CN115824715A - Transdermal full-sampling and partial-sampling system - Google Patents
Transdermal full-sampling and partial-sampling system Download PDFInfo
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- CN115824715A CN115824715A CN202211600100.9A CN202211600100A CN115824715A CN 115824715 A CN115824715 A CN 115824715A CN 202211600100 A CN202211600100 A CN 202211600100A CN 115824715 A CN115824715 A CN 115824715A
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Abstract
The invention provides a transdermal full-sampling and partial-sampling system, comprising: the device comprises a diffusion pool, a sampling device, a first three-way valve, a second three-way valve, a third three-way valve and a liquid replenishing cup; the sampling device is connected with a common interface of a first three-way valve, an NO interface of the first three-way valve is connected with a common interface of a second three-way valve, an NO interface of the second three-way valve is communicated with the liquid supplementing cup, an NC interface of the second three-way valve is connected with a common interface of a third three-way valve, and the NC interface of the third three-way valve is communicated with a sampling hole arranged at the lower end of the diffusion pool. The invention can select to carry out all sampling or partial sampling; can carry out automatic fluid infusion.
Description
Technical Field
The invention relates to the technical field of automation equipment, in particular to a transdermal full-sampling and partial-sampling system.
Background
In order to simulate the drug absorption condition and detect the dissolution rates of different drugs, dissolution instrument equipment is proposed in the field of medicine and is used for detecting key indexes such as the dissolution rate of the drugs; in order to simulate the penetration of ointment on the skin surface, the cornea, the nail and other parts and research the penetration rate of the ointment, a transdermal diffusion cell instrument is provided, the principle is that the ointment is clamped on one transdermal side, a detection liquid is arranged on the other transdermal side, the liquid level of the detection liquid is contacted with one transdermal side, the ointment is separated into the detection liquid through the transdermal, and the transdermal penetration rate and the like are tested by detecting the concentration of the ointment in the detection liquid;
in order to check the concentration of the ointment in the test solution, a sample is taken.
However, the existing sampling device has the following defects:
(1) The selection of a full or partial sampling cannot be made;
(2) Automatic fluid infusion cannot be performed;
therefore, a new device needs to be developed to solve the above problems.
Disclosure of Invention
In view of the problems of the prior art, the present invention provides a transdermal full-sampling and partial-sampling system.
In order to achieve the purpose, the invention adopts the following specific scheme:
the invention provides a transdermal full-sampling and partial-sampling system, comprising: the device comprises a diffusion pool, a sampling device, a first three-way valve, a second three-way valve, a third three-way valve and a liquid replenishing cup;
the sampling device is connected with a common interface of a first three-way valve, an NO interface of the first three-way valve is connected with a common interface of a second three-way valve, an NO interface of the second three-way valve is communicated with the liquid supplementing cup, an NC interface of the second three-way valve is connected with a common interface of a third three-way valve, and the NC interface of the third three-way valve is communicated with a sampling hole arranged at the lower end of the diffusion pool;
in the liquid replenishing process, when liquid is sucked, the NC interface is opened and closed for the common interface and the NO interface of the first three-way valve, the NC interface is opened and closed for the common interface and the NO interface of the second three-way valve, and the liquid is sucked from the liquid replenishing cup by the sampling device;
when liquid is discharged, the common interface and the NO interface of the first three-way valve are opened, the NC interface is closed, the common interface and the NC interface of the second three-way valve are opened, the NO interface is closed, the common interface and the NC interface of the third three-way valve are opened, the NO interface is closed, and the sampling device injects the liquid into the diffusion pool;
in the sampling process, when liquid is sucked, the common interface and the NO interface of the first three-way valve are opened, the NC interface is closed, the common interface and the NC interface of the second three-way valve are opened, the NO interface is closed, the common interface and the NC interface of the third three-way valve are opened, and the NO interface is closed, so that the sampling device sucks the liquid from the diffusion pool;
in the process of discharging liquid, the NO interface of the public interface and the NC interface of the first three-way valve is opened and closed, and the sampling device discharges the liquid from the NO interface of the first three-way valve;
through setting up the stroke of sampling device, the control absorbs how much of liquid to realize whole sample and partial sample.
Furthermore, the first three-way valve NC interface is also connected with a sample injection needle for injecting a sample into the sample collection test tube.
Further, the sampling device is a syringe structure comprising: a hollow cylinder, a piston and a connecting rod;
the piston is arranged on the connecting rod and positioned in the hollow cylinder, and the connecting rod is used for pushing the piston to move in the hollow cylinder so as to suck liquid and discharge the liquid;
the front end of the hollow cylinder is connected with a common interface of the first three-way valve.
