CN110463709A - Composition, preparation and its application - Google Patents
Composition, preparation and its application Download PDFInfo
- Publication number
- CN110463709A CN110463709A CN201910773377.3A CN201910773377A CN110463709A CN 110463709 A CN110463709 A CN 110463709A CN 201910773377 A CN201910773377 A CN 201910773377A CN 110463709 A CN110463709 A CN 110463709A
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- Prior art keywords
- florylpicoxamid
- dimethachlon
- preparation
- composition
- mass ratio
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of composition, preparation and its application；Specifically, the present invention relates to a kind of bactericidal composition containing Florylpicoxamid and dimethachlon and preparation and its applications, it is 1~90wt.% that wherein the mass ratio of effective component Florylpicoxamid and dimethachlon, which is the total content of 1~10: 10~1, Florylpicoxamid and dimethachlon in bactericidal composition or preparation,.The present composition and preparation show apparent synergistic effect to the prevention and treatment of wheat powdery mildew.The prevention and treatment of bactericidal composition and preparation of the present invention suitable for the powdery mildew of cereal crop, banded sclerotial blight, rust, sclerotiniose, rice blast and gourd, fruit and vegetable anthracnose.
Description
Technical field
The present invention relates to technical field of pesticide, and in particular to a kind of sterilization containing Florylpicoxamid and dimethachlon
Composition, preparation and its application.
Background technique
Florylpicoxamid (trade name: Adavelt) is the picolinamide class fungicide of Tao benefit agriculture exploitation, is made
It is to be killed by inhibiting the mitochondrial respiratory on fungi complex III Qi ubiquinone (i.e. ubiquinone) binding site to act on to play with mechanism
Bacterium activity.For cereal, grape, fruit tree, nutwood, vegetables etc., powdery mildew, anthracnose, shot hole and by septoria musiva are prevented and treated
Disease caused by the pathogens such as bacterium, botrytis (Botrytis spp.), alternaric bacteria, chain sclerotinia sclerotiorum.
Florylpicoxamid chemical name is bis- (4- the fluorophenyl) -1- Methylethyl-N- of (1S) -2,2- [[3- (acetoxyl group) -4-
Methoxyl group -2- pyridyl group] carbonyl]-l-Alanine, structural formula are as follows:
Dimethachlon is heterocyclic compound, belongs to imines fungicide.Dimethachlon is to wheat powdery mildew, sclerotinia sclerotiorum, cigarette
Careless rust etc. has good control efficiency.Dimethachlon structural formula are as follows:
Due to the use lack of standardization of current pesticide, it is more and more stronger to the resistance of pesticide to cause disease, causes making for pesticide
Dosage increases year by year, so that the pollution of environment is increasingly severe.Therefore the drug or drug of a kind of low dosage high-drug-effect are found
Composition is very necessary.
Summary of the invention
To solve the above problems, the one side present invention provides a kind of composition, it includes Florylpicoxamid and sclerotium
Only；It not only solves the excessively high problem of prior art dosage, and wider, quick-acting and long-acting and other effects with fungicidal spectrum.
Composition of the present invention is mainly used for preventing and treating powdery mildew, banded sclerotial blight, rust, the sclerotiniose, rice of cereal crop
Seasonal febrile diseases and gourd, fruit and vegetable anthracnose etc..Wherein the mass ratio of Florylpicoxamid and dimethachlon can be in very large range
Change, it is applied widely, effect is good, it is at low cost, residual it is low, it is safe for human, animal and environment.It is provided by the invention
There is not been reported for the composition of Florylpicoxamid and dimethachlon.
In some of embodiments, Florylpicoxamid and the mass ratio of dimethachlon in the composition be 1~
10: 10~1.
In other embodiment, Florylpicoxamid and the mass ratio of dimethachlon in the composition be 1~
10: 5~1.
Also in some embodiments, Florylpicoxamid and the mass ratio of dimethachlon in the composition be 1~
10∶1。
Also in some embodiments, Florylpicoxamid and the mass ratio of dimethachlon in the composition be 3~
10∶1。
Also in some embodiments, Florylpicoxamid and the mass ratio of dimethachlon in the composition are 1:
10~1.
