CN115812721A - Spinosad suspending agent and preparation method and application thereof - Google Patents
Spinosad suspending agent and preparation method and application thereof Download PDFInfo
- Publication number
- CN115812721A CN115812721A CN202210010159.6A CN202210010159A CN115812721A CN 115812721 A CN115812721 A CN 115812721A CN 202210010159 A CN202210010159 A CN 202210010159A CN 115812721 A CN115812721 A CN 115812721A
- Authority
- CN
- China
- Prior art keywords
- spinosad
- spinosyn
- suspension
- agent
- suspending agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JFLRKDZMHNBDQS-UCQUSYKYSA-N CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C Chemical compound CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C JFLRKDZMHNBDQS-UCQUSYKYSA-N 0.000 title claims abstract description 112
- 239000005930 Spinosad Substances 0.000 title claims abstract description 112
- 229940014213 spinosad Drugs 0.000 title claims abstract description 112
- 239000000375 suspending agent Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- QCAWEPFNJXQPAN-UHFFFAOYSA-N methoxyfenozide Chemical compound COC1=CC=CC(C(=O)NN(C(=O)C=2C=C(C)C=C(C)C=2)C(C)(C)C)=C1C QCAWEPFNJXQPAN-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000005907 Indoxacarb Substances 0.000 claims abstract description 25
- VBCVPMMZEGZULK-NRFANRHFSA-N indoxacarb Chemical compound C([C@@]1(OC2)C(=O)OC)C3=CC(Cl)=CC=C3C1=NN2C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-NRFANRHFSA-N 0.000 claims abstract description 25
- 239000005917 Methoxyfenozide Substances 0.000 claims abstract description 24
- PSOVNZZNOMJUBI-UHFFFAOYSA-N chlorantraniliprole Chemical compound CNC(=O)C1=CC(Cl)=CC(C)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl PSOVNZZNOMJUBI-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000005886 Chlorantraniliprole Substances 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 7
- 229920000570 polyether Polymers 0.000 claims description 85
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 83
- 239000000203 mixture Substances 0.000 claims description 52
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 51
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 50
- 229910019142 PO4 Inorganic materials 0.000 claims description 49
- -1 alkyl naphthalene sulfonate formaldehyde Chemical compound 0.000 claims description 49
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 49
- 239000010452 phosphate Substances 0.000 claims description 49
- 239000000725 suspension Substances 0.000 claims description 44
- 229920000728 polyester Polymers 0.000 claims description 43
- 229920005646 polycarboxylate Polymers 0.000 claims description 42
- 125000000129 anionic group Chemical group 0.000 claims description 41
- 229930185156 spinosyn Natural products 0.000 claims description 37
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 35
- 229920002554 vinyl polymer Polymers 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 27
- 238000010008 shearing Methods 0.000 claims description 27
- 239000002562 thickening agent Substances 0.000 claims description 27
- 239000002270 dispersing agent Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000000080 wetting agent Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 239000003755 preservative agent Substances 0.000 claims description 18
- 230000002335 preservative effect Effects 0.000 claims description 18
- 239000002518 antifoaming agent Substances 0.000 claims description 15
- 150000002191 fatty alcohols Chemical class 0.000 claims description 15
- 125000005375 organosiloxane group Chemical group 0.000 claims description 14
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 230000002528 anti-freeze Effects 0.000 claims description 2
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 2
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- DWHOIYXAMUMQTI-UHFFFAOYSA-L disodium;2-[(1-sulfonatonaphthalen-2-yl)methyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC2=CC=CC=C2C(S(=O)(=O)[O-])=C1CC1=CC=C(C=CC=C2)C2=C1S([O-])(=O)=O DWHOIYXAMUMQTI-UHFFFAOYSA-L 0.000 claims description 2
- VOOLKNUJNPZAHE-UHFFFAOYSA-N formaldehyde;2-methylphenol Chemical compound O=C.CC1=CC=CC=C1O VOOLKNUJNPZAHE-UHFFFAOYSA-N 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 229920001568 phenolic resin Polymers 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000575 pesticide Substances 0.000 abstract description 16
- 241000985245 Spodoptera litura Species 0.000 abstract description 14
- 240000007124 Brassica oleracea Species 0.000 abstract description 9
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 abstract description 9
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 abstract description 9
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 abstract description 9
- 230000000749 insecticidal effect Effects 0.000 abstract description 7
- 206010059866 Drug resistance Diseases 0.000 abstract description 5
- 241000238631 Hexapoda Species 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 241000255777 Lepidoptera Species 0.000 abstract description 3
- 241000255967 Helicoverpa zea Species 0.000 abstract description 2
- 241000255969 Pieris brassicae Species 0.000 abstract description 2
- 241000500437 Plutella xylostella Species 0.000 abstract description 2
- 241000256248 Spodoptera Species 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 241000555303 Mamestra brassicae Species 0.000 abstract 1
- 241000500439 Plutella Species 0.000 abstract 1
- 241000256247 Spodoptera exigua Species 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 70
- 239000000230 xanthan gum Substances 0.000 description 42
