CN109452287A - A kind of bactericidal composition and application thereof and preparation method - Google Patents
A kind of bactericidal composition and application thereof and preparation method Download PDFInfo
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- CN109452287A CN109452287A CN201811352303.4A CN201811352303A CN109452287A CN 109452287 A CN109452287 A CN 109452287A CN 201811352303 A CN201811352303 A CN 201811352303A CN 109452287 A CN109452287 A CN 109452287A
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- Prior art keywords
- inpyrfluxam
- dichlobentiazox
- bactericidal composition
- mass
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Abstract
The present invention relates to a kind of bactericidal composition and application thereof and preparation methods；More particularly to a kind of bactericidal composition containing Dichlobentiazox and Inpyrfluxam, preparation and application thereof and preparation method, wherein the mass ratio of Dichlobentiazox and Inpyrfluxam is (1~10): (10~1), and total content of the Dichlobentiazox and Inpyrfluxam in bactericidal composition/preparation is 1~99 mass %.Bactericidal composition/preparation of the present invention shows apparent synergistic effect to the prevention and treatment of rice sheath blight disease.Bactericidal composition and preparation of the present invention are suitable for preventing and treating the banded sclerotial blight or rice blast of cereal crop；Or it is suitable for prevention and treatment uncinula necator, scab of apple or cucumber anthracnose.
Description
Technical field
The invention belongs to composition pesticide technical field, more particularly to containing Dichlobentiazox and
The bactericidal composition of Inpyrfluxam, preparation and its preparation method and application.
Background technique
Inpyrfluxam is succinate dehydrogenase inhibitors, is wide spectrum pyrazole carboxamides fungicide.Inpyrfluxam
There is preventive effect to rice sheath blight disease, while having control efficiency to uncinula necator and scab of apple, be applicable to cotton, sweet tea
Dish, rice, apple, corn and peanut and other crops.CAS accession number is 1352994-67-2, structural formula are as follows:
Dichlobentiazox is benzothiazoles fungicide, is mainly used for preventing and treating rice disease.In 30g/hm2It uses
Under dosage, have good preventive effect to rice blast and banded sclerotial blight, under 1mg/L mass concentration to cucumber anthracnose preventive effect up to 90% with
On.CAS accession number is 957144-77-3, structural formula are as follows:
Rice sheath blight disease is one of the Major Diseases of current Rice Production.Banded sclerotial blight can prevent rice from earing, or heading
Not plump paddy it is more, grain declines again.Rice yield is caused to seriously affect.
In addition, due to the use lack of standardization of current pesticide, it is more and more stronger to the resistance of pesticide to cause disease, causes pesticide
Usage amount increase year by year so that the pollution of environment is increasingly severe.Therefore it reasonably uses pesticide and prepares composition
Fungicide come reduce dosage, expand fungicidal spectrum and reduce disease resistance it is extremely urgent.
Summary of the invention
To solve the above problems, the present invention provides a kind of bactericidal composition, it includes Dichlobentiazox and
Inpyrfluxam。
In one or more embodiments, the matter of Dichlobentiazox and Inpyrfluxam in bactericidal composition
Amount is than being (1~10): (10~1).
In one or more embodiments, the matter of Dichlobentiazox and Inpyrfluxam in bactericidal composition
Amount is than being (1~5): (5~1).
In one or more embodiments, the matter of Dichlobentiazox and Inpyrfluxam in bactericidal composition
Amount is than being (1~3): (3~1).
In one or more embodiments, the matter of Dichlobentiazox and Inpyrfluxam in bactericidal composition
Amount is than being 10: 1,7: 1,5: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 5,1: 7 or 1: 10.
In one or more embodiments, Dichlobentiazox and Inpyrfluxam are total in bactericidal composition
Content is 1~99 mass %.
In one or more embodiments, Dichlobentiazox and Inpyrfluxam are total in bactericidal composition
Content is 10~80 mass %.
In one or more embodiments, Dichlobentiazox and Inpyrfluxam are total in bactericidal composition
Content is 20~70 mass %.
In one or more embodiments, Dichlobentiazox and Inpyrfluxam are total in bactericidal composition
Content be 8 mass %, 10 mass %, 20 mass %, 24 mass %, 30 mass %, 36 mass %, 40 mass %, 50 mass %,
60 mass %, 66 mass %, 70 mass %, 80 mass % or 90 mass %.
On the other hand, the present invention provides the preparations prepared by bactericidal composition of the present invention.
In one or more embodiments, the dosage form of the preparation be missible oil, wettable powder, suspending agent, granule,
Water dispersible granules, microemulsion, aqueous emulsion or microcapsule formulations.
Another aspect, the present invention provides bactericidal composition of the present invention prevention and treatment cereal crop banded sclerotial blight or
Purposes in rice blast；Or the purposes in prevention and treatment uncinula necator, scab of apple or cucumber anthracnose.