Furthermore, the connecting rod is also connected with a push-pull motor, and the push-pull motor is used for realizing the push-pull movement of the connecting rod.
Furthermore, the connecting rod is connected with the push-pull motor through a screw rod.
Further, the diffusion cell comprises, from top to bottom: a transparent anti-evaporation cover, a gland, a sample carrier, a filter membrane and a solvent medium pool;
the filter membrane and the sample carrier are sequentially stacked at the upper end of the solvent medium pool, the pressing cover is positioned above the filter membrane and the sample carrier and used for pressing the filter membrane and the sample carrier, a circular groove is formed in the upper side of the pressing cover, and the transparent evaporation-proof cover is positioned in the groove.
Furthermore, the edge of the upper end of the solvent medium pool is also provided with a bubble discharge hole for discharging bubbles.
Furthermore, a waste liquid groove is arranged on the side edge of the sample collecting test tube;
the upper end of the waste liquid tank is provided with two waist-shaped grooves side by side for placing different waste liquids, the left side and the right side of the waste liquid tank are respectively provided with a threaded hole for installing and fixing the waste liquid tank, and the lower end of the waste liquid tank is provided with a rectangular through hole which penetrates through the front side and the rear side.
By adopting the technical scheme of the invention, the invention has the following beneficial effects:
(1) Can choose to take the whole sample or part of the sample;
(2) Can carry out automatic fluid infusion.
Drawings
Fig. 1 is a schematic diagram of the principle of the present invention.
In the figure: 1. a sampling device; 2. a first three-way valve; 3. a sampling hole; 4. injecting a sample needle; 5. a sample collection tube; 6. a push-pull motor; 7. a screw rod; 8. a second three-way valve; 9. a liquid replenishing cup; 10. a third three-way valve; 11. a transparent anti-evaporation cover; 12. a gland; 13. a sample carrier; 14. a filter membrane sheet; 15. a solvent medium pool; 16. an air bubble discharge hole; 17. a waste liquid tank.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be further noted that, for the convenience of description, only some of the structures related to the present invention are shown in the drawings, not all of the structures.
In the description of the present invention, unless expressly stated or limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, e.g., as meaning permanently connected, removably connected, or integral to one another; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
In the description of the present embodiment, the terms "upper", "lower", "front", "rear", "left", "right", and the like are used in the orientations and positional relationships shown in the drawings only for convenience of description and simplicity of operation, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used only for descriptive purposes and are not intended to have a special meaning.
As shown in FIG. 1, the present invention provides a transdermal full-sampling and partial-sampling system comprising: the device comprises a diffusion pool, a sampling device 1, a first three-way valve 2, a second three-way valve 8, a third three-way valve 10 and a liquid supplementing cup 9; the sampling device 1 is connected with a common interface of a first three-way valve 2, an NO interface of the first three-way valve 2 is connected with a common interface of a second three-way valve 8, an NO interface of the second three-way valve 8 is communicated with a fluid infusion cup 9, an NC interface of the second three-way valve 8 is connected with a common interface of a third three-way valve 10, and the NC interface of the third three-way valve 10 is communicated with a sampling hole 3 arranged at the lower end of a diffusion pool; in the liquid supplementing process, when liquid is sucked, the NC interface is opened and closed by the public interface and the NO interface of the first three-way valve 2, the NC interface is opened and closed by the public interface and the NO interface of the second three-way valve 8, and the sampling device 1 sucks liquid from the liquid supplementing cup 9; when liquid is discharged, the common interface and the NO interface of the first three-way valve 2 are opened, the NC interface is closed, the common interface and the NC interface of the second three-way valve 8 are opened, the NO interface is closed, the common interface and the NC interface of the third three-way valve 10 are opened, and the NO interface is closed, so that the sampling device 1 injects the liquid into the diffusion pool; in the sampling process, when liquid is sucked, the NC interface is opened and closed by the common interface and the NO interface of the first three-way valve 2, the NO interface is opened and closed by the common interface and the NC interface of the second three-way valve 8, the NO interface is opened and closed by the common interface and the NC interface of the third three-way valve 10, and the liquid is sucked from the diffusion pool by the sampling device 1; in the process of discharging liquid, the NO interface of the common interface and the NC interface of the first three-way valve 2 is opened and closed, and the sampling device 1 discharges the liquid from the NO interface of the first three-way valve 2; by setting the stroke of the sampling device 1, the amount of the liquid to be sucked is controlled, so that the whole sampling and the partial sampling are realized.