- 235000010493 xanthan gum Nutrition 0.000 description 42
- 229920001285 xanthan gum Polymers 0.000 description 42
- 229940082509 xanthan gum Drugs 0.000 description 42
- LYRFLYHAGKPMFH-UHFFFAOYSA-N octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(N)=O LYRFLYHAGKPMFH-UHFFFAOYSA-N 0.000 description 39
- 229940037312 stearamide Drugs 0.000 description 35
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 34
- 239000004205 dimethyl polysiloxane Substances 0.000 description 31
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 31
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 30
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 24
- 239000000126 substance Substances 0.000 description 23
- 239000007798 antifreeze agent Substances 0.000 description 19
- 239000002245 particle Substances 0.000 description 18
- 239000011259 mixed solution Substances 0.000 description 17
- 238000005516 engineering process Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 12
- 239000004576 sand Substances 0.000 description 11
- 238000003860 storage Methods 0.000 description 11
- 229920001983 poloxamer Polymers 0.000 description 10
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 238000005187 foaming Methods 0.000 description 8
- 229920001296 polysiloxane Polymers 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 238000007334 copolymerization reaction Methods 0.000 description 7
- 238000005338 heat storage Methods 0.000 description 7
- 238000010998 test method Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000013530 defoamer Substances 0.000 description 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
- 239000000693 micelle Substances 0.000 description 4
- 230000002085 persistent effect Effects 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- VBCVPMMZEGZULK-UHFFFAOYSA-N indoxacarb Chemical group C1OC2(C(=O)OC)CC3=CC(Cl)=CC=C3C2=NN1C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-UHFFFAOYSA-N 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000000447 pesticide residue Substances 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- QMEQBOSUJUOXMX-UHFFFAOYSA-N 2h-oxadiazine Chemical compound N1OC=CC=N1 QMEQBOSUJUOXMX-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 1
- 241000256259 Noctuidae Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241001544359 Polyspora Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000853 biopesticidal effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of A01N25/04, and particularly relates to a spinosad suspending agent, and a preparation method and application thereof. A preparation raw material of a spinosad suspending agent comprises spinosad and a component B, wherein the component B is selected from one or more of chlorantraniliprole, indoxacarb and methoxyfenozide. The spinosad suspending agent prepared by compounding the spinosad, chlorantraniliprole, indoxacarb and methoxyfenozide has a good insecticidal effect, particularly has excellent insecticidal activity to agricultural lepidoptera pests such as cotton bollworm, plutella xylostella, cabbage caterpillar, beet armyworm, prodenia litura, cabbage prodenia plutella and the like, is particularly suitable for prodenia litura and cabbage prodenia litura, is beneficial to delaying the generation of insect resistance, can prolong the service life of pesticide varieties, reduces the use dosage, reduces the pollution to the environment, and has a good application value in the aspects of treatment and comprehensive prevention of the drug resistance of prodenia litura and cabbage armyworm.
Description
Technical Field
The invention relates to the technical field of A01N25/04, and particularly relates to a spinosad suspending agent, and a preparation method and application thereof.
Background
Chinese patent with patent application number CN201010216510.4 discloses an insecticidal composition containing methoxyfenozide and a biological source insecticide, which adopts methoxyfenozide and spinosad, solves the problem of better control of winged pests in crops, but does not disclose and solve the technical problems of reducing lasting foamability, quickly defoaming, avoiding pouring residues, improving sanding stability and improving grain size stability in the storage process.
Disclosure of Invention
In order to solve the problems, the invention provides a spinosad suspension, which is prepared from the raw materials of spinosad and a component B, wherein the component B is one or more selected from chlorantraniliprole, indoxacarb and methoxyfenozide.
Preferably, the preparation raw materials of the spinosad suspending agent comprise 8-15wt% of spinosad and the component B by weight percentage.
Preferably, the weight ratio of the spinosad to the chlorantraniliprole is (1-5): (1-5).
Preferably, the weight ratio of the spinosad to the indoxacarb is (1-3): (1-9).
Preferably, the weight ratio of the spinosad to the methoxyfenozide is (1-5): (1-5).
Spinosad is a macrolide nuisance-free high-efficiency biopesticide extracted from sugarcane polyspora spinosa fermentation liquor.
The chlorantraniliprole belongs to o-formylaminobenzoyl insecticides, can control lepidoptera pests of various crops, and has better control effect on other pests.
Indoxacarb belongs to a broad-spectrum oxadiazine pesticide, has the stomach poisoning contact effect, and can effectively prevent and control various pests.
Methoxyfenozide belongs to an insect growth regulator, can interfere the normal growth and development of insects, and has effects of stomach toxicity, and specific contact poisoning and ovicidal activity.
