through holes 51 formed therethrough. The plurality of through holes 51 of the support member 50 include a plurality of first through holes 51A distributed to correspond to the respective electrode units 10 and two second through holes 51B arranged in a long shape and located between the plurality of first through holes 51A. Each of the first through holes 51A receives the ceramic transducer piece 12 of the corresponding electrode unit 10. The surface of the support piece 50 close to one side of the body surface of the patient is flush with the surface of the ceramic transducer 12 close to one side of the body surface of the patient, the pasting piece 60 can be flatly covered on the support piece 50 and the ceramic transducer 12, and the comfort of pasting the electrode patch 100 is improved. The two second through holes 51B respectively correspond to the portions of the stem 21 of the interposer 20 where the branches 22 extend laterally, so that part of the heat of the electrode patch 100 can be transferred from the interposer 20 to the external environment through the backing 40 to achieve the purpose of heat dissipation. Both the second through holes 51B are long holes. The first through holes 51A each have a size slightly larger than that of the electrode unit 10 at the end to which the ceramic transducer piece 12 is welded. Preferably, the support 50 is foam.

The adhesive member 60 is provided with a plurality of strips. Each of the adhesive members 60 is generally in the form of a strip having a double-sided adhesive property, and one side thereof is attached to the corresponding portion of the supporting member 50 and the ceramic transducer 12, and the other side thereof is attached to the body surface of the patient. Preferably, the adhesive element 60 is a conductive hydrogel. Each adhesive member 60 covers at least one ceramic transducer plate 12 of the electrode unit 10. In this embodiment, the adhesive member 60 is provided with 5 strips each covering 2 or 3 ceramic transducer elements 12 of the electrode unit 10. 3 adhesive pieces 60 are transversely arranged in parallel and cover the ceramic transducer plates 12 of 3 electrode units 10; there are 2 adhesive members 60 arranged longitudinally in parallel and each covering 2 ceramic transducer plates 12 of the electrode unit 10. The 2 longitudinally disposed, parallel strips of adhesive 60 are disposed on opposite sides of the 3 transversely disposed, parallel strips of adhesive 60.

The electrode patch 100 may further include at least one release paper 70. The release paper 70 is positioned on a side of the adhesive member 60 facing away from the backing 40 and covers the adhesive member 60 and the corresponding portion of the backing 40 to protect the adhesive member 60 and the backing 40 from contamination. In this embodiment, the electrode patch 100 has two release papers 70. Two release papers 70 collectively cover the adhesive member 60 and the backing 40.

Fig. 9 to 11 illustrate an electrode patch 100' according to a second embodiment of the present invention. The electrode patch 100' of the present embodiment includes an electrode unit 10', an interposer 20' detachably connected to the electrode unit 10', a lead wire 30' electrically connected to the interposer 20', a backing 40' adhered to respective portions of the electrode unit 10' and the interposer 20', a support member 50' provided around the respective portions of the electrode unit 10' and adhered to the backing 40', and an adhesive member 60' covering the support member 50' and the respective portions of the electrode unit 10' and adhered to a body surface skin corresponding to a tumor site of a patient. The electrode patch 100 'is attached to the body surface of a patient corresponding to the tumor site through the backing 40', and applies an alternating electric field to the tumor site of the patient through 1 electrode unit 10 'detachably connected to the adapter plate 20' to interfere or prevent mitosis of tumor cells of the patient, thereby achieving the purpose of treating tumors.

Compared to the electrode patch 100 of the first embodiment, the electrode patch 100' of the present embodiment also includes an interposer 20', an electrode unit 10' detachably assembled on the interposer 20', a lead wire 30' welded to the interposer 20', a backing 40' adhered to respective portions of the electrode unit 10' and the interposer 20', a support member 50' provided around the respective portions of the electrode unit 10' and adhered to the backing 40', and an adhesive member 60' covering the respective portions of the support member 50' and the electrode unit 10' and adhered to the skin of the body surface corresponding to the tumor site of the patient. The electrode unit 10 'of the electrode patch 100' of the present embodiment has the same structure as the electrode unit 10 of the electrode patch 100 of the first embodiment, and also includes an insulating plate 13 'and a ceramic transducer 12' on opposite sides of the flexible board substrate 11', and a male socket 15' on opposite ends of the flexible board substrate 11 'on the same side as the ceramic transducer 12'. The electrode patch 100' of the present embodiment is different from the electrode patch 100 of the first embodiment in that: the electrode patch 100 'comprises only one electrode unit 10' detachably plugged with the interposer 20', and the shapes of the interposer 20' and the backing 40 'are different depending on the number of plugged electrode units 10'.