Another aspect, the present invention provides preparations of the present invention in the banded sclerotial blight or rice blast for preventing and treating cereal crop
In purposes；Or the purposes in prevention and treatment uncinula necator, scab of apple or cucumber anthracnose.
Another aspect, the present invention provides the banded sclerotial blight of prevention and treatment cereal crop or rice blast or prevention and treatment grape white powder
Disease, the method for scab of apple or cucumber anthracnose, the method includes by bactericidal composition of the present invention and/or this hair
The bright preparation is applied to cereal crop or melon and fruit class and greengrocery crop.
Another aspect, the present invention provides the methods for preparing bactericidal composition of the present invention, and the method includes will
Dichlobentiazox and Inpyrfluxam is combined, wherein the quality of Dichlobentiazox and Inpyrfluxam such as sheet
Described in invention.
In one or more embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam are (1~10):
(10~1).
In one or more embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam are (1~5):
(5~1).
In one or more embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam are (1~3):
(3~1).
In one or more embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam are 10: 1,7:
1,5: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 5,1: 7 or 1: 10.
Another aspect, the present invention provides the methods for preparing preparation of the present invention, and the method includes will be of the invention
The bactericidal composition is in conjunction with one or more adjuvants, and wherein Dichlobentiazox and Inpyrfluxam are in preparation
In total content it is as described herein.
In one or more embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is
1~99 mass %.
In one or more embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is
10~80 mass %.
In one or more embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is
20~70 mass %.
In one or more embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is
8 mass %, 10 mass %, 20 mass %, 24 mass %, 30 mass %, 36 mass %, 40 mass %, 50 mass %, 60 matter
Measure %, 66 mass %, 70 mass %, 80 mass % or 90 mass %.
In one or more embodiments, by the preparation be prepared as missible oil, wettable powder, suspending agent, granule,
Water dispersible granules, microemulsion, aqueous emulsion or microcapsule formulations.
It is described in detail
The purpose of the present invention is to provide a kind of bactericidal composition or preparation, including Dichlobentiazox with
Inpyrfluxam, the bactericidal composition or preparation have apparent synergistic effect to rice sheath blight disease, can not only reduce effectively at
Divide dosage, reduces use cost, the generation of Disease Resistance can also be delayed.
The technical solution taken to achieve the object of the present invention is as follows:
In some embodiments, mass ratio of the Dichlobentiazox and Inpyrfluxam in bactericidal composition is
(1~10): (10~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~10): (7~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~10): (5~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~10): (3~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~10): (2~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~10): 1.
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than being 1: (10~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (2~1): (10~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (3~1): (10~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (5~1): (10~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (7~1): (10~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~5): (5~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~5): (7~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~5): (3~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~5): (2~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~5): 1.
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~7): (5~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~3): (5~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~2): (5~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than being 1: (5~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~7): (3~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~3): (3~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~3): (2~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~3): 1.
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than for (1~2): (3~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than being 1: (3~1).
In other embodiments, quality of the Dichlobentiazox and Inpyrfluxam in bactericidal composition
Than being 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9
Or 1: 10.
In some embodiments, total content of the Dichlobentiazox and Inpyrfluxam in bactericidal composition is
1~99 mass %.
In other embodiments, Dichlobentiazox and Inpyrfluxam always containing in bactericidal composition
Amount is 10~80 mass %.
In other embodiments, Dichlobentiazox and Inpyrfluxam always containing in bactericidal composition
Amount is 10~70 mass %.
In other embodiments, Dichlobentiazox and Inpyrfluxam always containing in bactericidal composition
Amount is 20~70 mass %.
In other embodiments, Dichlobentiazox and Inpyrfluxam always containing in bactericidal composition
Amount is 8 mass %, 10 mass %, 20 mass %, 24 mass %, 30 mass %, 36 mass %, 40 mass %, 50 mass %, 60
Quality %, 66 mass %, 70 mass %, 80 mass % or 90 mass %.
On the other hand, the present invention provides the preparations prepared by bactericidal composition of the present invention.
In one or more embodiments, the dosage form of the preparation be missible oil, wettable powder, suspending agent, granule,
Water dispersible granules, microemulsion, aqueous emulsion or microcapsule formulations.
Another aspect, the present invention provides bactericidal composition of the present invention prevention and treatment cereal crop banded sclerotial blight or
Purposes in rice blast；Or the purposes in prevention and treatment uncinula necator, scab of apple or cucumber anthracnose.
Another aspect, the present invention provides preparations of the present invention in the banded sclerotial blight or rice blast for preventing and treating cereal crop
In purposes；Or the purposes in prevention and treatment uncinula necator, scab of apple or cucumber anthracnose.
Another aspect, the present invention provides the banded sclerotial blight of prevention and treatment cereal crop or rice blast or prevention and treatment grape white powder
Disease, the method for scab of apple or cucumber anthracnose, the method includes by bactericidal composition of the present invention and/or this hair
The bright preparation is applied to cereal crop or gourd, fruit and vegetable class crop.
