CN115837049A - Compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea and preparation method thereof - Google Patents
Compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea and preparation method thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention provides a compound poplar flower oral liquid for preventing and treating livestock diarrhea and a preparation method thereof. Belongs to the technical field of traditional Chinese veterinary medicines; comprises the following components in parts by weight: 2-10% of poplar flower extract, 0.001-0.1% of nano-silver, 0.01-0.5% of patchouli oil, 0.1-1.0% of active polysaccharide, 0.1-2% of surfactant, 2-10% of ethanol and the balance of purified water; the preparation method provided by the invention comprises the following steps of 1, adding patchouli oil into ethanol with a formula amount, stirring and dissolving to obtain a mixed liquid A; step 2, adding a proper amount of purified water into the poplar flower extract, the nano silver and the active polysaccharide, stirring and dissolving to obtain a mixed liquid B; step 3, adding the surfactant in the formula amount into the mixed liquid B, stirring and dissolving to obtain mixed liquid C; and 4, adding purified water to the prescription amount, and uniformly stirring to obtain the compound poplar flower oral liquid. According to the invention, the patchouli oil and the nano-silver are compounded on the basis of the poplar flower oral liquid formula, and the components are mutually cooperated, so that the livestock diarrhea is treated, the organism immunity is improved, the damaged intestinal tract is repaired, and the purpose of quick response is achieved.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea and a preparation method thereof.
Background
Dysentery and diarrhea in livestock and poultry are clinically common disease symptoms, and the most common reason is microbial factors. The microorganism includes bacteria, viruses and other pathogenic microorganisms, such as Escherichia coli, salmonella, clostridium welchii, coronavirus, etc. If the dysentery and diarrhea of the livestock and poultry are not treated in time, the health of the livestock and poultry can be harmed, and serious economic loss is caused. Clinically, the method for treating dysentery and diarrhea of livestock and poultry mainly adopts chemical drugs or traditional Chinese medicines. The chemical medicine takes an important position in a long time before due to quick effect and convenient use, but the treatment effect of the chemical medicine is greatly weakened along with the more and more serious medicine resistance, and the chemical medicine is gradually replaced by the traditional Chinese medicine which is not easy to generate the medicine resistance by proposing the concept of no resistance. However, the traditional Chinese medicine is not favored by farmers because of slow effect.
The poplar flower oral liquid is a mixture prepared by processing and extracting poplar flowers, is recorded in 2020 edition of Chinese veterinary pharmacopoeia, and has the function of mainly treating livestock and poultry dysentery and enteritis. The poplar flower oral liquid also has the common problems of using traditional Chinese medicines and has slow effect. When the traditional Chinese medicine is clinically used, other medicines are often compounded for medicine combination treatment, so that inconvenience is brought to medication of farmers. And dysentery and enteritis of livestock and poultry are accompanied by intestinal injury, and the intestinal injury is repaired to promote the digestion and absorption of the organism to food, thereby being beneficial to the recovery of the organism. Dysentery and diarrhea of livestock and poultry also indicate low immunity of livestock and poultry, and the immunity of organisms is enhanced while diseases are treated, so that the effect of achieving twice the result with half the effort can be achieved, the treatment time is shortened, and the economic loss is reduced. Therefore, the invention aims to achieve the traditional Chinese medicine oral liquid with quick response by improving the formula of the poplar flower oral liquid.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to overcome the defects of the prior art, such as incapability of achieving quick treatment effect, low bioavailability and the like; provides a compound poplar flower oral liquid for preventing and treating livestock diarrhea and a preparation method thereof. According to the invention, the nano-silver and the patchouli oil are compounded on the basis of the poplar flower oral liquid formula, and the components are mutually cooperated, so that the livestock diarrhea is treated, the organism immunity is improved, the damaged intestinal tract is repaired, and the purpose of quick response is achieved.
The technical scheme is as follows:
a compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea comprises the following raw materials in percentage by weight: 2-10% of poplar flower extract, 0.005-0.1% of nano-silver, 0.01-0.5% of patchouli oil, 0.1-1.0% of active polysaccharide, 0.1-2% of surfactant, 2-10% of ethanol and the balance of purified water.
Wherein the mass ratio of the poplar flower extract to the nano-silver is 550-650.
Further, the compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea comprises the following raw materials in percentage by weight: 3-7% of poplar flower extract, 0.005-0.012% of nano-silver, 0.05-0.25% of patchouli oil, 0.3-0.8% of active polysaccharide, 2-8% of surfactant, 3-8% of ethanol and the balance of purified water.