The 2 NC interfaces of the first three-way valve are also connected with a sample injection needle 4 for injecting samples into a sample collection test tube 5. The sampling device 1 is a syringe structure comprising: a hollow cylinder, a piston and a connecting rod; the piston is arranged on the connecting rod and is positioned in the hollow cylinder, and the connecting rod is used for pushing the piston to move in the hollow cylinder so as to realize liquid suction and liquid discharge; the front end of the hollow cylinder is connected with a common interface of the first three-way valve 2. The connecting rod is further connected with a push-pull motor 6, and the push-pull motor 6 is used for realizing the push-pull movement of the connecting rod. The connecting rod is connected with the push-pull motor 6 through a screw rod 7.
The diffusion cell comprises the following components in sequence from top to bottom: a transparent anti-evaporation cover 11, a pressing cover 12, a sample carrier 13, a filter membrane 14 and a solvent medium pool 15; the filter membrane 14 and the sample carrier 13 are sequentially stacked at the upper end of the solvent medium pool 15, the pressing cover 12 is positioned above the filter membrane 14 and the sample carrier 13 and used for pressing the filter membrane 14 and the sample carrier 13, a circular groove is formed in the upper side of the pressing cover 12, and the transparent evaporation-proof cover 11 is positioned in the groove. The upper end edge of the solvent medium pool 15 is also provided with an air bubble discharge hole 16 for discharging air bubbles. A waste liquid groove 17 is arranged on the side edge of the sample collecting test tube 5; the upper end of the waste liquid tank 17 is provided with two waist-shaped grooves side by side for placing different waste liquids, the left side and the right side of the waste liquid tank 17 are respectively provided with a threaded hole for installing and fixing the waste liquid tank 17, and the lower end of the waste liquid tank 17 is provided with a rectangular through hole which penetrates through the front side and the rear side.
The principle of the invention is as follows:
in the process of fluid infusion
(1) Sucking liquid
The common interface and NO interface of the first three-way valve 2 are opened, and the NC interface is closed, and the common interface and NO interface of the second three-way valve 8 are opened, and the NC interface is closed;
the push-pull motor 6 pulls the piston to move backwards through the screw rod 7 and the connecting rod, and the sampling device 1 sucks liquid from the liquid supplementing cup 9;
(2) Discharging liquid
The common interface and the NO interface of the first three-way valve 2 are opened, the NC interface is opened, the NO interface of the common interface and the NC interface of the second three-way valve 8 is closed, and the NO interface of the common interface and the NC interface of the third three-way valve 10 is closed;
the push-pull motor 6 drives the piston to move forwards through the screw rod 7 and the connecting rod, and the sampling device 1 injects liquid into the solvent medium pool 15 through the sampling hole 3;
(3) Air exhaust bubble
In the process of fluid infusion, the solvent medium pool 15 is inclined at a certain angle, for example, 45 degrees, wherein the air bubble discharge hole 16 arranged at the edge of the upper end of the solvent medium pool 15 is located at the highest position,
injecting a part of liquid, such as 10ml, into the solvent medium pool 15 for the first time, injecting 5ml again for the second time, filling the solvent medium pool 15 and discharging air bubbles; the vehicle medium reservoir 15 is then returned to positive.
After the alignment, the drug was placed, heated and stirred by a magnetic stirrer.
In the sampling process
(1) When sucking liquid
The common interface and the NO interface of the first three-way valve 2 are opened, the NC interface is opened, the NO interface of the common interface and the NC interface of the second three-way valve 8 is closed, the NO interface of the common interface and the NC interface of the third three-way valve 10 is opened, and the NO interface is closed, so that the sampling device 1 sucks liquid from the diffusion pool;
(2) When discharging liquid
The common interface and NC interface of the first three-way valve 2 are opened, NO interfaces are closed, and the sampling device 1 discharges liquid from the NO interface of the first three-way valve 2 to the sample injection needle 4;
(3) Liquid in the discharge line
When sampling for the first time, discharging a set amount of liquid to a waste liquid pool, filling the pipeline with the liquid, then sampling to a sample collecting test tube 5,
after the liquid in the sampling device 1 is discharged, the liquid remains in the pipeline, at this time, the NC interface and the NO interface of the first three-way valve 2 are opened, the common interface and the NC interface of the second three-way valve 8 are opened, the NO interface is closed, the common interface and the NO interface of the third three-way valve 10 are opened, the NC interface is closed, at this time, the NO interface of the third three-way valve 10 is communicated with the atmosphere, and the liquid in the pipeline can be completely discharged into the sample collection test tube 5.
Control of partial and full sampling
The stroke of the sampling device 1 is controlled by the push-pull motor 6, and the amount of liquid sucked and discharged is controlled, so that the whole sampling and the partial sampling are realized.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (8)
1. A transdermal full-sampling and partial-sampling system, comprising: the device comprises a diffusion pool, a sampling device (1), a first three-way valve (2), a second three-way valve (8), a third three-way valve (10) and a liquid supplementing cup (9);
the sampling device (1) is connected with a common interface of a first three-way valve (2), an NO interface of the first three-way valve (2) is connected with a common interface of a second three-way valve (8), an NO interface of the second three-way valve (8) is communicated with a fluid infusion cup (9), an NC interface of the second three-way valve (8) is connected with a common interface of a third three-way valve (10), and an NC interface of the third three-way valve (10) is communicated with a sampling hole (3) arranged at the lower end of the diffusion pool;
in the liquid supplementing process, when liquid is absorbed, an NC (numerical control) interface is opened and closed by a common interface and an NO (NO) interface of the first three-way valve (2), an NC interface is opened and closed by a common interface and an NO interface of the second three-way valve (8), and the liquid is absorbed from a liquid supplementing cup (9) by the sampling device (1);
when liquid is discharged, the NC interface and the NO interface of the first three-way valve (2) are opened and closed, the NO interface and the NC interface of the second three-way valve (8) are opened and closed, the NO interface and the NC interface of the third three-way valve (10) are opened and closed, and the sampling device (1) injects the liquid into the diffusion pool;
in the sampling process, when liquid is sucked, the NC interface and the NO interface of the first three-way valve (2) are opened and closed, the NO interface and the public interface of the second three-way valve (8) are opened and closed, the NO interface and the public interface of the third three-way valve (10) are opened and closed, and the sampling device (1) sucks the liquid from the diffusion pool;
in the process of discharging liquid, the common interface and the NC interface of the first three-way valve (2) are opened, the NO interface is closed, and the sampling device (1) discharges the liquid from the NO interface of the first three-way valve (2);
the stroke of the sampling device (1) is set to control the amount of the absorbed liquid, so that the whole sampling and the partial sampling are realized.
2. Transdermal full-and partial-sampling system according to claim 1, characterized in that the NC interface of the first three-way valve (2) is also connected to a sample injection needle (4) for injecting the sample into a sample collection tube (5).
3. The transdermal full-and partial-sampling system according to claim 1, characterized in that the sampling device (1) is a syringe-like structure comprising: a hollow cylinder, a piston and a connecting rod;
the piston is arranged on the connecting rod and is positioned in the hollow cylinder, and the connecting rod is used for pushing the piston to move in the hollow cylinder so as to realize liquid suction and liquid discharge;
the front end of the hollow cylinder is connected with a common interface of the first three-way valve (2).
4. The transdermal full-and partial-sampling system according to claim 3, wherein the link is further connected to a push-pull motor (6), the push-pull motor (6) being adapted to effect the push-pull movement of the link.
5. The transdermal full-and partial-sampling system according to claim 4, wherein the link is connected to the push-pull motor (6) by a lead screw (7).
6. The transdermal full and partial sampling system according to claim 1, wherein the diffusion cell comprises, in order from top to bottom: a transparent anti-evaporation cover (11), a pressing cover (12), a sample carrier (13), a filter membrane sheet (14) and a solvent medium pool (15);
the filter membrane piece (14) and the sample carrier (13) are sequentially stacked at the upper end of the solvent medium pool (15), the pressing cover (12) is positioned above the filter membrane piece (14) and the sample carrier (13) and used for pressing the filter membrane piece and the sample carrier, a circular groove is formed in the upper side of the pressing cover (12), and the transparent evaporation-preventing cover (11) is positioned in the groove.
7. The transdermal full-and partial-sampling system according to claim 6, wherein the vehicle medium reservoir (15) is further provided at its upper end edge with a bubble discharge hole (16) for discharging bubbles.
8. A transdermal full-and partial-sampling system according to claim 2, characterized in that the sample collection tube (5) is further provided with a waste fluid reservoir (17) at its side;
the upper end of the waste liquid tank (17) is provided with two waist-shaped grooves side by side for placing different waste liquids, the left side and the right side of the waste liquid tank (17) are respectively provided with a threaded hole for installing and fixing the waste liquid tank (17), and the lower end of the waste liquid tank (17) is provided with a rectangular through hole which penetrates through the front side and the rear side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211600100.9A CN115824715A (en) | 2022-12-13 | 2022-12-13 | Transdermal full-sampling and partial-sampling system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211600100.9A CN115824715A (en) | 2022-12-13 | 2022-12-13 | Transdermal full-sampling and partial-sampling system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115824715A true CN115824715A (en) | 2023-03-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211600100.9A Pending CN115824715A (en) | 2022-12-13 | 2022-12-13 | Transdermal full-sampling and partial-sampling system |
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|---|---|
| CN (1) | CN115824715A (en) |
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- 2022-12-13 CN CN202211600100.9A patent/CN115824715A/en active Pending
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