Provides high bactericidal effect, expands bactericidal spectrum and avoids pesticide residue and drug resistance. The inventor finds that the spinosad can be used for continuously activating the acetylcholine nicotinic receptor of the target insect by utilizing the special binding site thereof, can be combined with other components such as chlorantraniliprole/indoxacarb/methoxyfenozide and the like to promote the insecticidal effect, has no cross resistance, can expand the insecticidal spectrum and improve the application range.
Preferably, the preparation raw materials of the spinosad suspending agent comprise, by weight, 6-10wt% of a dispersing agent, 1-3wt% of a wetting agent, 0.5-1.5wt% of a thickening agent and the balance of water.
Preferably, the dispersing agent is selected from one or more of fatty alcohol-polyoxyethylene ether phosphate, calcium lignosulfonate, anionic polycarboxylate, sodium methylene-bis-naphthalene sulfonate, vinyl bis-stearamide and alkyl naphthalene sulfonate formaldehyde condensate.
Preferably, the dispersing agent comprises fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide, and the weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is (3-5): (2-4): 1.
the anionic polycarboxylate is a macromolecular compound with carboxyl, sulfonic group, amino and polyoxyethylene side chain, belongs to an anionic surfactant, does not contain harmful substances such as naphthalene, formaldehyde and the like, and reduces the pollution to the environment.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
In a preferred embodiment, as examples of the fatty alcohol polyoxyethylene ether phosphate, C12-18 fatty alcohol polyoxyethylene ether phosphate, such as AEO-3P, AEO-5P, AEO-7P, and AEO-9P, wherein the number following AEO indicates the degree of polymerization of EO, can be cited. Preferably, the EO degree of polymerization of the fatty alcohol-polyoxyethylene ether phosphate is 3-5.
In a preferable technical scheme, the fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate,
the C12-14 fatty alcohol polyoxyethylene ether phosphate is purchased from chemical technology Co, ltd in North Hu east, and the model is AEO-3P.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The inventor finds that the active ingredient outer micelle collision is increased with the increase of the storage time, particularly at higher temperature, so that the high-temperature suspensibility is influenced, and the particle size is increased, and the inventor finds that when the intermediate hydrophilic and the double-end hydrophobic bis-stearamide and the comb-shaped polycarboxylate are added and the anionic and non-active groups are contained, the anionic polycarboxylate and the fatty alcohol polyoxyethylene phosphate are utilized to jointly act, the hydrophobic stearamide structures at the two ends promote the hydrophobic effect while the charge is adsorbed by the charge, and the charge is dispersed and repelled by the NH structures, and the magnesium aluminum silicate is subjected to adsorption exchange, so that the high-temperature suspensibility is improved, the system viscosity is reduced, and the pouring residue is prevented from increasing.
The inventor also finds that when the polycarboxylate with multiple adsorption sites is used for acting, the fatty alcohol polyoxyethylene phosphate with lower EO number and better lipophilicity is used for acting, so that the density and the thickness of an adsorption film of the active ingredient can be further increased, and the action of different anionic charges is further beneficial to the action of stearamide and magnesium aluminum silicate, and the pouring efficiency is promoted.
Preferably, the wetting agent is selected from one or more of polyether polyester modified organic siloxane, EO-PO block polyether, methyl phenol formaldehyde resin, sodium dodecyl sulfate, polyoxyethylene ether and dioctyl sodium sulfosuccinate.
Preferably, the wetting agent comprises a polyether polyester modified organosiloxane and an EO-PO block polyether in a weight ratio of (0.8 to 1.5): 1.
in a preferred embodiment, the viscosity of the polyether polyester modified organosiloxane at 25 ℃ is 1000 to 5000cps, such as polyether polyester co-modified polysiloxane 8244 (viscosity at 25 ℃ is 1000 to 5000 cps) from Shanghai Raman reagent, inc.
In a preferred embodiment, the number average molecular weight of the EO-PO block polyether is 3000 to 4500, and as examples of the EO-PO block polyether, number average molecular weights of 3100, 3500, and 4100 are enumerated.
The EO-PO block polyether having a number average molecular weight of 3100 was purchased from Pasteur, germany under the type Pluronic RPE 2520.
The EO-PO block polyether having a number average molecular weight of 3500 was purchased from Pasteur, germany under the type Pluronic RPE 3100.
The EO-PO block polyether having a number average molecular weight of 4100 was purchased from Pasov Germany and was designated Pluronic RPE 1720
The inventors found that, when an anionic polycarboxylate and a fatty alcohol polyoxyethylene ether phosphate are added as the dispersant, the persistent foaming property is difficult to be reduced because of the higher foaming property of the anionic dispersant, while the inventors found that, when a polyether polyester-modified organosiloxane and an EO-PO block polyether are added, the poor affinity of the siloxane and PO blocks and water is utilized to reduce particle aggregation and creaming while simultaneously enabling easy action at the foam interface, reduce the combination of foam and foam formed by the polycarboxylate and the like, promote foam reduction, and obtain a suspension having low foaming and low persistent foaming properties.