Another aspect, the present invention provides the methods for preparing bactericidal composition of the present invention, and the method includes will
Dichlobentiazox and Inpyrfluxam is combined, wherein the quality of Dichlobentiazox and Inpyrfluxam such as sheet
Described in invention.
In some embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam is (1~10): (10~
1)。
In other embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam is (1~5): (5
~1).
In other embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam is (1~3): (3
~1).
In other embodiments, the mass ratio of Dichlobentiazox and Inpyrfluxam is 10: 1,9: 1,8
: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9 or 1: 10.
Another aspect, the present invention provides the methods for preparing preparation of the present invention, and the method includes will be of the invention
The bactericidal composition is in conjunction with one or more adjuvants, and wherein Dichlobentiazox and Inpyrfluxam are in preparation
In total content it is as described herein.
In some embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is 1~99
Quality %.
In other embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is 10
~80 mass %.
In other embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is 10
~70 mass %.
In other embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is 20
~70 mass %.
In other embodiments, the total content of Dichlobentiazox and Inpyrfluxam in the formulation is 8
Quality %, 10 mass %, 20 mass %, 24 mass %, 30 mass %, 36 mass %, 40 mass %, 50 mass %, 60 matter
Measure %, 66 mass %, 70 mass %, 80 mass % or 90 mass %.
In some embodiments, the preparation is prepared as missible oil, wettable powder, suspending agent, granule, water dispersion
Granula, microemulsion, aqueous emulsion or microcapsule formulations.
Term "comprising", " comprising " or " containing " are open language, that is, include content specified by the present invention, but not
Exclude otherwise content.
The present invention can be processed into suitable various dosage forms according to actual agricultural use, comprising: aqueous suspension agent, oil suspend
Agent, water dispersible granules, microemulsion and aqueous emulsion etc..Typical preparation formulation is pulvis, wettable powder, microcapsule formulations, moisture
Scattered seed agent, granule, aqua, suspending agent, missible oil, microemulsion, aqueous emulsion, ultra-low volume spray agent, seed coat agent or fumicants.
In preparation, in addition to the active ingredient (s, usually also containing common adjuvant on pesticide.Adjuvant is Pesticide formulation
Or added in use, for improving the auxiliary substance of medicament physicochemical property, adjuvant usually basic inactive itself, but
It is that can influence control efficiency.Wherein adjuvant can be wetting agent, dispersing agent, emulsifier, thickener, disintegrating agent, antifreezing agent, disappear
Infusion, solvent, preservative, stabilizer etc. can be properly added according to the needs of preparation.
The wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, nekal, succinic acid two
Pungent rouge sodium sulfonate, Morwet EFW, GY-WS10 etc. are one such or two or more.
The dispersing agent is selected from alkyl naphthalene formaldehyde condensate sulfonate, naphthalene sulphonate, fatty alcohol ethylene oxide and adds
At object sulfonate, lignin and its derivative sulfonate, APES formaldehyde condensation products sulfat, fatty alcohol polyoxy
Ethylene ether sulfate, acrylate homopolymer sodium salt, Malaysia acid disodium salt, EO-PO block copolymer (such as Ethylan NS-
500LQ), polycarboxylate salt dispersant (such as2500), phosphoric acid ester dispersing agent (such as JR-P) etc. is therein
It is one or more kinds of.
The emulsifier is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, castor oil polyoxyethylene ether, alkyl phenol
Polyoxyethylene ether, APES formaldehyde condensation product, fatty alcohol polyoxyethylene ether, three phenethyl phenol polyoxyethylene polyoxies
Propylene ether, alkylnaphthalene sulfonate, polyoxyethylene carboxylate etc. are one such or two or more.
It is one such that the thickener is selected from white carbon black, kaolin, bentonite, xanthan gum, sodium carboxymethylcellulose etc.
Or it is two or more.
The disintegrating agent be selected from urea, bentonite, aluminium chloride, ammonium sulfate, succinic acid, sodium bicarbonate etc. it is one such or
It is two or more.
It is one such or two or more that the antifreezing agent is selected from glycerine, ethylene glycol, propylene glycol etc..
The defoaming agent is selected from organosilicon ketone defoaming agent, organic silicon defoaming agent, C8~10Fatty alcohols defoaming agent etc.
It is one such or two or more.
The solvent is toluene, dimethylbenzene, cyclohexanone, aromatic solvent, methanol, ethyl acetate, soybean oil, epoxidized soybean oil
Castor oil etc. is one such or two or more.
It is therein that the stabilizer is selected from triphenyl phosphite, aceticanhydride, epoxychloropropane, resorcinol, sodium citrate etc.
It is one or more kinds of.
It is one such or two or more that the preservative is selected from sodium benzoate, benzoic acid, potassium sorbate, Kathon CG etc..
The processing technology of the various dosage forms of preparation of the present invention, adopts equipment by known method, is Pesticide formulation
Common method in technique.