In some of embodiments, Florylpicoxamid and the total content of dimethachlon in the composition be 1~
90wt.%.
In other embodiment, Florylpicoxamid and the total content of dimethachlon in the composition are 10
~50wt.%.
Also in some embodiments, Florylpicoxamid and the total content of dimethachlon in the composition are 15
~45wt.%.
Also in some embodiments, Florylpicoxamid is with the total content of dimethachlon in the composition
18wt.%, 30wt.%, 35wt.% or 44wt.%.
Further, composition of the present invention is bactericidal composition, includes effective component, institute in the bactericidal composition
Stating effective component includes Florylpicoxamid and dimethachlon.
Further, composition of the present invention is bactericidal composition, includes effective component in the bactericidal composition,
The effective component is Florylpicoxamid and dimethachlon.
In some of embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 1~15 in bactericidal composition
: 15~1.
In some of embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 1~10 in bactericidal composition
: 10~1.
In other embodiment, the mass ratio of Florylpicoxamid and dimethachlon is 1~10 in bactericidal composition
: 5~1.
Also in some embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 1~10 in bactericidal composition
∶1。
Also in some embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 1: 10 in bactericidal composition
~1.
Also in some embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 3~10 in bactericidal composition
∶1。
Specifically, in bactericidal composition the mass ratio of Florylpicoxamid and dimethachlon be 1: 1,1: 3,1: 5,1: 10,
1: 13,1: 15,3: 1,5: 1,10: 1,13: 1 or 15: 1.
Preferably, the mass ratio of Florylpicoxamid and dimethachlon is 1: 1,3: 1,5: 1 or 10 in bactericidal composition:
1。
In some of embodiments, the total content of Florylpicoxamid and dimethachlon in bactericidal composition be 1~
90wt.%.
In other embodiment, the total content of Florylpicoxamid and dimethachlon in bactericidal composition is 10
~50wt.%.
Preferably, the total content of Florylpicoxamid and dimethachlon in bactericidal composition is 15~45wt.%.
It is highly preferred that the total content of Florylpicoxamid and dimethachlon in bactericidal composition be 18wt.%,
30wt.%, 35wt.% or 44wt.%.
Further, in bactericidal composition of the present invention in addition to effective component, usually also containing common adjuvant on pesticide.
Wherein adjuvant can be wetting agent, dispersing agent, emulsifier, thickener, disintegrating agent, antifreezing agent, defoaming agent, solvent, preservative,
Stabilizer etc. can be properly added according to the needs of preparation.
The wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, nekal, succinic acid
Dibutyl ester sodium sulfonate, Morwet EFW, GY-WS10 etc. are one such or two or more.
The dispersing agent is selected from naphthalene or alkyl naphthalene formaldehyde condensate sulfonate, fatty alcohol ethylene oxide adduct sulfonic acid
Salt, lignin and its derivative sulfonate, APES formaldehyde condensation products sulfat, fatty alcohol polyoxyethylene ether sulphur
Hydrochlorate, acrylate homopolymer sodium salt, Malaysia acid disodium salt etc. are one such or two or more.
The emulsifier is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, castor oil polyoxyethylene ether, alkyl
Phenol polyethenoxy ether, APES formaldehyde condensation product, fatty alcohol polyoxyethylene ether, three phenethyl phenol polyoxyethylene are poly-
Oxypropylene ether, alkylnaphthalene sulfonate, polyoxyethylene carboxylate, AEO series etc. are one such or two or more.
The thickener is selected from white carbon black, kaolin, bentonite, xanthan gum, sodium carboxymethylcellulose etc. therein one
Kind is two or more.
It is one such that the disintegrating agent is selected from urea, bentonite, aluminium chloride, ammonium sulfate, succinic acid, sodium bicarbonate etc.
Or it is two or more.
It is one such or two or more that the antifreezing agent is selected from glycerine, ethylene glycol, propylene glycol etc..
The defoaming agent is selected from organosilicon ketone defoaming agent, C8~10Fatty alcohols defoaming agent etc. it is one such or two
Kind or more.
The solvent is toluene, dimethylbenzene, cyclohexanone, aromatic solvent, methanol, ethyl acetate, soybean oil, epoxy soybean
Oil, castor oil etc. are one such or two or more.
It is one such or two or more that the preservative is selected from sodium benzoate, benzoic acid, potassium sorbate, Kathon CG etc..
The stabilizer is selected from triphenyl phosphite, aceticanhydride, epoxychloropropane, resorcinol, sodium citrate etc. wherein
One or more.
On the other hand, the present invention is provided as prepared by the bactericidal composition comprising Florylpicoxamid and dimethachlon
Preparation, wherein the dosage form of the preparation is missible oil, wettable powder, suspending agent, granule, water dispersible granules, microemulsion, water and milk
Agent, microcapsule formulations.Above-mentioned dosage form can be prepared by the conventional method of this field.
In some of embodiments, in preparation the mass ratio of Florylpicoxamid and dimethachlon be 1~15: 15~
1。
In some of embodiments, in preparation the mass ratio of Florylpicoxamid and dimethachlon be 1~10: 10~
1。
In other embodiment, the mass ratio of Florylpicoxamid and dimethachlon is 1~10: 5~1 in preparation.
Also in some embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 1~10: 1 in preparation.
Also in some embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 1: 10~1 in preparation.
Also in some embodiments, the mass ratio of Florylpicoxamid and dimethachlon is 3~10: 1 in preparation.
Specifically, the mass ratio of Florylpicoxamid and dimethachlon is 1: 1,1: 3,1: 5,1: 10,1: 13,1 in preparation
: 15,3: 1,5: 1,10: 1,13: 1 or 15: 1.
Preferably, the mass ratio of Florylpicoxamid and dimethachlon is 1: 1,3: 1,5: 1 or 10: 1 in preparation.
In some of embodiments, Florylpicoxamid and dimethachlon total quality in preparation account for entire preparation
The 1~90% of quality.
Further, Florylpicoxamid and dimethachlon total quality in preparation account for the entire quality of the pharmaceutical preparations 10~
50%.
Preferably, Florylpicoxamid and dimethachlon total quality in preparation account for the entire quality of the pharmaceutical preparations 15~
45%, toxicity and residues achieve a better balance, and cost is relatively low.
It is highly preferred that Florylpicoxamid and dimethachlon total quality in preparation account for the entire quality of the pharmaceutical preparations 18%,
30%, 35% or 44%.
Preparation of the invention can reach effect same as composition described above, and details are not described herein again.
The present invention provides some preferred preparations to form, specific as follows:
Preferably, the preparation be suspending agent when, the adjuvant include dispersing agent, wetting agent, defoaming agent, thickener,
Stabilizer, antifreezing agent and at least one of the preservatives；Wherein
The dispersing agent preferably includes non-induced by alkyl hydroxybenzene (such as TERSPERSE 4894) and polycarboxylic acid salt (such as GY-
At least one of 900, TERSPERSE 2500), the content in the preparation is preferably 1~5wt.%；
The wetting agent is preferably GY-WS10, and the content in the preparation is preferably 2~5wt.%；
The defoaming agent is preferably organosilicon, and the content in the preparation is preferably 0.1~0.5wt.%；
The thickener is preferably xanthan gum, and the content in the preparation is preferably 0.1~0.5wt.%；
The stabilizer is preferably aluminium-magnesium silicate, and the content in the preparation is preferably 0.3~0.7wt.%；
The antifreezing agent is preferably ethylene glycol, and the content in the preparation is preferably 2~7wt.%；
The preservative is preferably sodium benzoate, and the content in the preparation is preferably 0.05~0.2wt.%.
Preferably, when the preparation is water dispersible granules, the adjuvant includes dispersing agent, filler, thickener, disintegrating agent
At least one of with defoaming agent；Wherein
The dispersing agent preferably includes one of lignin, lignin salt, ethylene oxide propylene oxide block copolymer
Or it is a variety of, the content in the preparation is preferably 4~12wt.%；
The filler preferably includes at least one of organic bentonite and kaolin, and the content in the preparation is preferred
For 20~70wt.%；
The thickener is preferably xanthan gum, and the content in the preparation is preferably 0.1~0.5wt.%；
The disintegrating agent is preferably ammonium sulfate, and the content in the preparation is preferably 5~15wt.%；
The defoaming agent is preferably organosilicon, and the content in the preparation is preferably 0.1~0.5wt.%.
Preferably, when the preparation is wettable powder, the adjuvant includes dispersing agent, disintegrating agent, thickener, defoaming
At least one of agent and filler；Wherein
The dispersing agent preferably includes lignin, lignin salt, in naphthalene sulphonate (such as Morwet D-425)
It is one or more, the content in the preparation is preferably 4~12wt.%；
The disintegrating agent is preferably ammonium sulfate, and the content in the preparation is preferably 5~15wt.%；
The thickener is preferably xanthan gum, and the content in the preparation is preferably 0.1~0.5wt.%；
The defoaming agent is preferably organic silicone (such as DOW CORNING ANTIFOAM C EMULSION), described
Content in preparation is preferably 0.1~0.5wt.%；
The filler preferably includes at least one of organic bentonite and kaolin, and the content in the preparation is preferred
For 20~70wt.%.
Preferably, when the preparation is aqueous emulsion, the adjuvant includes organic solvent, emulsifier, antifreezing agent, thickening
At least one of agent, defoaming agent and water；Wherein
The organic solvent preferably includes at least one of cyclohexanone and dimethylbenzene, and the content in the preparation is preferred
For 5~20wt.%；
The emulsifier is preferably at least one in castor oil polyoxyethylene ether (such as BY-140) or TERMUL 2507
Kind, the content in the preparation is preferably 3~8wt.%；
The antifreezing agent is preferably ethylene glycol, and the content in the preparation is preferably 2~6wt.%；
The thickener is preferably xanthan gum, and the content in the preparation is preferably 0.1~0.5wt.%；
The defoaming agent is preferably organosilicon, and the content in the preparation is preferably 0.1~0.3wt.%.
The above preferred preparation composition, which can improve, improves medicament physicochemical property, such as stability, uniformity, quick-acting or slow
Property released etc., moreover it is possible to improve control efficiency.
Also on the one hand, the present invention provides the bactericidal composition comprising Florylpicoxamid and dimethachlon in prevention and treatment cereal
Application in the powdery mildew of class crop, banded sclerotial blight, rust, sclerotiniose, rice blast and gourd, fruit and vegetable anthracnose.
Further, the present invention provides the bactericidal composition comprising Florylpicoxamid and dimethachlon in prevention and treatment wheat
Application in powdery mildew.
Also on the one hand, the present invention provides the preparation comprising Florylpicoxamid and dimethachlon in prevention and treatment cereal crop
Powdery mildew, banded sclerotial blight, rust, sclerotiniose, the application in rice blast and gourd, fruit and vegetable anthracnose.
Further, the present invention provides the preparation comprising Florylpicoxamid and dimethachlon in prevention and treatment wheat powdery mildew
In application.
In practical application, composition or preparation of the invention can handle all plant and plant part.Plant refers to
All plants and plant population, such as want (whether to be planted with undesired wild plant, cultivar and plant variety
The protection of article kind power or plant breeder's power).Cultivar and plant variety can be (logical by Sterile culture and breeding method
One or more biotechnology methods are crossed to be assisted or supplemented, for example, by using dihaploid, protoplast fusion, at random lure
Become and directed mutagenesis, molecular labeling or genetic marker), or pass through the plant of bioengineering and the acquisition of the method for genetic engineering.It plants
Object part refers to plant all part and organs above and below the ground, wherein list such as bud, leaf, Hua Hegen, such as leaf, needle,
Stem, branch, flower, fructification, fruit and seed and root, bulb and rhizome.Crop and asexual and case of propagation material, such as insert
Item, rhizome, divides bark of a cork tree and seed to also belong to plant part at bulb.
For the present invention, term " effective quantity " refer to be enough to show in dosage desired control efficiency it is each effectively at
The total amount divided.This amount depends on the chemical combination for including in fungi, floristics, weather conditions and the present composition to be controlled
Object and change in a wide range.
Conventional treatment side can be used to the processing that plant and plant part carry out with composition provided by the invention or preparation
Method directly carries out or acts on its ambient enviroment, habitat or storage ground, for example, by dipping, sprinkling, be sprayed, irrigate, evaporate, spread
Powder atomizing, broadcasts sowing, foams, smearing, being coated with, watering (pouring), instiling, and in the case of propagation materials, especially planting
In the case where son, can also by involucrum (incrust), be coated with one or more layers coating etc. with powder-processed dry seeds, with solution
It handles seed, slurries is handled with water-soluble powder.Composition or preparation can be also injected into soil.
In the plant that can be protected by the method for the invention, can be mentioned that staple crops, as corn and soybean, cotton,
Rape, rice, wheat, beet, sugarcane, oat, rye, barley, grain, triticale, flax, liana and come from various plants
The various fruit of taxon and vegetables, gardening and forest crop；Ornamental plant；And the homology of the genetic modification of these crops
Object.
The present invention also includes the method for handling seed.Composition or preparation of the invention can be applied directly, i.e., do not include
Other components and without dilution.Generally, it is preferred to which the present composition is applied to seed with suitable dosage form.Place
The suitable preparation and method for managing seed are that this field is conventional.The present composition can be converted into conventional Seed dressing formulations,
Such as solution, emulsion, suspending agent, pulvis, foaming agent, slurry agent or other be used for seed coating material and ULV preparation.
According to plant species or plant cultivars, their position and growth conditions (soil, weather, trophophase, nutrition),
Processing of the invention can also bring superadditivity (" collaboration ") effect.Thus, for example, the following effect more than actual desired can be brought
Fruit: the rate of application of the composition comprising Ipflufenoquin and jinggangmeisu that can be used according to the invention reduces and/or activity
Spectrum is widened and/or active increases, better plant growth, improve the tolerance to high temperature or low temperature, improve to arid or water or
The tolerance of soil salt content improves Flowering quality, is easier harvesting, hasting of maturity, higher harvesting yield, bigger fruit
Real, higher plant height, greener leaf color, make to bloom earlier, the quality of harvested products is higher and/or nutritive value more
Sugared concentration high, in fruit is higher, harvested products storage stabilities and/or processability are more preferable.
Composition of the invention not only include ready-to-use composition (can be used suitable device be applied to plant or
Seed), and include commercially available concentrate (must be diluted with water before use).
Compared with prior art, bactericidal composition of the invention has the beneficial effect that (1) two kind of effective component compounding, tool
There is good synergistic effect；(2) fungicidal spectrum is expanded, use scope has been widened；(3) delay the generation of drug resistance；(4) life is reduced
Produce cost and use cost；(5) to crop safety.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
It can be obtained by the conventional products of commercially available purchase acquisition or according to prior art preparation.
Indoor biometrics experiment
Mature wheat powdery mildew spore (Erysiphe graminis) is gently shaken off, is inoculated on wheat seeding.Protection
Property test generally handle after for 24 hours left and right be inoculated with；Curative tests 1~4d generally before chemicals treatment is inoculated with；Lasting effect
Test, is administered using different time, inoculation on the day of last time medication；2~3d is inoculated with after soil treatment；The test of blade absorbability
For left and right is inoculated with for 24 hours after processing；Induced activity test etc. is tested with reference to lasting effect.
Wheat seeding greenhouse low humidity culture (15~26 DEG C) after inoculation are classified after 8d according to blank control incidence and investigate.
Grade scale
0 grade: disease-free
1 grade: lesion area accounts for 5% or less full wafer leaf area；
3 grades: lesion area accounts for the 6%~10% of full wafer leaf area；
5 grades: lesion area accounts for the 11%~25% of full wafer leaf area；
7 grades: lesion area accounts for the 26%~50% of full wafer leaf area；
9 grades: lesion area accounts for 50% or more of full wafer leaf area.
Drug effect calculates
Biometrics probability value are tabled look-up according to relative inhibition and can be obtained.Using log concentration as abscissa, according to " biology is united
Count probit value conversion table ", inhibition percentage is converted into biological probability value as ordinate, draws virulence regression equation.It utilizes
The mass concentration that equation acquires when probability value are 5 is EC50(Millot M,Girardot M,Dutreix L,et
al..Antifungal and anti-biofilm activities of acetone lichen extracts against
Candida albicans.[J].Molecules,2017,22(4):651.)。
Coefficient calculation method is spent together using the abundant introduction of Sun Yun, the co-toxicity coefficient (CTC) of mixture is calculated, determines mixture
It is building performance.
(EC is generally selected using single dose a certain in mixture as standard agent50Junior), it is calculated:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Theoretical toxicity index (TTI)=A single dose toxicity index × A single dose proportion+B single dose in mixture virulence
Index × B single dose proportion in mixture
Survey toxicity index (ATI)=standard single dose EC50Value/mixture EC50Value × 100
Co-toxicity coefficient (CTC)=survey toxicity index/theoretical toxicity index × 100
Mixture has synergetic when CTC is greater than 120, is antagonism when CTC is less than 80, and CTC is phase between 80-120
Add effect.
The measurement result of table 1:Florylpicoxamid and dimethachlon different ratio to wheat powdery mildew co-toxicity coefficient
The present invention is using Florylpicoxamid and dimethachlon as effective component, in wider quality than can protect in range
The addition effect held, co-toxicity coefficient 80 or more, when the mass ratio of Florylpicoxamid and dimethachlon is 1~10: 10~
When 1, there is apparent synergistic effect to wheat powdery mildew, it is seen then that the compounding of Florylpicoxamid and dimethachlon can become anti-
Control the favourable agents of wheat powdery mildew.
Preparation example
Preparation example 1
1. crushing the preparation of slurry
Disperse non-induced by alkyl hydroxybenzene dispersant with high efficiency (trade name: TERSPERSE 4894, Huntsman) in water 42.7g
High-molecular compound dispersing agent (trade name: TERSPERSE 2500, Huntsman) 2g, wetting agent (commodity of 2g, comb-type structure
Name: GY-WS10, Beijing Guang Yuan benefit agriculture) 3g and silicone antifoaming agent (Hangzhou Zuo Tu new material Co., Ltd) 0.3g, at it
Middle dispersion Florylpicoxamid raw medicine 25g, dimethachlon 5g are usedBead, with sand mill, (Shenyang is newly micro-
Electrical machinery plant) wet pulverizing 1.5h is carried out, it obtains and crushes slurry 80g.
2. the modulation of decentralized medium
Disperse xanthan gum (Latin reagent) 0.2g, aluminium-magnesium silicate (Aladdin reagent) 0.5g, ethylene glycol in water 15.2g
(Aladdin reagent) 4g and sodium benzoate (Aladdin reagent) 0.1g obtains decentralized medium 20g.
3. the modulation of aqueous suspension shape composition pesticide
Above-mentioned crushing slurry 80g and decentralized medium 20g are mixed, aqueous suspension shape composition pesticide 100g is obtained,
The suspending agent that effective component mass content is 30% is made.
Preparation example 2
By Florylpicoxamid raw medicine 17.5g, dimethachlon 17.5g, EOPO block copolymer (trade name: 848, section's Lay
Grace) 5g, lignin C (Guangzhou Cong Zhongxiao Chemical Co., Ltd.) 3g, ammonium sulfate (Aladdin reagent) 5g, xanthan gum (Aladdin examination
Agent) 0.4g, organobentonite (Hangzhou Zuo Tu new material Co., Ltd) 0.3g, silicone antifoaming agent (the left native green wood in Hangzhou
Material Co., Ltd) 0.2g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) adds to 100g, and first precomminution mixes, then through air-flow
It crushes (the excellent nanogram Machinery Co., Ltd. in Kunshan) to be granulated to required partial size, again using rotating pelletizer, effective component quality is made
The water dispersible granules that content is 35%.
Preparation example 3
By Florylpicoxamid raw medicine 40g, dimethachlon 4g, naphthalene sulphonate (trade name: Morwet D-425,
Akzo Nobel) 5g, lignin C (Hangzhou Zuo Tu new material Co., Ltd) 3g, ammonium sulfate (Aladdin reagent) 5g, xanthan gum
(Aladdin reagent) 0.5g, organic silicone (trade name: DOW CORNING ANTIFOAM C EMULSION, DOW CORNING)
0.2g, kaolin (Hangzhou Zuo Tu new material Co., Ltd) add to 100g, and first precomminution mixes, then (Kunshan is excellent through air-flow crushing
Nanogram Machinery Co., Ltd.) to required partial size, the wettable powder that effective component mass content is 44% is made.
Preparation example 4
1. oily mutually prepare
Florylpicoxamid raw medicine 13.5g, dimethachlon 4.5g are added to cyclohexanone (Aladdin reagent) 7g and diformazan
The in the mixed solvent of benzene (Aladdin reagent) 8g, then by emulsifier (trade name: TERMUL 2507, Huntsman) 3g, castor-oil plant
Oily polyoxyethylene ether (trade name: BY-140, the sincere chemical assistant of Xingtai City swallow) 2g is added and is slowly stirred to being completely dissolved.
2. prepared by water phase
By ethylene glycol (Aladdin reagent) 4g, xanthan gum (Aladdin reagent) 0.1g, silicone antifoaming agent, (Hangzhou is left
Native new material Co., Ltd) 0.2g, water adds 57.7g to stir evenly.
3. composition pesticide aqueous emulsion is deployed
Oil is mutually slowly added in water phase, and be stirred continuously after be added completely into high speed disperser (trade name:
TG25, German IKA) (8000 revs/min) 15 minutes under high shear, the aqueous emulsion that effective component mass content is 18% is made.
Reference examples 1
1. crushing the preparation of slurry
Disperse non-induced by alkyl hydroxybenzene dispersant with high efficiency (trade name: TERSPERSE 4894, Huntsman) in water 42.7g
High-molecular compound dispersing agent (trade name: TERSPERSE 2500, Huntsman) 2g, wetting agent (commodity of 2g, comb-type structure
Name: GY-WS10, Beijing Guang Yuan benefit agriculture) 3g and silicone antifoaming agent (Hangzhou Zuo Tu new material Co., Ltd) 0.3g, at it
Middle dispersion Florylpicoxamid raw medicine 30g is usedBead, with sand mill (the new micro machine factory in Shenyang) into
Row wet pulverizing 1.5h is obtained and is crushed slurry 80g.
2. the modulation of decentralized medium
Disperse xanthan gum (Aladdin reagent) 0.2g, aluminium-magnesium silicate (Aladdin reagent) 0.5g, ethylene glycol in water 15.2g
(Aladdin reagent) 4g and sodium benzoate (Aladdin reagent) 0.1g obtains decentralized medium 20g.
3. the modulation of aqueous suspension shape composition pesticide
Above-mentioned crushing slurry 80g and decentralized medium 20g are mixed, aqueous suspension shape composition pesticide 100g is obtained,
The suspending agent that effective component mass content is 30% is made.
Reference examples 2
Commercially available 40% dimethachlon WP of pesticide is bought in the Jiangxi chemical inc He Yi.
Reference examples 3
Blank clear water.
Field control effectiveness test
Test process: according to the reagent agent experimental design in table 2, three are set separately to the test medicine of preparation example 1-3
A effective ingredient consumption.Comparison medicament is commercially available 40% dimethachlon WP of pesticide and self-control 30%Florylpicoxamid SC respectively
And blank clear water.
Table 2: reagent agent experimental design
Cell setting: each plot area is 66.7m2。
Application method: medicament is administered in wheat powdery mildew early stage, foliar spray processing, and spouting liquid is with drop of not dripping
It is main.
Spraying times: 3 times, strong wind day or it is expected that rainfall in 1 hour, is not administered.State of an illness radix is investigated before application for the first time, with
It was administered afterwards every 7 days 1 time, 7 days investigation preventive effects after the 3rd application.
Control time and number: progress radix investigation in 1 day after application, 5 days after medicine, 10 days, 14 days progress diseases refer to investigation.
Investigation method: according to wheat leaf blade hazard symptoms grading, as unit of strain, 5 points of every cell diagonal line is taken
Sample, every investigation are connected 5 clumps, and totally 25 clumps, record total strain number, diseased plant number and sick series.
Inspection drug effect method after investigating and prevent and treat before application are as follows: 5 points of grab sample in test process area record total leaf
Number, the sick number of sheets, sick series.Grade scale method is as follows:
0 grade: complete stool is disease-free；
1 grade: quaterfoil and its following leaf sheath, blade morbidity (with sword-like leave for first leaf)；
3 grades: third blade and its following leaf sheath, blade morbidity；
5 grades: second blades and its following leaf sheath, blade morbidity；
7 grades: sword-like leave and its following leaf sheath, blade morbidity；
9 grades: complete stool morbidity, it is withered ahead of time.
Drug effect calculates:
Table 3: preventive effect of the different agents to wheat powdery mildew
Comparison medicine is significantly better than to the control efficiency of wheat powdery mildew after both Florylpicoxamid and dimethachlon compounding
Agent, after the two compounds, not only quick-acting is good, but also the lasting period is long, can show synergistic function after showing the two compounding,
Times for spraying can be reduced.In addition, not finding that composition pesticide of the invention has phytotoxicity generation, table to wheat in scope of medication
Bright bactericidal composition of the invention is good to crop safety, can promote and apply.
In conclusion bactericidal composition of the present invention using Florylpicoxamid and dimethachlon as effective component, to small
Wheat powdery mildew and sclerotinia sclerotiorum have good control efficiency, and it is safe to Target crops.Compound preparation not only increases
Preventive effect, and expand fungicidal spectrum, widens use scope, reduces cost, plays the role of that a medicine is simultaneous to be controlled to multiple diseases, mitigates
Manpower and material resources improve productivity effect.So the invention of this compound preparation has a very important significance society with popularization.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. a kind of composition, it is characterised in that: the composition includes Florylpicoxamid and dimethachlon.
2. composition according to claim 1, it is characterised in that: Florylpicoxamid and dimethachlon are in the combination
Mass ratio in object is 1~15: 15~1.
3. composition according to claim 2, it is characterised in that: Florylpicoxamid and dimethachlon are in the combination
Mass ratio in object is 1~10: 10~1.
4. composition according to claim 3, it is characterised in that: Florylpicoxamid and dimethachlon are in the combination
Mass ratio in object is 1~10: 1 or 1: 10~1.
5. composition according to claim 1, it is characterised in that: Florylpicoxamid and dimethachlon are in the combination
Total content in object is 1~90wt.%.
6. composition according to claim 5, it is characterised in that: Florylpicoxamid and dimethachlon are in the combination
Total content in object is 10~50wt.%.
7. composition according to claim 6, it is characterised in that: Florylpicoxamid and dimethachlon are in the combination
Total content in object is 15~45wt.%.
8. composition described in claim 1-7 any one is in powdery mildew, banded sclerotial blight, the rust, bacterium of prevention and treatment cereal crop
Application in core disease, rice blast and gourd, fruit and vegetable anthracnose.
9. preparation prepared by composition described in claim 1-7 any one, it is characterised in that: the dosage form of the preparation is
Missible oil, wettable powder, suspending agent, granule, water dispersible granules, microemulsion, aqueous emulsion or microcapsule formulations.
10. preparation as claimed in claim 9 is in powdery mildew, banded sclerotial blight, rust, the sclerotiniose, rice blast of prevention and treatment cereal crop
And the application in gourd, fruit and vegetable anthracnose.
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| CN114304160A (en) * | 2020-09-30 | 2022-04-12 | 江苏龙灯化学有限公司 | Synergistic bactericidal composition |
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| CN114304160A (en) * | 2020-09-30 | 2022-04-12 | 江苏龙灯化学有限公司 | Synergistic bactericidal composition |
| CN114304160B (en) * | 2020-09-30 | 2024-02-23 | 江苏龙灯化学有限公司 | Synergistic bactericidal composition |
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