And the inventors also found that when polyether polyester modified organosiloxane is simply added, although surface tension can be reduced, it is difficult to sufficiently combine with polycarboxylate to rapidly reduce the amount of foam, and rapid defoaming is promoted by adding a block and modified organosiloxane to work together.
Preferably, the thickening agent is selected from one or more of magnesium aluminum silicate, urea, sodium alginate, xanthan gum, sodium carboxymethylcellulose and sodium alginate.
Preferably, the thickening agent comprises magnesium aluminium silicate and xanthan gum.
Preferably, the preparation raw materials of the spinosad suspending agent further comprise 0.05-0.5wt% of preservative, 0.01-0.5wt% of defoaming agent and 4-8wt% of antifreeze agent in percentage by weight.
Preferably, the preservative is selected from one or more of propionic acid and its sodium salt, 1, 2-benzisothiazolinone, isothiazolinone, sodium benzoate, methyl p-hydroxy phenyl ester.
Preferably, the defoaming agent is selected from one or more of fatty acid esters, polyethers, polydimethylsiloxane, long-chain fatty alcohol and tributyl phosphate.
Preferably, the antifreeze agent is ethylene glycol or 1, 2-propylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
and mixing, shearing, dispersing and grinding the preparation raw materials of the spinosad suspending agent to obtain the spinosad suspending agent.
Preferably, the preparation method of the spinosad suspending agent comprises the following steps:
s1, mixing a thickening agent and an anti-freezing agent for later use;
s2, adding water, a dispersing agent, a wetting agent, a preservative and a defoaming agent into a shearing device for dispersing to obtain a mixture a;
s3, putting spinosad and the component B into a shearing device to be mixed and dispersed with the mixture a, adding a mixed solution of a thickening agent and an anti-freezing agent to be dispersed, and adding the dispersed mixture into a sand mill to be sanded;
and S4, adding the mixture into a mixing kettle after sanding is finished, and adding a defoaming agent to prepare the spinosad suspending agent.
Further, the preparation method of the spinosad suspending agent comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis-stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing device for dispersing to obtain a mixture a;
s3, putting spinosad and the component B into a shearing device to be mixed and dispersed with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and ethylene glycol to be dispersed, and adding the dispersed mixture into a sand mill to be sanded;
and S4, adding the mixture into a mixing kettle after sanding is finished, and adding the rest of polydimethylsiloxane to prepare the spinosad suspending agent.
Preferably, the S4 sand is ground to control the grain diameter D90 to be less than 3.0um.
The inventor finds that the thickening agent such as magnesium aluminum silicate and xanthan gum is added in the sanding process to promote the uniform particle size of the active ingredient in the sanding process and form stable micelle adhesion, but the inventor also finds that the large structure and water absorption of magnesium aluminum silicate and xanthan gum affect the internal water absorption and form non-uniform agglomerates, thereby affecting the particle uniformity and micelle adhesion in the sanding process, and the invention can promote the internal water absorption and expansion of the thickening agent while promoting the external water absorption and expansion of the thickening agent by mixing the thickening agent and an appropriate amount of antifreeze agent and adding the thickening agent and the antifreeze agent into a suspension system, thereby being beneficial to the stabilization of the particle size and micelle structure after sanding and reducing the particle growth in the storage process, and the inventor finds that the D50 particle size is increased after being stored for 14 days when the thickening agent and the antifreeze agent are added respectively.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Advantageous effects
In the invention, the EO-PO block polyether and polyether polyester are selected to modify organic siloxane, so that the prepared spinosad suspending agent has good low-foaming and low-lasting foaming properties in the application process.
According to the invention, vinyl distearamide, fatty alcohol polyoxyethylene ether phosphate and anionic polycarboxylate are selected as dispersing agents, so that the suspension has good suspension performance in the application process along with the increase of storage time, especially at a higher temperature, and the increase of pouring residues can be avoided.
According to the invention, the aluminum magnesium silicate and the xanthan gum are selected as the thickening agents, and the glycol is added as the antifreeze agent, so that the sanding stability can be promoted, and the particle size stability in the storage process can be improved.
The spinosad suspension prepared by compounding the spinosad with chlorantraniliprole, indoxacarb and methoxyfenozide has a good sterilization effect, the sterilization spectrum is expanded, and pesticide residues and drug resistance are avoided.
The spinosad, chlorantraniliprole, indoxacarb and methoxyfenozide are compounded in different proportions, so that the obtained spinosad suspending agent has the spinosad suspending agent, the prepared spinosad suspending agent has a good insecticidal effect, particularly, the agricultural lepidoptera pests such as cotton bollworm, plutella xylostella, cabbage caterpillar, beet noctuid, prodenia litura, cabbage prodenia enge and the like have excellent insecticidal activity, particularly, the compound use of the spinosad and the cabbage prodenia litura is beneficial to delaying the generation of drug resistance of the moths, prolonging the service life of pesticide varieties, reducing the use dosage, saving the cost, reducing the pollution to the environment, and having better application value in the aspects of drug resistance and comprehensive control of the prodenia litura and the cabbage prodenia litura.