Pulvis (DP) is that a certain amount of inert dust is added in active material, such as clay, kaolin, talcum powder, through machine
The powdered object that tool is processed into, powder diameter is at 100 microns or less.
Wettable powder (WP) refer to by composition by a certain percentage with suitable surfactant and inert substance (kaolinite
Native powder) mixture.Wettable powder is the preparation for caning be uniformly dispersed Yu Shuizhong, wherein in addition to active constituent and inert substance
Other than (kaolin powder), also containing a certain amount of anion or nonionic surface active agent (dispersing agent, wetting benefit).
Microcapsule formulations (MC) are first to be coated on active matter to form small cryptomere preparation in adhesive, film forming agent etc., so
It is reprocessed into the dosage form of needs afterwards；It is divided into micro-capsule suspension (Capsule Suspensions, CS) and microcapsules granula
(Encapsulated Granule, CG), microcapsules dry suspending agent (Capsulated Dry Flowable, CDF) etc..
Water dispersion () granula (WDG) refer to by composition by a certain percentage with suitable surfactant and inert substance
The mixture of (kaolin) powder.Through air-flow crushing, particle size is made to reach requirement, and uses double helical form mixing machine and colter
Formula mixing machine keeps product mix uniform through repeatedly mixing.It is granulated and obtains by conventional method again, such as fluidized bed prilling, by spraying make
Grain, disk granulation.
Granule (GR) refer to by composition by a certain percentage with suitable surfactant, diluent and inert substance
The mixture of (kaolin powder).It is granulated by pelletizer, such as fluidized bed prilling method, is to keep powder under flow regime,
Spraying binder solution, is allowed to the prilling process being aggregated.This method makes the processes such as mixing, kneading, granulation, dry, classification exist
In one device, the short time is completed under air-tight state.
Aqua (AS) is to be dissolved in the water using certain raw medicines and Undec characteristic, is directly formulated with water
Liquid.
Suspending agent (SC) refer to composition is mixed with suitable surfactant, water or organic solvent by a certain percentage,
It is uniformly levigate through colloid mill, then grind 1 to 2 time through sand mill and be made to certain fineness.
Missible oil (EC), which refers to, to be dissolved composition in organic solvent by a certain percentage such as benzene,toluene,xylene, hexamethylene
Ketone, and be added and prepare in the mixture of a certain amount of anion or nonionic surface active agent (emulsifier).
Microemulsion (ME) is generally made of liquid pesticide, surfactant (emulsifier), water, stabilizer etc.；Its main feature is that
Using water as medium, be free of or less containing organic solvent.Drop size in microemulsion is generally several nanometers to tens nanometers, and being less than can
The a quarter of light-exposed wavelength.Aqueous emulsion is the liquid pesticidal raw medicine that will be mixed to prepare with organic solvent with 0.5-1.5 microns
The preparation that droplet is dispersed in water, appearance are milky milk shape liquid.
Aqueous emulsion (EW) is insoluble in the raw medicine liquid of water or raw medicine is dissolved in organic solvent acquired solution not soluble in water point
It dissipates in one of water formulations of pesticide.
Ultra-low volume spray agent refers to the medical fluid being sprayed onto being denoted as on object, and with superfine droplet, extremely low dosage sprays, and is
For a kind of dosage form of ultra-low volume spray application.
Seed coat agent (SD) is mixed effective component and auxiliary agent are ground, can be coated on kind of a sublist directly or after dilution
Face forms the protective film with some strength and permeability.
Fumicants (FU) is also known as smoke agent, is to mix effective component and inflammable substance etc., is burnt, make pesticide
Smog grain or a kind of medicament directly pesticide dispersion at smog grain are condensed into after gasification.
About the meaning of various adjuvants, various preparations, due to the difference in statement, the difference on understanding will cause.It answers
When understanding, various adjuvants disclosed in this field, preparation belong to the range that the application covers, such as " pesticidal preparations add
Work technology ", Luo Yanping, Song Weiwei, Chemical Industry Press, 2015；" pesticidal preparations ", Wang Kaiyun, Chinese agriculture publishing house,
2009；" Preparation Forms of Modern Pesticide processing technology book series ", Liu Guangwen, Chemical Industry Press, 2018；" formulations of pesticide and preparation and
Application method ", Tu Yuqin, Golden Shield publishing house, 2008；" Chinese pesticide ", Chinese pesticide industry association；That Deng described in
A bit.The preparation method of various preparations, include but be not limited to it is described herein those.
Compared with prior art, bactericidal composition/preparation beneficial effect of the invention is one of the following or multiple: not only
Fungicidal spectrum can be expanded, but also synergistic effect can be played, while the generation of drug resistance can be delayed, improved pair
The safety of crop also reduces drug cost, saves labour.