As shown in fig. 9A to 11B, the interposer 20' also includes a body 28' inserted into the electrode unit 10', a female socket 25' provided on the body 28', and a wire connecting portion 27' extending laterally from the body 28'. The male socket 15' of the electrode unit 10' is plugged into the female socket 25' to electrically connect the electrode unit 10' and the interposer 20 '. The connection portion 27 'is welded to the lead 30' to electrically connect the interposer 20 'and the lead 30'. The main body 28 'has only one trunk 21', and the female sockets 25 'are disposed on the trunk 21' and located at opposite ends of the trunk 21 'with the wiring portions 27', respectively. The trunk 21' has only one set of third pads 23' thereon for soldering to the female socket 25 '. The third pad 23 'includes a third pad 23B' for transmitting a temperature signal, a third pad 23A 'for transmitting a ground signal, and a plurality of third pads 23C' for transmitting an ac signal. The plurality of third pads 23C' are electrically connected to a transmission AC signal line. The number of the third pads 23 'is six in the present embodiment, wherein one third pad 23B' for transmitting a temperature signal, one third pad 23A 'for transmitting a ground signal, and four third pads 23C' for transmitting an ac signal are provided. The female seats 25' are only one. Both side surfaces of the wire connection portion 27' are provided with a plurality of fourth pads 24' to be soldered to the wires 30 '. The fourth pad 24 'includes a fourth pad 24A' transmitting a ground signal, a fourth pad 24B 'transmitting a temperature signal, a fourth pad 24C' transmitting an ac signal, a plurality of fourth pads 24D ', and a fourth pad 24E' for shielding. The fourth pads 24D ' are respectively provided on opposite sides of the wiring portion 27' of the interposer 20 '. The fourth pads 24D ' in this embodiment are seven, two of which are disposed on the same side of the interposer 20', and the other five of which are disposed on the other side of the interposer 20 '. The two fourth pads 24D ' located on the same side are respectively disposed on the end of the wire connection portion 27' in a manner of spacing the three fourth pads 24A ', 24B ', 24C ' located on the same side. The fourth pad 24D 'can be soldered to a corresponding core of the wire 30', so as to make the soldering between the wiring portion 27 'and the wire 30' more secure, and avoid the situation that the soldering portion between the wiring portion 27 'and the wire 30' is broken when the wire 30 'is pulled by a force, which causes the interposer 20' to be damaged and unable to transmit signals.

Three second conductive traces 26 'are embedded in the interposer 20'. None of the fourth pads 24D 'is electrically connected to the second conductive trace 26'. The three second conductive traces 26 'are a second ground line 26A', a second signal line 26B ', and a second AC line 26C', respectively. The second ground line 26A ' has one end connected to the third pad 23A ' and the other end connected to a fourth pad 24A ' for transmitting a ground signal. One end of the second signal line 26B ' is connected to the third pad 23B ', and the other end is connected to the fourth pad 24B ' for transmitting a temperature signal. One end of the second AC line 26C ' is connected in series to the remaining 4 third pads 23C ', and the other end is connected to one fourth pad 24C ' for transmitting an alternating current signal. The number of the fourth pads 24' in the present embodiment is greater than the number of the fourth pads 24' connected to the second conductive trace 26, and the number of the fourth pads 24' on each side of the wire connecting portion 27' is 5, wherein the fourth pads 24' on one side include the fourth pads 24A ', 24B ', 24C ' electrically connected to the second ground line 26A ', the second signal line 26B ', and the second AC line 26C ', and two fourth pads 24D ' not electrically connected to the second ground line 26A ', the second signal line 26B ', and the second AC line 26C ', respectively. The 5 fourth pads 24 'on the other side of the wire portion 27' are all fourth pads 24D ', which are not electrically connected to the second conductive trace 26'. The fourth pads 24 'electrically connected to the second conductive traces 26' are all conductive pads 24A ', 24B', 24C ', and the fourth pads 24' not electrically connected to all the second conductive traces 26 'are all dummy pads 24D'. The 3 through pads 24A ', 24B ', 24C ' and the third pads 23A ', 23B ', 23C ' are located on the same side of the interposer 20 '. The shielding fourth pad 24E 'is also electrically connected to the second ground line 26A'.

The wire 30' has 10 cores (not shown), wherein 3 cores (not shown) are soldered to the 3 conductive pads 24A ', 24B ', 24C ' of the fourth pad 24' of the wire connection portion 27' in a one-to-one correspondence, and the remaining 7 cores (not shown) are soldered to the 7 dummy pads 24D ' in a one-to-one correspondence. The conductor 30' is provided with a plug 32' at the end remote from the terminal portion 27'. The plug 32 'may also be connected to a patch cord 33'. The number of cores (not shown) of the patch cord 33 'is the same as the number of cores (not shown) of the lead 30', and corresponds to one another. And a heat-shrinkable sleeve 31 'is coated on the periphery of the welding part of the lead 30' and the wiring part 27 'of the adapter plate 20'.

The backing 40' is generally in the form of a square sheet having at least two tabs 42' on its edge to facilitate the operator's handling of the electrode patch 100' and application of the electrode patch 100' to the body surface of the patient corresponding to the tumor site. The side of the electrode unit 10' remote from the ceramic transducer plate 12' is affixed to a backing 40 '. The backing 40' also adheres the adapter plate 20' and the corresponding portion of the heat shrink 31'. The heat shrinkable sleeve 31 can also be wrapped at the periphery of the disassembled assembly of the male seat 15 'and the female seat 25'.

The supporting member 50 'is substantially a square plate, and a through hole 51' is formed in the middle thereof. The through hole 51' is similar to the first through hole 51A of the embodiment and is used for receiving the ceramic transducer plate 12' of the electrode unit 10 '. As in the first embodiment, the support 50 'is substantially flush with the surface of the ceramic transducer plate 12' of the electrode unit 10 'on the side remote from the backing 40'.

The adhesive member 60' is disposed in a substantially square sheet shape to cover the support member 50' and a side surface of the ceramic transducer plate 12' of the electrode unit 10' away from the backing 40 '. The size of the adhesive member 60 'is substantially the same as the size of the support member 50'.

The electrode patches 100 and 100 'of the tumor electric field therapeutic apparatus (not shown) are detachably connected with the adapter plates 20 and 20' through at least one electrode unit 10 and 10', so that the failed electrode units 10 and 10' on the electrode patches 100 and 100 'can be detachably replaced, or the failed adapter plates 20 and 20' on the electrode patches 100 and 100 'can be detachably replaced, the loss of the whole electrode patches 100 and 100' is reduced, the yield loss of the electrode patches 100 and 100 'is reduced, and the scrapping and waste of the whole electrode patches 100 and 100' caused by the damage of one of the electrode units 10 and 10 'and the adapter plates 20 and 20' are avoided. In addition, the electrode patch 100 of the present application can freely select a proper number of electrode units 10 to be inserted on the adapter plate 20' according to the size of the tumor part and the position of the tumor part by matching the plurality of female seats 25 arranged on the adapter plate 20 and the electrode units 10 capable of being inserted with the female seats 25, so that the coverage area of the electrode patch 100 and the strength of the applied alternating electric field can be ensured to reach the electric field strength required by tumor treatment.

Fig. 12 is a method of manufacturing the electrode patch 100, 100' of the present invention shown in fig. 1 to 11, which includes the steps of:

s11, providing an adapter plate 20, 20', wherein the adapter plate 20, 20' is provided with at least one group of third bonding pads 23, 23 'and a wiring part 27, 27';

s12, providing at least one female seat 25, 25', and respectively welding the female seat 25, 25' on the corresponding third welding pad 23, 23 'of the adapter plate 20, 20';

s13, providing a lead 30, 30', and arranging the lead 30, 30' on the wiring part 27, 27 'of the adapter plate 20, 20';

s14, providing a heat-shrinkable sleeve 31, 31', and coating the heat-shrinkable sleeve 31, 31' at the connection position of the adapter plate 20, 20 'and the lead 30, 30';

s15, providing at least one electrode unit 10, 10' detachably connected with the adapter plate 20, 20', and clamping the electrode unit 10, 10' with the female seat 25, 25' on the adapter plate 20, 20 ';

s16, providing a backing 40, 40', and adhering the surface of the corresponding part of the adapter plate 20, 20' provided with the female seat 25, 25' on the same side with the electrode unit 10, 10' on the backing 40, 40 '.

In the above step S11, the adapter plate 20, 20 'further includes the bodies 28, 28' of the foregoing first and second embodiments. At least one set of third pads 23, 23 'is distributed on the body 28, 28'. The main bodies 28, 28 'are engaged with the wire connecting portions 27, 27'.

In the above step S13, the wires 30, 30 'may also be plugged with a patch cord 33, 33' of the first and second embodiments.

The manufacturing method of the electrode patch 100, 100' of the present invention further includes the steps of:

s17, providing a support member 50, 50', and adhering the support member 50, 50' to the backing 40, 40 'in a shape surrounding the corresponding part of the electrode unit 10, 10';

s18, providing an adhesive member 60, 60', and adhering the adhesive member 60, 60' to a surface of the support member 50, 50' on a side of the corresponding portion of the electrode unit 10, 10' away from the backing 40, 40 ';

s19, providing a release paper 70, and covering the release paper 70 on the surface of the backing 40, 40 'and the adhesive member 60, 60' close to the skin of the patient.

In step S17, the supporting members 50, 50' have at least one through hole 51, 51' to receive the corresponding portion of the corresponding electrode unit 10, 10 '.

Referring to fig. 13, the method of manufacturing the electrode unit 10, 10 'of the electrode patch 100, 100' of the present invention includes the steps of:

s21, providing a flexible board substrate 11, wherein one end of the flexible board substrate 11 is provided with a plurality of conductive discs 111 arranged at intervals and two first bonding pads 112 located in a region surrounded by the conductive discs 111, and the other end of the flexible board substrate 11 is provided with a plurality of second bonding pads 113;

s22, providing a support plate 13, and respectively arranging the support plate 13 on the flexible board substrate 11 in a one-to-one correspondence manner with the plurality of conductive discs 111, wherein the support plate 13 and the conductive discs 111 are respectively positioned at two opposite sides of the flexible board substrate 11;

s23, providing a temperature sensor 14, and welding the temperature sensor 14 on the two first bonding pads 112;

s24, providing a ceramic transducer 12 having an opening 121, and welding the ceramic transducer 12 to the plurality of conductive pads 111 in a manner that the opening accommodates a corresponding temperature sensor, wherein the temperature sensor 14 is accommodated in the opening 121 of the ceramic transducer 12;

and S25, providing a male socket 15, and welding the male socket 15 on the second pads 113.

The conductive plate 111, the first pad 112 and the second pad 113 in step S21 are all disposed on the same side surface of the flexible board substrate 11. The conductive plate 111 and the second pad 113 are respectively located at two opposite ends of the flexible board substrate 11.

The present application is only a preferred embodiment of the present application, and should not be limited to the above embodiments, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. An electrode patch for electric field therapy of tumors, which comprises at least one electrode unit, an adapter plate detachably connected with at least one electrode unit and a backing adhered to at least one electrode unit and the corresponding part of the adapter plate.

2. The electrode patch as claimed in claim 1, wherein each of the electrode units comprises a flexible board substrate, a support board and a ceramic transduction piece respectively disposed at two sides of the flexible board substrate, and a male seat disposed at the same side surface of the ceramic transduction piece of the flexible board substrate.

3. The electrode patch as claimed in claim 2, wherein the ceramic transducer and the male seat are respectively located at two opposite ends of the flexible board substrate, and the ceramic transducer and the supporting board are both located at the same end of the flexible board substrate.