Drawings
Fig. 1-10 are contents of a method for indoor toxicity determination of cabbage prodenia litura by a spinosad suspending agent.
FIGS. 11-19 are contents of the method for indoor toxicity determination of cabbage prodenia litura by spinosad suspending agents.
FIGS. 20-27 are the contents of the method for indoor virulence determination of Spodoptera litura with spinosad suspending agents.
Detailed Description
Example 1
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of spinosad, 8wt% of dispersant, 2wt% of wetting agent, 1.15wt% of thickener, 0.1wt% of defoamer, 0.15wt% of preservative, 6wt% of antifreeze and the balance of water.
The CAS number of the spinosad is 131929-60-7.
The dispersing agent consists of fatty alcohol polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a chemical technology company Limited in Cao of North Hu east, and the model is AEO-3P.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company Limited.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is ethylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis-stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, putting spinosad in a shearing device, mixing and dispersing with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and glycol for dispersing, and adding the dispersed mixture into a sand mill for sanding to obtain a mixture b;
and S4, finishing sanding when the D90 particle size of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 2
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of component B, 8wt% of dispersant, 2wt% of wetting agent, 1.15wt% of thickener, 0.1wt% of defoamer, 0.15wt% of preservative, 6wt% of antifreeze agent and the balance of water.
The component B is chlorantraniliprole.
The CAS number of the chlorantraniliprole is 500008-45-7.
The dispersing agent consists of fatty alcohol polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a chemical technology company Limited in Cao of North Hu east, and the model is AEO-3P.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company Limited.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited company, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is ethylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, adding chlorantraniliprole into a shearing device, mixing and dispersing the chlorantraniliprole with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and ethylene glycol for dispersing, and adding the mixture into a sand mill for sanding to obtain a mixture b after dispersing;
and S4, finishing sanding when the particle size of D90 of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 3
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of component B, 8wt% of dispersant, 2wt% of wetting agent, 1.15wt% of thickener, 0.1wt% of defoamer, 0.15wt% of preservative, 6wt% of antifreeze agent and the balance of water.
The component B is indoxacarb.
The CAS number of the indoxacarb is 144171-61-9.
The dispersing agent consists of fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a chemical technology company Limited in Cao of North Hu east, and the model is AEO-3P.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company Limited.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis-stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, putting indoxacarb into a shearing device, mixing and dispersing the indoxacarb with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and ethylene glycol for dispersing, and adding the mixture into a sand mill for sanding after dispersing to obtain a mixture b;
and S4, finishing sanding when the D90 particle size of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 4
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of component B, 8wt% of dispersant, 2wt% of wetting agent, 1.15wt% of thickener, 0.1wt% of defoamer, 0.15wt% of preservative, 6wt% of antifreeze agent and the balance of water.
The component B is methoxyfenozide.
The CAS number of the methoxyfenozide is 161050-58-4.
The dispersing agent consists of fatty alcohol polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a chemical technology company Limited in Cao of North Hu east, and the model is AEO-3P.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company Limited.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is ethylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis-stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, putting methoxyfenozide into a shearing device, mixing and dispersing with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and ethylene glycol for dispersing, and adding into a sand mill for sanding after dispersing to obtain a mixture b;
and S4, finishing sanding when the particle size of D90 of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 5
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of spinosad, a component B, 8wt% of a dispersant, 2wt% of a wetting agent, 1.15wt% of a thickening agent, 0.1wt% of a defoaming agent, 0.15wt% of a preservative, 6wt% of an antifreeze agent and the balance of water.
The weight ratio of the spinosad to the component B is 5:1.
the CAS number of the spinosad is 131929-60-7.
The component B is chlorantraniliprole.
The CAS number of the chlorantraniliprole is 500008-45-7.
The dispersing agent consists of fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a product of AEO-3P of northHubei Dongcao chemical science and technology Limited.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company Limited.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is ethylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis-stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, putting spinosad and chlorantraniliprole into a shearing device, mixing and dispersing the spinosad and the chlorantraniliprole with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and glycol for dispersing, and adding the mixture into a sand mill for sanding after dispersing to obtain a mixture b;
and S4, finishing sanding when the particle size of D90 of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 6
Example 6 provides a spinosyn suspension, which differs from example 5 in that the weight ratio of spinosyn to chlorantraniliprole in example 6 is 3:1.
example 7
Example 7 provides a spinosyn suspension, differing from example 5 in that the weight ratio of spinosyn to chlorantraniliprole in example 7 is 1:1.
example 8
Example 8 provides a spinosyn suspension, which differs from example 5 in that the weight ratio of spinosyn to chlorantraniliprole in example 8 is 1:3.
example 9
Example 9 provides a spinosyn suspension, differing from example 5 in that the weight ratio of spinosyn to chlorantraniliprole in example 9 is 1:5.
example 10
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of spinosad, a component B, 8wt% of a dispersant, 2wt% of a wetting agent, 1.15wt% of a thickening agent, 0.1wt% of a defoaming agent, 0.15wt% of a preservative, 6wt% of an antifreeze agent and the balance of water.