Specific embodiment
Below by embodiment, the invention will be further described, it should be understood for preparing described in the embodiment of the present invention
Method is only used for illustrating the present invention, rather than limitation of the invention, prepares under concept thereof of the invention to the present invention
The simple modifications of method belong to the scope of protection of present invention.All equivalents done on the basis of technical solution of the present invention
Each fall within protection scope of the present invention.
In the examples below, unless otherwise stated, all percentages are weight percentage.Raw medicine
Dichlobentiazox and Inpyrfluxam is self-control.
Indoor biometrics experiment
Mycelial growth rate method is used indoors, measures different agents to Rhizoctonia solani Kuhn (Rhizoctonia
Solani K ü hn) growth inhibiting effect, calculate each medicament to the EC of pathogen50Value.
Activated spawn:
Picking strain (set from Chinese agriculture Microbiological Culture Collection administrative center, ACCC 36246) by purchase from test tube
Among potato dextrose agar (PDA) culture medium, after being placed in 26 DEG C of incubator culture 2d, then the picking from the bacterium colony of culture
Strain is placed among new PDA culture medium, is placed in 26 DEG C of incubator culture 2d.
The weighing of sample is prepared:
A certain amount of single dose or a certain proportion of composition (being shown in Table 1) are weighed, after solvent dmso solution, is added
Containing 0.1% Tween-80 sterile water, be made into after mixing to 5mg/L, 2.5mg/L, 1.25mg/L, 0.625mg/L,
The solution of 0.3125mg/L, 0.15625mg/L each 5mL, it is spare.
Plate addition method:
Toxic plate is made using compound and culture medium: in superclean bench, (being cooled to 45mL PDA culture medium
45-50 DEG C) in the compound solution 5mL (sterilization method: ultraviolet sterilization) of bacterium of having gone out is added, be uniformly mixed, it is (straight to pour into plate
Diameter 90mm), it is cooling, repeat 3 plates.The PDA that the sterile water of equivalent emulsifier containing same solvent replaces compound solution is added
Culture medium is as blank control.
Picking inoculation fungus block (diameter 6mm) is put upside down in plate center, and 2d (incubation time is cultivated in 26 DEG C of constant incubators
It should be depending on growing state, when generally colony diameter grows to 70-80mm in blank control).It is measured with crossing method
Colony diameter.
Bacterium colony extends diameter (mm)=bacterium colony average diameter (mm) -6 (mm)
Biometrics probability value are tabled look-up according to relative inhibition and can be obtained.Using log concentration as abscissa, according to " biology is united
Count probit value conversion table ", inhibition percentage is converted into biological probability value as ordinate, draws virulence regression equation.It utilizes
The mass concentration that equation acquires when probability value are 5 is EC50(Millot M,Girardot M,Dutreix L,et
al..Antifungal and anti-biofilm activities of acetone lichen extracts against
Candida albicans.[J].Molecules,2017,22(4):651.)。
Using the co-toxicity coefficient calculation method of the abundant introduction of Sun Yun, the co-toxicity coefficient (CTC) of mixture is calculated, determines mixture
It is building performance.
(EC is generally selected using single dose a certain in mixture as standard agent50Junior), it is calculated:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Theoretical toxicity index (TTI)=A single dose toxicity index × A single dose proportion+B single dose in mixture virulence
Index × B single dose proportion in mixture.
Survey toxicity index (ATI)=standard single dose EC50Value/mixture EC50Value × 100
Co-toxicity coefficient=survey toxicity index/theoretical toxicity index × 100
Mixture has synergetic when CTC is greater than 120, is antagonism when CTC is less than 80, and CTC is phase between 80-120
Add effect.
Measurement knot of the Dichlobentiazox and Inpyrfluxam of 1 different ratio of table to rice sheath blight disease co-toxicity coefficient
Fruit
As shown in Table 1, the present invention includes the bactericidal composition of Dichlobentiazox and Inpyrfluxam, mass ratio
Example is in (1~10): when (10~1), co-toxicity coefficient is all larger than 120, shows apparent synergistic function to rice sheath blight disease.
Bactericidal composition comprising Dichlobentiazox and Inpyrfluxam can become the favourable agents of prevention and treatment rice sheath blight disease.
Embodiment 1:36%DichlobentiazoxInpyrfluxam suspending agent
1. crushing the preparation of slurry
Disperse phosphoric acid ester dispersing agent (trade name: JR-P, Nanjing Jie Run Science and Technology Ltd.) 2g, comb in 36.6g water
High-molecular compound dispersing agent (trade name: TERSPERSE 2500, Huntsman) 1.5g, the non-ionic hydroxyl of type structure are poly-
Epoxyethane block copolymer (Ethylan NS-500LQ, Nanjing Jie Run Science and Technology Ltd.) 1.5g, wetting agent (trade name:
GY-WS10, Beijing Guang Yuan benefit agriculture) 2g and silicone antifoaming agent (ETXP-40, Hangzhou Zuo Tu new material Co., Ltd)
0.4g disperses Dichlobentiazox raw medicine 27g, Inpyrfluxam 9g wherein, usesBead (Zhejiang
Jiang Jinkun Gao Ye Co., Ltd), wet pulverizing 2.0h is carried out with sand mill (the new micro machine factory in Shenyang), obtains and crushes slurry 80g.
2. the modulation of decentralized medium
Disperse xanthan gum (Aladdin reagent) 0.3g, white carbon black (Aladdin reagent) 0.4g, ethylene glycol in water 13.8g
(Aladdin reagent) 5g and sodium benzoate (Aladdin reagent) 0.5g obtains decentralized medium 20g.
3. the modulation of aqueous suspension shape composition pesticide
Above-mentioned crushing slurry 80g and decentralized medium 20g are mixed, aqueous suspension shape composition pesticide 100g is obtained,
The DichlobentiazoxInpyrfluxam suspending agent that effective component mass content is 36% is made.
Embodiment 2:24%DichlobentiazoxInpyrfluxam aqueous emulsion
1. oily mutually prepare
Dichlobentiazox raw medicine 6g, Inpyrfluxam 18g is added to cyclohexanone (Aladdin reagent) 8g and two
The in the mixed solvent of toluene (Aladdin reagent) 8g, then by emulsifier (agriculture breast 1601#, triphenyl vinyl phenol polyoxyethylene
Polyethenoxy ether, Xingtai City Yan Cheng chemical assistant Co., Ltd) 3g, castor oil polyoxyethylene ether (trade name: EMULPON CO-
360, Huntsman) 5g is added and is slowly stirred to being completely dissolved.
2. prepared by water phase
By ethylene glycol (Aladdin reagent) 3g, xanthan gum (Aladdin reagent) 0.1g, silicone antifoaming agent (ETXP-
40, Hangzhou Zuo Tu new material Co., Ltd) 0.4g, water adds 48.5g to stir evenly.
3. composition pesticide aqueous emulsion is deployed
Oil is mutually slowly added in water phase, and is stirred continuously, after being added completely into high speed disperser (trade name:
TG25, German IKA) (8000 revs/min) 15 minutes under high shear, it is 24% that effective component mass content, which is made,
DichlobentiazoxInpyrfluxam aqueous emulsion.
Embodiment 3:66%DichlobentiazoxInpyrfluxam water dispersible granules
By Dichlobentiazox raw medicine 22g, Inpyrfluxam44g, the high-molecular compound dispersing agent of comb-type structure
(trade name: TERSPERSE 2500, Huntsman) 2g, lignin C (Guangzhou Cong Zhongxiao Chemical Co., Ltd.) 3g, ammonium sulfate
(Aladdin reagent) 5g, aluminium-magnesium silicate (Aladdin reagent) 0.4g, white carbon black (Hangzhou Zuo Tu new material Co., Ltd) 0.3g,
WJB-20 (Shanghai Wan Jin Co., Ltd) 0.2g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) add to 100g, first precomminution
It mixes, then through air-flow crushing (the excellent nanogram Machinery Co., Ltd. in Kunshan) to required partial size (0-5 microns), again using rotating pelletizer
It is granulated, the DichlobentiazoxInpyrfluxam water dispersible granules that effective component mass content is 66% is made.
Embodiment 4:60%DichlobentiazoxInpyrfluxam wettable powder
By Dichlobentiazox raw medicine 30g, Inpyrfluxam 30g, naphthalene sulphonate (trade name: Morwet
D-425, Akzo Nobel) 5g, lignin C (Hangzhou Zuo Tu new material Co., Ltd) 3g, ammonium sulfate (Aladdin reagent) 5g,
Xanthan gum (Aladdin reagent) 0.5g, organic silicone (trade name: DOW CORNING ANTIFOAM C EMULSION, DOW
CORNING) 0.2g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) add to 100g, and first precomminution mixes, then through air-flow crushing
(the excellent nanogram Machinery Co., Ltd. in Kunshan) to required partial size (0-5 microns), it is 60% that effective component mass content, which is made,
DichlobentiazoxInpyrfluxam wettable powder.
Embodiment 5:8%DichlobentiazoxInpyrfluxam microemulsion
1. oily mutually prepare
Dichlobentiazox raw medicine 2g, Inpyrfluxam 6g is added to cyclohexanone (Aladdin reagent) 8g and AG-
The in the mixed solvent of 1705 (environment-friendly type solvent, Huntsman) 5g, then by (the alkyl phenol block polyether of emulsifier TERMUL 200
Copoly type emulsifier, Huntsman) 10g, agriculture breast 1601# (triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether, Xingtai City swallow
Sincere chemical assistant Co., Ltd) 14g is added and is slowly stirred to being completely dissolved.
2. prepared by water phase
By n-butanol (Aladdin reagent) 4g, silicone antifoaming agent (ETXP-40, the limited public affairs of the left native new material in Hangzhou
Department) 0.2g, deionized water 50.8g stir evenly.
3. composition aqueous emulsion is deployed
Oil is mutually slowly added in water phase, and is stirred continuously until transparence, it is 8% that effective component mass content, which is made,
DichlobentiazoxInpyrfluxam microemulsion.
Reference examples 1:40%Dichlobentiazox suspending agent
1. crushing the preparation of slurry
Disperse non-induced by alkyl hydroxybenzene dispersant with high efficiency (trade name: TERSPERSE 4894, Huntsman) in 32.7g water
High-molecular compound dispersing agent (trade name: TERSPERSE 2500, Huntsman) 2g, wetting agent (commodity of 2g, comb-type structure
Name: GY-WS10, Beijing Guang Yuan benefit agriculture) 3g and silicone antifoaming agent (ETXP-40, Hangzhou Zuo Tu new material Co., Ltd)
0.3g disperses Dichlobentiazox raw medicine 40g wherein, usesBead, with sand mill, (Shenyang is newly micro-
Electrical machinery plant) wet pulverizing 1.5h is carried out, it obtains and crushes slurry 80g.
2. the modulation of decentralized medium
Disperse xanthan gum (Aladdin reagent) 0.2g, aluminium-magnesium silicate (Aladdin reagent) 0.5g, ethylene glycol in 15.2g water
(Aladdin reagent) 4g and sodium benzoate (Aladdin reagent) 0.1g obtains decentralized medium 20g.
3. the modulation of aqueous suspension shape composition pesticide
Above-mentioned crushing slurry 80g and decentralized medium 20g are mixed, aqueous suspension shape composition pesticide 100g is obtained,
The Dichlobentiazox suspending agent that effective component mass content is 40% is made.
Reference examples 2:40%Inpyrfluxam wettable powder
By Inpyrfluxam 40g, naphthalene sulphonate (trade name: Morwet D-425, Akzo Nobel) 5g,
Lignin C (Hangzhou Zuo Tu new material Co., Ltd) 3g, ammonium sulfate (Aladdin reagent) 5g, xanthan gum (Aladdin reagent)
0.5g, organic silicone (trade name: DOW CORNING ANTIFOAM C EMULSION, DOW CORNING) 0.2g, kaolin
(Hangzhou Zuo Tu new material Co., Ltd) adds to 100g, and first precomminution mixes, then (the excellent nanogram machinery in Kunshan is limited through air-flow crushing
Company) to required partial size (0-5 microns), the Inpyrfluxam wettable powder that effective component mass content is 40% is made.
Field control effectiveness test
Test process: according to the reagent agent experimental design in table 2, three are set separately to the test medicine of embodiment 1-3
A effective ingredient consumption.Comparison medicament is in 40%Dichlobentiazox suspending agent and reference examples 2 in reference examples 1 respectively
40%Inpyrfluxam wettable powder and blank clear water.
The design of 2. reagent agent field control effectiveness test of table
Cell setting: each plot area is 66.7m2；
Application method: medicament is administered in rice sheath blight disease early stage, foliar spray processing, and spouting liquid is with drop of not dripping
It is main.
Spraying times: 3 times, strong wind day or it is expected that rainfall in 1 hour, is not administered.State of an illness radix is investigated before application for the first time, with
It was administered afterwards every 7 days 1 time, 7 days investigation preventive effects after the 3rd application.
Control time and number: progress radix investigation in 1 day after application, 7 days, progress disease index investigation in 14 days after medicine.
Investigation method: according to rice leaf sheath and blade hazard symptoms grading, as unit of strain, every cell diagonal line five
Point sampling, every investigation are connected 5 clumps, and totally 25 clumps, record total strain number, diseased plant number and sick series.
Inspection drug effect method after investigating and prevent and treat before application are as follows: 5 points of grab sample in test process area record total leaf
Number, the sick number of sheets, sick series.Grade scale method is as follows:
0 grade: complete stool is disease-free；
1 grade: quaterfoil and its following leaf sheath, blade morbidity (with sword-like leave for first leaf)；
3 grades: third blade and its following leaf sheath, blade morbidity；
5 grades: second blades and its following leaf sheath, blade morbidity；
7 grades: sword-like leave and its following leaf sheath, blade morbidity；
9 grades: complete stool morbidity, it is withered ahead of time.
Drug effect calculates:
Test result is detailed in the following table 3.
3. reagent agent field control effectiveness test result of table
As shown in Table 3, the bactericidal composition of Dichlobentiazox and Inpyrfluxam of the present invention are to rice sheath blight disease
There is good control efficiency, and has a very long lasting period.Bactericidal composition of the present invention is compared with single dose, quick-acting and holding effect
Property be superior to control single dose, the two compounding after can show synergistic function, it is possible to reduce times for spraying.In addition, with
It does not find that composition pesticide of the invention has phytotoxicity generation to rice within the scope of medicine, shows bactericidal composition of the invention to crop
Safety is good, can promote and apply.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. bactericidal composition, it includes Dichlobentiazox and Inpyrfluxam.