Further, the mass ratio of the poplar flower extract to the nano silver is 600.
Further, the active polysaccharide is one or more of lentinan, simian mushroom polysaccharide, ganoderma lucidum polysaccharide and astragalus polysaccharide.
Further, the surfactant is one or more of sucrose ester, polysorbate 80, polyoxyethylene fatty acid ester and polyoxyethylene fatty alcohol ether.
The preparation method of the compound poplar flower oral liquid for preventing and treating livestock diarrhea comprises the following steps:
step 1, adding patchouli oil into ethanol according to the prescription amount, and stirring for dissolving to obtain a solution A;
step 2, weighing a proper amount of purified water, sequentially adding the active polysaccharide, the poplar flower extract and the nano silver in the formula amount, and stirring to dissolve the active polysaccharide, the poplar flower extract and the nano silver to obtain a solution B;
step 3, adding the surfactant with the formula amount into the solution B, and stirring to dissolve the surfactant to obtain a solution C;
step 4, slowly adding the solution A into the solution C, and simultaneously quickly stirring at 50r/min for 30 minutes;
and 5, adding purified water to the amount of the prescription, and uniformly stirring to obtain the product.
The compound poplar flower oral liquid for preventing and treating livestock diarrhea is applied to treating livestock diarrhea.
Has the advantages that: compared with the prior art, the invention has the advantages that:
(1) According to the invention, the poplar flower extract and the nano-silver are compounded according to a proper proportion, and the patchouli oil and the active polysaccharide for improving the immunity are added, so that the components are mutually cooperated, the diarrhea of livestock and poultry is treated, the immunity of the organism is improved, the damaged intestinal tract is repaired, the purpose of quick effect is achieved, and the traditional Chinese medicine oral liquid gets rid of the dilemma of slow effect.
(2) The nano silver contained in the invention is prepared by nanocrystallizing silver by a leading edge nanotechnology, so that the sterilization capability of the silver in a nano state is greatly improved, few nano silver can generate strong sterilization effect, broad-spectrum sterilization is realized, no drug resistance exists, the healing of wounds, the growth of cells and the repair of damaged cells can be promoted, no toxic reaction exists, and no stimulation reaction is found to skin.
(3) The patchouli oil contained in the patchouli oil mainly contains patchouli alcohol and patchouli ketone, does not contain methyl piperitol, has the effects of resisting inflammation, resisting allergy, improving immunity, resisting bacteria, relieving pain, resisting spasm, resisting oxidation, stopping vomit and the like, and has no adverse reaction report.
(4) The active polysaccharide is a novel high-efficiency immunomodulator, can remarkably improve the phagocytic capacity of macrophages, enhances the activity of lymphocytes (T, B lymphocytes), and has the effects of resisting inflammation, bacteria and virus infection, inhibiting tumors and resisting aging.
Detailed Description
The technical solution of the present invention is described in detail below, but the scope of the present invention is not limited to the embodiments.
The raw materials of the invention are all commercial products, and the poplar flower extract is purchased from Sian Rui Ying Biotech limited company, and the content is 10 percent; the nano silver is purchased from Jianiss (China) Co., ltd, and the silver content is 99.99%; patchouli oil is purchased from natural plant GmbH of Jian city, and the total content of patchouli alcohol and patchouli ketone is more than or equal to 40%; lentinan was purchased from Dudu Qiankun animal pharmaceutical products Co., ltd, and the content was 58%; the monkeymushroom polysaccharide is purchased from Hangzhou snow domain biotechnology limited company, and the content is 10 percent; ganoderma lucidum polysaccharide is purchased from Hangzhou snow area biotechnology limited company, and the content is 30%; astragalus polysaccharides were purchased from Beijing Taier science and technology, inc. at 45% content.
Example 1
A compound poplar flower oral liquid for preventing and treating livestock diarrhea comprises the following components in percentage by weight:
3 percent of poplar flower extract
0.005 percent of nano-silver
0.25 percent of patchouli oil
Lentinan 0.8%
Sucrose ester 8%
8 percent of ethanol
And (4) purifying the balance of water.
The preparation method comprises the following steps:
1) Adding patchouli oil into the ethanol according to the prescription amount, and stirring to dissolve to obtain a solution A;
2) Weighing a proper amount of purified water, sequentially adding lentinan, the poplar flower extract and the nano-silver according to the formula ratio, and stirring to dissolve the lentinan, the poplar flower extract and the nano-silver to obtain a solution B;
3) Adding sucrose ester with the formula amount into the solution B, and stirring to dissolve the sucrose ester to obtain a solution C;
4) Slowly adding the solution A into the solution C, and rapidly stirring at 50r/min for 30 minutes;
5) Adding purified water to the amount of the prescription, and uniformly stirring to obtain the product.