The weight ratio of the spinosad to the component B is 3:1.
the CAS number of the spinosad is 131929-60-7.
The component B is indoxacarb.
The CAS number of the indoxacarb is 144171-61-9.
The dispersing agent consists of fatty alcohol polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a chemical technology company Limited in Cao of North Hu east, and the model is AEO-3P.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is ethylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, putting spinosad and indoxacarb into a shearing device, mixing and dispersing the spinosad and the indoxacarb with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and ethylene glycol for dispersing, and adding the mixture into a sand mill for sanding after dispersing to obtain a mixture b;
and S4, finishing sanding when the D90 particle size of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 11
Example 11 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 11 is 1:1.
example 12
Example 12 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 12 is 1:2.
example 13
Example 13 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 13 is 1:3.
example 14
Example 14 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 14 is 1:4.
example 15
Example 15 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 15 is 1:5.
example 16
Example 16 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 16 is 1:7.
example 17
Example 17 provides a spinosad suspension, which is different from example 10 in that the weight ratio of spinosad to indoxacarb in example 17 is 1:9.
example 18
The spinosad suspending agent is prepared from the following raw materials in percentage by weight: 11.12wt% of spinosad, a component B, 8wt% of a dispersant, 2wt% of a wetting agent, 1.15wt% of a thickening agent, 0.1wt% of a defoaming agent, 0.15wt% of a preservative, 6wt% of an antifreeze agent and the balance of water.
The weight ratio of the spinosad to the component B is 5:1.
the CAS number of the spinosad is 131929-60-7.
The component B is methoxyfenozide.
The CAS number of the methoxyfenozide is 161050-58-4.
The dispersing agent consists of fatty alcohol polyoxyethylene ether phosphate, anionic polycarboxylate and vinyl bis stearamide.
The weight ratio of the fatty alcohol-polyoxyethylene ether phosphate to the anionic polycarboxylate to the vinyl bis stearamide is 4.
The fatty alcohol-polyoxyethylene ether phosphate is C12-14 fatty alcohol-polyoxyethylene ether phosphate, and the purchase manufacturer is a chemical technology company Limited in Cao of North Hu east, and the model is AEO-3P.
The anionic polycarboxylate was purchased from Hensman USA under the TER-SPERSE 2700 model.
The CAS number of the vinyl bis-stearamide is 110-30-5.
The wetting agent consists of polyether polyester modified organic siloxane and EO-PO block polyether, and the weight ratio of the polyether polyester modified organic siloxane to the EO-PO block polyether is 1:1.
the polyether polyester modified organic siloxane is polyether polyester copolymerization modified polysiloxane 8244 of Shanghai Raman reagent company Limited.
The EO-PO block polyether was purchased from Pasteur, germany and was designated as Pluronic RPE 3100.
The thickening agent comprises magnesium aluminum silicate and xanthan gum, wherein the weight ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.15.
The purchasing manufacturer of the magnesium aluminum silicate is Jinan Yingsheng chemical technology limited company, and the content of effective components is 99 percent.
The xanthan gum purchasing manufacturer is Shenzhen Lefu biotechnology limited company, and the brand is MuyuvON.
The defoaming agent is polydimethylsiloxane.
The polydimethylsiloxane is purchased from Hubei New Sihai chemical industry Co., ltd, and the specification is 20/200.
The preservative is 1, 2-benzisothiazolinone.
The CAS number of the 1, 2-benzisothiazolinone is 2634-33-5.
The antifreeze agent is ethylene glycol.
The invention provides a preparation method of a spinosad suspending agent in a second aspect, which comprises the following steps:
s1, mixing xanthan gum and ethylene glycol to obtain a mixed solution;
s2, adding water, fatty alcohol-polyoxyethylene ether phosphate, anionic polycarboxylate, vinyl bis-stearamide, polyether polyester modified organosiloxane, EO-PO block polyether, 1, 2-benzisothiazolinone and 1/2 of polydimethylsiloxane by weight into a shearing pot for shearing and dispersing to obtain a mixture a;
s3, putting spinosad and methoxyfenozide into a shearing device to be mixed and dispersed with the mixture a, adding a mixed solution of magnesium aluminum silicate, xanthan gum and ethylene glycol to be dispersed, and adding the dispersed mixture into a sand mill to be subjected to sand milling to obtain a mixture b;
and S4, finishing sanding when the D90 particle size of the mixture b is smaller than 3.0um, adding the mixture b into a mixing kettle, and adding the rest polydimethylsiloxane to prepare the spinosad suspending agent.