2. bactericidal composition according to claim 1, the wherein mass ratio of Dichlobentiazox and Inpyrfluxam
For (1~10): (10~1)；Preferably (1~5): (5~1)；More preferably (1~3): (3~1).
3. bactericidal composition according to claim 1, wherein Dichlobentiazox and Inpyrfluxam is killed described
Total content in bacteria composition is 1~99 mass %；Preferably 10~80 mass %；More preferably 20~70 mass %.
4. the preparation of the preparation of the bactericidal composition as described in any one of claim 1-3.
5. preparation according to claim 4, wherein the dosage form of the preparation is missible oil, wettable powder, suspending agent, particle
Agent, water dispersible granules, microemulsion, aqueous emulsion or microcapsule formulations.
6. bactericidal composition described in any one of claim 1-3 is in the banded sclerotial blight of prevention and treatment cereal crop or rice blast
Purposes；
Or the purposes in prevention and treatment uncinula necator, scab of apple or cucumber anthracnose.
7. purposes of the preparation described in claim 4 or 5 in the banded sclerotial blight of prevention and treatment cereal crop or rice blast；Or anti-
Control the purposes in uncinula necator, scab of apple or cucumber anthracnose.
8. the banded sclerotial blight or rice blast or prevention and treatment uncinula necator, scab of apple or cucumber anthracnose of prevention and treatment cereal crop
Method comprising by bactericidal composition and/or system described in claim 4 or 5 described in any one of claim 1-3
Agent is applied to cereal crop or melon and fruit class and greengrocery crop.
9. the method for preparing bactericidal composition described in any one of claim 1-3, the method includes will
Dichlobentiazox and Inpyrfluxam is combined, and the mass ratio of preferably Dichlobentiazox and Inpyrfluxam are
(1~10): (10~1)；Preferably (1~5): (5~1)；More preferably (1~3): (3~1).
10. the method for preparing preparation described in claim 4 or 5, the method includes by any one of claim 1-3 institute
The bactericidal composition stated is in conjunction with one or more adjuvants, and wherein Dichlobentiazox and Inpyrfluxam is in the system
Total content in agent is 1~99 mass %；Preferably 10~80 mass %；More preferably 20~70 mass %；It is preferably described
The dosage form of preparation is missible oil, wettable powder, suspending agent, granule, water dispersible granules, microemulsion, aqueous emulsion or microcapsule formulations.
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| CN115943963A (en) * | 2022-12-22 | 2023-04-11 | 四川利尔作物科学有限公司 | Sterilization composition containing methionin and dichlobeniazox and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102858163A (en) * | 2010-04-28 | 2013-01-02 | 住友化学株式会社 | Plant disease control composition and its use |
| CN102958367A (en) * | 2010-06-24 | 2013-03-06 | 住友化学株式会社 | Plant disease control composition and method of controlling plant disease |
| CN104640448A (en) * | 2012-07-20 | 2015-05-20 | 住友化学株式会社 | Composition for controlling plant disease and application therefor |
| CN106937636A (en) * | 2017-04-22 | 2017-07-11 | 北京科发伟业农药技术中心 | The bactericidal composition of fluorine-containing azoles ring bacterium amine |
| CN106942236A (en) * | 2017-05-06 | 2017-07-14 | 北京科发伟业农药技术中心 | The composition of fluorine-containing azoles bacterium aniline and Dichlobentiazox |
| CN107410322A (en) * | 2017-04-17 | 2017-12-01 | 北京科发伟业农药技术中心 | The bactericidal composition of the fluorine bacterium azoles of alkene containing benzo |
-
2018
- 2018-11-14 CN CN201811352303.4A patent/CN109452287A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102858163A (en) * | 2010-04-28 | 2013-01-02 | 住友化学株式会社 | Plant disease control composition and its use |
| CN102958367A (en) * | 2010-06-24 | 2013-03-06 | 住友化学株式会社 | Plant disease control composition and method of controlling plant disease |
| CN104640448A (en) * | 2012-07-20 | 2015-05-20 | 住友化学株式会社 | Composition for controlling plant disease and application therefor |
| CN107410322A (en) * | 2017-04-17 | 2017-12-01 | 北京科发伟业农药技术中心 | The bactericidal composition of the fluorine bacterium azoles of alkene containing benzo |
| CN106937636A (en) * | 2017-04-22 | 2017-07-11 | 北京科发伟业农药技术中心 | The bactericidal composition of fluorine-containing azoles ring bacterium amine |
| CN106942236A (en) * | 2017-05-06 | 2017-07-14 | 北京科发伟业农药技术中心 | The composition of fluorine-containing azoles bacterium aniline and Dichlobentiazox |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115943963A (en) * | 2022-12-22 | 2023-04-11 | 四川利尔作物科学有限公司 | Sterilization composition containing methionin and dichlobeniazox and application thereof |
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