4. The electrode patch as claimed in claim 2, wherein the electrode unit further comprises a temperature sensor disposed on the flexible board substrate and on the same side as the ceramic transducer.

5. The electrode patch as claimed in claim 4, wherein the ceramic transducer plate has an opening therethrough, the opening of the ceramic transducer plate receiving the temperature sensor therein.

6. The electrode patch as claimed in claim 2, wherein the adapter plate is provided with at least one female seat corresponding to and electrically connected with the male seat of the electrode unit, and the female seat of the adapter plate is detachably connected with the male seat of the electrode unit.

7. The electrode patch as claimed in claim 6, wherein the interposer includes a body and a wiring portion engaged with the body, at least one female socket of the interposer is disposed on the body, and the wiring portion is located at one end of the body.

8. The electrode patch as recited in claim 7, wherein the body has a backbone, and the at least one female seat is located on the backbone.

9. The electrode patch as claimed in claim 8, wherein the trunk of the body is provided with at least one through hole, and the through hole is disposed corresponding to the corresponding female seat.

10. The electrode patch as claimed in claim 9, wherein the through-holes allow the ceramic transduction pieces of the corresponding electrode units to pass through, and the ceramic transduction pieces of the electrode units are exposed to a side of the adaptor plate away from the female housing when the electrode unit group is disposed on the adaptor plate.

11. The electrode patch as claimed in claim 8, wherein the body further comprises a plurality of branches located at both sides of the trunk, and the female base is provided on the branches.

12. The electrode patch as claimed in claim 11, wherein a space is provided between two adjacent branches on the same side of the trunk for allowing the ceramic transduction piece of the corresponding electrode unit to pass through, and the ceramic transduction piece of the electrode unit is exposed to the side of the tab away from the female seat after passing through the space.

13. The electrode patch as claimed in claim 12, further comprising a wire electrically connected to the wiring portion of the interposer, wherein one end of the wire is electrically connected to the wiring portion of the interposer, and the other end is provided with a plug.

14. The electrode patch as claimed in claim 13, wherein a ring of heat-shrinkable sleeve is further wrapped around the connection between the lead and the wire connection portion.

15. The electrode patch as claimed in claim 13, wherein the plug of the wire is also detachably inserted into a junction line.

16. The electrode patch as claimed in claim 1, wherein the backing is provided in a sheet-like shape and has at least one through-hole corresponding to the electrode unit and provided therethrough, the through-hole of the backing allowing a corresponding portion of the electrode unit to be exposed from a side surface of the backing remote from the interposer.

17. The electrode patch of claim 16, further comprising a support member disposed around the respective portion of the electrode unit and adhered to the backing, and an adhesive member covering the support member and the respective portion of the electrode unit and engaging body surface skin of the patient corresponding to the tumor site.

18. The electrode patch as claimed in claim 17, wherein the support member has at least one perforation provided therethrough.

19. The electrode patch as claimed in claim 18, wherein the perforations comprise first perforations corresponding to the respective electrode units and receiving respective portions of the respective electrode units.

20. The electrode patch as recited in claim 19, wherein the perforations further comprise a second perforation located between the first plurality of perforations and opposite the interposer.

21. The electrode patch as defined in claim 17, further comprising at least one release paper positioned on a side of the adhesive member facing away from the backing and covering the adhesive member and the backing.

22. A method of manufacturing an electrode patch according to any one of claims 1 to 21, comprising the steps of:

23. The method of manufacturing an electrode patch according to claim 22, further comprising, after the step S16, the steps of:

s17, providing a support piece, and adhering the support piece on the backing in a shape surrounding the corresponding part of the electrode unit;

s19, providing release paper, and covering the release paper on the surface of the backing and the sticking piece close to the skin side of the patient.

24. The method of manufacturing an electrode patch according to claim 22, wherein the method of manufacturing the electrode unit comprises the steps of:

25. An electric field tumor treatment apparatus comprising an electric field generator and at least one pair of electrode patches according to any one of claims 1-21 electrically connected to the electric field generator.

26. The tumor E-field therapy apparatus of claim 25, further comprising an adapter electrically connected between said electrode patch and said electric field generator.