The third aspect of the invention provides an application of a spinosad suspending agent in the technical field of pesticide disinsection.
Example 19
Example 19 provides a spinosyn suspension, differing from example 18 in that the weight ratio of spinosyn to methoxyfenozide in example 19 is 3:1.
example 20
Example 20 provides a spinosyn suspension, differing from example 18 in that the weight ratio of spinosyn to methoxyfenozide in example 20 is 1:1.
example 21
Example 21 provides a spinosyn suspension, differing from example 18 in that the weight ratio of spinosyn to methoxyfenozide in example 21 is 1:2.
example 22
Example 22 provides a spinosyn suspension, which differs from example 18 in that the weight ratio of spinosyn to methoxyfenozide in example 22 is 1:3.
example 23
Example 23 provides a spinosyn suspension, differing from example 18 in that the weight ratio of spinosyn to methoxyfenozide in example 23 is 1:4.
example 24
Example 24 provides a spinosyn suspension, differing from example 18 in that the weight ratio of spinosyn to methoxyfenozide in example 24 is 1:5.
example 25
Example 25 provides a spinosyn suspension, which differs from example 14 in that no EO-PO block polyether is added to the raw materials for its preparation.
Example 26
Example 26 provides a spinosyn suspension, which differs from example 14 in that no fatty alcohol polyoxyethylene ether phosphate is added to the raw materials for preparing the spinosyn suspension.
Performance testing
1. Indoor toxicity test:
indoor toxicity of the spinosad suspending agent prepared in the embodiment 1, the embodiment 2 and the embodiments 5-9 on cabbage prodenia litura is determined, and the determination result is shown in table 1; the test methods and analysis of the results are shown in FIGS. 1-9.
TABLE 1
Indoor toxicity of the spinosad suspending agent prepared in the embodiment 1, the embodiment 3 and the embodiments 10-17 on cabbage prodenia litura is determined, and the determination result is shown in a table 2; the test methods and analysis of the results are shown in FIGS. 10-18.
TABLE 2
Indoor toxicity of the spinosad suspending agents prepared in the embodiment 1, the embodiment 4 and the embodiments 18-24 to prodenia litura is determined, and the determination results are shown in a table 3; the test methods and analysis of the results are shown in FIGS. 19-27.
TABLE 3
2. Heat storage, retroversion test of heat storage
The test method comprises the following steps: the pourability test was carried out according to the test method in GB/T31737-2015 method for measuring pourability of pesticides.
Test samples: the spinosyn suspensions prepared in example 7, example 14, example 18, example 25 and example 26 were tested before and after hot-storage, respectively, after hot-storage for 14 days according to GBT 19136-2003 method for determining the stability of pesticides to hot-storage at 54 ℃, and the test results are shown in Table 4.
3. Heat storage, long-lasting foamability test after Heat storage
The persistent foaming test was carried out according to the test method of GBT 28137-2011 method for determining persistent foaming of pesticides.
Test samples: the spinosyn suspensions prepared in example 7, example 14, example 18, example 25 and example 26 were tested before and after heat storage at 54 ℃ for 14 days according to GBT 19136-2003 method for determining the heat storage stability of pesticides after heat storage, and the test results are shown in Table 4.
TABLE 4
4. Particle size, suspension, wet sieve test
And (3) suspension rate determination: weighing 1.0g of sample (accurate to 0.0002 g), completely transferring the rest 25mL of suspension obtained by the method of '4.2' in GB/T14825-2006 into a 50mL volumetric flask, fixing the volume to the scale by using methanol, dissolving the sample by ultrasonic oscillation for 5min, cooling to room temperature, shaking up, accurately sucking the sample into the 5mL to 50mL volumetric flask by using a pipette, diluting to the scale by using methanol, shaking up, filtering, analyzing by liquid chromatography to obtain the mass of the active ingredients of spinosad and the component B, and calculating the suspension rate.
The wet sieve passing rate was measured according to the test method of GB/T16150-1995 method for measuring the fineness of agricultural chemicals and wettable powders.
The particle size was measured using a laser particle size analyzer and the results are shown in table 5.
Test samples: the spinosyn suspension prepared in example 14 was stored at 54 ℃ for 14 days before and after hot storage according to GBT 19136-2003 method for determining the thermal storage stability of pesticides after hot storage, and the test results are shown in Table 5.
TABLE 5
Claims (10)
1. The spinosad suspending agent is characterized in that the preparation raw materials of the spinosad suspending agent comprise spinosad and a component B, wherein the component B is one or more selected from chlorantraniliprole, indoxacarb and methoxyfenozide.