Example 2
A compound poplar flower oral liquid for preventing and treating livestock diarrhea comprises the following components in percentage by weight:
4 percent of poplar flower extract
0.007% of nano-silver
0.2 percent of patchouli oil
0.2 percent of monkey mushroom polysaccharide
0.4 percent of astragalus polysaccharide
6 percent of polyoxyethylene fatty acid ester
Ethanol 7%
And (4) purifying the balance of water.
The preparation method comprises the following steps:
1) Adding patchouli oil into the ethanol according to the prescription amount, and stirring to dissolve to obtain a solution A;
2) Weighing a proper amount of purified water, sequentially adding the monkshood mushroom polysaccharide, the astragalus polysaccharide, the poplar flower extract and the nano silver in the formula amount, and stirring to dissolve the materials to obtain a solution B;
3) Adding the polyoxyethylene fatty acid ester with the formula amount into the solution B, and stirring to dissolve the polyoxyethylene fatty acid ester to obtain a solution C;
4) Slowly adding the solution A into the solution C, and rapidly stirring at 50r/min for 30 minutes;
5) Adding purified water to the amount of the prescription, and uniformly stirring to obtain the product.
Example 3
A compound poplar flower oral liquid for preventing and treating livestock diarrhea comprises the following components in percentage by weight:
5 percent of poplar flower extract
0.008 percent of nano-silver
0.15 percent of patchouli oil
Lentinan 0.1%
0.4 percent of monkey mushroom polysaccharide
Polysorbate 80% to the total weight
Ethanol 6%
And (4) purifying the balance of water.
The preparation method comprises the following steps:
1) Adding patchouli oil into the ethanol according to the prescription amount, and stirring to dissolve to obtain a solution A;
2) Weighing a proper amount of purified water, sequentially adding lentinan, monkey mushroom polysaccharide, poplar flower extract and nano silver according to the formula ratio, and stirring to dissolve the lentinan, the monkey mushroom polysaccharide, the poplar flower extract and the nano silver to obtain a solution B;
3) Adding polysorbate 80 with the formula amount into the solution B, and stirring to dissolve the polysorbate 80 to obtain a solution C;
4) Slowly adding the solution A into the solution C, and rapidly stirring at 50r/min for 30 minutes;
5) Adding purified water to the amount of the prescription, and uniformly stirring to obtain the product.
Example 4
A compound poplar flower oral liquid for preventing and treating livestock diarrhea comprises the following components in percentage by weight:
6 percent of poplar flower extract
0.01 percent of nano-silver
0.1 percent of patchouli oil
0.4 percent of ganoderma lucidum polysaccharide
Polyoxyethylene fatty alcohol ether 3%
Ethanol 5%
And (4) purifying the balance of water.
The preparation method comprises the following steps:
1) Adding patchouli oil into the ethanol according to the prescription amount, and stirring to dissolve to obtain a solution A;
2) Weighing a proper amount of purified water, sequentially adding the ganoderma lucidum polysaccharide, the poplar flower extract and the nano silver in the formula amount, and stirring to dissolve the ganoderma lucidum polysaccharide, the poplar flower extract and the nano silver to obtain a solution B;
3) Adding the polyoxyethylene fatty alcohol ether into the solution B according to the formula amount, and stirring to dissolve the polyoxyethylene fatty alcohol ether to obtain a solution C;
4) Slowly adding the solution A into the solution C, and rapidly stirring at 50r/min for 30 minutes;
5) Adding purified water to the amount of the prescription, and uniformly stirring to obtain the product.
Example 5
A compound poplar flower oral liquid for preventing and treating livestock diarrhea comprises the following components in percentage by weight:
7 percent of poplar flower extract
0.012 percent of nano-silver
Patchouli oil 0.05%
0.3 percent of astragalus polysaccharide
Polysorbate 80% and 2%
3 percent of ethanol
And (4) purifying the balance of water.
The preparation method comprises the following steps:
1) Adding patchouli oil into the ethanol according to the prescription amount, and stirring to dissolve to obtain a solution A;
2) Weighing a proper amount of purified water, sequentially adding the astragalus polysaccharide, the poplar flower extract and the nano silver according to the formula amount, and stirring to dissolve the mixture to obtain a solution B;
3) Adding polysorbate 80 with the formula amount into the solution B, and stirring to dissolve the polysorbate 80 to obtain a solution C;
4) Slowly adding the solution A into the solution C, and rapidly stirring at 50r/min for 30 minutes;
5) Adding purified water to the amount of the prescription, and uniformly stirring to obtain the product.
Comparative examples 1 to 5
On the basis of the formulations of examples 1 to 3, nano-silver and patchouli oil were not added as comparative examples 1 to 3, and the preparation steps were kept consistent.
On the basis of the formulation of example 4, no nanosilver was added, as comparative example 4, the preparation steps were kept consistent.
On the basis of the formulation of example 5, no patchouli oil was added as comparative example 5, and the preparation procedure was kept consistent.
Comparative example 6
According to the regulation of 'Chinese animal pharmacopoeia' 2020 edition, the prescription amount of the poplar flower extract (content 10.
The poplar flower oral liquid comprises the following components in percentage by weight:
10 percent of poplar flower extract
And (4) purifying the balance of water.
The preparation method comprises the following steps: dissolving the poplar flower extract in a proper amount of purified water, stirring and dissolving, and fixing the volume by using the purified water.
As comparative example 6.
Test example 1 clinical efficacy test
1 test Material
1.1 test animals: selecting 220 early weaned diarrhea piglets above 25 days old in a certain pig farm in Liuhe city.
1.2 test methods: the samples were randomly divided into 11 groups of 20 heads each. Clinical treatment trials were conducted using the products of examples 1-5 and comparative examples 1-6, respectively. Feeding 10ml each time, 2 times a day. Daily 8 in the morning, 00 in the afternoon, 13 in the afternoon, and the efficacy is observed at 18. Judging the treatment condition of the piglets in the medication period.
1.3 test drugs: the formulations prepared in examples 1 to 5 and comparative examples 1 to 6 were used as test drugs.
1.4 clinical efficacy determination:
1) After recovery and treatment, the sick piglets recover normal spirit, feed intake is normal, excrement is formed, the hardness is moderate, the color and the smell are normal, and clinical symptoms completely disappear.
2) The post-sick piglet is effectively treated to improve the mental state, enhance the appetite, improve the stool character, obviously reduce the water content and relieve the clinical symptoms.
3) After ineffective treatment, the sick piglets have no improvement in spirit, appetite and fecal characters, and are aggravated or treated by other medicines, and even die.
Test results and analysis
The results of the treatment tests on diarrhea of weaned piglets are shown in tables 1-3.
TABLE 1 EXAMPLES 1-5 AND COMPARATIVE EXAMPLES 1-6 group of formulations for treatment of diarrhea in weaned piglets
As can be seen from the results in Table 1, after the medicine is applied on the first day, the groups in examples 1-5 have better therapeutic effect on diarrhea of weaned piglets, and the total effective rate is 100%. And the cure rate is improved along with the increase of the dosage of the poplar flower extract and the nano silver additive. The total effective rate of the examples 1-5 groups was significantly higher than the comparative examples 1-5 and comparative example 6 groups. The difference between the total effective rate of the example 5 group and the total effective rate of the comparative example 5 group is not obvious, but the cure rate of the example 5 group is higher than that of the comparative example 5 group, which shows that the patchouli oil has synergistic effect with other raw materials on the formula. The total effective rate of the group 4 in the example is obviously higher than that of the group 4 in the comparative example, which shows that the nano-silver plays a key role in treating diarrhea of weaned piglets. The total effective rate of the comparative example 5 without adding the patchouli oil is obviously higher than that of the comparative example 6, the total effective rate of the comparative example 4 without adding the nano-silver is higher than that of the comparative example 6, but the difference is not obvious, so that the poplar flower extract, the nano-silver and the patchouli oil have a synergistic effect on the treatment of diarrhea of weaned piglets, and the treatment effect of the composite poplar flower oral liquid is quick to take effect compared with that of the traditional poplar flower oral liquid.
TABLE 2 EXAMPLES 1-5 AND COMPARATIVE EXAMPLES 1-6 TREATMENT OF DISEASE PILLAR DISEASE diarrhea the following day
As can be seen from the results in table 2, the cure rate of the group of examples 1-5 for the diarrhea of weaned piglets increases after the drug is applied the next day, and the cure rate increases with the increase of the dosage of the poplar flower extract and the nano silver additive. Although the total effective rate of the comparative example 6 group was also improved, the difference was not significant and the cure rate was not improved. The problem that the traditional poplar flower oral liquid has long treatment time is solved.
TABLE 3 EXAMPLES 1-5 AND COMPARATIVE EXAMPLES 1-6 TREATMENT OF DISEASE PILLAR DISEASE diarrhea on day three
As can be seen from the results in table 3, after the drug is applied on the third day, the cure rate of the weaned piglet diarrhea in examples 1-5 groups is improved, and the cure rate is improved with the increase of the dosage of the poplar flower extract and the nano silver additive. The cure rate of the comparative examples 1-4 is not improved, the cure rate of the comparative example 6 is improved by 10%, but the total effective rate is not changed, which is also related to that the weaned piglets are not treated in time after diarrhea, the disease condition is delayed, the treatment time is prolonged or the weaned piglets are dead.
The results shown in tables 1-3 indicate that the poplar flower extract, the nano-silver and the patchouli oil have a synergistic effect on the treatment of diarrhea of weaned piglets, and the treatment effect of the composite poplar flower oral liquid is quick in response compared with that of the traditional poplar flower oral liquid.
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (8)
1. The compound poplar flower oral liquid for preventing and treating livestock diarrhea is characterized by comprising the following components in parts by weight: 2-10% of poplar flower extract, 0.005-0.1% of nano-silver, 0.01-0.5% of patchouli oil, 0.1-1.0% of active polysaccharide, 1-10% of surfactant, 2-10% of ethanol and the balance of purified water.
2. The compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea according to claim 1 is characterized in that: the weight ratio of the poplar flower extract to the nano silver is 550-650.
3. The compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea according to claim 1, which is characterized in that: the raw materials comprise the following components in percentage by weight: 3-7% of poplar flower extract, 0.005-0.012% of nano-silver, 0.05-0.25% of patchouli oil, 0.3-0.8% of active polysaccharide, 2-8% of surfactant, 3-8% of ethanol and the balance of purified water.
4. The compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea according to claim 1, which is characterized in that: the mass ratio of the poplar flower extract to the nano silver is 600.
5. The compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea according to claim 1, which is characterized in that: the active polysaccharide is one or more of lentinan, simian mushroom polysaccharide, ganoderan and astragalus polysaccharide.
6. The compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea according to claim 1, which is characterized in that: the nonionic surfactant is one or more of sucrose ester, polysorbate 80, polyoxyethylene fatty acid ester and polyoxyethylene fatty alcohol ether.
7. The preparation method of the compound poplar flower oral liquid for preventing and treating livestock diarrhea according to claim 1, which is characterized by comprising the following steps: the method comprises the following steps:
step 1, adding patchouli oil into ethanol according to the prescription amount, and stirring for dissolving to obtain a solution A;
step 2, weighing a proper amount of purified water, sequentially adding the active polysaccharide, the poplar flower extract and the nano silver in the formula amount, and stirring to dissolve the active polysaccharide, the poplar flower extract and the nano silver to obtain a solution B;
step 3, adding the surfactant with the formula amount into the solution B, and stirring to dissolve the surfactant to obtain a solution C;
step 4, slowly adding the solution A into the solution C, and stirring at the same time of 50r/min for 30 minutes;
and 5, supplementing purified water to the amount of the prescription, and stirring for 10min at a speed of 50r/min to obtain the product.
8. An application of the compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea according to any one of claims 1~5 in preventing and treating livestock and poultry diarrhea.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211419386.0A CN115837049A (en) | 2022-11-14 | 2022-11-14 | Compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211419386.0A CN115837049A (en) | 2022-11-14 | 2022-11-14 | Compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104161207A (en) * | 2013-07-18 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for resisting duck bacterial diseases, preparation method and application |
| CN112471351A (en) * | 2020-11-14 | 2021-03-12 | 南京雷德蒙德农业科技有限公司 | Composition for preventing livestock and poultry diarrhea and preparation method thereof |
| CN113662991A (en) * | 2021-09-24 | 2021-11-19 | 成都维特微凡动物医药技术有限公司 | Pharmaceutical composition for treating livestock and poultry diarrhea, preparation method and application thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104161207A (en) * | 2013-07-18 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for resisting duck bacterial diseases, preparation method and application |
| CN112471351A (en) * | 2020-11-14 | 2021-03-12 | 南京雷德蒙德农业科技有限公司 | Composition for preventing livestock and poultry diarrhea and preparation method thereof |
| CN113662991A (en) * | 2021-09-24 | 2021-11-19 | 成都维特微凡动物医药技术有限公司 | Pharmaceutical composition for treating livestock and poultry diarrhea, preparation method and application thereof |
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Application publication date: 20230324 |