2. The spinosyn suspension of claim 1, wherein the weight ratio of spinosyn to chlorantraniliprole is (1-5): (1-5).
3. The spinosyn suspension of claim 1, wherein the weight ratio of spinosad to indoxacarb is (1-3): (1-9).
4. The spinosyn suspension of claim 1, wherein the weight ratio of spinosyn to methoxyfenozide is (1-5): (1-5).
5. The spinosyn suspension of any of claims 1-4, wherein the spinosyn suspension is prepared from raw materials comprising a dispersant, a wetting agent, a thickener, and water.
6. The spinosyn suspension of claim 5, wherein the wetting agent is selected from one or more of polyether polyester modified organosiloxanes, EO-PO block polyethers, methyl phenol formaldehyde resins, sodium dodecyl sulfate, polyoxyethylene ethers, dioctyl sodium sulfosuccinate.
7. The spinosyn suspension of claim 5, wherein the dispersing agent is selected from one or more of fatty alcohol polyoxyethylene ether phosphate, calcium lignosulfonate, anionic polycarboxylate, sodium methylenedinaphthalene sulfonate, vinyl bisstearamide, alkyl naphthalene sulfonate formaldehyde condensate.
8. The spinosad suspension formulation of claim 5, wherein the preparation raw materials of the spinosad suspension formulation further comprise a preservative, a defoaming agent and an antifreeze.
9. A method of preparing a spinosyn suspension of any of claims 5-8, comprising the steps of:
and mixing, shearing, dispersing and grinding the preparation raw materials of the spinosad suspending agent to obtain the spinosad suspending agent.
10. Use of a spinosyn suspension according to any of claims 1-8 for combating pests.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210010159.6A CN115812721A (en) | 2022-01-06 | 2022-01-06 | Spinosad suspending agent and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210010159.6A CN115812721A (en) | 2022-01-06 | 2022-01-06 | Spinosad suspending agent and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115812721A true CN115812721A (en) | 2023-03-21 |
Family
ID=85522337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210010159.6A Pending CN115812721A (en) | 2022-01-06 | 2022-01-06 | Spinosad suspending agent and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115812721A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773124A (en) * | 2010-02-12 | 2010-07-14 | 浙江升华拜克生物股份有限公司 | Compound pesticide |
| CN102113516A (en) * | 2010-01-05 | 2011-07-06 | 海南正业中农高科股份有限公司 | Insect killing compound containing chlorantraniliprole |
-
2022
- 2022-01-06 CN CN202210010159.6A patent/CN115812721A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102113516A (en) * | 2010-01-05 | 2011-07-06 | 海南正业中农高科股份有限公司 | Insect killing compound containing chlorantraniliprole |
| CN101773124A (en) * | 2010-02-12 | 2010-07-14 | 浙江升华拜克生物股份有限公司 | Compound pesticide |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8629085B2 (en) | Agrochemical compositions containing naphthalene sulfonate derivatives and nitrogen-containing surfactants | |
| CN108902158B (en) | Suspending agent containing pyraclostrobin composition and application thereof | |
| CN112930115B (en) | Liquid preparation containing biphenyl compounds and application thereof | |
| KR101131038B1 (en) | Herbicidal composition containing glyphosate in the form of a stable aqueous suspension | |
| CN103651381B (en) | A kind of mite-killing preparation and application thereof | |
| KR101548402B1 (en) | Pesticidal aqueous suspension composition | |
| CN105557717A (en) | Florasulam suspension agent and preparation method thereof | |
| CN108522512A (en) | A kind of anti-jump type fluazinam suspending agent and preparation method thereof | |
| CN104872136A (en) | Bactericide composition and preparation as well as application thereof | |
| CN115812721A (en) | Spinosad suspending agent and preparation method and application thereof | |
| CN114467955B (en) | Pesticide water suspending agent and application thereof | |
| CN109997861A (en) | Composition pesticide and its application | |
| CN104255737A (en) | Difenoconazole-propiconazole suspension emulsion and preparation method thereof | |
| CN106070233B (en) | A kind of difenoconazole dispersible oil-suspending agent and its preparation method and application | |
| CN105028457A (en) | Imidacloprid suspension and preparation method thereof | |
| CN110663686B (en) | Environment-friendly pesticide emulsifier | |
| CN110352211B (en) | Trisiloxane alkoxylate compositions | |
| CN103120178A (en) | Water-based new preparation formulation ZW of chlorpyrifos, and processing and application thereof | |
| CN103783045A (en) | Acaricide composite | |
| JP2018505902A (en) | Agrochemical granules composed of polyalkoxylate, dispersant, sugar, and polyvinylpyrrolidone | |
| JP2019518593A (en) | Foam control agent and composition thereof | |
| CN109452287A (en) | A kind of bactericidal composition and application thereof and preparation method | |
| CN109006819A (en) | A kind of bactericidal composition and application thereof containing zoxamide Yu biphenyl pyrrole bacterium amine | |
| CN117296836A (en) | Nanometer suspending agent containing bifenthrin and preparation method thereof | |
| CN117296840A (en) | Auxiliary agent composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |